WDR1 Gene
protein-coding GIFtS: 54
GCID: GC04M010075
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|
WD repeat domain 1
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Aliases
for WDR1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 11 2 | | Actin-Interacting Protein 12 3 | | AIP12 3 | | NORI-12 3 | | WD Repeat-Containing Protein 12 |
Export aliases for WDR1 gene to outside databasesPrevious GC identifers: GC04M009744 GC04M010026 GC04M009826 GC04M009752 GC04M009685 GC04M009409 |
Summaries
for WDR1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WDR1:
This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domainscontaining several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved inprotein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcriptvariants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: WDR1_HUMAN, O75083Function: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity)
Gene Wiki entry for WDR1
|
Genomic Views
for WDR1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006316.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR1 gene promoter:
STAT5B STAT1 STAT4 STAT6 STAT1beta Olf-1 STAT5A STAT1alpha STAT2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.1 Ensembl cytogenetic band: 4p16.1 HGNC cytogenetic band: 4p16.1WDR1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M010075: view genomic region
(about GC identifiers)
Start:
|
10,075,963 bp from pter |
End:
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10,118,573 bp from pter |
Size:
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42,611 bases |
Orientation:
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minus strand |
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Proteins
for WDR1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR1_HUMAN, O75083 (See
protein sequence)Recommended Name: WD repeat-containing protein 1 Size: 606 amino acids; 66194 Da
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Sequence caution: Sequence=AAD05045.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: A8K6E9 A8MPU4 O75313 Q8N6E5 Q9UG05 Q9UG78 Q9UQE0Alternative splicing: 2 isoforms: O75083-1 O75083-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for WDR1: NX_O75083
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75083
WDR1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_005103.2 NP_059830.1
ENSEMBL proteins: ENSP00000427687 ENSP00000426725 ENSP00000425481 ENSP00000371890 ENSP00000371889 Reactome Protein details: O75083
Human Recombinant Protein Products for WDR1:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
WDR1 for ontologies About GeneDecksing
WDR1 Antibody Products:
Assay Products for WDR1: |
Protein
Domains /
Families
for WDR1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75083ProtoNet protein and cluster: O75083 1 Blocks protein family: IPB001680 G-protein beta WD-40 repeat signature
UniProtKB/Swiss-Prot: WDR1_HUMAN, O75083Similarity: Belongs to the WD repeat AIP1 familySimilarity: Contains 11 WD repeats |
Function
for WDR1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: WDR1_HUMAN, O75083Function: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity) Genatlas biochemistry entry for WDR1:WD repeat domain 1,homolog to a chick gene upregulated in the acoustically chick basilar papilla
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003779 | actin binding |
IEA | -- |
WDR1 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for WDR1:
9 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Wdr1):
WDR1 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for WDR1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR1 |
|
Pathways & Interactions
for WDR1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Platelet degranulation | | | 2 | Platelet activation, signaling and aggregation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for WDR1
WDR1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR1
5/38 Interacting proteins for WDR1 (O750832, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 38)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
WDR1 for ontologies About GeneDecksing
|
Drugs & Compounds
for WDR1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR1
Search CenterWatch for drugs/clinical trials and news about WDR1
|
Transcripts
for WDR1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR1 gene (2 alternative transcripts): NM_005112.4 NM_017491.3 Unigene Cluster for WDR1: WD repeat domain 1 Hs.128548 [show with all ESTs]Unigene Representative Sequence: BX64819018 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000499869 ENST00000502702 ENST00000515743(uc010idm.3 uc003gmh.2)
ENST00000502962(uc021xly.1) ENST00000504739 ENST00000506246 ENST00000505543
ENST00000508949 ENST00000510848 ENST00000509695 ENST00000508079 ENST00000264785
ENST00000505851 ENST00000514319 ENST00000515018 ENST00000509600 ENST00000382452(uc021xlv.1)
ENST00000382451(uc021xlw.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): WDR1 (NM_017491) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR1 |
Additional cDNA sequence: AB010427.2 AB209746.1 AF020056.1 AF020260.1 AF274954.1 AK127665.1 AK222764.1 AK222897.1 AK225276.1 AK291614.1 AK299602.1 AK302209.1 AK303132.1 AL050108.1 AL110208.1 AL832280.1 BC000201.1 BC002489.2 BC030541.2 BX648190.1 HQ013239.1 L32559.1 24/44 DOTS entries (see all 44): DT.101986430 DT.95282080 DT.85104817 DT.95152832 DT.95361722 DT.100846037 DT.100846013 DT.121218406 DT.91768579 DT.100846024 DT.100846028 DT.121218445 DT.100846029 DT.100846014 DT.121218328 DT.100846016 DT.121218425 DT.100846033 DT.40127487 DT.91640869 DT.95152831 DT.100846021 DT.405263 DT.95282079 24/806 AceView cDNA sequences (see all 806): BQ772816 CF785875 BG179003 BM905771 CR595687 CK430066 BE253443 AW995527 AA985176 BQ652690 AA364935 BM827413 BM988059 CA426181 BU071167 BX645584 BQ052419 AK127665 BM561734 BI222453 AA564117 BQ231580 BG388641 BI754853
GeneLoc Exon Structure
|
Expression
for WDR1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See WDR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR1
SOURCE GeneReport for Unigene cluster: Hs.128548
SABiosciences Custom PCR Arrays for WDR1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR1 |
Orthologs
for WDR1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WDR1 gene from 10/33 species (see all 33) About this table
ENSEMBL Gene Tree for WDR1 (if available)
TreeFam Gene Tree for WDR1 (if available) |
Paralogs
for WDR1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for WDR1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR1 (10075963 - 10118573 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for WDR1
4 CNVs: 68675 2070 8443 3479 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR1 |
|
Disorders
/ Diseases
for WDR1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDR1 for disorders About GeneDecksing
OMIM gene information: 604734
OMIM disorders: --
5  diseases for WDR1: About MalaCardsdown syndrome multiple sclerosis endocarditis conjunctivitis
schizophrenia
Export disorders for WDR1 gene to outside databases
|
Publications
for WDR1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR1 gene, integrated from 9 sources (see all 52):
(articles sorted by number of sources associating them with WDR1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein. (PubMed id 10036186)1, 2, 3 Adler H.J.... Lomax M.I. (1999)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- Critical roles of actin-interacting protein 1 in cytokinesis and chemotactic migration of mammalian cells. (PubMed id 18494608)1, 9 Kato A....Mizuno K. (2008)
- Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. (PubMed id 17293856)1, 9 Li J....Yuan J. (2007)
- AIP1/WDR1 supports mitotic cell rounding. (PubMed id 15629458)1, 9 Fujibuchi T....Kito K. (2005)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Genome-wide association of serum uric acid concentrati on: replication of sequence variants in an island population of the Adriatic coa st of Croatia. (PubMed id 22229870)1 Karns R....Deka R. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
|
External Searches for WDR1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR1 gene:
Search GeneIP for patents involving WDR1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for WDR1 | | OriGene Custom Protein Services for WDR1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR1 |
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 | | | WDR1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR1 |
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