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Aliases for WDR12 Gene

Aliases for WDR12 Gene

  • WD Repeat Domain 12 2 3
  • WD Repeat-Containing Protein 12 3 4
  • Ribosome Biogenesis Protein WDR12 3
  • YTM1 3

External Ids for WDR12 Gene

Previous GeneCards Identifiers for WDR12 Gene

  • GC02M201962
  • GC02M202469
  • GC02M203709
  • GC02M203947
  • GC02M203570
  • GC02M203453
  • GC02M195592

Summaries for WDR12 Gene

Entrez Gene Summary for WDR12 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.[provided by RefSeq, Dec 2008]

GeneCards Summary for WDR12 Gene

WDR12 (WD Repeat Domain 12) is a Protein Coding gene. Among its related pathways are Notch signaling pathway (KEGG). An important paralog of this gene is WDR37.

UniProtKB/Swiss-Prot for WDR12 Gene

  • Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Gene Wiki entry for WDR12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR12 Gene

Genomics for WDR12 Gene

Regulatory Elements for WDR12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WDR12 Gene

Start:
202,874,782 bp from pter
End:
203,014,798 bp from pter
Size:
140,017 bases
Orientation:
Minus strand

Genomic View for WDR12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR12 Gene

Proteins for WDR12 Gene

  • Protein details for WDR12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZL7-WDR12_HUMAN
    Recommended name:
    Ribosome biogenesis protein WDR12
    Protein Accession:
    Q9GZL7
    Secondary Accessions:
    • B3KPA9
    • Q96HU0
    • Q9NV80
    • Q9NYI8

    Protein attributes for WDR12 Gene

    Size:
    423 amino acids
    Molecular mass:
    47708 Da
    Quaternary structure:
    • Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.

neXtProt entry for WDR12 Gene

Proteomics data for WDR12 Gene at MOPED

Post-translational modifications for WDR12 Gene

  • Ubiquitination at Lys203
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR12 Gene

Domains for WDR12 Gene

Gene Families for WDR12 Gene

HGNC:
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for WDR12 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZL7

UniProtKB/Swiss-Prot:

WDR12_HUMAN :
  • Q9GZL7
Family:
  • Belongs to the WD repeat WDR12/YTM1 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR12: view

Function for WDR12 Gene

Molecular function for WDR12 Gene

UniProtKB/Swiss-Prot Function: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
UniProtKB/Swiss-Prot Induction: By MYC.

Gene Ontology (GO) - Molecular Function for WDR12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16043514
GO:0043021 ribonucleoprotein complex binding IEA --
genes like me logo Genes that share ontologies with WDR12: view

Phenotypes for WDR12 Gene

GenomeRNAi human phenotypes for WDR12:
genes like me logo Genes that share phenotypes with WDR12: view

Animal Model Products

CRISPR Products

miRNA for WDR12 Gene

miRTarBase miRNAs that target WDR12

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDR12 Gene

Localization for WDR12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR12 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR12 Gene COMPARTMENTS Subcellular localization image for WDR12 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for WDR12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA 16043514
GO:0005730 nucleolus IDA 16043514
GO:0030687 preribosome, large subunit precursor IDA 17353269
GO:0070545 PeBoW complex IDA 16043514
genes like me logo Genes that share ontologies with WDR12: view

Pathways for WDR12 Gene

SuperPathways for WDR12 Gene

genes like me logo Genes that share pathways with WDR12: view

Pathways by source for WDR12 Gene

1 BioSystems pathway for WDR12 Gene

Gene Ontology (GO) - Biological Process for WDR12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP 16043514
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP 16043514
GO:0007219 Notch signaling pathway IEA --
GO:0008283 cell proliferation IMP 16043514
GO:0042273 ribosomal large subunit biogenesis IC 16043514
genes like me logo Genes that share ontologies with WDR12: view

Transcripts for WDR12 Gene

Unigene Clusters for WDR12 Gene

WD repeat domain 12:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR12

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for WDR12 Gene

GeneLoc Exon Structure for
WDR12
ECgene alternative splicing isoforms for
WDR12

Expression for WDR12 Gene

mRNA expression in normal human tissues for WDR12 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR12 Gene

