WDR24 Gene
protein-coding GIFtS: 44
GCID: GC16M000734
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|
WD repeat domain 24(Previous name: chromosome 16 open reading frame 21 )
(Previous symbol: C16orf21)
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Aliases
for WDR24 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 241 2 | | C16orf211 2 3 | | JFP71 2 | | DKFZp434F0541 | | Chromosome 16 Open Reading Frame 211 | | WD Repeat-Containing Protein 242 |
Export aliases for WDR24 gene to outside databasesPrevious GC identifers: GC00U911617 GC16M000675 GC16M000677 GC16M000656 |
Summaries
for WDR24 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for WDR24
|
Genomic Views
for WDR24 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR24 gene promoter:
NF-1 AP-1 Pax-5 Sp1 CUTL1 CREB deltaCREB c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR24
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR24 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3WDR24 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M000734: view genomic region
(about GC identifiers)
Start:
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734,622 bp from pter |
End:
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740,444 bp from pter |
Size:
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5,823 bases |
Orientation:
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minus strand |
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Proteins
for WDR24 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR24_HUMAN, Q96S15 (See
protein sequence)Recommended Name: WD repeat-containing protein 24 Size: 920 amino acids; 101989 Da
Secondary accessions: A2IDB8 D3DU59 Q96GC7 Q9H0B7Alternative splicing: 2 isoforms: Q96S15-1 Q96S15-2 Explore the universe of human proteins at neXtProt for WDR24: NX_Q96S15
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96S15
WDR24 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115635.1
ENSEMBL proteins: ENSP00000293883 ENSP00000248142
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005777 | peroxisome |
IEA | -- |
WDR24 for ontologies About GeneDecksing
WDR24 Antibody Products:
Assay Products for WDR24: |
Protein
Domains /
Families
for WDR24 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR24 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96S15ProtoNet protein and cluster: Q96S15 UniProtKB/Swiss-Prot: WDR24_HUMAN, Q96S15Similarity: Belongs to the WD repeat WDR24 familySimilarity: Contains 6 WD repeats |
Function
for WDR24 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR24 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR24
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WDR24 (NM_032259) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR24 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR24 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR24 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005053 | peroxisome matrix targeting signal-2 binding |
IEA | -- |
WDR24 for ontologies About GeneDecksing
|
Pathways & Interactions
for WDR24 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR24
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/15 Interacting proteins for WDR24 (Q96S152, 3 ENSP000002938834) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016558 | protein import into peroxisome matrix |
IEA | -- |
WDR24 for ontologies About GeneDecksing
|
Drugs & Compounds
for WDR24 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR24
Search CenterWatch for drugs/clinical trials and news about WDR24
|
Transcripts
for WDR24 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR24 gene: NM_032259.2 Unigene Cluster for WDR24: WD repeat domain 24 Hs.459632 [show with all ESTs]Unigene Representative Sequence: AK1248873 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000293883(uc002ciz.1) ENST00000567014 ENST00000248142
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR24 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR24
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WDR24 (NM_032259) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR24 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR24 |
Additional cDNA sequence: AK124887.1 AK301146.1 AL136863.1 BC008025.1 BC009761.2 7 DOTS entries: DT.413349 DT.100667139 DT.95368214 DT.413348 DT.100772253 DT.95235558 DT.95235589 24/590 AceView cDNA sequences (see all 590): BU633100 BE671298 BM142155 BM543990 BQ898858 BU858211 F08841 BQ068044 BM127160 AI378598 BQ581532 BQ671851 AW081519 BU162270 BQ641450 AW572300 BM979638 CK819928 AL045079 AI869896 BQ129173 BM714930 AI537602 CD251875
GeneLoc Exon Structure
|
Expression
for WDR24 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGTGGCTGG
About this image
See WDR24 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR24
SOURCE GeneReport for Unigene cluster: Hs.459632
SABiosciences Custom PCR Arrays for WDR24
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR24
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR24 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR24 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR24 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR24 |
Orthologs
for WDR24 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for WDR24 gene from 6/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
WDR241 |
WD repeat domain 24 |
82.05(n)
81.96(a) |
|
416406 NM_001030628.1 NP_001025799.1 |
lizard
(Anolis carolinensis) |
Reptilia |
WDR246 |
-- |
71(a) |
1 ↔ 1 |
GL344401.1(22714-31661) |
African clawed frog
(Xenopus laevis) |
Amphibia |
mgc47001-prov2 |
hypothetical protein MGC53421 |
74.28(n) |
|
BC046252.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.54002 |
Danio rerio mRNA similar to hypothetical protein MGC47 more |
76.45(n) |
|
BC045501.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG76091 |
CG7609 |
51.39(n)
40.77(a) |
|
43505 NM_143463.4 NP_651720.3 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y32H12A.86 |
Protein Y32H12A.8 |
4(a) |
1 ↔ 1 |
III(5385578-5404946) |
ENSEMBL Gene Tree for WDR24 (if available)
TreeFam Gene Tree for WDR24 (if available) |
Paralogs
for WDR24 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WDR24 gene
- WDR592
WDR24 for paralogs About GeneDecksing
|
Genomic Variants
for WDR24 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR24 (734622 - 740444 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for WDR24
11 CNVs: 49738 49727 29986 49728 3987 29982 5329 30732 29983 29985 32070 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR24 |
|
Disorders
/ Diseases
for WDR24 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for WDR24 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR24 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with WDR24) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for WDR24 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR24 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR24 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR24 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR24 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR24 gene:
Search GeneIP for patents involving WDR24
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR24 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WDR24 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDR24 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR24 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WDR24 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR24 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR24 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for WDR24 | | OriGene Custom Protein Services for WDR24 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR24 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR24 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR24 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR24 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR24 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR24 |
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 |  |  |  | |
| | | | Search Tocris compounds for WDR24 |
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 | | | WDR24 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR24 |
|  |  |  | | | | Search ThermoFisher Antibodies for WDR24 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR24 |
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