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WDR32 Gene

protein-coding GIFtS: 44

GC09P037792

WD repeat domain 32
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ23201 ^¹, ²
MGC10765 ^¹, ²
MGC131781 ^²
OTTHUMP00000046127 ^²

Descriptions
WD repeat domain 32 ^²

External Ids
HGNC: 23686¹
Entrez Gene: 79269²
UniProtKB: Q5QP82³
Ensembl: ENSG00000122741⁷

Search outside databases for aliases for WDR32 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the WDR32 gene

Entrez Gene cytogenetic band: 9p13.2 Ensembl cytogenetic band: 9p13.2 HGNC cytogenetic band: 9p13.2

WDR32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P037792: (about GC identifiers)

Start:	37,790,790 bp from pter
End:	37,857,666 bp from pter
Size:	66,877 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_008413.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WDR32_HUMAN, Q5QP82 (See protein sequence)

Recommended Name: WD repeat-containing protein 32

Size: 559 amino acids; 60582 Da

Secondary accessions: A4VCJ5 Q32NE2 Q8N2Q5 Q96ET5 Q9BTQ5 Q9H5P6

Alternative splicing: 2 isoforms: Q5QP82-1 Q5QP82-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_077321.3

ENSEMBL proteins:

ENSP00000242323 ENSP00000259537 ENSP00000366953

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (WDR32)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for WDR32:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for WDR32
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Monoclonal and Polyclonal Antibodies from Abnova (WDR32)
	Novus Biologicals Antibody for WDR32

Assays for WDR32:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q5QP82

ProtoNet protein and cluster: Q5QP82

UniProtKB/Swiss-Prot: WDR32_HUMAN, Q5QP82

Similarity: Belongs to the WD repeat WDR32 family

Similarity: Contains 7 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR32)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (WDR32)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024345

Applied Biosystems Silencer® siRNAs for WDR32

Sigma-Aldrich siRNA for WDR32

Sigma-Aldrich shRNA for WDR32

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_024345
Myc/DDK tagged cDNA clone in CMV expression vector: NM_024345
untagged cDNA clones in CMV expression vector (see all 3): BD127152

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_024345

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR32

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR32)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (WDR32)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024345

Sigma-Aldrich siRNA for WDR32

Sigma-Aldrich shRNA for WDR32

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_024345

REFSEQ mRNAs for WDR32 gene:

NM_024345.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_024345

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024345
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024345
                                 untagged cDNA clones in CMV expression vector (see all 3): BD127152

Additional cDNA sequence:

AK023620.1 AK026854.1 AK074532.1 AK309712.1 AK315756.1 BC003520.1 BC011959.1 BC108686.1

BC139834.1

24/27 DOTS entries (see all 27 ):

DT.97770540 DT.97840892 DT.100754517 DT.91724311 DT.121192742 DT.445659 DT.102832930 DT.95341413

DT.121192550 DT.452246 DT.100891183 DT.121643351 DT.121192827 DT.121192549 DT.409006 DT.100754519

DT.121192528 DT.121192653 DT.95168046 DT.121192770 DT.121631911 DT.100754514 DT.121192571 DT.121192787

24/112 AceView cDNA sequences (see all 112 ):

BC011959 BU684386 AI028736 AI368140 Z44041 NM_024345 AA648750 AI338426

BM842485 AK074532 BC003520 CD299973 AI250686 BU194027 BX430914 AA302573

AA468836 AI085446 AA938632 BM423996 BE393283 CA412666 BM472469 AW268422

highest scoring ESTs for WDR32:

AL110429 AA085503 AA196458 AA468836 AA491687 AA648750 AA938632 AI016757 AI028736 AI085446

Unigene Cluster for WDR32:

WD repeat domain 32

Hs.118394 [show with all ESTs]

Unigene Representative Sequence: NM_024345

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for WDR32 (see all 8 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	·	7e	^	8	^	9a	·	9b	·	9c	·	9d
SP1:																					-						-		-		-
SP2:																	-				-
SP3:											-										-
SP4:																	-		-		-
SP5:			-

About this scheme

ECgene alternative splicing isoforms for WDR32

3 Ensembl transcripts including schematic representations:

ENST00000242323 ENST00000352264 ENST00000377724

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR32 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for WDR32

¹ / ² / ³

12 probe-sets matching WDR32 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
60965_at²^{, 3}	U95-C	1	1.00	1.00	0.51	0.71	AA196443	0.40	1.00	0.76	1
58488_at²^{, 3}	U95-C	1	1.00	1.00	-0.10	1.07	AA040130	0.40	1.00	0.76	1
87951_at²^{, 3}	U95-E	1	1.00	1.00	0.59	0.82	AL120694	0.40	1.00	0.76	1
55621_at²^{, 3}	U95-B	1	0.94	1.00	0.36	1.44	AL110429	1.00	1.00	1.00	1
230679_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA976778	0.20	1.00	0.72	1
226511_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AU157441	0.20	1.00	0.72	1
219001_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_024345	0.60	1.00	0.82	1
222804_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	N58163	0.80	1.00	0.91	1
230679_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226511_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
219001_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222804_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks WDR32 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGAAACGCC

