V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

WDR18 Gene

protein-coding GIFtS: 51

GC19P000935

WD repeat domain 18
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC2436 ^²
R32184_1 ^²

Descriptions
WD repeat domain 18 ^²

External Ids
HGNC: 17956¹
Entrez Gene: 57418²
UniProtKB: Q9BV38³
Ensembl: ENSG00000065268⁷

Search outside databases for aliases for WDR18 gene

Previous GC identifers: GC19P001059 GC19P000924

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for WDR18:

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved

regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which

may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are

involved in a variety of cellular processes, including cell cycle progression, signal

transduction, apoptosis, and gene regulation. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the WDR18 gene

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

WDR18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P000935: (about GC identifiers)

Start:	935,328 bp from pter
End:	945,569 bp from pter
Size:	10,242 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011255.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: WDR18_HUMAN, Q9BV38 (See protein sequence)

Recommended Name: WD repeat-containing protein 18

Size: 432 amino acids; 47405 Da

Secondary accessions: O60390 Q9BWR2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_077005.2

ENSEMBL proteins:

ENSP00000251289

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich AQUA Peptides for WDR18
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (WDR18)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for WDR18:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for WDR18
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Monoclonal and Polyclonal Antibodies from Abnova (WDR18)
	Novus Biologicals Antibody for WDR18

Assays for WDR18:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9BV38

ProtoNet protein and cluster: Q9BV38

UniProtKB/Swiss-Prot: WDR18_HUMAN, Q9BV38

Similarity: Contains 6 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR18)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024100

Applied Biosystems Silencer® siRNAs for WDR18

Sigma-Aldrich siRNA for WDR18

Sigma-Aldrich shRNA for WDR18

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for WDR18
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_024100
Myc/DDK tagged cDNA clone in CMV expression vector: NM_024100
untagged cDNA clones in CMV expression vector (see all 2): NM_024100

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_024100

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/235 Interacting proteins for WDR18 (Q9BV38²) via UniProtKB, MINT, and/or STRING (see all 235 )
Interactant Interaction Details
GeneCard External ID(s)
ATAD3B Q5T9A4² MINT-6488791
C4orf14 Q8NC60² MINT-65365
COPA P53621² MINT-6488791
DDX18 Q9NVP1² MINT-6488791
DDX39 O00148² MINT-6488791
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR18

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR18)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024100

Sigma-Aldrich siRNA for WDR18

Sigma-Aldrich shRNA for WDR18

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_024100

REFSEQ mRNAs for WDR18 gene:

NM_024100.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_024100

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024100
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024100
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_024100

Additional cDNA sequence:

AK131009.1 BC000040.2 BC001648.2 CR592965.1 CR593523.1 CR594394.1 CR595453.1 CR595734.1

CR596996.1 CR598079.1 CR598373.1 CR599695.1 CR599979.1 CR602625.1 CR606441.1 CR607398.1

CR608369.1 CR608621.1 CR611615.1 CR613038.1 CR615734.1 CR616693.1 CR616757.1 CR617758.1

CR620331.1 CR621568.1 CR621572.1 CR622581.1 CR622892.1 CR623880.1 CR625348.1 CR626487.1

12 DOTS entries:

DT.443351 DT.100845755 DT.100774050 DT.100800787 DT.99989034 DT.100809072 DT.97850263 DT.121426274

DT.95294375 DT.100805989 DT.95327949 DT.100695552

24/368 AceView cDNA sequences (see all 368 ):

AA767538 AW050733 CR602625 CR613038 CR616757 CR623880 BI754706 CR608621

BM971677 BU857861 BM918561 CR594394 CR617758 AW029134 CR599979 AW327564

CR622581 BQ436374 BX366424 BU154887 CR593523 CA432033 AW248802 AA552620

highest scoring ESTs for WDR18:

AA053559 AA102434 AA133100 AA155594 AA279315 AA279371 AA552254 AA552297 AA552620 AA565521

Unigene Cluster for WDR18:

WD repeat domain 18

Hs.325321 [show with all ESTs]

Unigene Representative Sequence: BM926633

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for WDR18 (see all 6 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12
SP1:																	-		-						-
SP2:																									-
SP3:					-		-		-								-		-
SP4:									-								-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for WDR18

1 Ensembl transcript including schematic representation:

ENST00000251289

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR18 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for WDR18

¹ / ² / ³

3 probe-sets matching WDR18 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35983_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AC004528	0.20	0.50	0.38	1
209461_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC001648	0.80	1.00	0.91	1
209461_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTCCCAGCA

SOURCE GeneReport for Unigene cluster: Hs.325321
Expression variation in blood from EXPOLDB for WDR18

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WDR18 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WDR18¹	--	WD repeat domain 18	88.52(n) 89.81(a)	612368 XM_850098.1 XP_855191.1
cow (Bos taurus)	WDR18¹	--	WD repeat domain 18	86.88(n) 90.05(a)	533356 NM_001034588.1 NP_001029760.1
rat (Rattus norvegicus)	Wdr18¹	--	WD repeat domain 18	82.99(n) 83.29(a)	314617 NM_001039027.1 NP_001034116.1
mouse (Mus musculus)	Wdr18^{1, 5}	10⁵	WD repeat domain 18^{1, 5}	83.29(n)¹ 83.53(a)¹	216156¹ NM_175450.4¹ NP_780659.2¹ AA474698⁵ AC087114⁵ (see all 25)
zebrafish (Danio rerio)	wufa16f06²	--	Transcribed sequence with weak similarity to protein more	72(n)	CF347234.1

