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Aliases for WDR25 Gene

Aliases for WDR25 Gene

  • WD Repeat Domain 25 2 3 5
  • Chromosome 14 Open Reading Frame 67 2
  • C14orf67 3

External Ids for WDR25 Gene

Previous HGNC Symbols for WDR25 Gene

  • C14orf67

Previous GeneCards Identifiers for WDR25 Gene

  • GC14P099921
  • GC14P100995
  • GC14P101008
  • GC14P081024
  • GC14P101023
  • GC14P101034
  • GC14P101052
  • GC14P101078
  • GC14P101115
  • GC14P101164
  • GC14P101226
  • GC14P100377
  • GC14P100378

Summaries for WDR25 Gene

GeneCards Summary for WDR25 Gene

WDR25 (WD Repeat Domain 25) is a Protein Coding gene. An important paralog of this gene is CDC40.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR25 Gene

Genomics for WDR25 Gene

Regulatory Elements for WDR25 Gene

Promoters for WDR25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR25 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR25 Gene

Chromosome:
14
Start:
100,376,417 bp from pter
End:
100,530,303 bp from pter
Size:
153,887 bases
Orientation:
Plus strand

Genomic View for WDR25 Gene

Genes around WDR25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR25 Gene

Proteins for WDR25 Gene

  • Protein details for WDR25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q64LD2-WDR25_HUMAN
    Recommended name:
    WD repeat-containing protein 25
    Protein Accession:
    Q64LD2
    Secondary Accessions:
    • A8K7E5
    • Q6NVV6
    • Q86TQ4
    • Q9BTK5

    Protein attributes for WDR25 Gene

    Size:
    544 amino acids
    Molecular mass:
    60161 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR25 Gene

Proteomics data for WDR25 Gene at MOPED

Post-translational modifications for WDR25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR25 Gene

Domains & Families for WDR25 Gene

Gene Families for WDR25 Gene

Protein Domains for WDR25 Gene

Suggested Antigen Peptide Sequences for WDR25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q64LD2

UniProtKB/Swiss-Prot:

WDR25_HUMAN :
  • Contains 7 WD repeats.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR25: view

Function for WDR25 Gene

genes like me logo Genes that share phenotypes with WDR25: view

Animal Model Products

miRNA for WDR25 Gene

miRTarBase miRNAs that target WDR25

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR25 Gene

Localization for WDR25 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR25 Gene COMPARTMENTS Subcellular localization image for WDR25 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR25 Gene

Pathways & Interactions for WDR25 Gene

SuperPathways for WDR25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR25 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR25 Gene

Drugs & Compounds for WDR25 Gene

No Compound Related Data Available

Transcripts for WDR25 Gene

Unigene Clusters for WDR25 Gene

WD repeat domain 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR25 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1: - - - -
SP2:
SP3:

Relevant External Links for WDR25 Gene

GeneLoc Exon Structure for
WDR25
ECgene alternative splicing isoforms for
WDR25

Expression for WDR25 Gene

mRNA expression in normal human tissues for WDR25 Gene

Protein differential expression in normal tissues from HIPED for WDR25 Gene

This gene is overexpressed in Retina (48.6) and Blymphocyte (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR25 Gene



SOURCE GeneReport for Unigene cluster for WDR25 Gene Hs.497600

mRNA Expression by UniProt/SwissProt for WDR25 Gene

Q64LD2-WDR25_HUMAN
Tissue specificity: Expressed in heart, muscle, testis, ovary, uterus and prostate.
genes like me logo Genes that share expression patterns with WDR25: view

Protein tissue co-expression partners for WDR25 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WDR25 Gene

Orthologs for WDR25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR25 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR25 35
  • 79.54 (n)
  • 76.31 (a)
WDR25 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR25 35
  • 83.58 (n)
  • 80.37 (a)
WDR25 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr25 35
  • 81.12 (n)
  • 79.07 (a)
Wdr25 16
Wdr25 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR25 35
  • 99.19 (n)
  • 98.92 (a)
WDR25 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr25l 35
  • 80.05 (n)
  • 78.05 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR25 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR25 35
  • 59.23 (n)
  • 55.58 (a)
WDR25 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR25 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr25 35
  • 59.42 (n)
  • 55.98 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100534700 35
  • 58.4 (n)
  • 52.59 (a)
CABZ01085626.1 36
  • 52 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC40 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToOne
Species with no ortholog for WDR25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR25 Gene

ENSEMBL:
Gene Tree for WDR25 (if available)
TreeFam:
Gene Tree for WDR25 (if available)

Paralogs for WDR25 Gene

Paralogs for WDR25 Gene

genes like me logo Genes that share paralogs with WDR25: view

Variants for WDR25 Gene

Sequence variations from dbSNP and Humsavar for WDR25 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2181170 - 100,381,186(-) TCCCC(A/G)ATCGC intron-variant, upstream-variant-2KB, reference, missense
rs2273800 - 100,381,370(-) GAGCA(C/T)GGAAA intron-variant, upstream-variant-2KB, reference, missense
rs2273801 - 100,381,100(-) CTGCT(C/T)TGGGC intron-variant, upstream-variant-2KB, reference, missense
rs34331240 - 100,381,280(+) GTGGA(C/T)GAGCC intron-variant, upstream-variant-2KB, reference, missense
rs13065 -- 100,529,975(-) GGGTG(A/G/T)TAGGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for WDR25 Gene

Variant ID Type Subtype PubMed ID
esv34023 CNV Loss 18971310
esv1950925 CNV Deletion 18987734
esv2749109 CNV Deletion 23290073
esv2669876 CNV Deletion 23128226
esv1006795 CNV Deletion 20482838
esv9060 CNV Loss 19470904
esv1625148 CNV Deletion 17803354
nsv819726 CNV Loss 19587683
esv2749110 CNV Deletion 23290073
esv2749111 CNV Deletion 23290073
nsv521690 CNV Loss 19592680
dgv1980n71 CNV Loss 21882294
nsv902232 CNV Loss 21882294
nsv509548 CNV Insertion 20534489
esv1346244 CNV Insertion 17803354
nsv456427 CNV Loss 19166990

Variation tolerance for WDR25 Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR25 Gene

HapMap Linkage Disequilibrium report
WDR25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR25 Gene

Disorders for WDR25 Gene

Relevant External Links for WDR25

Genetic Association Database (GAD)
WDR25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR25

No disorders were found for WDR25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR25 Gene

Publications for WDR25 Gene

  1. A novel human gene (WDR25) encoding a 7-WD40-containing protein maps on 14q32. (PMID: 15587985) Jin F. … Mao Y. (Biochem. Genet. 2004) 2 3 4 67
  2. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry J.R. … Ong K.K. (Nature 2014) 3
  3. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. (PMID: 25356737) Jung J.G. … Wang T.L. (PLoS Genet. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for WDR25 Gene

Sources for WDR25 Gene

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