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Aliases for WDR26 Gene

Aliases for WDR26 Gene

  • WD Repeat Domain 26 2 3 5
  • CUL4- And DDB1-Associated WDR Protein 2 3 4
  • MIP2 3 4
  • CDW2 3 4
  • Myocardial Ischemic Preconditioning Up-Regulated Protein 2 4
  • Myocardial Ischemic Preconditioning Upregulated Protein 2 3
  • GID Complex Subunit 7 Homolog (S. Cerevisiae) 2
  • WD Repeat-Containing Protein 26 3
  • GID Complex Subunit 7 Homolog 3
  • EC 1.4.4.2 58
  • EC 2.7.7.8 58
  • SKDEAS 3
  • GID7 3

External Ids for WDR26 Gene

Previous GeneCards Identifiers for WDR26 Gene

  • GC01M220982
  • GC01M221550
  • GC01M221549
  • GC01M220881
  • GC01M222641
  • GC01M224573
  • GC01M195092

Summaries for WDR26 Gene

Entrez Gene Summary for WDR26 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR26 Gene

WDR26 (WD Repeat Domain 26) is a Protein Coding gene. Diseases associated with WDR26 include Skraban-Deardorff Syndrome and Klebsiella Infection.

UniProtKB/Swiss-Prot for WDR26 Gene

  • May be involved in MAPK pathways.

Gene Wiki entry for WDR26 Gene

Additional gene information for WDR26 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR26 Gene

Genomics for WDR26 Gene

Regulatory Elements for WDR26 Gene

Enhancers for WDR26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H224501 2 FANTOM5 Ensembl ENCODE dbSUPER 23.2 -66.3 -66320 3 HDGF FOXA2 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF766 NVL CICP5 LOC100287497 WDR26 CNIH4 GTF2IP20 CNIH3 CAPN2 GC01P224480 AKR1B1P1
GH01H224496 1.9 FANTOM5 Ensembl ENCODE dbSUPER 21.5 -62.2 -62151 4 PKNOX1 ATF1 ARNT FEZF1 ZNF2 ETS1 TCF12 CBX5 ZNF143 FOS CNIH4 WDR26 CICP5 NVL CNIH3 LOC100287497 GC01P224480 AKR1B1P1
GH01H223704 1.9 FANTOM5 Ensembl ENCODE dbSUPER 20.9 +730.0 729981 5 HDGF PKNOX1 FOXA2 ARNT SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS CICP5 CAPN2 LOC100287497 NVL WDR26 CNIH4 CAPN8 FBXO28 AIDA DISP1
GH01H223710 2 FANTOM5 Ensembl ENCODE dbSUPER 19.1 +720.7 720710 11 HDGF PKNOX1 FOXA2 ARNT ZFP64 SIN3A FEZF1 ZNF2 YY1 ZNF766 NVL CICP5 LOC100287497 CAPN2 TP53BP2 WDR26 CAPN8 GTF2IP20 FBXO28 RNU6-1248P
GH01H223844 1.7 FANTOM5 ENCODE dbSUPER 21 +591.3 591281 3 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 CICP5 NVL LOC100287497 CAPN2 FBXO28 TP53BP2 WDR26 CNIH4 GTF2IP20 GC01M223821
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR26 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR26 Gene

Chromosome:
1
Start:
224,385,143 bp from pter
End:
224,437,033 bp from pter
Size:
51,891 bases
Orientation:
Minus strand

Genomic View for WDR26 Gene

Genes around WDR26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR26 Gene

Proteins for WDR26 Gene

  • Protein details for WDR26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7D7-WDR26_HUMAN
    Recommended name:
    WD repeat-containing protein 26
    Protein Accession:
    Q9H7D7
    Secondary Accessions:
    • A0MNN3
    • Q4G100
    • Q59EC4
    • Q5GLZ9
    • Q86UY4
    • Q9H3C2

    Protein attributes for WDR26 Gene

    Size:
    661 amino acids
    Molecular mass:
    72124 Da
    Quaternary structure:
    • Interacts with DDB1-CUL4A/B E3 ligase complexes.
    SequenceCaution:
    • Sequence=AAG35477.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH52301.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH63817.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO67709.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ74770.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=ABK41102.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14955.1; Type=Erroneous termination; Positions=274; Note=Translated as Lys.; Evidence={ECO:0000305}; Sequence=BAD93124.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR26 Gene

Selected DME Specific Peptides for WDR26 Gene

Q9H7D7:
  • DLRAKAE
  • DDGTVRI

Post-translational modifications for WDR26 Gene

  • Ubiquitination at posLast=212212 and Lys536
  • Modification sites at PhosphoSitePlus

Domains & Families for WDR26 Gene

Gene Families for WDR26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR26 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR26: view

No data available for UniProtKB/Swiss-Prot for WDR26 Gene

Function for WDR26 Gene

Molecular function for WDR26 Gene

UniProtKB/Swiss-Prot Function:
May be involved in MAPK pathways.

