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Aliases for WDR24 Gene

Aliases for WDR24 Gene

  • WD Repeat Domain 24 2 3 5
  • C16orf21 3 4
  • Chromosome 16 Open Reading Frame 21 2
  • WD Repeat-Containing Protein 24 3
  • JFP7 3

External Ids for WDR24 Gene

Previous HGNC Symbols for WDR24 Gene

  • C16orf21

Previous GeneCards Identifiers for WDR24 Gene

  • GC00U911617
  • GC16M000675
  • GC16M000677
  • GC16M000734
  • GC16M000656
  • GC16M000709
  • GC16M000743
  • GC16M000814
  • GC16M000837
  • GC16M000855

Summaries for WDR24 Gene

GeneCards Summary for WDR24 Gene

WDR24 (WD Repeat Domain 24) is a Protein Coding gene. Among its related pathways are mTOR signaling pathway (KEGG). An important paralog of this gene is WDR59.

UniProtKB/Swiss-Prot for WDR24 Gene

  • As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).

Gene Wiki entry for WDR24 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR24 Gene

Genomics for WDR24 Gene

Regulatory Elements for WDR24 Gene

Enhancers for WDR24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G000640 1.4 ENCODE dbSUPER 5.2 +45.1 45094 10.1 MLX CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 SP3 NFYC LOC105371038 IFT140 WFIKKN1 ENSG00000262528 JMJD8 WASH4P RHBDL1 ENSG00000261505 ENSG00000269482 ENSG00000260051
GH16G000693 1.3 Ensembl ENCODE 0.7 -4.2 -4220 3.3 HDGF PKNOX1 CREB3L1 AGO1 SIN3A DMAP1 ZNF2 SLC30A9 ZNF263 SP3 WFIKKN1 LOC105371038 NARFL LOC102724985 WDR24
GH16G000689 1.2 ENCODE 0.7 +0.4 408 1.7 CREB3L1 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 MCM3 WFIKKN1 ENSG00000259840 PRR25 WASIR2 LOC105371038 ENSG00000261659 WDR24
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR24 on UCSC Golden Path with GeneCards custom track

Promoters for WDR24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082226 249 801 CREB3L1 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 ZFP41

Genomic Location for WDR24 Gene

Chromosome:
16
Start:
684,622 bp from pter
End:
690,649 bp from pter
Size:
6,028 bases
Orientation:
Minus strand

Genomic View for WDR24 Gene

Genes around WDR24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR24 Gene

Proteins for WDR24 Gene

  • Protein details for WDR24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S15-WDR24_HUMAN
    Recommended name:
    WD repeat-containing protein 24
    Protein Accession:
    Q96S15
    Secondary Accessions:
    • A2IDB8
    • D3DU59
    • Q96GC7
    • Q9H0B7

    Protein attributes for WDR24 Gene

    Size:
    920 amino acids
    Molecular mass:
    101989 Da
    Quaternary structure:
    • Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers (PubMed:23723238). The GATOR2 complex interacts with GATSL2 and GATSL3; the interaction is negatively regulated by arginine (PubMed:26972053). The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids (PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26586190).

    Alternative splice isoforms for WDR24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR24 Gene

Post-translational modifications for WDR24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR24 Gene

Domains & Families for WDR24 Gene

Gene Families for WDR24 Gene

Protein Domains for WDR24 Gene

Suggested Antigen Peptide Sequences for WDR24 Gene

Graphical View of Domain Structure for InterPro Entry

Q96S15

UniProtKB/Swiss-Prot:

WDR24_HUMAN :
  • Belongs to the WD repeat WDR24 family.
Family:
  • Belongs to the WD repeat WDR24 family.
genes like me logo Genes that share domains with WDR24: view

Function for WDR24 Gene

Molecular function for WDR24 Gene

UniProtKB/Swiss-Prot Function:
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).

Gene Ontology (GO) - Molecular Function for WDR24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with WDR24: view

Phenotypes for WDR24 Gene

genes like me logo Genes that share phenotypes with WDR24: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WDR24

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR24 Gene

Localization for WDR24 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR24 gene
Compartment Confidence
lysosome 5
mitochondrion 2
cytosol 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for WDR24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 28199306
GO:0061700 GATOR2 complex IDA 23723238
genes like me logo Genes that share ontologies with WDR24: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDR24 Gene

Pathways & Interactions for WDR24 Gene

SuperPathways for WDR24 Gene

SuperPathway Contained pathways
1 mTOR signaling pathway (KEGG)
genes like me logo Genes that share pathways with WDR24: view

