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Aliases for WDR17 Gene

Aliases for WDR17 Gene

  • WD Repeat Domain 17 2 3 5
  • EC 2.7.7.8 63
  • EC 6.1.1 63

External Ids for WDR17 Gene

Previous GeneCards Identifiers for WDR17 Gene

  • GC00U991124
  • GC04P177538
  • GC04P177683
  • GC04P177362
  • GC04P177224
  • GC04P176987
  • GC04P172737

Summaries for WDR17 Gene

Entrez Gene Summary for WDR17 Gene

  • This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis, and is thought to be a candidate gene for retinal disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2009]

GeneCards Summary for WDR17 Gene

WDR17 (WD Repeat Domain 17) is a Protein Coding gene. An important paralog of this gene is PEX7.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR17 Gene

Genomics for WDR17 Gene

Regulatory Elements for WDR17 Gene

Promoters for WDR17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR17 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR17 Gene

Chromosome:
4
Start:
176,065,834 bp from pter
End:
176,182,828 bp from pter
Size:
116,995 bases
Orientation:
Plus strand

Genomic View for WDR17 Gene

Genes around WDR17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR17 Gene

Proteins for WDR17 Gene

  • Protein details for WDR17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZU2-WDR17_HUMAN
    Recommended name:
    WD repeat-containing protein 17
    Protein Accession:
    Q8IZU2
    Secondary Accessions:
    • E7EQX0
    • Q0QD35

    Protein attributes for WDR17 Gene

    Size:
    1322 amino acids
    Molecular mass:
    147703 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BC146812; Type=Frameshift; Positions=268; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR17 Gene

Proteomics data for WDR17 Gene at MOPED

Selected DME Specific Peptides for WDR17 Gene

Post-translational modifications for WDR17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR17 Gene

Domains & Families for WDR17 Gene

Gene Families for WDR17 Gene

Suggested Antigen Peptide Sequences for WDR17 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IZU2

UniProtKB/Swiss-Prot:

WDR17_HUMAN :
  • Contains 12 WD repeats.
Similarity:
  • Contains 12 WD repeats.
genes like me logo Genes that share domains with WDR17: view

Function for WDR17 Gene

Enzyme Numbers (IUBMB) for WDR17 Gene

Phenotypes for WDR17 Gene

GenomeRNAi human phenotypes for WDR17:
genes like me logo Genes that share phenotypes with WDR17: view

Animal Model Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR17 Gene

Localization for WDR17 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR17 Gene COMPARTMENTS Subcellular localization image for WDR17 gene
Compartment Confidence
nucleus 3
cytosol 2
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR17 Gene

Pathways & Interactions for WDR17 Gene

SuperPathways for WDR17 Gene

No Data Available

Interacting Proteins for WDR17 Gene

Selected Interacting proteins: Q8IZU2-WDR17_HUMAN for WDR17 Gene via I2D

Symbol External ID(s) Details
ETS1

Gene Ontology (GO) - Biological Process for WDR17 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR17 Gene

Drugs & Compounds for WDR17 Gene

No Compound Related Data Available

Transcripts for WDR17 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for WDR17 Gene

No ASD Table

Relevant External Links for WDR17 Gene

GeneLoc Exon Structure for
WDR17
ECgene alternative splicing isoforms for
WDR17

Expression for WDR17 Gene

mRNA expression in normal human tissues for WDR17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR17 Gene

This gene is overexpressed in Monocytes (26.6), Fetal Brain (16.0), Frontal cortex (8.8), and Retina (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for WDR17 Gene



SOURCE GeneReport for Unigene cluster for WDR17 Gene Hs.532056

genes like me logo Genes that share expression patterns with WDR17: view

Protein tissue co-expression partners for WDR17 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR17 Gene

Orthologs for WDR17 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR17 35
  • 88.61 (n)
  • 91.4 (a)
WDR17 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR17 35
  • 89.56 (n)
  • 91.35 (a)
WDR17 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr17 35
  • 86.23 (n)
  • 88.53 (a)
Wdr17 16
Wdr17 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR17 35
  • 99.55 (n)
  • 99.47 (a)
WDR17 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr17 35
  • 86.45 (n)
  • 87.75 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR17 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR17 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR17 35
  • 79.69 (n)
  • 83.4 (a)
WDR17 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR17 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr17 35
  • 76.51 (n)
  • 85.51 (a)
zebrafish
(Danio rerio)
Actinopterygii wdr17 35
  • 71.66 (n)
  • 81.9 (a)
wdr17 36
  • 81 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEX7 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for WDR17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR17 Gene

ENSEMBL:
Gene Tree for WDR17 (if available)
TreeFam:
Gene Tree for WDR17 (if available)

Paralogs for WDR17 Gene

Paralogs for WDR17 Gene

(5) SIMAP similar genes for WDR17 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with WDR17: view

Variants for WDR17 Gene

Sequence variations from dbSNP and Humsavar for WDR17 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs4690661 - 176,151,875(+) TACCT(A/G)CTAAA reference, missense
rs7693453 - 176,160,918(+) TGCTT(C/G)TGAAG reference, missense
rs6810394 - 176,162,106(+) TGGCA(A/G)AATGG reference, missense
rs17625943 - 176,177,134(+) GGAGA(A/G)CTTGC reference, missense
rs11736872 - 176,179,493(+) AATCT(A/G)CTATC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for WDR17 Gene

Variant ID Type Subtype PubMed ID
esv2728772 CNV Deletion 23290073
esv34137 CNV Loss 18971310
esv2728774 CNV Deletion 23290073
nsv510894 CNV Complex 20534489
esv27476 CNV Loss 19812545
nsv822849 CNV Loss 20364138

Variation tolerance for WDR17 Gene

Residual Variation Intolerance Score: 53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.42; 97.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR17 Gene

HapMap Linkage Disequilibrium report
WDR17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR17 Gene

Disorders for WDR17 Gene

Relevant External Links for WDR17

Genetic Association Database (GAD)
WDR17
Human Genome Epidemiology (HuGE) Navigator
WDR17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR17

No disorders were found for WDR17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR17 Gene

Publications for WDR17 Gene

  1. Cloning and characterization of WDR17, a novel WD repeat-containing gene on chromosome 4q34. (PMID: 12401215) Stohr H. … Weber B.H.F. (Biochim. Biophys. Acta 2002) 2 3 4 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice. (PMID: 19727342) Geisert E.E. … Williams R.W. (Mol. Vis. 2009) 3
  4. Mapping of transcription start sites of human retina expressed genes. (PMID: 17286855) Roni V. … Wissinger B. (BMC Genomics 2007) 3
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3

Products for WDR17 Gene

Sources for WDR17 Gene

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