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Aliases for WDR24 Gene

Aliases for WDR24 Gene

  • WD Repeat Domain 24 2 3
  • C16orf21 3 4
  • Chromosome 16 Open Reading Frame 21 2
  • WD Repeat-Containing Protein 24 3
  • JFP7 3

External Ids for WDR24 Gene

Previous HGNC Symbols for WDR24 Gene

  • C16orf21

Previous GeneCards Identifiers for WDR24 Gene

  • GC00U911617
  • GC16M000675
  • GC16M000677
  • GC16M000734
  • GC16M000656

Summaries for WDR24 Gene

GeneCards Summary for WDR24 Gene

WDR24 (WD Repeat Domain 24) is a Protein Coding gene. An important paralog of this gene is WDR59.

UniProtKB/Swiss-Prot for WDR24 Gene

  • As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway

Gene Wiki entry for WDR24 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR24 Gene

Genomics for WDR24 Gene

Regulatory Elements for WDR24 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WDR24 Gene

684,622 bp from pter
690,444 bp from pter
5,823 bases
Minus strand

Genomic View for WDR24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR24 Gene

Proteins for WDR24 Gene

  • Protein details for WDR24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 24
    Protein Accession:
    Secondary Accessions:
    • A2IDB8
    • D3DU59
    • Q96GC7
    • Q9H0B7

    Protein attributes for WDR24 Gene

    920 amino acids
    Molecular mass:
    101989 Da
    Quaternary structure:
    • Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers.

    Alternative splice isoforms for WDR24 Gene


neXtProt entry for WDR24 Gene

Proteomics data for WDR24 Gene at MOPED

Post-translational modifications for WDR24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR24 Gene

Domains for WDR24 Gene

Gene Families for WDR24 Gene

Protein Domains for WDR24 Gene

Suggested Antigen Peptide Sequences for WDR24 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat WDR24 family.
  • Contains 6 WD repeats.
  • Belongs to the WD repeat WDR24 family.
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR24: view

Function for WDR24 Gene

Molecular function for WDR24 Gene

UniProtKB/Swiss-Prot Function:
As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway

Gene Ontology (GO) - Molecular Function for WDR24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with WDR24: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR24

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR24 Gene

Localization for WDR24 Gene

Subcellular locations from

Jensen Localization Image for WDR24 Gene COMPARTMENTS Subcellular localization image for WDR24 gene
Compartment Confidence
cytosol 2
mitochondrion 2
peroxisome 2
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR24 Gene

Pathways for WDR24 Gene

SuperPathways for WDR24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR24 Gene


No data available for Pathways by source for WDR24 Gene

Transcripts for WDR24 Gene

mRNA/cDNA for WDR24 Gene

Unigene Clusters for WDR24 Gene

WD repeat domain 24:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR24

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR24 Gene

No ASD Table

Relevant External Links for WDR24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR24 Gene

mRNA expression in normal human tissues for WDR24 Gene

Protein differential expression in normal tissues for WDR24 Gene

This gene is overexpressed in Placenta (13.9), Plasma (13.3), Blymphocyte (10.1), Pancreas (9.7), CD8 Tcells (6.3), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR24 Gene

SOURCE GeneReport for Unigene cluster for WDR24 Gene Hs.459632

genes like me logo Genes that share expressions with WDR24: view

Expression partners for WDR24 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR24 Gene

Orthologs for WDR24 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR24 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR24 35
  • 89.7 (n)
  • 95.82 (a)
WDR24 36
  • 96 (a)
(Canis familiaris)
Mammalia WDR24 35
  • 88.91 (n)
  • 94.77 (a)
WDR24 36
  • 86 (a)
(Mus musculus)
Mammalia Wdr24 35
  • 86.37 (n)
  • 95.57 (a)
Wdr24 16
Wdr24 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Wdr24 35
  • 87 (n)
  • 96.46 (a)
(Monodelphis domestica)
Mammalia WDR24 36
  • 86 (a)
(Pan troglodytes)
Mammalia WDR24 36
  • 79 (a)
(Gallus gallus)
Aves WDR24 35
  • 82.05 (n)
  • 81.96 (a)
WDR24 36
  • 82 (a)
(Anolis carolinensis)
Reptilia WDR24 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr24 35
  • 74.31 (n)
  • 80.67 (a)
African clawed frog
(Xenopus laevis)
Amphibia mgc47001-prov 35
(Danio rerio)
Actinopterygii Dr.5400 35
wdr24 35
  • 72.75 (n)
  • 72.8 (a)
wdr24 36
  • 71 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001159 35
  • 50.14 (n)
  • 42.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7609 35
  • 51.25 (n)
  • 40.27 (a)
CG7609 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea Y32H12A.8 36
  • 3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTC5 36
  • 10 (a)
RTC1 38
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC4F8.11 35
  • 36.72 (n)
  • 28.69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for WDR24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR24 Gene

Gene Tree for WDR24 (if available)
Gene Tree for WDR24 (if available)

Paralogs for WDR24 Gene

Paralogs for WDR24 Gene

genes like me logo Genes that share paralogs with WDR24: view

Variants for WDR24 Gene

Sequence variations from dbSNP and Humsavar for WDR24 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1018804 -- 687,793(-) GAGGG(C/T)GCACC intron-variant
rs4984682 -- 690,404(+) GCTGT(C/G)TTTCC upstream-variant-2KB
rs4984913 -- 690,466(+) GCACA(A/G)ACTCT upstream-variant-2KB
rs6600230 -- 688,477(+) TTAGT(A/G)GATAT intron-variant
rs8044597 -- 690,881(+) TGGGA(A/T)TGCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WDR24 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904707 CNV Loss 21882294
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
dgv2479n71 CNV Loss 21882294
nsv471063 CNV Loss 18288195
dgv2485n71 CNV Loss 21882294
nsv904759 CNV Loss 21882294
dgv2487n71 CNV Loss 21882294
nsv516590 CNV Loss 19592680
dgv2488n71 CNV Loss 21882294
nsv904781 CNV Gain 21882294
nsv471065 CNV Gain 18288195
nsv904785 CNV Gain+Loss 21882294
dgv2490n71 CNV Loss 21882294
nsv9321 CNV Gain+Loss 18304495
dgv2491n71 CNV Loss 21882294
nsv904796 CNV Loss 21882294
nsv904797 CNV Loss 21882294
dgv2492n71 CNV Loss 21882294
nsv904799 CNV Loss 21882294
nsv827480 CNV Gain 20364138
dgv2493n71 CNV Loss 21882294
dgv2494n71 CNV Loss 21882294
nsv457311 CNV Loss 19166990
nsv482183 CNV Gain 20164927
nsv827482 CNV Loss 20364138
dgv454n67 CNV Gain 20364138

Relevant External Links for WDR24 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR24 Gene

Disorders for WDR24 Gene

No disorders were found for WDR24 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for WDR24 Gene

Publications for WDR24 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for WDR24 Gene

  • Addgene plasmids for WDR24

Sources for WDR24 Gene

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