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Aliases & Descriptions for WDR33
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases FLJ11294 1 , 2 WDC146 1 , 2 , 3
Descriptions WD repeat domain 33 2 WD repeat-containing protein WDC146 3
Search outside databases for aliases for WDR33 genePrevious GC identifer: GC02M128557
Summaries for WDR33 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for WDR33 : This gene encodes a member of the WD repeat protein family. WD repeats are minimally conservedregions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), whichmay facilitate formation of heterotrimeric or multiprotein complexes. Members of this family areinvolved in a variety of cellular processes, including cell cycle progression, signaltransduction, apoptosis, and gene regulation. This gene is highly expressed in testis and theprotein is localized to the nucleus. This gene may play important roles in the mechanisms ofcytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variantsencoding distinct isoforms have been found for this gene. [provided by RefSeq] Gene Wiki entry for WDR33
Genomic Location for WDR33
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the WDR33 gene Entrez Gene cytogenetic band: 2q14.3 Ensembl cytogenetic band: 2q14.3 HGNC cytogenetic band: 2q21.1 WDR33 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M128179:
(about GC identifiers )
Start:
128,178,278 bp from pter
End:
128,285,215 bp from pter
Size:
106,938 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000002.10 NT_022135.15 Proteins for WDR33
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: WDR33_HUMAN, Q9C0J8 (See
protein sequence )Recommended Name: WD repeat-containing protein 33 Size : 1336 amino acids; 145891 Da
Subcellular location : Nucleus
Secondary accessions : Q587J1
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_001006623.1 NP_001006624.1 NP_060853.3 ENSEMBL proteins: ENSP00000325377 ENSP00000376730 ENSP00000387186 ENSP00000386861 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
About this table Antibodies for WDR33: Assays for WDR33:
Protein
Domains/ Families for WDR33(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9C0J8 ProtoNet protein and cluster: Q9C0J8
1 Blocks protein family : IPB008160 Collagen triple helix repeat UniProtKB/Swiss-Prot: WDR33_HUMAN, Q9C0J8 Similarity : Contains 1 collagen-like domainSimilarity : Contains 7 WD repeats
Gene Function for WDR33
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_001006622 Applied Biosystems Silencer ® siRNAs for WDR33 Sigma-Aldrich siRNA and siRNA Panels for WDR33 Sigma-Aldrich shRNA for WDR33 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001006622                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001006622                                  untagged cDNA clones in CMV expression vector (see all 4 ): BC013990  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018383 2 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for WDR33
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Interacting protein for WDR33 (Q9C0J8 1 ) via UniProtKB, MINT, and/or STRING About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
About this table
Drugs & Compounds for WDR33 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for WDR33
Transcripts for WDR33(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
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shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_001006622 Sigma-Aldrich siRNA and siRNA Panels for WDR33 Sigma-Aldrich shRNA for WDR33 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001006622 NM_001006623 NM_018383
REFSEQ mRNAs for WDR33 gene (3 alternative transcripts): NM_001006622.1 NM_001006623.1 NM_018383.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001006622 NM_001006623 NM_018383
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001006622                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001006622                                  untagged cDNA clones in CMV expression vector (see all 4 ): BC013990  
Additional cDNA sequence: AB044749.1 AK002156.1 AK098003.1 AK123510.1 AK223319.1 AL834365.1 BC005401.1 BC010283.1 BC013990.2 BC068484.1 BC108671.1 CR591938.1
20 DOTS entries : DT.85105571 DT.101981406 DT.210433 DT.99988925 DT.410657 DT.95193952 DT.114076 DT.95277296 DT.425610 DT.100777349 DT.216281 DT.100751287 DT.100777350 DT.40121162 DT.92436263 DT.95287644 DT.120966393 DT.120966449 DT.121488446 DT.91988481
24/298 AceView cDNA sequences (see all 298
):AA773744 CK820474 BC068484 BX103711 AI039494 BG283913 BE859089 BM751741 BQ277834 AA491257 BQ896760 BF063402 CA395595 Z41772 BX115033 F10034 AA284061 BF931513 BM928629 BQ011321 AA927896 BM718079 BU538276 AA339047
highest scoring ESTs for WDR33 :AA827926 AI480300 N48582 AA460084 AA630806 AB044749 AK002156 AL561047 AU138991 BC005401
Unigene Cluster for WDR33: WD repeat domain 33 Hs.620490 [show with all ESTs ] Unigene Representative Sequence: NM_018383 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for WDR33 (see all 8
) ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ SP1 :       -   -               -     -   -   -           -             SP2 :       -   -               -     -   -                         SP3 :                                                     SP4 :       -   -                                             SP5 :       -                                              
ExUns: 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 SP1 :                     SP2 :                     SP3 :       -   -             SP4 :                     SP5 :                    
About this scheme ECgene alternative splicing isoforms for WDR33 4 Ensembl transcripts including schematic representations : ENST00000322313
ENST00000393006
ENST00000409658
ENST00000408998
Expression for WDR33
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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WDR33 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for WDR33 1 / 2 / 3
16 probe-sets matching WDR33 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GGCTCTGTCASOURCE GeneReport for Unigene cluster: Hs.620490 UniProtKB/Swiss-Prot: WDR33_HUMAN, Q9C0J8 Tissue specificity : Most highly expressed in testis
Orthologs for WDR33
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for WDR33 gene from 5/19 species (see all 19
)
About this table Species with no ortholog for WDR33 ENSEMBL Gene Tree for WDR33 Paralogs for WDR33 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for WDR33 gene PRB4 2 PRB3 2
SNPs/Variants for WDR33 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for WDR33 (up to first 250kb)
Disorders & Mutations for WDR33
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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--
Medical News for WDR33 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for WDR33 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/12 PubMed articles for WDR33 gene (see all 12
):
Search for WDR33
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing WDR33
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing WDR33
(According to HUGE )
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Specialized Databases showing WDR33 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for WDR33 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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