Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDR27 Gene

Aliases for WDR27 Gene

  • WD Repeat Domain 27 2 3

External Ids for WDR27 Gene

Previous GeneCards Identifiers for WDR27 Gene

  • GC00U914116
  • GC06M169675
  • GC06M169857
  • GC06M167278

Summaries for WDR27 Gene

GeneCards Summary for WDR27 Gene

WDR27 (WD Repeat Domain 27) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR27 Gene

Genomics for WDR27 Gene

Regulatory Elements for WDR27 Gene

Genomic Location for WDR27 Gene

Start:
169,457,208 bp from pter
End:
169,702,063 bp from pter
Size:
244,856 bases
Orientation:
Minus strand

Genomic View for WDR27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR27 Gene

Proteins for WDR27 Gene

  • Protein details for WDR27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RRH5-WDR27_HUMAN
    Recommended name:
    WD repeat-containing protein 27
    Protein Accession:
    A2RRH5
    Secondary Accessions:
    • A5PLM8
    • C9JGV0
    • Q5T066

    Protein attributes for WDR27 Gene

    Size:
    827 amino acids
    Molecular mass:
    90038 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR27 Gene

Proteomics data for WDR27 Gene at MOPED

Post-translational modifications for WDR27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR27 Gene

No data available for DME Specific Peptides for WDR27 Gene

Domains for WDR27 Gene

Gene Families for WDR27 Gene

HGNC:
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for WDR27 Gene

Graphical View of Domain Structure for InterPro Entry

A2RRH5

UniProtKB/Swiss-Prot:

WDR27_HUMAN :
  • A2RRH5
Similarity:
  • Contains 10 WD repeats.
genes like me logo Genes that share domains with WDR27: view

Function for WDR27 Gene

Gene Ontology (GO) - Molecular Function for WDR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with WDR27: view

Phenotypes for WDR27 Gene

genes like me logo Genes that share phenotypes with WDR27: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR27

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for WDR27 Gene

Localization for WDR27 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR27 Gene COMPARTMENTS Subcellular localization image for WDR27 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for WDR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with WDR27: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDR27 Gene

Pathways for WDR27 Gene

SuperPathways for WDR27 Gene

No Data Available

Interacting Proteins for WDR27 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000416289%0d%0a9606.ENSP00000175506%0d%0a9606.ENSP00000367208%0d%0a
Selected Interacting proteins: ENSP00000416289 A2RRH5-WDR27_HUMAN for WDR27 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for WDR27 Gene

None

No data available for Pathways by source for WDR27 Gene

Transcripts for WDR27 Gene

Unigene Clusters for WDR27 Gene

WD repeat domain 27:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR27

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR27 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - - - - - - -
SP2: -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6:
SP7:
SP8: - - -
SP9: - - -
SP10:
SP11:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1:
SP2: -
SP3:
SP4:
SP5: - - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for WDR27 Gene

GeneLoc Exon Structure for
WDR27
ECgene alternative splicing isoforms for
WDR27

Expression for WDR27 Gene

mRNA expression in normal human tissues for WDR27 Gene

Protein differential expression in normal tissues for WDR27 Gene

This gene is overexpressed in Nasal epithelium (37.9) and Liver (21.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for WDR27 Gene

SOURCE GeneReport for Unigene cluster for WDR27 Gene Hs.131903

genes like me logo Genes that share expressions with WDR27: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for WDR27 Gene

Orthologs for WDR27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDR27 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR27 35
  • 71.3 (n)
  • 64.92 (a)
WDR27 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR27 35
  • 74.32 (n)
  • 68.67 (a)
WDR27 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr27 35
  • 71.92 (n)
  • 63.48 (a)
Wdr27 16
Wdr27 36
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR27 35
  • 98.63 (n)
  • 98.32 (a)
WDR27 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr27 35
  • 72.59 (n)
  • 64.98 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR27 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves WDR27 35
  • 61.14 (n)
  • 51.84 (a)
WDR27 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR27 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20428 35
wdr27 35
  • 58.47 (n)
  • 51.58 (a)
zebrafish
(Danio rerio)
Actinopterygii wdr27 35
  • 51.02 (n)
  • 43.88 (a)
wdr27 36
  • 35 (a)
OneToMany
wdr27 36
  • 54 (a)
OneToMany
Species with no ortholog for WDR27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR27 Gene

