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Aliases for WDR26 Gene

Aliases for WDR26 Gene

  • WD Repeat Domain 26 2 3
  • Myocardial Ischemic Preconditioning Up-Regulated Protein 2 3 4
  • CUL4- And DDB1-Associated WDR Protein 2 3 4
  • CDW2 3 4
  • MIP2 3 4
  • Myocardial Ischemic Preconditioning Upregulated Protein 2 3
  • GID Complex Subunit 7 Homolog (S. Cerevisiae) 2
  • GID Complex Subunit 7 Homolog 3
  • EC 1.4.4.2 63
  • EC 2.7.7.8 63
  • GID7 3

External Ids for WDR26 Gene

Previous GeneCards Identifiers for WDR26 Gene

  • GC01M220982
  • GC01M221550
  • GC01M221549
  • GC01M220881
  • GC01M222641
  • GC01M224573
  • GC01M195092

Summaries for WDR26 Gene

Entrez Gene Summary for WDR26 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR26 Gene

WDR26 (WD Repeat Domain 26) is a Protein Coding gene. Diseases associated with WDR26 include klebsiella infection.

UniProtKB/Swiss-Prot for WDR26 Gene

  • May be involved in MAPK pathways.

Gene Wiki entry for WDR26 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR26 Gene

Genomics for WDR26 Gene

Regulatory Elements for WDR26 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WDR26 Gene

Chromosome:
1
Start:
224,385,143 bp from pter
End:
224,437,033 bp from pter
Size:
51,891 bases
Orientation:
Minus strand

Genomic View for WDR26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR26 Gene

Proteins for WDR26 Gene

  • Protein details for WDR26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7D7-WDR26_HUMAN
    Recommended name:
    WD repeat-containing protein 26
    Protein Accession:
    Q9H7D7
    Secondary Accessions:
    • A0MNN3
    • Q4G100
    • Q59EC4
    • Q5GLZ9
    • Q86UY4
    • Q9H3C2

    Protein attributes for WDR26 Gene

    Size:
    661 amino acids
    Molecular mass:
    72124 Da
    Quaternary structure:
    • Interacts with DDB1-CUL4A/B E3 ligase complexes.
    SequenceCaution:
    • Sequence=AAG35477.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH52301.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH63817.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO67709.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ74770.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=ABK41102.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14955.1; Type=Erroneous termination; Positions=274; Note=Translated as Lys.; Evidence={ECO:0000305}; Sequence=BAD93124.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR26 Gene

Proteomics data for WDR26 Gene at MOPED

Selected DME Specific Peptides for WDR26 Gene

Post-translational modifications for WDR26 Gene

  • Ubiquitination at Lys 212 and Lys 536
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR26 Gene

Domains & Families for WDR26 Gene

Gene Families for WDR26 Gene

Protein Domains for WDR26 Gene

Suggested Antigen Peptide Sequences for WDR26 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H7D7

UniProtKB/Swiss-Prot:

WDR26_HUMAN :
  • Contains 1 CTLH domain.
  • Contains 6 WD repeats.
Domain:
  • Contains 1 CTLH domain.
  • Contains 1 LisH domain.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR26: view

Function for WDR26 Gene

Molecular function for WDR26 Gene

UniProtKB/Swiss-Prot Function:
May be involved in MAPK pathways.

Enzyme Numbers (IUBMB) for WDR26 Gene

Gene Ontology (GO) - Molecular Function for WDR26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WDR26: view
genes like me logo Genes that share phenotypes with WDR26: view

Animal Model Products

miRNA for WDR26 Gene

miRTarBase miRNAs that target WDR26

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR26

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for WDR26 Gene

Localization for WDR26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR26 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR26 Gene COMPARTMENTS Subcellular localization image for WDR26 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for WDR26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 15378603
genes like me logo Genes that share ontologies with WDR26: view

Pathways & Interactions for WDR26 Gene

SuperPathways for WDR26 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR26 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR26 Gene

Drugs & Compounds for WDR26 Gene

No Compound Related Data Available

Transcripts for WDR26 Gene

Unigene Clusters for WDR26 Gene

WD repeat domain 26:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR26

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR26 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
SP1: - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for WDR26 Gene

GeneLoc Exon Structure for
WDR26
ECgene alternative splicing isoforms for
WDR26

Expression for WDR26 Gene

mRNA expression in normal human tissues for WDR26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR26 Gene

This gene is overexpressed in Cervix (25.7) and Peripheral blood mononuclear cells (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR26 Gene



