Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDR27 Gene

Aliases for WDR27 Gene

  • WD Repeat Domain 27 2 3 5

External Ids for WDR27 Gene

Previous GeneCards Identifiers for WDR27 Gene

  • GC00U914116
  • GC06M169675
  • GC06M169857
  • GC06M167278
  • GC06M169457

Summaries for WDR27 Gene

Entrez Gene Summary for WDR27 Gene

  • This gene encodes a protein with multiple WD repeats. Proteins with these repeats may form scaffolds for protein-protein interaction and play key roles in cell signalling. Alternative splicing results in multiple transcript variants, but the full-length structure of some of these variants cannot be determined. [provided by RefSeq, Nov 2015]

GeneCards Summary for WDR27 Gene

WDR27 (WD Repeat Domain 27) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR27 Gene

Genomics for WDR27 Gene

Regulatory Elements for WDR27 Gene

Enhancers for WDR27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around WDR27 on UCSC Golden Path with GeneCards custom track

Promoters for WDR27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR27 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR27 Gene

Chromosome:
6
Start:
169,426,407 bp from pter
End:
169,702,063 bp from pter
Size:
275,657 bases
Orientation:
Minus strand

Genomic View for WDR27 Gene

Genes around WDR27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR27 Gene

Proteins for WDR27 Gene

  • Protein details for WDR27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RRH5-WDR27_HUMAN
    Recommended name:
    WD repeat-containing protein 27
    Protein Accession:
    A2RRH5
    Secondary Accessions:
    • A5PLM8
    • C9JGV0
    • Q5T066

    Protein attributes for WDR27 Gene

    Size:
    827 amino acids
    Molecular mass:
    90038 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR27 Gene

Post-translational modifications for WDR27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR27 Gene

No data available for DME Specific Peptides for WDR27 Gene

Domains & Families for WDR27 Gene

Gene Families for WDR27 Gene

Protein Domains for WDR27 Gene

Suggested Antigen Peptide Sequences for WDR27 Gene

Graphical View of Domain Structure for InterPro Entry

A2RRH5

UniProtKB/Swiss-Prot:

WDR27_HUMAN :
  • Contains 10 WD repeats.
Similarity:
  • Contains 10 WD repeats.
genes like me logo Genes that share domains with WDR27: view

Function for WDR27 Gene

Gene Ontology (GO) - Molecular Function for WDR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with WDR27: view
genes like me logo Genes that share phenotypes with WDR27: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR27 Gene

Localization for WDR27 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR27 Gene COMPARTMENTS Subcellular localization image for WDR27 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for WDR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with WDR27: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDR27 Gene

Pathways & Interactions for WDR27 Gene

SuperPathways for WDR27 Gene

No Data Available

Interacting Proteins for WDR27 Gene

Gene Ontology (GO) - Biological Process for WDR27 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR27 Gene

Drugs & Compounds for WDR27 Gene

No Compound Related Data Available

Transcripts for WDR27 Gene

Unigene Clusters for WDR27 Gene

WD repeat domain 27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR27 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - - - - - - -
SP2: -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6:
SP7:
SP8: - - -
SP9: - - -
SP10:
SP11:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1:
SP2: -
SP3:
SP4:
SP5: - - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for WDR27 Gene

GeneLoc Exon Structure for
WDR27
ECgene alternative splicing isoforms for
WDR27

Expression for WDR27 Gene

mRNA expression in normal human tissues for WDR27 Gene

Protein differential expression in normal tissues from HIPED for WDR27 Gene

This gene is overexpressed in Nasal epithelium (37.9) and Liver (21.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR27 Gene



NURSA nuclear receptor signaling pathways regulating expression of WDR27 Gene:

WDR27

SOURCE GeneReport for Unigene cluster for WDR27 Gene:

Hs.131903
genes like me logo Genes that share expression patterns with WDR27: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for WDR27 Gene

Orthologs for WDR27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDR27 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR27 34
  • 71.3 (n)
  • 64.92 (a)
WDR27 35
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR27 34
  • 74.32 (n)
  • 68.67 (a)
WDR27 35
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr27 34
  • 71.92 (n)
  • 63.48 (a)
Wdr27 16
Wdr27 35
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR27 34
  • 98.63 (n)
  • 98.32 (a)
WDR27 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr27 34
  • 72.59 (n)
  • 64.98 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR27 35
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 54 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves WDR27 34
  • 61.14 (n)
  • 51.84 (a)
WDR27 35
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR27 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20428 34
wdr27 34
  • 58.47 (n)
  • 51.58 (a)
zebrafish
(Danio rerio)
Actinopterygii wdr27 34
  • 51.02 (n)
  • 43.88 (a)
wdr27 35
  • 35 (a)
OneToMany
wdr27 35
  • 54 (a)
OneToMany
Species where no ortholog for WDR27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR27 Gene

