Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDR12 Gene

Aliases for WDR12 Gene

  • WD Repeat Domain 12 2 3 5
  • WD Repeat-Containing Protein 12 3 4
  • Ribosome Biogenesis Protein WDR12 3
  • YTM1 3

External Ids for WDR12 Gene

Previous GeneCards Identifiers for WDR12 Gene

  • GC02M201962
  • GC02M202469
  • GC02M203709
  • GC02M203947
  • GC02M203570
  • GC02M203453
  • GC02M195592

Summaries for WDR12 Gene

Entrez Gene Summary for WDR12 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.[provided by RefSeq, Dec 2008]

GeneCards Summary for WDR12 Gene

WDR12 (WD Repeat Domain 12) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include ribonucleoprotein complex binding. An important paralog of this gene is WDR37.

UniProtKB/Swiss-Prot for WDR12 Gene

  • Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Gene Wiki entry for WDR12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR12 Gene

Genomics for WDR12 Gene

Regulatory Elements for WDR12 Gene

Enhancers for WDR12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F202932 0.9 ENCODE 11 +81.8 81826 1.4 JUND STAT1 NBEAL1 CARF WDR12 LOC100887068 GC02M202945
GH02F202965 1.3 FANTOM5 Ensembl ENCODE 10.9 +49.1 49056 1.2 HDAC1 PKNOX1 CBX3 CREB3L1 CHAMP1 CREM USF2 JUNB TBX21 CREB3 NBEAL1 WDR12 CARF ICA1L GC02M202945 GC02P202987
GH02F202668 0.9 Ensembl ENCODE 10.2 +345.0 345025 1.9 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 SLC30A9 GLIS2 FAM117B CARF WDR12 ALS2 GC02P202671
GH02F202664 1.3 Ensembl ENCODE 10.2 +348.1 348098 3.8 TBL1XR1 BMI1 RAD21 ZBTB40 YY1 ZNF121 ETV6 ZNF652 SP3 MTA2 FAM117B CARF WDR12 ICA1L ALS2 LOC442063 GC02P202671
GH02F203013 0.2 ENCODE 0.8 -0.7 -693 4.0 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS NBEAL1 NOP58 WDR12 RPL7P14
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around WDR12 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR12 Gene

Chromosome:
2
Start:
202,874,782 bp from pter
End:
203,014,798 bp from pter
Size:
140,017 bases
Orientation:
Minus strand

Genomic View for WDR12 Gene

Genes around WDR12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR12 Gene

Proteins for WDR12 Gene

  • Protein details for WDR12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZL7-WDR12_HUMAN
    Recommended name:
    Ribosome biogenesis protein WDR12
    Protein Accession:
    Q9GZL7
    Secondary Accessions:
    • B3KPA9
    • Q96HU0
    • Q9NV80
    • Q9NYI8

    Protein attributes for WDR12 Gene

    Size:
    423 amino acids
    Molecular mass:
    47708 Da
    Quaternary structure:
    • Component of the PeBoW complex, composed of BOP1, PES1 and WDR12 (ECO:0000269 PubMed:16043514, ECO:0000269 PubMed:16738141, PubMed:17189298, ECO:0000269 PubMed:17353269). The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The PeBoW complex associates with the 66S pre-ribosome (By similarity).

neXtProt entry for WDR12 Gene

Post-translational modifications for WDR12 Gene

  • Ubiquitination at Lys 203
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR12 Gene

Domains & Families for WDR12 Gene

Gene Families for WDR12 Gene

Suggested Antigen Peptide Sequences for WDR12 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZL7

UniProtKB/Swiss-Prot:

WDR12_HUMAN :
  • Belongs to the WD repeat WDR12/YTM1 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat WDR12/YTM1 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR12: view

Function for WDR12 Gene

Molecular function for WDR12 Gene

UniProtKB/Swiss-Prot Function:
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
UniProtKB/Swiss-Prot Induction:
By MYC.

Gene Ontology (GO) - Molecular Function for WDR12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16043514
GO:0043021 ribonucleoprotein complex binding IEA --
genes like me logo Genes that share ontologies with WDR12: view
genes like me logo Genes that share phenotypes with WDR12: view

Animal Models for WDR12 Gene

MGI Knock Outs for WDR12:

Animal Model Products

miRNA for WDR12 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR12 Gene

Localization for WDR12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR12 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR12 Gene COMPARTMENTS Subcellular localization image for WDR12 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for WDR12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 16043514
GO:0030687 preribosome, large subunit precursor IDA 17353269
GO:0070545 PeBoW complex IDA 16043514
genes like me logo Genes that share ontologies with WDR12: view

