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WDR23 Gene

protein-coding   GIFtS: 46

GC14P023653
WD repeat domain 23
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZp779A1629 2
GL014 1, 2
OTTHUMP00000164696 2
PRO2389 1, 2
Descriptions
WD repeat domain 23 2
External Ids
HGNC: 202581
Entrez Gene: 803442
UniProtKB: Q8TEB13
Ensembl: ENSG000001008977
Search outside databases for aliases for WDR23 gene

Previous GC identifers: GC14P018371 GC14P022574

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for WDR23:
This gene encodes a WD repeat-containing protein. Multiple alternatively spliced transcript
variants have been found for this gene, but the full-length nature of some variants has not been
defined. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WDR23 gene  

Entrez Gene cytogenetic band: 14q12   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q11.2

WDR23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P023653:     (about GC identifiers)

Start:
23,653,861 bp from pter
End:
23,664,291 bp from pter
Size:
10,431 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000014.7  NT_026437.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WDR23_HUMAN, Q8TEB1 (See protein sequence)
Recommended Name: WD repeat-containing protein 23  
Size: 546 amino acids; 61670 Da
Sequence caution: Sequence=AAG44727.1; Type=Frameshift; Positions=514, 516, 519, 535;
Secondary accessions: B3KQ83 Q5D039 Q86U00 Q86U39 Q8NDN2 Q9H2J0 Q9H3A3 Q9H5C9
Alternative splicing: 3 isoforms:  Q8TEB1-1   Q8TEB1-2   Q8TEB1-3   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_079506.3  NP_852002.1  


    ENSEMBL proteins: 
    ENSP00000323680 ENSP00000380142 ENSP00000335410 ENSP00000380146 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (WDR23)
    Human Recombinant Proteins from Abnova (WDR23)
                   OriGene Purified Recombinant Human Proteins (see all 2): WDR23  


    Antibodies for WDR23: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (WDR23), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for WDR23

    Assays for WDR23: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/7 InterPro domains/families (see all 7 ):
     IPR019782 WD40_repeat_2
     IPR019775 WD40_repeat_CS
     IPR017399 WD_repeat_p23
     IPR019781 WD40_repeat_sg
     IPR001680 WD40_repeat


       GeneDecks  WDR23 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q8TEB1

    ProtoNet protein and cluster: Q8TEB1

    UniProtKB/Swiss-Prot: WDR23_HUMAN, Q8TEB1
    Similarity: Contains 7 WD repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WDR23)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_025230

                  Applied Biosystems Silencer® siRNAs for WDR23

                  Sigma-Aldrich siRNA for WDR23  
                         Sigma-Aldrich shRNA for WDR23  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for WDR23
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_025230
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_025230
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_025230 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_025230

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    1 Interacting protein for WDR23 (Q8TEB11) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDB1Q165311EBI-2213388, EBI-350322
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for WDR23

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WDR23)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_025230

                  Sigma-Aldrich siRNA for WDR23  
                         Sigma-Aldrich shRNA for WDR23  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_025230  NM_181357  

    REFSEQ mRNAs for WDR23 gene (2 alternative transcripts): 

    NM_025230.3   NM_181357.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_025230  NM_181357  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_025230
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_025230
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_025230 

    Additional cDNA sequence: 

    AB209073.1 AF130070.1 AF267858.1 AF283773.2 AK027223.1 AK057636.1 AK074296.1 AK094478.1 
    AK292797.1 AK296742.1 AK307849.1 AL833831.1 BC008858.2 BC067132.1 BX161405.1 BX247970.1 
    BX648224.1 CR591345.1 CR591826.1 CR593514.1 CR608759.1 CR611586.1 CR612369.1 CR614614.1 
    CR616798.1 

    24/42 DOTS entries (see all 42 ):

    DT.100800736  DT.100803170  DT.312352  DT.117168  DT.92410643  DT.100866229  DT.92464285  DT.100866231 
    DT.100866220  DT.92464288  DT.120792065  DT.91850921  DT.100866221  DT.95361584  DT.95320451  DT.100775953 
    DT.91860627  DT.100866236  DT.120792296  DT.120792127  DT.100769101  DT.120792179  DT.120792297  DT.95361582 

    24/382 AceView cDNA sequences (see all 382 ):

    BQ574746 BU176358 BM716221 BG828935 CR612369 AU130368 AL602608 BM474209 
    NM_203402 BU167583 BU173185 BX161405 BX463696 BM846447 CR614614 BG403808 
    BU188056 BP346446 AI301190 AW003607 AA332097 AU142106 AK074296 CB994436 

    highest scoring ESTs for WDR23:

    AW006674 AA112485 AA225567 AA225654 AA311169 AA323418 AA334230 AA348966 AA384311 AA554543 

    Unigene Cluster for WDR23:

    WD repeat domain 23
    Hs.525251  [show with all ESTs]
    Unigene Representative Sequence: NM_025230


