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WDR12 Gene

protein-coding   GIFtS: 55
GCID: GC02M203709

WD Repeat Domain 12

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 121 2
WD Repeat-Containing Protein 122 3
YTM12
Ribosome Biogenesis Protein WDR122

External Ids:    HGNC: 140981   Entrez Gene: 557592   Ensembl: ENSG000001384427   UniProtKB: Q9GZL73   

Export aliases for WDR12 gene to outside databases

Previous GC identifers: GC02M201962 GC02M202469 GC02M203947 GC02M203570 GC02M203453 GC02M195592


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WDR12 Gene:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of
approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation
of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular
processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is
highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene
is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.(provided by
RefSeq, Dec 2008)

GeneCards Summary for WDR12 Gene:
WDR12 (WD repeat domain 12) is a protein-coding gene. An important paralog of this gene is WDR37.

UniProtKB/Swiss-Prot: WDR12_HUMAN, Q9GZL7
Function: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and
formation of the 60S ribosome

Gene Wiki entry for WDR12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR12 gene promoter:
         Egr-1   FOXO3   AP-4   FOXO3b   POU2F1   POU2F1a   FOXO3a   c-Myb   MRF-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR12 promoter sequence
   Search Chromatin IP Primers for WDR12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.2   Ensembl cytogenetic band:  2q33.2   HGNC cytogenetic band: 2q33.1

WDR12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR12 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M203709:  view genomic region     (about GC identifiers)

Start:
203,739,505 bp from pter      End:
203,879,521 bp from pter
Size:
140,017 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WDR12_HUMAN, Q9GZL7 (See protein sequence)
Recommended Name: Ribosome biogenesis protein WDR12  
Size: 423 amino acids; 47708 Da
Subunit: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts
directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome
Secondary accessions: B3KPA9 Q96HU0 Q9NV80 Q9NYI8

Explore the universe of human proteins at neXtProt for WDR12: NX_Q9GZL7

Explore proteomics data for WDR12 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys203
  • Modification sites at PhosphoSitePlus

  • See WDR12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060726.3  
    ENSEMBL proteins: 
     ENSP00000261015  

    WDR12 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 7):
     IPR012972 NLE
     IPR019775 WD40_repeat_CS
     IPR028599 WDR12/Ytm1
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep

    Graphical View of Domain Structure for InterPro Entry Q9GZL7

    ProtoNet protein and cluster: Q9GZL7

    1 Blocks protein domain: IPB012972 NLE

    UniProtKB/Swiss-Prot: WDR12_HUMAN, Q9GZL7
    Similarity: Belongs to the WD repeat WDR12/YTM1 family
    Similarity: Contains 7 WD repeats


    Find genes that share domains with WDR12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR12_HUMAN, Q9GZL7
    Function: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and
    formation of the 60S ribosome
    Induction: By MYC

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16043514
    GO:0043021ribonucleoprotein complex binding IEA--
         
    Find genes that share ontologies with WDR12           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for WDR12:
     Increased S DNA content  S arrest 

         1 MGI phenotypic allele for Wdr12 (no phenotypes)

    Find genes that share phenotypes with WDR12           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDR12
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WDR12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WDR12
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    hsa-mir-193b-3p (MIRT041501), hsa-mir-30a-5p (MIRT028635)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WDR12_HUMAN, Q9GZL7: Nucleus, nucleolus. Nucleus, nucleoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm IDA16043514
    GO:0005730nucleolus IDA16043514
    GO:0030687preribosome, large subunit precursor IDA17353269
    GO:0070545PeBoW complex IDA16043514

    Find genes that share ontologies with WDR12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WDR12 About    
    See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway (KEGG)
    Delta-Notch Signaling Pathway0.33


    1 BioSystems Pathway for WDR12
        Delta-Notch Signaling Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR12
    Interactions:

        GeneGlobe Interaction Network for WDR12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WDR12 (Q9GZL71, 3 ENSP000002610154) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BOP1Q141371, 3, ENSP000003041514EBI-2490660,EBI-1050828 I2D: score=5 STRING: ENSP00000304151
    CSNK2BP678703I2D: score=5 
    ENSG00000206406P678703I2D: score=5 
    ENSG00000224398P678703I2D: score=5 
    ENSG00000224774P678703I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000463maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP16043514
    GO:0000466maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP16043514
    GO:0007219Notch signaling pathway IEA--
    GO:0008283cell proliferation IMP16043514
    GO:0042273ribosomal large subunit biogenesis IC16043514

    Find genes that share ontologies with WDR12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR12



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDR12 gene: 
    NM_018256.3  

    Unigene Cluster for WDR12:

    WD repeat domain 12
    Hs.73291  [show with all ESTs]
    Unigene Representative Sequence: NM_018256
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261015(uc002uzl.3) ENST00000467777 ENST00000464820 ENST00000463824
    ENST00000477727 ENST00000475611 ENST00000478869 ENST00000477723
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidWDR12 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: WDR12 (NM_018256)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDR12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR12
    Primer
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    OriGene qPCR primer pairs and template standards for WDR12
    OriGene qSTAR qPCR primer pairs in human, mouse for WDR12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR12
      QuantiTect SYBR Green Assays in human, mouse, rat WDR12
      QuantiFast Probe-based Assays in human, mouse, rat WDR12

    Additional mRNA sequence: 

