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Aliases for WDR3 Gene

Aliases for WDR3 Gene

  • WD Repeat Domain 3 2 3 5
  • WD Repeat-Containing Protein 3 3
  • DJ776P7.2 (WD Repeat Domain 3) 3
  • UTP12 3
  • DIP2 3

External Ids for WDR3 Gene

Previous GeneCards Identifiers for WDR3 Gene

  • GC01P118934
  • GC01P117313
  • GC01P117622
  • GC01P117822
  • GC01P117818
  • GC01P118184
  • GC01P118472
  • GC01P116328

Summaries for WDR3 Gene

Entrez Gene Summary for WDR3 Gene

  • This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR3 Gene

WDR3 (WD Repeat Domain 3) is a Protein Coding gene. Among its related pathways are rRNA processing and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and snoRNA binding. An important paralog of this gene is CSTF1.

Gene Wiki entry for WDR3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR3 Gene

Genomics for WDR3 Gene

Regulatory Elements for WDR3 Gene

Enhancers for WDR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around WDR3 on UCSC Golden Path with GeneCards custom track

Promoters for WDR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR3 Gene

Chromosome:
1
Start:
117,929,720 bp from pter
End:
117,966,542 bp from pter
Size:
36,823 bases
Orientation:
Plus strand

Genomic View for WDR3 Gene

Genes around WDR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR3 Gene

Proteins for WDR3 Gene

  • Protein details for WDR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNX4-WDR3_HUMAN
    Recommended name:
    WD repeat-containing protein 3
    Protein Accession:
    Q9UNX4

    Protein attributes for WDR3 Gene

    Size:
    943 amino acids
    Molecular mass:
    106099 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WDR3 Gene

Post-translational modifications for WDR3 Gene

  • Ubiquitination at Lys 57 and Lys 521
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR3 Gene

Domains & Families for WDR3 Gene

Gene Families for WDR3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UNX4

UniProtKB/Swiss-Prot:

WDR3_HUMAN :
  • Belongs to the WD repeat WDR3/UTP12 family.
  • Contains 13 WD repeats.
Family:
  • Belongs to the WD repeat WDR3/UTP12 family.
Similarity:
  • Contains 13 WD repeats.
genes like me logo Genes that share domains with WDR3: view

Function for WDR3 Gene

Molecular function for WDR3 Gene

GENATLAS Biochemistry:
WD repeat domain 3,expressed in hematopoietic cell lines and in non hematopoietic tissues,involved in cell cycle progression,apoptosis gene regulation

Gene Ontology (GO) - Molecular Function for WDR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030515 snoRNA binding IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with WDR3: view
genes like me logo Genes that share phenotypes with WDR3: view

Animal Models for WDR3 Gene

MGI Knock Outs for WDR3:
  • Wdr3 tm1a(KOMP)Wtsi

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR3 Gene

Localization for WDR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR3 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR3 Gene COMPARTMENTS Subcellular localization image for WDR3 gene
Compartment Confidence
nucleus 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for WDR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0031965 nuclear membrane IDA --
GO:0032040 small-subunit processome IBA --
genes like me logo Genes that share ontologies with WDR3: view

Pathways & Interactions for WDR3 Gene

genes like me logo Genes that share pathways with WDR3: view

Pathways by source for WDR3 Gene

Gene Ontology (GO) - Biological Process for WDR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with WDR3: view

No data available for SIGNOR curated interactions for WDR3 Gene

Drugs & Compounds for WDR3 Gene

No Compound Related Data Available

Transcripts for WDR3 Gene

Unigene Clusters for WDR3 Gene

WD repeat domain 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
SP1:
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7: - - - -
SP8: - - -
SP9: -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for WDR3 Gene

GeneLoc Exon Structure for
WDR3
ECgene alternative splicing isoforms for
WDR3

Expression for WDR3 Gene

mRNA expression in normal human tissues for WDR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.2) and Urine (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR3 Gene



Protein tissue co-expression partners for WDR3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR3 Gene:

WDR3

SOURCE GeneReport for Unigene cluster for WDR3 Gene:

