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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR19 Gene

protein-coding   GIFtS: 47
GCID: GC04P039184

WD repeat domain 19
 Explore 10 diseases affiliated with
WDR19 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WDR19    

Aliases
for WDR19 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
WD Repeat Domain 191 2     Pwdmp1
DYF-21 2     ATD52
IFT1441 2     CED42
NPHP131 2     PWDMP2
ORF261 2     Intraflagellar Transport 144 Homolog2
Oseg61 2     WD Repeat Membrane Protein PWDMP2
KIAA16381 3     WD Repeat-Containing Protein 192
FLJ231271     

External Ids:    HGNC: 183401   Entrez Gene: 577282   Ensembl: ENSG000001577967   OMIM: 6081515   UniProtKB: Q8NEZ33   

Export aliases for WDR19 gene to outside databases

Previous GC identifers: GC00U991193 GC04P039006 GC04P038860 GC04P038508


Summaries
for WDR19 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WDR19:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately
40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or
multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle
progression, signal transduction, apoptosis, and gene regulation. This protein contains six WD repeats, a clathrin
heavy-chain repeat, and three transmembrane domains. This gene is conserved from C. elegans to human. It may
participate in androgen-regulated signaling mechanisms or in the vesicular trafficking of androgen-regulated secretory
processes. Alternatively spliced transcript variants encoding distinct isoforms have been reported but the full-length
nature of one of these variants has not been defined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WDR19_HUMAN, Q8NEZ3
Function: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Involved in
cilia function and/or assembly (By similarity)




Genomic Views
for WDR19 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016297.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR19 gene promoter:
         Max1   NF-YC   CUTL1   HNF-1A   CREB   E2F-1   E2F   HNF-1   deltaCREB   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WDR19 promoter sequence
   Search SABiosciences Chromatin IP Primers for WDR19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p14

WDR19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR19 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P039184:  view genomic region     (about GC identifiers)

Start:
 39,184,024 bp from pter      End:
 39,287,430 bp from pter
Size:
 103,407 bases      Orientation:
 plus strand

Proteins
for WDR19 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WDR19_HUMAN, Q8NEZ3 (See protein sequence)
Recommended Name: WD repeat-containing protein 19  
Size: 1342 amino acids; 151581 Da
Subunit: Component of the IFT complex A (IFT-A)
Subcellular location: Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By
similarity). Note=Localizes to photoreceptor connecting cilia, to the base of motile cilia in brain ependymal cells
and to the base of and along primary cilia in kidney cells (By similarity)
Developmental stage: Expressed in fetal lung
Sequence caution: Sequence=AAH32578.1; Type=Frameshift; Positions=421;
Secondary accessions: B5MEF2 Q8N5B4 Q9H5S0 Q9HCD4
Alternative splicing: 2 isoforms:  Q8NEZ3-1   Q8NEZ3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR19: NX_Q8NEZ3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NEZ3

    • WDR19 Protein expression data from MOPED and PaxDb:    About this image 
    WDR19 Protein Expression
    REFSEQ proteins: NP_079408.3  
    ENSEMBL proteins: 
     ENSP00000382717   ENSP00000423706   ENSP00000424319   ENSP00000426918   ENSP00000421888  
     ENSP00000425949   ENSP00000423491   ENSP00000421401   ENSP00000288634  

    Human Recombinant Protein Products for WDR19: 
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    Uscn Proteins for WDR19

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005932microtubule basal body IEA--
    GO:0031513nonmotile primary cilium ISS--
    GO:0031514motile cilium ISS--
    GO:0032391photoreceptor connecting cilium ISS--

    WDR19 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for WDR19 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WDR19 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR011990 TPR-like_helical
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8NEZ3

    ProtoNet protein and cluster: Q8NEZ3

    UniProtKB/Swiss-Prot: WDR19_HUMAN, Q8NEZ3
    Similarity: Contains 6 TPR repeats
    Similarity: Contains 6 WD repeats


    Function
    for WDR19 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR19_HUMAN, Q8NEZ3
    Function: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Involved in
    cilia function and/or assembly (By similarity)
    Induction: By androgenic hormones. Expression increased 3-fold in an androgen-stimulated androgen-sensitive prostate
    adenocarcinoma cell line compared with androgen-deprived cells

    Phenotypes:
         11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Wdr19):

     cellular  craniofacial  digestive/alimentary  embryogenesis  hearing/vestibular/ear 
     limbs/digits/tail  mortality/aging  muscle  nervous system  skeleton 
     vision/eye 

