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Aliases for WDR18 Gene

Aliases for WDR18 Gene

  • WD Repeat Domain 18 2 3
  • Involved In Processing ITS2 3 Homolog (S. Cerevisiae) 2
  • Involved In Processing ITS2 3 Homolog 3
  • WD Repeat-Containing Protein 18 3
  • R32184_1 3
  • Ipi3 3

External Ids for WDR18 Gene

Summaries for WDR18 Gene

Entrez Gene Summary for WDR18 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR18 Gene

WDR18 (WD Repeat Domain 18) is a Protein Coding gene.

UniProtKB/Swiss-Prot for WDR18 Gene

  • May play a role during development (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR18 Gene

Genomics for WDR18 Gene

Genomic Location for WDR18 Gene

984,271 bp from pter
998,438 bp from pter
14,168 bases
Plus strand

Genomic View for WDR18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR18 Gene

Regulatory Elements for WDR18 Gene

Proteins for WDR18 Gene

  • Protein details for WDR18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 18
    Protein Accession:
    Secondary Accessions:
    • O60390
    • Q9BWR2

    Protein attributes for WDR18 Gene

    432 amino acids
    Molecular mass:
    47405 Da
    Quaternary structure:
    • Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9.
    • Sequence=AAC12679.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for WDR18 Gene

Proteomics data for WDR18 Gene at MOPED

Post-translational modifications for WDR18 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys301 and Lys389

No data available for DME Specific Peptides for WDR18 Gene

Domains for WDR18 Gene

Gene Families for WDR18 Gene

  • WDR :WD repeat domain containing


  • Belongs to the WD repeat WDR18 family.:
    • Q9BV38
  • Contains 6 WD repeats.:
    • Q9BV38
genes like me logo Genes that share domains with WDR18: view

Function for WDR18 Gene

Molecular function for WDR18 Gene

UniProtKB/Swiss-Prot Function: May play a role during development (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

Gene Ontology (GO) - Molecular Function for WDR18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21326211
genes like me logo Genes that share ontologies with WDR18: view

Phenotypes for WDR18 Gene

GenomeRNAi human phenotypes for WDR18:
genes like me logo Genes that share phenotypes with WDR18: view

miRNA for WDR18 Gene

miRTarBase miRNAs that target WDR18

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDR18 Gene

Localization for WDR18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR18 Gene

Nucleus, nucleoplasm. Cytoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for WDR18 Gene COMPARTMENTS Subcellular localization image for WDR18 gene
Compartment Confidence
nucleus 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for WDR18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with WDR18: view

Pathways for WDR18 Gene

SuperPathways for WDR18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with WDR18: view

No data available for Pathways by source for WDR18 Gene

Transcripts for WDR18 Gene

mRNA/cDNA for WDR18 Gene

Unigene Clusters for WDR18 Gene

WD repeat domain 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR18 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: -
SP3: - - - - -
SP4: - - -

Relevant External Links for WDR18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR18 Gene

mRNA expression in normal human tissues for WDR18 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR18 Gene

SOURCE GeneReport for Unigene cluster for WDR18 Gene Hs.325321

genes like me logo Genes that share expressions with WDR18: view

Orthologs for WDR18 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR18 36
  • 94.72 (n)
  • 93.53 (a)
WDR18 37
  • 99 (a)
(Bos Taurus)
Mammalia WDR18 36
  • 86.88 (n)
  • 90.05 (a)
WDR18 37
  • 90 (a)
(Canis familiaris)
Mammalia WDR18 36
  • 88.52 (n)
  • 89.81 (a)
WDR18 37
  • 90 (a)
(Mus musculus)
Mammalia Wdr18 36
  • 83.29 (n)
  • 83.53 (a)
Wdr18 16
Wdr18 37
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia WDR18 37
  • 69 (a)
(Rattus norvegicus)
Mammalia Wdr18 36
  • 82.99 (n)
  • 83.29 (a)
(Gallus gallus)
Aves WDR18 36
  • 75.36 (n)
  • 75.27 (a)
WDR18 37
  • 72 (a)
(Anolis carolinensis)
Reptilia WDR18 37
  • 69 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5262 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6423 36
wdr18 36
  • 64.09 (n)
  • 64.87 (a)
(Danio rerio)
Actinopterygii wdr18 36
  • 64.19 (n)
  • 61.16 (a)
wdr18 37
  • 61 (a)
wufa16f06 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000479 36
  • 52.96 (n)
  • 38.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14805 36
  • 50.4 (n)
  • 35.76 (a)
CG14805 37
  • 26 (a)
EG:63B12.7 38
  • 32 (a)
(Caenorhabditis elegans)
Secernentea pro-1 36
  • 35.16 (n)
  • 25.48 (a)
pro-1 37
  • 19 (a)
R166.4 38
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IPI3 39
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8986 37
  • 32 (a)
Species with no ortholog for WDR18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR18 Gene

Gene Tree for WDR18 (if available)
Gene Tree for WDR18 (if available)

Paralogs for WDR18 Gene

Selected SIMAP similar genes for WDR18 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with WDR18: view

No data available for Paralogs for WDR18 Gene

Variants for WDR18 Gene

Sequence variations from dbSNP and Humsavar for WDR18 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1127043 -- 991,968(+) ACCAA(C/T)GCCGC synonymous-codon, reference
rs2074573 -- 985,815(+) TGTAG(G/T)AGCTC intron-variant
rs2074574 -- 985,997(+) GTGAG(C/G)GTTTC intron-variant
rs2158367 - 990,281(+) ACCAC(A/G)CGCTC missense, reference
rs2240147 -- 989,730(+) TTCCT(A/C)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR18 Gene

Variant ID Type Subtype PubMed ID
nsv470101 CNV Loss 18288195
dgv3513n71 CNV Loss 21882294
dgv3550n71 CNV Loss 21882294
dgv3552n71 CNV Loss 21882294
nsv910292 CNV Loss 21882294
nsv910310 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
dgv3560n71 CNV Loss 21882294
dgv3561n71 CNV Loss 21882294
nsv9662 CNV Gain 18304495
dgv3564n71 CNV Loss 21882294
dgv3565n71 CNV Loss 21882294
dgv3566n71 CNV Loss 21882294
nsv469845 CNV Loss 16826518
essv258 CNV CNV 17122850
nsv833704 CNV Gain 17160897
dgv1055e1 CNV Complex 17122850
nsv910361 CNV Gain+Loss 21882294
dgv3567n71 CNV Loss 21882294
dgv3568n71 CNV Loss 21882294
dgv3569n71 CNV Loss 21882294
esv2717815 CNV Deletion 23290073
esv2145472 CNV Deletion 18987734
esv2717816 CNV Deletion 23290073
esv2717817 CNV Deletion 23290073
nsv138364 CNV Loss 16902084
nsv910370 CNV Loss 21882294
dgv3570n71 CNV Loss 21882294

Relevant External Links for WDR18 Gene

HapMap Linkage Disequilibrium report

Disorders for WDR18 Gene

No disorders were found for WDR18 Gene.

No data available for UniProtKB/Swiss-Prot for WDR18 Gene

Publications for WDR18 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis. (PMID: 22190735) Castle C.D. … Denicourt C. (Mol. Biol. Cell 2012) 2 3
  4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  5. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PMID: 22586326) Tsai Y.C. … Cristea I.M. (Mol. Cell. Proteomics 2012) 3

Products for WDR18 Gene

Sources for WDR18 Gene

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