SOURCE GeneReport for Unigene cluster for WDR26 Gene Hs.497873

mRNA Expression by UniProt/SwissProt for WDR26 Gene

Q9H7D7-WDR26_HUMAN
Tissue specificity: Broadly expressed, with highest levels in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with WDR26: view

Protein tissue co-expression partners for WDR26 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for WDR26 Gene

Orthologs for WDR26 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR26 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR26 35
  • 97.08 (n)
  • 99.81 (a)
WDR26 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR26 35
  • 95.2 (n)
  • 100 (a)
WDR26 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr26 35
  • 92.56 (n)
  • 97.75 (a)
Wdr26 16
Wdr26 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR26 35
  • 100 (n)
  • 100 (a)
WDR26 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr26 35
  • 92.93 (n)
  • 99.22 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR26 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR26 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR26 35
  • 87.1 (n)
  • 92.52 (a)
WDR26 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR26 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17077 35
wdr26 35
  • 81.91 (n)
  • 93.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6906 35
zebrafish
(Danio rerio)
Actinopterygii wdr26b 35
  • 74.17 (n)
  • 92.5 (a)
CABZ01044136.1 36
  • 82 (a)
OneToMany
wdr26b 36
  • 87 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006042 35
  • 59.22 (n)
  • 61.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7611 35
  • 57.21 (n)
  • 57.84 (a)
CG7611 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y39H10A.6 35
  • 41.82 (n)
  • 28 (a)
Y39H10A.6 36
  • 21 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GID7 36
  • 18 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G43920 35
  • 49.86 (n)
  • 40.82 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04101 35
  • 47.87 (n)
  • 44.64 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC343.04c 35
  • 45.28 (n)
  • 36.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2798 36
  • 56 (a)
OneToOne
Species with no ortholog for WDR26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR26 Gene

ENSEMBL:
Gene Tree for WDR26 (if available)
TreeFam:
Gene Tree for WDR26 (if available)

Paralogs for WDR26 Gene

(2) SIMAP similar genes for WDR26 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WDR26: view

No data available for Paralogs for WDR26 Gene

Variants for WDR26 Gene

Sequence variations from dbSNP and Humsavar for WDR26 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1058989 -- 224,387,183(-) CAGCC(A/C)CAAGA utr-variant-3-prime
rs1137390 -- 224,411,918(-) gctca(A/G)gcaat intron-variant
rs1972382 -- 224,401,690(-) TTTTT(C/T)TTTTT intron-variant, downstream-variant-500B
rs2211327 -- 224,430,796(+) CACCA(C/T)CATCT intron-variant
rs2405045 -- 224,409,988(-) ACTTA(C/T)TTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR26 Gene

Variant ID Type Subtype PubMed ID
nsv8868 CNV Loss 18304495
nsv469889 CNV Complex 16826518
nsv508062 CNV Loss 20534489
nsv160255 CNV Loss 16902084

Variation tolerance for WDR26 Gene

Residual Variation Intolerance Score: 18.06% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR26 Gene

HapMap Linkage Disequilibrium report
WDR26
Human Gene Mutation Database (HGMD)
WDR26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR26 Gene

Disorders for WDR26 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WDR26 Gene - From: GeneCards

Disorder Aliases PubMed IDs
klebsiella infection
  • klebsiella
- elite association
Search WDR26 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WDR26

Genetic Association Database (GAD)
WDR26
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR26
genes like me logo Genes that share disorders with WDR26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR26 Gene

Publications for WDR26 Gene

  1. Human heat shock protein 27 overexpressing mice are protected against hepatic ischemia and reperfusion injury. (PMID: 19461484) Chen S.W. … Lee H.T. (Transplantation 2009) 23 67
  2. Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection. (PMID: 19846873) Cai S. … Jeyaseelan S. (J. Immunol. 2009) 23 67
  3. Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis. (PMID: 17652447) Rajesh M. … Pacher P. (J. Leukoc. Biol. 2007) 23 67
  4. Activation of phosphatidylinositol 3-kinase and c-Jun-N-terminal kinase cascades enhances NF-kappaB-dependent gene transcription in BCG-stimulated macrophages through promotion of p65/p300 binding. (PMID: 14742634) Darieva Z. … Da Silva W.D. (J. Leukoc. Biol. 2004) 23 67
  5. Production of macrophage inflammatory protein-2 following hypoxia/reoxygenation in glial cells. (PMID: 11008215) Wang J.Y. … Wang J.Y. (Glia 2000) 23 67

Products for WDR26 Gene

Sources for WDR26 Gene

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