WDR11 Gene
protein-coding GIFtS: 53
GCID: GC10P122600
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|
WD repeat domain 11(Previous name: bromodomain and WD repeat domain containing 2 )
(Previous symbol: BRWD2)
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Aliases
for WDR11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 111 2 | | Bromodomain And WD Repeat-Containing Protein 22 3 | | BRWD21 2 3 5 | | WD Repeat-Containing Protein 152 3 | | WDR151 2 3 | | FLJ105061 | | DR111 2 5 | | Bromodomain And WD Repeat Domain Containing 21 | | KIAA13511 3 5 | | WD Repeat Domain 152 | | HH141 2 | | WD Repeat-Containing Protein 112 |
Export aliases for WDR11 gene to outside databasesPrevious GC identifers: GC10P121529 GC10P121854 GC10P122741 GC10P122275 GC10P116240 |
Summaries
for WDR11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WDR11:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric ormultiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycleprogression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19)translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for thetumor suppressor locus. (provided by RefSeq, Jul 2008)
Gene Wiki entry for WDR11 (BRWD2)
|
Genomic Views
for WDR11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for WDR11
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26 Ensembl cytogenetic band: 10q26.12 HGNC cytogenetic band: 10q26WDR11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P122600: view genomic region
(about GC identifiers)
Start:
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122,610,687 bp from pter |
End:
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122,669,038 bp from pter |
Size:
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58,352 bases |
Orientation:
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plus strand |
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Proteins
for WDR11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR11_HUMAN, Q9BZH6 (See
protein sequence)Recommended Name: WD repeat-containing protein 11 Size: 1224 amino acids; 136685 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=BAA92589.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q5VWA1 Q9P2J6Explore the universe of human proteins at neXtProt for WDR11: NX_Q9BZH6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BZH6
WDR11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060587.8
ENSEMBL proteins: ENSP00000263461
Human Recombinant Protein Products for WDR11:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
WDR11 for ontologies About GeneDecksing
WDR11 Antibody Products:
Assay Products for WDR11: |
Protein
Domains /
Families
for WDR11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR11 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BZH6ProtoNet protein and cluster: Q9BZH6 UniProtKB/Swiss-Prot: WDR11_HUMAN, Q9BZH6Similarity: Contains 9 WD repeats |
Function
for WDR11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
WDR11 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for WDR11:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR11 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR11
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for WDR11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR11 |
|
Pathways & Interactions
for WDR11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR11
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/7 Interacting proteins for WDR11 (Q9BZH63 ENSP000002634614) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
|
Drugs & Compounds
for WDR11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR11
Search CenterWatch for drugs/clinical trials and news about WDR11
|
Transcripts
for WDR11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR11 gene: NM_018117.11 Unigene Cluster for WDR11: WD repeat domain 11 Hs.144447 [show with all ESTs]Unigene Representative Sequence: AL1376995 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263461(uc010qte.2 uc021pzt.1) ENST00000470052 ENST00000497136(uc001lfd.1)
ENST00000462529 ENST00000478567
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR11 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR11
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WDR11 (NM_018117) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR11 |
Additional cDNA sequence: AB037772.2 AF320223.1 AK000579.1 AK001368.1 AK025050.1 AK092984.1 AK299524.1 AK301761.1 AK315145.1 AL137699.1 BC040469.1 BC071564.1 15 DOTS entries: DT.316698 DT.100781008 DT.100781006 DT.211849 DT.100781003 DT.100781007 DT.86844723 DT.91855659 DT.121264942 DT.40215187 DT.121264920 DT.121264983 DT.65284169 DT.92437188 DT.91850479 24/251 AceView cDNA sequences (see all 251): BM721711 AA969234 AI659435 BU619984 AA954748 AI569636 CA438540 AI160395 BM510690 AA769523 AI140912 BM750913 BF196913 AA366068 AA789241 AA284135 AW196880 AL519788 AA804424 BQ227421 AA716492 BF514904 BM477141 AA635830
GeneLoc Exon Structure
|
Expression
for WDR11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAAATAAAT
About this image
See WDR11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR11
SOURCE GeneReport for Unigene cluster: Hs.144447
UniProtKB/Swiss-Prot: WDR11_HUMAN, Q9BZH6Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Array including WDR11: | Epigenetic Chromatin Remodeling Factors in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR11 |
Orthologs
for WDR11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WDR11 gene from 8/21 species (see all 21) About this table
ENSEMBL Gene Tree for WDR11 (if available)
TreeFam Gene Tree for WDR11 (if available) |
Paralogs
for WDR11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for WDR11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR11 (122610687 - 122669038 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for WDR11
2 CNVs: 3822 34849
Human Gene Mutation Database (HGMD): WDR11
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR11 |
|
Disorders
/ Diseases
for WDR11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDR11 for disorders About GeneDecksing
OMIM gene information: 606417
OMIM disorders: --
UniProtKB/Swiss-Prot: WDR11_HUMAN, Q9BZH6
Note=A chromosomal aberration involving WDR11 is found in a form of glioblastoma. Translocationt(10;19)(q26;q13.3) with ZNF320
8  diseases for WDR11: About MalaCardsglioblastoma hypersensitivity reaction type ii disease alopecia universalis hypogonadotropism
hypogonadism alopecia alzheimer's disease schizophrenia
1 disease from the University of Copenhagen DISEASES database for WDR11:Hypersensitivity reaction type II disease Human Genome Epidemiology (HuGE) Navigator: WDR11 (1 document)
Export disorders for WDR11 gene to outside databases
|
Publications
for WDR11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR11 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with WDR11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells. (PubMed id 11536051)1, 2, 3, 9 Chernova O.B....Cowell J.K. (2001)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
- NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for WDR11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR11 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing WDR11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR11 gene:
Search GeneIP for patents involving WDR11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WDR11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDR11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR11 | | | OriGene Protein Over-expression Lysate for WDR11 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WDR11 | | OriGene 3'-UTR Clone for WDR11 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR11 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR11 |
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 | | | WDR11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR11 |
|  |  |  |  | | | | ThermoFisher Antibodies for WDR11 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR11 |
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