WDR18 Gene
protein-coding GIFtS: 47
GCID: GC19P000983
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|
WD repeat domain 18
| |
Aliases
for WDR18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 181 2 | | Ipi31 2 | | R32184_12 | | Involved In Processing ITS2 3 Homolog2 | | WD Repeat-Containing Protein 182 |
Export aliases for WDR18 gene to outside databasesPrevious GC identifers: GC19P001059 GC19P000924 GC19P000935 GC19P000757 |
Summaries
for WDR18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WDR18:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric ormultiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycleprogression, signal transduction, apoptosis, and gene regulation. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: WDR18_HUMAN, Q9BV38Function: May play a role during development (By similarity). Functions as a component of the Five Friends ofMethylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylationof ZNF148 and subsequent transactivation of ZNF148 target genes
|
Genomic Views
for WDR18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR18 gene promoter:
Pax-5 AP-4 XBP-1 NF-E2 p45 Roaz CREB Max deltaCREB NF-E2
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR18
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR18 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3WDR18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P000983: view genomic region
(about GC identifiers)
Start:
|
983,174 bp from pter |
End:
|
994,569 bp from pter |
Size:
|
11,396 bases |
Orientation:
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plus strand |
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Proteins
for WDR18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR18_HUMAN, Q9BV38 (See
protein sequence)Recommended Name: WD repeat-containing protein 18 Size: 432 amino acids; 47405 Da
Subunit: Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complexinteracts with methylated CHTOP and ZNF148. Interacts with NOL9
Subcellular location: Nucleus, nucleoplasm (By similarity). Cytoplasm (By similarity). Note=Mainly found in thenucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity)
Sequence caution: Sequence=AAC12679.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O60390 Q9BWR2Explore the universe of human proteins at neXtProt for WDR18: NX_Q9BV38
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BV38
WDR18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_077005.2
ENSEMBL proteins: ENSP00000251289 ENSP00000464855 ENSP00000466551 ENSP00000465826
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
WDR18 for ontologies About GeneDecksing
WDR18 Antibody Products:
Assay Products for WDR18: |
Protein
Domains /
Families
for WDR18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR18 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9BV38ProtoNet protein and cluster: Q9BV38 UniProtKB/Swiss-Prot: WDR18_HUMAN, Q9BV38Similarity: Belongs to the WD repeat WDR18 familySimilarity: Contains 6 WD repeats |
Function
for WDR18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: WDR18_HUMAN, Q9BV38Function: May play a role during development (By similarity). Functions as a component of the Five Friends ofMethylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylationof ZNF148 and subsequent transactivation of ZNF148 target genes
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR18
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR18 |
1 GenomeRNAi human phenotype for WDR18:
|
Pathways & Interactions
for WDR18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR18
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/821 Interacting proteins for WDR18 (Q9BV382, 3 ENSP000002512894) via UniProtKB, MINT, STRING, and/or I2D (see all 821)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- |
WDR18 for ontologies About GeneDecksing
|
Drugs & Compounds
for WDR18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR18
Search CenterWatch for drugs/clinical trials and news about WDR18
|
Transcripts
for WDR18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR18 gene: NM_024100.3 Unigene Cluster for WDR18: WD repeat domain 18 Hs.325321 [show with all ESTs]Unigene Representative Sequence: BM92663310 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000591997 ENST00000251289(uc002lqm.1) ENST00000587001 ENST00000586317
ENST00000591985 ENST00000585809 ENST00000590397 ENST00000591276 ENST00000590354
ENST00000591155
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR18 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR18
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WDR18 (NM_024100) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR18 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR18 |
Additional cDNA sequence: AK131009.1 BC000040.2 BC001648.2 12 DOTS entries: DT.443351 DT.100845755 DT.100774050 DT.100800787 DT.99989034 DT.100809072 DT.97850263 DT.121426274 DT.95294375 DT.100805989 DT.95327949 DT.100695552 24/368 AceView cDNA sequences (see all 368): BX366424 AI254728 AI569540 CR592965 BX433837 BM973198 AA552620 BM469518 AW327564 CR622581 AW248802 CR594394 CR599979 BM555331 BG178818 BQ436374 CR611615 CR598079 CR595734 BX372649 CR596996 AL558380 CR617758 BU154887
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for WDR18 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for WDR18
|
Expression
for WDR18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTCCCAGCA
About this image
See WDR18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR18
SOURCE GeneReport for Unigene cluster: Hs.325321
SABiosciences Custom PCR Arrays for WDR18
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR18
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR18 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR18 |
Orthologs
for WDR18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WDR18 gene from 9/26 species (see all 26) About this table
ENSEMBL Gene Tree for WDR18 (if available)
TreeFam Gene Tree for WDR18 (if available) |
Paralogs
for WDR18 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for WDR18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR18 (983174 - 994569 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for WDR18
5 CNVs: 30055 4066 2237 5065 30885
2 Indels: 45819 12009 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR18 |
|
Disorders
/ Diseases
for WDR18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for WDR18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR18 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with WDR18) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- LAS1L interacts with the mammalian Rix1 complex to reg ulate ribosome biogenesis. (PubMed id 22190735)1, 3 Castle C.D....Denicourt C. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Five Friends of Methylated Chtop, a complex linking arginine methylation to desumoylation. (PubMed id 22872859)2 Fanis P....van Dijk T.B. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Maintenance of silent chromatin through replication r equires SWI/SNF-like chromatin remodeler SMARCAD1. (PubMed id 21549307)1 Rowbotham S.P....Mermoud J.E. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for WDR18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR18 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR18 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR18 gene:
Search GeneIP for patents involving WDR18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR18 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR18 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR18 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR18 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR18 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR18 |
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