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WDR13 Gene

protein-coding   GIFtS: 47

GC0XP048332
WD repeat domain 13
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZp779C2057 2
FLJ20563 2
MG21 2
OTTHUMP00000025798 2
OTTHUMP00000025799 2
Descriptions
WD repeat domain 13 2
WD repeat domain 13 protein 2
located at OATL1 2
External Ids
HGNC: 143521
Entrez Gene: 647432
UniProtKB: Q9H1Z43
Ensembl: ENSG000001019407
Search outside databases for aliases for WDR13 gene

Previous GC identifers: GC0XP047258 GC0XP046716 GC0XP047501 GC0XP048203

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for WDR13:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved
regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which
may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are
involved in a variety of cellular processes, including cell cycle progression, signal
transduction, apoptosis, and gene regulation. This gene is widely expressed in various tissues,
and located in chromosome X. The function of this gene has not been determined. [provided by
RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WDR13 gene  

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

WDR13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP048332:     (about GC identifiers)

Start:
48,332,467 bp from pter
End:
48,348,518 bp from pter
Size:
16,052 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000023.9  NT_079573.3  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WDR13_HUMAN, Q9H1Z4 (See protein sequence)
Recommended Name: WD repeat-containing protein 13  
Size: 485 amino acids; 53715 Da
Subcellular location: Nucleus
Secondary accessions: Q06DX1 Q9BUL7 Q9NWW4

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_060353.2  

    ENSEMBL proteins: 
    ENSP00000218056 ENSP00000343203 ENSP00000365919 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (WDR13)
    Human Recombinant Proteins from Abnova (WDR13)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005730NOT nucleolus IDA18029348
    GO:0005737 cytoplasm IDA18029348
    About this table

    Antibodies for WDR13: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for WDR13
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (WDR13), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (WDR13)
    Novus Biologicals Antibodies for WDR13

    Assays for WDR13: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR019782 WD40_repeat_2
     IPR019775 WD40_repeat_CS
     IPR019781 WD40_repeat_sg
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_region


       GeneDecks  WDR13 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9H1Z4

    ProtoNet protein and cluster: Q9H1Z4

    UniProtKB/Swiss-Prot: WDR13_HUMAN, Q9H1Z4
    Similarity: Contains 5 WD repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WDR13)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017883

                  Applied Biosystems Silencer® siRNAs for WDR13

                  Sigma-Aldrich siRNA for WDR13  
                         Sigma-Aldrich shRNA for WDR13  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for WDR13
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_017883
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_017883
                                     untagged cDNA clone in CMV expression vector: NM_017883 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_017883

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for WDR13

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WDR13)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017883

                  Sigma-Aldrich siRNA for WDR13  
                         Sigma-Aldrich shRNA for WDR13  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_017883  

    REFSEQ mRNAs for WDR13 gene: 

    NM_017883.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_017883  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_017883
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_017883
                                     untagged cDNA clone in CMV expression vector: NM_017883 

    Additional cDNA sequence: 

    AF329819.4 AK000570.1 AK225542.1 AK301186.1 AK314739.1 BC002507.2 BC067094.1 BC080579.1 
    BX649101.1 CR591373.1 CR593655.1 CR594799.1 CR595978.1 CR597236.1 CR598742.1 CR598919.1 
    CR601096.1 CR601751.1 CR602069.1 CR602306.1 CR602965.1 CR603392.1 CR604375.1 CR613575.1 
    CR616329.1 CR619297.1 CR620990.1 CR621485.1 CR623068.1 CR623686.1 CR624965.1 DQ907252.1 
    DQ907253.1 DQ907254.1 DQ907255.1 L08237.1 

    24/30 DOTS entries (see all 30 ):

    DT.448318  DT.95369648  DT.121290946  DT.95369636  DT.100030267  DT.100846235  DT.100688082  DT.95369645 
    DT.100831352  DT.95369633  DT.121290947  DT.100665888  DT.97767429  DT.97855125  DT.100846228  DT.100846237 
    DT.100846248  DT.92018266  DT.95369647  DT.100846226  DT.100846259  DT.40296783  DT.95369640  DT.100771447 

    24/458 AceView cDNA sequences (see all 458 ):

    CR598742 AI878966 BG058665 BX113632 AI654318 CR623686 CA488714 BM753291 
    BM746507 CR597236 BU147000 CR620990 BM742490 BE888289 CR603392 BM821820 
    BE796085 BM463723 BQ669278 BQ951128 BU739680 F09364 BM055139 BU736394 

    highest scoring ESTs for WDR13:

