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Aliases for WDR33 Gene

Aliases for WDR33 Gene

  • WD Repeat Domain 33 2 3 5
  • WD Repeat-Containing Protein WDC146 3 4
  • WD Repeat-Containing Protein 33 3 4
  • WDC146 3 4
  • NET14 3

External Ids for WDR33 Gene

Previous GeneCards Identifiers for WDR33 Gene

  • GC02M128557
  • GC02M128179
  • GC02M120768
  • GC02M128458

Summaries for WDR33 Gene

Entrez Gene Summary for WDR33 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR33 Gene

WDR33 (WD Repeat Domain 33) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for WDR33 Gene

  • Essential for both cleavage and polyadenylation of pre-mRNA 3 ends.

Gene Wiki entry for WDR33 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR33 Gene

Genomics for WDR33 Gene

Regulatory Elements for WDR33 Gene

Enhancers for WDR33 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR33 on UCSC Golden Path with GeneCards custom track

Promoters for WDR33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR33 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR33 Gene

127,701,022 bp from pter
127,811,187 bp from pter
110,166 bases
Minus strand

Genomic View for WDR33 Gene

Genes around WDR33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR33 Gene

Proteins for WDR33 Gene

  • Protein details for WDR33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    pre-mRNA 3 end processing protein WDR33
    Protein Accession:
    Secondary Accessions:
    • Q05DP8
    • Q53FG9
    • Q587J1
    • Q69YF7
    • Q6NUQ0
    • Q9NUL1

    Protein attributes for WDR33 Gene

    1336 amino acids
    Molecular mass:
    145891 Da
    Quaternary structure:
    • Component of the cleavage and polyadenylation specificity factor (CPSF) module of the pre-mRNA 3-end processing complex. Interacts with CPSF3/CPSF73.

    Alternative splice isoforms for WDR33 Gene


neXtProt entry for WDR33 Gene

Proteomics data for WDR33 Gene at MOPED

Post-translational modifications for WDR33 Gene

  • Ubiquitination at Lys 28, Lys 55, Lys 65, Lys 109, Lys 119, and Lys 216
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR33 Gene

Antibody Products

  • Abcam antibodies for WDR33

No data available for DME Specific Peptides for WDR33 Gene

Domains & Families for WDR33 Gene

Gene Families for WDR33 Gene

Protein Domains for WDR33 Gene

Suggested Antigen Peptide Sequences for WDR33 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 collagen-like domain.
  • Contains 7 WD repeats.
  • Contains 1 collagen-like domain.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR33: view

Function for WDR33 Gene

Molecular function for WDR33 Gene

UniProtKB/Swiss-Prot Function:
Essential for both cleavage and polyadenylation of pre-mRNA 3 ends.
genes like me logo Genes that share phenotypes with WDR33: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR33 Gene

Localization for WDR33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR33 Gene

Subcellular locations from

Jensen Localization Image for WDR33 Gene COMPARTMENTS Subcellular localization image for WDR33 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for WDR33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IBA --
genes like me logo Genes that share ontologies with WDR33: view

Pathways & Interactions for WDR33 Gene

SuperPathways for WDR33 Gene

Superpath Contained pathways
1 mRNA surveillance pathway
genes like me logo Genes that share pathways with WDR33: view

Pathways by source for WDR33 Gene

1 KEGG pathway for WDR33 Gene

Gene Ontology (GO) - Biological Process for WDR33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006378 mRNA polyadenylation IBA --
GO:0006379 mRNA cleavage IBA --
genes like me logo Genes that share ontologies with WDR33: view

No data available for SIGNOR curated interactions for WDR33 Gene

Drugs & Compounds for WDR33 Gene

No Compound Related Data Available

Transcripts for WDR33 Gene

Unigene Clusters for WDR33 Gene

WD repeat domain 33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR33 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - - -
SP2: - - - - -
SP4: - -
SP5: -
SP6: -

