Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



WDR26 Gene

protein-coding   GIFtS: 53
GCID: GC01M224573

WD Repeat Domain 26

  Search for WDR26
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
WD Repeat Domain 261 2     GID72
Myocardial Ischemic Preconditioning Up-Regulated Protein 22 3     GID Complex Subunit 7 Homolog2
CDW22 3     Myocardial Ischemic Preconditioning Upregulated Protein 22
MIP22 3     WD Repeat-Containing Protein 262
CUL4- And DDB1-Associated WDR Protein 22 3     EC 1.4.4.28
GID Complex Subunit 7 Homolog (S. Cerevisiae)1     EC 2.7.7.88

External Ids:    HGNC: 212081   Entrez Gene: 802322   Ensembl: ENSG000001629237   UniProtKB: Q9H7D73   

Export aliases for WDR26 gene to outside databases

Previous GC identifers: GC01M220982 GC01M221550 GC01M221549 GC01M220881 GC01M222641 GC01M195092


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for WDR26 Gene:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of
approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation
of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular
processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript
variants encoding two different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for WDR26 Gene:
WDR26 (WD repeat domain 26) is a protein-coding gene.

UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7
Function: May be involved in MAPK pathways

Gene Wiki entry for WDR26 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_167186.2  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR26 gene promoter:
         NF-YB   Elk-1   CBF-B   CBF-A   Pax-5   NF-YA   Olf-1   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR26 promoter sequence
   Search Chromatin IP Primers for WDR26

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.13   Ensembl cytogenetic band:  1q42.12   HGNC cytogenetic band: 1q42.13

WDR26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR26 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M224573:  view genomic region     (about GC identifiers)

Start:
224,572,845 bp from pter      End:
224,624,735 bp from pter
Size:
51,891 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7 (See protein sequence)
Recommended Name: WD repeat-containing protein 26  
Size: 661 amino acids; 72124 Da
Subunit: Interacts with DDB1-CUL4A/B E3 ligase complexes
Sequence caution: Sequence=AAG35477.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH52301.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH63817.2;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAO67709.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAQ74770.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=ABK41102.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=BAB14955.1; Type=Erroneous termination; Positions=274; Note=Translated as Lys;
Sequence=BAD93124.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A0MNN3 Q4G100 Q59EC4 Q5GLZ9 Q86UY4 Q9H3C2
Alternative splicing: 4 isoforms:  Q9H7D7-1   Q9H7D7-2   Q9H7D7-3   Q9H7D7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR26: NX_Q9H7D7

Explore proteomics data for WDR26 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys212, Lys536
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for WDR26 (Q9H7D7)
     DDGTVRI  DLRAKAE 


    See WDR26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001108585.2  NP_079436.4  

    ENSEMBL proteins: 
     ENSP00000408108   ENSP00000424784   ENSP00000422758   ENSP00000403597   ENSP00000295024  
     ENSP00000355817  

    WDR26 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for WDR26
    OriGene Custom MassSpec
    OriGene Custom Protein Services for WDR26
    GenScript Custom Purified and Recombinant Proteins Services for WDR26
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WDR26

     
    Search eBioscience for Proteins for WDR26 

    WDR26 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for WDR26
    Novus Biologicals WDR26 Antibodies
    Abcam antibodies for WDR26
    Cloud-Clone Corp. Antibodies for WDR26
    Search ThermoFisher Antibodies for WDR26
    Search LSBio for Antibodies for WDR26

    WDR26 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for WDR26
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WDR26
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WDR26
    Cloud-Clone Corp. CLIAs for WDR26
    Search eBioscience for ELISAs for WDR26 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR006594 LisH_dimerisation
     IPR006595 CTLH_C
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9H7D7

    ProtoNet protein and cluster: Q9H7D7

    1 Blocks protein domain: IPB006595 CTLH

    UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7
    Similarity: Contains 1 CTLH domain
    Similarity: Contains 1 LisH domain
    Similarity: Contains 6 WD repeats


    Find genes that share domains with WDR26           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR26_HUMAN, Q9H7D7
    Function: May be involved in MAPK pathways

         Enzyme Numbers (IUBMB): EC 1.4.4.22 EC 2.7.7.82

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with WDR26           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for WDR26:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDR26
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WDR26

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WDR26
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WDR26

    miRNA
    Products:
        
    miRTarBase miRNAs that target WDR26:
    hsa-mir-93-5p (MIRT028144), hsa-let-7b-5p (MIRT052146), hsa-mir-30e-5p (MIRT044145), hsa-mir-92a-3p (MIRT049756), hsa-mir-19b-3p (MIRT031263), hsa-mir-140-3p (MIRT021671), hsa-mir-484 (MIRT041889)

    Block miRNA regulation of human, mouse, rat WDR26 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WDR26 (see all 92):
    hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-605 hsa-miR-30d hsa-miR-4267 hsa-miR-30a hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidWDR26 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WDR26
    Predesigned siRNA for gene silencing in human, mouse, rat WDR26

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WDR26

    Clone
    Products:
         
