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Aliases for WDR25 Gene

Aliases for WDR25 Gene

  • WD Repeat Domain 25 2 3 5
  • Chromosome 14 Open Reading Frame 67 2
  • WD Repeat-Containing Protein 25 3
  • C14orf67 3

External Ids for WDR25 Gene

Previous HGNC Symbols for WDR25 Gene

  • C14orf67

Previous GeneCards Identifiers for WDR25 Gene

  • GC14P099921
  • GC14P100995
  • GC14P101008
  • GC14P081024
  • GC14P101023
  • GC14P101034
  • GC14P101052
  • GC14P101078
  • GC14P101115
  • GC14P101164
  • GC14P101226
  • GC14P100377
  • GC14P100378
  • GC14P100379
  • GC14P100380

Summaries for WDR25 Gene

GeneCards Summary for WDR25 Gene

WDR25 (WD Repeat Domain 25) is a Protein Coding gene. An important paralog of this gene is CDC40.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR25 Gene

Genomics for WDR25 Gene

Regulatory Elements for WDR25 Gene

Enhancers for WDR25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F100405 1.7 FANTOM5 Ensembl ENCODE 35.2 +31.8 31840 6.1 HDGF PKNOX1 MLX CREB3L1 ARID4B DMAP1 SLC30A9 FOS ZNF263 SP3 WDR25 WARS SLC25A47 LOC105370664 HMGN1P25
GH14F100401 0.5 Ensembl ENCODE 28.3 +26.8 26784 3.6 SMARCA5 PKNOX1 CREB3L1 ZBTB11 CEBPB ZBTB7A SP1 RAD51 ZNF318 SCRT2 WDR25 WARS SLC25A47 GC14P100409
GH14F099821 0.6 Ensembl 24.6 -554.4 -554417 0.4 PKNOX1 SIN3A FEZF1 ZNF2 GLIS2 ZNF302 GATA2 KLF7 ZNF263 SP3 WDR25 ENSG00000258672 ENSG00000258560 ENSG00000258383 RN7SL523P ENSG00000237342 ENSG00000229402 EML1 HHIPL1 CYP46A1
GH14F100434 1.8 FANTOM5 Ensembl ENCODE 24 +62.7 62684 10.2 PKNOX1 MLX ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 ZNF143 FOS WDR25 BEGAIN WARS SLC25A47 LOC105370664 HMGN1P25
GH14F100371 0.5 ENCODE 23.9 -1.5 -1513 6.5 PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 WARS WDR25 SLC25A29 MIR6764 GC14P100382
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around WDR25 on UCSC Golden Path with GeneCards custom track

Promoters for WDR25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000181659 -917 4201 PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF207 ZNF143

Genomic Location for WDR25 Gene

100,376,417 bp from pter
100,530,303 bp from pter
153,887 bases
Plus strand

Genomic View for WDR25 Gene

Genes around WDR25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR25 Gene

Proteins for WDR25 Gene

  • Protein details for WDR25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 25
    Protein Accession:
    Secondary Accessions:
    • A8K7E5
    • Q6NVV6
    • Q86TQ4
    • Q9BTK5

    Protein attributes for WDR25 Gene

    544 amino acids
    Molecular mass:
    60161 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR25 Gene


neXtProt entry for WDR25 Gene

Post-translational modifications for WDR25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR25 Gene

Domains & Families for WDR25 Gene

Gene Families for WDR25 Gene

Protein Domains for WDR25 Gene

Suggested Antigen Peptide Sequences for WDR25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 7 WD repeats.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR25: view

Function for WDR25 Gene

Gene Ontology (GO) - Molecular Function for WDR25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with WDR25: view
genes like me logo Genes that share phenotypes with WDR25: view

Animal Model Products

miRNA for WDR25 Gene

miRTarBase miRNAs that target WDR25

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR25 Gene

Localization for WDR25 Gene

Subcellular locations from

Jensen Localization Image for WDR25 Gene COMPARTMENTS Subcellular localization image for WDR25 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR25 Gene

Pathways & Interactions for WDR25 Gene

SuperPathways for WDR25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR25 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR25 Gene

Transcripts for WDR25 Gene

Unigene Clusters for WDR25 Gene

WD repeat domain 25:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR25 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1: - - - -

