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WDR31 Gene

protein-coding GIFtS: 43

GC09M115115

WD repeat domain 31
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ35921 ^¹, ²
OTTHUMP00000021958 ^²

Descriptions
WD repeat domain 31 ^²

External Ids
HGNC: 21421¹
Entrez Gene: 114987²
UniProtKB: Q8NA23³
Ensembl: ENSG00000148225⁷

Search outside databases for aliases for WDR31 gene

Previous GC identifers: GC09M111451 GC09M113155

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for WDR31:

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved

regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which

may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are

involved in a variety of cellular processes, including cell cycle progression, signal

transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants

encoding distinct isoforms have been found for this gene but the biological validity of some

variants has not been determined. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the WDR31 gene

Entrez Gene cytogenetic band: 9q32 Ensembl cytogenetic band: 9q32 HGNC cytogenetic band: 9q33.1

WDR31 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M115115: (about GC identifiers)

Start:	115,117,751 bp from pter
End:	115,142,388 bp from pter
Size:	24,638 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_008470.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: WDR31_HUMAN, Q8NA23 (See protein sequence)

Recommended Name: WD repeat-containing protein 31

Size: 367 amino acids; 40840 Da

Secondary accessions: Q96EG8

Alternative splicing: 2 isoforms: Q8NA23-1 Q8NA23-2

REFSEQ proteins (3 alternative transcripts):

NP_001006616.1 NP_001012361.1 NP_660284.1

ENSEMBL proteins:

ENSP00000363310 ENSP00000345027 ENSP00000363308

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (WDR31)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for WDR31:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for WDR31
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for WDR31

Assays for WDR31:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8NA23

ProtoNet protein and cluster: Q8NA23

UniProtKB/Swiss-Prot: WDR31_HUMAN, Q8NA23

Similarity: Contains 5 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR31)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001006615

Applied Biosystems Silencer® siRNAs for WDR31

Sigma-Aldrich siRNA for WDR31

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for WDR31
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001006615
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001006615
untagged cDNA clones in CMV expression vector (see all 3): NM_001006615

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001012361

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR31

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR31)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001006615

Sigma-Aldrich siRNA for WDR31

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001006615 NM_001012361 NM_145241

REFSEQ mRNAs for WDR31 gene (3 alternative transcripts):

NM_001006615.1 NM_001012361.1 NM_145241.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001006615 NM_001012361 NM_145241

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001006615
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001006615
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001006615

Additional cDNA sequence:

AK074891.1 AK093240.1 AK129868.1 AK313843.1 AL833635.1 BC012352.1 BC022982.1

4 DOTS entries:

DT.99975519 DT.219379 DT.307283 DT.121146844

24/50 AceView cDNA sequences (see all 50 ):

BF939192 BF589326 NM_145241 BF939191 BF939134 BC012352 T84392 AK093240

BM554244 BE645646 AX748007 AI052127 AA889286 AI831366 BG152821 BM554160

AI091187 BG493868 BX114593 BG539988 BF361157 AW300479 BG033818 AA393383

highest scoring ESTs for WDR31:

AA776710 AI052127 AK074891 AK093240 AL833635 BC022982 BG470836 BI259351 BM541807 BM554160

Unigene Cluster for WDR31:

WD repeat domain 31

Hs.133331 [show with all ESTs]

Unigene Representative Sequence: BC012352

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for WDR31

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b
SP1:																					-
SP2:																					-
SP3:									-
SP4:											-										-

About this scheme

ECgene alternative splicing isoforms for WDR31

3 Ensembl transcripts including schematic representations:

ENST00000374195 ENST00000341761 ENST00000374193

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR31 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for WDR31

¹ / ² / ³

6 probe-sets matching WDR31 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
76763_at²^{, 3}	U95-E	1	1.00	1.00	0.83	1.05	AI052127	0.80	1.00	0.91	1
42222_at²^{, 3}	U95-B	1	1.00	1.00	0.70	0.97	AA776710	0.80	1.00	0.91	1
229516_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF589326	0.40	1.00	0.76	1
241919_x_at²^{, 3}	U133-B	3	0.46	0.87	--	--	BE870625	0.60	1.00	0.82	1
229516_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
241919_x_at²	U133Plus2	3	0.46	0.87	--	--	--	--	--	--	--

GeneDecks WDR31 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGCTGGATTA

SOURCE GeneReport for Unigene cluster: Hs.133331

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WDR31 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WDR31¹	--	WD repeat domain 31	89.16(n) 88.25(a)	612541 XM_850272.1 XP_855365.1
chimpanzee (Pan troglodytes)	WDR31¹	--	WD repeat domain 31	99.64(n) 99.73(a)	464673 XM_520200.2 XP_520200.2
cow (Bos taurus)	WDR31¹	--	WD repeat domain 31	86.92(n) 86.38(a)	528277 XM_606693.3 XP_606693.3
rat (Rattus norvegicus)	Wdr31¹	--	WD repeat domain 31	84.29(n) 82.17(a)	298096 NM_001011976.1 NP_001011976.1
mouse (Mus musculus)	Wdr31^{1, 5}	4⁵	WD repeat domain 31^{1, 5}	85.1(n)¹ 83.11(a)¹	71354¹ NM_023597.1¹ NP_076086.1¹ AF274321⁵ AK017259⁵ (see all 10)

