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WDR25 Gene

protein-coding GIFtS: 43

GC14P099921

WD repeat domain 25
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC4645 ^¹, ²

Descriptions
WD repeat domain 25 ^²
pre-mRNA splicing factor-like ^²

External Ids
HGNC: 21064¹
Entrez Gene: 79446²
UniProtKB: Q64LD2³
Ensembl: ENSG00000176473⁷

Search outside databases for aliases for WDR25 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the WDR25 gene

Entrez Gene cytogenetic band: 14q32.2 Ensembl cytogenetic band: 14q32.2 HGNC cytogenetic band: 14q32.32

WDR25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P099921: (about GC identifiers)

Start:	99,912,546 bp from pter
End:	100,066,393 bp from pter
Size:	153,848 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WDR25_HUMAN, Q64LD2 (See protein sequence)

Recommended Name: WD repeat-containing protein 25

Size: 544 amino acids; 60161 Da

Secondary accessions: Q6NVV6 Q86TQ4 Q9BTK5

Alternative splicing: 3 isoforms: Q64LD2-1 Q64LD2-2 Q64LD2-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_078791.2

ENSEMBL proteins:

ENSP00000334148 ENSP00000385540

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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	Browse recombinant and purified proteins available from Enzo Life Sciences
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	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for WDR25:

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	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for WDR25

Assays for WDR25:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q64LD2

ProtoNet protein and cluster: Q64LD2

UniProtKB/Swiss-Prot: WDR25_HUMAN, Q64LD2

Similarity: Contains 7 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR25)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_024515

Applied Biosystems Silencer® siRNAs for WDR25

Sigma-Aldrich siRNA for WDR25

Sigma-Aldrich shRNA for WDR25

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for WDR25
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_024515
Myc/DDK tagged cDNA clone in CMV expression vector: NM_024515
untagged cDNA clones in CMV expression vector (see all 2): BC003641

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_024515

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for WDR25 (Q64LD2²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
PSME3 P61289² MINT-66537
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR25

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR25)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_024515

Sigma-Aldrich siRNA for WDR25

Sigma-Aldrich shRNA for WDR25

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_024515

REFSEQ mRNAs for WDR25 gene:

NM_024515.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_024515

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024515
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024515
                                 untagged cDNA clones in CMV expression vector (see all 2): BC003641

Additional cDNA sequence:

AK291960.1 AY295082.1 BC003641.2 BC007953.2 BX248767.1 CR600063.1 CR621842.1

13 DOTS entries:

DT.100772484 DT.100781045 DT.443027 DT.102831052 DT.91735589 DT.95375232 DT.120758921 DT.120758926

DT.100733064 DT.120758883 DT.120758901 DT.92466976 DT.100720017

24/102 AceView cDNA sequences (see all 102 ):

F08937 BQ950764 CR600063 BX248767 BC003641 BF513170 CR621842 BM455328

AY295082 BX368302 AA358470 NM_024515 AW955247 BX399568 BE267252 CA432028

BG702523 AA766086 BM986939 BI552728 BQ055101 BX367872 BX483756 BX325608

highest scoring ESTs for WDR25:

AI261823 AI580921 AW955247 BC003641 BC007953 BI118071 BI755602 BQ014278 F08937 AA044106

Unigene Cluster for WDR25:

WD repeat domain 25

Hs.497600 [show with all ESTs]

Unigene Representative Sequence: AY295082

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for WDR25

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9
SP1:			-		-		-												-
SP2:
SP3:

About this scheme

ECgene alternative splicing isoforms for WDR25

2 Ensembl transcripts including schematic representations:

ENST00000335290 ENST00000402312

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR25 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for WDR25

¹ / ² / ³

3 probe-sets matching WDR25 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
60831_at²^{, 3}	U95-C	1	1.00	1.00	1.00	1.00	AI261823	1.00	1.00	1.00	1
219609_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_024515	0.60	1.00	0.82	1
219609_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAGATCTGGC

SOURCE GeneReport for Unigene cluster: Hs.497600
UniProtKB/Swiss-Prot: WDR25_HUMAN, Q64LD2
Tissue specificity: Expressed in heart, muscle, testis, ovary, uterus and prostate

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WDR25 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WDR25¹	--	WD repeat domain 25	83.58(n) 80.19(a)	490858 XM_547980.2 XP_547980.2
chimpanzee (Pan troglodytes)	WDR25¹	--	WD repeat domain 25	93.63(n) 93.2(a)	743142 XM_001159477.1 XP_001159477.1
cow (Bos taurus)	WDR25¹	--	WD repeat domain 25	79.69(n) 76.11(a)	527651 XM_606048.3 XP_606048.3
mouse (Mus musculus)	Wdr25^{1, 5}	12⁵	WD repeat domain 25^{1, 5}	81.12(n)¹ 78.88(a)¹	212198¹ XM_001474974.1¹ XP_001475024.1¹ AK081117⁵ AK147993⁵ (see all 7)
chicken (Gallus gallus)	WDR25¹	--	WD repeat domain 25	58.97(n) 54.82(a)	428908 XM_426463.2 XP_426463.2

