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WDR21A Gene

protein-coding GIFtS: 47

GC14P072463

WD repeat domain 21A
(Previous name: WD repeat domain 21 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: WDR21)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DKFZp434K114 ^¹, ²
MGC20547 ^²
MGC46524 ^²
WDR21 ^², ³

Descriptions
WD repeat domain 21 ^¹
WD repeat domain 21A ^²

External Ids
HGNC: 20229¹
Entrez Gene: 26094²
UniProtKB: Q8WV16³
Ensembl: ENSG00000119599⁷

Search outside databases for aliases for WDR21A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for WDR21A:

This gene encodes a WD repeat-containing protein. Multiple alternatively spliced transcript

variants have been found for this gene, but the full-length nature of some variants has not been

defined. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the WDR21A gene

Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.2 HGNC cytogenetic band: 14q24.3

WDR21A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P072463: (about GC identifiers)

Start:	72,462,838 bp from pter
End:	72,496,110 bp from pter
Size:	33,273 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WD21A_HUMAN, Q8WV16 (See protein sequence)

Recommended Name: WD repeat-containing protein 21A

Size: 495 amino acids; 55694 Da

Secondary accessions: Q86U31 Q96K22 Q9Y4P5

Alternative splicing: 2 isoforms: Q8WV16-1 Q8WV16-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_056419.2 NP_851937.1 NP_851938.1

ENSEMBL proteins:

ENSP00000351147 ENSP00000345176 ENSP00000377781 ENSP00000343567

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (WDR21A)
	Human Recombinant Proteins from Abnova (WDR21A)

OriGene Purified Recombinant Human Protein: WDR21A

Antibodies for WDR21A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (WDR21A), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for WDR21A

Assays for WDR21A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8WV16

ProtoNet protein and cluster: Q8WV16

UniProtKB/Swiss-Prot: WD21A_HUMAN, Q8WV16

Similarity: Contains 2 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR21A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_015604

Applied Biosystems Silencer® siRNAs for WDR21A

Sigma-Aldrich siRNA for WDR21A

Sigma-Aldrich shRNA for WDR21A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for WDR21A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_015604
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_015604
untagged cDNA clones in CMV expression vector (see all 3): NM_015604

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015604

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR21A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR21A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_015604

Sigma-Aldrich siRNA for WDR21A

Sigma-Aldrich shRNA for WDR21A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015604 NM_181340 NM_181341

REFSEQ mRNAs for WDR21A gene (3 alternative transcripts):

NM_015604.2 NM_181340.1 NM_181341.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015604 NM_181340 NM_181341

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_015604
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_015604
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_015604

Additional cDNA sequence:

AK027745.1 AK297571.1 AK297742.1 AK300786.1 AK315499.1 AL080157.1 BC018979.2 BC035901.1

BX161489.1 BX247962.1

11 DOTS entries:

DT.412533 DT.97842484 DT.100791060 DT.100791058 DT.100791056 DT.100791062 DT.120755476 DT.65286008

DT.86859093 DT.91841531 DT.40302320

24/119 AceView cDNA sequences (see all 119 ):

Z41584 BF197939 BM468150 BP351303 BE250235 AW250072 NM_181341 NM_181340

AW438829 BC035901 AI797602 BX247962 NM_015604 BM988680 AW167878 BM824382

BI915515 BM129489 BI963764 BM973774 BM811013 BX283926 AI686444 BX161489

highest scoring ESTs for WDR21A:

AA160604 AA565620 AA903722 AI038805 AI129931 AI686444 AI758097 AI797602 AI923683 AI955081

Unigene Cluster for WDR21A:

WD repeat domain 21A

Hs.331491 [show with all ESTs]

Unigene Representative Sequence: AL080157

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for WDR21A (see all 7 )

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18
SP1:													-		-												-
SP2:					-								-		-												-
SP3:																											-
SP4:											-		-		-		-						-		-		-		-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for WDR21A

4 Ensembl transcripts including schematic representations:

ENST00000358377 ENST00000353777 ENST00000394234 ENST00000340355

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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WDR21A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for WDR21A

¹ / ² / ³

3 probe-sets matching WDR21A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
62494_at²^{, 3}	U95-C	1	1.00	1.00	1.00	1.00	AA160604	1.00	1.00	1.00	1
226938_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA160604	1.00	1.00	1.00	1
226938_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks WDR21A for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTTTGTTCA

SOURCE GeneReport for Unigene cluster: Hs.331491
Expression variation in blood from EXPOLDB for WDR21A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WDR21A gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WDR21A¹	--	WD repeat domain 21A	87.19(n) 88.98(a)	490767 XM_547889.2 XP_547889.2
chimpanzee (Pan troglodytes)	WDR21A¹	--	WD repeat domain 21A	99.53(n) 99.39(a)	467501 XM_001147813.1 XP_001147813.1
cow (Bos taurus)	WDR21A¹	--	WD repeat domain 21A	85.06(n) 82.35(a)	511629 NM_001024520.1 NP_001019691.1
rat (Rattus norvegicus)	Wdr21¹	--	WD repeat domain 21	82.86(n) 81.78(a)	362762 XM_343088.3 XP_343089.3
mouse (Mus musculus)	Wdr21^{1, 5}	12⁵	WD repeat domain 21^{1, 5}	82.93(n)¹ 80.97(a)¹	73828¹ NM_030246.1¹ NP_084522.1¹ AK003772⁵ AK177668⁵ (see all 11)

