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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR17 Gene

protein-coding   GIFtS: 45
GCID: GC04P176987

WD repeat domain 17
 Explore 2 diseases affiliated with
WDR17 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WDR17    

Aliases
for WDR17 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
WD Repeat Domain 171 2
WD Repeat-Containing Protein 172
EC 2.7.7.88
EC 6.1.18

External Ids:    HGNC: 166611   Entrez Gene: 1169662   Ensembl: ENSG000001506277   OMIM: 6090055   UniProtKB: Q8IZU23   

Export aliases for WDR17 gene to outside databases

Previous GC identifers: GC00U991124 GC04P177538 GC04P177683 GC04P177362 GC04P177224 GC04P172737


Summaries
for WDR17 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WDR17:
This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis, and is thought to be
a candidate gene for retinal disease. Alternatively spliced transcript variants have been found for this gene.
(provided by RefSeq, Nov 2009)




Genomic Views
for WDR17 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR17 gene promoter:
         HFH-3   COUP-TF1   Pax-5   COUP   HNF-4alpha2   HNF-4alpha1   FOXI1   HEN1   COUP-TF   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WDR17 promoter sequence
   Search SABiosciences Chromatin IP Primers for WDR17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34   Ensembl cytogenetic band:  4q34.2   HGNC cytogenetic band: 4q34

WDR17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR17 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P176987:  view genomic region     (about GC identifiers)

Start:
 176,986,985 bp from pter      End:
 177,103,979 bp from pter
Size:
 116,995 bases      Orientation:
 plus strand

Proteins
for WDR17 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WDR17_HUMAN, Q8IZU2 (See protein sequence)
Recommended Name: WD repeat-containing protein 17  
Size: 1322 amino acids; 147703 Da

Explore the universe of human proteins at neXtProt for WDR17: NX_Q8IZU2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IZU2

    • 2 DME Specific Peptides for WDR17 (Q8IZU2)
     TVLGESA  DDGTVRI 

    WDR17 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_733828.2  NP_851782.3  

    ENSEMBL proteins: 
     ENSP00000422763   ENSP00000280190   ENSP00000422200   ENSP00000427502   ENSP00000426847  
     ENSP00000426985   ENSP00000377258  

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    Protein Domains /
    Families
    for WDR17 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WDR17 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8IZU2

    ProtoNet protein and cluster: Q8IZU2

    UniProtKB/Swiss-Prot: WDR17_HUMAN, Q8IZU2
    Similarity: Contains 12 WD repeats


    Function
    for WDR17 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Enzyme Numbers (IUBMB): EC 6.1.12 EC 2.7.7.82

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Pathways & Interactions
    for WDR17 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR17

    1 Interacting protein for WDR17 (Q8IZU23) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ETS1P149213I2D: score=1 
    About this table

    Drugs & Compounds
    for WDR17 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for WDR17
    Search CenterWatch for drugs/clinical trials and news about WDR17 

    Transcripts
    for WDR17 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
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    About This Section
    REFSEQ mRNAs for WDR17 gene (2 alternative transcripts): 
    NM_170710.4  NM_181265.3  

    Unigene Clusters for WDR17:

    WD repeat domain 17
    Hs.532056  [show with all ESTs], Hs.693278
    Unigene Representative Sequences: NM_170710, BC118549
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508596(uc021xup.1) ENST00000509792 ENST00000280190 ENST00000507824
    ENST00000513261 ENST00000505894 ENST00000443118 ENST00000508773 ENST00000393643(uc003iuj.3 uc003ium.4 uc003iul.2 uc003iun.3)


    miRNA
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    hsa-miR-4316 hsa-miR-3671 hsa-miR-513b hsa-miR-1323 hsa-miR-3653 hsa-miR-590-3p hsa-miR-548o
    SwitchGear 3'UTR luciferase reporter plasmid: WDR17 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDR17 (see all 4)
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    Clone
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    Additional cDNA sequence: 

    BC118549.1 BC118627.1 

    6 DOTS entries:

    DT.100015107  DT.97768340  DT.121257163  DT.95305865  DT.97805887  DT.91667994 

    24/35 AceView cDNA sequences (see all 35):

    BX954313 AF492460 BM875452 BQ267492 BQ882167 BX508081 NM_170710 BM725970 
    AK130128 BM680980 NM_181265 AA668216 BM726935 AL712554 BM875703 BU741204 
    AL046290 AA371105 AK098748 BI713775 BQ640079 BX648508 BU570941 BQ270403 

    GeneLoc Exon Structure


    Expression
    for WDR17 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCATTATCTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    WDR17 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See WDR17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR17

    SOURCE GeneReport for Unigene clusters: Hs.532056 Hs.693278
        SABiosciences Custom PCR Arrays for WDR17
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR17

    Orthologs
    for WDR17 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for WDR17 gene from 3/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves WDR171 WD repeat domain 17 79.55(n)
    83.13(a)    		   422570  XM_003641165.1  XP_003641213.1 
    lizard
    (Anolis carolinensis)    		 Reptilia WDR176
    		 --
    		 83(a)
    		 1 ↔ 1
    		 5(117449613-117501276)
    zebrafish
    (Danio rerio)    		 Actinopterygii wdr171 WD repeat domain 17 71.66(n)
    81.9(a)    		   561804  NM_001201544.1  NP_001188473.1 


    ENSEMBL Gene Tree for WDR17 (if available)
    TreeFam Gene Tree for WDR17 (if available) 

    Paralogs
    for WDR17 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WDR17 gene
    PEX72  
    3 SIMAP similar genes for WDR17 using alignment to 8 protein entries:     WDR17_HUMAN (see all proteins):
    GNB5    PLRG1    PF20

    WDR17 for paralogs           About GeneDecksing



    Genomic Variants
    for WDR17 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for WDR17
         3 CNVs: 68842 47949 68843
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for WDR17 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WDR17 for disorders           About GeneDecksing

    OMIM gene information: 609005    OMIM disorders: --

    2 diseases for WDR17:    About MalaCards
    retinal disease    retinitis

    Human Genome Epidemiology (HuGE) Navigator: WDR17 (1 document)

    Export disorders for WDR17 gene to outside databases

    Publications
    for WDR17 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR17 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with WDR17)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of WDR17, a novel WD repeat-containing gene on chromosome 4q34. (PubMed id 12401215)1, 2, 3 Stohr H....Weber B.H.F. (2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    3. Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice. (PubMed id 19727342)1 Geisert E.E....Williams R.W. (2009)
    4. Mapping of transcription start sites of human retina expressed genes. (PubMed id 17286855)1 Roni V.... Wissinger B. (2007)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    6. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for WDR17 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing WDR17 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116966 HGNC: 16661 AceView: WDR17 Ensembl:ENSG00000150627 euGenes: HUgn116966
    ECgene: WDR17 H-InvDB: WDR17

    Other Databases showing WDR17 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WDR17 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR17 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for WDR17 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WDR17 gene:
    Search GeneIP for patents involving WDR17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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