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WDR26 Gene

protein-coding   GIFtS: 47

GC01M222641
WD repeat domain 26
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CDW2 2, 3
FLJ21016 1, 2
MIP2 2, 3
OTTHUMP00000035756 2
Descriptions
CUL4- and DDB1-associated WDR protein 2 3
Myocardial ischemic preconditioning up-regulated protein 2 3
WD repeat domain 26 2
myocardial ischemic preconditioning upregulated protein 2 2
External Ids
HGNC: 212081
Entrez Gene: 802322
UniProtKB: Q9H7D73
Ensembl: ENSG000001629237
Search outside databases for aliases for WDR26 gene

Previous GC identifers: GC01M220982 GC01M221550 GC01M221549 GC01M220881

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for WDR26:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved
regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which
may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are
involved in a variety of cellular processes, including cell cycle progression, signal
transduction, apoptosis, and gene regulation. Two transcript variants encoding two different
isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7
Function: May be involved in MAPK pathways

Gene Wiki entry for WDR26

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WDR26 gene  

Entrez Gene cytogenetic band: 1q42.11   Ensembl cytogenetic band:  1q42.11   HGNC cytogenetic band: 1q42.13

WDR26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M222641:     (about GC identifiers)

Start:
222,639,728 bp from pter
End:
222,688,624 bp from pter
Size:
48,897 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004559.13  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7 (See protein sequence)
Recommended Name: WD repeat-containing protein 26  
Size: 661 amino acids; 72124 Da
Subunit: Interacts with DDB1-CUL4A/B E3 ligase complexes
Subcellular location: Cytoplasm
Sequence caution: Sequence=BAB14955.1; Type=Erroneous termination; Positions=274; Note=Translated
as Lys;
Secondary accessions: A0MNN3 Q4G100 Q59EC4 Q5GLZ9 Q86UY4 Q9H3C2
Alternative splicing: 4 isoforms:  Q9H7D7-1   Q9H7D7-2   Q9H7D7-3   Q9H7D7-4   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001108585.1  NP_079436.3  


    ENSEMBL proteins: 
    ENSP00000295024 ENSP00000355817 


    Human Recombinant Proteins 
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    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IDA15378603
    About this table

    Antibodies for WDR26: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for WDR26

    Assays for WDR26: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/8 InterPro domains/families (see all 8 ):
     IPR019782 WD40_repeat_2
     IPR019775 WD40_repeat_CS
     IPR006594 LisH_dimerisation
     IPR019781 WD40_repeat_sg
     IPR006595 CTLH_C


       GeneDecks  WDR26 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9H7D7

    ProtoNet protein and cluster: Q9H7D7

    1 Blocks protein family: IPB006595 CTLH

    UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7
    Similarity: Contains 1 CTLH domain
    Similarity: Contains 1 LisH domain
    Similarity: Contains 6 WD repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WDR26)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_025160

                  Applied Biosystems Silencer® siRNAs for WDR26

                  Sigma-Aldrich siRNA for WDR26  
                         Sigma-Aldrich shRNA for WDR26  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001115113
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001115113
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001115113 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_025160

    UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7
    Function: May be involved in MAPK pathways

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for WDR26

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WDR26)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_025160

                  Sigma-Aldrich siRNA for WDR26  
                         Sigma-Aldrich shRNA for WDR26  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001115113  NM_025160  

    REFSEQ mRNAs for WDR26 gene (2 alternative transcripts): 

    NM_001115113.1   NM_025160.5   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001115113  NM_025160  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001115113
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001115113
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001115113 

    Additional cDNA sequence: 

    AB209887.1 AF130049.1 AK023023.1 AK024669.1 AK027236.1 AK225061.1 AK299230.1 AK307909.1 
    AY221751.1 AY304473.1 BC031471.2 BC034498.1 BC041978.1 BC052301.1 BC063817.1 CR593691.1 
    EF011612.1 

    24/34 DOTS entries (see all 34 ):

    DT.100795905  DT.101975173  DT.95163085  DT.100795906  DT.100760675  DT.95102495  DT.40276008  DT.91777951 
    DT.121397955  DT.91912814  DT.121397840  DT.213921  DT.95150875  DT.97870627  DT.100653769  DT.100894033 
    DT.91967839  DT.95255524  DT.100893949  DT.100893975  DT.100894282  DT.100894389  DT.100894582  DT.100894636 

    24/395 AceView cDNA sequences (see all 395 ):

    BF430930 AI493064 BM917729 BX111312 Z46059 AA134581 BQ072818 AI470408 
    AW088212 BG572627 BX496766 BQ018556 AW955764 BF732400 AI767639 AI333095 
    AI634544 AI467858 BX506802 AA724426 BE676146 AA291922 BE464371 BE645106 

    highest scoring ESTs for WDR26:

    AA210688 AA633397 AA983250 AL042592 AY304473 BC034498 BC052301 BF509638 BF513485 BG718836 

    Unigene Cluster for WDR26:

    WD repeat domain 26
    Hs.497873  [show with all ESTs]
    Unigene Representative Sequence: AY221751


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for WDR26 (see all 6 )

