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Aliases for WDR11 Gene

Aliases for WDR11 Gene

  • WD Repeat Domain 11 2 3 5
  • Bromodomain And WD Repeat-Containing Protein 2 3 4
  • Sensitization To Ricin Complex Subunit 1 2 3
  • WD Repeat-Containing Protein 15 3 4
  • BRWD2 3 4
  • WDR15 3 4
  • Bromodomain And WD Repeat Domain Containing 2 2
  • WD Repeat Domain 15 3
  • KIAA1351 4
  • DR11 3
  • HH14 3
  • SRI1 3

External Ids for WDR11 Gene

Previous HGNC Symbols for WDR11 Gene

  • BRWD2

Previous GeneCards Identifiers for WDR11 Gene

  • GC10P121529
  • GC10P121854
  • GC10P122741
  • GC10P122275
  • GC10P122600
  • GC10P116240
  • GC10P122610

Summaries for WDR11 Gene

Entrez Gene Summary for WDR11 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR11 Gene

WDR11 (WD Repeat Domain 11) is a Protein Coding gene. Diseases associated with WDR11 include Hypogonadotropic Hypogonadism 14 With Or Without Anosmia and Wdr11-Related Isolated Gonadotropin-Releasing Hormone Deficiency.

Gene Wiki entry for WDR11 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR11 Gene

Genomics for WDR11 Gene

Regulatory Elements for WDR11 Gene

Enhancers for WDR11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR11 on UCSC Golden Path with GeneCards custom track

Promoters for WDR11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR11 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR11 Gene

120,851,175 bp from pter
120,909,526 bp from pter
58,352 bases
Plus strand

Genomic View for WDR11 Gene

Genes around WDR11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR11 Gene

Proteins for WDR11 Gene

  • Protein details for WDR11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 11
    Protein Accession:
    Secondary Accessions:
    • Q5VWA1
    • Q9P2J6

    Protein attributes for WDR11 Gene

    1224 amino acids
    Molecular mass:
    136685 Da
    Quaternary structure:
    • Interacts with EMX1 (via the N-terminal and the central portion of the protein. The C-terminus does not.).
    • Sequence=BAA92589.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for WDR11 Gene

Proteomics data for WDR11 Gene at MOPED

Post-translational modifications for WDR11 Gene

  • Ubiquitination at Lys 608, Lys 900, and Lys 1193
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR11 Gene

No data available for DME Specific Peptides for WDR11 Gene

Domains & Families for WDR11 Gene

Gene Families for WDR11 Gene

Protein Domains for WDR11 Gene

Suggested Antigen Peptide Sequences for WDR11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 9 WD repeats.
  • Contains 9 WD repeats.
genes like me logo Genes that share domains with WDR11: view

Function for WDR11 Gene

genes like me logo Genes that share phenotypes with WDR11: view

Human Phenotype Ontology for WDR11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR11 Gene

Localization for WDR11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR11 Gene

Membrane; Single-pass membrane protein. Cytoplasm. Nucleus. Note=Might be shuttling between the nucleus and the cytoplasm.

Subcellular locations from

Jensen Localization Image for WDR11 Gene COMPARTMENTS Subcellular localization image for WDR11 gene
Compartment Confidence
cytoskeleton 5
lysosome 5
vacuole 5
nucleus 4
cytosol 3
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for WDR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20887964
GO:0005765 lysosomal membrane IDA 17897319
GO:0015630 microtubule cytoskeleton IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with WDR11: view

Pathways & Interactions for WDR11 Gene

SuperPathways for WDR11 Gene

No Data Available

Interacting Proteins for WDR11 Gene

Gene Ontology (GO) - Biological Process for WDR11 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR11 Gene

Drugs & Compounds for WDR11 Gene

No Compound Related Data Available

Transcripts for WDR11 Gene

Unigene Clusters for WDR11 Gene

WD repeat domain 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR11 Gene

No ASD Table

Relevant External Links for WDR11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR11 Gene

mRNA expression in normal human tissues for WDR11 Gene

Protein differential expression in normal tissues from HIPED for WDR11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.9) and Testis (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR11 Gene

SOURCE GeneReport for Unigene cluster for WDR11 Gene Hs.144447

mRNA Expression by UniProt/SwissProt for WDR11 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with WDR11: view

Protein tissue co-expression partners for WDR11 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WDR11 Gene

