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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR25 Gene

protein-coding   GIFtS: 45
GCID: GC14P101164

WD Repeat Domain 25

(Previous name: chromosome 14 open reading frame 67)
(Previous symbol: C14orf67)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WD Repeat Domain 251 2
C14orf671 2
Chromosome 14 Open Reading Frame 671
WD Repeat-Containing Protein 252

External Ids:    HGNC: 210641   Entrez Gene: 794462   Ensembl: ENSG000001764737   UniProtKB: Q64LD23   

Export aliases for WDR25 gene to outside databases

Previous GC identifers: GC14P099921 GC14P100995 GC14P101008 GC14P081024 GC14P101023 GC14P101034 GC14P101052 GC14P101078 GC14P101115


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for WDR25 Gene: 
WDR25 (WD repeat domain 25) is a protein-coding gene. Diseases associated with WDR25 include prostatitis. An important paralog of this gene is CDC40.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR25 gene promoter:
         STAT1   STAT1alpha   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR25 promoter sequence
   Search SABiosciences Chromatin IP Primers for WDR25

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.32

WDR25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR25 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P101164:  view genomic region     (about GC identifiers)

Start:
100,842,755 bp from pter      End:
100,996,640 bp from pter
Size:
153,886 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WDR25_HUMAN, Q64LD2 (See protein sequence)
Recommended Name: WD repeat-containing protein 25  
Size: 544 amino acids; 60161 Da
Secondary accessions: A8K7E5 Q6NVV6 Q86TQ4 Q9BTK5
Alternative splicing: 2 isoforms:  Q64LD2-1   Q64LD2-2   

Explore the universe of human proteins at neXtProt for WDR25: NX_Q64LD2

Explore proteomics data for WDR25 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q64LD2

  • WDR25 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WDR25 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001154948.1  NP_078791.3  

    ENSEMBL proteins: 
     ENSP00000450661   ENSP00000385540   ENSP00000334148   ENSP00000450727   ENSP00000451070  
     ENSP00000441903   ENSP00000452235  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q64LD2

    ProtoNet protein and cluster: Q64LD2

    UniProtKB/Swiss-Prot: WDR25_HUMAN, Q64LD2
    Similarity: Contains 7 WD repeats


    WDR25 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    WDR25 for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR25

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for WDR25 (Q64LD22, 3 ENSP000003341484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSME3P612892, 3, ENSP000002933624MINT-66537 I2D: score=5 STRING: ENSP00000293362
    KBTBD7Q8WVZ93I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR25

    Search CenterWatch for drugs/clinical trials and news about WDR25

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WDR25 gene (2 alternative transcripts): 
    NM_001161476.1  NM_024515.4  

    Unigene Cluster for WDR25:

    WD repeat domain 25
    Hs.497600  [show with all ESTs]
    Unigene Representative Sequence: NM_024515
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555775 ENST00000554998(uc021sbq.1) ENST00000402312(uc010avx.3 uc010avy.3)
    ENST00000335290(uc001yhn.3) ENST00000554492 ENST00000554175 ENST00000557710
    ENST00000542471(uc001yho.3) ENST00000555865 ENST00000557502 ENST00000555201

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate WDR25:
    hsa-miR-4286
    SwitchGear 3'UTR luciferase reporter plasmidWDR25 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR25
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR25
    Sirion Biotech Customized lentivirus for stable overexpression of WDR25 
                         Customized lentivirus expression plasmids for stable overexpression of WDR25 
    Primer
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    OriGene qPCR primer pairs and template standards for WDR25
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR25

    Additional mRNA sequence: 

    AK291960.1 AY295082.1 BC003641.2 BC007953.2 BX248767.1 

    13 DOTS entries:

    DT.100772484  DT.100781045  DT.443027  DT.102831052  DT.91735589  DT.95375232  DT.120758921  DT.120758926 
    DT.100720017  DT.100733064  DT.120758883  DT.120758901  DT.92466976 

    24/102 AceView cDNA sequences (see all 102):

    AA358470 BQ950764 BC003641 BX368302 BM455328 CR621842 F08937 CR600063 
    BX248767 BF513170 AY295082 NM_024515 BQ061089 BM919464 BG337082 BX399568 
    AI672752 BX367872 BM710213 BM043871 BX326006 AA766086 AW955247 AL709941 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for WDR25    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
    SP1:        -     -     -                                   -         
    SP2:                                                                  
    SP3:                                                                  


