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WDR24 Gene

protein-coding   GIFtS: 46

GC16M000675
WD repeat domain 24
(Previous name: chromosome 16 open reading frame 21 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C16orf21)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
C16orf21 2
DKFZp434F054 1, 2
JFP7 1, 2
Descriptions
WD repeat domain 24 2
chromosome 16 open reading frame 21 1
External Ids
HGNC: 208521
Entrez Gene: 842192
UniProtKB: Q96S153
Ensembl: ENSG000001275807
Search outside databases for aliases for WDR24 gene

Previous GC identifer: GC00U911617

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for WDR24
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WDR24 gene  

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

WDR24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M000675:     (about GC identifiers)

Start:
674,623 bp from pter
End:
680,445 bp from pter
Size:
5,823 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000016.8  NT_037887.4  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WDR24_HUMAN, Q96S15 (See protein sequence)
Recommended Name: WD repeat-containing protein 24  
Size: 920 amino acids; 101989 Da
Secondary accessions: Q96GC7 Q9H0B7
Alternative splicing: 2 isoforms:  Q96S15-1   Q96S15-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_115635.1  

    ENSEMBL proteins: 
    ENSP00000293883 ENSP00000248142 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (WDR24)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for WDR24: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for WDR24

    Assays for WDR24: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR019782 WD40_repeat_2
     IPR019775 WD40_repeat_CS
     IPR019781 WD40_repeat_sg
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_region


       GeneDecks  WDR24 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q96S15

    ProtoNet protein and cluster: Q96S15

    UniProtKB/Swiss-Prot: WDR24_HUMAN, Q96S15
    Similarity: Belongs to the WD repeat WDR24 family
    Similarity: Contains 6 WD repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WDR24)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032259

                  Applied Biosystems Silencer® siRNAs for WDR24

                  Sigma-Aldrich siRNA and siRNA Panels for WDR24  
                         Sigma-Aldrich shRNA for WDR24  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for WDR24
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_032259
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_032259
                                     untagged cDNA clone in CMV expression vector: NM_032259 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_032259

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    1 Interacting protein for WDR24 (Q96S152) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPBP2Q926242MINT-66841
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for WDR24

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WDR24)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032259

                  Sigma-Aldrich siRNA and siRNA Panels for WDR24  
                         Sigma-Aldrich shRNA for WDR24  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_032259  

    REFSEQ mRNAs for WDR24 gene: 

    NM_032259.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_032259  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_032259
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_032259
                                     untagged cDNA clone in CMV expression vector: NM_032259 

    Additional cDNA sequence: 

    AK124887.1 AK301146.1 AL136863.1 BC008025.1 BC009761.2 

    7 DOTS entries:

    DT.413349  DT.100667139  DT.95368214  DT.413348  DT.100772253  DT.95235558  DT.95235589 

    24/590 AceView cDNA sequences (see all 590 ):

    CK823614 F08841 BM554498 AI991501 BI763811 AI537602 AF370420 BQ691472 
    AI218039 BQ007031 BQ898858 BX361982 AL045079 BF593699 AI378598 BU948644 
    AL041138 AW959861 BC034014 AI241750 AI300906 BI916836 BX333485 BQ641450 

    highest scoring ESTs for WDR24:

    AI820052 AL136863 BC008025 AL045079 AL045083 AW163613 BE272891 BE295111 BE873454 BF313928 

    Unigene Cluster for WDR24:

    WD repeat domain 24
    Hs.459632  [show with all ESTs]
    Unigene Representative Sequence: AK124887


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000293883  ENST00000248142  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    WDR24 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for WDR24

    1 / 2 / 3

    4 probe-sets matching WDR24 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    48491_at2, 3 U95-B 1 1.00 1.00 0.94 0.87 AI820052 0.80 1.00 0.91 1
    68512_at2, 3 U95-E 1 0.69 1.00 0.63 1.13 AA558980 0.60 0.83 0.73 1

    223293_at2, 3 U133-B 2 1.00 0.95 -- -- AL136863 0.80 1.00 0.91 1

    223293_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
    GeneDecks  WDR24 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AAGTGGCTGG

    SOURCE GeneReport for Unigene cluster: Hs.459632
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for WDR24 gene from 5/12 species (see all 12 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    WDR241   -- WD repeat domain 24 88.91(n)
    94.77(a)
    479891  XM_537017.2  XP_537017.2 
    cow
    (Bos taurus)
    WDR241   -- WD repeat domain 24 89.7(n)
    95.82(a)
    507528  NM_001045973.1  NP_001039438.1 
    rat
    (Rattus norvegicus)
    Wdr241   -- WD repeat domain 24 87(n)
    96.46(a)
    360497  XM_001063483.1  XP_001063483.1 
    mouse
    (Mus musculus)
    Wdr241, 5 175
    WD repeat domain 241, 5 86.37(n)1
    95.57(a)1
    2689331  NM_173741.21  NP_776102.11 
     AK0786945  AK1702535  (see all 11)
    chicken
    (Gallus gallus)
    WDR241   -- WD repeat domain 24 82.05(n)
    81.96(a)
    416406  NM_001030628.1  NP_001025799.1 
    About this table        Species with no ortholog for WDR24

    ENSEMBL Gene Tree for WDR24
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for WDR24 gene
    WDR592  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/24 NCBI SNPs in WDR24 are shown (see all 24 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 25)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 16 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs49846821,2
    A,C,F,H680405(+) GCTGTG/CTTTCC 1 -- ng31 ese34Minor allele frequency- C:0.49EU EA WA 412
    rs49849131,2
    A,C,F,H680467(+) GCACAG/AACTCT 1 -- ng314Minor allele frequency- A:0.33EU EA WA 420
    --
    rs118601721,2
    A,C680869(+) cctccC/Tgaagt 1 -- ng310--------
    --
    rs80445971,2
    A,C680882(+) tgggaA/Ttgcag 1 -- ng310--------
    --
    rs118656901,2
    A,C680683(+) gcaacC/Ttccac 1 -- ng310--------
    rs10188041,2
    A,C,F,H677794(-) GAGGGT/CGCACC 1 -- int14Minor allele frequency- C:0.43EU EA WA 418
    rs109030191,2
    A,C676448(+) AGCTCA/CCGGCT 1 -- int10--------
    --
    rs66002301,2
    C678478(+) TTAGTA/GGATAT 1 -- int10--------
    --
    rs584336391,2
    --679875(+) CTGAGA/CGGTGA 1 -- ut510--------
    --
    rs133301311,2
    --679908(+) GGCCTC/GTCAGT 1 -- ut51 ese30--------
    About this table

    HapMap Linkage Disequilibrium images for WDR24 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    8 PubMed articles for WDR24 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 84219 HGNC: 20852 AceView: DKFZp434F054andFBXL16andLOC339123 Ensembl:ENSG00000127580 euGenes: HUgn84219
    ECgene: WDR24 H-InvDB: WDR24
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for WDR24:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for WDR24-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for WDR24 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for WDR24 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search Novus for antibodies for WDR24

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