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WDR16 Gene

protein-coding   GIFtS: 48
GCID: GC17P009479

WD Repeat Domain 16

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 161 2
WDRPUH2 3 5
WD40-Repeat Protein Upregulated In HCC1 2
WD40-Repeat Protein Up-Regulated In HCC2 3
WD Repeat-Containing Protein 162

External Ids:    HGNC: 160531   Entrez Gene: 1468452   Ensembl: ENSG000001665967   OMIM: 6098045   UniProtKB: Q8N1V23   

Export aliases for WDR16 gene to outside databases

Previous GC identifers: GC00U991035 GC17P009422


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WDR16 Gene:
WD repeat-containing proteins, such as WDR16, play crucial roles in a wide range of physiologic functions,
including signal transduction, RNA processing, remodeling the cytoskeleton, regulation of vesicular traffic, and
cell division (Silva et al., 2005 (PubMed 15967112)).(supplied by OMIM, Mar 2008)

GeneCards Summary for WDR16 Gene:
WDR16 (WD repeat domain 16) is a protein-coding gene. Diseases associated with WDR16 include hepatocellular carcinoma, and malaria. An important paralog of this gene is WDR90.

UniProtKB/Swiss-Prot: WDR16_HUMAN, Q8N1V2
Function: May play an essential role in the growth or survival of hepatocellular carcinoma (HCC)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR16 gene promoter:
         HOXA3   MEF-2   YY1   Gfi-1   MEF-2A   POU2F1   POU2F1a   FOXJ2 (long isoform)   aMEF-2   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR16 promoter sequence
   Search Chromatin IP Primers for WDR16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

WDR16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR16 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P009479:  view genomic region     (about GC identifiers)

Start:
9,479,944 bp from pter      End:
9,546,776 bp from pter
Size:
66,833 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: WDR16_HUMAN, Q8N1V2 (See protein sequence)
Recommended Name: WD repeat-containing protein 16  
Size: 620 amino acids; 68298 Da
Miscellaneous: May be a good candidate as a diagnostic marker for HCC as well as a potential molecular target for
development of novel therapeutic drugs
Sequence caution: Sequence=BAB85083.1; Type=Frameshift; Positions=183;
Secondary accessions: B2RDU7 Q5DX23 Q8TC73 Q8TCI3
Alternative splicing: 3 isoforms:  Q8N1V2-1   Q8N1V2-2   Q8N1V2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR16: NX_Q8N1V2

Explore proteomics data for WDR16 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WDR16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001074025.1  NP_659491.4  

    ENSEMBL proteins: 
     ENSP00000379521   ENSP00000339449   ENSP00000459671   ENSP00000459347   ENSP00000458398  
     ENSP00000458343   ENSP00000476293   ENSP00000468193   ENSP00000299764  

    WDR16 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for WDR16

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    Cloud-Clone Corp. CLIAs for WDR16


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR011047 Quinonprotein_ADH-like_supfam
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8N1V2

    ProtoNet protein and cluster: Q8N1V2

    1 Blocks protein domain: IPB000408 Regulator of chromosome condensation

    UniProtKB/Swiss-Prot: WDR16_HUMAN, Q8N1V2
    Similarity: Contains 11 WD repeats


    WDR16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR16_HUMAN, Q8N1V2
    Function: May play an essential role in the growth or survival of hepatocellular carcinoma (HCC)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15967112
         
    WDR16 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WDR16:
     Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDR16
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WDR16
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WDR16

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate WDR16:
    hsa-miR-539
    SwitchGear 3'UTR luciferase reporter plasmidWDR16 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WDR16
    Predesigned siRNA for gene silencing in human, mouse, rat WDR16

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR16


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WDR16_HUMAN, Q8N1V2: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    WDR16 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR16
    Interactions:

        Search GeneGlobe Interaction Network for WDR16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for WDR16 (Q8N1V23 ENSP000003394494) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR16



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WDR16 gene (2 alternative transcripts): 
    NM_001080556.1  NM_145054.4  

    Unigene Cluster for WDR16:

    WD repeat domain 16
    Hs.232270  [show with all ESTs]
    Unigene Representative Sequence: AK094847
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396219 ENST00000352665(uc002gly.3 uc002glz.3) ENST00000575247
    ENST00000574937 ENST00000572333 ENST00000576630(uc010coc.3) ENST00000576499
    ENST00000576320 ENST00000576714 ENST00000574097 ENST00000299764
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat WDR16 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate WDR16:
    hsa-miR-539
    SwitchGear 3'UTR luciferase reporter plasmidWDR16 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WDR16
    Predesigned siRNA for gene silencing in human, mouse, rat WDR16
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    OriGene ORF clones in mouse, rat for WDR16
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat WDR16

