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Aliases for WDR20 Gene

Aliases for WDR20 Gene

  • WD Repeat Domain 20 2 3
  • WD Repeat-Containing Protein 20 3
  • Protein DMR 4
  • DMR 3

External Ids for WDR20 Gene

Summaries for WDR20 Gene

Entrez Gene Summary for WDR20 Gene

  • This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for WDR20 Gene

WDR20 (WD Repeat Domain 20) is a Protein Coding gene. Diseases associated with WDR20 include enamel caries and mitral valve insufficiency. An important paralog of this gene is ENSG00000268434.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR20 Gene

Genomics for WDR20 Gene

Genomic Location for WDR20 Gene

Start:
102,139,503 bp from pter
End:
102,224,847 bp from pter
Size:
85,345 bases
Orientation:
Plus strand

Genomic View for WDR20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR20 Gene

Regulatory Elements for WDR20 Gene

Proteins for WDR20 Gene

  • Protein details for WDR20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBZ3-WDR20_HUMAN
    Recommended name:
    WD repeat-containing protein 20
    Protein Accession:
    Q8TBZ3
    Secondary Accessions:
    • B4DN18
    • E7EUY8
    • F8W9S4
    • G3V2F8
    • G3V5R0
    • H0YJJ1
    • Q86TU2
    • Q8NCN7
    • Q8WXX2
    • Q9UF86

    Protein attributes for WDR20 Gene

    Size:
    569 amino acids
    Molecular mass:
    62893 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL56014.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR20 Gene

neXtProt entry for WDR20 Gene

Proteomics data for WDR20 Gene at MOPED

Post-translational modifications for WDR20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR20 Gene

Domains for WDR20 Gene

Gene Families for WDR20 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for WDR20 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TBZ3

UniProtKB/Swiss-Prot:

WDR20_HUMAN
Similarity:
  • Contains 7 WD repeats.:
    • Q8TBZ3
genes like me logo Genes that share domains with WDR20: view

Function for WDR20 Gene

Gene Ontology (GO) - Molecular Function for WDR20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WDR20: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for WDR20 Gene

Localization for WDR20 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR20 Gene COMPARTMENTS Subcellular localization image for WDR20 gene
Compartment Confidence
cytosol 3
nucleus 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR20 Gene

Pathways for WDR20 Gene

SuperPathways for WDR20 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR20 Gene

None

No data available for Pathways by source for WDR20 Gene

Transcripts for WDR20 Gene

Unigene Clusters for WDR20 Gene

WD repeat domain 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR20 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c ·
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - -
SP14: - - - - - - - -
SP15: - - - - - - -
SP16: - - - - -
SP17: - - - -
SP18: - - - - - - - - - - - -
SP19: - -
SP20: - - - - - - - - - - - - - - - - - -
SP21: - - - - - - - - - - - - -

ExUns: 13d · 13e · 13f · 13g · 13h ^ 14 ^ 15 ^ 16
SP1: - - - - -
SP2:
SP3:
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - - -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: - - - - - -
SP21:

Relevant External Links for WDR20 Gene

GeneLoc Exon Structure for
WDR20
ECgene alternative splicing isoforms for
WDR20

Expression for WDR20 Gene

mRNA expression in normal human tissues for WDR20 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR20 Gene

SOURCE GeneReport for Unigene cluster for WDR20 Gene Hs.36859

genes like me logo Genes that share expressions with WDR20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR20 Gene

Orthologs for WDR20 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR20 35
  • 99.66 (n)
  • 99.83 (a)
WDR20 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR20 35
  • 89.5 (n)
  • 96.3 (a)
WDR20 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR20 35
  • 87.89 (n)
  • 92.56 (a)
WDR20 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr20 35
  • 93.5 (n)
  • 98.23 (a)
Wdr20a 16
Wdr20a 36
  • 98 (a)
OneToMany
Wdr20b 36
  • 93 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia WDR20 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR20 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr20 35
  • 93.98 (n)
  • 97.93 (a)
chicken
(Gallus gallus)
Aves WDR20 35
  • 88.56 (n)
  • 98.1 (a)
WDR20 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR20 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12032 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15335 35
wdr20 35
  • 82.86 (n)
  • 96.44 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-241l7.1 35
  • 75.59 (n)
  • 89.64 (a)
wdr20a 36
  • 84 (a)
OneToMany
wdr20b 36
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6420 35
  • 55.97 (n)
  • 55.35 (a)
CG6420 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hpo-22 35
  • 49.64 (n)
  • 46.35 (a)
wdr-20 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for WDR20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR20 Gene

ENSEMBL:
Gene Tree for WDR20 (if available)
TreeFam:
Gene Tree for WDR20 (if available)

Paralogs for WDR20 Gene

Paralogs for WDR20 Gene

Selected SIMAP similar genes for WDR20 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with WDR20: view

Variants for WDR20 Gene

Sequence variations from dbSNP and Humsavar for WDR20 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs6478 -- 102,223,556(-) TATAC(-/AT)ATAAT utr-variant-3-prime, intron-variant
rs10352 -- 102,210,470(+) AAAAC(A/C)CATTT utr-variant-3-prime, intron-variant, nc-transcript-variant, downstream-variant-500B
rs869038 -- 102,215,483(+) agttc(A/C/T)gggat downstream-variant-500B, intron-variant
rs885586 -- 102,223,049(-) GCAGC(A/G)GGAGC utr-variant-3-prime, downstream-variant-500B, intron-variant
rs960998 -- 102,213,211(-) CCTCA(A/G)AGAAA utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR20 Gene

Variant ID Type Subtype PubMed ID
dgv25n68 CNV Loss 17160897
esv2678767 CNV Deletion 23128226
nsv512376 CNV Loss 21212237
esv2665920 CNV Deletion 23128226
esv2669943 CNV Deletion 23128226
esv2668977 CNV Deletion 23128226
nsv819548 CNV Loss 19587683
nsv1429 CNV Loss 18451855
esv22037 CNV Gain 19812545

Relevant External Links for WDR20 Gene

HapMap Linkage Disequilibrium report
WDR20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR20 Gene

Disorders for WDR20 Gene

Relevant External Links for WDR20

Genetic Association Database (GAD)
WDR20
Human Genome Epidemiology (HuGE) Navigator
WDR20
genes like me logo Genes that share disorders with WDR20: view

No data available for UniProtKB/Swiss-Prot for WDR20 Gene

Publications for WDR20 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  5. Functional genetic tests of DNA mismatch repair protein activity in Saccharomyces cerevisiae. (PMID: 9630599) Polaczek P. … Bitter G.A. (Gene 1998) 23

Products for WDR20 Gene

Sources for WDR20 Gene

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