Pathways & Interactions for WDR12 Gene

genes like me logo Genes that share pathways with WDR12: view

Gene Ontology (GO) - Biological Process for WDR12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP 16043514
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP 16043514
GO:0006364 rRNA processing TAS --
GO:0007219 Notch signaling pathway IEA --
GO:0008283 cell proliferation IMP 16043514
genes like me logo Genes that share ontologies with WDR12: view

No data available for SIGNOR curated interactions for WDR12 Gene

Transcripts for WDR12 Gene

Unigene Clusters for WDR12 Gene

WD repeat domain 12:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for WDR12 Gene

GeneLoc Exon Structure for
WDR12
ECgene alternative splicing isoforms for
WDR12

Expression for WDR12 Gene

mRNA expression in normal human tissues for WDR12 Gene

Protein differential expression in normal tissues from HIPED for WDR12 Gene

This gene is overexpressed in CD8 Tcells (11.0), Testis (8.2), Peripheral blood mononuclear cells (6.4), and Lung (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR12 Gene



Protein tissue co-expression partners for WDR12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR12 Gene:

WDR12

SOURCE GeneReport for Unigene cluster for WDR12 Gene:

Hs.73291
genes like me logo Genes that share expression patterns with WDR12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR12 Gene

Orthologs for WDR12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR12 34 35
  • 99.92 (n)
dog
(Canis familiaris)
Mammalia WDR12 34 35
  • 92.67 (n)
cow
(Bos Taurus)
Mammalia WDR12 34 35
  • 92.51 (n)
mouse
(Mus musculus)
Mammalia Wdr12 34 16 35
  • 89.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR12 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr12 34
  • 88.49 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 85 (a)
OneToMany
-- 35
  • 74 (a)
OneToMany
chicken
(Gallus gallus)
Aves WDR12 34 35
  • 78.64 (n)
lizard
(Anolis carolinensis)
Reptilia WDR12 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr12 34
  • 74.39 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6134 34
zebrafish
(Danio rerio)
Actinopterygii wdr12 34 35
  • 73.22 (n)
wufb24f09 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4439 34
African malaria mosquito
(Anopheles gambiae)
Insecta WDR12_ANOGA 34
  • 51.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6724 36 34 35
  • 50.46 (n)
worm
(Caenorhabditis elegans)
Secernentea tag-345 34 35
  • 44.87 (n)
F55F8.5 36
  • 31 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07425g 34
  • 45.54 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTM1 34 35 37
  • 45.12 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER337W 34
  • 42.91 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G15550 34
  • 47 (n)
rice
(Oryza sativa)
Liliopsida Os07g0600400 34
  • 46.53 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC890.04c 34
  • 42.69 (n)
Species where no ortholog for WDR12 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR12 Gene

ENSEMBL:
Gene Tree for WDR12 (if available)
TreeFam:
Gene Tree for WDR12 (if available)

Paralogs for WDR12 Gene

Paralogs for WDR12 Gene

Pseudogenes.org Pseudogenes for WDR12 Gene

genes like me logo Genes that share paralogs with WDR12: view

Variants for WDR12 Gene

Sequence variations from dbSNP and Humsavar for WDR12 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10168412 -- 202,900,783(+) TCACA(A/C)AAAAA intron-variant
rs10173454 -- 202,907,094(+) CAGGC(A/C)TGTGC intron-variant
rs10175671 -- 202,889,991(+) ggagg(C/G)tgagg intron-variant
rs10185482 -- 202,889,751(+) CTCTT(A/T)AAAAA intron-variant
rs10186316 -- 202,886,521(+) cccag(A/C)acttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR12 Gene

Variant ID Type Subtype PubMed ID
esv3594003 CNV gain 21293372
nsv1001799 CNV gain 25217958

Variation tolerance for WDR12 Gene

Residual Variation Intolerance Score: 63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR12 Gene

Disorders for WDR12 Gene

Relevant External Links for WDR12

Genetic Association Database (GAD)
WDR12
Human Genome Epidemiology (HuGE) Navigator
WDR12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR12

No disorders were found for WDR12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR12 Gene

Publications for WDR12 Gene

  1. Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. (PMID: 17353269) Rohrmoser M. … Eick D. (Mol. Cell. Biol. 2007) 2 3 4 64
  2. Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. (PMID: 16043514) Hoelzel M. … Eick D. (J. Cell Biol. 2005) 2 3 4 64
  3. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PMID: 21378990) Schunkert H. … Samani N.J. (Nat. Genet. 2011) 3 46 64
  4. Additive effect of multiple genetic variants on the risk of coronary artery disease. (PMID: 20738937) LluA-s-Ganella C. … Elosua R. (Rev Esp Cardiol 2010) 3 46 64
  5. A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. (PMID: 20971364) Ripatti S. … Kathiresan S. (Lancet 2010) 3 46 64

Products for WDR12 Gene

Sources for WDR12 Gene

Content
Loading form....