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Aliases for WDR18 Gene

Aliases for WDR18 Gene

  • WD Repeat Domain 18 2 3 5
  • Involved In Processing ITS2 3 Homolog (S. Cerevisiae) 2
  • Involved In Processing ITS2 3 Homolog 3
  • WD Repeat-Containing Protein 18 3
  • R32184_1 3
  • Ipi3 3

External Ids for WDR18 Gene

Previous GeneCards Identifiers for WDR18 Gene

  • GC19P001059
  • GC19P000924
  • GC19P000935
  • GC19P000757

Summaries for WDR18 Gene

Entrez Gene Summary for WDR18 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR18 Gene

WDR18 (WD Repeat Domain 18) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression.

UniProtKB/Swiss-Prot for WDR18 Gene

  • May play a role during development (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR18 Gene

Genomics for WDR18 Gene

Regulatory Elements for WDR18 Gene

Enhancers for WDR18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F000982 0.4 ENCODE 77.2 -0.2 -195 3.2 HDGF ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 WDR18 ENSG00000266990 RNA5SP462 CFD CIRBP FSTL3 MIDN GC19P000978
GH19F000985 0.6 ENCODE 74.2 +1.5 1525 0.2 WDR18 PIR49775
GH19F000995 1.7 FANTOM5 Ensembl ENCODE 65.5 +11.9 11939 1.5 ATF1 GLI4 ZNF2 GLIS2 ZNF416 KLF7 FOS PAF1 SP3 YY2 WDR18 MIER2 GZMM LOC100288123 ENSG00000267317 TMEM259 C19orf24 SCAMP4 GRIN3B ARHGAP45
GH19F000992 0.2 ENCODE 62.8 +9.0 8971 1.5 TBP ELF3 MLX ARID4B DMAP1 THRB ZNF48 ZSCAN9 RARA YY1 WDR18 GC19M000980 PIR49775
GH19F001019 0.2 ENCODE 22 +36.9 36937 4.4 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SP3 LOC100288123 TMEM259 ENSG00000267317 GRIN3B MIER2 ABCA7 ENSG00000261526 CIRBP WDR18 ENSG00000266990
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around WDR18 on UCSC Golden Path with GeneCards custom track

Promoters for WDR18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000042248 329 1201 HDGF ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9
ENSR00001815104 -1371 601 HDGF CREB3L1 ARID4B SIN3A ZNF48 ZNF766 GLIS2 ZNF207 ZNF143 KLF7

Genomic Location for WDR18 Gene

Chromosome:
19
Start:
984,271 bp from pter
End:
998,438 bp from pter
Size:
14,168 bases
Orientation:
Plus strand

Genomic View for WDR18 Gene

Genes around WDR18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR18 Gene

Proteins for WDR18 Gene

  • Protein details for WDR18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV38-WDR18_HUMAN
    Recommended name:
    WD repeat-containing protein 18
    Protein Accession:
    Q9BV38
    Secondary Accessions:
    • O60390
    • Q9BWR2

    Protein attributes for WDR18 Gene

    Size:
    432 amino acids
    Molecular mass:
    47405 Da
    Quaternary structure:
    • Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9.
    SequenceCaution:
    • Sequence=AAC12679.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for WDR18 Gene

Post-translational modifications for WDR18 Gene

  • Ubiquitination at Lys 301 and Lys 389
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WDR18 Gene

Domains & Families for WDR18 Gene

Suggested Antigen Peptide Sequences for WDR18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BV38

UniProtKB/Swiss-Prot:

WDR18_HUMAN :
  • Belongs to the WD repeat WDR18 family.
  • Contains 6 WD repeats.
Family:
  • Belongs to the WD repeat WDR18 family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR18: view

Function for WDR18 Gene

Molecular function for WDR18 Gene

UniProtKB/Swiss-Prot Function:
May play a role during development (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

Gene Ontology (GO) - Molecular Function for WDR18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21326211
genes like me logo Genes that share ontologies with WDR18: view
genes like me logo Genes that share phenotypes with WDR18: view

Animal Model Products

miRNA for WDR18 Gene

miRTarBase miRNAs that target WDR18

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR18 Gene

Localization for WDR18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR18 Gene

