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Aliases for WDR20 Gene

Aliases for WDR20 Gene

  • WD Repeat Domain 20 2 3 5
  • WD Repeat-Containing Protein 20 3
  • Protein DMR 4
  • DMR 3

External Ids for WDR20 Gene

Previous GeneCards Identifiers for WDR20 Gene

  • GC14P096421
  • GC14P100596
  • GC14P101675
  • GC14P102606
  • GC14P082785
  • GC14P102146
  • GC14P102147
  • GC14P102252
  • GC14P102286
  • GC14P102461
  • GC14P102632

Summaries for WDR20 Gene

Entrez Gene Summary for WDR20 Gene

  • This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for WDR20 Gene

WDR20 (WD Repeat Domain 20) is a Protein Coding gene. Among its related pathways are Deubiquitination and Metabolism of proteins. An important paralog of this gene is DMWD.

UniProtKB/Swiss-Prot for WDR20 Gene

  • Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336).

Additional gene information for WDR20 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR20 Gene

Genomics for WDR20 Gene

Regulatory Elements for WDR20 Gene

Enhancers for WDR20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H103103 1.6 Ensembl ENCODE dbSUPER 44.7 +965.3 965325 3 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 XRCC3 WDR20 CDC42BPB RCOR1 BAG5 ZNF839 ENSG00000259444 ENSG00000260285 RPL23AP11 KLC1
GH14H102084 2 FANTOM5 Ensembl ENCODE dbSUPER 32.4 -52.6 -52572 4 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 ZNF207 PAF1 WDR20 RCOR1 HSP90AA1 ZNF839 ENSG00000258959 MOK PIR41764 GC14P103106
GH14H102522 2 FANTOM5 Ensembl ENCODE dbSUPER 30.5 +386.5 386491 6 HDGF PKNOX1 MLX ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 RCOR1 WDR20 TECPR2 MOK ANKRD9 ZNF839 RPL23AP11 CDC42BPB TRAF3 RNU6-244P
GH14H102303 1.5 Ensembl ENCODE dbSUPER 26 +165.4 165351 2 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 GLIS2 ELK1 WDR20 HSP90AA1 ENSG00000271780 RCOR1 CDC42BPB MOK GC14P103105
GH14H102262 1.4 Ensembl ENCODE dbSUPER 20.8 +124.3 124311 3 ELF3 ZFP64 DMAP1 ZBTB40 THRB RARA ZNF121 SCRT2 MIXL1 ZNF202 MOK WDR20 TECPR2 CINP HSP90AA1 GC14P103095 GC14P103105
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR20 on UCSC Golden Path with GeneCards custom track

Promoters for WDR20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000073335 397 2601 HDGF FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 SP3

Genomic Location for WDR20 Gene

Chromosome:
14
Start:
102,139,503 bp from pter
End:
102,224,847 bp from pter
Size:
85,345 bases
Orientation:
Plus strand

Genomic View for WDR20 Gene

Genes around WDR20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR20 Gene

Proteins for WDR20 Gene

  • Protein details for WDR20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBZ3-WDR20_HUMAN
    Recommended name:
    WD repeat-containing protein 20
    Protein Accession:
    Q8TBZ3
    Secondary Accessions:
    • B4DN18
    • E7EUY8
    • F8W9S4
    • G3V2F8
    • G3V5R0
    • H0YJJ1
    • Q86TU2
    • Q8NCN7
    • Q8WXX2
    • Q9UF86

    Protein attributes for WDR20 Gene

    Size:
    569 amino acids
    Molecular mass:
    62893 Da
    Quaternary structure:
    • Interacts with USP12 (PubMed:20147737, PubMed:27373336). Component of the USP12/WDR20/WDR48 deubiquitinating complex (PubMed:20147737, PubMed:27373336). Interacts with USP46 (PubMed:20147737).
    SequenceCaution:
    • Sequence=AAL56014.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for WDR20 Gene

    Alternative splice isoforms for WDR20 Gene

neXtProt entry for WDR20 Gene

Post-translational modifications for WDR20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR20 Gene

Domains & Families for WDR20 Gene

Gene Families for WDR20 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WDR20 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR20: view

No data available for UniProtKB/Swiss-Prot for WDR20 Gene

Function for WDR20 Gene

Molecular function for WDR20 Gene

UniProtKB/Swiss-Prot Function:
Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336).