Enzyme Numbers (IUBMB) for WDR26 Gene

Phenotypes From GWAS Catalog for WDR26 Gene

Gene Ontology (GO) - Molecular Function for WDR26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17510365
genes like me logo Genes that share ontologies with WDR26: view
genes like me logo Genes that share phenotypes with WDR26: view

Animal Model Products

CRISPR Products

miRNA for WDR26 Gene

miRTarBase miRNAs that target WDR26

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WDR26
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR26 Gene

Localization for WDR26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR26 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR26 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 15378603
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with WDR26: view

Pathways & Interactions for WDR26 Gene

SuperPathways for WDR26 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR26 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR26 Gene

Drugs & Compounds for WDR26 Gene

No Compound Related Data Available

Transcripts for WDR26 Gene

Unigene Clusters for WDR26 Gene

WD repeat domain 26:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WDR26
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for WDR26 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
SP1: - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for WDR26 Gene

GeneLoc Exon Structure for
WDR26
ECgene alternative splicing isoforms for
WDR26

Expression for WDR26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR26 Gene

This gene is overexpressed in Cervix (25.7) and Peripheral blood mononuclear cells (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR26 Gene



Protein tissue co-expression partners for WDR26 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR26 Gene:

WDR26

SOURCE GeneReport for Unigene cluster for WDR26 Gene:

Hs.497873

mRNA Expression by UniProt/SwissProt for WDR26 Gene:

Q9H7D7-WDR26_HUMAN
Tissue specificity: Broadly expressed, with highest levels in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for WDR26 Gene

  • Heart(4.4)
  • Lung(4.4)
  • Liver(4.3)
  • Nervous system(3.9)
  • Muscle(2)
genes like me logo Genes that share expression patterns with WDR26: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR26 Gene

Orthologs for WDR26 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR26 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia WDR26 33 34
  • 97.08 (n)
dog
(Canis familiaris)
Mammalia WDR26 33 34
  • 95.2 (n)
rat
(Rattus norvegicus)
Mammalia Wdr26 33
  • 92.93 (n)
mouse
(Mus musculus)
Mammalia Wdr26 33 16 34
  • 92.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR26 34
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR26 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR26 33 34
  • 87.1 (n)
lizard
(Anolis carolinensis)
Reptilia WDR26 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr26 33
  • 81.91 (n)
Str.17077 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6906 33
zebrafish
(Danio rerio)
Actinopterygii CABZ01044136.1 34
  • 82 (a)
OneToMany
wdr26b 33 34
  • 74.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006042 33
  • 59.22 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7611 33 34
  • 57.21 (n)
worm
(Caenorhabditis elegans)
Secernentea Y39H10A.6 33 34
  • 41.82 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GID7 34
  • 18 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G43920 33
  • 49.86 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2798 34
  • 56 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU04101 33
  • 47.87 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC343.04c 33
  • 45.28 (n)
Species where no ortholog for WDR26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR26 Gene

ENSEMBL:
Gene Tree for WDR26 (if available)
TreeFam:
Gene Tree for WDR26 (if available)

Paralogs for WDR26 Gene

(2) SIMAP similar genes for WDR26 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WDR26: view

No data available for Paralogs for WDR26 Gene

Variants for WDR26 Gene

Sequence variations from dbSNP and Humsavar for WDR26 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs796052140 Uncertain significance 224,431,492(-) ACGTT(G/T)TTGGG intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs796052210 Uncertain significance 224,434,047(-) AGGAG(A/G)AGGGG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1000053043 -- 224,406,419(+) AATGG(C/G)ATGAC intron-variant
rs1000082127 -- 224,400,875(+) TGAGT(A/C)AAGGA intron-variant
rs1000151898 -- 224,417,551(+) ACTTA(A/T)GAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR26 Gene

Variant ID Type Subtype PubMed ID
dgv149e212 CNV loss 25503493
nsv160255 CNV deletion 16902084
nsv469889 CNV gain 16826518
nsv475735 CNV novel sequence insertion 20440878
nsv508062 OTHER sequence alteration 20534489
nsv8868 CNV loss 18304495

Variation tolerance for WDR26 Gene

Residual Variation Intolerance Score: 18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR26 Gene

Human Gene Mutation Database (HGMD)
WDR26
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR26 Gene

Disorders for WDR26 Gene

MalaCards: The human disease database

(3) MalaCards diseases for WDR26 Gene - From: HGMD, OMIM, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
skraban-deardorff syndrome
klebsiella infection
  • klebsiella
chromosome 1q41-q42 deletion syndrome
  • 1q41-q42 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search WDR26 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WDR26

Genetic Association Database (GAD)
WDR26
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR26
genes like me logo Genes that share disorders with WDR26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR26 Gene

Publications for WDR26 Gene

  1. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PMID: 17041588) Higa LA … Zhang H (Nature cell biology 2006) 3 4 60
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. WDR26: a novel Gbeta-like protein, suppresses MAPK signaling pathway. (PMID: 15378603) Zhu Y … Liu M (Journal of cellular biochemistry 2004) 3 4 60

Products for WDR26 Gene

Sources for WDR26 Gene

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