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Aliases for WDR17 Gene

Aliases for WDR17 Gene

  • WD Repeat Domain 17 2 3 5
  • EC 2.7.7.8 58
  • EC 6.1.1 58

External Ids for WDR17 Gene

Previous GeneCards Identifiers for WDR17 Gene

  • GC00U991124
  • GC04P177538
  • GC04P177683
  • GC04P177362
  • GC04P177224
  • GC04P176987
  • GC04P172737

Summaries for WDR17 Gene

Entrez Gene Summary for WDR17 Gene

  • This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis, and is thought to be a candidate gene for retinal disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2009]

GeneCards Summary for WDR17 Gene

WDR17 (WD Repeat Domain 17) is a Protein Coding gene. An important paralog of this gene is PEX7.

Additional gene information for WDR17 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR17 Gene

Genomics for WDR17 Gene

Regulatory Elements for WDR17 Gene

Enhancers for WDR17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H176000 1.2 FANTOM5 ENCODE 15.6 -64.4 -64438 0 ZNF133 INSM2 ZNF76 FEZF1 ZNF2 ZNF366 ZSCAN5C ZNF398 ZFP69B ZNF341 GPM6A WDR17 ENSG00000248249
GH04H176065 0.9 ENCODE 20.5 +0.1 131 0 SIN3A BMI1 RFX5 GLIS2 ELK1 EGR2 USF2 ZEB2 ELF1 REST WDR17 GC04P176099
GH04H175946 0.5 Ensembl 10.5 -119.0 -119034 0 CTCF SMC3 ZNF143 RAD21 GPM6A WDR17 GC04M175911 ENSG00000248249
GH04H176348 0.5 ENCODE 10.3 +283.2 283171 0 SMARCE1 GATA3 DPF2 WDR17 ENSG00000248980 LOC100421630
GH04H176357 0.5 ENCODE 10 +291.9 291850 0 FOXA2 JUNB RUNX3 BATF WDR17 ENSG00000248980 LOC100421630
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR17 on UCSC Golden Path with GeneCards custom track

Promoters for WDR17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000176385 166 1200 SIN3A BMI1 RFX5 GLIS2 FOS EGR2 USF2 ZEB2 ELF1 REST

Genomic Location for WDR17 Gene

Chromosome:
4
Start:
176,065,834 bp from pter
End:
176,182,828 bp from pter
Size:
116,995 bases
Orientation:
Plus strand

Genomic View for WDR17 Gene

Genes around WDR17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR17 Gene

Proteins for WDR17 Gene

  • Protein details for WDR17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZU2-WDR17_HUMAN
    Recommended name:
    WD repeat-containing protein 17
    Protein Accession:
    Q8IZU2
    Secondary Accessions:
    • E7EQX0
    • Q0QD35

    Protein attributes for WDR17 Gene

    Size:
    1322 amino acids
    Molecular mass:
    147703 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BC146812; Type=Frameshift; Positions=268; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR17 Gene

Selected DME Specific Peptides for WDR17 Gene

Q8IZU2:
  • TVLGESA
  • DDGTVRI

Post-translational modifications for WDR17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for WDR17 Gene

Gene Families for WDR17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for WDR17 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR17: view

No data available for UniProtKB/Swiss-Prot for WDR17 Gene

Function for WDR17 Gene

Enzyme Numbers (IUBMB) for WDR17 Gene

Phenotypes for WDR17 Gene

genes like me logo Genes that share phenotypes with WDR17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WDR17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR17 Gene

Localization for WDR17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR17 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with WDR17: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDR17 Gene

Pathways & Interactions for WDR17 Gene

SuperPathways for WDR17 Gene

No Data Available

Interacting Proteins for WDR17 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000280190%0d%0a9606.ENSP00000353073%0d%0a9606.ENSP00000327077%0d%0a9606.ENSP00000316357%0d%0a9606.ENSP00000370395%0d%0a9606.ENSP00000295598%0d%0a
Selected Interacting proteins: Q8IZU2-WDR17_HUMAN ENSP00000280190 for WDR17 Gene via IID STRING

Gene Ontology (GO) - Biological Process for WDR17 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR17 Gene