Phenotypes From GWAS Catalog for WDR20 Gene

Gene Ontology (GO) - Molecular Function for WDR20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19615732
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS --
genes like me logo Genes that share ontologies with WDR20: view
genes like me logo Genes that share phenotypes with WDR20: view

Animal Model Products

CRISPR Products

miRNA for WDR20 Gene

Clone Products

  • Applied Biological Materials Clones for WDR20
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR20 Gene

Localization for WDR20 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR20 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for WDR20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with WDR20: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for WDR20 Gene

Pathways & Interactions for WDR20 Gene

genes like me logo Genes that share pathways with WDR20: view

Pathways by source for WDR20 Gene

Gene Ontology (GO) - Biological Process for WDR20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016579 protein deubiquitination TAS,IBA --
genes like me logo Genes that share ontologies with WDR20: view

No data available for SIGNOR curated interactions for WDR20 Gene

Drugs & Compounds for WDR20 Gene

No Compound Related Data Available

Transcripts for WDR20 Gene

Unigene Clusters for WDR20 Gene

WD repeat domain 20:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for WDR20
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for WDR20 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c ·
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - -
SP14: - - - - - - - -
SP15: - - - - - - -
SP16: - - - - -
SP17: - - - -
SP18: - - - - - - - - - - - -
SP19: - -
SP20: - - - - - - - - - - - - - - - - - -
SP21: - - - - - - - - - - - - -

ExUns: 13d · 13e · 13f · 13g · 13h ^ 14 ^ 15 ^ 16
SP1: - - - - -
SP2:
SP3:
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - - -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: - - - - - -
SP21:

Relevant External Links for WDR20 Gene

GeneLoc Exon Structure for
WDR20
ECgene alternative splicing isoforms for
WDR20

Expression for WDR20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR20 Gene

Protein differential expression in normal tissues from HIPED for WDR20 Gene

This gene is overexpressed in Platelet (26.0), Frontal cortex (8.6), Fetal Brain (8.1), and NK cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR20 Gene



Protein tissue co-expression partners for WDR20 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR20 Gene:

WDR20

SOURCE GeneReport for Unigene cluster for WDR20 Gene:

Hs.36859

Evidence on tissue expression from TISSUES for WDR20 Gene

  • Liver(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with WDR20: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR20 Gene

Orthologs for WDR20 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR20 33 34
  • 99.66 (n)
mouse
(Mus musculus)
Mammalia Wdr20a 34
  • 98 (a)
OneToMany
Wdr20 33 16
  • 93.5 (n)
Wdr20b 34
  • 93 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia WDR20 34
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR20 34
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr20 33
  • 93.98 (n)
cow
(Bos Taurus)
Mammalia WDR20 33 34
  • 89.5 (n)
dog
(Canis familiaris)
Mammalia WDR20 33 34
  • 87.89 (n)
chicken
(Gallus gallus)
Aves WDR20 33 34
  • 88.56 (n)
lizard
(Anolis carolinensis)
Reptilia WDR20 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr20 33
  • 82.86 (n)
Str.15335 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.12032 33
zebrafish
(Danio rerio)
Actinopterygii wdr20a 34
  • 84 (a)
OneToMany
si:dkey-241l7.1 33
  • 75.59 (n)
wdr20b 34
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6420 33 34
  • 55.97 (n)
worm
(Caenorhabditis elegans)
Secernentea hpo-22 33
  • 49.64 (n)
wdr-20 34
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToMany
Species where no ortholog for WDR20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR20 Gene

ENSEMBL:
Gene Tree for WDR20 (if available)
TreeFam:
Gene Tree for WDR20 (if available)

Paralogs for WDR20 Gene

Paralogs for WDR20 Gene

(2) SIMAP similar genes for WDR20 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with WDR20: view

Variants for WDR20 Gene

Sequence variations from dbSNP and Humsavar for WDR20 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000002600 -- 102,182,320(+) AGAGT(A/G)AAACA intron-variant
rs1000035258 -- 102,181,880(+) GGTTG(A/G)CCTGC intron-variant
rs1000045271 -- 102,180,396(+) CACTC(G/T)TTAGA intron-variant
rs1000055689 -- 102,139,847(+) GGGAA(A/G)AGGGA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000099013 -- 102,174,093(+) TGCTT(A/G)GAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR20 Gene

Variant ID Type Subtype PubMed ID
dgv25n68 CNV loss 17160897
esv22037 CNV gain 19812545
esv2665920 CNV deletion 23128226
esv2668977 CNV deletion 23128226
esv2669943 CNV deletion 23128226
esv2678767 CNV deletion 23128226
esv3552075 CNV deletion 23714750
esv3552076 CNV deletion 23714750
esv3635544 CNV loss 21293372
esv3635545 CNV loss 21293372
esv3635546 CNV loss 21293372
esv3635547 CNV gain 21293372
nsv1071172 CNV deletion 25765185
nsv1429 CNV deletion 18451855
nsv473296 CNV novel sequence insertion 20440878
nsv512376 CNV loss 21212237
nsv565947 CNV gain 21841781
nsv819548 CNV loss 19587683

Variation tolerance for WDR20 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 32.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR20 Gene

Disorders for WDR20 Gene

Relevant External Links for WDR20

Genetic Association Database (GAD)
WDR20
Human Genome Epidemiology (HuGE) Navigator
WDR20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR20

No disorders were found for WDR20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR20 Gene

Publications for WDR20 Gene

  1. Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20. (PMID: 27373336) Li H … Zheng N (Molecular cell 2016) 3 4 60
  2. WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex. (PMID: 20147737) Kee Y … D'Andrea AD (The Journal of biological chemistry 2010) 3 4 60
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for WDR20 Gene

Sources for WDR20 Gene

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