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Aliases for WDR24 Gene

Aliases for WDR24 Gene

  • WD Repeat Domain 24 2 3 5
  • C16orf21 3 4
  • Chromosome 16 Open Reading Frame 21 2
  • JFP7 3

External Ids for WDR24 Gene

Previous HGNC Symbols for WDR24 Gene

  • C16orf21

Previous GeneCards Identifiers for WDR24 Gene

  • GC00U911617
  • GC16M000675
  • GC16M000677
  • GC16M000734
  • GC16M000656
  • GC16M000709
  • GC16M000743

Summaries for WDR24 Gene

GeneCards Summary for WDR24 Gene

WDR24 (WD Repeat Domain 24) is a Protein Coding gene. An important paralog of this gene is WDR59.

UniProtKB/Swiss-Prot for WDR24 Gene

  • As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway.

Gene Wiki entry for WDR24 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR24 Gene

Genomics for WDR24 Gene

Regulatory Elements for WDR24 Gene

Enhancers for WDR24 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR24 on UCSC Golden Path with GeneCards custom track

Promoters for WDR24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR24 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR24 Gene

684,622 bp from pter
690,649 bp from pter
6,028 bases
Minus strand

Genomic View for WDR24 Gene

Genes around WDR24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR24 Gene

Proteins for WDR24 Gene

  • Protein details for WDR24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 24
    Protein Accession:
    Secondary Accessions:
    • A2IDB8
    • D3DU59
    • Q96GC7
    • Q9H0B7

    Protein attributes for WDR24 Gene

    920 amino acids
    Molecular mass:
    101989 Da
    Quaternary structure:
    • Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers.

    Alternative splice isoforms for WDR24 Gene


neXtProt entry for WDR24 Gene

Proteomics data for WDR24 Gene at MOPED

Post-translational modifications for WDR24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR24 Gene

Domains & Families for WDR24 Gene

Gene Families for WDR24 Gene

Protein Domains for WDR24 Gene

Suggested Antigen Peptide Sequences for WDR24 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat WDR24 family.
  • Contains 6 WD repeats.
  • Belongs to the WD repeat WDR24 family.
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR24: view

Function for WDR24 Gene

Molecular function for WDR24 Gene

UniProtKB/Swiss-Prot Function:
As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway.

Phenotypes for WDR24 Gene

genes like me logo Genes that share phenotypes with WDR24: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR24 Gene

Localization for WDR24 Gene

Subcellular locations from

Jensen Localization Image for WDR24 Gene COMPARTMENTS Subcellular localization image for WDR24 gene
Compartment Confidence
cytosol 2
mitochondrion 2
extracellular 1
lysosome 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR24 Gene

Pathways & Interactions for WDR24 Gene

SuperPathways for WDR24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR24 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR24 Gene

Drugs & Compounds for WDR24 Gene

No Compound Related Data Available

Transcripts for WDR24 Gene

Unigene Clusters for WDR24 Gene

WD repeat domain 24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR24 Gene

No ASD Table

Relevant External Links for WDR24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR24 Gene

mRNA expression in normal human tissues for WDR24 Gene

Protein differential expression in normal tissues from HIPED for WDR24 Gene

This gene is overexpressed in Placenta (13.9), Plasma (13.3), Blymphocyte (10.1), Pancreas (9.7), CD8 Tcells (6.3), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR24 Gene

SOURCE GeneReport for Unigene cluster for WDR24 Gene Hs.459632

genes like me logo Genes that share expression patterns with WDR24: view

Protein tissue co-expression partners for WDR24 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR24 Gene

Orthologs for WDR24 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR24 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR24 35
  • 89.7 (n)
  • 95.82 (a)
WDR24 36
  • 96 (a)
(Canis familiaris)
Mammalia WDR24 35
  • 88.91 (n)
  • 94.77 (a)
WDR24 36
  • 86 (a)
(Mus musculus)
Mammalia Wdr24 35
  • 86.37 (n)
  • 95.57 (a)
Wdr24 16
Wdr24 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Wdr24 35
  • 87 (n)
  • 96.46 (a)
(Monodelphis domestica)
Mammalia WDR24 36
  • 86 (a)
(Pan troglodytes)
Mammalia WDR24 36
  • 79 (a)
(Gallus gallus)
Aves WDR24 35
  • 82.05 (n)
  • 81.96 (a)
WDR24 36
  • 82 (a)
(Anolis carolinensis)
Reptilia WDR24 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr24 35
  • 74.31 (n)
  • 80.67 (a)
African clawed frog
(Xenopus laevis)
Amphibia mgc47001-prov 35
(Danio rerio)
Actinopterygii Dr.5400 35
wdr24 35
  • 72.75 (n)
  • 72.8 (a)
wdr24 36
  • 71 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001159 35
  • 50.14 (n)
  • 42.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7609 35
  • 51.25 (n)
  • 40.27 (a)
CG7609 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea Y32H12A.8 36
  • 3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTC5 36
  • 10 (a)
RTC1 38
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC4F8.11 35
  • 36.72 (n)
  • 28.69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for WDR24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR24 Gene

Gene Tree for WDR24 (if available)
Gene Tree for WDR24 (if available)

Paralogs for WDR24 Gene

Paralogs for WDR24 Gene

genes like me logo Genes that share paralogs with WDR24: view

Variants for WDR24 Gene

Sequence variations from dbSNP and Humsavar for WDR24 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs13330131 -- 689,907(+) GGCCT(C/G)TCAGT utr-variant-5-prime
rs9932631 -- 691,837(+) ctttc(A/G)cccag upstream-variant-2KB
rs1018804 -- 687,793(-) GAGGG(C/T)GCACC intron-variant
rs4984682 -- 690,404(+) GCTGT(C/G)TTTCC utr-variant-5-prime
rs17850290 -- 687,269(+) GAGCA(C/T)GTGGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for WDR24 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904707 CNV Loss 21882294
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
dgv2479n71 CNV Loss 21882294
nsv471063 CNV Loss 18288195
dgv2485n71 CNV Loss 21882294
nsv904759 CNV Loss 21882294
dgv2487n71 CNV Loss 21882294
nsv516590 CNV Loss 19592680
dgv2488n71 CNV Loss 21882294
nsv904781 CNV Gain 21882294
nsv471065 CNV Gain 18288195
nsv904785 CNV Gain+Loss 21882294
dgv2490n71 CNV Loss 21882294
nsv9321 CNV Gain+Loss 18304495
dgv2491n71 CNV Loss 21882294
nsv904796 CNV Loss 21882294
nsv904797 CNV Loss 21882294
dgv2492n71 CNV Loss 21882294
nsv904799 CNV Loss 21882294
nsv827480 CNV Gain 20364138
dgv2493n71 CNV Loss 21882294
dgv2494n71 CNV Loss 21882294
nsv457311 CNV Loss 19166990
nsv482183 CNV Gain 20164927
nsv827482 CNV Loss 20364138
dgv454n67 CNV Gain 20364138

Variation tolerance for WDR24 Gene

Residual Variation Intolerance Score: 7.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.13; 84.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WDR24 Gene

Disorders for WDR24 Gene

Relevant External Links for WDR24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WDR24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR24 Gene

Publications for WDR24 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3
  3. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for WDR24 Gene

Sources for WDR24 Gene