SOURCE GeneReport for Unigene cluster for WDR12 Gene Hs.73291

genes like me logo Genes that share expressions with WDR12: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR12 Gene

Orthologs for WDR12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR12 35
  • 99.92 (n)
  • 100 (a)
WDR12 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR12 35
  • 92.51 (n)
  • 95.98 (a)
WDR12 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR12 35
  • 92.67 (n)
  • 95.04 (a)
WDR12 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr12 35
  • 89.6 (n)
  • 93.85 (a)
Wdr12 16
Wdr12 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia WDR12 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr12 35
  • 88.49 (n)
  • 93.38 (a)
chicken
(Gallus gallus)
Aves WDR12 35
  • 78.64 (n)
  • 84.17 (a)
WDR12 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR12 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6134 35
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr12 35
  • 74.39 (n)
  • 81.56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4439 35
zebrafish
(Danio rerio)
Actinopterygii wdr12 35
  • 73.22 (n)
  • 77.73 (a)
wdr12 36
  • 78 (a)
OneToOne
wufb24f09 35
African malaria mosquito
(Anopheles gambiae)
Insecta WDR12_ANOGA 35
  • 51.32 (n)
  • 46.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6724 35
  • 50.46 (n)
  • 42.89 (a)
CG6724 36
  • 41 (a)
OneToOne
CG6724 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea tag-345 35
  • 44.87 (n)
  • 33.84 (a)
tag-345 36
  • 30 (a)
ManyToMany
F55F8.5 37
  • 31 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER337W 35
  • 42.91 (n)
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTM1 35
  • 45.12 (n)
  • 34.34 (a)
YTM1 36
  • 27 (a)
OneToMany
YTM1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07425g 35
  • 45.54 (n)
  • 32.58 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G15550 35
  • 47 (n)
  • 34.81 (a)
rice
(Oryza sativa)
Liliopsida Os07g0600400 35
  • 46.53 (n)
  • 35.64 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC890.04c 35
  • 42.69 (n)
  • 33.67 (a)
Species with no ortholog for WDR12:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR12 Gene

ENSEMBL:
Gene Tree for WDR12 (if available)
TreeFam:
Gene Tree for WDR12 (if available)

Paralogs for WDR12 Gene

Paralogs for WDR12 Gene

Pseudogenes.org Pseudogenes for WDR12 Gene

genes like me logo Genes that share paralogs with WDR12: view

Variants for WDR12 Gene

Sequence variations from dbSNP and Humsavar for WDR12 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1820930 -- 202,887,127(-) AGAGT(C/T)GCTTG intron-variant
rs2043849 -- 202,886,008(+) GCTAC(C/G)ATCAC intron-variant
rs2082142 -- 202,902,901(+) gaaac(C/T)ccgtc intron-variant
rs2351520 -- 202,887,305(+) AGGTG(A/C)CCCAC intron-variant
rs2351521 -- 202,899,100(+) tgcag(G/T)ggggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR12 Gene

Variant ID Type Subtype PubMed ID
nsv875715 CNV Loss 21882294

Relevant External Links for WDR12 Gene

HapMap Linkage Disequilibrium report
WDR12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR12 Gene

Disorders for WDR12 Gene

Relevant External Links for WDR12

Genetic Association Database (GAD)
WDR12
Human Genome Epidemiology (HuGE) Navigator
WDR12
genes like me logo Genes that share disorders with WDR12: view

No data available for UniProtKB/Swiss-Prot for WDR12 Gene

Publications for WDR12 Gene

  1. Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. (PMID: 16043514) Hoelzel M. … Eick D. (J. Cell Biol. 2005) 2 3 4
  2. Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. (PMID: 17353269) Rohrmoser M. … Eick D. (Mol. Cell. Biol. 2007) 2 3 4
  3. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. (PMID: 19198609) . … Altshuler D. (Nat. Genet. 2009) 3 48
  4. Additive effect of multiple genetic variants on the risk of coronary artery disease. (PMID: 20738937) LluA-s-Ganella C. … Elosua R. (Rev Esp Cardiol 2010) 3 48
  5. A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. (PMID: 20971364) Ripatti S. … Kathiresan S. (Lancet 2010) 3 48

Products for WDR12 Gene

Sources for WDR12 Gene

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