WDR27 Gene
protein-coding GIFtS: 41
GCID: GC06M169857
|
|
WD repeat domain 27
| |
Aliases
for WDR27 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 271 2 | | MGC436901 | | WD Repeat-Containing Protein 272 |
Export aliases for WDR27 gene to outside databasesPrevious GC identifers: GC00U914116 GC06M169675 GC06M167278 |
Summaries
for WDR27 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for WDR27 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR27 gene promoter:
Nkx3-1 Nkx3-1 v4 Nkx3-1 v1 STAT5A E4BP4 AREB6 Nkx3-1 v2 POU2F1 POU2F1a Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR27
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR27 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27WDR27 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M169857: view genomic region
(about GC identifiers)
Start:
|
169,857,307 bp from pter |
End:
|
170,102,159 bp from pter |
Size:
|
244,853 bases |
Orientation:
|
minus strand |
|
Proteins
for WDR27 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR27_HUMAN, A2RRH5 (See
protein sequence)Recommended Name: WD repeat-containing protein 27 Size: 827 amino acids; 90038 Da
Secondary accessions: A5PLM8 Q5T066Alternative splicing: 4 isoforms: A2RRH5-1 A2RRH5-2 A2RRH5-3 A2RRH5-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for WDR27: NX_A2RRH5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A2RRH5
WDR27 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001189479.1 NP_872358.4
ENSEMBL proteins: ENSP00000416289 ENSP00000411915 ENSP00000449696 ENSP00000330265 ENSP00000397869 ENSP00000406114
Human Recombinant Protein Products:
WDR27 Antibody Products:
Assay Products for WDR27: |
Protein
Domains /
Families
for WDR27 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR27 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A2RRH5ProtoNet protein and cluster: A2RRH5 UniProtKB/Swiss-Prot: WDR27_HUMAN, A2RRH5Similarity: Contains 10 WD repeats |
Function
for WDR27 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR27 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR27
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): WDR27 (NM_182552) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR27 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR27 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR27 |
1 GenomeRNAi human phenotype for WDR27:
|
Pathways & Interactions
for WDR27 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR27
|
Drugs & Compounds
for WDR27 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR27
Search CenterWatch for drugs/clinical trials and news about WDR27
|
Transcripts
for WDR27 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR27 gene (2 alternative transcripts): NM_001202550.1 NM_182552.4 Unigene Cluster for WDR27: WD repeat domain 27 Hs.131903 [show with all ESTs]Unigene Representative Sequence: NM_18255214 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000479310 ENST00000448612(uc021zio.1) ENST00000546525 ENST00000441385
ENST00000467418(uc003qwz.1) ENST00000486490 ENST00000476322 ENST00000496752
ENST00000464249 ENST00000546953(uc010kkx.3) ENST00000474018 ENST00000333572(uc003qwx.3)
ENST00000423258(uc003qwv.2 uc003qwy.3) ENST00000420344(uc011egw.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR27 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR27
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): WDR27 (NM_182552) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR27 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR27 |
Additional cDNA sequence: BC035289.1 BC040606.1 BC131633.1 BX648854.1 19 DOTS entries: DT.100008587 DT.111152 DT.422763 DT.100641697 DT.438920 DT.309527 DT.441796 DT.92062632 DT.95295353 DT.409070 DT.102827768 DT.97815815 DT.92030489 DT.102827763 DT.121403674 DT.86841469 DT.87046654 DT.40208238 DT.91854374 24/140 AceView cDNA sequences (see all 140): AA824637 AI743363 AA315265 BF061565 AA450086 AW963606 AA835653 AI990380 AW300877 AA479979 AI867917 BC073148 H80337 AW015631 NM_182552 AI300988 AI637948 CA414712 AI207993 BQ447208 CD557568 AI917741 AW778877 AI291472
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for WDR27 (see all 11) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | - | | - | | | | | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | |
| ExUns: | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | |
| SP5: | - | | - | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for WDR27
|
Expression
for WDR27 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR27 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTATTACA
About this image
See WDR27 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR27
SOURCE GeneReport for Unigene cluster: Hs.131903
SABiosciences Custom PCR Arrays for WDR27
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR27
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR27 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR27 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR27 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR27 |
Orthologs
for WDR27 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for WDR27 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for WDR27 (if available)
TreeFam Gene Tree for WDR27 (if available) |
Paralogs
for WDR27 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for WDR27 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR27 (169857307 - 170102159 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for WDR27
3 CNVs: 94258 99816 81775
11 Indels: 94257 47064 62602 12890 47065 81774 12889 42583 28198 69695 47063 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR27 |
|
Disorders
/ Diseases
for WDR27 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 WDR27 for disorders About MalaCards
WDR27 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: WDR27 (4 documents)
Export disorders for WDR27 gene to outside databases
|
Publications
for WDR27 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR27 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with WDR27) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A genome-wide meta-analysis of six type 1 diabetes coh orts identifies multiple associated loci. (PubMed id 21980299)1 Bradfield J.P....Hakonarson H. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- WD40 proteins propel cellular networks. (PubMed id 20451393)1 Stirnimann C.U....MA1ller C.W. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Common genetic variation and the control of HIV-1 in humans. (PubMed id 20041166)1 Fellay J....Goldstein D.B. (2009)
- Diversity of WD-repeat proteins. (PubMed id 18925368)1 Smith T.F. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
|
External Searches for WDR27 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR27 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR27 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR27 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR27 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR27 gene:
Search GeneIP for patents involving WDR27
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR27 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WDR27 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDR27 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR27 | | | OriGene Protein Over-expression Lysate for WDR27 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WDR27 | | OriGene 3'-UTR Clone for WDR27 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR27 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR27 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for WDR27 | | OriGene Custom Protein Services for WDR27 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR27 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR27 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR27 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR27 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR27 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR27 |
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 | | | WDR27 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR27 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR27 |
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