Nucleus, nucleoplasm. Cytoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR18 Gene COMPARTMENTS Subcellular localization image for WDR18 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for WDR18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with WDR18: view

Pathways & Interactions for WDR18 Gene

genes like me logo Genes that share pathways with WDR18: view

Gene Ontology (GO) - Biological Process for WDR18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with WDR18: view

No data available for SIGNOR curated interactions for WDR18 Gene

Transcripts for WDR18 Gene

Unigene Clusters for WDR18 Gene

WD repeat domain 18:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR18 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: -
SP3: - - - - -
SP4: - - -
SP5:
SP6:

Relevant External Links for WDR18 Gene

GeneLoc Exon Structure for
WDR18
ECgene alternative splicing isoforms for
WDR18

Expression for WDR18 Gene

mRNA expression in normal human tissues for WDR18 Gene

Protein differential expression in normal tissues from HIPED for WDR18 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.1) and Fetal ovary (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR18 Gene



Protein tissue co-expression partners for WDR18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR18 Gene:

WDR18

SOURCE GeneReport for Unigene cluster for WDR18 Gene:

Hs.325321
genes like me logo Genes that share expression patterns with WDR18: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR18 Gene

Orthologs for WDR18 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR18 34 35
  • 94.72 (n)
dog
(Canis familiaris)
Mammalia WDR18 34 35
  • 88.52 (n)
cow
(Bos Taurus)
Mammalia WDR18 34 35
  • 86.88 (n)
mouse
(Mus musculus)
Mammalia Wdr18 34 16 35
  • 83.29 (n)
rat
(Rattus norvegicus)
Mammalia Wdr18 34
  • 82.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR18 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR18 34 35
  • 75.36 (n)
lizard
(Anolis carolinensis)
Reptilia WDR18 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr18 34
  • 64.09 (n)
Str.6423 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.5262 34
zebrafish
(Danio rerio)
Actinopterygii wdr18 34 35
  • 64.19 (n)
wufa16f06 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000479 34
  • 52.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14805 34 35
  • 50.4 (n)
EG:63B12.7 36
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea pro-1 34 35
  • 35.16 (n)
R166.4 36
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IPI3 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8986 35
  • 32 (a)
OneToOne
Species where no ortholog for WDR18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR18 Gene

ENSEMBL:
Gene Tree for WDR18 (if available)
TreeFam:
Gene Tree for WDR18 (if available)

Paralogs for WDR18 Gene

(2) SIMAP similar genes for WDR18 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with WDR18: view

No data available for Paralogs for WDR18 Gene

Variants for WDR18 Gene

Sequence variations from dbSNP and Humsavar for WDR18 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10403847 -- 981,722(+) gaggt(C/T)gaagt upstream-variant-2KB
rs10404706 -- 987,051(+) AAAAA(A/G)GCCAC intron-variant
rs10405599 -- 986,825(+) AGCTG(C/T)GGCGT intron-variant
rs10409367 -- 990,185(+) CCTCC(C/G)CTCCC intron-variant
rs10413618 -- 981,462(+) gactc(A/C)atttc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WDR18 Gene

Variant ID Type Subtype PubMed ID
esv2145472 CNV deletion 18987734
esv2717815 CNV deletion 23290073
esv2717816 CNV deletion 23290073
esv2717817 CNV deletion 23290073
esv2758743 CNV gain+loss 17122850
esv3643380 CNV loss 21293372
esv3643381 CNV gain 21293372
nsv1160555 CNV deletion 26073780
nsv138364 CNV deletion 16902084
nsv469845 CNV loss 16826518
nsv470101 CNV loss 18288195
nsv578188 CNV loss 21841781
nsv833704 CNV gain 17160897
nsv953938 CNV deletion 24416366
nsv9662 CNV gain 18304495

Variation tolerance for WDR18 Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.35; 85.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR18 Gene

Disorders for WDR18 Gene

Relevant External Links for WDR18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR18

No disorders were found for WDR18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR18 Gene

Publications for WDR18 Gene

  1. LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis. (PMID: 22190735) Castle C.D. … Denicourt C. (Mol. Biol. Cell 2012) 2 3 64
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64
  5. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3 64

Products for WDR18 Gene

Sources for WDR18 Gene

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