Hs.310809

mRNA Expression by UniProt/SwissProt for WDR3 Gene:

Q9UNX4-WDR3_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with WDR3: view

Primer Products

No data available for mRNA differential expression in normal tissues for WDR3 Gene

Orthologs for WDR3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR3 34
  • 91.06 (n)
  • 94.49 (a)
WDR3 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR3 34
  • 90.07 (n)
  • 93.43 (a)
WDR3 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr3 34
  • 85.72 (n)
  • 91.18 (a)
Wdr3 16
Wdr3 35
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR3 34
  • 99.58 (n)
  • 99.47 (a)
WDR3 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr3 34
  • 84.84 (n)
  • 90.65 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR3 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR3 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR3 34
  • 75.12 (n)
  • 80.17 (a)
WDR3 35
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR3 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76073 34
wdr3 34
  • 68.67 (n)
  • 75.16 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4834 34
zebrafish
(Danio rerio)
Actinopterygii wdr3 34
  • 68.66 (n)
  • 72.19 (a)
wdr3 35
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8064 36
  • 41 (a)
CG8064 34
  • 50.87 (n)
  • 44.9 (a)
CG8064 35
  • 43 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001146 34
  • 51.16 (n)
  • 45.51 (a)
worm
(Caenorhabditis elegans)
Secernentea F13H8.2 36
  • 33 (a)
F13H8.2 34
  • 48.93 (n)
  • 35.96 (a)
F13H8.2 35
  • 34 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL196C 34
  • 48.64 (n)
  • 39.86 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16390g 34
  • 49.6 (n)
  • 40.3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIP2 34
  • 51.06 (n)
  • 42.39 (a)
DIP2 35
  • 37 (a)
OneToMany
DIP2 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G21540 34
  • 50.23 (n)
  • 42.57 (a)
rice
(Oryza sativa)
Liliopsida Os.9622 34
Os03g0151700 34
  • 50.31 (n)
  • 40.67 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13 34
bread mold
(Neurospora crassa)
Ascomycetes NCU03051 34
  • 49.41 (n)
  • 42.09 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC3D6.12 34
  • 51.26 (n)
  • 43.26 (a)
Species where no ortholog for WDR3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR3 Gene

ENSEMBL:
Gene Tree for WDR3 (if available)
TreeFam:
Gene Tree for WDR3 (if available)

Paralogs for WDR3 Gene

Paralogs for WDR3 Gene

genes like me logo Genes that share paralogs with WDR3: view

Variants for WDR3 Gene

Sequence variations from dbSNP and Humsavar for WDR3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3738420 - 117,940,851(+) CAGAC(C/G)CCAAG reference, missense
rs1321666 -- 117,949,429(+) ACAAA(C/T)CTAGA intron-variant
rs2295627 -- 117,949,330(+) TGAGA(C/G)TAATT intron-variant
rs2295628 -- 117,949,600(+) AAAGA(G/T)CAGTG intron-variant
rs2295629 -- 117,949,904(+) TTGAC(A/G)TCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR3 Gene

Variant ID Type Subtype PubMed ID
esv34191 CNV loss 18971310
nsv528470 CNV loss 19592680
nsv547611 CNV loss 21841781

Variation tolerance for WDR3 Gene

Residual Variation Intolerance Score: 5.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.98; 84.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR3 Gene

Disorders for WDR3 Gene

Relevant External Links for WDR3

Genetic Association Database (GAD)
WDR3
Human Genome Epidemiology (HuGE) Navigator
WDR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR3

No disorders were found for WDR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR3 Gene

Publications for WDR3 Gene

  1. Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13. (PMID: 10395803) Claudio J.O. … Hawley R.G. (Genomics 1999) 2 3 4 65
  2. WDR3 gene haplotype is associated with thyroid cancer risk in a Spanish population. (PMID: 20578902) Akdi A. … VelA!zquez A. (Thyroid 2010) 3 46 65
  3. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4 65
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3 65
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 65

Products for WDR3 Gene

Sources for WDR3 Gene

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