Aliases for WDR24 Gene
External Ids for WDR24 Gene
Previous HGNC Symbols for WDR24 Gene
Previous GeneCards Identifiers for WDR24 Gene
GeneCards Summary for WDR24 Gene
WDR24 (WD Repeat Domain 24) is a Protein Coding gene. Among its related pathways are mTOR signaling pathway (KEGG).
UniProtKB/Swiss-Prot for WDR24 Gene
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).