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Aliases for WDR11 Gene

Aliases for WDR11 Gene

  • WD Repeat Domain 11 2 3 5
  • Bromodomain And WD Repeat-Containing Protein 2 3 4
  • Sensitization To Ricin Complex Subunit 1 2 3
  • WD Repeat-Containing Protein 15 3 4
  • BRWD2 3 4
  • WDR15 3 4
  • Bromodomain And WD Repeat Domain Containing 2 2
  • WD Repeat-Containing Protein 11 3
  • WD Repeat Domain 15 3
  • KIAA1351 4
  • DR11 3
  • HH14 3
  • SRI1 3

External Ids for WDR11 Gene

Previous HGNC Symbols for WDR11 Gene

  • BRWD2

Previous GeneCards Identifiers for WDR11 Gene

  • GC10P121529
  • GC10P121854
  • GC10P122741
  • GC10P122275
  • GC10P122600
  • GC10P116240
  • GC10P122610

Summaries for WDR11 Gene

Entrez Gene Summary for WDR11 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR11 Gene

WDR11 (WD Repeat Domain 11) is a Protein Coding gene. Diseases associated with WDR11 include Hypogonadotropic Hypogonadism 14 With Or Without Anosmia and Wdr11-Related Isolated Gonadotropin-Releasing Hormone Deficiency.

Gene Wiki entry for WDR11 Gene

Additional gene information for WDR11 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR11 Gene

Genomics for WDR11 Gene

Regulatory Elements for WDR11 Gene

Enhancers for WDR11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H120850 1.2 ENCODE 64.1 +0.6 592 2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 WDR11 SEC23IP WDR11-AS1 ENSG00000271670
GH10H121497 1 dbSUPER 69.5 +650.0 649984 8 PKNOX1 FEZF1 GLIS2 TSHZ1 ZNF662 ZNF491 GLIS1 ZNF624 ZNF300 WT1 WDR11 NSMCE4A RN7SKP167 FGFR2
GH10H121307 1 ENCODE 46.5 +457.6 457588 3 PKNOX1 ARNT ZNF133 FEZF1 ZNF2 ZNF121 GLIS2 ZNF302 KLF7 SP3 WDR11 LINC01153 RPL19P16 ENSG00000224250 NSMCE4A ATE1 LOC105378523 GC10M121233
GH10H120948 1.1 Ensembl ENCODE 41.1 +98.5 98481 1 RB1 KLF17 FEZF1 ZNF2 RAD21 GLIS2 ZNF143 ZNF391 ZNF202 ZNF654 WDR11 ENSG00000224250 LOC105378518 GC10P120938
GH10H121332 0.6 ENCODE 34.7 +482.1 482083 1 SMARCE1 DPF2 ZNF670 ZNF514 GATA3 CTBP1 ZNF747 CREB1 ZNF280C TCF7L2 WDR11 NSMCE4A RPL21P16 LOC105378523 GC10M121343
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR11 on UCSC Golden Path with GeneCards custom track

Promoters for WDR11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000034418 425 2001 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for WDR11 Gene

Chromosome:
10
Start:
120,851,175 bp from pter
End:
120,909,526 bp from pter
Size:
58,352 bases
Orientation:
Plus strand

Genomic View for WDR11 Gene

Genes around WDR11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR11 Gene

Proteins for WDR11 Gene

  • Protein details for WDR11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZH6-WDR11_HUMAN
    Recommended name:
    WD repeat-containing protein 11
    Protein Accession:
    Q9BZH6
    Secondary Accessions:
    • Q5VWA1
    • Q9P2J6

    Protein attributes for WDR11 Gene

    Size:
    1224 amino acids
    Molecular mass:
    136685 Da
    Quaternary structure:
    • Interacts with EMX1 (via the N-terminal and the central portion of the protein. The C-terminus does not.).
    SequenceCaution:
    • Sequence=BAA92589.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for WDR11 Gene

Post-translational modifications for WDR11 Gene

  • Ubiquitination at posLast=608608, Lys900, and Lys1193
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WDR11 Gene

Domains & Families for WDR11 Gene

Gene Families for WDR11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for WDR11 Gene

Suggested Antigen Peptide Sequences for WDR11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR11: view

No data available for UniProtKB/Swiss-Prot for WDR11 Gene

Function for WDR11 Gene

Phenotypes From GWAS Catalog for WDR11 Gene

Gene Ontology (GO) - Molecular Function for WDR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20887964
genes like me logo Genes that share ontologies with WDR11: view
genes like me logo Genes that share phenotypes with WDR11: view

Human Phenotype Ontology for WDR11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WDR11
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR11 Gene

Localization for WDR11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR11 Gene

Membrane; Single-pass membrane protein. Cytoplasm. Nucleus. Note=Might be shuttling between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR11 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
lysosome 5
nucleus 4
plasma membrane 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 20887964
GO:0005765 lysosomal membrane IDA 17897319
GO:0005829 cytosol IDA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with WDR11: view

Pathways & Interactions for WDR11 Gene

SuperPathways for WDR11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR11 Gene

Drugs & Compounds for WDR11 Gene

No Compound Related Data Available

Transcripts for WDR11 Gene

Unigene Clusters for WDR11 Gene

WD repeat domain 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WDR11
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for WDR11 Gene

No ASD Table

Relevant External Links for WDR11 Gene

GeneLoc Exon Structure for
WDR11
ECgene alternative splicing isoforms for
WDR11

Expression for WDR11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR11 Gene

