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Aliases for WDR11 Gene

Aliases for WDR11 Gene

  • WD Repeat Domain 11 2 3
  • BRWD2 3 4 6
  • Bromodomain And WD Repeat-Containing Protein 2 3 4
  • WD Repeat-Containing Protein 15 3 4
  • KIAA1351 4 6
  • WDR15 3 4
  • DR11 3 6
  • HH14 3 6
  • Bromodomain And WD Repeat Domain Containing 2 2
  • WD Repeat-Containing Protein 11 3
  • WD Repeat Domain 15 3

External Ids for WDR11 Gene

Previous HGNC Symbols for WDR11 Gene

  • BRWD2

Previous GeneCards Identifiers for WDR11 Gene

  • GC10P121529
  • GC10P121854
  • GC10P122741
  • GC10P122275
  • GC10P122600
  • GC10P116240
  • GC10P122610

Summaries for WDR11 Gene

Entrez Gene Summary for WDR11 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR11 Gene

WDR11 (WD Repeat Domain 11) is a Protein Coding gene. Diseases associated with WDR11 include hypogonadotropic hypogonadism 14 with or without anosmia and normosmic congenital hypogonadotropic hypogonadism.

Gene Wiki entry for WDR11 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR11 Gene

Genomics for WDR11 Gene

Genomic Location for WDR11 Gene

Start:
120,851,175 bp from pter
End:
120,909,526 bp from pter
Size:
58,352 bases
Orientation:
Plus strand

Genomic View for WDR11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR11 Gene

No data available for Regulatory Elements for WDR11 Gene

Proteins for WDR11 Gene

  • Protein details for WDR11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZH6-WDR11_HUMAN
    Recommended name:
    WD repeat-containing protein 11
    Protein Accession:
    Q9BZH6
    Secondary Accessions:
    • Q5VWA1
    • Q9P2J6

    Protein attributes for WDR11 Gene

    Size:
    1224 amino acids
    Molecular mass:
    136685 Da
    Quaternary structure:
    • Interacts with EMX1 (via the N-terminal and the central portion of the protein. The C-terminus does not.).
    SequenceCaution:
    • Sequence=BAA92589.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for WDR11 Gene

Proteomics data for WDR11 Gene at MOPED

Post-translational modifications for WDR11 Gene

  • Ubiquitination at Lys608, Lys900, and Lys1193
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR11 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for WDR11

No data available for DME Specific Peptides for WDR11 Gene

Domains for WDR11 Gene

Gene Families for WDR11 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for WDR11 Gene

Suggested Antigen Peptide Sequences for WDR11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZH6

UniProtKB/Swiss-Prot:

WDR11_HUMAN :
  • Q9BZH6
Similarity:
  • Contains 9 WD repeats.
genes like me logo Genes that share domains with WDR11: view

Function for WDR11 Gene

Gene Ontology (GO) - Molecular Function for WDR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20887964
genes like me logo Genes that share ontologies with WDR11: view

Phenotypes for WDR11 Gene

GenomeRNAi human phenotypes for WDR11:
genes like me logo Genes that share phenotypes with WDR11: view

Animal Model Products

CRISPR Products

miRNA for WDR11 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR11

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDR11 Gene

Localization for WDR11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR11 Gene

Membrane; Single-pass membrane protein. Cytoplasm. Nucleus. Note=Might be shuttling between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR11 Gene COMPARTMENTS Subcellular localization image for WDR11 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for WDR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005765 lysosomal membrane IDA 17897319
GO:0005929 cilium IEA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with WDR11: view

Pathways for WDR11 Gene

SuperPathways for WDR11 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Remodeling Factors in human,mouse,rat

Interacting Proteins for WDR11 Gene

Gene Ontology (GO) - Biological Process for WDR11 Gene

None

No data available for Pathways by source for WDR11 Gene

Transcripts for WDR11 Gene

Unigene Clusters for WDR11 Gene

WD repeat domain 11:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR11 Gene