    WDR19 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for WDR19 

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate WDR19:
    hsa-miR-590-3p hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmid: WDR19 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR19


    Pathways & Interactions
    for WDR19 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR19

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0030030cell projection organization ----
    GO:0030326embryonic limb morphogenesis IEA--
    GO:0031076embryonic camera-type eye development IEA--
    GO:0042384cilium assembly IEA--

    WDR19 for ontologies           About GeneDecksing



    Drugs & Compounds
    for WDR19 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR19
    Search CenterWatch for drugs/clinical trials and news about WDR19 

    Transcripts
    for WDR19 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WDR19 gene: 
    NM_025132.3  

    Unigene Cluster for WDR19:

    WD repeat domain 19
    Hs.438482  [show with all ESTs]
    Unigene Representative Sequence: NM_025132
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000399820(uc010ifl.1 uc003gtu.1 uc003gtv.3 uc011byi.2)
    ENST00000503697 ENST00000511729 ENST00000506869 ENST00000509560 ENST00000512112
    ENST00000505055 ENST00000502389 ENST00000506503 ENST00000512448 ENST00000512095(uc003gtw.1)
    ENST00000507228 ENST00000515631 ENST00000502718 ENST00000512534 ENST00000512588
    ENST00000503733 ENST00000510315

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate WDR19:
    hsa-miR-590-3p hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmid: WDR19 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB046858.1 AK026780.1 AK225588.1 AK294730.1 AK296112.1 AK304161.1 AK308803.1 AY029257.1 
    BC032578.1 BC131501.1 

    12 DOTS entries:

    DT.114006  DT.92040399  DT.100026571  DT.100755175  DT.92416906  DT.92057945  DT.99971287  DT.92418702 
    DT.100736238  DT.121259470  DT.95343830  DT.97839733 

    24/97 AceView cDNA sequences (see all 97):

    AA363808 AA281724 AW450839 BP376333 BU621014 BQ923434 BE046347 BM719838 
    BQ950404 AA934791 BU948584 BQ181511 AI969388 BU679219 AB046858 NM_025132 
    AA281901 AL702961 AL711455 BU686662 AY029257 AA445953 BU948827 AA443312 

    GeneLoc Exon Structure


    Expression
    for WDR19 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAACCTTGCT
    WDR19 Expression
    About this image

    WDR19 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See WDR19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR19

    SOURCE GeneReport for Unigene cluster: Hs.438482

    UniProtKB/Swiss-Prot: WDR19_HUMAN, Q8NEZ3
    Tissue specificity: Some isoforms are tissue-specific. Highly expressed in the prostate. Lower expression in the
    cerebellum, pituitary gland, fetal lung, and pancreas. In normal prostate, expressed in both basal and luminal
    epithelial cells. No expression detected in fibromuscular stromal cells, endothelial cells, or infiltrating
    lymphocytes. Uniformed expression in prostate adenocarcinoma cells

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    Orthologs
    for WDR19 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for WDR19 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Wdr191 , 5 WD repeat domain 191, 5 86.18(n)1
    89.63(a)1    		   5 (33.58 cM)5
    2130811  NM_153391.21  NP_700440.21 
     651996965 
    chicken
    (Gallus gallus)    		 Aves WDR191 WD repeat domain 19 78.03(n)
    82.47(a)    		   430829  XM_428380.3  XP_428380.2 
    lizard
    (Anolis carolinensis)    		 Reptilia WDR196
    		 --
    		 79(a)
    		 1 ↔ 1
    		 5(73133219-73178015)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.200032 Transcribed sequence with weak similarity to protein more 73.07(n)    BG307441.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Oseg61 CG11237-PA 50.55(n)
    42.31(a)    		   37245  NM_137582.2  NP_611426.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea dyf-21 Protein DYF-2 49.92(n)
    40.82(a)    		   191342  NM_001083186.1  NP_001076655.1 


    ENSEMBL Gene Tree for WDR19 (if available)
    TreeFam Gene Tree for WDR19 (if available) 

