WDR26 Gene
protein-coding GIFtS: 51
GCID: GC01M224573
|
|
WD repeat domain 26
| |
Aliases for WDR26 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| WD Repeat Domain 261 2 | | FLJ210161 | | GID71 2 | | GID Complex Subunit 7 Homolog2 | | Myocardial Ischemic Preconditioning Up-Regulated Protein 22 3 | | Myocardial Ischemic Preconditioning Upregulated Protein 22 | | CDW22 3 | | WD Repeat-Containing Protein 262 | | MIP22 3 | | EC 1.4.4.28 | | CUL4- And DDB1-Associated WDR Protein 22 3 | | EC 2.7.7.88 |
Export aliases for WDR26 gene to outside databasesPrevious GC identifers: GC01M220982 GC01M221550 GC01M221549 GC01M220881 GC01M222641 GC01M195092 |
Summaries for WDR26 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for WDR26: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric ormultiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycleprogression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two differentisoforms have been found for this gene. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7Function: May be involved in MAPK pathways Gene Wiki entry for WDR26
|
Genomic Views for WDR26 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the WDR26 gene promoter: NF-YB Elk-1 CBF-B CBF-A Pax-5 NF-YA Olf-1 CP1A NF-Y CBF(2) Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR26
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR26 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q42.13 Ensembl cytogenetic band: 1q42.12 HGNC cytogenetic band: 1q42.13WDR26 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M224573: view genomic region
(about GC identifiers)
Start:
|
224,572,845 bp from pter |
End:
|
224,624,735 bp from pter |
Size:
|
51,891 bases |
Orientation:
|
minus strand |
|
Proteins for WDR26 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7 (See
protein sequence)Recommended Name: WD repeat-containing protein 26 Size: 661 amino acids; 72124 Da
Subunit: Interacts with DDB1-CUL4A/B E3 ligase complexes
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAG35477.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAH52301.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH63817.2;Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAO67709.1; Type=Erroneous initiation;Note=Translation N-terminally extended; Sequence=AAQ74770.1; Type=Erroneous initiation; Note=Translation N-terminallyextended; Sequence=ABK41102.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14955.1;Type=Erroneous termination; Positions=274; Note=Translated as Lys; Sequence=BAD93124.1; Type=Erroneous initiation;Note=Translation N-terminally shortened;
Secondary accessions: A0MNN3 Q4G100 Q59EC4 Q5GLZ9 Q86UY4 Q9H3C2Alternative splicing: 4 isoforms: Q9H7D7-1 Q9H7D7-2 Q9H7D7-3 Q9H7D7-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for WDR26: NX_Q9H7D7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H7D7 2 DME Specific Peptides for WDR26 (Q9H7D7)
WDR26 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001108585.2 NP_079436.4 ENSEMBL proteins: ENSP00000408108 ENSP00000424784 ENSP00000422758 ENSP00000403597 ENSP00000295024 ENSP00000355817 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
WDR26 for ontologies About GeneDecksing
WDR26 Antibody Products: Assay Products for WDR26: |
Protein
Domains / Families for WDR26 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR26 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H7D7ProtoNet protein and cluster: Q9H7D7 1 Blocks protein family: IPB006595 CTLH
UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7Similarity: Contains 1 CTLH domainSimilarity: Contains 1 LisH domainSimilarity: Contains 6 WD repeats |
Function for WDR26 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7Function: May be involved in MAPK pathwaysEnzyme Numbers (IUBMB): EC 1.4.4.22 EC 2.7.7.82
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR26 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR26 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR26 |
1 GenomeRNAi human phenotype for WDR26:
|
Pathways & Interactions for WDR26 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR26
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
 5/33 Interacting proteins for WDR26 (Q9H7D72, 3 ENSP000002950244) via UniProtKB, MINT, STRING, and/or I2D (see all 33)About this table
|
Drugs & Compounds for WDR26 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for WDR26 Search CenterWatch for drugs/clinical trials and news about WDR26 
|
Transcripts for WDR26 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for WDR26 gene (2 alternative transcripts): NM_001115113.2 NM_025160.6 Unigene Cluster for WDR26: WD repeat domain 26 Hs.497873 [show with all ESTs]Unigene Representative Sequence: NM_02516011 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000414423(uc001hoq.4 uc001hop.4 uc021pjp.1) ENST00000480676 ENST00000486652 ENST00000479727 ENST00000443112(uc009xei.2) ENST00000489825 ENST00000477425 ENST00000445239 ENST00000479778(uc021pjt.1) ENST00000295024 ENST00000366852
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR26 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR26 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): WDR26 (NM_001115113) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR26 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR26  |
Additional cDNA sequence: AB209887.1 AB586698.1 AK023023.1 AK024669.1 AK027236.1 AK225061.1 AK299230.1 AK307909.1 AY221751.1 AY304473.1 BC031471.2 BC034498.1 BC041978.1 BC052301.1 BC063817.1 EF011612.1 15 DOTS entries: DT.100795905 DT.101975173 DT.95163085 DT.100795906 DT.100760675 DT.95102495 DT.91777951 DT.91912814 DT.121397840 DT.121397955 DT.213921 DT.97870627 DT.100653769 DT.95150875 DT.95255524 24/395 AceView cDNA sequences (see all 395): AW088212 BQ924537 BQ072818 BE503191 BQ018556 BQ716233 BF971220 BF430930 BM966979 BQ929425 BE463592 BM975220 AW955764 BE504952 AI284386 BQ436591 CA944741 AW467998 BF439186 CR593691 BC031471 BI917529 AI445820 BM698826 GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for WDR26 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | |
| SP1: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for WDR26
|
Expression for WDR26 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR26 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TCAGTGCGCA
About this image See WDR26 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for WDR26
SOURCE GeneReport for Unigene cluster: Hs.497873 UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7Tissue specificity: Broadly expressed, with highest levels in heart and skeletal muscle SABiosciences Custom PCR Arrays for WDR26
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR26 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR26 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR26 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR26 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR26 |
Orthologs for WDR26 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WDR26 gene from 9/32 species (see all 32) About this table
ENSEMBL Gene Tree for WDR26 (if available) TreeFam Gene Tree for WDR26 (if available)  |
Paralogs for WDR26 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for WDR26 gene
- FBXW52
2 SIMAP similar genes for WDR26 using alignment to 5 protein entries: WDR26_HUMAN (see all proteins):POC1B CORO1C
WDR26 for paralogs About GeneDecksing
|
Genomic Variants for WDR26 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 1 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR26 (224572845 - 224624735 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for WDR26 2 CNVs: 31690 5554  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR26 |
|
Disorders
/ Diseases for WDR26 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDR26 for disorders About GeneDecksing
5 diseases for WDR26: About MalaCardsklebsiella ischemia hypoxia hepatitis malaria Export disorders for WDR26 gene to outside databases
|
Publications for WDR26 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR26 gene, integrated from 9 sources (see all 41): (articles sorted by number of sources associating them with WDR26) | |  | Utopia: connect your pdf to the dynamic world of online information |
- CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PubMed id 17041588)1, 2 Higa L.A.... Zhang H. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- WDR26: a novel Gbeta-like protein, suppresses MAPK signaling pathway. (PubMed id 15378603)1, 2 Zhu Y.... Liu M. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- The WD40 repeat protein WDR26 binds Gbg and promotes G bg-dependent signal transduction and leukocyte migration. (PubMed id 22065575)1 Sun Z....Chen S. (2011)
|
External Searches for WDR26 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing WDR26 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR26 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR26 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for WDR26 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR26 gene: Search GeneIP for patents involving WDR26
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for WDR26 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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 | |
 |
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