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WDR24 Gene

protein-coding GIFtS: 46

GC16M000675

WD repeat domain 24
(Previous name: chromosome 16 open reading frame 21 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C16orf21)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
C16orf21 ^²
DKFZp434F054 ^¹, ²
JFP7 ^¹, ²

Descriptions
WD repeat domain 24 ^²
chromosome 16 open reading frame 21 ^¹

External Ids
HGNC: 20852¹
Entrez Gene: 84219²
UniProtKB: Q96S15³
Ensembl: ENSG00000127580⁷

Search outside databases for aliases for WDR24 gene

Previous GC identifer: GC00U911617

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for WDR24

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the WDR24 gene

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

WDR24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M000675: (about GC identifiers)

Start:	674,623 bp from pter
End:	680,445 bp from pter
Size:	5,823 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000016.8 NT_037887.4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WDR24_HUMAN, Q96S15 (See protein sequence)

Recommended Name: WD repeat-containing protein 24

Size: 920 amino acids; 101989 Da

Secondary accessions: Q96GC7 Q9H0B7

Alternative splicing: 2 isoforms: Q96S15-1 Q96S15-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_115635.1

ENSEMBL proteins:

ENSP00000293883 ENSP00000248142

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (WDR24)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for WDR24:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for WDR24

Assays for WDR24:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q96S15

ProtoNet protein and cluster: Q96S15

UniProtKB/Swiss-Prot: WDR24_HUMAN, Q96S15

Similarity: Belongs to the WD repeat WDR24 family

Similarity: Contains 6 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR24)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032259

Applied Biosystems Silencer® siRNAs for WDR24

Sigma-Aldrich siRNA and siRNA Panels for WDR24

Sigma-Aldrich shRNA for WDR24

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for WDR24
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_032259
Myc/DDK tagged cDNA clone in CMV expression vector: NM_032259
untagged cDNA clone in CMV expression vector: NM_032259

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_032259

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for WDR24 (Q96S15²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
APPBP2 Q92624² MINT-66841
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR24

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR24)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032259

Sigma-Aldrich siRNA and siRNA Panels for WDR24

Sigma-Aldrich shRNA for WDR24

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_032259

REFSEQ mRNAs for WDR24 gene:

NM_032259.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_032259

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032259
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_032259
                                 untagged cDNA clone in CMV expression vector: NM_032259

Additional cDNA sequence:

AK124887.1 AK301146.1 AL136863.1 BC008025.1 BC009761.2

7 DOTS entries:

DT.413349 DT.100667139 DT.95368214 DT.413348 DT.100772253 DT.95235558 DT.95235589

24/590 AceView cDNA sequences (see all 590 ):

CK823614 F08841 BM554498 AI991501 BI763811 AI537602 AF370420 BQ691472

AI218039 BQ007031 BQ898858 BX361982 AL045079 BF593699 AI378598 BU948644

AL041138 AW959861 BC034014 AI241750 AI300906 BI916836 BX333485 BQ641450

highest scoring ESTs for WDR24:

AI820052 AL136863 BC008025 AL045079 AL045083 AW163613 BE272891 BE295111 BE873454 BF313928

Unigene Cluster for WDR24:

WD repeat domain 24

Hs.459632 [show with all ESTs]

Unigene Representative Sequence: AK124887

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000293883 ENST00000248142

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR24 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for WDR24

¹ / ² / ³

4 probe-sets matching WDR24 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
48491_at²^{, 3}	U95-B	1	1.00	1.00	0.94	0.87	AI820052	0.80	1.00	0.91	1
68512_at²^{, 3}	U95-E	1	0.69	1.00	0.63	1.13	AA558980	0.60	0.83	0.73	1
223293_at²^{, 3}	U133-B	2	1.00	0.95	--	--	AL136863	0.80	1.00	0.91	1
223293_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks WDR24 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAGTGGCTGG

SOURCE GeneReport for Unigene cluster: Hs.459632

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WDR24 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WDR24¹	--	WD repeat domain 24	88.91(n) 94.77(a)	479891 XM_537017.2 XP_537017.2
cow (Bos taurus)	WDR24¹	--	WD repeat domain 24	89.7(n) 95.82(a)	507528 NM_001045973.1 NP_001039438.1
rat (Rattus norvegicus)	Wdr24¹	--	WD repeat domain 24	87(n) 96.46(a)	360497 XM_001063483.1 XP_001063483.1
mouse (Mus musculus)	Wdr24^{1, 5}	17⁵	WD repeat domain 24^{1, 5}	86.37(n)¹ 95.57(a)¹	268933¹ NM_173741.2¹ NP_776102.1¹ AK078694⁵ AK170253⁵ (see all 11)
chicken (Gallus gallus)	WDR24¹	--	WD repeat domain 24	82.05(n) 81.96(a)	416406 NM_001030628.1 NP_001025799.1

