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WDR20 Gene

protein-coding   GIFtS: 50

GC14P101675
WD repeat domain 20
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DMR 1, 2
FLJ33659 1, 2
MGC33177 1, 2
MGC33183 2
Descriptions
Protein DMR 3
WD repeat domain 20 2
External Ids
HGNC: 196671
Entrez Gene: 918332
UniProtKB: Q8TBZ33
Ensembl: ENSG000001401537
Search outside databases for aliases for WDR20 gene

Previous GC identifers: GC14P096421 GC14P100596

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for WDR20:
This gene encodes a WD repeat-containing protein. Multiple alternatively spliced transcript
variants have been found for this gene, but the full-length nature of some variants has not been
defined. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WDR20 gene  

Entrez Gene cytogenetic band: 14q32.31   Ensembl cytogenetic band:  14q32.31   HGNC cytogenetic band: 14q32.31

WDR20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P101675:     (about GC identifiers)

Start:
101,675,965 bp from pter
End:
101,759,763 bp from pter
Size:
83,799 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000014.7  NT_026437.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WDR20_HUMAN, Q8TBZ3 (See protein sequence)
Recommended Name: WD repeat-containing protein 20  
Size: 569 amino acids; 62893 Da
Secondary accessions: Q8WXX2 Q9UF86
Alternative splicing: 2 isoforms:  Q8TBZ3-1   Q8TBZ3-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (4 alternative transcripts): 
    NP_653175.2  NP_851808.1  NP_851819.1  NP_851825.1  


    ENSEMBL proteins: 
    ENSP00000341037 ENSP00000299135 ENSP00000314209 ENSP00000335434 ENSP00000385755 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (WDR20)
    Human Recombinant Proteins from Abnova (WDR20)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA18029348
    GO:0005737 cytoplasm IDA18029348
    About this table

    Antibodies for WDR20: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for WDR20
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (WDR20), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (WDR20)
    Novus Biologicals Antibodies for WDR20

    Assays for WDR20: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR019782 WD40_repeat_2
     IPR019775 WD40_repeat_CS
     IPR019781 WD40_repeat_sg
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_region


       GeneDecks  WDR20 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q8TBZ3

    ProtoNet protein and cluster: Q8TBZ3

    UniProtKB/Swiss-Prot: WDR20_HUMAN, Q8TBZ3
    Similarity: Contains 5 WD repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WDR20)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (WDR20)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): BC030654

                  Applied Biosystems Silencer® siRNAs for WDR20

                  Sigma-Aldrich siRNA for WDR20  
                         Sigma-Aldrich shRNA for WDR20  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for WDR20
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_144574
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_144574
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_144574 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_181291

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5/22 Interacting proteins for WDR20 (ENSP000003354343) via UniProtKB, MINT, and/or STRING (see all 22 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTCFENSP000002640103STRING (score=.993)
    IGF2RENSP000003494373STRING (score=.941)
    SNRPNENSP000003751053STRING (score=.941)
    DNMT3LENSP000002701723STRING (score=.93)
    ZCCHC16ENSP000003405903STRING (score=.914)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for WDR20

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WDR20)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (WDR20)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): BC030654

                  Sigma-Aldrich siRNA for WDR20  
                         Sigma-Aldrich shRNA for WDR20  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_144574  NM_181291  NM_181302  NM_181308  

    REFSEQ mRNAs for WDR20 gene (4 alternative transcripts): 

    NM_144574.2   NM_181291.1   NM_181302.1   NM_181308.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_144574  NM_181291  NM_181302  NM_181308  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_144574
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_144574
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_144574 

    Additional cDNA sequence: 

    AB209148.1 AF327354.1 AK054748.1 AK056330.1 AK090978.1 AK130824.1 AK225852.1 AK297727.1 
    AL133558.1 AL832242.1 BC028387.2 BC030654.2 BX248274.1 BX647751.1 CR599444.1 

    24/29 DOTS entries (see all 29 ):

    DT.213857  DT.92060722  DT.111888  DT.92416089  DT.91728613  DT.95151401  DT.101971236  DT.95274540 
    DT.97843329  DT.100794453  DT.101971764  DT.120782022  DT.92065259  DT.100794455  DT.100794451  DT.100794452 
    DT.120782255  DT.91672950  DT.95274539  DT.101972999  DT.120781802  DT.120782001  DT.91901778  DT.99932361 

    24/194 AceView cDNA sequences (see all 194 ):

    CB159530 AI435929 AI085828 AK054748 AI911558 AI125926 AW473525 AI168315 
    AI341938 BM023222 AA885446 AA489728 NM_181291 CB240608 BM968464 BU674132 
    BE674667 AL832242 BE796137 AK090978 AI337039 BQ130108 BQ581505 CF243166 

    highest scoring ESTs for WDR20:

    AI092930 AA004578 AA131031 AA195670 AA437270 AA812073 AA884060 AA927998 AF327354 AI087332 

    Unigene Cluster for WDR20:

    WD repeat domain 20
    Hs.36859  [show with all ESTs]
    Unigene Representative Sequence: AB209148