SOURCE GeneReport for Unigene cluster: Hs.118394

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WDR32 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WDR32¹	--	WD repeat domain 32	92.67(n) 92.84(a)	481617 XM_538739.2 XP_538739.2
chimpanzee (Pan troglodytes)	WDR32¹	--	WD repeat domain 32	99.82(n) 99.82(a)	747608 XM_001170070.1 XP_001170070.1
cow (Bos taurus)	WDR32¹	--	WD repeat domain 32	89.55(n) 89.61(a)	509776 XM_586808.3 XP_586808.3
rat (Rattus norvegicus)	Wdr32¹	--	WD repeat domain 32	89.35(n) 89.59(a)	313242 XM_232999.4 XP_232999.2
mouse (Mus musculus)	Wdr32^{1, 5}	4⁵	WD repeat domain 32^{1, 5}	88.75(n)¹ 89.77(a)¹	242418¹ NM_153167.2¹ NP_694807.2¹ AA386744⁵ AA415554⁵ (see all 26)

About this table Species with no ortholog for WDR32

ENSEMBL Gene Tree for WDR32

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/410 NCBI SNPs in WDR32 are shown (see all 410 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 96)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7859075^1,2	A,C,F,H	37855943(+)	`ACTCTA/GAGAAT`	1	--	ut3¹		4		EU EA WA	418
	rs10115457^1,2	A,C,F,H	37851794(+)	`TGTCAC/AGTTCC`	1	--	ut3¹ ese³		7		NA EU EA WA	562
	rs7049213^1,2	A,C,F,H	37789031(+)	`TCACCG/CTCTAT`	1	--	ng5¹		8		EU EA WA	834
	rs7049161^1,2	A,C,F,H	37789238(+)	`GCCTCA/CTGGAC`	1	--	ng5¹		4		EU EA WA	418
	rs7025756^1,2	C,F,H	37857989(+)	`ctggcT/Ctaaag`	1	--	ng3¹		4		EU EA WA	420
	rs10511954^1,2	C,F,H	37856551(-)	`CATTAG/AAAGAA`	1	--	ut3¹		12		NS NA EU EA WA	660
	rs3180508^1,2	C,F,H	37853622(+)	`ATGGAC/AACTTT`	1	--	ut3¹		7		NA EU EA WA	562
	rs1998586^1,2	C,F,H	37789265(-)	`AGTAAC/ACAGGC`	1	--	ng5¹		8		EU EA WA	820
--	rs10814624^1,2	A,C	37790692(+)	`CCCAAA/GCCCGG`	1	--	ng5¹		0	--	--	--	--
--	rs11556059^1,2	C,F	37857191(-)	`TCCTTA/GGGGCT`	1	--	ut3¹		3		NA	142

About this table

HapMap Linkage Disequilibrium images for WDR32 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for WDR32 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)⁴ Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 79269	HGNC: 23686	AceView: MGC10765	Ensembl:ENSG00000122741	euGenes: HUgn79269
ECgene: WDR32	H-InvDB: WDR32

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for WDR32
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for WDR32:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for WDR32-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for WDR32		Antibodies for WDR32
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for WDR32		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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WDR32 Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for WDR32

Summaries
for WDR32

Genomic Location
for WDR32

Proteins
for WDR32

Protein Domains/
Families
for WDR32

Gene Function
for WDR32

Pathways & Interactions
for WDR32

Drugs & Compounds
for WDR32

Transcripts
for WDR32

Expression
for WDR32

Orthologs
for WDR32

Paralogs
for WDR32

SNPs/Variants
for WDR32

Disorders & Mutations
for WDR32

Medical News
for WDR32

Publications
for WDR32

Search for WDR32

Genome Databases showing WDR32

Other Databases showing WDR32

Specialized Databases showing WDR32

Licensable Technologies
for WDR32

Services
for WDR32

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WDR32 Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor WDR32

Summariesfor WDR32

Genomic Locationfor WDR32

Proteinsfor WDR32

Protein Domains/Familiesfor WDR32

Gene Functionfor WDR32

Pathways & Interactionsfor WDR32

Drugs & Compoundsfor WDR32

Transcriptsfor WDR32

Expression for WDR32

Orthologsfor WDR32

Paralogsfor WDR32

SNPs/Variantsfor WDR32

Disorders & Mutationsfor WDR32

Medical Newsfor WDR32

Publicationsfor WDR32

Search for WDR32

Genome Databases showing WDR32

Other Databases showing WDR32

Specialized Databases showing WDR32

Licensable Technologiesfor WDR32

Servicesfor WDR32

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for WDR32

Summaries
for WDR32

Genomic Location
for WDR32

Proteins
for WDR32

Protein Domains/
Families
for WDR32

Gene Function
for WDR32

Pathways & Interactions
for WDR32

Drugs & Compounds
for WDR32

Transcripts
for WDR32

Expression
for WDR32

Orthologs
for WDR32

Paralogs
for WDR32

SNPs/Variants
for WDR32

Disorders & Mutations
for WDR32

Medical News
for WDR32

Publications
for WDR32

Licensable Technologies
for WDR32

Services
for WDR32