About this table Species with no ortholog for WDR24

ENSEMBL Gene Tree for WDR24

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for WDR24 gene

WDR59²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/24 NCBI SNPs in WDR24 are shown (see all 24 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 25)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4984682^1,2	A,C,F,H	680405(+)	`GCTGTG/CTTTCC`	1	--	ng3¹ ese³		4		EU EA WA	412
	rs4984913^1,2	A,C,F,H	680467(+)	`GCACAG/AACTCT`	1	--	ng3¹		4		EU EA WA	420
--	rs11860172^1,2	A,C	680869(+)	`cctccC/Tgaagt`	1	--	ng3¹		0	--	--	--	--
--	rs8044597^1,2	A,C	680882(+)	`tgggaA/Ttgcag`	1	--	ng3¹		0	--	--	--	--
--	rs11865690^1,2	A,C	680683(+)	`gcaacC/Ttccac`	1	--	ng3¹		0	--	--	--	--
	rs1018804^1,2	A,C,F,H	677794(-)	`GAGGGT/CGCACC`	1	--	int¹		4		EU EA WA	418
	rs10903019^1,2	A,C	676448(+)	`AGCTCA/CCGGCT`	1	--	int¹		0	--	--	--	--
--	rs6600230^1,2	C	678478(+)	`TTAGTA/GGATAT`	1	--	int¹		0	--	--	--	--
--	rs58433639^1,2	--	679875(+)	`CTGAGA/CGGTGA`	1	--	ut5¹		0	--	--	--	--
--	rs13330131^1,2	--	679908(+)	`GGCCTC/GTCAGT`	1	--	ut5¹ ese³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for WDR24 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

8 PubMed articles for WDR24 gene:

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{2, 3, 4} Wiemann S.... Poustka A. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)^{3, 4} Daniels R.J....Higgs D.R. (2001)
The LIFEdb database in 2006. (PubMed id 16381901)³ Mehrle A....Wiemann S. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)³ Wiemann S....Poustka A. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)³ Hartley J.L....Brasch M.A. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 84219	HGNC: 20852	AceView: DKFZp434F054andFBXL16andLOC339123	Ensembl:ENSG00000127580	euGenes: HUgn84219
ECgene: WDR24	H-InvDB: WDR24

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for WDR24
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for WDR24:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for WDR24-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for WDR24		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for WDR24		Browse small molecules at Sigma-Aldrich
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (WDR24)
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Search Tocris compounds for WDR24

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for WDR24

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WDR24 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for WDR24

Summaries
for WDR24

Genomic Location
for WDR24

Proteins
for WDR24

Protein Domains/
Families
for WDR24

Gene Function
for WDR24

Pathways & Interactions
for WDR24

Drugs & Compounds
for WDR24

Transcripts
for WDR24

Expression
for WDR24

Orthologs
for WDR24

Paralogs
for WDR24

SNPs/Variants
for WDR24

Disorders & Mutations
for WDR24

Medical News
for WDR24

Publications
for WDR24

Search for WDR24

Genome Databases showing WDR24

Other Databases showing WDR24

Specialized Databases showing WDR24

Licensable Technologies
for WDR24

Services
for WDR24

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WDR24 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor WDR24

Summariesfor WDR24

Genomic Locationfor WDR24

Proteinsfor WDR24

Protein Domains/Familiesfor WDR24

Gene Functionfor WDR24

Pathways & Interactionsfor WDR24

Drugs & Compoundsfor WDR24

Transcriptsfor WDR24

Expression for WDR24

Orthologsfor WDR24

Paralogsfor WDR24

SNPs/Variantsfor WDR24

Disorders & Mutationsfor WDR24

Medical Newsfor WDR24

Publicationsfor WDR24

Search for WDR24

Genome Databases showing WDR24

Other Databases showing WDR24

Specialized Databases showing WDR24

Licensable Technologiesfor WDR24

Servicesfor WDR24

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for WDR24

Summaries
for WDR24

Genomic Location
for WDR24

Proteins
for WDR24

Protein Domains/
Families
for WDR24

Gene Function
for WDR24

Pathways & Interactions
for WDR24

Drugs & Compounds
for WDR24

Transcripts
for WDR24

Expression
for WDR24

Orthologs
for WDR24

Paralogs
for WDR24

SNPs/Variants
for WDR24

Disorders & Mutations
for WDR24

Medical News
for WDR24

Publications
for WDR24

Licensable Technologies
for WDR24

Services
for WDR24