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WDR19 Gene

protein-coding   GIFtS: 50
GCID: GC04P039184

WD Repeat Domain 19

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 191 2     ORF262
ATD52 5     Oseg62
CED42 5     PWDMP2
NPHP132 5     Intraflagellar Transport 144 Homolog2
SRTD52 5     WD Repeat Membrane Protein PWDMP2
Intraflagellar Transport 144 Homolog (Chlamydomonas)1     WD Repeat-Containing Protein 192
DYF-22     KIAA16383
IFT1442     

External Ids:    HGNC: 183401   Entrez Gene: 577282   Ensembl: ENSG000001577967   OMIM: 6081515   UniProtKB: Q8NEZ33   

Export aliases for WDR19 gene to outside databases

Previous GC identifers: GC00U991193 GC04P039006 GC04P038860 GC04P038508


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WDR19 Gene:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of
approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation
of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular
processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein
contains six WD repeats, a clathrin heavy-chain repeat, and three transmembrane domains. This gene is conserved
from C. elegans to human. It may participate in androgen-regulated signaling mechanisms or in the vesicular
trafficking of androgen-regulated secretory processes. Alternatively spliced transcript variants encoding
distinct isoforms have been reported but the full-length nature of one of these variants has not been defined.
(provided by RefSeq, Jul 2008)

GeneCards Summary for WDR19 Gene:
WDR19 (WD repeat domain 19) is a protein-coding gene. Diseases associated with WDR19 include nephronophthisis 13, and cranioectodermal dysplasia 4.

UniProtKB/Swiss-Prot: WDR19_HUMAN, Q8NEZ3
Function: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Involved in
cilia function and/or assembly (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_006238.12  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR19 gene promoter:
         Max1   NF-YC   CUTL1   HNF-1A   CREB   E2F-1   E2F   HNF-1   deltaCREB   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR19 promoter sequence
   Search Chromatin IP Primers for WDR19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p14

WDR19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR19 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P039184:  view genomic region     (about GC identifiers)

Start:
39,184,024 bp from pter      End:
39,287,430 bp from pter
Size:
103,407 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WDR19_HUMAN, Q8NEZ3 (See protein sequence)
Recommended Name: WD repeat-containing protein 19  
Size: 1342 amino acids; 151581 Da
Subunit: Component of the IFT complex A (IFT-A)
Developmental stage: Expressed in fetal lung
Sequence caution: Sequence=AAH32578.1; Type=Frameshift; Positions=421;
Secondary accessions: B5MEF2 Q8N5B4 Q9H5S0 Q9HCD4
Alternative splicing: 2 isoforms:  Q8NEZ3-1   Q8NEZ3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR19: NX_Q8NEZ3

Explore proteomics data for WDR19 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WDR19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079408.3  
    ENSEMBL proteins: 
     ENSP00000382717   ENSP00000423706   ENSP00000426918   ENSP00000421888   ENSP00000425949  
     ENSP00000424319   ENSP00000423491   ENSP00000421401   ENSP00000288634  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFT: Intraflagellar transport homologs
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8NEZ3

    ProtoNet protein and cluster: Q8NEZ3

    UniProtKB/Swiss-Prot: WDR19_HUMAN, Q8NEZ3
    Similarity: Contains 6 TPR repeats
    Similarity: Contains 6 WD repeats


    WDR19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR19_HUMAN, Q8NEZ3
    Function: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Involved in
    cilia function and/or assembly (By similarity)
    Induction: By androgenic hormones. Expression increased 3-fold in an androgen-stimulated androgen-sensitive
    prostate adenocarcinoma cell line compared with androgen-deprived cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    WDR19 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Wdr19):
     cellular  craniofacial  digestive/alimentary  embryogenesis  hearing/vestibular/ear 
     limbs/digits/tail  mortality/aging  muscle  nervous system  skeleton 
     vision/eye 

    WDR19 for phenotypes           About GeneDecksing

    Animal Models:
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    miRNA
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    hsa-mir-335-5p (MIRT017813), hsa-mir-92a-3p (MIRT049394)

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    3 qRT-PCR Assays for microRNAs that regulate WDR19:
    hsa-miR-590-3p hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidWDR19 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WDR19_HUMAN, Q8NEZ3: Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By
    similarity). Note=Localizes to photoreceptor connecting cilia, to the base of motile cilia in brain ependymal
    cells and to the base of and along primary cilia in kidney cells (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    cytosol2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005929cilium ----
    GO:0030991intraciliary transport particle A IDA--
    GO:0031513nonmotile primary cilium ISS--

