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WDR17 Gene

protein-coding   GIFtS: 38

GC04P177224
WD repeat domain 17
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for WDR17

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
FLJ26618 2
Descriptions
WD repeat domain 17 2
External Ids
HGNC: 166611
Entrez Gene: 1169662
UniProtKB: Q8IZU23
Ensembl: ENSG000001506277
Search outside databases for aliases for WDR17 gene

Previous GC identifers: GC00U991124 GC04P177538 GC04P177683 GC04P177362

Summaries
for WDR17

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for WDR17:
This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis.
Alternatively spliced transcript variants have been found for this gene, and they encode distinct
isoforms. [provided by RefSeq]

Genomic Location
for WDR17

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WDR17 gene  

Entrez Gene cytogenetic band: 4q34   Ensembl cytogenetic band:  4q34.2   HGNC cytogenetic band: 4q34

WDR17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P177224:     (about GC identifiers)

Start:
 177,224,126 bp from pter
End:
 177,340,960 bp from pter
Size:
 116,835 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000004.10  NT_022792.17  

Proteins
for WDR17

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: WDR17_HUMAN, Q8IZU2 (See protein sequence)
Recommended Name: WD repeat-containing protein 17  
Size: 1322 amino acids; 147703 Da

REFSEQ proteins (2 alternative transcripts): 
NP_733828.2  NP_851782.2  


ENSEMBL proteins: 
ENSP00000377258 ENSP00000296524 ENSP00000280190 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
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Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for WDR17: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for WDR17

Assays for WDR17: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for WDR17

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
5/6 InterPro domains/families (see all 6 ):
 IPR019782 WD40_repeat_2
 IPR019775 WD40_repeat_CS
 IPR019781 WD40_repeat_sg
 IPR001680 WD40_repeat
 IPR017986 WD40_repeat_region


   GeneDecks  WDR17 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q8IZU2

ProtoNet protein and cluster: Q8IZU2

UniProtKB/Swiss-Prot: WDR17_HUMAN, Q8IZU2
Similarity: Contains 12 WD repeats

Gene Function
for WDR17

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (WDR17)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_181265

              Applied Biosystems Silencer® siRNAs for WDR17

              Sigma-Aldrich siRNA for WDR17  
                     Sigma-Aldrich shRNA for WDR17  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_170710
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_170710
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_170710 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_170710

Pathways & Interactions
for WDR17

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for WDR17

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR17

Transcripts
for WDR17

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (WDR17)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_181265

              Sigma-Aldrich siRNA for WDR17  
                     Sigma-Aldrich shRNA for WDR17  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_170710  NM_181265  

REFSEQ mRNAs for WDR17 gene (2 alternative transcripts): 

NM_170710.3   NM_181265.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_170710  NM_181265  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_170710
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_170710
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_170710 

Additional cDNA sequence: 

AF492460.1 AK098748.1 AK130128.1 BC146812.1 BX648508.1 DQ426895.1 DQ426896.1 

6 DOTS entries:

DT.100015107  DT.121257163  DT.97768340  DT.95305865  DT.97805887  DT.91667994 

24/35 AceView cDNA sequences (see all 35 ):

BQ267492 AF492460 BQ882167 NM_181265 BM680980 BM875452 BX954313 AK130128 
NM_170710 BX508081 BM725970 BU570941 BM875703 BX648508 BQ270403 BI713775 
AK098748 AL046290 AL712554 BQ640079 BM726935 AA371105 BU741204 AA668216 

highest scoring ESTs for WDR17:

AA015883 AA371105 AL712554 AW962890 BI713506 BI713775 BM875452 BM875703 BQ267492 BQ269352 

Unigene Cluster for WDR17:

WD repeat domain 17
Hs.532056  [show with all ESTs]
Unigene Representative Sequence: NM_170710


GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:
ENST00000393643  ENST00000296524  ENST00000280190  

Expression
for WDR17

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR17 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for WDR17

1 / 2

2 probe-sets matching WDR17 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

1557132_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

1552430_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TCATTATCTA

SOURCE GeneReport for Unigene cluster: Hs.532056

Orthologs
for WDR17

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for WDR17 gene from 4 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 WDR171   -- WD repeat domain 17 89.69(n)
91.53(a)		 482934  XM_540049.2  XP_540049.2 
chimpanzee
(Pan troglodytes)		 WDR171   -- WD repeat domain 17 99.39(n)
99.31(a)		 471356  XM_526738.2  XP_526738.2 
mouse
(Mus musculus)		 Wdr171, 5 85
 WD repeat domain 171, 5 86.2(n)1
88.53(a)1		 2444841  NM_028220.21  NP_082496.21 
 AK0138895  AK0209955  (see all 9)
zebrafish
(Danio rerio)		 LOC5618041   -- similar to WD repeat domain 17 71.49(n)
81.51(a)		 561804  XM_685204.2  XP_690296.2 
About this table        Species with no ortholog for WDR17

ENSEMBL Gene Tree for WDR17

Paralogs
for WDR17

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for WDR17 gene
PEX72  

SNPs/Variants
for WDR17

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/731 NCBI SNPs in WDR17 are shown (see all 731 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 223)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 4 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs117368721,2
A,C,F,H177337638(+) AATCTA/GCTATC 2 A/T mis1 ese316Minor allele frequency- N:0.00EA NA EU WA 1414
rs76934531,2
C,F,H177319063(+) TGCTTG/CTGAAG 2 S/C mis1 ese317Minor allele frequency- C:0.22EA NA EU WA 1532
rs76999641,2
C,F,H177338054(+) AAATAT/GTGAAA 2 -- ut317Minor allele frequency- G:0.25NA EU EA WA 530
rs176259431,2
C,F,H177335279(+) GGAGAG/ACTTGC 2 T/A mis112Minor allele frequency- A:0.25NA EA EU WA 1054
rs46906611,2
C,F,H177310020(+) TACCTA/GCTAAA 2 A/T mis18Minor allele frequency- G:0.03EU EA WA 838
rs42762431,2
A,C177339967(+) TAAAAA/GATGAA 2 -- ut31 ese30--------
--
rs68106441,2
A,C177223027(+) GAATTA/TATTGA 2 -- ng51 tfbs30--------
--
rs45368761,2
A,C177339831(+) GTCATC/TCtttt 2 -- ut310--------
rs18252331,2
A,C177223978(+) ACGTGA/GGCCTC 2 -- ng51 tfbs30--------
--
rs100279961,2
A177223141(+) TAAGTA/TAATTT 2 -- ng51 tfbs30--------
About this table

HapMap Linkage Disequilibrium images for WDR17 (up to first 250kb)

Disorders & Mutations
for WDR17

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 609005

Medical News
for WDR17

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for WDR17

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

4 PubMed articles for WDR17 gene:

Search for WDR17

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing WDR17

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 116966 HGNC: 16661 AceView: WDR17 Ensembl:ENSG00000150627 euGenes: HUgn116966
ECgene: WDR17 H-InvDB: WDR17

Other Databases showing WDR17

(According to HUGE)
About This Section

   --

Specialized Databases showing WDR17

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for WDR17

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for WDR17

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for WDR17:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Lentivirus-delivered shRNAs for WDR17 Browse small molecules at Sigma-Aldrich
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