    ECgene alternative splicing isoforms for WDR25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATCTGGC
    WDR25 Expression
    About this image


    See WDR25 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR25

    SOURCE GeneReport for Unigene cluster: Hs.497600

    UniProtKB/Swiss-Prot: WDR25_HUMAN, Q64LD2
    Tissue specificity: Expressed in heart, muscle, testis, ovary, uterus and prostate

        SABiosciences Custom PCR Arrays for WDR25
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR25

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDR25 gene from 8/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr251 , 5 WD repeat domain 251, 5 81.12(n)1
    79.07(a)1
      12 (59.70 cM)5
    2121981  NM_177602.31  NP_808270.21 
     1088942725 
    chicken
    (Gallus gallus)
    Aves WDR251 WD repeat domain 25 59.04(n)
    54.82(a)
      428908  XM_426463.3  XP_426463.2 
    lizard
    (Anolis carolinensis)
    Reptilia WDR256
    Uncharacterized protein
    68(a)
    1 ↔ 1
    GL343270.1(770981-804526)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005347001 WD repeat-containing protein 25-like 58.4(n)
    52.59(a)
      100534700  XM_003200284.1  XP_003200332.1 
    worm
    (Caenorhabditis elegans)
    Secernentea prp-176
    Y54G2A.126
    Protein Y54G2A.12
    19(a)
    16(a)
    many → 1
    many → 1
    I(10936821-10940521)
    IV(2777220-2782824)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC406
    Pre-mRNA splicing factor, important for catalytic ...
    16(a)
    1 → many
    IV(1202843-1204210)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G545201 transducin/WD40 domain-containing protein 44.8(n)
    36.66(a)
      835540  NM_124832.2  NP_200263.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g03198001 hypothetical protein 46.21(n)
    37.66(a)
      4329163  NM_001053217.1  NP_001046682.1 


    ENSEMBL Gene Tree for WDR25 (if available)
    TreeFam Gene Tree for WDR25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WDR25 gene
    CDC402  

    WDR25 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2972 SNPs in WDR25 are shown (see all 2972)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838979531,2
    --100844711(+) ATGTTG/TGCCAG 2 -- int10--------
    rs1887447801,2
    --100844816(+) ATTTTG/TTTTAA 2 -- int10--------
    rs1925138131,2
    --100845021(+) CCGGGC/TGCGGT 2 -- int10--------
    rs128829341,2
    C,F,A,H--100845457(+) ACCTAC/ACCTCG 2 -- int126Minor allele frequency- A:0.13NS EA NA WA CSA 2766
    rs609170041,2
    C,F--100845465(+) TCGTTC/TATGAT 2 -- int14Minor allele frequency- T:0.14WA CSA EA 242
    rs1824970781,2
    --100845511(+) GTGCGG/TCAGGT 2 -- int10--------
    rs1483300871,2
    --100845704(+) ATTGTA/CTCTTC 2 -- int10--------
    rs2004139151,2
    C--100845728(+) TTTTC-/TTTTTT 2 -- int10--------
    rs1867662791,2
    --100845763(+) TCTGTC/TACTCA 2 -- int10--------
    rs1414426111,2
    --100845819(+) TCCCGG/TGTTCA 2 -- int10--------

    HapMap Linkage Disequilibrium report for WDR25 (100842755 - 100996640 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for WDR25 (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749110CNV Deletion23290073
    esv2669876CNV Deletion23128226
    esv1006795CNV Deletion20482838
    esv1950925CNV Deletion18987734
    esv1625148CNV Deletion17803354
    esv2749109CNV Deletion23290073
    esv2749111CNV Deletion23290073
    esv1346244CNV Insertion17803354
    nsv509548CNV Insertion20534489
    esv34023CNV Loss18971310

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for WDR25:    About MalaCards
    prostatitis    


    WDR25 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WDR25

    Export disorders for WDR25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR25 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with WDR25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human gene (WDR25) encoding a 7-WD40-containing protein maps on 14q32. (PubMed id 15587985)1, 2, 3 Jin F.... Mao Y. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (2007)
    4. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    6. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79446 HGNC: 21064 AceView: MGC4645 Ensembl:ENSG00000176473 euGenes: HUgn79446
    ECgene: WDR25 H-InvDB: WDR25

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WDR25 gene:
    Search GeneIP for patents involving WDR25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Proteins for WDR25
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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