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Aliases for WDR20 Gene

Aliases for WDR20 Gene

  • WD Repeat Domain 20 2 3 5
  • Protein DMR 4
  • DMR 3

External Ids for WDR20 Gene

Previous GeneCards Identifiers for WDR20 Gene

  • GC14P096421
  • GC14P100596
  • GC14P101675
  • GC14P102606
  • GC14P082785
  • GC14P102146
  • GC14P102147

Summaries for WDR20 Gene

Entrez Gene Summary for WDR20 Gene

  • This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for WDR20 Gene

WDR20 (WD Repeat Domain 20) is a Protein Coding gene. Diseases associated with WDR20 include locked-in syndrome. An important paralog of this gene is ENSG00000268434.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR20 Gene

Genomics for WDR20 Gene

Regulatory Elements for WDR20 Gene

Enhancers for WDR20 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR20 on UCSC Golden Path with GeneCards custom track

Promoters for WDR20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR20 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR20 Gene

Chromosome:
14
Start:
102,139,503 bp from pter
End:
102,224,847 bp from pter
Size:
85,345 bases
Orientation:
Plus strand

Genomic View for WDR20 Gene

Genes around WDR20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR20 Gene

Proteins for WDR20 Gene

  • Protein details for WDR20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBZ3-WDR20_HUMAN
    Recommended name:
    WD repeat-containing protein 20
    Protein Accession:
    Q8TBZ3
    Secondary Accessions:
    • B4DN18
    • E7EUY8
    • F8W9S4
    • G3V2F8
    • G3V5R0
    • H0YJJ1
    • Q86TU2
    • Q8NCN7
    • Q8WXX2
    • Q9UF86

    Protein attributes for WDR20 Gene

    Size:
    569 amino acids
    Molecular mass:
    62893 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL56014.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR20 Gene

neXtProt entry for WDR20 Gene

Proteomics data for WDR20 Gene at MOPED

Post-translational modifications for WDR20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR20 Gene

Domains & Families for WDR20 Gene

Gene Families for WDR20 Gene

Protein Domains for WDR20 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TBZ3

UniProtKB/Swiss-Prot:

WDR20_HUMAN :
  • Contains 7 WD repeats.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR20: view

Function for WDR20 Gene

genes like me logo Genes that share phenotypes with WDR20: view

miRNA for WDR20 Gene

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR20 Gene

Localization for WDR20 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR20 Gene COMPARTMENTS Subcellular localization image for WDR20 gene
Compartment Confidence
cytosol 3
nucleus 2
golgi apparatus 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR20 Gene

Pathways & Interactions for WDR20 Gene

SuperPathways for WDR20 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR20 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR20 Gene

Drugs & Compounds for WDR20 Gene

No Compound Related Data Available

Transcripts for WDR20 Gene

Unigene Clusters for WDR20 Gene

WD repeat domain 20:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR20 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c ·
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - -
SP14: - - - - - - - -
SP15: - - - - - - -
SP16: - - - - -
SP17: - - - -
SP18: - - - - - - - - - - - -
SP19: - -
SP20: - - - - - - - - - - - - - - - - - -
SP21: - - - - - - - - - - - - -

ExUns: 13d · 13e · 13f · 13g · 13h ^ 14 ^ 15 ^ 16
SP1: - - - - -
SP2:
SP3:
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - - -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: - - - - - -
SP21:

Relevant External Links for WDR20 Gene

GeneLoc Exon Structure for
WDR20
ECgene alternative splicing isoforms for
WDR20

Expression for WDR20 Gene

mRNA expression in normal human tissues for WDR20 Gene

Protein differential expression in normal tissues from HIPED for WDR20 Gene

This gene is overexpressed in Platelet (26.0), Frontal cortex (8.6), Fetal Brain (8.1), and NK cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR20 Gene



SOURCE GeneReport for Unigene cluster for WDR20 Gene Hs.36859

genes like me logo Genes that share expression patterns with WDR20: view

Protein tissue co-expression partners for WDR20 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR20 Gene

Orthologs for WDR20 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR20 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR20 35
  • 89.5 (n)
  • 96.3 (a)
WDR20 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR20 35
  • 87.89 (n)
  • 92.56 (a)
WDR20 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr20 35
  • 93.5 (n)
  • 98.23 (a)
Wdr20 16
Wdr20a 36
  • 98 (a)
OneToMany
Wdr20b 36
  • 93 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia WDR20 35
  • 99.66 (n)
  • 99.83 (a)
WDR20 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr20 35
  • 93.98 (n)
  • 97.93 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR20 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR20 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR20 35
  • 88.56 (n)
  • 98.1 (a)
WDR20 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR20 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15335 35
wdr20 35
  • 82.86 (n)
  • 96.44 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12032 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-241l7.1 35
  • 75.59 (n)
  • 89.64 (a)
wdr20a 36
  • 84 (a)
OneToMany
wdr20b 36
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6420 35
  • 55.97 (n)
  • 55.35 (a)
CG6420 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea wdr-20 36
  • 32 (a)
OneToMany
hpo-22 35
  • 49.64 (n)
  • 46.35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for WDR20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR20 Gene

ENSEMBL:
Gene Tree for WDR20 (if available)
TreeFam:
Gene Tree for WDR20 (if available)

Paralogs for WDR20 Gene

Paralogs for WDR20 Gene

(2) SIMAP similar genes for WDR20 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with WDR20: view

Variants for WDR20 Gene

Sequence variations from dbSNP and Humsavar for WDR20 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs17852545 - 102,208,646(+) GGTTC(A/C/T)CGGTT intron-variant, nc-transcript-variant, reference, missense, utr-variant-3-prime, utr-variant-5-prime
rs12888595 - 102,209,500(+) ATGCT(G/T)GCAGC intron-variant, nc-transcript-variant, reference, missense, utr-variant-3-prime
rs10352 -- 102,210,470(+) AAAAC(A/C)CATTT intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1307670 -- 102,176,298(-) cctgc(C/T)tcagc intron-variant
rs1307671 -- 102,176,116(-) tttcc(A/G)gccCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR20 Gene

Variant ID Type Subtype PubMed ID
dgv25n68 CNV Loss 17160897
esv2678767 CNV Deletion 23128226
nsv512376 CNV Loss 21212237
esv2665920 CNV Deletion 23128226
esv2669943 CNV Deletion 23128226
esv2668977 CNV Deletion 23128226
nsv819548 CNV Loss 19587683
nsv1429 CNV Loss 18451855
esv22037 CNV Gain 19812545

Variation tolerance for WDR20 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 32.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR20 Gene

HapMap Linkage Disequilibrium report
WDR20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR20 Gene

Disorders for WDR20 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WDR20 Gene - From: DISEASES

Disorder Aliases PubMed IDs
locked-in syndrome
  • locked in syndrome
- elite association - COSMIC cancer census association via MalaCards
Search WDR20 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WDR20

Genetic Association Database (GAD)
WDR20
Human Genome Epidemiology (HuGE) Navigator
WDR20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR20
genes like me logo Genes that share disorders with WDR20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR20 Gene

Publications for WDR20 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for WDR20 Gene

Sources for WDR20 Gene

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