Aliases for WDR12 Gene
External Ids for WDR12 Gene
Previous GeneCards Identifiers for WDR12 Gene
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.[provided by RefSeq, Dec 2008]
GeneCards Summary for WDR12 Gene
WDR12 (WD Repeat Domain 12) is a Protein Coding gene. Among its related pathways are rRNA processing and Notch signaling pathway (KEGG). GO annotations related to this gene include ribonucleoprotein complex binding. An important paralog of this gene is WDR37.
UniProtKB/Swiss-Prot for WDR12 Gene
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.