    GeneLoc Exon Structure

    5/25 Alternative Splicing Database (ASD) splice patterns (SP) for WDR23 (see all 25 )

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ·
    SP1:                    -     -     -     -     -     -     -     -     -                                                                                       
    SP2:                                                  -     -                                                                                                   
    SP3:                                                                    -           -     -                                                                     
    SP4:                                                                                -                                                                           
    SP5:                    -     -     -     -     -     -     -     -                 -                                                                           

    ExUns: 9d ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:              -                 -                                             
    SP2:              -                 -                                             
    SP3:              -                 -                                             
    SP4:              -                 -                                             
    SP5:                                                                              

    About this scheme

    ECgene alternative splicing isoforms for WDR23

    4 Ensembl transcripts including schematic representations:
    ENST00000326009  ENST00000396936  ENST00000334688  ENST00000396941  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    WDR23 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for WDR23

    1 / 2 / 3

    7 probe-sets matching WDR23 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    58753_at2, 3 U95-C 1 1.00 1.00 0.84 1.26 AW006674 1.00 0.90 0.95 1

    38449_at2, 3 U95-A 1 1.00 1.00 0.63 1.15 W28931 0.80 0.88 0.84 1
    86292_at2, 3 U95-D 1 0.31 1.00 0.66 0.60 AI248656 0.60 0.83 0.73 1

    216389_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF283773 0.40 0.75 0.60 1

    201886_at2, 3 U133-A 1 1.00 1.00 -- -- NM_025230 0.60 0.83 0.73 1

    216389_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    201886_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  WDR23 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CTGGAGGCAC

    SOURCE GeneReport for Unigene cluster: Hs.525251

    Expression variation in blood from EXPOLDB for WDR23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for WDR23 gene from 5/12 species (see all 12 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    WDR231   -- WD repeat domain 23 92.74(n)
    95.79(a)
    490621  XM_547743.2  XP_547743.2 
    chimpanzee
    (Pan troglodytes)
    WDR231   -- WD repeat domain 23 99.6(n)
    100(a)
    452808  XM_509863.2  XP_509863.2 
    cow
    (Bos taurus)
    WDR231   -- WD repeat domain 23 92.19(n)
    94.87(a)
    539433  NM_001014954.1  NP_001014954.1 
    rat
    (Rattus norvegicus)
    Wdr231   -- WD repeat domain 23 89.99(n)
    94.32(a)
    305895  NM_001009686.2  NP_001009686.1 
    mouse
    (Mus musculus)
    Wdr231, 5 14 (24.50 cM)5
    WD repeat domain 231, 5 89.62(n)1
    93.77(a)1
    281991  NM_133734.21  NP_598495.11 
     AI8362725  AK0030285  (see all 19)
    About this table        Species with no ortholog for WDR23

    ENSEMBL Gene Tree for WDR23
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/50 NCBI SNPs in WDR23 are shown (see all 50 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 36)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs65735651,2
    A,C,F,H23664573(+) TCGAAA/GTAATG 2 -- ng318Minor allele frequency- G:0.46EU EA WA 838
    rs118483861,2
    C,F,H23654103(+) TTAGGC/ACAAAT 2 -- ut514Minor allele frequency- A:0.03EU EA WA 418
    rs38255831,2
    C,F,H23653686(+) CCACTT/AACTCC 2 -- ng514Minor allele frequency- A:0.17EA MN EU 1970
    rs38255841,2
    C,F,H23657479(+) TTTCCG/ATAAAT 2 H/R mis1 ese310Minor allele frequency- A:0.39EA EU WA NA 2418
    rs171013921,2
    F,H23663254(+) TGAGCC/GTTGCA 2 -- ut317Minor allele frequency- G:0.05NA EU EA WA 506
    --
    rs80095111,2
    A,C23663820(+) gcacgA/Gtggtt 2 -- ut31 ese30--------
    --
    rs11343401,2
    C,F23664053(+) caagaC/Tcatgc 2 -- ut311Minor allele frequency- T:0.32MN 184
    rs38111751,2
    C,F23653304(+) TGTCTT/AAAAAA 2 -- ng512Minor allele frequency- A:0.15MN EA 356
    rs101380061,2
    F,H23653008(+) CGTCCC/TCACCC 2 -- ng514Minor allele frequency- T:0.02EU EA WA 418
    rs171013471,2
    F,H23653952(+) TGCGGG/TTCCTG 2 -- ut51 ese37Minor allele frequency- T:0.03NA EU EA WA 558
    About this table

    HapMap Linkage Disequilibrium images for WDR23 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    6 PubMed articles for WDR23 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 80344 HGNC: 20258 AceView: WDR23 Ensembl:ENSG00000100897 euGenes: HUgn80344
    ECgene: WDR23 H-InvDB: WDR23
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for WDR23:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for WDR23-related products

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     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for WDR23 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for WDR23 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     shRNA in GFP-retroviral vector
     Search Tocris compounds for WDR23




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for WDR23

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