    Additional mRNA sequence: 

    AB065281.1 AK074435.1 AK094847.1 AK315679.1 BC025392.2 

    6 DOTS entries:

    DT.100018101  DT.97814285  DT.100010615  DT.407611  DT.75100830  DT.91642768 

    Selected AceView cDNA sequences (see all 65):

    BM702192 AW665127 BQ186259 BU683791 BU684845 AI460076 BE348232 AJ583817 
    CA406696 AA677708 AI032899 BC039653 BU608435 BX095772 BM664887 NM_145054 
    BC025392 AK055188 AI032712 AW105540 BU753109 AW665059 H01440 BX648526 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for WDR16    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                                                                                                      
    SP2:              -                                                                                       
    SP3:              -     -                                                                                 


    ECgene alternative splicing isoforms for WDR16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATATCACAC
    WDR16 Expression
    About this image

    WDR16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.232270

    UniProtKB/Swiss-Prot: WDR16_HUMAN, Q8N1V2
    Tissue specificity: Highly expressed in testis. Up-regulated in hepatocellular carcinoma (HCC)

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WDR16 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr161 , 5 WD repeat domain 161, 5 86.18(n)1
    90.81(a)1
      11 (41.16 cM)5
    718601  NM_027963.21  NP_082239.21 
     679248065 
    chicken
    (Gallus gallus)
    Aves WDR161 WD repeat domain 16 71.96(n)
    71.19(a)
      417322  XM_415591.3  XP_415591.2 
    lizard
    (Anolis carolinensis)
    Reptilia WDR166
    WD repeat domain 16
    72(a)
    1 ↔ 1
    2(105682948-105724480)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF290247.12   -- 75.11(n)    CF290247.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj15f102 Transcribed sequence with weak similarity to protein more 78.37(n)    BQ481255.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG100641 CG10064 50.11(n)
    38.83(a)
      38761  NM_139808.2  NP_648065.1 


    ENSEMBL Gene Tree for WDR16 (if available)
    TreeFam Gene Tree for WDR16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR16 gene
    WDR902  

    WDR16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR16 (see all 1551)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2020016321,2
    C--9481411(+) TCAAA-/AAAT  
            
    AAATA
    2 -- int10--------
    rs1876134411,2
    --9481420(+) TAAATA/GAATAA 2 -- int10--------
    rs768831051,2
    C,F--9481431(+) ATAAAC/TAAACA 2 -- int13Minor allele frequency- T:0.14WA CSA 122
    rs1155431101,2
    C--9481527(+) GTAATA/CTATCA 2 -- int10--------
    rs1926306591,2
    --9481618(+) CATGAC/TGGCAC 2 -- int10--------
    rs1856245851,2
    --9481648(+) TAAACC/TGGCCA 2 -- int10--------
    rs1905819591,2
    --9481661(+) GGTAGA/TCCGTG 2 -- int10--------
    rs800186351,2
    C,F--9481663(+) TAGTCC/TGTGGT 2 -- int11Minor allele frequency- T:0.09WA 118
    rs80649151,2
    C,F,H--9481706(+) aatcaG/Ctctgt 2 -- int118Minor allele frequency- C:0.04NS EA NA WA CSA 1227
    rs1816354971,2
    --9481739(+) TGGCGA/GGTTGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for WDR16 (9479944 - 9546776 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WDR16:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1975CNV Insertion18451855
    nsv833357CNV Loss17160897
    nsv7289OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR16
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609804    OMIM disorders: --

    2 diseases for WDR16:    About MalaCards
    hepatocellular carcinoma    malaria


    WDR16 for disorders           About GeneDecksing


    Export disorders for WDR16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR16 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with WDR16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. WDRPUH, a novel WD-repeat-containing protein, is highly expressed in human hepatocellular carcinoma and involved in cell proliferation. (PubMed id 15967112)1, 2, 3 Silva F.P.... Furukawa Y. (Neoplasia 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 146845 HGNC: 16053 AceView: LOC146845 Ensembl:ENSG00000166596 euGenes: HUgn146845
    ECgene: WDR16 H-InvDB: WDR16

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WDR16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDR16 gene:
    Search GeneIP for patents involving WDR16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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