    OriGene clones in human, mouse for WDR26 (see all 13)
    OriGene ORF clones in mouse, rat for WDR26
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): WDR26 (NM_001115113)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDR26
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR26

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for WDR26
    Browse ESI BIO Cell Lines and PureStem Progenitors for WDR26 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR26


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    WDR26_HUMAN, Q9H7D7: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with WDR26           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR26
    Interactions:

        Search GeneGlobe Interaction Network for WDR26

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WDR26 (Q9H7D72, 3 ENSP000002950244) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8262165 I2D: score=2 
    RMND5AQ9H8713, ENSP000002836324I2D: score=3 STRING: ENSP00000283632
    FAF1Q9UNN53, ENSP000003794574I2D: score=2 STRING: ENSP00000379457
    GID8Q9NWU23, ENSP000002660694I2D: score=2 STRING: ENSP00000266069
    UBXN7O948883, ENSP000002963284I2D: score=2 STRING: ENSP00000296328
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR26



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for WDR26 gene (2 alternative transcripts): 
    NM_001115113.2  NM_025160.6  

    Unigene Cluster for WDR26:

    WD repeat domain 26
    Hs.497873  [show with all ESTs]
    Unigene Representative Sequence: NM_025160
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000414423(uc001hoq.4 uc001hop.4 uc021pjp.1) ENST00000480676
    ENST00000486652 ENST00000479727 ENST00000443112(uc009xei.2) ENST00000489825
    ENST00000477425 ENST00000445239 ENST00000479778(uc021pjt.1) ENST00000295024
    ENST00000366852
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat WDR26 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WDR26 (see all 92):
    hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-605 hsa-miR-30d hsa-miR-4267 hsa-miR-30a hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidWDR26 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WDR26
    Predesigned siRNA for gene silencing in human, mouse, rat WDR26
    Clone
    Products:
         
    OriGene clones in human, mouse for WDR26 (see all 13)
    OriGene ORF clones in mouse, rat for WDR26
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): WDR26 (NM_001115113)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDR26
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR26
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for WDR26
    OriGene qSTAR qPCR primer pairs in human, mouse for WDR26
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR26
      QuantiTect SYBR Green Assays in human, mouse, rat WDR26
      QuantiFast Probe-based Assays in human, mouse, rat WDR26

    Additional mRNA sequence: 

    AB209887.1 AB586698.1 AK023023.1 AK024669.1 AK027236.1 AK225061.1 AK299230.1 AK307909.1 
    AY221751.1 AY304473.1 BC031471.2 BC034498.1 BC041978.1 BC052301.1 BC063817.1 EF011612.1 

    15 DOTS entries:

    DT.100795905  DT.101975173  DT.95163085  DT.100795906  DT.100760675  DT.95102495  DT.91777951  DT.91912814 
    DT.121397840  DT.121397955  DT.213921  DT.97870627  DT.100653769  DT.95150875  DT.95255524 

    Selected AceView cDNA sequences (see all 395):

    AL596906 AW272297 BE503191 BG572627 N66685 R78253 AA703549 CB160531 
    BX375147 AA653488 AI953475 BC052301 AI291098 AI419745 BX496766 BQ228666 
    AI911525 BM698826 BE504952 AW028095 AL079981 AA935731 CB266486 BI917529 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WDR26 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
    SP1:                                      -                                                                                               -                     
    SP2:                                      -     -                                   -                 -                                   -                     
    SP3:                                            -                                   -                 -                                   -                     
    SP4:              -     -                       -                                                                                                               
    SP5:                          -                                                                                                                                 


    ECgene alternative splicing isoforms for WDR26

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    WDR26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGTGCGCA
    WDR26 Expression
    About this image


    WDR26 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Esophagus (Gastrointestinal Tract)
    WDR26 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR26 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497873

    UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7
    Tissue specificity: Broadly expressed, with highest levels in heart and skeletal muscle

        Custom PCR Arrays for WDR26
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for WDR26
    OriGene qSTAR qPCR primer pairs in human, mouse for WDR26
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR26
    QuantiTect SYBR Green Assays in human, mouse, rat WDR26
    QuantiFast Probe-based Assays in human, mouse, rat WDR26
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDR26 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr261 , 5 WD repeat domain 261, 5 92.56(n)1
    97.75(a)1
      1 (84.53 cM)5
    2267571  NM_145514.51  NP_663489.41 
     1811732285 
    chicken
    (Gallus gallus)
    Aves WDR261 WD repeat domain 26 87.1(n)
    92.52(a)
      421324  XM_419389.4  XP_419389.3 
    lizard
    (Anolis carolinensis)
    Reptilia WDR266
    WD repeat domain 26
    84(a)
    1 ↔ 1
    1(252659682-252703202)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.69062 Xenopus laevis transcribed sequence with strong similarity more 82.3(n)    BQ732006.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wdr26b1 WD repeat domain 26b 74.17(n)
    92.5(a)
      564794  NM_001202442.1  NP_001189371.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG76111 CG7611 57.21(n)
    57.84(a)
      40386  NM_168914.3  NP_730645.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y39H10A.61 Y39H10A.6 41.82(n)
    28(a)
      178791  NM_071638.5  NP_504039.4 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GID7(YCL039W)4 Protein of unknown function, involved in proteasome-dependent more   --   3(52645-54882) 850318  NP_009891.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G439201 AT5G43920 49.86(n)
    40.82(a)
      834414  NM_123759.2  NP_199205.1 