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
    SP1:                                      -                                                                                               -                     
    SP2:                                      -     -                                   -                 -                                   -                     
    SP3:                                            -                                   -                 -                                   -                     
    SP4:              -     -                       -                                                                                                               
    SP5:                          -                                                                                                                                 

    About this scheme

    ECgene alternative splicing isoforms for WDR26

    2 Ensembl transcripts including schematic representations:
    ENST00000295024  ENST00000366852  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    WDR26 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for WDR26

    1 / 2 / 3

    12 probe-sets matching WDR26 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    55600_at2, 3 U95-B 1 1.00 1.00 0.95 1.10 N30002 0.80 1.00 0.91 1
    53117_at2, 3 U95-B 1 1.00 1.00 0.82 0.92 AL042428 0.60 1.00 0.82 1

    50071_at2, 3 U95-B 1 1.00 1.00 0.86 0.96 AL042592 0.80 1.00 0.91 1

    45520_at2, 3 U95-B 1 1.00 1.00 0.95 1.03 AA983250 0.80 1.00 0.91 1

    224897_at2, 3 U133-B 1 1.00 1.00 -- -- BF510490 0.60 1.00 0.82 1

    224905_at2, 3 U133-B 1 1.00 1.00 -- -- AA482548 0.60 1.00 0.82 1

    224898_at2, 3 U133-B 1 1.00 1.00 -- -- BG177759 0.60 1.00 0.82 1

    218107_at2, 3 U133-A 1 1.00 1.00 -- -- NM_025160 0.60 1.00 0.82 1

    224897_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    224905_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    224898_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    218107_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  WDR26 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.497873

    UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7
    Tissue specificity: Broadly expressed, with highest levels in heart and skeletal muscle

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for WDR26 gene from 5/16 species (see all 16 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    WDR261   -- WD repeat domain 26 95.05(n)
    100(a)
    480115  XM_537237.2  XP_537237.2 
    cow
    (Bos taurus)
    WDR261   -- WD repeat domain 26 97.08(n)
    99.81(a)
    767999  NM_001077059.1  NP_001070527.1 
    rat
    (Rattus norvegicus)
    Wdr261   -- WD repeat domain 26 92.47(n)
    99.16(a)
    498301  XM_573529.2  XP_573529.1 
    mouse
    (Mus musculus)
    Wdr261, 5 15
    WD repeat domain 261, 5 93.26(n)1
    99.61(a)1
    2267571  NM_145514.31  NP_663489.31 
     AA6932415  AA7952845  (see all 37)
    chicken
    (Gallus gallus)
    WDR261   -- WD repeat domain 26 90.66(n)
    96.5(a)
    421324  XM_419389.2  XP_419389.2 
    About this table        Species with no ortholog for WDR26

    ENSEMBL Gene Tree for WDR26
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for WDR26 gene
    FBXW52  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/263 NCBI SNPs in WDR26 are shown (see all 263 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 95)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs127456101,2
    A,C,F,H222640224(+) ACTTTC/TAGTAA 2 -- ut31 ese37Minor allele frequency- T:0.25NA EU EA WA 556
    rs46535861,2
    A,C,F,H222641996(+) GCACCA/GTAGCA 2 -- ut3114Minor allele frequency- G:0.15NS NA EU EA WA 844
    rs168479451,2
    C,F,H222644020(+) CCCCAA/GTCGGG 2 -- ut3112Minor allele frequency- G:0.10NA EA EU WA 1042
    rs175039381,2
    C,F,H222641641(+) GGCTTC/TTTTAC 2 -- ut317Minor allele frequency- T:0.14NA EU EA WA 562
    rs104952201,2
    C,F,H222641595(-) TTTCTG/CATCCA 2 -- ut31 ese312Minor allele frequency- C:0.11NS EU EA WA NA 662
    rs118097101,2
    C,F,H222642497(+) TACCCC/AACAAT 2 -- ut314Minor allele frequency- A:0.11EU EA WA 414
    rs109166081,2
    C,F,H222642566(+) ATCATA/TATTAT 2 -- ut317Minor allele frequency- T:0.03EU EA WA NA 544
    rs37956371,2
    F,H222643707(-) GAATTT/GCCTTC 2 -- ut31 trp34Minor allele frequency- G:0.01EU EA WA 416
    rs66964071,2
    H222643251(+) GGGTAC/TTGATG 2 -- ut31 ese34Minor allele frequency- T:0.00EU EA WA 420
    rs168479041,2
    H222640427(+) AACAAT/CAGCTT 2 -- ut317Minor allele frequency- C:0.00NA EU EA WA 560
    About this table

    HapMap Linkage Disequilibrium images for WDR26 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/14 PubMed articles for WDR26 gene (see all 14 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 80232 HGNC: 21208 AceView: WDR26 Ensembl:ENSG00000162923 euGenes: HUgn80232
    ECgene: WDR26 H-InvDB: WDR26
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for WDR26:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for WDR26 Browse antibodies at Sigma-Aldrich
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     Lentivirus-delivered shRNAs for WDR26 Browse small molecules at Sigma-Aldrich
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