About this table Species with no ortholog for WDR31

ENSEMBL Gene Tree for WDR31

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/145 NCBI SNPs in WDR31 are shown (see all 145 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 86)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs10817478^1,2	A,C,F,H	115118341(+)	`AGTGAT/CTGAAG`	3	--	ut3¹ ese³		7	NA EU EA WA	554
	rs7849513^1,2	A,C,F,H	115117632(+)	`GGACCT/AGTGAG`	3	--	ng5¹		4	EU EA WA	406
	rs10817479^1,2	C,F,H	115125244(+)	`TTTGGG/AAATAC`	3	S/P	mis¹ ut5¹		13	EU EA WA NA	1330
	rs17764563^1,2	C,F,H	115118289(+)	`CCAAGC/ATTTCG`	3	--	ut3¹ ese³		7	NA EU EA WA	552
	rs12350131^1,2	A,F,H	115143001(+)	`tgaatC/GaatGG`	3	--	ng3¹		3	EA WA	270
	rs7865438^1,2	C,F,H	115117993(+)	`TTATTT/CCAGGG`	3	--	ut3¹ spl³		7	EU EA WA NA	562
	rs16932583^1,2	C,F,H	115118192(+)	`GCTTCA/TAGCCA`	3	--	ut3¹ ese³		7	NA EU EA WA	556
	rs12684385^1,2	C,F,H	115117515(+)	`GGGACT/GTGTCA`	3	--	ng5¹		9	EU EA WA NA	742
	rs10981745^1,2	C,F,H	115144347(+)	`TTCAAA/GAGGCC`	3	--	ng3¹		8	EU EA WA	836
	rs10981736^1,2	C,F,H	115138522(+)	`TCTTCT/CCTGTC`	3	--	ut5¹ ese³ trp³		7	NA EU EA WA	556

About this table

HapMap Linkage Disequilibrium images for WDR31 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

Human Genome Epidemiology Navigator: WDR31 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for WDR31 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)³ Luke M.M....Psaty B.M. (2009)
Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)³ Shiffman D....Psaty B.M. (2008)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
The nucleotide sequence of phenylalanine tRNA2 of Drosophila melanogaster: four isoacceptors with one basic sequence. (PubMed id 114987)³ Altwegg M. and Kubli E. (1979)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 114987	HGNC: 21421	AceView: WDR31	Ensembl:ENSG00000148225	euGenes: HUgn114987
ECgene: WDR31	H-InvDB: WDR31

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for WDR31
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for WDR31:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for WDR31-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for WDR31		Antibodies for WDR31
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Browse shRNAs at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
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	Recombinant & Natural Proteins

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WDR31 Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for WDR31

Summaries
for WDR31

Genomic Location
for WDR31

Proteins
for WDR31

Protein Domains/
Families
for WDR31

Gene Function
for WDR31

Pathways & Interactions
for WDR31

Drugs & Compounds
for WDR31

Transcripts
for WDR31

Expression
for WDR31

Orthologs
for WDR31

Paralogs
for WDR31

SNPs/Variants
for WDR31

Disorders & Mutations
for WDR31

Medical News
for WDR31

Publications
for WDR31

Search for WDR31

Genome Databases showing WDR31

Other Databases showing WDR31

Specialized Databases showing WDR31

Licensable Technologies
for WDR31

Services
for WDR31

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WDR31 Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor WDR31

Summariesfor WDR31

Genomic Locationfor WDR31

Proteinsfor WDR31

Protein Domains/Familiesfor WDR31

Gene Functionfor WDR31

Pathways & Interactionsfor WDR31

Drugs & Compoundsfor WDR31

Transcriptsfor WDR31

Expression for WDR31

Orthologsfor WDR31

Paralogsfor WDR31

SNPs/Variantsfor WDR31

Disorders & Mutationsfor WDR31

Medical Newsfor WDR31

Publicationsfor WDR31

Search for WDR31

Genome Databases showing WDR31

Other Databases showing WDR31

Specialized Databases showing WDR31

Licensable Technologiesfor WDR31

Servicesfor WDR31

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for WDR31

Summaries
for WDR31

Genomic Location
for WDR31

Proteins
for WDR31

Protein Domains/
Families
for WDR31

Gene Function
for WDR31

Pathways & Interactions
for WDR31

Drugs & Compounds
for WDR31

Transcripts
for WDR31

Expression
for WDR31

Orthologs
for WDR31

Paralogs
for WDR31

SNPs/Variants
for WDR31

Disorders & Mutations
for WDR31

Medical News
for WDR31

Publications
for WDR31

Licensable Technologies
for WDR31

Services
for WDR31