WDR31 Gene
protein-coding GIFtS: 43
GCID: GC09M116077
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|
WD repeat domain 31
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Aliases
for WDR31 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 311 2 | | FLJ359211 | | WD Repeat-Containing Protein 312 |
Export aliases for WDR31 gene to outside databasesPrevious GC identifers: GC09M111451 GC09M113155 GC09M115115 GC09M085685 |
Summaries
for WDR31 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WDR31:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric ormultiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycleprogression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variantsencoding distinct isoforms have been found for this gene but the biological validity of some variants has not beendetermined. (provided by RefSeq, Jul 2008)
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Genomic Views
for WDR31 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR31 gene promoter:
c-Fos AP-1 NF-kappaB Max NF-kappaB2 HFH-1 FOXO1a c-Jun NF-kappaB1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR31
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR31 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q32 Ensembl cytogenetic band: 9q32 HGNC cytogenetic band: 9q33.1WDR31 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M116077: view genomic region
(about GC identifiers)
Start:
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116,077,930 bp from pter |
End:
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116,102,620 bp from pter |
Size:
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24,691 bases |
Orientation:
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minus strand |
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Proteins
for WDR31 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR31_HUMAN, Q8NA23 (See
protein sequence)Recommended Name: WD repeat-containing protein 31 Size: 367 amino acids; 40840 Da
Secondary accessions: Q5W0T9 Q96EG8Alternative splicing: 2 isoforms: Q8NA23-1 Q8NA23-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for WDR31: NX_Q8NA23
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NA23
WDR31 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001012361.1 NP_660284.1
ENSEMBL proteins: ENSP00000363308 ENSP00000420074 ENSP00000345027 ENSP00000419246 ENSP00000363310
Human Recombinant Protein Products:
WDR31 Antibody Products:
Assay Products for WDR31: |
Protein
Domains /
Families
for WDR31 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR31 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NA23ProtoNet protein and cluster: Q8NA23 UniProtKB/Swiss-Prot: WDR31_HUMAN, Q8NA23Similarity: Contains 5 WD repeats |
Function
for WDR31 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR31 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR31 (see all 3)
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Synthesis Service for WDR31 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR31 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR31 |
2 GenomeRNAi human phenotypes for WDR31:
|
Pathways & Interactions
for WDR31 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR31
|
Drugs & Compounds
for WDR31 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR31
Search CenterWatch for drugs/clinical trials and news about WDR31
|
Transcripts
for WDR31 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR31 gene (3 alternative transcripts): NM_001012361.2 NM_145241.3 NM_001006615.1 Unigene Cluster for WDR31: WD repeat domain 31 Hs.133331 [show with all ESTs]Unigene Representative Sequence: BC0123526 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374193(uc004bhc.3 uc004bhe.3 uc004bhd.3) ENST00000461942(uc004bhf.3)
ENST00000465205 ENST00000341761 ENST00000465979 ENST00000374195
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR31 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR31 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): WDR31 (NM_145241) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR31 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR31 |
Additional cDNA sequence: AK074891.1 AK093240.1 AK129868.1 AK313843.1 AL833635.1 BC012352.1 BC022982.1 4 DOTS entries: DT.99975519 DT.219379 DT.307283 DT.121146844 24/50 AceView cDNA sequences (see all 50): BF939192 BF589326 AK093240 BF939191 BM554244 NM_145241 AX748007 T84392 BE645646 BM554160 BG152821 BF939134 AI091187 BC012352 AI831366 AI052127 AA889286 BG539988 BF361157 BX114593 AA069026 AA448186 AA776710 AL833635
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for WDR31 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for WDR31
|
Expression
for WDR31 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR31 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTGGATTA
About this image
See WDR31 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR31
SOURCE GeneReport for Unigene cluster: Hs.133331
SABiosciences Custom PCR Arrays for WDR31
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR31
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR31 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR31 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR31 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR31 |
Orthologs
for WDR31 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for WDR31 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for WDR31 (if available)
TreeFam Gene Tree for WDR31 (if available) |
Paralogs
for WDR31 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WDR31 gene
- GNB2L12
4 SIMAP similar genes for WDR31 using alignment to 4 protein entries: WDR31_HUMAN (see all proteins):WDR83 GNB2L1 POC1B WSB1
WDR31 for paralogs About GeneDecksing
|
Genomic Variants
for WDR31 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR31 (116077930 - 116102620 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for WDR31
1 Indel: 60764 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR31 |
|
Disorders
/ Diseases
for WDR31 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 WDR31 for disorders About MalaCards
WDR31 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: WDR31 (2 documents)
Export disorders for WDR31 gene to outside databases
|
Publications
for WDR31 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR31 gene integrated from 9 sources:
(articles sorted by number of sources associating them with WDR31) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1 Luke M.M....Psaty B.M. (2009)
- Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1 Shiffman D....Psaty B.M. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The nucleotide sequence of phenylalanine tRNA2 of Drosophila melanogaster: four isoacceptors with one basic sequence. (PubMed id 114987)1 Altwegg M. and Kubli E. (1979)
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External Searches for WDR31 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR31 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR31 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR31 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR31 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR31 gene:
Search GeneIP for patents involving WDR31
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR31 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | WDR31 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR31 |
|  |  |  | | | | ThermoFisher Antibody for WDR31 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR31 |
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