No ASD Table

Relevant External Links for WDR11 Gene

GeneLoc Exon Structure for
WDR11
ECgene alternative splicing isoforms for
WDR11

Expression for WDR11 Gene

mRNA expression in normal human tissues for WDR11 Gene

Protein differential expression in normal tissues for WDR11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.9) and Testis (9.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR11 Gene

SOURCE GeneReport for Unigene cluster for WDR11 Gene Hs.144447

mRNA Expression by UniProt/SwissProt for WDR11 Gene

Q9BZH6-WDR11_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with WDR11: view

Expression partners for WDR11 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WDR11 Gene

Orthologs for WDR11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR11 35
  • 91.19 (n)
  • 96.64 (a)
BRWD2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR11 35
  • 91.39 (n)
  • 96.16 (a)
WDR11 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr11 35
  • 87.29 (n)
  • 94.35 (a)
Wdr11 16
Wdr11 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR11 35
  • 99.78 (n)
  • 100 (a)
WDR11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr11 35
  • 87.63 (n)
  • 94.11 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR11 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR11 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR11 35
  • 78.75 (n)
  • 87.12 (a)
WDR11 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR11 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9308 35
wdr11 35
  • 71.28 (n)
  • 80 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2767 35
zebrafish
(Danio rerio)
Actinopterygii wdr11 35
  • 70.46 (n)
  • 77.68 (a)
wdr11 36
  • 75 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y110A7A.9 35
  • 44.5 (n)
  • 31.26 (a)
Y110A7A.9 36
  • 27 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G33530 35
  • 40.61 (n)
  • 27.1 (a)
rice
(Oryza sativa)
Liliopsida Os02g0137000 35
  • 41.64 (n)
  • 28.96 (a)
Species with no ortholog for WDR11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR11 Gene

ENSEMBL:
Gene Tree for WDR11 (if available)
TreeFam:
Gene Tree for WDR11 (if available)

Paralogs for WDR11 Gene

Selected SIMAP similar genes for WDR11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with WDR11: view

No data available for Paralogs for WDR11 Gene

Variants for WDR11 Gene

Sequence variations from dbSNP and Humsavar for WDR11 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs10871 -- 120,909,209(-) GAAAA(A/C)AAAAA utr-variant-3-prime, nc-transcript-variant
rs754869 -- 120,896,206(+) AGCAC(A/G)TATAG intron-variant
rs754870 -- 120,896,372(+) cttct(C/G)tatct intron-variant
rs768798 -- 120,856,846(+) TTATT(C/T)GTGGT intron-variant
rs768799 -- 120,857,092(+) TATAT(A/G)TATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR11 Gene

Variant ID Type Subtype PubMed ID
nsv525609 CNV Loss 19592680
dgv321e1 CNV Complex 17122850
nsv428239 CNV Gain+Loss 18775914
nsv7573 CNV Insertion 18451855
esv269915 CNV Insertion 20981092

Relevant External Links for WDR11 Gene

HapMap Linkage Disequilibrium report
WDR11
Human Gene Mutation Database (HGMD)
WDR11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR11 Gene

Disorders for WDR11 Gene

(1) OMIM Diseases for WDR11 Gene (606417)

UniProtKB/Swiss-Prot

WDR11_HUMAN
  • Note=A chromosomal aberration involving WDR11 is found in a form of glioblastoma. Translocation t(10;19)(q26;q13.3) with ZNF320.
  • Note=A chromosomal aberration involving WDR11 is found in a form of Kallmann syndrome. Translocation 46,XY,t(10;12)(q26.12;q13.11).
  • Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) [MIM:614858]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269 PubMed:20887964}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for WDR11 Gene

Relevant External Links for WDR11

Genetic Association Database (GAD)
WDR11
Human Genome Epidemiology (HuGE) Navigator
WDR11
genes like me logo Genes that share disorders with WDR11: view

No data available for Novoseek inferred disease relationships and Genatlas for WDR11 Gene

Publications for WDR11 Gene

  1. A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells. (PMID: 11536051) Chernova O.B. … Cowell J.K. (Oncogene 2001) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome. (PMID: 20887964) Kim H.G. … Layman L.C. (Am. J. Hum. Genet. 2010) 3 4

Products for WDR11 Gene

Sources for WDR11 Gene

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