About this table Species with no ortholog for WDR21A

ENSEMBL Gene Tree for WDR21A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for WDR21A gene

WDR21C² WDR21B²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/281 NCBI SNPs in WDR21A are shown (see all 281 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 102)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7144738^1,2	A,C,F,H	72495434(+)	`CAGGAA/CAGTTA`	3	--	ut3¹		12	EA NA EU WA	1030
	rs2572^1,2	C,F,H,O	72496043(-)	`CTCACG/AAACTG`	3	--	ut3¹ ese³		13	MN NA EU EA WA	1236
	rs7142086^1,2	A,C,F,H	72461346(+)	`cccaaC/Ttctag`	3	--	ng5¹		4	EU EA WA	412
	rs4903081^1,2	A,C,F,H	72496179(+)	`TTTCAT/CAGCCT`	3	--	ng3¹		8	EU EA WA	836
	rs17569391^1,2	C,F,H	72495820(+)	`CAGATC/GTCCGG`	3	--	ut3¹ ese³		15	NA EU EA WA	1398
	rs3213729^1,2	C,F,H	72462999(-)	`CTGTTC/GAGCGT`	3	--	ut5¹		7	EA MN EU WA	3154
	rs2302588^1,2	C,F,H	72474505(-)	`CTGAAC/GCAAGG`	3	W/C	mis¹ int¹		10	EA EU WA NA	2416
	rs3815460^1,2	C,F,H	72492012(+)	`CCGCTC/GTGGGG`	3	S/C	mis¹		9	EU EA WA NA	916
	rs17856582^1,2	C,F,H	72482388(+)	`TGTTAA/CAGTTG`	3	K/T	mis¹		9	EU EA WA NA	890
	rs3815500^1,2	C,F,H	72474433(-)	`TCTGTT/GCCTAA`	3	--	int¹ ut5¹		12	EA NA EU WA	2446

About this table

HapMap Linkage Disequilibrium images for WDR21A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for WDR21A gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 26094	HGNC: 20229	AceView: WDR21	Ensembl:ENSG00000119599	euGenes: HUgn26094
ECgene: WDR21A	H-InvDB: WDR21A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for WDR21A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for WDR21A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for WDR21A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for WDR21A		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for WDR21A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (WDR21A)
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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
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	shRNA in GFP-retroviral vector

Search Tocris compounds for WDR21A

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for WDR21A

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WDR21A Gene

protein-coding GIFtS: 47

Aliases &
Descriptions
for WDR21A

Summaries
for WDR21A

Genomic Location
for WDR21A

Proteins
for WDR21A

Protein Domains/
Families
for WDR21A

Gene Function
for WDR21A

Pathways & Interactions
for WDR21A

Drugs & Compounds
for WDR21A

Transcripts
for WDR21A

Expression
for WDR21A

Orthologs
for WDR21A

Paralogs
for WDR21A

SNPs/Variants
for WDR21A

Disorders & Mutations
for WDR21A

Medical News
for WDR21A

Publications
for WDR21A

Search for WDR21A

Genome Databases showing WDR21A

Other Databases showing WDR21A

Specialized Databases showing WDR21A

Licensable Technologies
for WDR21A

Services
for WDR21A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WDR21A Gene

protein-coding GIFtS: 47

Aliases & Descriptionsfor WDR21A

Summariesfor WDR21A

Genomic Locationfor WDR21A

Proteinsfor WDR21A

Protein Domains/Familiesfor WDR21A

Gene Functionfor WDR21A

Pathways & Interactionsfor WDR21A

Drugs & Compoundsfor WDR21A

Transcriptsfor WDR21A

Expression for WDR21A

Orthologsfor WDR21A

Paralogsfor WDR21A

SNPs/Variantsfor WDR21A

Disorders & Mutationsfor WDR21A

Medical Newsfor WDR21A

Publicationsfor WDR21A

Search for WDR21A

Genome Databases showing WDR21A

Other Databases showing WDR21A

Specialized Databases showing WDR21A

Licensable Technologiesfor WDR21A

Servicesfor WDR21A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for WDR21A

Summaries
for WDR21A

Genomic Location
for WDR21A

Proteins
for WDR21A

Protein Domains/
Families
for WDR21A

Gene Function
for WDR21A

Pathways & Interactions
for WDR21A

Drugs & Compounds
for WDR21A

Transcripts
for WDR21A

Expression
for WDR21A

Orthologs
for WDR21A

Paralogs
for WDR21A

SNPs/Variants
for WDR21A

Disorders & Mutations
for WDR21A

Medical News
for WDR21A

Publications
for WDR21A

Licensable Technologies
for WDR21A

Services
for WDR21A