    ENSEMBL Gene Tree for WDR26 (if available)
    TreeFam Gene Tree for WDR26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for WDR26 gene
    2 SIMAP similar genes for WDR26 using alignment to 5 protein entries:     WDR26_HUMAN (see all proteins):
    POC1B    CORO1C

    Find genes that share paralogs with WDR26           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for WDR26 (see all 858)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs66728591,2
    C,F,A--224572470(+) GAGCCA/GAGATC 2 -- ds50016Minor allele frequency- G:0.25NA CSA 12
    rs1858612041,2
    --224572476(+) AGATCA/GCACGA 2 -- ds50010--------
    rs680453251,2
    C--224572538(-) TCATC-/TTTTTTTT
    /TTTTTTTTTT
    TTTTT
    2 -- ds50012NA 4
    rs127402551,2
    C,F,H--224572573(+) CACTGC/TTTCTT 2 -- ds500118Minor allele frequency- T:0.19NS EA NA CSA WA 2032
    rs1887767221,2
    --224572684(+) AGGCTG/TAGTCA 2 -- ds50010--------
    rs1996213171,2
    C--224572829(+) GGAGAC/TGTAAC 2 -- ds50010--------
    rs1489377681,2
    --224572874(+) TTGGAC/TTGAAA 2 -- ut310--------
    rs1923810481,2
    --224573034(+) TAAAAA/GTCAAC 2 -- ut310--------
    rs1838536091,2
    --224573189(+) CACCAA/CAATTG 2 -- ut310--------
    rs1881701341,2
    --224573378(+) CATGCC/TTTTGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for WDR26 (224572845 - 224624735 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for WDR26:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv160255CNV Loss16902084
    nsv508062CNV Loss20534489
    nsv8868CNV Loss18304495
    nsv469889CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR26
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR26

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus

    Find genes that share disorders with WDR26           About GenesLikeMe

    Genetic Association Database (GAD): WDR26

    Export disorders for WDR26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for WDR26 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with WDR26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PubMed id 17041588)1, 2 Higa L.A.... Zhang H. (Nat. Cell Biol. 2006)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. WDR26: a novel Gbeta-like protein, suppresses MAPK signaling pathway. (PubMed id 15378603)1, 2 Zhu Y.... Liu M. (J. Cell. Biochem. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    9. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    10. WDR26 functions as a scaffolding protein to promote GI^I^-mediated phospholipase C I^2 (PLCI^2) activation in leukocytes. (PubMed id 23625927)1 Sun Z....Chen S. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 80232 HGNC: 21208 AceView: WDR26 Ensembl:ENSG00000162923 euGenes: HUgn80232
    ECgene: WDR26 H-InvDB: WDR26

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for WDR26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for WDR26 gene:
    Search GeneIP for patents involving WDR26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for WDR26  
     OriGene qPCR primer pairs and template standards for WDR26   OriGene Protein Over-expression Lysate for WDR26  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for WDR26  
     OriGene qSTAR qPCR primer pairs in human, mouse for WDR26   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for WDR26   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for WDR26   OriGene Custom Protein Services for WDR26  

     
     
     Block miRNA regulation of human, mouse, rat WDR26 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing WDR26
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR26 Predesigned siRNA for gene silencing in human, mouse, rat WDR26
     QuantiFast Probe-based Assays in human, mouse, rat WDR26 QuantiTect SYBR Green Assays in human, mouse, rat WDR26
     Custom PCR Arrays for WDR26 Search Chromatin IP Primers for WDR26
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR26  Search GeneGlobe Interaction Network for WDR26
     Regulatory tfbs in WDR26 promoter
     GenScript Custom Purified and Recombinant Proteins Services for WDR26 GenScript cDNA clones with any tag delivered in your preferred vector for WDR26
     GenScript Custom Assay Services for WDR26 GenScript Custom overexpressing Cell Line Services for WDR26
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for WDR26
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     WDR26 antibodies
     Antibodies for WDR26
     See all of Abcam's Antibodies, Kits and Proteins for WDR26
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for WDR26
     Antibodies for WDR26
     ELISAs for WDR26
     CLIAs for WDR26



     Browse ESI BIO Cell Lines and PureStem Progenitors for WDR26
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR26
     SwitchGear 3'UTR luciferase reporter plasmids for WDR26
     SwitchGear Promoter luciferase reporter plasmids for WDR26
     Search ThermoFisher Antibodies for WDR26
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR26
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDR26
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WDR26
     Search LSBio for Antibodies for WDR26
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for WDR26
      Search eBioscience for proteins for WDR26
      Search eBioscience for elisas for WDR26
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      WDR26 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4