    AI660689 AA074547 AA079858 AA161211 AA161235 AA349220 AA402272 AA477143 AA477390 AA488064 

    Unigene Cluster for WDR13:

    WD repeat domain 13
    Hs.521973  [show with all ESTs]
    Unigene Representative Sequence: L08237


    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for WDR13 (see all 13 )

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a ·
    SP1:                                                              -                                                                 -     -                 -   
    SP2:                                                              -     -                                                           -     -                 -   
    SP3:                                                                                                                                -     -                 -   
    SP4:                                      -     -           -     -     -     -     -     -     -     -     -                       -     -                 -   
    SP5:                                      -     -                 -                                                                                             

    ExUns: 12b ^ 13a · 13b · 13c · 13d
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              

    About this scheme

    ECgene alternative splicing isoforms for WDR13

    3 Ensembl transcripts including schematic representations:
    ENST00000218056  ENST00000344046  ENST00000376729  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    WDR13 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for WDR13

    1 / 2 / 3

    4 probe-sets matching WDR13 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    727_at2, 3 U95-A 1 1.00 1.00 0.94 0.81 HG1804-HT1829 0.20 1.00 0.72 1

    56527_at2, 3 U95-B 1 1.00 1.00 0.96 1.19 AI660689 1.00 1.00 1.00 1

    222138_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF158978 0.60 1.00 0.82 1

    222138_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  WDR13 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.521973

    UniProtKB/Swiss-Prot: WDR13_HUMAN, Q9H1Z4
    Tissue specificity: Widely expressed

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for WDR13 gene from 5/12 species (see all 12 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    WDR131   -- WD repeat domain 13 92.92(n)
    99.59(a)
    480904  XM_858016.1  XP_863109.1 
    chimpanzee
    (Pan troglodytes)
    WDR131   -- WD repeat domain 13 99.86(n)
    100(a)
    449584  NM_001009006.1  NP_001009006.1 
    cow
    (Bos taurus)
    WDR131   -- WD repeat domain 13 89.77(n)
    97.21(a)
    523881  NM_001075850.1  NP_001069318.1 
    rat
    (Rattus norvegicus)
    Wdr131   -- WD repeat domain 13 90.58(n)
    99.18(a)
    317370  XM_228783.4  XP_228783.4 
    mouse
    (Mus musculus)
    Wdr131, 5 X (2.05 cM)5
    WD repeat domain 131, 5 90.31(n)1
    98.97(a)1
    734471  NM_026137.31  NP_080413.11 
     AF2201465  AF3532435  (see all 22)
    About this table        Species with no ortholog for WDR13

    ENSEMBL Gene Tree for WDR13
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/56 NCBI SNPs in WDR13 are shown (see all 56 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 47)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs2358241,2
    C,F,H,O48341167(+) CCGGGT/GGGGAG 1 -- ut5112Minor allele frequency- G:0.23EA NA EU WA 883
    rs2358421,2
    C,H48345258(-) TGCCAC/TGGTCA 1 R/H mis14Minor allele frequency- T:0.00EU EA WA 418
    rs59066831,2
    H48348841(+) ctgcaG/Aaagtt 1 -- ng314Minor allele frequency- A:0.00EU EA WA 396
    rs41311271,2
    C48338850(+) aaaaCA/GTAAGG 1 -- ng510--------
    rs2358431,2
    C,F,H,O48344906(-) GCCTAT/CGGGAC 1 -- int17Minor allele frequency- C:0.25EU EA WA NA 523
    rs2358451,2
    A,C,F,H48344695(-) CACTAA/CACCCC 1 -- int17Minor allele frequency- C:0.25EU EA WA NA 521
    rs2358401,2
    A,C,F,H48347895(-) TGTGAG/CTTCTC 1 -- int111Minor allele frequency- C:0.39EA NA EU WA 794
    rs2358461,2
    A,C,F,H48344454(-) GGCCAT/ACCCAG 1 -- int14Minor allele frequency- A:0.25EU EA WA 418
    rs22939491,2
    C,F,H48345330(+) TGCTCG/ACCCTC 1 -- int13Minor allele frequency- A:0.06EA WA 298
    rs2358441,2
    A,C,F48344805(-) TTTCCC/TCTGCT 1 -- int14Minor allele frequency- T:0.48MN NA 322
    About this table

    HapMap Linkage Disequilibrium images for WDR13 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 300512

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    9 PubMed articles for WDR13 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 64743 HGNC: 14352 AceView: WDR13 Ensembl:ENSG00000101940 euGenes: HUgn64743
    ECgene: WDR13 H-InvDB: WDR13
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for WDR13:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for WDR13 Antibodies for WDR13
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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