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Aliases for WDR3 Gene

Aliases for WDR3 Gene

  • WD Repeat Domain 3 2 3
  • WD Repeat-Containing Protein 3 3
  • DJ776P7.2 (WD Repeat Domain 3) 3
  • UTP12 3
  • DIP2 3

External Ids for WDR3 Gene

Previous GeneCards Identifiers for WDR3 Gene

  • GC01P118934
  • GC01P117313
  • GC01P117622
  • GC01P117822
  • GC01P117818
  • GC01P118184
  • GC01P118472
  • GC01P116328

Summaries for WDR3 Gene

Entrez Gene Summary for WDR3 Gene

  • This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR3 Gene

WDR3 (WD Repeat Domain 3) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. An important paralog of this gene is APAF1.

Gene Wiki entry for WDR3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR3 Gene

Genomics for WDR3 Gene

Regulatory Elements for WDR3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WDR3 Gene

117,929,720 bp from pter
117,966,542 bp from pter
36,823 bases
Plus strand

Genomic View for WDR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR3 Gene

Proteins for WDR3 Gene

  • Protein details for WDR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 3
    Protein Accession:
    Secondary Accessions:

    Protein attributes for WDR3 Gene

    943 amino acids
    Molecular mass:
    106099 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WDR3 Gene

Proteomics data for WDR3 Gene at MOPED

Post-translational modifications for WDR3 Gene

  • Ubiquitination at Lys57 and Lys521
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR3 Gene

Domains for WDR3 Gene

Gene Families for WDR3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat WDR3/UTP12 family.
  • Contains 13 WD repeats.
  • Belongs to the WD repeat WDR3/UTP12 family.
  • Contains 13 WD repeats.
genes like me logo Genes that share domains with WDR3: view

Function for WDR3 Gene

Molecular function for WDR3 Gene

GENATLAS Biochemistry:
WD repeat domain 3,expressed in hematopoietic cell lines and in non hematopoietic tissues,involved in cell cycle progression,apoptosis gene regulation

Gene Ontology (GO) - Molecular Function for WDR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0030515 snoRNA binding IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with WDR3: view
genes like me logo Genes that share phenotypes with WDR3: view

Animal Model Products

miRNA for WDR3 Gene

miRTarBase miRNAs that target WDR3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR3 Gene

Localization for WDR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR3 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for WDR3 Gene COMPARTMENTS Subcellular localization image for WDR3 gene
Compartment Confidence
nucleus 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for WDR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0031965 nuclear membrane IDA --
GO:0032040 small-subunit processome IBA --
GO:0034388 Pwp2p-containing subcomplex of 90S preribosome IBA --
genes like me logo Genes that share ontologies with WDR3: view

Pathways for WDR3 Gene

genes like me logo Genes that share pathways with WDR3: view

Pathways by source for WDR3 Gene

1 KEGG pathway for WDR3 Gene

Gene Ontology (GO) - Biological Process for WDR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
genes like me logo Genes that share ontologies with WDR3: view

Transcripts for WDR3 Gene

Unigene Clusters for WDR3 Gene

WD repeat domain 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
SP2: - - - -
SP7: - - - -
SP8: - - -
SP9: -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
SP3: -

Relevant External Links for WDR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR3 Gene

mRNA expression in normal human tissues for WDR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for WDR3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.2) and Urine (12.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR3 Gene

SOURCE GeneReport for Unigene cluster for WDR3 Gene Hs.310809

mRNA Expression by UniProt/SwissProt for WDR3 Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with WDR3: view

Expression partners for WDR3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for WDR3 Gene

Orthologs for WDR3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR3 35
  • 91.06 (n)
  • 94.49 (a)
WDR3 36
  • 94 (a)
(Canis familiaris)
Mammalia WDR3 35
  • 90.07 (n)
  • 93.43 (a)
WDR3 36
  • 91 (a)
(Mus musculus)
Mammalia Wdr3 35
  • 85.72 (n)
  • 91.18 (a)
Wdr3 16
Wdr3 36
  • 91 (a)
(Pan troglodytes)
Mammalia WDR3 35
  • 99.58 (n)
  • 99.47 (a)
WDR3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Wdr3 35
  • 84.84 (n)
  • 90.65 (a)
(Monodelphis domestica)
Mammalia WDR3 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia WDR3 36
  • 77 (a)
(Gallus gallus)
Aves WDR3 35
  • 75.12 (n)
  • 80.17 (a)
WDR3 36
  • 80 (a)
(Anolis carolinensis)
Reptilia WDR3 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76073 35
wdr3 35
  • 68.67 (n)
  • 75.16 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4834 35
(Danio rerio)
Actinopterygii wdr3 35
  • 68.66 (n)
  • 72.19 (a)
wdr3 36
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8064 37
  • 41 (a)
CG8064 35
  • 50.87 (n)
  • 44.9 (a)
CG8064 36
  • 43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001146 35
  • 51.16 (n)
  • 45.51 (a)
(Caenorhabditis elegans)
Secernentea F13H8.2 37
  • 33 (a)
F13H8.2 35
  • 48.93 (n)
  • 35.96 (a)
F13H8.2 36
  • 34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL196C 35
  • 48.64 (n)
  • 39.86 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16390g 35
  • 49.6 (n)
  • 40.3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIP2 35
  • 51.06 (n)
  • 42.39 (a)
DIP2 36
  • 37 (a)
DIP2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G21540 35
  • 50.23 (n)
  • 42.57 (a)
(Oryza sativa)
Liliopsida Os.9622 35
Os03g0151700 35
  • 50.31 (n)
  • 40.67 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03051 35
  • 49.41 (n)
  • 42.09 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC3D6.12 35
  • 51.26 (n)
  • 43.26 (a)
Species with no ortholog for WDR3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR3 Gene

Gene Tree for WDR3 (if available)
Gene Tree for WDR3 (if available)

Paralogs for WDR3 Gene

Paralogs for WDR3 Gene

genes like me logo Genes that share paralogs with WDR3: view

Variants for WDR3 Gene

Sequence variations from dbSNP and Humsavar for WDR3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1321666 -- 117,949,429(+) ACAAA(C/T)CTAGA intron-variant
rs2273579 -- 117,953,003(+) TAAGT(A/G)AATTT intron-variant
rs2295627 -- 117,949,330(+) TGAGA(C/G)TAATT intron-variant
rs2295628 -- 117,949,600(+) AAAGA(G/T)CAGTG intron-variant
rs2295629 -- 117,949,904(+) TTGAC(A/G)TCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR3 Gene

Variant ID Type Subtype PubMed ID
nsv528470 CNV Loss 19592680
esv34191 CNV Loss 18971310

Relevant External Links for WDR3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR3 Gene

Disorders for WDR3 Gene

Relevant External Links for WDR3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for WDR3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for WDR3 Gene

Publications for WDR3 Gene

  1. Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13. (PMID: 10395803) Claudio J.O. … Hawley R.G. (Genomics 1999) 2 3 4
  2. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  3. WDR3 gene haplotype is associated with thyroid cancer risk in a Spanish population. (PMID: 20578902) Akdi A. … VelA!zquez A. (Thyroid 2010) 3 48
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. Purification and identification of endogenous polySUMO conjugates. (PMID: 21252943) Bruderer R. … Hay R.T. (EMBO Rep. 2011) 3

Products for WDR3 Gene

Sources for WDR3 Gene

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