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Aliases for WDR12 Gene

Aliases for WDR12 Gene

  • WD Repeat Domain 12 2 3 5
  • WD Repeat-Containing Protein 12 3 4
  • YTM1 3

External Ids for WDR12 Gene

Previous GeneCards Identifiers for WDR12 Gene

  • GC02M201962
  • GC02M202469
  • GC02M203709
  • GC02M203947
  • GC02M203570
  • GC02M203453
  • GC02M195592

Summaries for WDR12 Gene

Entrez Gene Summary for WDR12 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.[provided by RefSeq, Dec 2008]

GeneCards Summary for WDR12 Gene

WDR12 (WD Repeat Domain 12) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include ribonucleoprotein complex binding. An important paralog of this gene is WDR37.

UniProtKB/Swiss-Prot for WDR12 Gene

  • Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Gene Wiki entry for WDR12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR12 Gene

Genomics for WDR12 Gene

Regulatory Elements for WDR12 Gene

Enhancers for WDR12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR12 on UCSC Golden Path with GeneCards custom track

Promoters for WDR12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR12 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR12 Gene

Chromosome:
2
Start:
202,874,782 bp from pter
End:
203,014,798 bp from pter
Size:
140,017 bases
Orientation:
Minus strand

Genomic View for WDR12 Gene

Genes around WDR12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR12 Gene

Proteins for WDR12 Gene

  • Protein details for WDR12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZL7-WDR12_HUMAN
    Recommended name:
    Ribosome biogenesis protein WDR12
    Protein Accession:
    Q9GZL7
    Secondary Accessions:
    • B3KPA9
    • Q96HU0
    • Q9NV80
    • Q9NYI8

    Protein attributes for WDR12 Gene

    Size:
    423 amino acids
    Molecular mass:
    47708 Da
    Quaternary structure:
    • Component of the PeBoW complex, composed of BOP1, PES1 and WDR12 (ECO:0000269 PubMed:16043514, ECO:0000269 PubMed:16738141, PubMed:17189298, ECO:0000269 PubMed:17353269). The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The PeBoW complex associates with the 66S pre-ribosome (By similarity).

neXtProt entry for WDR12 Gene

Proteomics data for WDR12 Gene at MOPED

Post-translational modifications for WDR12 Gene

  • Ubiquitination at Lys 203
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for WDR12 Gene

Domains & Families for WDR12 Gene

Gene Families for WDR12 Gene

Suggested Antigen Peptide Sequences for WDR12 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZL7

UniProtKB/Swiss-Prot:

WDR12_HUMAN :
  • Belongs to the WD repeat WDR12/YTM1 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat WDR12/YTM1 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR12: view

Function for WDR12 Gene

Molecular function for WDR12 Gene

UniProtKB/Swiss-Prot Function:
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
UniProtKB/Swiss-Prot Induction:
By MYC.
genes like me logo Genes that share phenotypes with WDR12: view

Animal Models for WDR12 Gene

MGI Knock Outs for WDR12:

Animal Model Products

miRNA for WDR12 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR12 Gene

Localization for WDR12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR12 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR12 Gene COMPARTMENTS Subcellular localization image for WDR12 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for WDR12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030687 preribosome, large subunit precursor IDA 17353269
genes like me logo Genes that share ontologies with WDR12: view

Pathways & Interactions for WDR12 Gene

genes like me logo Genes that share pathways with WDR12: view

Pathways by source for WDR12 Gene

1 BioSystems pathway for WDR12 Gene

Gene Ontology (GO) - Biological Process for WDR12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP 16043514
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with WDR12: view

No data available for SIGNOR curated interactions for WDR12 Gene

Drugs & Compounds for WDR12 Gene

No Compound Related Data Available

Transcripts for WDR12 Gene

Unigene Clusters for WDR12 Gene

WD repeat domain 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for WDR12 Gene

GeneLoc Exon Structure for
WDR12
ECgene alternative splicing isoforms for
WDR12

Expression for WDR12 Gene

mRNA expression in normal human tissues for WDR12 Gene

Protein differential expression in normal tissues from HIPED for WDR12 Gene

This gene is overexpressed in CD8 Tcells (11.0), Testis (8.2), Peripheral blood mononuclear cells (6.4), and Lung (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR12 Gene