Drugs & Compounds for WDR17 Gene

No Compound Related Data Available

Transcripts for WDR17 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WDR17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for WDR17 Gene

No ASD Table

Relevant External Links for WDR17 Gene

GeneLoc Exon Structure for
WDR17
ECgene alternative splicing isoforms for
WDR17

Expression for WDR17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR17 Gene

This gene is overexpressed in Monocytes (26.6), Fetal Brain (16.0), Frontal cortex (8.8), and Retina (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR17 Gene



Protein tissue co-expression partners for WDR17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR17 Gene:

WDR17

SOURCE GeneReport for Unigene cluster for WDR17 Gene:

Hs.532056

Evidence on tissue expression from TISSUES for WDR17 Gene

  • Eye(4.2)
genes like me logo Genes that share expression patterns with WDR17: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR17 Gene

Orthologs for WDR17 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR17 33 34
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia WDR17 33 34
  • 89.56 (n)
cow
(Bos Taurus)
Mammalia WDR17 33 34
  • 88.61 (n)
rat
(Rattus norvegicus)
Mammalia Wdr17 33
  • 86.45 (n)
mouse
(Mus musculus)
Mammalia Wdr17 33 16 34
  • 86.23 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR17 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR17 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR17 33 34
  • 79.69 (n)
lizard
(Anolis carolinensis)
Reptilia WDR17 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr17 33
  • 76.51 (n)
zebrafish
(Danio rerio)
Actinopterygii wdr17 33 34
  • 71.66 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEX7 34
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToOne
Species where no ortholog for WDR17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR17 Gene

ENSEMBL:
Gene Tree for WDR17 (if available)
TreeFam:
Gene Tree for WDR17 (if available)

Paralogs for WDR17 Gene

Paralogs for WDR17 Gene

(5) SIMAP similar genes for WDR17 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with WDR17: view

Variants for WDR17 Gene

Sequence variations from dbSNP and Humsavar for WDR17 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000026 -- 176,121,709(+) CCATA(A/G)GACAT intron-variant
rs1000004391 -- 176,132,987(+) ATCTG(G/T)CAGTG intron-variant
rs10000614 -- 176,118,580(+) TCAGC(A/G)AATTT intron-variant
rs1000077836 -- 176,070,669(+) CCACC(A/C)CTCTT intron-variant
rs1000083200 -- 176,065,129(+) TCTGG(C/T)TGAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WDR17 Gene

Variant ID Type Subtype PubMed ID
esv2728772 CNV deletion 23290073
esv2728774 CNV deletion 23290073
esv27476 CNV loss 19812545
esv3376172 CNV insertion 20981092
esv34137 CNV loss 18971310
esv3603271 CNV gain 21293372
esv3603274 CNV gain 21293372
nsv1017524 CNV gain 25217958
nsv1020249 CNV loss 25217958
nsv1024430 CNV loss 25217958
nsv510894 OTHER complex 20534489
nsv596262 CNV gain 21841781
nsv822849 CNV loss 20364138

Variation tolerance for WDR17 Gene

Residual Variation Intolerance Score: 53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.42; 97.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR17 Gene

Disorders for WDR17 Gene

Relevant External Links for WDR17

Genetic Association Database (GAD)
WDR17
Human Genome Epidemiology (HuGE) Navigator
WDR17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR17

No disorders were found for WDR17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR17 Gene

Publications for WDR17 Gene

  1. Cloning and characterization of WDR17, a novel WD repeat-containing gene on chromosome 4q34. (PMID: 12401215) Stöhr H … Weber BH (Biochimica et biophysica acta 2002) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Mapping of transcription start sites of human retina expressed genes. (PMID: 17286855) Roni V … Wissinger B (BMC genomics 2007) 3 4 60
  4. Concurrent Mutations in ATM and Genes Associated with Common γ Chain Signaling in Peripheral T Cell Lymphoma. (PMID: 26536348) Simpson HM … Banerjee A (PloS one 2015) 3 60
  5. Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice. (PMID: 19727342) Geisert EE … Williams RW (Molecular vision 2009) 3 60

Products for WDR17 Gene

Sources for WDR17 Gene

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