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Aliases for WDR33 Gene

Aliases for WDR33 Gene

  • WD Repeat Domain 33 2 3 5
  • WD Repeat-Containing Protein WDC146 3 4
  • WD Repeat-Containing Protein 33 3 4
  • WDC146 3 4
  • Pre-MRNA 3 End Processing Protein WDR33 3
  • NET14 3

External Ids for WDR33 Gene

Previous GeneCards Identifiers for WDR33 Gene

  • GC02M128557
  • GC02M128179
  • GC02M120768
  • GC02M128458

Summaries for WDR33 Gene

Entrez Gene Summary for WDR33 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR33 Gene

WDR33 (WD Repeat Domain 33) is a Protein Coding gene. Among its related pathways are Gene Expression and Transport of the SLBP independent Mature mRNA. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for WDR33 Gene

  • Essential for both cleavage and polyadenylation of pre-mRNA 3 ends.

Gene Wiki entry for WDR33 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR33 Gene

Genomics for WDR33 Gene

Regulatory Elements for WDR33 Gene

Enhancers for WDR33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G127099 1.6 Ensembl ENCODE dbSUPER 16.8 +706.9 706947 8.6 FOXA2 PKNOX1 CREB3L1 MLX AGO1 ZFP64 ARID4B SIN3A DMAP1 FEZF1 AMMECR1L WDR33 BIN1 ERCC3 ENSG00000260634
GH02G128321 1.5 Ensembl ENCODE dbSUPER 15.6 -511.1 -511103 2.2 ATF1 ARID4B SIN3A DMAP1 ZNF48 GTF3C2 ZNF143 ZNF207 KLF13 SP3 AMMECR1L WDR33 UGGT1 HS6ST1 GC02M128305
GH02G127051 1.1 dbSUPER 16.8 +757.8 757835 3.4 HDGF FOXA2 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 BIN1 AMMECR1L WDR33 ERCC3 ENSG00000260634 GPR17 LOC105373604
GH02G127052 1.1 dbSUPER 16.8 +758.2 758197 1.0 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 BIN1 AMMECR1L WDR33 ERCC3 ENSG00000260634
GH02G127057 1.1 dbSUPER 16.8 +757.6 757646 4.3 HDGF FOXA2 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 BIN1 AMMECR1L WDR33 ERCC3 ENSG00000260634 LOC105373604 GPR17
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR33 on UCSC Golden Path with GeneCards custom track

Promoters for WDR33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000122922 387 2401 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for WDR33 Gene

Chromosome:
2
Start:
127,701,022 bp from pter
End:
127,811,187 bp from pter
Size:
110,166 bases
Orientation:
Minus strand

Genomic View for WDR33 Gene

Genes around WDR33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR33 Gene

Proteins for WDR33 Gene

  • Protein details for WDR33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0J8-WDR33_HUMAN
    Recommended name:
    pre-mRNA 3 end processing protein WDR33
    Protein Accession:
    Q9C0J8
    Secondary Accessions:
    • Q05DP8
    • Q53FG9
    • Q587J1
    • Q69YF7
    • Q6NUQ0
    • Q9NUL1

    Protein attributes for WDR33 Gene

    Size:
    1336 amino acids
    Molecular mass:
    145891 Da
    Quaternary structure:
    • Component of the cleavage and polyadenylation specificity factor (CPSF) module of the pre-mRNA 3-end processing complex. Interacts with CPSF3/CPSF73.

    Alternative splice isoforms for WDR33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR33 Gene

Post-translational modifications for WDR33 Gene

  • Ubiquitination at Lys28, Lys55, Lys65, Lys109, Lys119, and posLast=216216
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for WDR33
  • Santa Cruz Biotechnology (SCBT) Antibodies for WDR33

No data available for DME Specific Peptides for WDR33 Gene

Domains & Families for WDR33 Gene

Gene Families for WDR33 Gene

Suggested Antigen Peptide Sequences for WDR33 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR33: view

No data available for UniProtKB/Swiss-Prot for WDR33 Gene

Function for WDR33 Gene

Molecular function for WDR33 Gene

UniProtKB/Swiss-Prot Function:
Essential for both cleavage and polyadenylation of pre-mRNA 3 ends.

