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Aliases for WDR17 Gene

Aliases for WDR17 Gene

  • WD Repeat Domain 17 2 3
  • EC 2.7.7.8 64
  • EC 6.1.1 64

External Ids for WDR17 Gene

Summaries for WDR17 Gene

Entrez Gene Summary for WDR17 Gene

  • This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis, and is thought to be a candidate gene for retinal disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2009]

GeneCards Summary for WDR17 Gene

WDR17 (WD Repeat Domain 17) is a Protein Coding gene. An important paralog of this gene is PEX7.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR17 Gene

Genomics for WDR17 Gene

Genomic Location for WDR17 Gene

Start:
176,065,834 bp from pter
End:
176,182,828 bp from pter
Size:
116,995 bases
Orientation:
Plus strand

Genomic View for WDR17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR17 Gene

Regulatory Elements for WDR17 Gene

Proteins for WDR17 Gene

  • Protein details for WDR17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZU2-WDR17_HUMAN
    Recommended name:
    WD repeat-containing protein 17
    Protein Accession:
    Q8IZU2
    Secondary Accessions:
    • E7EQX0
    • Q0QD35

    Protein attributes for WDR17 Gene

    Size:
    1322 amino acids
    Molecular mass:
    147703 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BC146812; Type=Frameshift; Positions=268; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR17 Gene

Proteomics data for WDR17 Gene at MOPED

Selected DME Specific Peptides for WDR17 Gene

Post-translational modifications for WDR17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR17 Gene

Domains for WDR17 Gene

Gene Families for WDR17 Gene

HGNC:
  • WDR :WD repeat domain containing

UniProtKB/Swiss-Prot:

WDR17_HUMAN
Similarity:
  • Contains 12 WD repeats.:
    • Q8IZU2
genes like me logo Genes that share domains with WDR17: view

Function for WDR17 Gene

Enzyme Numbers (IUBMB) for WDR17 Gene

Gene Ontology (GO) - Molecular Function for WDR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WDR17: view

miRNA for WDR17 Gene

miRTarBase miRNAs that target WDR17

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDR17 Gene

Localization for WDR17 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR17 Gene COMPARTMENTS Subcellular localization image for WDR17 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for WDR17 Gene

Pathways for WDR17 Gene

SuperPathways for WDR17 Gene

No Data Available

Interacting Proteins for WDR17 Gene

Selected Interacting proteins: Q8IZU2-WDR17_HUMAN for WDR17 Gene via I2D

Symbol External ID(s) Details
ETS1

Gene Ontology (GO) - Biological Process for WDR17 Gene

None

No data available for Pathways by source for WDR17 Gene

Transcripts for WDR17 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for WDR17 Gene

No ASD Table

Relevant External Links for WDR17 Gene

GeneLoc Exon Structure for
WDR17
ECgene alternative splicing isoforms for
WDR17

Expression for WDR17 Gene

mRNA expression in normal human tissues for WDR17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for WDR17 Gene

SOURCE GeneReport for Unigene cluster for WDR17 Gene Hs.532056

genes like me logo Genes that share expressions with WDR17: view

Orthologs for WDR17 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR17 36
  • 99.55 (n)
  • 99.47 (a)
WDR17 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR17 36
  • 88.61 (n)
  • 91.4 (a)
WDR17 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR17 36
  • 89.56 (n)
  • 91.35 (a)
WDR17 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr17 36
  • 86.23 (n)
  • 88.53 (a)
Wdr17 16
Wdr17 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR17 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR17 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr17 36
  • 86.45 (n)
  • 87.75 (a)
chicken
(Gallus gallus)
Aves WDR17 36
  • 79.69 (n)
  • 83.4 (a)
WDR17 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR17 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr17 36
  • 76.51 (n)
  • 85.51 (a)
zebrafish
(Danio rerio)
Actinopterygii wdr17 36
  • 71.66 (n)
  • 81.9 (a)
wdr17 37
  • 81 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEX7 37
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToOne
Species with no ortholog for WDR17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR17 Gene

ENSEMBL:
Gene Tree for WDR17 (if available)
TreeFam:
Gene Tree for WDR17 (if available)

Paralogs for WDR17 Gene

Paralogs for WDR17 Gene

Selected SIMAP similar genes for WDR17 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with WDR17: view

Variants for WDR17 Gene

Sequence variations from dbSNP and Humsavar for WDR17 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs922846 -- 176,126,528(+) GCATC(A/C)GTGGA intron-variant
rs1185564 -- 176,095,523(-) CTGGC(A/C)TAGGA intron-variant, upstream-variant-2KB
rs1385614 -- 176,071,888(+) CTTTC(C/T)GTATC intron-variant
rs1385615 -- 176,072,032(+) GACCT(C/T)ATTCT intron-variant
rs1385616 -- 176,076,622(+) TGATA(C/T)GATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR17 Gene

Variant ID Type Subtype PubMed ID
esv2728772 CNV Deletion 23290073
esv34137 CNV Loss 18971310
esv2728774 CNV Deletion 23290073
nsv510894 CNV Complex 20534489
esv27476 CNV Loss 19812545
nsv822849 CNV Loss 20364138

Relevant External Links for WDR17 Gene

HapMap Linkage Disequilibrium report
WDR17

Disorders for WDR17 Gene

Relevant External Links for WDR17

Genetic Association Database (GAD)
WDR17
Human Genome Epidemiology (HuGE) Navigator
WDR17
genes like me logo Genes that share disorders with WDR17: view

No data available for UniProtKB/Swiss-Prot for WDR17 Gene

Publications for WDR17 Gene

  1. Cloning and characterization of WDR17, a novel WD repeat-containing gene on chromosome 4q34. (PMID: 12401215) Stohr H. … Weber B.H.F. (Biochim. Biophys. Acta 2002) 2 3 4
  2. Mapping of transcription start sites of human retina expressed genes. (PMID: 17286855) Roni V. … Wissinger B. (BMC Genomics 2007) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4

Products for WDR17 Gene

Sources for WDR17 Gene

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