About this table Species with no ortholog for WDR25

ENSEMBL Gene Tree for WDR25

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for WDR25 gene

CDC40²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/605 NCBI SNPs in WDR25 are shown (see all 605 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 195)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2273801^1,2	C,F,H	99917190(-)	`CTGCTT/CTGGGC`	1	R/K	mis¹ ese³		10		EA EU WA NA	2404
	rs2273800^1,2	C,F,H	99917460(-)	`GAGCAT/CGGAAA`	1	R/H	mis¹		17		EA NA EU WA	2966
	rs2181170^1,2	C,H	99917276(-)	`TCCCCG/AATCGC`	1	W/R	mis¹		4		EU EA WA	418
	rs34331240^1,2	C,F	99917370(+)	`GTGGAC/TGAGCC`	1	T/M	mis¹		5		NA EU EA WA	496
	rs10149134^1,2	A,C	100066435(+)	`TCCCAA/GGCCTG`	1	--	ng3¹		0	--	--	--	--
	rs13065^1,2	A,C,F,H	100066065(-)	`GGGTGG/ATAGGT`	1	Y/Y	syn¹		13		MN NA EU EA WA	1232
	rs3742387^1,2	A,C,F,H	99917683(+)	`CAGCCA/GTATTT`	1	P/P	syn¹ ese³		24		EA NA EU WA	2252
	rs35447854^1,2	F	100065205(+)	`CCCGTG/ATTCCT`	1	V/V	syn¹		1		NA	78
	rs8005782^1,2	A,C,F,H	100006546(+)	`TCTCAG/ATCAAC`	1	--	int¹		11		NA EU EA WA	980
	rs11624049^1,2	A,C,F,H	99922573(+)	`TTGCTT/CCATCA`	1	--	int¹		6		EU EA WA NA	596

About this table

HapMap Linkage Disequilibrium images for WDR25 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for WDR25 gene:

A novel human gene (WDR25) encoding a 7-WD40-containing protein maps on 14q32. (PubMed id 15587985)^{2, 3, 4} Jin F.... Mao Y. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling. (PubMed id 17053785)⁴ Wang Y.... Chen Z. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 79446	HGNC: 21064	AceView: MGC4645	Ensembl:ENSG00000176473	euGenes: HUgn79446
ECgene: WDR25	H-InvDB: WDR25

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for WDR25
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for WDR25:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for WDR25-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for WDR25		Antibodies for WDR25
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WDR25 Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for WDR25

Summaries
for WDR25

Genomic Location
for WDR25

Proteins
for WDR25

Protein Domains/
Families
for WDR25

Gene Function
for WDR25

Pathways & Interactions
for WDR25

Drugs & Compounds
for WDR25

Transcripts
for WDR25

Expression
for WDR25

Orthologs
for WDR25

Paralogs
for WDR25

SNPs/Variants
for WDR25

Disorders & Mutations
for WDR25

Medical News
for WDR25

Publications
for WDR25

Search for WDR25

Genome Databases showing WDR25

Other Databases showing WDR25

Specialized Databases showing WDR25

Licensable Technologies
for WDR25

Services
for WDR25

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WDR25 Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor WDR25

Summariesfor WDR25

Genomic Locationfor WDR25

Proteinsfor WDR25

Protein Domains/Familiesfor WDR25

Gene Functionfor WDR25

Pathways & Interactionsfor WDR25

Drugs & Compoundsfor WDR25

Transcriptsfor WDR25

Expression for WDR25

Orthologsfor WDR25

Paralogsfor WDR25

SNPs/Variantsfor WDR25

Disorders & Mutationsfor WDR25

Medical Newsfor WDR25

Publicationsfor WDR25

Search for WDR25

Genome Databases showing WDR25

Other Databases showing WDR25

Specialized Databases showing WDR25

Licensable Technologiesfor WDR25

Servicesfor WDR25

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for WDR25

Summaries
for WDR25

Genomic Location
for WDR25

Proteins
for WDR25

Protein Domains/
Families
for WDR25

Gene Function
for WDR25

Pathways & Interactions
for WDR25

Drugs & Compounds
for WDR25

Transcripts
for WDR25

Expression
for WDR25

Orthologs
for WDR25

Paralogs
for WDR25

SNPs/Variants
for WDR25

Disorders & Mutations
for WDR25

Medical News
for WDR25

Publications
for WDR25

Licensable Technologies
for WDR25

Services
for WDR25