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WDR27 Gene

protein-coding GIFtS: 41

GC06M169675

WD repeat domain 27
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC43690 ^¹, ²
OTTHUMP00000017676 ^²
OTTHUMP00000039063 ^²

Descriptions
WD repeat domain 27 ^²

External Ids
HGNC: 21248¹
Entrez Gene: 253769²
UniProtKB: A2RRH5³
Ensembl: ENSG00000184465⁷

Search outside databases for aliases for WDR27 gene

Previous GC identifer: GC00U914116

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the WDR27 gene

Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27

WDR27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M169675: (about GC identifiers)

Start:	169,599,232 bp from pter
End:	169,844,084 bp from pter
Size:	244,853 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_007302.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WDR27_HUMAN, A2RRH5 (See protein sequence)

Recommended Name: WD repeat-containing protein 27

Size: 827 amino acids; 90065 Da

Secondary accessions: A5PLM8 Q5T066

Alternative splicing: 3 isoforms: A2RRH5-1 A2RRH5-2 A2RRH5-3

REFSEQ proteins: NP_872358.3

ENSEMBL proteins:

ENSP00000383811 ENSP00000330265

Human Recombinant Proteins

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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (WDR27)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for WDR27:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for WDR27

Assays for WDR27:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry A2RRH5

ProtoNet protein and cluster: A2RRH5

UniProtKB/Swiss-Prot: WDR27_HUMAN, A2RRH5

Similarity: Contains 10 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR27)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_182552

Applied Biosystems Silencer® siRNAs for WDR27

Sigma-Aldrich siRNA for WDR27

Sigma-Aldrich shRNA for WDR27

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_182552
Myc/DDK tagged cDNA clone in CMV expression vector: NM_182552
untagged cDNA clone in CMV expression vector: NM_182552

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_182552

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR27

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR27)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_182552

Sigma-Aldrich siRNA for WDR27

Sigma-Aldrich shRNA for WDR27

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_182552

REFSEQ mRNAs for WDR27 gene:

NM_182552.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_182552

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_182552
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_182552
                                 untagged cDNA clone in CMV expression vector: NM_182552

Additional cDNA sequence:

AK128656.1 AK131435.1 AK293148.1 BC035289.1 BC040606.1 BC073148.1 BC131633.1 BC142982.1

BX648854.1

20 DOTS entries:

DT.100008587 DT.111152 DT.95295353 DT.422763 DT.438920 DT.100641697 DT.309527 DT.409070

DT.441796 DT.92062632 DT.97815815 DT.102827763 DT.102827768 DT.121403674 DT.92030489 DT.40124565

DT.86841469 DT.87046654 DT.91854374 DT.40208238

24/140 AceView cDNA sequences (see all 140 ):

CA414712 AI917741 AW963606 AW015631 AA479979 BQ447208 AI637948 AI300988

BF061565 BC073148 H80337 AI207993 AW778877 AI867917 AW300877 CD557568

AA315265 NM_182552 AI743363 AI990380 AA835653 AA824637 AA450086 AA478759

highest scoring ESTs for WDR27:

AA621885 AA934986 AI207993 AI797860 AW137483 BC040606 BF998082 BI464479 AA211711 AA315265

Unigene Cluster for WDR27:

WD repeat domain 27

Hs.709476 [show with all ESTs]

Unigene Representative Sequence: AK131435

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for WDR27 (see all 11 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b	^	10	^	11a	·	11b	·	11c	^	12	^	13	^	14a	·	14b	·	14c	^	15	^	16	^	17a	·	17b	^	18	^
SP1:																	-				-		-		-		-										-		-										-
SP2:																																																	-
SP3:																	-										-						-				-		-
SP4:																											-						-				-		-						-
SP5:																																																	-		-

ExUns:	19	^	20	^	21	^	22	^	23	^	24	^	25	^	26	^	27	^	28
SP1:
SP2:													-
SP3:
SP4:
SP5:	-		-		-		-

About this scheme

ECgene alternative splicing isoforms for WDR27

2 Ensembl transcripts including schematic representations:

ENST00000401031 ENST00000333572

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR27 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for WDR27

¹ / ² / ³

14 probe-sets matching WDR27 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
56784_at²^{, 3}	U95-C	1	1.00	1.00	0.85	1.12	AI016894	0.60	1.00	0.82	1
45648_at²^{, 3}	U95-B	1	1.00	1.00	0.75	0.94	AI279101	0.60	1.00	0.82	1
85318_at²^{, 3}	U95-E	1	1.00	1.00	-0.24	1.07	AI797860	0.80	1.00	0.91	1
59262_at²^{, 3}	U95-B	1	1.00	1.00	0.71	0.89	AA810882	0.60	1.00	0.82	1
56785_at²^{, 3}	U95-C	1	0.94	1.00	0.73	0.97	AA743397	0.60	1.00	0.82	1
81099_s_at²^{, 3}	U95-E	1	0.38	1.00	0.85	1.02	AI091785	0.60	1.00	0.82	1
235298_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW194823	0.60	1.00	0.82	1
228326_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI016894	0.60	1.00	0.82	1
235576_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW474542	0.40	1.00	0.76	1
238074_at²^{, 3}	U133-B	1	0.82	1.00	--	--	AW961197	0.60	1.00	0.82	1
235298_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228326_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
235576_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
238074_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

