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WDR3 Gene

protein-coding   GIFtS: 59
GCID: GC01P118472

WD Repeat Domain 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 31 2
DIP22
UTP122
DJ776P7.2 (WD Repeat Domain 3)2
WD Repeat-Containing Protein 32

External Ids:    HGNC: 127551   Entrez Gene: 108852   Ensembl: ENSG000000651837   OMIM: 6047375   UniProtKB: Q9UNX43   

Export aliases for WDR3 gene to outside databases

Previous GC identifers: GC01P118934 GC01P117313 GC01P117622 GC01P117822 GC01P117818 GC01P118184 GC01P116328


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WDR3 Gene:
This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid
domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins
belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle
progression, signal transduction, apoptosis, and gene regulation. (provided by RefSeq, Jul 2008)

GeneCards Summary for WDR3 Gene:
WDR3 (WD repeat domain 3) is a protein-coding gene. An important paralog of this gene is APAF1.

Gene Wiki entry for WDR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR3 gene promoter:
         AP-1   FOXD3   LCR-F1   HNF-1A   Roaz   GATA-1   HEN1   Pax-3   HNF-1   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR3 promoter sequence
   Search Chromatin IP Primers for WDR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p12   Ensembl cytogenetic band:  1p12   HGNC cytogenetic band: 1p12

WDR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P118472:  view genomic region     (about GC identifiers)

Start:
118,472,343 bp from pter      End:
118,509,165 bp from pter
Size:
36,823 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WDR3_HUMAN, Q9UNX4 (See protein sequence)
Recommended Name: WD repeat-containing protein 3  
Size: 943 amino acids; 106099 Da

Explore the universe of human proteins at neXtProt for WDR3: NX_Q9UNX4

Explore proteomics data for WDR3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys57, Lys521
  • Modification sites at PhosphoSitePlus

  • See WDR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006775.1  
    ENSEMBL proteins: 
     ENSP00000308179   ENSP00000358449  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR007148 SSU_processome_Utp12
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q9UNX4

    ProtoNet protein and cluster: Q9UNX4

    1 Blocks protein domain: IPB007148 Dip2/Utp12

    UniProtKB/Swiss-Prot: WDR3_HUMAN, Q9UNX4
    Similarity: Belongs to the WD repeat WDR3/UTP12 family
    Similarity: Contains 13 WD repeats


    Find genes that share domains with WDR3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for WDR3:
    WD repeat domain 3,expressed in hematopoietic cell lines and in non hematopoietic tissues,involved in cell cycle
    progression,apoptosis gene regulation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with WDR3           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for WDR3:
     Decreased viability of wild-ty  Nuclear pre-40S maturation def  Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Wdr3):
     mortality/aging 

    Find genes that share phenotypes with WDR3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDR3
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    miRTarBase miRNAs that target WDR3:
    hsa-let-7b-5p (MIRT052227), hsa-let-7c-5p (MIRT051837), hsa-mir-16-5p (MIRT031533)

    Block miRNA regulation of human, mouse, rat WDR3 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate WDR3:
    hsa-miR-203 hsa-miR-320a hsa-miR-320b hsa-miR-320d hsa-let-7f-2*
    SwitchGear 3'UTR luciferase reporter plasmidWDR3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WDR3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WDR3_HUMAN, Q9UNX4: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    endoplasmic reticulum1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0031965nuclear membrane IDA--

    Find genes that share ontologies with WDR3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WDR3 About    
    See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes


    Find genes that share SuperPaths with WDR3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for WDR3):
        Ribosome biogenesis in eukaryotes

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR3
    Interactions:

        Search GeneGlobe Interaction Network for WDR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WDR3 (Q9UNX42, 3 ENSP000003081794) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDR3 gene: 
    NM_006784.2  

    Unigene Cluster for WDR3:

    WD repeat domain 3
    Hs.310809  [show with all ESTs]
    Unigene Representative Sequence: NM_006784
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487202 ENST00000349139(uc001ehi.2 uc010oxe.1) ENST00000471680
    ENST00000369441(uc001ehh.2)
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate WDR3:
    hsa-miR-203 hsa-miR-320a hsa-miR-320b hsa-miR-320d hsa-let-7f-2*
    SwitchGear 3'UTR luciferase reporter plasmidWDR3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WDR3
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    GenScript: all cDNA clones in your preferred vector: WDR3 (NM_006784)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for WDR3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR3
      QuantiTect SYBR Green Assays in human, mouse, rat WDR3
      QuantiFast Probe-based Assays in human, mouse, rat WDR3

    Additional mRNA sequence: 

    AB209201.1 AF083217.1 AK022858.1 AK292438.1 BC058836.1 BC128385.1 BC128454.1 BC148244.1 

    11 DOTS entries:

    DT.95370125  DT.412006  DT.121463746  DT.100022302  DT.100748877  DT.319947  DT.302646  DT.40290469 
    DT.423063  DT.95271952  DT.206431 

