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Aliases for WDR27 Gene

Aliases for WDR27 Gene

  • WD Repeat Domain 27 2 3

External Ids for WDR27 Gene

Previous GeneCards Identifiers for WDR27 Gene

  • GC00U914116
  • GC06M169675
  • GC06M169857
  • GC06M167278
  • GC06M169457

Summaries for WDR27 Gene

Entrez Gene Summary for WDR27 Gene

  • This gene encodes a protein with multiple WD repeats. Proteins with these repeats may form scaffolds for protein-protein interaction and play key roles in cell signalling. Alternative splicing results in multiple transcript variants, but the full-length structure of some of these variants cannot be determined. [provided by RefSeq, Nov 2015]

GeneCards Summary for WDR27 Gene

WDR27 (WD Repeat Domain 27) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR27 Gene

Genomics for WDR27 Gene

Regulatory Elements for WDR27 Gene

Genomic Location for WDR27 Gene

169,426,407 bp from pter
169,702,063 bp from pter
275,657 bases
Minus strand

Genomic View for WDR27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR27 Gene

Proteins for WDR27 Gene

  • Protein details for WDR27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 27
    Protein Accession:
    Secondary Accessions:
    • A5PLM8
    • C9JGV0
    • Q5T066

    Protein attributes for WDR27 Gene

    827 amino acids
    Molecular mass:
    90038 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR27 Gene


neXtProt entry for WDR27 Gene

Proteomics data for WDR27 Gene at MOPED

Post-translational modifications for WDR27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR27 Gene

No data available for DME Specific Peptides for WDR27 Gene

Domains & Families for WDR27 Gene

Gene Families for WDR27 Gene

Suggested Antigen Peptide Sequences for WDR27 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 10 WD repeats.
  • Contains 10 WD repeats.
genes like me logo Genes that share domains with WDR27: view

Function for WDR27 Gene

Gene Ontology (GO) - Molecular Function for WDR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with WDR27: view
genes like me logo Genes that share phenotypes with WDR27: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR27

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR27 Gene

Localization for WDR27 Gene

Subcellular locations from

Jensen Localization Image for WDR27 Gene COMPARTMENTS Subcellular localization image for WDR27 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for WDR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with WDR27: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDR27 Gene

Pathways & Interactions for WDR27 Gene

SuperPathways for WDR27 Gene

No Data Available

Interacting Proteins for WDR27 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: A2RRH5-WDR27_HUMAN ENSP00000416289 for WDR27 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for WDR27 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR27 Gene

Drugs & Compounds for WDR27 Gene

No Compound Related Data Available

Transcripts for WDR27 Gene

Unigene Clusters for WDR27 Gene

WD repeat domain 27:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR27

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR27 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - - - - - - -
SP2: -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP8: - - -
SP9: - - -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
SP2: -
SP5: - - - -

Relevant External Links for WDR27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR27 Gene

mRNA expression in normal human tissues for WDR27 Gene

Protein differential expression in normal tissues from HIPED for WDR27 Gene

This gene is overexpressed in Nasal epithelium (37.9) and Liver (21.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WDR27 Gene

SOURCE GeneReport for Unigene cluster for WDR27 Gene Hs.131903

genes like me logo Genes that share expression patterns with WDR27: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for WDR27 Gene

Orthologs for WDR27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDR27 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR27 35
  • 71.3 (n)
  • 64.92 (a)
WDR27 36
  • 64 (a)
(Canis familiaris)
Mammalia WDR27 35
  • 74.32 (n)
  • 68.67 (a)
WDR27 36
  • 67 (a)
(Mus musculus)
Mammalia Wdr27 35
  • 71.92 (n)
  • 63.48 (a)
Wdr27 16
Wdr27 36
  • 61 (a)
(Pan troglodytes)
Mammalia WDR27 35
  • 98.63 (n)
  • 98.32 (a)
WDR27 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Wdr27 35
  • 72.59 (n)
  • 64.98 (a)
(Monodelphis domestica)
Mammalia WDR27 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
-- 36
  • 60 (a)
(Gallus gallus)
Aves WDR27 35
  • 61.14 (n)
  • 51.84 (a)
WDR27 36
  • 50 (a)
(Anolis carolinensis)
Reptilia WDR27 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20428 35
wdr27 35
  • 58.47 (n)
  • 51.58 (a)
(Danio rerio)
Actinopterygii wdr27 35
  • 51.02 (n)
  • 43.88 (a)
wdr27 36
  • 35 (a)
wdr27 36
  • 54 (a)
Species with no ortholog for WDR27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR27 Gene

Gene Tree for WDR27 (if available)
Gene Tree for WDR27 (if available)

Paralogs for WDR27 Gene

(1) SIMAP similar genes for WDR27 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WDR27: view

No data available for Paralogs for WDR27 Gene

Variants for WDR27 Gene

Sequence variations from dbSNP and Humsavar for WDR27 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3055 -- 169,666,416(+) ACTTA(C/T)CGCAT intron-variant
rs377552 -- 169,431,250(-) ACACA(C/T)ACAGA intron-variant
rs388404 -- 169,430,405(-) ACTCC(C/T)TCCTT intron-variant
rs407690 -- 169,426,436(-) GTTAA(G/T)AAGGG utr-variant-3-prime, nc-transcript-variant
rs408710 -- 169,429,081(-) AGGAG(A/C)GGGGC utr-variant-3-prime, intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR27 Gene

Variant ID Type Subtype PubMed ID
esv2733507 CNV Deletion 23290073
esv990511 CNV Insertion 20482838
nsv348472 CNV Insertion 16902084
nsv348441 CNV Insertion 16902084
nsv5600 CNV Insertion 18451855
esv2733508 CNV Deletion 23290073
esv988735 CNV Deletion 20482838
esv1172887 CNV Deletion 17803354
nsv887010 CNV Gain 21882294
nsv830872 CNV Loss 17160897
esv2674060 CNV Deletion 23128226
nsv464223 CNV Loss 19166990
nsv887011 CNV Loss 21882294
esv2560712 CNV Deletion 19546169
esv1984752 CNV Deletion 18987734
esv2733509 CNV Deletion 23290073
esv2668169 CNV Deletion 23128226
nsv349626 CNV Loss 16902084
esv1477213 CNV Deletion 17803354
esv1936634 CNV Deletion 18987734
esv2733510 CNV Deletion 23290073
esv5868 CNV Loss 19470904
nsv349459 CNV Loss 16902084
esv2033801 CNV Deletion 18987734
esv2733511 CNV Deletion 23290073
esv21513 CNV Loss 19812545
esv2733512 CNV Deletion 23290073
esv2665981 CNV Deletion 23128226
esv2733513 CNV Deletion 23290073
esv2733514 CNV Deletion 23290073
esv4341 CNV Deletion 18987735
esv2733515 CNV Deletion 23290073
esv2733516 CNV Deletion 23290073
esv989386 CNV Insertion 20482838
esv2671793 CNV Deletion 23128226
esv2733518 CNV Deletion 23290073
esv2733519 CNV Deletion 23290073
esv2733520 CNV Deletion 23290073

Variation tolerance for WDR27 Gene

Residual Variation Intolerance Score: 99.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.67; 96.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR27 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR27 Gene

Disorders for WDR27 Gene

Relevant External Links for WDR27

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with WDR27: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR27 Gene

Publications for WDR27 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67
  3. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. (PMID: 21980299) Bradfield J.P. … Hakonarson H. (PLoS Genet. 2011) 67
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 67

Products for WDR27 Gene

Sources for WDR27 Gene

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