    WDR19 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR19
    Interactions:

        Search GeneGlobe Interaction Network for WDR19

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0001701in utero embryonic development IEA--
    GO:0007224smoothened signaling pathway ----
    GO:0030326embryonic limb morphogenesis IEA--
    GO:0031076embryonic camera-type eye development IEA--

    WDR19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR19



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WDR19 gene: 
    NM_025132.3  

    Unigene Cluster for WDR19:

    WD repeat domain 19
    Hs.438482  [show with all ESTs]
    Unigene Representative Sequence: NM_025132
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000399820(uc010ifl.1 uc003gtu.1 uc003gtv.3 uc011byi.2)
    ENST00000503697 ENST00000511729 ENST00000509560 ENST00000512112 ENST00000505055
    ENST00000506869 ENST00000502389 ENST00000506503 ENST00000512448 ENST00000512095(uc003gtw.1)
    ENST00000507228 ENST00000515631 ENST00000502718 ENST00000512534 ENST00000512588
    ENST00000503733 ENST00000510315
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate WDR19:
    hsa-miR-590-3p hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidWDR19 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat WDR19
      QuantiFast Probe-based Assays in human, mouse, rat WDR19

    Additional mRNA sequence: 

    AB046858.1 AK026780.1 AK225588.1 AK294730.1 AK296112.1 AK304161.1 AK308803.1 AY029257.1 
    BC032578.1 BC131501.1 

    12 DOTS entries:

    DT.114006  DT.92040399  DT.100026571  DT.100755175  DT.92416906  DT.92057945  DT.99971287  DT.92418702 
    DT.100736238  DT.121259470  DT.95343830  DT.97839733 

    Selected AceView cDNA sequences (see all 97):

    BU679219 BM719838 AA363808 AY029257 BQ181511 AA281724 BU686662 AI969388 
    NM_025132 AL711455 AL702961 AA281901 BP376333 BU948827 BQ923434 AW450839 
    BQ950404 BU621014 AA934791 AA445953 BE046347 BU948584 AB046858 AA858065 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACCTTGCT
    WDR19 Expression
    About this image

    WDR19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR19 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.438482

    UniProtKB/Swiss-Prot: WDR19_HUMAN, Q8NEZ3
    Tissue specificity: Some isoforms are tissue-specific. Highly expressed in the prostate. Lower expression in the
    cerebellum, pituitary gland, fetal lung, and pancreas. In normal prostate, expressed in both basal and luminal
    epithelial cells. No expression detected in fibromuscular stromal cells, endothelial cells, or infiltrating
    lymphocytes. Uniformed expression in prostate adenocarcinoma cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WDR19 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr191 , 5 WD repeat domain 191, 5 86.18(n)1
    89.63(a)1
      5 (33.58 cM)5
    2130811  NM_153391.21  NP_700440.21 
     651996965 
    chicken
    (Gallus gallus)
    Aves WDR191 WD repeat domain 19 78.06(n)
    82.5(a)
      430829  XM_428380.4  XP_428380.3 
    lizard
    (Anolis carolinensis)
    Reptilia WDR196
    WD repeat domain 19
    79(a)
    1 ↔ 1
    5(73133080-73182117)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.200032 Transcribed sequence with weak similarity to protein more 73.07(n)    BG307441.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Oseg61 Oseg6 50.65(n)
    42.39(a)
      37245  NM_137582.3  NP_611426.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dyf-21 dyf-2 49.97(n)
    40.91(a)
      191342  NM_001083186.1  NP_001076655.1 


    ENSEMBL Gene Tree for WDR19 (if available)
    TreeFam Gene Tree for WDR19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR19 gene
    1 SIMAP similar gene for WDR19 using alignment to 9 protein entries:     WDR19_HUMAN (see all proteins):
    FZR1

    WDR19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR19 (see all 1995)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0673144
    Cranioectodermal dysplasia 4 (CED4)4--see VAR_0673142 L S mis40--------
    VAR_0673124
    Asphyxiating thoracic dystrophy 5 (ATD5)4--see VAR_0673122 L P mis40--------
    VAR_0673134
    Nephronophthisis 13 (NPHP13)4--see VAR_0673132 V G mis40--------
    rs68395111,2
    C,A--38512460(+) TTGTTT/GTTTTT 1 -- int15Minor allele frequency- G:0.00NA WA 10
    rs1114492361,2
    C--38512460(+) TTGTT-/G/TG  
            