    Selected AceView cDNA sequences (see all 111):

    AU124711 AA514680 AI624692 BF062207 BU160827 BM471651 BF445663 AI697107 
    AA417908 BU167311 CR620639 AA743286 BG105708 BE745523 AU124009 AI696723 
    AI492156 CB244006 AA916500 AI922229 H42014 AA481532 H42013 BE505015 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WDR3 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
    SP1:                                                                                                                                                            
    SP2:              -     -     -           -                                                                                                                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                                                                          -         
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for WDR3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCTTAGAG
    WDR3 Expression
    About this image


    WDR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    WDR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.310809

    UniProtKB/Swiss-Prot: WDR3_HUMAN, Q9UNX4
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for WDR3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDR3 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr31 , 5 WD repeat domain 31, 5 85.72(n)1
    91.18(a)1
      3 (43.46 cM)5
    2694701  NM_175552.41  NP_780761.11 
     1001381805 
    chicken
    (Gallus gallus)
    Aves WDR31 WD repeat domain 3 75.12(n)
    80.17(a)
      427952  NM_001031485.1  NP_001026656.1 
    lizard
    (Anolis carolinensis)
    Reptilia WDR36
    WD repeat domain 3
    75(a)
    1 ↔ 1
    GL343218.1(879296-910320)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.48342 Xenopus laevis transcribed sequence with moderate similarity more 74.82(n)    CD303393.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wdr32 WD repeat domain 3 75.68(n)   321058  BC057490.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG80641 , 3 CG80641 41(a)3
    50.87(n)1
    44.9(a)1
      91A13
    421961  NM_142448.31  NP_650705.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F13H8.21 , 3 beta transducin Trp-Asp domains3
    F13H8.21
    33(a)3
    48.93(n)1
    35.96(a)1
      II(6270322-6273677)3
    1740381  NM_062855.41  NP_495256.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DIP2(YLR129W)4
    DIP21
    Nucleolar protein, specifically associated with the more4
    DIP21
    51.06(n)1
    42.39(a)1
      12(399657-402488)4
    8508201, 4  NP_013230.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G215401 AT3G21540 50.23(n)
    42.57(a)
      821708  NM_113049.3  NP_188791.3 
    rice
    (Oryza sativa)
    Liliopsida Os.96222 Oryza sativa (japonica cultivar-group) isolate 29961 more 75.27(n)    AK101270.1 


    ENSEMBL Gene Tree for WDR3 (if available)
    TreeFam Gene Tree for WDR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR3 gene
    APAF12  

    Find genes that share paralogs with WDR3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR3 (see all 494)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1474250271,2
    --118474354(+) GAGTCC/TGGAGG 1 -- int10--------
    rs1381049501,2
    C--118474381(+) AAAGAA/GTTAAT 1 -- int10--------
    rs1874453541,2
    --118474464(+) TGGTTC/TCTGTG 1 -- int10--------
    rs170377541,2
    C,F,H--118474542(+) TTTTTG/TTGTTA 1 -- int118Minor allele frequency- T:0.08NA NS EA WA CSA 2119
    rs1129492001,2
    C--118474542(+) TTTTTG/-TGTTA 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1855265761,2
    --118474558(+) AAACAA/GCATTT 1 -- int10--------
    rs1904291781,2
    C--118474601(+) ACCAAA/CCAAAG 1 -- int10--------
    rs1816595641,2
    --118474635(+) AAACAA/GCTCCT 1 -- int10--------
    rs1163725361,2
    C,F--118474642(+) TCCTCA/GTAAAA 1 -- int11Minor allele frequency- G:0.05WA 118
    rs1161729481,2
    C,F--118474688(+) GCATGG/AGTGTT 1 -- int11Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for WDR3 (118472343 - 118509165 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for WDR3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34191CNV Loss18971310
    nsv528470CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604737    OMIM disorders: --


    Find genes that share disorders with WDR3           About GenesLikeMe

    Genetic Association Database (GAD): WDR3
    Human Genome Epidemiology (HuGE) Navigator: WDR3 (1 document)

    Export disorders for WDR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR3 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with WDR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13. (PubMed id 10395803)1, 2, 3 Claudio J.O....Hawley R.G. (Genomics 1999)
    2. WDR3 gene haplotype is associated with thyroid cancer risk in a Spanish population. (PubMed id 20578902)1, 4 Akdi A....VelA!zquez A. (Thyroid 2010)
    3. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    4. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (amp 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (J Proteomics 2012)
    9. Possible role of the WDR3 gene on genome stability in thyroid cancer patients. (PubMed id 23049746)1 GarcA-a-Quispes W.A....Marcos R. (PLoS ONE 2012)
    10. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10885 HGNC: 12755 AceView: WDR3 Ensembl:ENSG00000065183 euGenes: HUgn10885
    ECgene: WDR3 Kegg: 10885 H-InvDB: WDR3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WDR3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDR3 gene:
    Search GeneIP for patents involving WDR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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