GeneDecks WDR27 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACGTTATATC

SOURCE GeneReport for Unigene cluster: Hs.709476

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WDR27 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WDR27¹	--	WD repeat domain 27	73.26(n) 67.77(a)	612528 XM_850257.1 XP_855350.1
cow (Bos taurus)	WDR27¹	--	similar to WD repeat domain 27	71.47(n) 65.53(a)	788957 XM_001255858.1 XP_001255859.1
rat (Rattus norvegicus)	Wdr27¹	--	WD repeat domain 27	71.94(n) 63.83(a)	308222 XM_218008.4 XP_218008.4
mouse (Mus musculus)	Wdr27^{1, 5}	17⁵	WD repeat domain 27^{1, 5}	71.92(n)¹ 63.48(a)¹	71682¹ NM_175173.3¹ NP_780382.2¹ AK002615⁵ AK040117⁵ (see all 9)
zebrafish (Danio rerio)	zgc:123251¹	--	zgc:123251	47.85(n) 38.73(a)	641503 NM_001037440.1 NP_001032517.1

About this table Species with no ortholog for WDR27

ENSEMBL Gene Tree for WDR27

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1417 NCBI SNPs in WDR27 are shown (see all 1417 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 431)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4236176^1,2	A,C,F,H	169812648(+)	`CATCCG/AGGCTC`	1	P/L	mis¹		14	EU EA WA NA	1438
	rs7758376^1,2	A,C,F,H	169598892(+)	`ACAGGG/CAGAGG`	1	--	ng5¹		4	EU EA WA	416
	rs1047910^1,2	A,C,F,H	169599376(-)	`AATGGC/TGTCCA`	1	--	ut3¹		5	MN EU EA WA	602
	rs1535474^1,2	A,C,F,H	169599128(-)	`GTGAGT/GGTGGC`	1	--	ng5¹		4	EU EA WA	418
	rs9396946^1,2	C,F,H	169775011(+)	`CTTCCG/ACTATC`	1	V/A	mis¹ ese³		9	EU EA WA NA	918
	rs3800544^1,2	C,F,H	169800299(+)	`GACCAC/TGTCGC`	1	R/H	mis¹ ese³		9	EA EU WA	1776
	rs34313252^1,2	C,F	169791279(-)	`TTCACC/TAAAGA`	1	P/L	mis¹		5	NA EU EA WA	488
	rs35895089^1,2	C,F	169801159(-)	`CGCTAG/CTCAGG`	1	L/V	mis¹		5	NA EU EA WA	490
	rs7744717^1,2	C,H	169791275(+)	`TTGGTC/GTTTGG`	1	K/N	mis¹ ese³		5	EU EA WA NA	426
	rs9478086^1,2	A,C,F,H	169793974(+)	`CCAGAT/CGACCT`	1	S/S	syn¹		9	EU EA WA NA	910

About this table

HapMap Linkage Disequilibrium images for WDR27 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for WDR27 gene:

Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)⁴ Mungall A.J.... Beck S. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 253769	HGNC: 21248	AceView: MGC43690	Ensembl:ENSG00000184465	euGenes: HUgn253769
ECgene: WDR27	H-InvDB: WDR27

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for WDR27
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for WDR27:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for WDR27-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for WDR27		Browse antibodies at Sigma-Aldrich
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	Lentivirus-delivered shRNAs for WDR27		Browse small molecules at Sigma-Aldrich
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for WDR27

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WDR27 Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for WDR27

Summaries
for WDR27

Genomic Location
for WDR27

Proteins
for WDR27

Protein Domains/
Families
for WDR27

Gene Function
for WDR27

Pathways & Interactions
for WDR27

Drugs & Compounds
for WDR27

Transcripts
for WDR27

Expression
for WDR27

Orthologs
for WDR27

Paralogs
for WDR27

SNPs/Variants
for WDR27

Disorders & Mutations
for WDR27

Medical News
for WDR27

Publications
for WDR27

Search for WDR27

Genome Databases showing WDR27

Other Databases showing WDR27

Specialized Databases showing WDR27

Licensable Technologies
for WDR27

Services
for WDR27

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WDR27 Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor WDR27

Summariesfor WDR27

Genomic Locationfor WDR27

Proteinsfor WDR27

Protein Domains/Familiesfor WDR27

Gene Functionfor WDR27

Pathways & Interactionsfor WDR27

Drugs & Compoundsfor WDR27

Transcriptsfor WDR27

Expression for WDR27

Orthologsfor WDR27

Paralogsfor WDR27

SNPs/Variantsfor WDR27

Disorders & Mutationsfor WDR27

Medical Newsfor WDR27

Publicationsfor WDR27

Search for WDR27

Genome Databases showing WDR27

Other Databases showing WDR27

Specialized Databases showing WDR27

Licensable Technologiesfor WDR27

Servicesfor WDR27

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for WDR27

Summaries
for WDR27

Genomic Location
for WDR27

Proteins
for WDR27

Protein Domains/
Families
for WDR27

Gene Function
for WDR27

Pathways & Interactions
for WDR27

Drugs & Compounds
for WDR27

Transcripts
for WDR27

Expression
for WDR27

Orthologs
for WDR27

Paralogs
for WDR27

SNPs/Variants
for WDR27

Disorders & Mutations
for WDR27

Medical News
for WDR27

Publications
for WDR27

Licensable Technologies
for WDR27

Services
for WDR27