WDR20 Gene
protein-coding GIFtS: 46
GCID: GC14P102606
|
|
WD repeat domain 20
| |
Aliases for WDR20 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| WD Repeat Domain 201 2 | | DMR1 2 | | FLJ336591 | | MGC331771 | | WD Repeat-Containing Protein 202 | | Protein DMR3 |
Export aliases for WDR20 gene to outside databasesPrevious GC identifers: GC14P096421 GC14P100596 GC14P101675 GC14P082785 |
Summaries for WDR20 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for WDR20: This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene.(provided by RefSeq, Jun 2011)
|
Genomic Views for WDR20 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the WDR20 gene promoter: STAT1 Pbx1a MyoD Egr-4 CREB deltaCREB Pax-4a Ik-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR20
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR20 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.31 Ensembl cytogenetic band: 14q32.31 HGNC cytogenetic band: 14q32.31WDR20 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P102606: view genomic region
(about GC identifiers)
Start:
|
102,605,840 bp from pter |
End:
|
102,691,184 bp from pter |
Size:
|
85,345 bases |
Orientation:
|
plus strand |
|
Proteins for WDR20 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: WDR20_HUMAN, Q8TBZ3 (See
protein sequence)Recommended Name: WD repeat-containing protein 20 Size: 569 amino acids; 62893 Da
Sequence caution: Sequence=AAL56014.1; Type=Erroneous initiation;
Secondary accessions: H0YJJ1 Q86TU2 Q8NCN7 Q8WXX2 Q9UF86Alternative splicing: 4 isoforms: Q8TBZ3-1 Q8TBZ3-2 Q8TBZ3-3 Q8TBZ3-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for WDR20: NX_Q8TBZ3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TBZ3 WDR20 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (8 alternative transcripts):
NP_001229343.1 NP_001229344.1 NP_001229345.1 NP_001229346.1 NP_001229347.1 NP_653175.2 NP_851808.1 NP_851825.1 ENSEMBL proteins: ENSP00000335434 ENSP00000314209 ENSP00000452470 ENSP00000341037 ENSP00000450636 ENSP00000452774 ENSP00000299135 ENSP00000452539 ENSP00000451633 ENSP00000454151 ENSP00000452638 ENSP00000406084 ENSP00000395793 ENSP00000437927 ENSP00000443641 Human Recombinant Protein Products:
WDR20 Antibody Products: Assay Products for WDR20: |
Protein
Domains / Families for WDR20 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR20 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TBZ3ProtoNet protein and cluster: Q8TBZ3 UniProtKB/Swiss-Prot: WDR20_HUMAN, Q8TBZ3Similarity: Contains 5 WD repeats |
Function for WDR20 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR20 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR20 (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): WDR20 (NM_181291) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR20 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR20  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR20 |
|
Pathways & Interactions for WDR20 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR20
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
 5/25 Interacting proteins for WDR20 (Q8TBZ33 ENSP000003354344) via UniProtKB, MINT, STRING, and/or I2D (see all 25)About this table
|
Drugs & Compounds for WDR20 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for WDR20 Search CenterWatch for drugs/clinical trials and news about WDR20 
|
Transcripts for WDR20 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for WDR20 gene (9 alternative transcripts): NM_001242414.1 NM_001242415.1 NM_001242416.1 NM_001242417.1 NM_001242418.1 NM_144574.3 NM_181291.2 NM_181308.2 NM_181302.1 Unigene Cluster for WDR20: WD repeat domain 20 Hs.36859 [show with all ESTs]Unigene Representative Sequence: BX64775118/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22): ENST00000557485 ENST00000335263(uc001yld.3 uc001yle.3) ENST00000322340(uc001ylc.3) ENST00000561154 ENST00000555879 ENST00000342702(uc001ylf.3 uc001ykz.3 uc010txu.2) ENST00000556807 ENST00000558567 ENST00000299135 ENST00000556094 ENST00000556511 ENST00000557186 ENST00000558854 ENST00000559708 ENST00000558135 ENST00000558448 ENST00000555973 ENST00000559478
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR20 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR20 (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): WDR20 (NM_181291) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR20 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR20  |
