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Aliases for WDR3 Gene

Aliases for WDR3 Gene

  • WD Repeat Domain 3 2 3
  • DJ776P7.2 (WD Repeat Domain 3) 3
  • UTP12 3
  • DIP2 3

External Ids for WDR3 Gene

Previous GeneCards Identifiers for WDR3 Gene

  • GC01P118934
  • GC01P117313
  • GC01P117622
  • GC01P117822
  • GC01P117818
  • GC01P118184
  • GC01P118472
  • GC01P116328

Summaries for WDR3 Gene

Entrez Gene Summary for WDR3 Gene

  • This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR3 Gene

WDR3 (WD Repeat Domain 3) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include poly(A) RNA binding and snoRNA binding. An important paralog of this gene is APAF1.

Gene Wiki entry for WDR3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR3 Gene

Genomics for WDR3 Gene

Regulatory Elements for WDR3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WDR3 Gene

Chromosome:
1
Start:
117,929,720 bp from pter
End:
117,966,542 bp from pter
Size:
36,823 bases
Orientation:
Plus strand

Genomic View for WDR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for WDR3 Gene

Proteins for WDR3 Gene

  • Protein details for WDR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNX4-WDR3_HUMAN
    Recommended name:
    WD repeat-containing protein 3
    Protein Accession:
    Q9UNX4

    Protein attributes for WDR3 Gene

    Size:
    943 amino acids
    Molecular mass:
    106099 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WDR3 Gene

Proteomics data for WDR3 Gene at MOPED

Post-translational modifications for WDR3 Gene

  • Ubiquitination at Lys 57 and Lys 521
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR3 Gene

Domains & Families for WDR3 Gene

Gene Families for WDR3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UNX4

UniProtKB/Swiss-Prot:

WDR3_HUMAN :
  • Belongs to the WD repeat WDR3/UTP12 family.
  • Contains 13 WD repeats.
Family:
  • Belongs to the WD repeat WDR3/UTP12 family.
Similarity:
  • Contains 13 WD repeats.
genes like me logo Genes that share domains with WDR3: view

Function for WDR3 Gene

Molecular function for WDR3 Gene

GENATLAS Biochemistry:
WD repeat domain 3,expressed in hematopoietic cell lines and in non hematopoietic tissues,involved in cell cycle progression,apoptosis gene regulation

Gene Ontology (GO) - Molecular Function for WDR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0030515 snoRNA binding IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with WDR3: view
genes like me logo Genes that share phenotypes with WDR3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR3 Gene

Localization for WDR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR3 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR3 Gene COMPARTMENTS Subcellular localization image for WDR3 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for WDR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0031965 nuclear membrane IDA --
GO:0032040 small-subunit processome IBA --
GO:0034388 Pwp2p-containing subcomplex of 90S preribosome IBA --
genes like me logo Genes that share ontologies with WDR3: view

Pathways & Interactions for WDR3 Gene

genes like me logo Genes that share pathways with WDR3: view

Pathways by source for WDR3 Gene

1 KEGG pathway for WDR3 Gene

Gene Ontology (GO) - Biological Process for WDR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
genes like me logo Genes that share ontologies with WDR3: view

No data available for SIGNOR curated interactions for WDR3 Gene

Drugs & Compounds for WDR3 Gene

No Compound Related Data Available

Transcripts for WDR3 Gene

Unigene Clusters for WDR3 Gene

WD repeat domain 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
SP1:
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7: - - - -
SP8: - - -
SP9: -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for WDR3 Gene

GeneLoc Exon Structure for
WDR3
ECgene alternative splicing isoforms for
WDR3

Expression for WDR3 Gene

mRNA expression in normal human tissues for WDR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.2) and Urine (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR3 Gene



SOURCE GeneReport for Unigene cluster for WDR3 Gene Hs.310809

mRNA Expression by UniProt/SwissProt for WDR3 Gene

Q9UNX4-WDR3_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expression patterns with WDR3: view

Protein tissue co-expression partners for WDR3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for WDR3 Gene

Orthologs for WDR3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR3 35
  • 91.06 (n)
  • 94.49 (a)
WDR3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR3 35
  • 90.07 (n)
  • 93.43 (a)
WDR3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr3 35
  • 85.72 (n)
  • 91.18 (a)
Wdr3 16
Wdr3 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR3 35
  • 99.58 (n)
  • 99.47 (a)
WDR3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr3 35
  • 84.84 (n)
  • 90.65 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR3 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR3 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR3 35
  • 75.12 (n)
  • 80.17 (a)
WDR3 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR3 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76073 35
wdr3 35
  • 68.67 (n)
  • 75.16 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4834 35
zebrafish
(Danio rerio)
Actinopterygii wdr3 35
  • 68.66 (n)
  • 72.19 (a)
wdr3 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8064 37
  • 41 (a)
CG8064 35
  • 50.87 (n)
  • 44.9 (a)
CG8064 36
  • 43 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001146 35
  • 51.16 (n)
  • 45.51 (a)
worm
(Caenorhabditis elegans)
Secernentea F13H8.2 37
  • 33 (a)
F13H8.2 35
  • 48.93 (n)
  • 35.96 (a)
F13H8.2 36
  • 34 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL196C 35
  • 48.64 (n)
  • 39.86 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16390g 35
  • 49.6 (n)
  • 40.3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIP2 35
  • 51.06 (n)
  • 42.39 (a)
DIP2 36
  • 37 (a)
OneToMany
DIP2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G21540 35
  • 50.23 (n)
  • 42.57 (a)
rice
(Oryza sativa)
Liliopsida Os.9622 35
Os03g0151700 35
  • 50.31 (n)
  • 40.67 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03051 35
  • 49.41 (n)
  • 42.09 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC3D6.12 35
  • 51.26 (n)
  • 43.26 (a)
Species with no ortholog for WDR3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR3 Gene

ENSEMBL:
Gene Tree for WDR3 (if available)
TreeFam:
Gene Tree for WDR3 (if available)

Paralogs for WDR3 Gene

Paralogs for WDR3 Gene

genes like me logo Genes that share paralogs with WDR3: view

Variants for WDR3 Gene

Sequence variations from dbSNP and Humsavar for WDR3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1321666 -- 117,949,429(+) ACAAA(C/T)CTAGA intron-variant
rs2273579 -- 117,953,003(+) TAAGT(A/G)AATTT intron-variant
rs2295627 -- 117,949,330(+) TGAGA(C/G)TAATT intron-variant
rs2295628 -- 117,949,600(+) AAAGA(G/T)CAGTG intron-variant
rs2295629 -- 117,949,904(+) TTGAC(A/G)TCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR3 Gene

Variant ID Type Subtype PubMed ID
nsv528470 CNV Loss 19592680
esv34191 CNV Loss 18971310

Variation tolerance for WDR3 Gene

Residual Variation Intolerance Score: 5.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.98; 84.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR3 Gene

HapMap Linkage Disequilibrium report
WDR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR3 Gene

Disorders for WDR3 Gene

Relevant External Links for WDR3

Genetic Association Database (GAD)
WDR3
Human Genome Epidemiology (HuGE) Navigator
WDR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR3
genes like me logo Genes that share disorders with WDR3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR3 Gene

Publications for WDR3 Gene

  1. Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13. (PMID: 10395803) Claudio J.O. … Hawley R.G. (Genomics 1999) 2 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  3. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 67
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 67
  5. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 67

Products for WDR3 Gene

Sources for WDR3 Gene

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