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Aliases for WDR18 Gene

Aliases for WDR18 Gene

  • WD Repeat Domain 18 2 3 5
  • Involved In Processing ITS2 3 Homolog (S. Cerevisiae) 2
  • Involved In Processing ITS2 3 Homolog 3
  • R32184_1 3
  • Ipi3 3

External Ids for WDR18 Gene

Previous GeneCards Identifiers for WDR18 Gene

  • GC19P001059
  • GC19P000924
  • GC19P000935
  • GC19P000757

Summaries for WDR18 Gene

Entrez Gene Summary for WDR18 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR18 Gene

WDR18 (WD Repeat Domain 18) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing.

UniProtKB/Swiss-Prot for WDR18 Gene

  • May play a role during development (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR18 Gene

Genomics for WDR18 Gene

Regulatory Elements for WDR18 Gene

Enhancers for WDR18 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR18 on UCSC Golden Path with GeneCards custom track

Promoters for WDR18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR18 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR18 Gene

Chromosome:
19
Start:
984,271 bp from pter
End:
998,438 bp from pter
Size:
14,168 bases
Orientation:
Plus strand

Genomic View for WDR18 Gene

Genes around WDR18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR18 Gene

Proteins for WDR18 Gene

  • Protein details for WDR18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV38-WDR18_HUMAN
    Recommended name:
    WD repeat-containing protein 18
    Protein Accession:
    Q9BV38
    Secondary Accessions:
    • O60390
    • Q9BWR2

    Protein attributes for WDR18 Gene

    Size:
    432 amino acids
    Molecular mass:
    47405 Da
    Quaternary structure:
    • Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9.
    SequenceCaution:
    • Sequence=AAC12679.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for WDR18 Gene

Proteomics data for WDR18 Gene at MOPED

Post-translational modifications for WDR18 Gene

  • Ubiquitination at Lys 301 and Lys 389
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for WDR18
  • Santa Cruz Biotechnology (SCBT) Antibodies for WDR18

No data available for DME Specific Peptides for WDR18 Gene

Domains & Families for WDR18 Gene

Gene Families for WDR18 Gene

Suggested Antigen Peptide Sequences for WDR18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BV38

UniProtKB/Swiss-Prot:

WDR18_HUMAN :
  • Belongs to the WD repeat WDR18 family.
  • Contains 6 WD repeats.
Family:
  • Belongs to the WD repeat WDR18 family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR18: view

Function for WDR18 Gene

Molecular function for WDR18 Gene

UniProtKB/Swiss-Prot Function:
May play a role during development (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
genes like me logo Genes that share phenotypes with WDR18: view

Animal Model Products

miRNA for WDR18 Gene

miRTarBase miRNAs that target WDR18

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR18 Gene

Localization for WDR18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR18 Gene

Nucleus, nucleoplasm. Cytoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR18 Gene COMPARTMENTS Subcellular localization image for WDR18 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for WDR18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with WDR18: view

Pathways & Interactions for WDR18 Gene

genes like me logo Genes that share pathways with WDR18: view

Pathways by source for WDR18 Gene

Gene Ontology (GO) - Biological Process for WDR18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with WDR18: view

No data available for SIGNOR curated interactions for WDR18 Gene

Drugs & Compounds for WDR18 Gene

No Compound Related Data Available

Transcripts for WDR18 Gene

Unigene Clusters for WDR18 Gene

WD repeat domain 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR18 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: -
SP3: - - - - -
SP4: - - -
SP5:
SP6:

Relevant External Links for WDR18 Gene

GeneLoc Exon Structure for
WDR18
ECgene alternative splicing isoforms for
WDR18

Expression for WDR18 Gene

mRNA expression in normal human tissues for WDR18 Gene

Protein differential expression in normal tissues from HIPED for WDR18 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.1) and Fetal ovary (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR18 Gene



SOURCE GeneReport for Unigene cluster for WDR18 Gene Hs.325321

genes like me logo Genes that share expression patterns with WDR18: view

Protein tissue co-expression partners for WDR18 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR18 Gene

