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WDR21C Gene

protein-coding   GIFtS: 40

GC08M088953
WD repeat domain 21C
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ35775 2
MGC133227 2
Descriptions
WD repeat domain 21C 2
External Ids
HGNC: 266571
Entrez Gene: 1380092
UniProtKB: Q8NA753
Ensembl: ENSG000001765667
Search outside databases for aliases for WDR21C gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WDR21C gene  

Entrez Gene cytogenetic band: 8q21.3   Ensembl cytogenetic band:  8q21.3   HGNC cytogenetic band: 8q21.3

WDR21C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M088953:     (about GC identifiers)

Start:
88,952,095 bp from pter
End:
88,955,412 bp from pter
Size:
3,318 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000008.9  NT_008046.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WD21C_HUMAN, Q8NA75 (See protein sequence)
Recommended Name: WD repeat-containing protein 21C  
Size: 395 amino acids; 43747 Da

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_689631.1  

    ENSEMBL proteins: 
    ENSP00000316496 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (WDR21C)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for WDR21C: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for WDR21C

    Assays for WDR21C: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR019782 WD40_repeat_2
     IPR019775 WD40_repeat_CS
     IPR019781 WD40_repeat_sg
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_region


       GeneDecks  WDR21C for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q8NA75

    ProtoNet protein and cluster: Q8NA75

    UniProtKB/Swiss-Prot: WD21C_HUMAN, Q8NA75
    Similarity: Contains 2 WD repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WDR21C)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152418

                  Applied Biosystems Silencer® siRNAs for WDR21C

                  Sigma-Aldrich siRNA for WDR21C  
                         Sigma-Aldrich shRNA for WDR21C  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_152418
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_152418
                                     untagged cDNA clone in CMV expression vector: NM_152418 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_152418

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for WDR21C

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WDR21C)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152418

                  Sigma-Aldrich siRNA for WDR21C  
                         Sigma-Aldrich shRNA for WDR21C  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_152418  

    REFSEQ mRNAs for WDR21C gene: 

    NM_152418.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_152418  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_152418
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_152418
                                     untagged cDNA clone in CMV expression vector: NM_152418 

    Additional cDNA sequence: 

    AK093094.1 AK097600.1 AL833507.1 BC035011.2 BC111778.1 

    1 DOTS entry:

    DT.95312876 

    11 AceView cDNA sequences:

    NM_152418 AK097600 BC035011 AL833507 AA917062 AX747918 AA757369 AK093094 
    BI460595 AW592218 AA583332 

    highest scoring ESTs for WDR21C:

    AA917062 AK093094 AK097600 AL833507 BC035011 BI460595 AA583332 AA757369 AI216416 AW592218 

    Unigene Cluster for WDR21C:

    WD repeat domain 21C
    Hs.371738  [show with all ESTs]
    Unigene Representative Sequence: NM_152418


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000319675  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    WDR21C expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for WDR21C

    1 / 2 / 3

    3 probe-sets matching WDR21C gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    88055_at2, 3 U95-D 1 1.00 1.00 1.00 1.00 AA917062 0.80 1.00 0.91 1

    1553197_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1553199_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTGATTGTAA

    SOURCE GeneReport for Unigene cluster: Hs.371738
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for WDR21C gene from 1 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    WDR21C1   -- WD repeat domain 21C 98.99(n)
    97.72(a)
    472811  XM_528183.2  XP_528183.1 
    About this table        Species with no ortholog for WDR21C

    ENSEMBL Gene Tree for WDR21C
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for WDR21C gene
    WDR21A2  WDR21B2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/13 NCBI SNPs in WDR21C are shown (see all 13 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 7)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 8 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs168742821,2
    C,F,H88952217(+) CCGCAG/CCTAGT 1 -- ut3111Minor allele frequency- C:0.07NA EU EA WA 924
    --
    rs117840271,2
    C88956498(+) caggcA/Gtgagc 1 -- ng310--------
    --
    rs732802581,2
    --88956210(+) TTATTG/TATTGA 1 -- ng310--------
    --
    rs574168521,2
    --88953858(+) AAAAA-/AAAGGGGG 1 -- ut310--------
    --
    rs574576011,2
    --88953860(+) AAAAA-/AGGGGG 1 -- ut310--------
    --
    rs666443991,2
    --88953860(+) AAAAAA/GGGGGG 1 -- ut310--------
    --
    rs566715101,2
    --88952344(+) TTACA-/CAGTTTC 1 -- ut310--------
    --
    rs340413571,2
    --88953861(+) AAAAA-/GGGGGG 1 -- ut310--------
    --
    rs355789611,2
    --88952341(+) AGCTT-/ACACAGT 1 -- ut310--------
    --
    rs132785301,2
    --88956650(+) ctcccC/Gggttc 1 -- ng310--------
    About this table

    HapMap Linkage Disequilibrium images for WDR21C (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    4 PubMed articles for WDR21C gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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    Entrez Gene: 138009 HGNC: 26657 AceView: FLJ35775 Ensembl:ENSG00000176566 euGenes: HUgn138009
    ECgene: WDR21C H-InvDB: WDR21C
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
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      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for WDR21C:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for WDR21C Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for WDR21C Browse small molecules at Sigma-Aldrich
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