ENSEMBL:
Gene Tree for WDR27 (if available)
TreeFam:
Gene Tree for WDR27 (if available)

Paralogs for WDR27 Gene

(1) SIMAP similar genes for WDR27 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WDR27: view

No data available for Paralogs for WDR27 Gene

Variants for WDR27 Gene

Sequence variations from dbSNP and Humsavar for WDR27 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs4236176 - 169,670,627(+) CATCC(A/G)GGCTC intron-variant, nc-transcript-variant, reference, missense
rs35895089 - 169,659,138(-) CGCTA(C/G)TCAGG nc-transcript-variant, reference, missense
rs3800544 - 169,658,278(+) GACCA(C/G/T)GTCGC nc-transcript-variant, reference, missense
rs34313252 - 169,649,258(-) TTCAC(C/T)AAAGA nc-transcript-variant, reference, missense
rs9396946 - 169,632,990(+) CTTCC(A/G)CTATC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for WDR27 Gene

Variant ID Type Subtype PubMed ID
dgv3448n106 CNV deletion 24896259
dgv3449n106 CNV deletion 24896259
esv1172887 CNV deletion 17803354
esv1477213 CNV deletion 17803354
esv1936634 CNV deletion 18987734
esv1984752 CNV deletion 18987734
esv2033801 CNV deletion 18987734
esv21513 CNV loss 19812545
esv2560712 CNV deletion 19546169
esv2665981 CNV deletion 23128226
esv2668169 CNV deletion 23128226
esv2671793 CNV deletion 23128226
esv2674060 CNV deletion 23128226
esv2733507 CNV deletion 23290073
esv2733508 CNV deletion 23290073
esv2733509 CNV deletion 23290073
esv2733510 CNV deletion 23290073
esv2733511 CNV deletion 23290073
esv2733512 CNV deletion 23290073
esv2733513 CNV deletion 23290073
esv2733514 CNV deletion 23290073
esv2733515 CNV deletion 23290073
esv2733516 CNV deletion 23290073
esv2733518 CNV deletion 23290073
esv2733519 CNV deletion 23290073
esv2733520 CNV deletion 23290073
esv2762636 CNV loss 21179565
esv3381064 CNV duplication 20981092
esv3540942 CNV deletion 23714750
esv3540944 CNV deletion 23714750
esv3540946 CNV deletion 23714750
esv3611713 CNV loss 21293372
esv3611714 CNV loss 21293372
esv3611716 CNV loss 21293372
esv3611717 CNV loss 21293372
esv3611718 CNV loss 21293372
esv3611721 CNV loss 21293372
esv3611722 CNV loss 21293372
esv4341 CNV loss 18987735
esv5868 CNV loss 19470904
esv988735 CNV deletion 20482838
esv989386 CNV insertion 20482838
esv990511 CNV insertion 20482838
nsv1018818 CNV loss 25217958
nsv1031250 CNV loss 25217958
nsv1032232 CNV loss 25217958
nsv1074038 CNV deletion 25765185
nsv1074039 CNV deletion 25765185
nsv1074449 CNV deletion 25765185
nsv1074980 CNV deletion 25765185
nsv1078978 CNV insertion 25765185
nsv1121663 CNV deletion 24896259
nsv1129276 CNV insertion 24896259
nsv1140730 CNV deletion 24896259
nsv1150127 CNV deletion 26484159
nsv348441 CNV insertion 16902084
nsv348472 CNV insertion 16902084
nsv349459 CNV deletion 16902084
nsv349626 CNV deletion 16902084
nsv464223 CNV loss 19166990
nsv5600 CNV insertion 18451855
nsv605499 CNV gain 21841781
nsv605507 CNV loss 21841781
nsv830872 CNV loss 17160897
nsv949902 CNV deletion 24416366
nsv958368 CNV deletion 24416366

Variation tolerance for WDR27 Gene

Residual Variation Intolerance Score: 99.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.67; 96.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR27 Gene

Disorders for WDR27 Gene

Relevant External Links for WDR27

Genetic Association Database (GAD)
WDR27
Human Genome Epidemiology (HuGE) Navigator
WDR27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR27

No disorders were found for WDR27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR27 Gene

Publications for WDR27 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  3. Common genetic variation and the control of HIV-1 in humans. (PMID: 20041166) Fellay J. … Goldstein D.B. (PLoS Genet. 2009) 3 46 65
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 65
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 65

Products for WDR27 Gene

Sources for WDR27 Gene

Content