Orthologs for WDR18 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR18 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR18 35
  • 86.88 (n)
  • 90.05 (a)
WDR18 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR18 35
  • 88.52 (n)
  • 89.81 (a)
WDR18 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr18 35
  • 83.29 (n)
  • 83.53 (a)
Wdr18 16
Wdr18 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR18 35
  • 94.72 (n)
  • 93.53 (a)
WDR18 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr18 35
  • 82.99 (n)
  • 83.29 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR18 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR18 35
  • 75.36 (n)
  • 75.27 (a)
WDR18 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR18 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6423 35
wdr18 35
  • 64.09 (n)
  • 64.87 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5262 35
zebrafish
(Danio rerio)
Actinopterygii wdr18 35
  • 64.19 (n)
  • 61.16 (a)
wufa16f06 35
wdr18 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EG:63B12.7 37
  • 32 (a)
CG14805 35
  • 50.4 (n)
  • 35.76 (a)
CG14805 36
  • 26 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000479 35
  • 52.96 (n)
  • 38.22 (a)
worm
(Caenorhabditis elegans)
Secernentea R166.4 37
  • 24 (a)
pro-1 35
  • 35.16 (n)
  • 25.48 (a)
pro-1 36
  • 19 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IPI3 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8986 36
  • 32 (a)
OneToOne
Species with no ortholog for WDR18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR18 Gene

ENSEMBL:
Gene Tree for WDR18 (if available)
TreeFam:
Gene Tree for WDR18 (if available)

Paralogs for WDR18 Gene

(2) SIMAP similar genes for WDR18 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with WDR18: view

No data available for Paralogs for WDR18 Gene

Variants for WDR18 Gene

Sequence variations from dbSNP and Humsavar for WDR18 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2158367 - 990,281(+) ACCAC(A/G)CGCTC reference, missense
rs35068100 - 990,891(-) AAAGA(A/G)GACGG reference, missense
rs11538683 - 991,129(+) GGAAG(A/G)TCTTC reference, missense
rs7257607 -- 987,741(+) GATGT(C/T)TTAGG intron-variant
rs12981454 -- 985,251(+) GCCTC(C/T)GCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR18 Gene

Variant ID Type Subtype PubMed ID
nsv470101 CNV Loss 18288195
dgv3513n71 CNV Loss 21882294
dgv3550n71 CNV Loss 21882294
dgv3552n71 CNV Loss 21882294
nsv910292 CNV Loss 21882294
nsv910310 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
dgv3560n71 CNV Loss 21882294
dgv3561n71 CNV Loss 21882294
nsv9662 CNV Gain 18304495
dgv3564n71 CNV Loss 21882294
dgv3565n71 CNV Loss 21882294
dgv3566n71 CNV Loss 21882294
nsv469845 CNV Loss 16826518
essv258 CNV CNV 17122850
nsv833704 CNV Gain 17160897
dgv1055e1 CNV Complex 17122850
nsv910361 CNV Gain+Loss 21882294
dgv3567n71 CNV Loss 21882294
dgv3568n71 CNV Loss 21882294
dgv3569n71 CNV Loss 21882294
esv2717815 CNV Deletion 23290073
esv2145472 CNV Deletion 18987734
esv2717816 CNV Deletion 23290073
esv2717817 CNV Deletion 23290073
nsv138364 CNV Loss 16902084
nsv910370 CNV Loss 21882294
dgv3570n71 CNV Loss 21882294

Variation tolerance for WDR18 Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.35; 85.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WDR18 Gene

Disorders for WDR18 Gene

Relevant External Links for WDR18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR18

No disorders were found for WDR18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR18 Gene

Publications for WDR18 Gene

  1. LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis. (PMID: 22190735) Castle C.D. … Denicourt C. (Mol. Biol. Cell 2012) 2 3 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for WDR18 Gene

Sources for WDR18 Gene

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