SOURCE GeneReport for Unigene cluster for WDR12 Gene Hs.73291

genes like me logo Genes that share expression patterns with WDR12: view

Protein tissue co-expression partners for WDR12 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR12 Gene

Orthologs for WDR12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR12 35
  • 92.51 (n)
  • 95.98 (a)
WDR12 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR12 35
  • 92.67 (n)
  • 95.04 (a)
WDR12 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr12 35
  • 89.6 (n)
  • 93.85 (a)
Wdr12 16
Wdr12 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR12 35
  • 99.92 (n)
  • 100 (a)
WDR12 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr12 35
  • 88.49 (n)
  • 93.38 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia WDR12 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR12 35
  • 78.64 (n)
  • 84.17 (a)
WDR12 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR12 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr12 35
  • 74.39 (n)
  • 81.56 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6134 35
zebrafish
(Danio rerio)
Actinopterygii wdr12 35
  • 73.22 (n)
  • 77.73 (a)
wufb24f09 35
wdr12 36
  • 78 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4439 35
fruit fly
(Drosophila melanogaster)
Insecta CG6724 37
  • 41 (a)
CG6724 35
  • 50.46 (n)
  • 42.89 (a)
CG6724 36
  • 41 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta WDR12_ANOGA 35
  • 51.32 (n)
  • 46.78 (a)
worm
(Caenorhabditis elegans)
Secernentea F55F8.5 37
  • 31 (a)
tag-345 35
  • 44.87 (n)
  • 33.84 (a)
tag-345 36
  • 30 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER337W 35
  • 42.91 (n)
  • 33 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07425g 35
  • 45.54 (n)
  • 32.58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTM1 35
  • 45.12 (n)
  • 34.34 (a)
YTM1 36
  • 27 (a)
OneToMany
YTM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G15550 35
  • 47 (n)
  • 34.81 (a)
rice
(Oryza sativa)
Liliopsida Os07g0600400 35
  • 46.53 (n)
  • 35.64 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC890.04c 35
  • 42.69 (n)
  • 33.67 (a)
Species with no ortholog for WDR12:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR12 Gene

ENSEMBL:
Gene Tree for WDR12 (if available)
TreeFam:
Gene Tree for WDR12 (if available)

Paralogs for WDR12 Gene

Paralogs for WDR12 Gene

Pseudogenes.org Pseudogenes for WDR12 Gene

genes like me logo Genes that share paralogs with WDR12: view

Variants for WDR12 Gene

Sequence variations from dbSNP and Humsavar for WDR12 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_012863 -
VAR_012864 -
VAR_012865 -
rs35212307 - 202,901,033(+) TGAGA(C/T)GTTCT reference, missense, utr-variant-5-prime
rs1820930 -- 202,887,127(-) AGAGT(C/T)GCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR12 Gene

Variant ID Type Subtype PubMed ID
nsv875715 CNV Loss 21882294

Variation tolerance for WDR12 Gene

Residual Variation Intolerance Score: 63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR12 Gene

HapMap Linkage Disequilibrium report
WDR12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR12 Gene

Disorders for WDR12 Gene

Relevant External Links for WDR12

Genetic Association Database (GAD)
WDR12
Human Genome Epidemiology (HuGE) Navigator
WDR12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR12

No disorders were found for WDR12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR12 Gene

Publications for WDR12 Gene

  1. Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. (PMID: 17353269) Rohrmoser M. … Eick D. (Mol. Cell. Biol. 2007) 2 3 4 67
  2. Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. (PMID: 16043514) Hoelzel M. … Eick D. (J. Cell Biol. 2005) 2 3
  3. The Crystal Structure of the Ubiquitin-like Domain of Ribosome Assembly Factor Ytm1 and Characterization of Its Interaction with the AAA-ATPase Midasin. (PMID: 26601951) Romes E.M. … Stanley R.E. (J. Biol. Chem. 2016) 3
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  5. DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex. (PMID: 25825154) Kellner M. … Eick D. (Exp. Cell Res. 2015) 3

Products for WDR12 Gene

Sources for WDR12 Gene

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