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Aliases for WDR31 Gene

Aliases for WDR31 Gene

  • WD Repeat Domain 31 2 3 5
  • Similar To Spermatid WD-Repeat Protein 2

External Ids for WDR31 Gene

Previous GeneCards Identifiers for WDR31 Gene

  • GC09M111451
  • GC09M113155
  • GC09M115115
  • GC09M116077
  • GC09M085685

Summaries for WDR31 Gene

Entrez Gene Summary for WDR31 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR31 Gene

WDR31 (WD Repeat Domain 31) is a Protein Coding gene.

Additional gene information for WDR31 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR31 Gene

Genomics for WDR31 Gene

GeneHancer (GH) Regulatory Elements for WDR31 Gene

Promoters and enhancers for WDR31 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I113339 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 555.5 +0.2 182 1.7 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 WDR31 PRPF4 CDC26 BSPRY RNF183 RPL32P22 ALAD C9orf43 POLE3 HDHD3
GH09I113341 Enhancer 0.7 ENCODE 555.5 -1.5 -1546 0.2 GTF2F1 PKNOX1 NEUROD1 SIN3A RFX5 E2F1 ZNF335 CTBP1 PRDM10 FOSL2 WDR31 BSPRY
GH09I113342 Enhancer 0.6 ENCODE 550.8 -1.9 -1856 0.2 NFIB ZNF398 RFX5 E2F1 ZNF335 ZNF217 NFIC LCORL ZNF350 PRDM10 WDR31 BSPRY SLC31A1
GH09I113349 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 17.5 -10.1 -10096 2.7 SIN3A ZBTB40 RFX5 ZNF335 ELK1 ZSCAN5C ZNF143 FOS RCOR1 SMARCA5 BSPRY WDR31 ALAD RNF183 HDHD3
GH09I113274 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 13.7 +64.8 64780 2.5 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B PRPF4 CDC26 GC09P114623 PIR61584 WDR31 FKBP15 PTBP3 SLC31A2 RGS3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR31 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR31 gene promoter:

Genomic Locations for WDR31 Gene

Genomic Locations for WDR31 Gene
27,119 bases
Minus strand

Genomic View for WDR31 Gene

Genes around WDR31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR31 Gene

Proteins for WDR31 Gene

  • Protein details for WDR31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 31
    Protein Accession:
    Secondary Accessions:
    • Q5W0T9
    • Q96EG8

    Protein attributes for WDR31 Gene

    367 amino acids
    Molecular mass:
    40840 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR31 Gene


neXtProt entry for WDR31 Gene

Post-translational modifications for WDR31 Gene

No Post-translational modifications

No data available for DME Specific Peptides for WDR31 Gene

Domains & Families for WDR31 Gene

Gene Families for WDR31 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR31: view

No data available for UniProtKB/Swiss-Prot for WDR31 Gene

Function for WDR31 Gene

genes like me logo Genes that share phenotypes with WDR31: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR31 Gene

Localization for WDR31 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR31 gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR31 Gene

Pathways & Interactions for WDR31 Gene

SuperPathways for WDR31 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR31 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR31 Gene

Drugs & Compounds for WDR31 Gene

No Compound Related Data Available

Transcripts for WDR31 Gene

Unigene Clusters for WDR31 Gene

WD repeat domain 31:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR31 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: -
SP3: -
SP4: - -

Relevant External Links for WDR31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WDR31 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.4).

Protein differential expression in normal tissues from HIPED for WDR31 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR31 Gene

Protein tissue co-expression partners for WDR31 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR31 Gene:


SOURCE GeneReport for Unigene cluster for WDR31 Gene:

genes like me logo Genes that share expression patterns with WDR31: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR31 Gene

Orthologs for WDR31 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR31 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR31 33 34
  • 99.64 (n)
(Canis familiaris)
Mammalia WDR31 33
  • 89.22 (n)
-- 34
  • 85 (a)
-- 34
  • 79 (a)
(Bos Taurus)
Mammalia WDR31 33 34
  • 86.98 (n)
(Rattus norvegicus)
Mammalia Wdr31 33
  • 85.2 (n)
(Mus musculus)
Mammalia Wdr31 33 16 34
  • 85.1 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 76 (a)
-- 34
  • 55 (a)
(Monodelphis domestica)
Mammalia WDR31 34
  • 70 (a)
(Gallus gallus)
Aves WDR31 33 34
  • 66.08 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17269 33
(Danio rerio)
Actinopterygii si:ch73-266o15.4 33
  • 59.84 (n)
WDR31 34
  • 54 (a)
(Caenorhabditis elegans)
Secernentea T05A8.5 34
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ASC1 34
  • 20 (a)
Species where no ortholog for WDR31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for WDR31 Gene

Gene Tree for WDR31 (if available)
Gene Tree for WDR31 (if available)

Paralogs for WDR31 Gene

(4) SIMAP similar genes for WDR31 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with WDR31: view

No data available for Paralogs for WDR31 Gene

Variants for WDR31 Gene

Sequence variations from dbSNP and Humsavar for WDR31 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000177032 -- 113,325,262(-) G/A intron_variant
rs1000228024 -- 113,324,844(-) G/A intron_variant
rs1000332176 -- 113,316,393(-) C/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000535358 -- 113,339,472(-) T/C intron_variant
rs1000662775 -- 113,335,906(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR31 Gene

Variant ID Type Subtype PubMed ID
esv3342254 CNV insertion 20981092
esv3621540 CNV gain 21293372
esv6353 CNV gain 19470904
nsv521449 CNV loss 19592680

Variation tolerance for WDR31 Gene

Residual Variation Intolerance Score: 38.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.24; 81.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR31 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR31 Gene

Disorders for WDR31 Gene

Additional Disease Information for WDR31

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for WDR31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR31 Gene

Publications for WDR31 Gene

  1. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 44 58
  2. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for WDR31 Gene

Sources for WDR31 Gene

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