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WDR22 Gene

protein-coding GIFtS: 49

GC14M068587

WD repeat domain 22
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BCRG2 ^¹, ², ³
BCRP2 ^¹, ², ³, ⁵
D14S1461E ^¹, ², ⁵
DKFZp434A035 ^²
KIAA1824 ^¹, ², ³

Descriptions
Breakpoint cluster region protein 2 ^³
Breakpoint cluster region protein, uterine leiomyoma, 2 ^²
WD repeat domain 22 ^²

External Ids
HGNC: 20224¹
Entrez Gene: 8816²
UniProtKB: Q96JK2³
Ensembl: ENSG00000139990⁷

Search outside databases for aliases for WDR22 gene

Previous GC identifers: GC14M063314 GC14M067507 GC14M067510

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the WDR22 gene

Entrez Gene cytogenetic band: 14q23-q24.1 Ensembl cytogenetic band: 14q24.1 HGNC cytogenetic band: 14q23-q24.1

WDR22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M068587: (about GC identifiers)

Start:	68,587,395 bp from pter
End:	68,689,502 bp from pter
Size:	102,108 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WDR22_HUMAN, Q96JK2 (See protein sequence)

Recommended Name: WD repeat-containing protein 22

Size: 942 amino acids; 103963 Da

Sequence caution: Sequence=AAC08965.1; Type=Frameshift; Positions=772, 809, 812, 817, 836, 844,

858;

Secondary accessions: O60559 Q8N3V3 Q8N3V5

Alternative splicing: 2 isoforms: Q96JK2-1 Q96JK2-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003852.1

ENSEMBL proteins:

ENSP00000374647 ENSP00000341351

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (WDR22)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for WDR22:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for WDR22

Assays for WDR22:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q96JK2

ProtoNet protein and cluster: Q96JK2

UniProtKB/Swiss-Prot: WDR22_HUMAN, Q96JK2

Similarity: Contains 6 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR22)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): XM_031102

Applied Biosystems Silencer® siRNAs for WDR22

Sigma-Aldrich siRNA for WDR22

Sigma-Aldrich shRNA for WDR22

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for WDR22
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003861
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003861
untagged cDNA clones in CMV expression vector (see all 3): AK094283

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003861

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for WDR22 (ENSP00000341351³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BCR	ENSP00000303507³	STRING (score=.746)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR22

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR22)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): XM_031102

Sigma-Aldrich siRNA for WDR22

Sigma-Aldrich shRNA for WDR22

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003861

REFSEQ mRNAs for WDR22 gene:

NM_003861.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003861

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003861
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003861
                                 untagged cDNA clones in CMV expression vector (see all 3): AK094283

Additional cDNA sequence:

AB058727.1 AF044774.1 AK054692.1 AL831823.2 AL831932.2 AL834533.1 BC013239.1 BC022967.1

BC136632.1 BC150267.1 BX648006.1 CR619376.1

12 DOTS entries:

DT.100793231 DT.75179506 DT.97859514 DT.100036705 DT.97859513 DT.97859515 DT.91750632 DT.95216048

DT.95243666 DT.86859047 DT.95249714 DT.100033425

24/320 AceView cDNA sequences (see all 320 ):

BQ286050 AA937763 CA391585 AI215512 BM727892 CB178735 AK054692 AI932741

BX099380 AI192848 AA902420 AI568478 BM354102 CB120315 BQ549639 BG501907

CA450073 BM666190 BM725882 AL834533 AA160107 CD515141 AA860264 AI500508

highest scoring ESTs for WDR22:

AI431597 AI568478 AL079838 AA810633 AA828468 AA835848 AA883252 AB058727 AI476440 AW295499

Unigene Cluster for WDR22:

WD repeat domain 22

Hs.509780 [show with all ESTs]

Unigene Representative Sequence: NM_003861

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for WDR22

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7	^	8
SP1:					-						-		-
SP2:					-						-		-
SP3:
SP4:			-		-
SP5:					-

About this scheme

ECgene alternative splicing isoforms for WDR22

2 Ensembl transcripts including schematic representations:

ENST00000389997 ENST00000341516

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR22 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for WDR22

¹ / ² / ³

13 probe-sets matching WDR22 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
43962_at²^{, 3}	U95-B	1	1.00	1.00	0.71	1.12	AI431597	0.80	1.00	0.91	1
62461_at²^{, 3}	U95-C	1	1.00	1.00	0.51	1.09	AI568478	0.80	1.00	0.91	1
85361_at²^{, 3}	U95-D	1	1.00	1.00	0.75	0.94	AI493336	0.40	1.00	0.76	1
56454_at²^{, 3}	U95-B	1	1.00	1.00	0.65	0.88	AL079838	0.80	1.00	0.91	1
224703_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI814644	0.60	1.00	0.82	1
227251_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI431597	0.80	1.00	0.91	1
224696_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI568478	0.80	1.00	0.91	1
224697_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI568478	0.80	1.00	0.91	1
224703_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227251_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224696_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224697_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554558_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks WDR22 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATAAATACAA

SOURCE GeneReport for Unigene cluster: Hs.509780
UniProtKB/Swiss-Prot: WDR22_HUMAN, Q96JK2
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WDR22 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WDR22¹	--	WD repeat domain 22	91.28(n) 94.07(a)	490749 XM_547871.2 XP_547871.2
chimpanzee (Pan troglodytes)	WDR22¹	--	WD repeat domain 22	99.65(n) 99.79(a)	452994 XM_510028.2 XP_510028.2
cow (Bos taurus)	WDR22¹	--	WD repeat domain 22	90.24(n) 93.23(a)	785849 XM_001253727.1 XP_001253728.1
rat (Rattus norvegicus)	Wdr22¹	--	WD repeat domain 22	89.8(n) 92.24(a)	314273 XM_234345.4 XP_234345.3
mouse (Mus musculus)	Wdr22^{1, 5}	12⁵	WD repeat domain 22^{1, 5}	89.05(n)¹ 91.39(a)¹	320808¹ NM_177267.3¹ NP_796241.3¹ AI325023⁵ AI427904⁵ (see all 23)

About this table Species with no ortholog for WDR22

ENSEMBL Gene Tree for WDR22

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for WDR22 gene

WDR42A² WDR42B² WDTC1² IQWD1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/475 NCBI SNPs in WDR22 are shown (see all 475 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 133)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs10135971^1,2	A,C,F,H	68587247(+)	`GTCATA/GGATGT`	1	--	ng5¹		12		EU EA WA NA	1194
	rs1275420^1,2	A,C,F,H	68690673(+)	`GTATTA/GTAGTA`	1	--	ng3¹		7		MN EU EA WA NA	778
	rs10135643^1,2	C,F,H	68587159(+)	`GGAGAC/ACAAAT`	1	--	ng5¹		6		EU EA WA NA	600
	rs17106714^1,2	C,F,H	68587751(+)	`TATCTA/GTTATG`	1	--	ut3¹		15		NA EU EA WA	1382
	rs4899282^1,2	H	68690635(+)	`GAATTC/TTACCA`	1	--	ng3¹		4		EU EA WA	418
--	rs3832973^1,2	C	68590117(+)	`TTCCC-/CTTTCT`	1	--	ut3¹		0	--	--	--	--
	rs7158165^1,2	H	68587950(+)	`TGGGGC/ACTATC`	1	--	ut3¹		4		EU EA WA	418
	rs10134594^1,2	C,F,H	68591815(+)	`CCAGCG/ATGCAG`	1	H/H	syn¹ ese³		4		EU EA WA	418
	rs1710990^1,2	A,C,F,H,O	68644807(+)	`ATGACG/ATGAAC`	1	--	int¹		7		EU EA WA NA	556
	rs2014607^1,2	A,C,F,H,O	68659411(-)	`ATAACA/CACCAA`	1	--	int¹		7		NA EA EU WA	670

About this table

HapMap Linkage Disequilibrium images for WDR22 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603812

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for WDR22 gene:

Genomic and functional map of the chromosome 14 t(12;14) breakpoint cluster region in uterine leiomyoma. (PubMed id 9740667)^{2, 3, 4} Lynch R.A.... Menon A.G. (1998)
Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)^{3, 4} Nagase T....Ohara O. (2001)
A high-resolution metric HAPPY map of human chromosome 14. (PubMed id 9521877)^{2, 3} Dear P.H....Piper M.B. (1998)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8816	HGNC: 20224	AceView: WDR22	Ensembl:ENSG00000139990	euGenes: HUgn8816
ECgene: WDR22	H-InvDB: WDR22

(According to HUGE)
About This Section

HUGE: KIAA1824

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for WDR22	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for WDR22
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for WDR22:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for WDR22-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for WDR22		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for WDR22		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (WDR22)
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	Custom Service for Rabbit Pab from Full-length Protein

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for WDR22

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WDR22 Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for WDR22

Summaries
for WDR22

Genomic Location
for WDR22

Proteins
for WDR22

Protein Domains/
Families
for WDR22

Gene Function
for WDR22

Pathways & Interactions
for WDR22

Drugs & Compounds
for WDR22

Transcripts
for WDR22

Expression
for WDR22

Orthologs
for WDR22

Paralogs
for WDR22

SNPs/Variants
for WDR22

Disorders & Mutations
for WDR22

Medical News
for WDR22

Publications
for WDR22

Search for WDR22

Genome Databases showing WDR22

Other Databases showing WDR22

Specialized Databases showing WDR22

Licensable Technologies
for WDR22

Services
for WDR22

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WDR22 Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor WDR22

Summariesfor WDR22

Genomic Locationfor WDR22

Proteinsfor WDR22

Protein Domains/Familiesfor WDR22

Gene Functionfor WDR22

Pathways & Interactionsfor WDR22

Drugs & Compoundsfor WDR22

Transcriptsfor WDR22

Expression for WDR22

Orthologsfor WDR22

Paralogsfor WDR22

SNPs/Variantsfor WDR22

Disorders & Mutationsfor WDR22

Medical Newsfor WDR22

Publicationsfor WDR22

Search for WDR22

Genome Databases showing WDR22

Other Databases showing WDR22

Specialized Databases showing WDR22

Licensable Technologiesfor WDR22

Servicesfor WDR22

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for WDR22

Summaries
for WDR22

Genomic Location
for WDR22

Proteins
for WDR22

Protein Domains/
Families
for WDR22

Gene Function
for WDR22

Pathways & Interactions
for WDR22

Drugs & Compounds
for WDR22

Transcripts
for WDR22

Expression
for WDR22

Orthologs
for WDR22

Paralogs
for WDR22

SNPs/Variants
for WDR22

Disorders & Mutations
for WDR22

Medical News
for WDR22

Publications
for WDR22

Licensable Technologies
for WDR22

Services
for WDR22