WDR13 Gene
protein-coding GIFtS: 46
GCID: GC0XP048448
|
|
WD repeat domain 13
| |
Aliases
for WDR13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| WD Repeat Domain 131 2 | | MG212 | | WD Repeat-Containing Protein 132 |
| External Ids: | HGNC: 143521 | Entrez Gene: 647432 | Ensembl: ENSG000001019407 | OMIM: 3005125 | UniProtKB: Q9H1Z43 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n408350 | |
Export aliases for WDR13 gene to outside databasesPrevious GC identifers: GC0XP047258 GC0XP046716 GC0XP047501 GC0XP048203 GC0XP048332 GC0XP046119
Summaries
for WDR13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WDR13:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric ormultiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycleprogression, signal transduction, apoptosis, and gene regulation. This gene is widely expressed in various tissues.Multiple alternatively spliced transcript variants have been described for this gene. (provided by RefSeq, Oct 2009)
|
Genomic Views
for WDR13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR13 gene promoter:
Nkx5-1 AREB6 RORalpha1 ARP-1 FOXO1a ZIC2/Zic2 Zic3 Ik-1 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR13
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR13 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23WDR13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP048448: view genomic region
(about GC identifiers)
Start:
|
48,448,430 bp from pter |
End:
|
48,463,582 bp from pter |
Size:
|
15,153 bases |
Orientation:
|
plus strand |
|
Proteins
for WDR13 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR13_HUMAN, Q9H1Z4 (See
protein sequence)Recommended Name: WD repeat-containing protein 13 Size: 485 amino acids; 53696 Da
Subcellular location: Nucleus
Sequence caution: Sequence=BAA91261.1; Type=Erroneous initiation;
Secondary accessions: Q06DX1 Q9BUL7 Q9NWW4Explore the universe of human proteins at neXtProt for WDR13: NX_Q9H1Z4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H1Z4
WDR13 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001159898.1 NP_060353.2
ENSEMBL proteins: ENSP00000365919 ENSP00000218056
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
WDR13 for ontologies About GeneDecksing
WDR13 Antibody Products:
Assay Products for WDR13: |
Protein
Domains /
Families
for WDR13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR13 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H1Z4ProtoNet protein and cluster: Q9H1Z4 UniProtKB/Swiss-Prot: WDR13_HUMAN, Q9H1Z4Similarity: Contains 5 WD repeats |
Function
for WDR13 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR13 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR13 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR13 |
|
Pathways & Interactions
for WDR13 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR13
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for WDR13 (Q9H1Z43 ENSP000002180564) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for WDR13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR13
Search CenterWatch for drugs/clinical trials and news about WDR13
|
Transcripts
for WDR13 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR13 gene (2 alternative transcripts): NM_001166426.1 NM_017883.4 Unigene Cluster for WDR13: WD repeat domain 13 Hs.521973 [show with all ESTs]Unigene Representative Sequence: L0823714 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000470124 ENST00000376729(uc011mme.2) ENST00000218056(uc004dkk.2 uc004dkj.2)
ENST00000497756 ENST00000498631 ENST00000471334 ENST00000486125 ENST00000472440
ENST00000492715 ENST00000479279(uc004dkl.4) ENST00000466962 ENST00000495575
ENST00000482760 ENST00000492873
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR13 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR13 (see all 2)
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Additional cDNA sequence: AF158978.1 AF329819.4 AK000570.1 AK225542.1 AK301186.1 AK314739.1 BC002507.2 BC067094.1 BC080579.1 BX649101.1 DQ907252.1 DQ907253.1 DQ907254.1 DQ907255.1 L08237.1 NR_029427.1 24/29 DOTS entries (see all 29): DT.448318 DT.95369648 DT.121290946 DT.95369636 DT.100030267 DT.100846235 DT.100688082 DT.95369645 DT.95369633 DT.100665888 DT.100831352 DT.100846228 DT.100846237 DT.95369647 DT.100846226 DT.100846259 DT.121290947 DT.95369640 DT.97855125 DT.100771447 DT.100846227 DT.100846244 DT.100846248 DT.121290913 24/458 AceView cDNA sequences (see all 458): CR619297 CD364750 CR623686 BG058665 BM772573 BE796085 AI654318 CR623068 F09364 CN479530 BM746507 BM742221 CR603392 AW161551 AA349220 BE269295 AI200564 BC002507 BM463723 CR621485 BM764597 AI758617 AW157124 BE888289