Protein differential expression in normal tissues from HIPED for WDR11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.9) and Testis (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR11 Gene



Protein tissue co-expression partners for WDR11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR11 Gene:

WDR11

SOURCE GeneReport for Unigene cluster for WDR11 Gene:

Hs.144447

mRNA Expression by UniProt/SwissProt for WDR11 Gene:

Q9BZH6-WDR11_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for WDR11 Gene

  • Nervous system(4.8)
  • Liver(4.2)
  • Blood(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR11 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • eye
  • face
  • head
  • hypothalamus
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • olfactory bulb
  • pharynx
  • pituitary gland
  • skull
  • vocal cord
Thorax:
  • breast
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • kidney
Pelvis:
  • fallopian tube
  • ovary
  • pelvis
  • penis
  • prostate
  • testicle
  • uterus
  • vagina
  • vas deferens
  • vulva
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • hair
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with WDR11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WDR11 Gene

Orthologs for WDR11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR11 33 34
  • 99.78 (n)
cow
(Bos Taurus)
Mammalia BRWD2 34
  • 96 (a)
OneToOne
WDR11 33
  • 91.19 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR11 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR11 33 34
  • 91.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR11 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr11 33
  • 87.63 (n)
mouse
(Mus musculus)
Mammalia Wdr11 33 16 34
  • 87.29 (n)
chicken
(Gallus gallus)
Aves WDR11 33 34
  • 78.75 (n)
lizard
(Anolis carolinensis)
Reptilia WDR11 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr11 33
  • 71.28 (n)
Str.9308 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.2767 33
zebrafish
(Danio rerio)
Actinopterygii wdr11 33 34
  • 70.46 (n)
worm
(Caenorhabditis elegans)
Secernentea Y110A7A.9 33 34
  • 44.5 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G33530 33
  • 40.61 (n)
rice
(Oryza sativa)
Liliopsida Os02g0137000 33
  • 41.64 (n)
Species where no ortholog for WDR11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR11 Gene

ENSEMBL:
Gene Tree for WDR11 (if available)
TreeFam:
Gene Tree for WDR11 (if available)

Paralogs for WDR11 Gene

(1) SIMAP similar genes for WDR11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with WDR11: view

No data available for Paralogs for WDR11 Gene

Variants for WDR11 Gene

Sequence variations from dbSNP and Humsavar for WDR11 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs139007744 untested, Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) [MIM:614858] 120,906,788(+) TACTT(G/T)GATAG intron-variant, nc-transcript-variant, reference, missense
rs144440500 untested, Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) [MIM:614858] 120,871,218(+) TCTGC(A/G)GGAAG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs201051480 untested, Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) [MIM:614858] 120,866,757(+) ATTCA(C/T)GGAAC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs318240760 Pathogenic, Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) [MIM:614858] 120,871,178(+) AAAGT(A/C/G)CAATT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs318240761 untested, Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) [MIM:614858] 120,886,785(+) TATCA(A/T)CTCAC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for WDR11 Gene

Variant ID Type Subtype PubMed ID
esv2759784 CNV loss 17122850
esv3305638 CNV mobile element insertion 20981092
esv3406416 CNV insertion 20981092
esv3579148 CNV loss 25503493
esv3624737 CNV gain 21293372
nsv1043485 CNV loss 25217958
nsv428239 CNV gain+loss 18775914
nsv473863 CNV novel sequence insertion 20440878
nsv525609 CNV loss 19592680
nsv7573 CNV insertion 18451855

Variation tolerance for WDR11 Gene

Residual Variation Intolerance Score: 5.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR11 Gene

Human Gene Mutation Database (HGMD)
WDR11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR11 Gene

Disorders for WDR11 Gene

MalaCards: The human disease database

(6) MalaCards diseases for WDR11 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypogonadotropic hypogonadism 14 with or without anosmia
  • hh14
wdr11-related isolated gonadotropin-releasing hormone deficiency
  • hypogonadotropic hypogonadism 14 with or without anosmia
normosmic congenital hypogonadotropic hypogonadism
  • gonadotropic deficiency
kallmann syndrome
  • familial hypogonadism with anosmia
glioblastoma
  • glioblastoma multiforme
- elite association - COSMIC cancer census association via MalaCards
Search WDR11 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

WDR11_HUMAN
  • Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) [MIM:614858]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269 PubMed:20887964}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A chromosomal aberration involving WDR11 is found in a form of glioblastoma. Translocation t(10;19)(q26;q13.3) with ZNF320.
  • Note=A chromosomal aberration involving WDR11 is found in a form of Kallmann syndrome. Translocation 46,XY,t(10;12)(q26.12;q13.11).

Relevant External Links for WDR11

Genetic Association Database (GAD)
WDR11
Human Genome Epidemiology (HuGE) Navigator
WDR11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR11
genes like me logo Genes that share disorders with WDR11: view

No data available for Genatlas for WDR11 Gene

Publications for WDR11 Gene

  1. A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells. (PMID: 11536051) Chernova OB … Cowell JK (Oncogene 2001) 2 3 4 22 60
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  3. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. (PMID: 23394947) Bassik MC … Weissman JS (Cell 2013) 2 3 60
  4. WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome. (PMID: 20887964) Kim HG … Layman LC (American journal of human genetics 2010) 3 4 60
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 60

Products for WDR11 Gene

Sources for WDR11 Gene

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