Gene Ontology (GO) - Molecular Function for WDR33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
genes like me logo Genes that share ontologies with WDR33: view
genes like me logo Genes that share phenotypes with WDR33: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR33 Gene

Localization for WDR33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR33 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR33 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for WDR33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005581 collagen trimer IEA --
GO:0005634 nucleus IDA,IEA 11162572
GO:0005654 nucleoplasm TAS --
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IBA --
genes like me logo Genes that share ontologies with WDR33: view

Pathways & Interactions for WDR33 Gene

genes like me logo Genes that share pathways with WDR33: view

Pathways by source for WDR33 Gene

Gene Ontology (GO) - Biological Process for WDR33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006301 postreplication repair NAS 11162572
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006379 mRNA cleavage IBA --
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with WDR33: view

No data available for SIGNOR curated interactions for WDR33 Gene

Transcripts for WDR33 Gene

Unigene Clusters for WDR33 Gene

WD repeat domain 33:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR33 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - - -
SP2: - - - - -
SP3:
SP4: - -
SP5: -
SP6: -
SP7:
SP8:

ExUns: 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27
SP1:
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for WDR33 Gene

GeneLoc Exon Structure for
WDR33
ECgene alternative splicing isoforms for
WDR33

Expression for WDR33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR33 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (20.6), Peripheral blood mononuclear cells (14.3), and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR33 Gene



Protein tissue co-expression partners for WDR33 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR33 Gene:

WDR33

SOURCE GeneReport for Unigene cluster for WDR33 Gene:

Hs.554831

mRNA Expression by UniProt/SwissProt for WDR33 Gene:

Q9C0J8-WDR33_HUMAN
Tissue specificity: Most highly expressed in testis.

Evidence on tissue expression from TISSUES for WDR33 Gene

  • Nervous system(4.8)
  • Intestine(4.3)
  • Liver(4.2)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with WDR33: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR33 Gene

Orthologs for WDR33 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR33 34 35
  • 99.83 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR33 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR33 34 35
  • 94.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR33 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR33 34 35
  • 93.74 (n)
rat
(Rattus norvegicus)
Mammalia Wdr33 34
  • 90.41 (n)
mouse
(Mus musculus)
Mammalia Wdr33 16 35 34
  • 90.26 (n)
chicken
(Gallus gallus)
Aves WDR33 34 35
  • 80.77 (n)
lizard
(Anolis carolinensis)
Reptilia WDR33 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1975 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15112 34
zebrafish
(Danio rerio)
Actinopterygii wdr33 34 35
  • 74.93 (n)
Dr.12330 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6030 34
fruit fly
(Drosophila melanogaster)
Insecta CG1109 35
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pfs-2 35
  • 43 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E07085g 34
  • 53.26 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PFS2 34 35 37
  • 49.95 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL184W 34
  • 49.86 (n)
rice
(Oryza sativa)
Liliopsida Os.16005 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 61 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pfs2 34
  • 54.54 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00037 34
  • 52.47 (n)
Species where no ortholog for WDR33 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR33 Gene

ENSEMBL:
Gene Tree for WDR33 (if available)
TreeFam:
Gene Tree for WDR33 (if available)

Paralogs for WDR33 Gene

(3) SIMAP similar genes for WDR33 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WDR33: view

No data available for Paralogs for WDR33 Gene

Variants for WDR33 Gene

Sequence variations from dbSNP and Humsavar for WDR33 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000000667 -- 127,783,696(+) GCCTC(C/T)TAGGT intron-variant
rs1000050018 -- 127,793,443(+) AAAAA(A/C)AAAAA intron-variant
rs1000079653 -- 127,778,162(+) TGGGT(G/T)CAGTG intron-variant
rs1000109771 -- 127,734,883(+) TAACC(A/T)CACTT intron-variant, downstream-variant-500B
rs1000200698 -- 127,785,073(+) AGGTT(A/G)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR33 Gene

Variant ID Type Subtype PubMed ID
dgv4069n100 CNV gain 25217958
esv26495 CNV loss 19812545
esv2659176 CNV deletion 23128226
esv2672967 CNV deletion 23128226
esv3560103 CNV deletion 23714750
esv3592367 CNV loss 21293372
esv3592368 CNV loss 21293372
nsv470482 CNV loss 18288195
nsv471921 CNV novel sequence insertion 20440878
nsv583038 CNV loss 21841781

Variation tolerance for WDR33 Gene

Residual Variation Intolerance Score: 1.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.87; 67.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR33 Gene

Disorders for WDR33 Gene

Relevant External Links for WDR33

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR33

No disorders were found for WDR33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR33 Gene

Publications for WDR33 Gene

  1. Molecular architecture of the human pre-mRNA 3' processing complex. (PMID: 19217410) Shi Y. … Manley J.L. (Mol. Cell 2009) 2 3 4 64
  2. A novel WD40 repeat protein, WDC146, highly expressed during spermatogenesis in a stage-specific manner. (PMID: 11162572) Ito S. … Shimizu K. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64

Products for WDR33 Gene

Sources for WDR33 Gene

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