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for WDR13 (see all 13) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | |
| SP4: | | | | | | | | | | | | | - | | - | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | - | | | | | | - | | |
| SP5: | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 12b | ^ | 13a | · | 13b | · | 13c | · | 13d |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | | |
| SP3: | | | | | | | | | | | |
| SP4: | | | | | | | | | | | |
| SP5: | | | | | | | | | | |
ECgene alternative splicing isoforms for WDR13
|
Expression
for WDR13 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See WDR13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR13
SOURCE GeneReport for Unigene cluster: Hs.521973
UniProtKB/Swiss-Prot: WDR13_HUMAN, Q9H1Z4Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for WDR13
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR13
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR13 |
Orthologs
for WDR13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WDR13 gene from 8/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Wdr131 , 5 |
WD repeat domain 131, 5 |
90.38(n)1
99.18(a)1 |
|
X (3.67 cM)5
734471 NM_026137.41 NP_080413.21
81233015 |
chicken
(Gallus gallus) |
Aves |
WDR131 |
WD repeat domain 13 |
71.82(n)
74.03(a) |
|
776425 XM_001235947.2 XP_001235948.2 |
lizard
(Anolis carolinensis) |
Reptilia |
WDR136 |
-- |
89(a) |
1 ↔ 1 |
2(69521922-69527654) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.153542 |
Xenopus laevis transcribed sequence with moderate similarity to protein refNP_060353.2 (H.sapiens) WD repeat domain 13 protein [Homo sapiens] less |
77.32(n) |
|
CB591223.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufa04f022 |
wufa04f02 |
76.36(n) |
|
334827 CK361970.1 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
43(a) |
1 ↔ 1 |
GroupUn.71(25797-28448) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT2G164056 |
transducin/WD-40 repeat-containing protein |
30(a) |
1 ↔ 1 |
2(7105752-7108972) |
rice
(Oryza sativa) |
Liliopsida |
-- |
WD domain, G-beta repeat domain containing protein... |
30(a) |
1 ↔ 1 |
1(32837479-32841429) |
ENSEMBL Gene Tree for WDR13 (if available)
TreeFam Gene Tree for WDR13 (if available) |
Paralogs
for WDR13 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for WDR13 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR13 (48448430 - 48463582 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for WDR13
1 CNV: 7789
Human Gene Mutation Database (HGMD): WDR13
Locus Specific Mutation Databases (LSDB): WDR13
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR13 |
|
Disorders
/ Diseases
for WDR13 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDR13 for disorders About GeneDecksing
OMIM gene information: 300512
OMIM disorders: --
1  disease for WDR13: About MalaCardswilliams-beuren syndrome
Export disorders for WDR13 gene to outside databases
|
Publications
for WDR13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR13 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with WDR13) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A highly conserved human gene encoding a novel member of WD-repeat family of proteins (WDR13). (PubMed id 12659815)1, 2 Singh B.N.... Singh L. (2003)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
|
External Searches for WDR13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR13 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR13 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR13 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR13 gene:
Search GeneIP for patents involving WDR13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR13 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
 |
 |
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| |
 |  |  |  | |
| | | | Search Tocris compounds for WDR13 |
| |  |  |  |  | | | | |
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 |
 |
 | | | WDR13 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR13 |
|  |  |  | | | | Search ThermoFisher Antibodies for WDR13 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR13 |
|
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Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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