ExUns: 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27
SP3: - -

Relevant External Links for WDR33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR33 Gene

mRNA expression in normal human tissues for WDR33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR33 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (20.6), Peripheral blood mononuclear cells (14.3), and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR33 Gene

SOURCE GeneReport for Unigene cluster for WDR33 Gene Hs.554831

mRNA Expression by UniProt/SwissProt for WDR33 Gene

Tissue specificity: Most highly expressed in testis.
genes like me logo Genes that share expression patterns with WDR33: view

Protein tissue co-expression partners for WDR33 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for WDR33 Gene

Orthologs for WDR33 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR33 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR33 35
  • 93.74 (n)
  • 98.13 (a)
WDR33 36
  • 98 (a)
(Canis familiaris)
Mammalia WDR33 35
  • 94.24 (n)
  • 98.43 (a)
WDR33 36
  • 98 (a)
(Mus musculus)
Mammalia Wdr33 35
  • 90.26 (n)
  • 96.43 (a)
Wdr33 16
Wdr33 36
  • 96 (a)
(Pan troglodytes)
Mammalia WDR33 35
  • 99.83 (n)
  • 99.93 (a)
WDR33 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Wdr33 35
  • 90.41 (n)
  • 96.97 (a)
(Monodelphis domestica)
Mammalia WDR33 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia WDR33 36
  • 94 (a)
(Gallus gallus)
Aves WDR33 35
  • 80.77 (n)
  • 89.64 (a)
WDR33 36
  • 90 (a)
(Anolis carolinensis)
Reptilia WDR33 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1975 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15112 35
(Danio rerio)
Actinopterygii Dr.12330 35
wdr33 35
  • 74.93 (n)
  • 87.6 (a)
wdr33 36
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6030 35
fruit fly
(Drosophila melanogaster)
Insecta CG1109 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea pfs-2 36
  • 43 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL184W 35
  • 49.86 (n)
  • 44.23 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E07085g 35
  • 53.26 (n)
  • 45.4 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PFS2 35
  • 49.95 (n)
  • 41.6 (a)
PFS2 36
  • 37 (a)
PFS2 38
(Oryza sativa)
Liliopsida Os.16005 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00037 35
  • 52.47 (n)
  • 47.71 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pfs2 35
  • 54.54 (n)
  • 48.25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
Species with no ortholog for WDR33:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR33 Gene

Gene Tree for WDR33 (if available)
Gene Tree for WDR33 (if available)

Paralogs for WDR33 Gene

(3) SIMAP similar genes for WDR33 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WDR33: view

No data available for Paralogs for WDR33 Gene

Variants for WDR33 Gene

Sequence variations from dbSNP and Humsavar for WDR33 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs11557686 - 127,770,885(+) TTGTG(A/C)AAAAT reference, missense
rs12615078 - 127,719,893(+) GGCCA(C/G)GTGGA reference, missense
rs705048 -- 127,793,796(+) CACCA(C/T)CTTAC intron-variant
rs705049 -- 127,802,374(+) tctcc(C/T)gggtg intron-variant
rs705093 -- 127,746,960(+) TCAAT(C/T)CTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR33 Gene

Variant ID Type Subtype PubMed ID
nsv875015 CNV Loss 21882294
dgv4299n71 CNV Loss 21882294
nsv470482 CNV Loss 18288195
dgv4301n71 CNV Loss 21882294
nsv875030 CNV Loss 21882294
nsv875033 CNV Loss 21882294
esv2672967 CNV Deletion 23128226
esv26495 CNV Loss 19812545
esv2659176 CNV Deletion 23128226

Variation tolerance for WDR33 Gene

Residual Variation Intolerance Score: 1.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.87; 67.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WDR33 Gene

Disorders for WDR33 Gene

Relevant External Links for WDR33

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WDR33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR33 Gene

Publications for WDR33 Gene

  1. A novel WD40 repeat protein, WDC146, highly expressed during spermatogenesis in a stage-specific manner. (PMID: 11162572) Ito S. … Shimizu K. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for WDR33 Gene

Sources for WDR33 Gene