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Aliases & Descriptions for WDR26
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases CDW2 2 , 3 FLJ21016 1 , 2 MIP2 2 , 3 OTTHUMP00000035756 2
Descriptions CUL4- and DDB1-associated WDR protein 2 3 Myocardial ischemic preconditioning up-regulated protein 2 3 WD repeat domain 26 2 myocardial ischemic preconditioning upregulated protein 2 2
Search outside databases for aliases for WDR26 genePrevious GC identifers: GC01M220982 GC01M221550 GC01M221549 GC01M220881
Summaries for WDR26 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for WDR26 : This gene encodes a member of the WD repeat protein family. WD repeats are minimally conservedregions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), whichmay facilitate formation of heterotrimeric or multiprotein complexes. Members of this family areinvolved in a variety of cellular processes, including cell cycle progression, signaltransduction, apoptosis, and gene regulation. Two transcript variants encoding two differentisoforms have been found for this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7 Function : May be involved in MAPK pathways
Gene Wiki entry for WDR26
Genomic Location for WDR26
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
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Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the WDR26 gene Entrez Gene cytogenetic band: 1q42.11 Ensembl cytogenetic band: 1q42.11 HGNC cytogenetic band: 1q42.13 WDR26 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M222641:
(about GC identifiers )
Start:
222,639,728 bp from pter
End:
222,688,624 bp from pter
Size:
48,897 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.9 NT_004559.13 Proteins for WDR26
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
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Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
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R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
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Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7 (See
protein sequence )Recommended Name: WD repeat-containing protein 26 Size : 661 amino acids; 72124 Da
Subunit : Interacts with DDB1-CUL4A/B E3 ligase complexes
Subcellular location : Cytoplasm
Sequence caution : Sequence=BAB14955.1; Type=Erroneous termination; Positions=274; Note=Translatedas Lys;
Secondary accessions : A0MNN3 Q4G100 Q59EC4 Q5GLZ9 Q86UY4 Q9H3C2Alternative splicing : 4 isoforms : Q9H7D7-1 Q9H7D7-2 Q9H7D7-3 Q9H7D7-4
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001108585.1 NP_079436.3 ENSEMBL proteins: ENSP00000295024 ENSP00000355817 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
About this table Antibodies for WDR26: Assays for WDR26:
Protein
Domains/ Families for WDR26(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9H7D7 ProtoNet protein and cluster: Q9H7D7
1 Blocks protein family : IPB006595 CTLH UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7 Similarity : Contains 1 CTLH domainSimilarity : Contains 1 LisH domainSimilarity : Contains 6 WD repeats
Gene Function for WDR26
(According to MGI Jun 06 2009, UniProtKB ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_025160 Applied Biosystems Silencer ® siRNAs for WDR26 Sigma-Aldrich siRNA for WDR26 Sigma-Aldrich shRNA for WDR26 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001115113                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001115113                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001115113  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_025160 UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7 Function : May be involved in MAPK pathways
Pathways & Interactions for WDR26
(Pathways according to Invitrogen
(maps by GeneGo ),
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Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Drugs & Compounds for WDR26 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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Transcripts for WDR26(GenBank/EMBL/DDBJ Accessions according to
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DOTS (version 10), and/or
AceView ,
non coding RNAs according to
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exon structure from GeneLoc ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_025160 Sigma-Aldrich siRNA for WDR26 Sigma-Aldrich shRNA for WDR26 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001115113 NM_025160
REFSEQ mRNAs for WDR26 gene (2 alternative transcripts): NM_001115113.1 NM_025160.5
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001115113 NM_025160
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001115113                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001115113                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001115113  
Additional cDNA sequence: AB209887.1 AF130049.1 AK023023.1 AK024669.1 AK027236.1 AK225061.1 AK299230.1 AK307909.1 AY221751.1 AY304473.1 BC031471.2 BC034498.1 BC041978.1 BC052301.1 BC063817.1 CR593691.1 EF011612.1
24/34 DOTS entries (see all 34
): DT.100795905 DT.101975173 DT.95163085 DT.100795906 DT.100760675 DT.95102495 DT.40276008 DT.91777951 DT.121397955 DT.91912814 DT.121397840 DT.213921 DT.95150875 DT.97870627 DT.100653769 DT.100894033 DT.91967839 DT.95255524 DT.100893949 DT.100893975 DT.100894282 DT.100894389 DT.100894582 DT.100894636
24/395 AceView cDNA sequences (see all 395
):BF430930 AI493064 BM917729 BX111312 Z46059 AA134581 BQ072818 AI470408 AW088212 BG572627 BX496766 BQ018556 AW955764 BF732400 AI767639 AI333095 AI634544 AI467858 BX506802 AA724426 BE676146 AA291922 BE464371 BE645106
highest scoring ESTs for WDR26 :AA210688 AA633397 AA983250 AL042592 AY304473 BC034498 BC052301 BF509638 BF513485 BG718836
Unigene Cluster for WDR26: WD repeat domain 26 Hs.497873 [show with all ESTs ] Unigene Representative Sequence: AY221751 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for WDR26 (see all 6
) ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b SP1 :             -                                 -         SP2 :             -   -             -       -             -         SP3 :               -             -       -             -         SP4 :     -   -         -                                       SP5 :         -                                            
About this scheme ECgene alternative splicing isoforms for WDR26 2 Ensembl transcripts including schematic representations : ENST00000295024
ENST00000366852
Expression for WDR26
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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WDR26 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for WDR26 1 / 2 / 3
12 probe-sets matching WDR26 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.497873 UniProtKB/Swiss-Prot: WDR26_HUMAN, Q9H7D7 Tissue specificity : Broadly expressed, with highest levels in heart and skeletal muscle
Orthologs for WDR26
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
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Gene Trees according to Ensembl )
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Orthologs for WDR26 gene from 5/16 species (see all 16
)
About this table Species with no ortholog for WDR26 ENSEMBL Gene Tree for WDR26 Paralogs for WDR26 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for WDR26 gene FBXW5 2
SNPs/Variants for WDR26 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for WDR26 (up to first 250kb)
Disorders & Mutations for WDR26
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
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Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
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Medical News for WDR26 (Possibly Related Articles in
Doctor's Guide )
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Publications for WDR26 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/14 PubMed articles for WDR26 gene (see all 14
): CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PubMed id 17041588) 3, 4 Higa L.A.... Zhang H. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) WDR26: a novel Gbeta-like protein, suppresses MAPK signaling pathway. (PubMed id 15378603) 3, 4 Zhu Y.... Liu M. (2004) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 4 Aoki H.... Hino O. (2000) Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149) 3 Suzuki Y.... Sugano S. (1997) Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298) 3 Maruyama K. and Sugano S. (1994)
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Genome Databases showing WDR26
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Specialized Databases showing WDR26 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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