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WDR21B Gene

protein-coding   GIFtS: 35

GC04P041678
WD repeat domain 21B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MGC126021 2
MGC126022 2
Descriptions
WD repeat domain 21B 2
External Ids
HGNC: 277231
Entrez Gene: 2854292
UniProtKB: Q3SXM03
Ensembl: ENSG000001823087
Search outside databases for aliases for WDR21B gene

Previous GC identifer: GC00U921651

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p13   Ensembl cytogenetic band:  4p13   HGNC cytogenetic band: 4p13

WDR21B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P041678:     (about GC identifiers)

Start:
41,678,470 bp from pter
End:
41,683,241 bp from pter
Size:
4,772 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000004.10  NT_006238.10  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WD21B_HUMAN, Q3SXM0 (See protein sequence)
Recommended Name: WD repeat-containing protein 21B  
Size: 396 amino acids; 44264 Da
Secondary accessions: Q3ZCW8 Q499Y5 Q9UFI0

REFSEQ proteins: NP_001025126.2  

ENSEMBL proteins: 
ENSP00000327796 


Human Recombinant Proteins 
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Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for WDR21B: 
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for WDR21B

Assays for WDR21B: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro domains/families:
 IPR019782 WD40_repeat_2
 IPR019775 WD40_repeat_CS
 IPR001680 WD40_repeat
 IPR017986 WD40_repeat_region
 IPR015943 WD40/YVTN_repeat-like


   GeneDecks  WDR21B for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q3SXM0

ProtoNet protein and cluster: Q3SXM0

UniProtKB/Swiss-Prot: WD21B_HUMAN, Q3SXM0
Similarity: Contains 2 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (WDR21B)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_209607

              Applied Biosystems Silencer® siRNAs for WDR21B

              Sigma-Aldrich siRNA for WDR21B  
                     Sigma-Aldrich shRNA for WDR21B  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001029955
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001029955
                                 untagged cDNA clone in CMV expression vector: NM_001029955 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001029955

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR21B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (WDR21B)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_209607

              Sigma-Aldrich siRNA for WDR21B  
                     Sigma-Aldrich shRNA for WDR21B  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001029955  

REFSEQ mRNAs for WDR21B gene: 

NM_001029955.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001029955  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001029955
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001029955
                                 untagged cDNA clone in CMV expression vector: NM_001029955 

Additional cDNA sequence: 

AK122914.1 BC035027.1 BC052943.1 BC104224.1 BC104225.1 

2 DOTS entries:

DT.40302320  DT.40230833 

17 AceView cDNA sequences:

AA884411 AL045282 AL045268 BC052943 BC035027 BU561160 AK122914 AW292317 
AI916962 BQ432632 BQ441622 AI825047 AI962648 BI463947 AL122070 BG718392 
CD358409 

highest scoring ESTs for WDR21B:

AA884411 AK122914 AL045268 AL045282 AL122070 BC035027 BC052943 BG718392 BI463947 BU561160 

Unigene Cluster for WDR21B:

WD repeat domain 21B
Hs.213307  [show with all ESTs]
Unigene Representative Sequence: NM_001029955


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000333141  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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WDR21B expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for WDR21B

1 / 2 / 3

2 probe-sets matching WDR21B gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
71258_at2, 3 U95-E 2 1.00 0.97 1.00 1.00 AI916962 0.60 1.00 0.82 1

1562209_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  WDR21B for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CAGTTTATAT

SOURCE GeneReport for Unigene cluster: Hs.213307
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for WDR21B gene from 1 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
WDR21B1   -- WD repeat domain 21B 99.41(n)
99.24(a)
471182  XM_526564.2  XP_526564.1 
About this table        Species with no ortholog for WDR21B

ENSEMBL Gene Tree for WDR21B
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for WDR21B gene
WDR21C2  WDR21A2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/34 NCBI SNPs in WDR21B are shown (see all 34 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 46)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 4 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs26603351,2
A,C,F,H,O41680446(+) CAGCTT/CCGGTT 1 -- ut31 ese34Minor allele frequency- C:0.34EU EA WA 418
rs26603321,2
A,C,F,H,O41679858(+) TGTATG/ATAGAT 1 -- ut31 ese37Minor allele frequency- A:0.35NA EU EA WA 560
rs25814391,2
C,F,H,O41681614(-) AACCAC/TACTCC 1 -- ut3111Minor allele frequency- T:0.19NS EU EA NA 532
rs14669791,2
A,C,F,H41677257(-) gagccG/Taggag 1 -- ng514Minor allele frequency- T:0.28EU EA WA 418
rs25814381,2
A,C,F,H41682649(-) ttctgT/Ccctac 1 -- ut314Minor allele frequency- C:0.26EU EA WA 416
rs26603341,2
C,F,H41680235(+) TTCTCG/AGAGTC 1 -- ut31 ese34Minor allele frequency- A:0.02EU EA WA 420
rs9378661,2
C,F,H41676499(-) AAAAAG/AGGGGT 1 -- ng51 trp37Minor allele frequency- A:0.36NA EU EA WA 548
--
rs14669781,2
A,C41678301(+) ctgtcC/Tcaaaa 1 -- ng510--------
rs25814401,2
H41679333(-) GATTTC/TTACAA 1 R/K mis1 ese34Minor allele frequency- T:0.00EU EA WA 420
rs44105571,2
H41681674(+) TATGTG/AACATG 1 -- ut31 ese34Minor allele frequency- A:0.00EU EA WA 420
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HapMap Linkage Disequilibrium images for WDR21B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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5 PubMed articles for WDR21B gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 285429 HGNC: 27723 AceView: LOC285429 Ensembl:ENSG00000182308 euGenes: HUgn285429
ECgene: WDR21B H-InvDB: WDR21B
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for WDR21B:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for WDR21B-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for WDR21B Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for WDR21B Browse small molecules at Sigma-Aldrich
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