Orthologs for WDR11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR11 35
  • 91.19 (n)
  • 96.64 (a)
BRWD2 36
  • 96 (a)
(Canis familiaris)
Mammalia WDR11 35
  • 91.39 (n)
  • 96.16 (a)
WDR11 36
  • 96 (a)
(Mus musculus)
Mammalia Wdr11 35
  • 87.29 (n)
  • 94.35 (a)
Wdr11 16
Wdr11 36
  • 94 (a)
(Pan troglodytes)
Mammalia WDR11 35
  • 99.78 (n)
  • 100 (a)
WDR11 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Wdr11 35
  • 87.63 (n)
  • 94.11 (a)
(Monodelphis domestica)
Mammalia WDR11 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia WDR11 36
  • 90 (a)
(Gallus gallus)
Aves WDR11 35
  • 78.75 (n)
  • 87.12 (a)
WDR11 36
  • 87 (a)
(Anolis carolinensis)
Reptilia WDR11 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9308 35
wdr11 35
  • 71.28 (n)
  • 80 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2767 35
(Danio rerio)
Actinopterygii wdr11 35
  • 70.46 (n)
  • 77.68 (a)
wdr11 36
  • 75 (a)
(Caenorhabditis elegans)
Secernentea Y110A7A.9 35
  • 44.5 (n)
  • 31.26 (a)
Y110A7A.9 36
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G33530 35
  • 40.61 (n)
  • 27.1 (a)
(Oryza sativa)
Liliopsida Os02g0137000 35
  • 41.64 (n)
  • 28.96 (a)
Species with no ortholog for WDR11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR11 Gene

Gene Tree for WDR11 (if available)
Gene Tree for WDR11 (if available)

Paralogs for WDR11 Gene

(1) SIMAP similar genes for WDR11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with WDR11: view

No data available for Paralogs for WDR11 Gene

Variants for WDR11 Gene

Sequence variations from dbSNP and Humsavar for WDR11 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs201051480 Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) 120,866,757(+) ATTCA(C/T)GGAAC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs318240760 Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) 120,871,178(+) AAAGT(A/C/G)CAATT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs144440500 Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) 120,871,218(+) TCTGC(A/G)GGAAG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs318240761 Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) 120,886,785(+) TATCA(A/T)CTCAC nc-transcript-variant, reference, missense
VAR_069198 -

Structural Variations from Database of Genomic Variants (DGV) for WDR11 Gene

Variant ID Type Subtype PubMed ID
nsv525609 CNV Loss 19592680
dgv321e1 CNV Complex 17122850
nsv428239 CNV Gain+Loss 18775914
nsv7573 CNV Insertion 18451855
esv269915 CNV Insertion 20981092

Variation tolerance for WDR11 Gene

Residual Variation Intolerance Score: 5.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR11 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR11 Gene

Disorders for WDR11 Gene

MalaCards: The human disease database

(8) MalaCards diseases for WDR11 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypogonadotropic hypogonadism 14 with or without anosmia
  • hh14
wdr11-related isolated gonadotropin-releasing hormone deficiency
  • hypogonadotropic hypogonadism 15 with or without anosmia
normosmic congenital hypogonadotropic hypogonadism
  • gonadotropic deficiency
kallmann syndrome
  • familial hypogonadism with anosmia
  • glioblastoma multiforme
- elite association - COSMIC cancer census association via MalaCards
Search WDR11 in MalaCards View complete list of genes associated with diseases


  • Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) [MIM:614858]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269 PubMed:20887964}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A chromosomal aberration involving WDR11 is found in a form of glioblastoma. Translocation t(10;19)(q26;q13.3) with ZNF320.
  • Note=A chromosomal aberration involving WDR11 is found in a form of Kallmann syndrome. Translocation 46,XY,t(10;12)(q26.12;q13.11).

Relevant External Links for WDR11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with WDR11: view

No data available for Genatlas for WDR11 Gene

Publications for WDR11 Gene

  1. A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells. (PMID: 11536051) Chernova O.B. … Cowell J.K. (Oncogene 2001) 2 3 4 23 67
  2. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. (PMID: 23394947) Bassik M.C. … Weissman J.S. (Cell 2013) 2 3
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Cellular Protein WDR11 Interacts with Specific Herpes Simplex Virus Proteins at the trans-Golgi Network To Promote Virus Replication. (PMID: 26178983) Taylor K.E. … Mossman K.L. (J. Virol. 2015) 3

Products for WDR11 Gene

Sources for WDR11 Gene