Relevant External Links for WDR25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR25 Gene

mRNA expression in normal human tissues for WDR25 Gene

Protein differential expression in normal tissues from HIPED for WDR25 Gene

This gene is overexpressed in Retina (48.6) and Blymphocyte (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR25 Gene

Protein tissue co-expression partners for WDR25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR25 Gene:


SOURCE GeneReport for Unigene cluster for WDR25 Gene:


mRNA Expression by UniProt/SwissProt for WDR25 Gene:

Tissue specificity: Expressed in heart, muscle, testis, ovary, uterus and prostate.
genes like me logo Genes that share expression patterns with WDR25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WDR25 Gene

Orthologs for WDR25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR25 34 35
  • 99.19 (n)
(Canis familiaris)
Mammalia WDR25 34 35
  • 83.58 (n)
(Mus musculus)
Mammalia Wdr25 34 16 35
  • 81.12 (n)
(Rattus norvegicus)
Mammalia Wdr25l 34
  • 80.05 (n)
(Bos Taurus)
Mammalia WDR25 34 35
  • 79.54 (n)
(Monodelphis domestica)
Mammalia WDR25 35
  • 50 (a)
(Gallus gallus)
Aves WDR25 34 35
  • 59.23 (n)
(Anolis carolinensis)
Reptilia WDR25 35
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr25 34
  • 59.42 (n)
(Danio rerio)
Actinopterygii LOC100534700 34
  • 58.4 (n)
CABZ01085626.1 35
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC40 35
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
Species where no ortholog for WDR25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR25 Gene

Gene Tree for WDR25 (if available)
Gene Tree for WDR25 (if available)

Paralogs for WDR25 Gene

Paralogs for WDR25 Gene

genes like me logo Genes that share paralogs with WDR25: view

Variants for WDR25 Gene

Sequence variations from dbSNP and Humsavar for WDR25 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs796052162 Likely benign 100,468,038(+) GTGGA(A/C)TCCGG reference, missense
rs10129340 -- 100,466,369(+) CATTC(A/G)GGACT intron-variant
rs10130199 -- 100,512,520(+) ataaa(C/T)tttat intron-variant
rs10132528 -- 100,525,030(+) TGGCG(C/G)CCCAG intron-variant
rs10133183 -- 100,484,882(+) CCTTG(C/G)AGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR25 Gene

Variant ID Type Subtype PubMed ID
dgv1130n106 CNV deletion 24896259
dgv3898n54 CNV loss 21841781
esv1006795 CNV deletion 20482838
esv1346244 CNV insertion 17803354
esv1625148 CNV deletion 17803354
esv1950925 CNV deletion 18987734
esv2669876 CNV deletion 23128226
esv2749109 CNV deletion 23290073
esv2749110 CNV deletion 23290073
esv2749111 CNV deletion 23290073
esv2856680 CNV duplication 24192839
esv3244051 CNV deletion 24192839
esv34023 CNV loss 18971310
esv3552053 CNV deletion 23714750
esv3635506 CNV gain 21293372
esv3635507 CNV loss 21293372
esv3635509 CNV gain 21293372
esv9060 CNV loss 19470904
nsv1069818 CNV deletion 25765185
nsv1120302 CNV tandem duplication 24896259
nsv1125593 CNV tandem duplication 24896259
nsv1138331 CNV deletion 24896259
nsv1138332 CNV deletion 24896259
nsv1151478 CNV deletion 26484159
nsv456427 CNV loss 19166990
nsv478653 CNV novel sequence insertion 20440878
nsv509548 CNV insertion 20534489
nsv521690 CNV loss 19592680
nsv819726 CNV loss 19587683
nsv952240 CNV deletion 24416366
nsv958726 CNV deletion 24416366
nsv974371 CNV duplication 23825009

Variation tolerance for WDR25 Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR25 Gene

Disorders for WDR25 Gene

Relevant External Links for WDR25

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WDR25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR25 Gene

Publications for WDR25 Gene

  1. A novel human gene (WDR25) encoding a 7-WD40-containing protein maps on 14q32. (PMID: 15587985) Jin F. … Mao Y. (Biochem. Genet. 2004) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry J.R. … Ong K.K. (Nature 2014) 3 64
  4. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. (PMID: 25356737) Jung J.G. … Wang T.L. (PLoS Genet. 2014) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for WDR25 Gene

Sources for WDR25 Gene

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