    TTTTT
    1 -- int11CSA 2
    rs1128138391,2
    F--38515465(+) ACCACG/ACCCAG 1 -- int12Minor allele frequency- A:0.03CSA WA 120
    rs113724831,2
    C--38521944(+) AAAAC-/AAAACA 1 -- int10--------
    rs790857091,2
    C--38523997(+) AAAAAG/AAAAAG 1 -- int12Minor allele frequency- A:0.33NA CSA 3
    rs343592311,2
    C--38552690(+) AATAT-/ACACAAG 1 -- int10--------
    rs1121213051,2
    C--38557003(+) ACTTA-/CCTCTG 1 -- int11Minor allele frequency- C:0.00CSA 2

    HapMap Linkage Disequilibrium report for WDR19 (39184024 - 39287430 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WDR19:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2424590CNV Deletion19546169
    esv2615856CNV Deletion19546169
    nsv878940CNV Gain21882294

    Human Gene Mutation Database (HGMD): WDR19
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR19
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608151   
    OMIM disorders: 614377  614378  614376  
    UniProtKB/Swiss-Prot: WDR19_HUMAN, Q8NEZ3
  • Cranioectodermal dysplasia 4 (CED4) [MIM:614378]: A disorder primarily characterized by craniofacial,
    skeletal and ectodermal abnormalities. Clinical features include craniosynostosis, narrow rib cage, short limbs,
    brachydactyly, hypoplastic and widely spaced teeth, sparse hair, skin laxity and abnormal nails. Nephronophthisis
    leading to progressive renal failure, hepatic fibrosis, heart defects, and retinitis pigmentosa have also been
    described. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Asphyxiating thoracic dystrophy 5 (ATD5) [MIM:614376]: An autosomal recessive chondrodysplasia
    characterized by a severely constricted thoracic cage, short-limbed short stature, and polydactyly. It often
    leads to death in infancy because of respiratory insufficiency. Retinal degeneration, cystic renal disease and
    hepatic disease can be present in affected individuals who survive early childhood. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Nephronophthisis 13 (NPHP13) [MIM:614377]: An autosomal recessive disorder resulting in end-stage renal
    disease. It is a progressive tubulo-interstitial kidney disorder histologically characterized by modifications of
    the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages,
    medullary cysts. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for WDR19 (see all 28):    
    About MalaCards
    nephronophthisis 13    cranioectodermal dysplasia 4    asphyxiating thoracic dystrophy    asphyxiating thoracic dystrophy 5
    juvenile autosomal recessive medullary cystic kidney disease    asphyxiating thoracic dystrophy 2    cranioectodermal dysplasia 1    sensenbrenner syndrome
    ellis-van creveld syndrome    nephronophthisis    bardet-biedl syndrome    craniosynostosis
    brachydactyly    chondrodysplasia    polydactyly    prostate adenocarcinoma
    short stature    retinal degeneration    retinitis pigmentosa    retinitis

    5 diseases from the University of Copenhagen DISEASES database for WDR19:
    Sensenbrenner syndrome     Asphyxiating thoracic dystrophy     Polydactyly     Bardet-Biedl syndrome
    Ellis-Van Creveld syndrome

    WDR19 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WDR19

    Export disorders for WDR19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR19 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with WDR19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human and mouse WDR19,a novel WD- repeat protein exhibiting androgen-regulated expression in prostate epithelium. (PubMed id 12906858)1, 2, 3, 9 Lin B.... Nelson P.S. (Genomics 2003)
    2. Ciliopathies with skeletal anomalies and renal insufficiency due to mutations in the IFT-A gene WDR19. (PubMed id 22019273)1, 2, 3 Bredrup C.... Arts H.H. (Am. J. Hum. Genet. 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    6. Identification of 99 novel mutations in a worldwide cohort of 1,056 patients with a nephronophthisis-related ciliopathy. (PubMed id 23559409)1 Halbritter J....Otto E.A. (Hum. Genet. 2013)
    7. WDR19: an ancient, retrograde, intraflagellar ciliary protein is mutated in autosomal recessive retinitis pigmentosa and in Senior-Loken syndrome. (PubMed id 23683095)1 Coussa R.G....Koenekoop R.K. (Clin. Genet. 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. (PubMed id 20889716)2 Mukhopadhyay S....Jackson P.K. (Genes Dev. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57728 HGNC: 18340 AceView: WDR19 Ensembl:ENSG00000157796 euGenes: HUgn57728
    ECgene: WDR19 H-InvDB: WDR19

    (According to HUGE)
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    HUGE: KIAA1638

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WDR19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDR19 gene:
    Search GeneIP for patents involving WDR19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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