Pathways by source for WDR24 Gene

1 KEGG pathway for WDR24 Gene

Gene Ontology (GO) - Biological Process for WDR24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0010506 regulation of autophagy IMP 27166823
GO:0032008 positive regulation of TOR signaling IMP 23723238
GO:0034198 cellular response to amino acid starvation IMP 23723238
genes like me logo Genes that share ontologies with WDR24: view

No data available for SIGNOR curated interactions for WDR24 Gene

Drugs & Compounds for WDR24 Gene

No Compound Related Data Available

Transcripts for WDR24 Gene

Unigene Clusters for WDR24 Gene

WD repeat domain 24:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WDR24

Alternative Splicing Database (ASD) splice patterns (SP) for WDR24 Gene

No ASD Table

Relevant External Links for WDR24 Gene

GeneLoc Exon Structure for
WDR24
ECgene alternative splicing isoforms for
WDR24

Expression for WDR24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR24 Gene

Protein differential expression in normal tissues from HIPED for WDR24 Gene

This gene is overexpressed in Placenta (13.9), Plasma (13.3), Blymphocyte (10.1), Pancreas (9.7), CD8 Tcells (6.3), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR24 Gene



Protein tissue co-expression partners for WDR24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR24 Gene:

WDR24

SOURCE GeneReport for Unigene cluster for WDR24 Gene:

Hs.459632

Evidence on tissue expression from TISSUES for WDR24 Gene

  • Kidney(4.1)
  • Liver(4.1)
  • Lung(4.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with WDR24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR24 Gene

Orthologs for WDR24 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR24 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR24 34 35
  • 89.7 (n)
dog
(Canis familiaris)
Mammalia WDR24 34 35
  • 88.91 (n)
rat
(Rattus norvegicus)
Mammalia Wdr24 34
  • 87 (n)
mouse
(Mus musculus)
Mammalia Wdr24 34 16 35
  • 86.37 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR24 35
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR24 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR24 34 35
  • 82.05 (n)
lizard
(Anolis carolinensis)
Reptilia WDR24 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr24 34
  • 74.31 (n)
African clawed frog
(Xenopus laevis)
Amphibia mgc47001-prov 34
zebrafish
(Danio rerio)
Actinopterygii wdr24 34 35
  • 72.75 (n)
Dr.5400 34
fruit fly
(Drosophila melanogaster)
Insecta CG7609 34 35
  • 51.25 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001159 34
  • 50.14 (n)
worm
(Caenorhabditis elegans)
Secernentea Y32H12A.8 35
  • 3 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTC5 35
  • 10 (a)
OneToMany
RTC1 37
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC4F8.11 34
  • 36.72 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToOne
Species where no ortholog for WDR24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR24 Gene

ENSEMBL:
Gene Tree for WDR24 (if available)
TreeFam:
Gene Tree for WDR24 (if available)

Paralogs for WDR24 Gene

Paralogs for WDR24 Gene

genes like me logo Genes that share paralogs with WDR24: view

Variants for WDR24 Gene

Sequence variations from dbSNP and Humsavar for WDR24 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000709095 -- 688,058(+) GAGAA(C/T)AGGAA intron-variant, reference, missense
rs1001041321 -- 692,495(+) CTCAG(A/G)CACAT downstream-variant-500B, upstream-variant-2KB
rs1001145224 -- 691,073(+) CTGGG(C/T)CCGTC upstream-variant-2KB
rs1001194178 -- 684,298(+) CGCGA(C/G)CAACC intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense
rs1001333493 -- 690,549(+) CTGCG(G/T)GCCGC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for WDR24 Gene

Variant ID Type Subtype PubMed ID
dgv454n67 CNV gain 20364138
dgv4825n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv457311 CNV loss 19166990
nsv471063 CNV loss 18288195
nsv471065 CNV gain 18288195
nsv482183 CNV gain 20164927
nsv516590 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571012 CNV loss 21841781
nsv827480 CNV gain 20364138
nsv827482 CNV loss 20364138
nsv9321 CNV gain+loss 18304495
nsv952898 CNV deletion 24416366

Variation tolerance for WDR24 Gene

Residual Variation Intolerance Score: 7.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.13; 84.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR24 Gene

Disorders for WDR24 Gene

Relevant External Links for WDR24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR24

No disorders were found for WDR24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR24 Gene

Publications for WDR24 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. The CASTOR proteins are arginine sensors for the mTORC1 pathway. (PMID: 26972053) Chantranupong L. … Sabatini D.M. (Cell 2016) 3 4 64
  3. The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function. (PMID: 27166823) Cai W. … Lilly M.A. (PLoS Genet. 2016) 3 4 64
  4. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. (PMID: 23723238) Bar-Peled L. … Sabatini D.M. (Science 2013) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for WDR24 Gene

  • Addgene plasmids for WDR24

Sources for WDR24 Gene

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