ENSEMBL:
Gene Tree for WDR27 (if available)
TreeFam:
Gene Tree for WDR27 (if available)

Paralogs for WDR27 Gene

Selected SIMAP similar genes for WDR27 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WDR27: view

No data available for Paralogs for WDR27 Gene

Variants for WDR27 Gene

Sequence variations from dbSNP and Humsavar for WDR27 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3055 -- 169,666,416(+) ACTTA(C/T)CGCAT intron-variant
rs725724 -- 169,593,309(-) GCCAC(G/T)TTTCG intron-variant
rs726792 -- 169,574,656(-) CCTCT(C/T)CATGA intron-variant
rs728565 -- 169,603,389(+) TTTTT(A/T)AATTT intron-variant
rs730002 -- 169,552,682(-) TCACA(A/G)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR27 Gene

Variant ID Type Subtype PubMed ID
esv2733507 CNV Deletion 23290073
esv990511 CNV Insertion 20482838
nsv348472 CNV Insertion 16902084
nsv348441 CNV Insertion 16902084
nsv5600 CNV Insertion 18451855
esv2733508 CNV Deletion 23290073
esv988735 CNV Deletion 20482838
esv1172887 CNV Deletion 17803354
nsv887010 CNV Gain 21882294
nsv830872 CNV Loss 17160897
esv2674060 CNV Deletion 23128226
nsv464223 CNV Loss 19166990
nsv887011 CNV Loss 21882294
esv2560712 CNV Deletion 19546169
esv1984752 CNV Deletion 18987734
esv2733509 CNV Deletion 23290073
esv2668169 CNV Deletion 23128226
nsv349626 CNV Loss 16902084
esv1477213 CNV Deletion 17803354
esv1936634 CNV Deletion 18987734
esv2733510 CNV Deletion 23290073
esv5868 CNV Loss 19470904
nsv349459 CNV Loss 16902084
esv2033801 CNV Deletion 18987734
esv2733511 CNV Deletion 23290073
esv21513 CNV Loss 19812545
esv2733512 CNV Deletion 23290073
esv2665981 CNV Deletion 23128226
esv2733513 CNV Deletion 23290073
esv2733514 CNV Deletion 23290073
esv4341 CNV Deletion 18987735
esv2733515 CNV Deletion 23290073
esv2733516 CNV Deletion 23290073
esv989386 CNV Insertion 20482838
esv2671793 CNV Deletion 23128226
esv2733518 CNV Deletion 23290073
esv2733519 CNV Deletion 23290073
esv2733520 CNV Deletion 23290073

Relevant External Links for WDR27 Gene

HapMap Linkage Disequilibrium report
WDR27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR27 Gene

Disorders for WDR27 Gene

Relevant External Links for WDR27

Genetic Association Database (GAD)
WDR27
Human Genome Epidemiology (HuGE) Navigator
WDR27

No disorders were found for WDR27 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for WDR27 Gene

Publications for WDR27 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  2. Common genetic variation and the control of HIV-1 in humans. (PMID: 20041166) Fellay J. … Goldstein D.B. (PLoS Genet. 2009) 3 48
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. WD40 proteins propel cellular networks. (PMID: 20451393) Stirnimann C.U. … MA1ller C.W. (Trends Biochem. Sci. 2010) 3
  5. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. (PMID: 21980299) Bradfield J.P. … Hakonarson H. (PLoS Genet. 2011) 3

Products for WDR27 Gene

Sources for WDR27 Gene

Back to Top

Content