Additional cDNA sequence: AF327354.1 AK054748.1 AK056330.1 AK090580.1 AK090978.1 AK130824.1 AK225852.1 AK297727.1 AL133558.1 AL832242.1 AL832500.1 BC028387.2 BC030654.2 BX248274.1 BX647751.1 NR_038354.1 24/28 DOTS entries (see all 28): DT.213857 DT.92060722 DT.111888 DT.92416089 DT.91728613 DT.95151401 DT.95274540 DT.101971764 DT.120782022 DT.97843329 DT.100794453 DT.101971236 DT.100794455 DT.92065259 DT.100794451 DT.100794452 DT.120782255 DT.95274539 DT.101972999 DT.120781802 DT.120782001 DT.99969779 DT.99973501 DT.91672950 24/194 AceView cDNA sequences (see all 194): AK054748 NM_181308 BU674132 NM_181291 CA394445 H47282 BQ130108 BM968464 AI081045 AI337039 AA885446 AW473525 AW594032 AI341938 AW514550 BQ014342 AI435929 AX746714 BU632577 BM728726 BQ101123 BM686307 CB240608 AI092930 GeneLoc Exon Structure
5/21 Alternative Splicing Database (ASD) splice patterns (SP) for WDR20 (see all 21) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | · | 1h | · | 1i | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | · | 13c | · | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | - |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 13d | · | 13e | · | 13f | · | 13g | · | 13h | ^ | 14 | ^ | 15 | ^ | 16 | |
| SP1: | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | - |   | - |   | |   |
ECgene alternative splicing isoforms for WDR20
|
Expression for WDR20 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR20 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GCCCTCTGAG
About this image See WDR20 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for WDR20
SOURCE GeneReport for Unigene cluster: Hs.36859 SABiosciences Custom PCR Arrays for WDR20
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR20 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR20 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR20 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR20 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR20 |
Orthologs for WDR20 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WDR20 gene from 8/29 species (see all 29) About this table
ENSEMBL Gene Tree for WDR20 (if available) TreeFam Gene Tree for WDR20 (if available)  |
Paralogs for WDR20 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for WDR20 gene
- DMWD2
2 SIMAP similar genes for WDR20 using alignment to 11 protein entries: WDR20_HUMAN (see all proteins):DKFZp686P0251 DMWD
WDR20 for paralogs About GeneDecksing
|
Genomic Variants for WDR20 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 14 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR20 (102605840 - 102691184 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for WDR20 2 CNVs: 58647 71965  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR20 |
|
Disorders
/ Diseases for WDR20 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDR20 for disorders About GeneDecksing
8 diseases for WDR20: About MalaCardssilver-russell syndrome beckwith-wiedemann syndrome mitral valve insufficiency enamel caries dental caries locked-in syndrome fanconi's anemia anemia 4 diseases from the University of Copenhagen DISEASES database for WDR20:Silver-Russell syndrome Beckwith-Wiedemann syndrome Enamel caries Mitral valve insufficiency Human Genome Epidemiology (HuGE) Navigator: WDR20 (3 documents) Export disorders for WDR20 gene to outside databases
|
Publications for WDR20 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR20 gene, integrated from 9 sources (see all 23): (articles sorted by number of sources associating them with WDR20) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Regulation of histone H2A and H2B deubiquitination an d Xenopus development by USP12 and USP46. (PubMed id 21183687)1 Joo H.Y....Wang H. (2011)
- WDR20 regulates activity of the USP12 x UAF1 deubiqui tinating enzyme complex. (PubMed id 20147737)1 Kee Y....D'Andrea A.D. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
|
External Searches for WDR20 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing WDR20 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR20 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR20 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for WDR20 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR20 gene: Search GeneIP for patents involving WDR20
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for WDR20 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | |
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 | | WDR20 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR20 |
|  |  |  | | | Search ThermoFisher Antibodies for WDR20 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR20 |
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