About this table Species with no ortholog for WDR18

ENSEMBL Gene Tree for WDR18

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/128 NCBI SNPs in WDR18 are shown (see all 128 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 52)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2158367^1,2	C,F,H	941281(+)	`ACCACA/GCGCTC`	1	A/T	mis¹ ese³		6		EA EU WA NA	1786
	rs8112598^1,2	A,C	935218(+)	`AAAGCC/TCCTCT`	1	--	ng5¹ trp³		0	--	--	--	--
--	rs8109453^1,2	A,C	945800(+)	`GCTGGA/GCCGGG`	1	--	ng3¹		0	--	--	--	--
	rs11538683^1,2	C,F	942129(+)	`GGAAGG/ATCTTC`	1	I/V	mis¹		1		NA	74
--	rs8109460^1,2	A,C	945814(+)	`GTGGGA/GTTGAG`	1	--	ng3¹		0	--	--	--	--
	rs35068100^1,2	F	941891(-)	`AAAGAG/AGACGG`	1	F/L	mis¹		1		NA	74
--	rs8106918^1,2	A	945813(+)	`GGTGGG/TATTGA`	1	--	ng3¹		0	--	--	--	--
	rs2301810^1,2	A,C,F,H	935533(+)	`AAGAAT/CTACAT`	1	N/N	syn¹ ese³		5		MN EU EA WA	590
	rs4806884^1,2	A,C,F,H	935554(+)	`GAGCTC/GCAGCG`	1	L/L	syn¹		5		MN EU EA WA	594
--	rs1127043^1,2	C,F	942968(+)	`ACCAAT/CGCCGC`	1	N/N	syn¹ ese³		1		EA	1296

About this table

HapMap Linkage Disequilibrium images for WDR18 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for WDR18 gene:

The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{3, 4} Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. (PubMed id 18083107)⁴ Rikova K....Comb M.J. (2007)
Nucleolar proteome dynamics. (PubMed id 15635413)³ Andersen J.S....Mann M. (2005)
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. (PubMed id 12086872)⁷ Yeoh E.J....Downing J.R. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Directed proteomic analysis of the human nucleolus. (PubMed id 11790298)³ Andersen J.S.... Lamond A.I. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 57418	HGNC: 17956	AceView: WDR18	Ensembl:ENSG00000065268	euGenes: HUgn57418
ECgene: WDR18	H-InvDB: WDR18

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for WDR18
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for WDR18:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for WDR18-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for WDR18		Antibodies for WDR18
	Explore super-pooled esiRNAs		Proteins for WDR18
	Lentivirus-delivered shRNAs for WDR18		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (WDR18)
	Antibodies (WDR18)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Search for Recombinant Proteins
	Search for Antibodies

Search OriGene for WDR18

Search Tocris compounds for WDR18

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for WDR18

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
WDR18 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

WDR18 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for WDR18

Summaries
for WDR18

Genomic Location
for WDR18

Proteins
for WDR18

Protein Domains/
Families
for WDR18

Gene Function
for WDR18

Pathways & Interactions
for WDR18

Drugs & Compounds
for WDR18

Transcripts
for WDR18

Expression
for WDR18

Orthologs
for WDR18

Paralogs
for WDR18

SNPs/Variants
for WDR18

Disorders & Mutations
for WDR18

Medical News
for WDR18

Publications
for WDR18

Search for WDR18

Genome Databases showing WDR18

Other Databases showing WDR18

Specialized Databases showing WDR18

Licensable Technologies
for WDR18

Services
for WDR18

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WDR18 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor WDR18

Summariesfor WDR18

Genomic Locationfor WDR18

Proteinsfor WDR18

Protein Domains/Familiesfor WDR18

Gene Functionfor WDR18

Pathways & Interactionsfor WDR18

Drugs & Compoundsfor WDR18

Transcriptsfor WDR18

Expression for WDR18

Orthologsfor WDR18

Paralogsfor WDR18

SNPs/Variantsfor WDR18

Disorders & Mutationsfor WDR18

Medical Newsfor WDR18

Publicationsfor WDR18

Search for WDR18

Genome Databases showing WDR18

Other Databases showing WDR18

Specialized Databases showing WDR18

Licensable Technologiesfor WDR18

Servicesfor WDR18

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for WDR18

Summaries
for WDR18

Genomic Location
for WDR18

Proteins
for WDR18

Protein Domains/
Families
for WDR18

Gene Function
for WDR18

Pathways & Interactions
for WDR18

Drugs & Compounds
for WDR18

Transcripts
for WDR18

Expression
for WDR18

Orthologs
for WDR18

Paralogs
for WDR18

SNPs/Variants
for WDR18

Disorders & Mutations
for WDR18

Medical News
for WDR18

Publications
for WDR18

Licensable Technologies
for WDR18

Services
for WDR18