    Paralogs
    for WDR19 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for WDR19 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1620 NCBI SNPs in WDR19 are shown (see all 1620)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 4 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs20183271,2
    		C--38507874(-) ATTTTC/TTTAAT 1 -- us2k1 tfbs33Minor allele frequency- T:0.10NA WA 122
    rs788604941,2
    		F--38508653(+) TTAATC/ATAACA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs731336331,2
    		C--38508887(+) CCCTCC/TGCCTC 1 -- us2k12Minor allele frequency- T:0.06WA 120
    rs49749881,2
    		C,H--38508998(+) GGTGAC/TGGGAA 1 -- ut51 ese35Minor allele frequency- T:0.00NS EA NA 414
    rs1135701411,2
    		--38509208(+) AGAGAG/AAGAGA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1114166921,2
    		C--38509843(+) TGCTCC/TCTGCA 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1128162121,2
    		C--38509961(+) GATGGG/CGTTTC 1 -- int11Minor allele frequency- C:0.50NA 2
    rs1124453691,2
    		C--38509969(+) TTCACC/TGTGTT 1 -- int10--------
    rs284189651,2
    		C--38510790(+) CGGGCG/ATGGTA 1 -- int11Minor allele frequency- A:0.50WA 2
    rs351852011,2
    		C,F--38511585(+) ACGAGA/GTAGTT 1 -- int15Minor allele frequency- G:0.06NA EA 246

    HapMap Linkage Disequilibrium report for WDR19 (39184024 - 39287430 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for WDR19
         2 CNVs: 98684 98685
    Human Gene Mutation Database (HGMD): WDR19

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR19
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR19

    Disorders / Diseases
    for WDR19 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WDR19 for disorders           About GeneDecksing

    OMIM gene information: 608151    OMIM disorders: --

    UniProtKB/Swiss-Prot: WDR19_HUMAN, Q8NEZ3
  • Defects in WDR19 are the cause of cranioectodermal dysplasia type 4 (CED4) [MIM:614378]. CED4 is a disorder
    • primarily characterized by craniofacial, skeletal and ectodermal abnormalities. Clinical features include
    craniosynostosis, narrow rib cage, short limbs, brachydactyly, hypoplastic and widely spaced teeth, sparse hair, skin
    laxity and abnormal nails. Nephronophthisis leading to progressive renal failure, hepatic fibrosis, heart defects, and
    retinitis pigmentosa have also been described
  • Defects in WDR19 are the cause of asphyxiating thoracic dystrophy type 5 (ATD5) [MIM:614376]. ATD5 is an
    • autosomal recessive chondrodysplasia characterized by a severely constricted thoracic cage, short-limbed short
    stature, and polydactyly. It often leads to death in infancy because of respiratory insufficiency. Retinal
    degeneration, cystic renal disease and hepatic disease can be present in affected individuals who survive early
    childhood
  • Defects in WDR19 are the cause of nephronophthisis type 13 (NPHP13) [MIM:614377]. NPHP13 is an autosomal
    • recessive disorder resulting in end-stage renal disease. It is a progressive tubulo-interstitial kidney disorder
    histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial
    fibrosis and, in the advanced stages, medullary cysts

    10 diseases for WDR19:    About MalaCards
    ellis-van creveld syndrome    bardet-biedl syndrome    sensenbrenner syndrome    polydactyly
    prostate adenocarcinoma    adenocarcinoma    prostatitis    prostate cancer
    asphyxiating thoracic dystrophy    nephronophthisis

    4 diseases from the University of Copenhagen DISEASES database for WDR19:
    Sensenbrenner syndrome     Asphyxiating thoracic dystrophy     Polydactyly     Ellis-Van Creveld syndrome

    Export disorders for WDR19 gene to outside databases

    Publications
    for WDR19 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR19 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with WDR19)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human and mouse WDR19,a novel WD- repeat protein exhibiting androgen-regulated expression in prostate epithelium. (PubMed id 12906858)1, 2, 3, 9 Lin B.... Nelson P.S. (2003)
    2. Ciliopathies with skeletal anomalies and renal insufficiency due to mutations in the IFT-A gene WDR19. (PubMed id 22019273)1, 2, 3 Bredrup C.... Arts H.H. (2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
    6. TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. (PubMed id 20889716)2 Mukhopadhyay S....Jackson P.K. (2010)
    7. WDR19 expression is increased in prostate cancer compared with normal cells, but low-intensity expression in cancers is associated with shorter time to biochemical failures and local recurrence. (PubMed id 18316561)1 Lin B....Akslen L.A. (2008)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)2 Nakajima D.... Nagase T. (2002)

    External Searches for WDR19 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing WDR19 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57728 HGNC: 18340 AceView: WDR19 Ensembl:ENSG00000157796 euGenes: HUgn57728
    ECgene: WDR19 H-InvDB: WDR19

    Other Databases showing WDR19 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1638

    Specialized Databases showing WDR19 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR19 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for WDR19 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WDR19 gene:
    Search GeneIP for patents involving WDR19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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