    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for WDR20 (see all 21 )

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c ·
    SP1:                                                  -     -     -     -     -     -     -     -           -           -     -     -     -     -     -     -   
    SP2:                                                  -     -     -     -     -     -     -                 -     -     -     -     -     -                     
    SP3:                                                  -     -     -     -     -     -     -     -           -           -                                       
    SP4:                                                  -     -     -     -     -     -     -                 -     -     -                                       
    SP5:                                                  -     -     -     -     -     -     -     -           -     -     -                                       

    ExUns: 13d · 13e · 13f · 13g · 13h ^ 14 ^ 15 ^ 16
    SP1:  -     -     -     -     -                     
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                          -     -     -         

    About this scheme

    ECgene alternative splicing isoforms for WDR20

    5 Ensembl transcripts including schematic representations:
    ENST00000342702  ENST00000299135  ENST00000322340  ENST00000335263  ENST00000401892  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    WDR20 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for WDR20

    1 / 2 / 3

    7 probe-sets matching WDR20 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    46100_at2, 3 U95-B 1 1.00 1.00 0.80 0.88 AA131031 0.80 1.00 0.91 1

    53157_at2, 3 U95-B 1 1.00 1.00 0.70 1.13 AI092930 1.00 1.00 1.00 1

    227541_at2, 3 U133-B 1 1.00 1.00 -- -- AA811466 0.60 1.00 0.82 1

    227693_at2, 3 U133-B 1 1.00 1.00 -- -- AI092930 1.00 1.00 1.00 1

    227541_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    227693_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1554549_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCCCTCTGAG

    SOURCE GeneReport for Unigene cluster: Hs.36859
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for WDR20 gene from 5/14 species (see all 14 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    WDR201   -- WD repeat domain 20 87.26(n)
    92.04(a)
    611234  XM_863505.1  XP_868598.1 
    chimpanzee
    (Pan troglodytes)
    WDR201   -- WD repeat domain 20 99.66(n)
    99.83(a)
    453174  XM_001163392.1  XP_001163392.1 
    cow
    (Bos taurus)
    WDR201   -- WD repeat domain 20 89.5(n)
    96.3(a)
    516477  XM_001250893.1  XP_001250894.1 
    rat
    (Rattus norvegicus)
    Wdr20a1   -- WD repeat domain 20a 93.82(n)
    97.88(a)
    314453  XM_234540.4  XP_234540.4 
    mouse
    (Mus musculus)
    Wdr20b5
    Wdr20a1
    125
    WD repeat domain 20b5
    WD repeat domain 20a1
    93.02(n)1
    97.71(a)1
    696411  NM_027149.21  NP_081425.21 
     AK0150145  BC0507785 
    About this table        Species with no ortholog for WDR20

    ENSEMBL Gene Tree for WDR20
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for WDR20 gene
    DMWD2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/369 NCBI SNPs in WDR20 are shown (see all 369 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 105)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs71521241,2
    A,C,F,H101759328(+) AAATTC/GAGCTG 1 -- ut31 ese37Minor allele frequency- G:0.00EU EA WA NA 562
    rs128885951,2
    C,F,H101745590(+) ATGCTG/TGCAGC 4 G/C mis19Minor allele frequency- T:0.01EU EA WA NA 932
    rs80090591,2
    F,H101759765(+) TATACC/TGCTTG 1 -- ng314Minor allele frequency- T:0.03EU EA WA 420
    rs8855861,2
    F101759139(-) GCAGCA/GGGAGC 1 -- ut31 ese34Minor allele frequency- G:0.42NA PA MN 436
    --
    rs111606761,2
    A101759941(+) GTCGCC/TTCACA 1 -- ng310--------
    --
    rs64781,2
    F101759646(-) TATACAT/-ATAAT 1 -- ut314Minor allele frequency- -:0.10EU NA EA 342
    rs65759001,2
    A,C,F,H101745103(+) GGTGGG/CGAGGA 4 G/G syn1 ese38Minor allele frequency- C:0.31EU EA WA 836
    rs71408131,2
    A,C,F,H101716956(+) GTTTCC/TGCCAT 4 -- int15Minor allele frequency- T:0.41EA WA NA 436
    rs71545531,2
    A,C,F,H101755936(+) AGAAGA/GCGAGA 1 -- int17Minor allele frequency- G:0.27NA EU EA WA 558
    rs65758971,2
    A,C,F,H101716878(+) TTGTCG/ATAACC 4 -- int18Minor allele frequency- A:0.30EA NA EU WA 628
    About this table

    HapMap Linkage Disequilibrium images for WDR20 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10 PubMed articles for WDR20 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 91833 HGNC: 19667 AceView: WDR20 Ensembl:ENSG00000140153 euGenes: HUgn91833
    ECgene: WDR20 H-InvDB: WDR20
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for WDR20:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for WDR20-related products

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     Millipore Immunoassay Services
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     Predesigned and custom siRNAs for WDR20 Antibodies for WDR20
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for WDR20 Browse small molecules at Sigma-Aldrich
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