    AF242546.1 AK001743.1 AK022781.1 AK022782.1 AK056092.1 AK299489.1 BC008082.2 EF011617.1 

    8 DOTS entries:

    DT.311726  DT.100785265  DT.100646866  DT.121032090  DT.92434391  DT.95154121  DT.121032085  DT.97780315 

    Selected AceView cDNA sequences (see all 164):

    BX281691 BP871327 BG388924 BU190274 CR613990 BF170904 AI246255 CB132835 
    BM827535 BU631214 CR622430 CA420134 BP366830 AA587202 BI858072 AI382380 
    AI680131 AI696102 AI951347 BC008082 AA807928 AI278377 AA911053 CB131976 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for WDR12    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                            -                                                   
    SP2:                                -                                                               
    SP3:                                                                                                
    SP4:                                                                                                


    ECgene alternative splicing isoforms for WDR12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTACATA
    WDR12 Expression
    About this image

    WDR12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73291
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDR12 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr121 , 5 WD repeat domain 121, 5 89.6(n)1
    93.85(a)1
      1 (30.45 cM)5
    577501  NM_021312.51  NP_067287.11 
     600768685 
    chicken
    (Gallus gallus)
    Aves WDR121 WD repeat domain 12 78.64(n)
    84.17(a)
      424089  XM_421945.4  XP_421945.4 
    lizard
    (Anolis carolinensis)
    Reptilia WDR126
    WD repeat domain 12
    85(a)
    1 ↔ 1
    GL343208.1(3568522-3585851)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.61342 Xenopus laevis transcribed sequence with moderate similarity more 76.92(n)    48018598 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb24f092 wufb24f09 77.12(n)   321652  BC044198.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67241 , 3 CG67241 41(a)3
    50.46(n)1
    42.89(a)1
      32A53
    344881  NM_135608.31  NP_609452.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F55F8.53
    tag-3451
    tag-3451 31(a)3
    44.87(n)1
    33.84(a)1
      I(5656070-5657913)3
    1722261  NM_059254.51  NP_491655.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YTM1(YOR272W)4
    YTM11
    Constituent of 66S pre-ribosomal particles, forms a more4
    YTM11
    45.12(n)1
    34.34(a)1
      15(832813-834195)4
    8544461, 4  NP_014915.31  NP_014915.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G155501 AT5G15550 47(n)
    34.81(a)
      831408  NM_121559.2  NP_197059.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g06004001 Os07g0600400 46.53(n)
    35.64(a)
      4343819  NM_001066732.1  NP_001060197.1 


    ENSEMBL Gene Tree for WDR12 (if available)
    TreeFam Gene Tree for WDR12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR12 gene
    WDR372  

    Find genes that share paralogs with WDR12           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for WDR12
    PGOHUM00000239533 PGOHUM00000246941 PGOHUM00000246013


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR12 (see all 610)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1129561551,2
    C--203745185(+) AGAATT/CGATTG 1 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs67223321,2
    C,F,H--203745327(+) ATACCT/CTTAAA 1 -- ut3115Minor allele frequency- C:0.06NS EA NA 2220
    rs1427455901,2
    C--203745385(+) TGCCAC/TAGTTT 1 -- ut310--------
    rs1995925451,2
    --203745570(+) TCAAAC/TTATTG 1 -- ut310--------
    rs1383973081,2
    C--203745597(+) AACATG/AGGAAG 2 /H /Y mis11Minor allele frequency- A:0.00NA 4544
    rs2019210721,2
    --203745699(+) TAAATA/GAATAT 1 -- int10--------
    rs775127161,2
    C,F--203745789(+) TTGCAT/CTGAGA 1 -- int11Minor allele frequency- C:0.02EA 120
    rs67258871,2
    C,F,A,H--203745885(+) AGACAT/CAATAT 1 -- int122Minor allele frequency- C:0.06NS EA NA 2662
    rs1814935261,2
    --203745922(+) GCCAAG/TATACA 1 -- int10--------
    rs1848969001,2
    --203745945(+) GGATAC/TAGTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for WDR12 (203739505 - 203879521 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for WDR12:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875715CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR12
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with WDR12           About GenesLikeMe

    Genetic Association Database (GAD): WDR12
    Human Genome Epidemiology (HuGE) Navigator: WDR12 (4 documents)

    Export disorders for WDR12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR12 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with WDR12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. (PubMed id 17353269)1, 2, 3 Rohrmoser M.... Eick D. (Mol. Cell. Biol. 2007)
    2. Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. (PubMed id 16043514)1, 2, 3 Hoelzel M.... Eick D. (J. Cell Biol. 2005)
    3. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PubMed id 21378990)1, 4 Schunkert H....Samani N.J. (Nat. Genet. 2011)
    4. A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. (PubMed id 20971364)1, 4 Ripatti S....Kathiresan S. (Lancet 2010)
    5. Additive effect of multiple genetic variants on the risk of coronary artery disease. (PubMed id 20738937)1, 4 LluA-s-Ganella C....Elosua R. (Rev Esp Cardiol 2010)
    6. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. (PubMed id 19198609)1, 4  ....Altshuler D. (Nat. Genet. 2009)
    7. Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex. (PubMed id 16738141)1, 2 Grimm T.... Eick D. (Nucleic Acids Res. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55759 HGNC: 14098 AceView: WDR12 Ensembl:ENSG00000138442 euGenes: HUgn55759
    ECgene: WDR12 H-InvDB: WDR12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WDR12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDR12 gene:
    Search GeneIP for patents involving WDR12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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