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WDR1 Gene

protein-coding   GIFtS: 56

GC04M009685
WD repeat domain 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for WDR1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
AIP1 2, 3
NORI-1 2, 3
Descriptions
Actin-interacting protein 1 3
WD repeat domain 1 2
WD repeat-containing protein 1 2
actin interacting protein 1 2
External Ids
HGNC: 127541
Entrez Gene: 99482
UniProtKB: O750833
Ensembl: ENSG000000711277
Search outside databases for aliases for WDR1 gene

Previous GC identifers: GC04M009744 GC04M010026 GC04M009826 GC04M009752

Summaries
for WDR1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for WDR1:
This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino
acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal
end. WD domains are involved in protein-protein interactions. The encoded protein may help induce
the disassembly of actin filaments. Two transcript variants encoding different isoforms have been
found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: WDR1_HUMAN, O75083
Function: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins
(By similarity)

Gene Wiki entry for WDR1

Genomic Location
for WDR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WDR1 gene  

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

WDR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M009685:     (about GC identifiers)

Start:
 9,685,061 bp from pter
End:
 9,727,671 bp from pter
Size:
 42,611 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000004.10  NT_006316.15  

Proteins
for WDR1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: WDR1_HUMAN, O75083 (See protein sequence)
Recommended Name: WD repeat-containing protein 1  
Size: 606 amino acids; 66194 Da
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Secondary accessions: A8K6E9 O75313 Q8N6E5 Q9UG05 Q9UG78 Q9UQE0
Alternative splicing: 3 isoforms:  O75083-1   O75083-2   O75083-3   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_005103.2  NP_059830.1  


    ENSEMBL proteins: 
    ENSP00000264785 ENSP00000382881 ENSP00000371890 ENSP00000371889 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
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    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (WDR1)
    Human Recombinant Proteins from Abnova (WDR1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005856 cytoskeleton IEA--
    About this table

    Antibodies for WDR1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for WDR1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (WDR1), each with their AbpromiseSM
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    Search Novus for antibodies for WDR1

    Assays for WDR1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for WDR1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro domains/families (see all 6 ):
     IPR019782 WD40_repeat_2
     IPR019775 WD40_repeat_CS
     IPR019781 WD40_repeat_sg
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_region


       GeneDecks  WDR1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O75083

    ProtoNet protein and cluster: O75083

    1 Blocks protein family: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: WDR1_HUMAN, O75083
    Similarity: Belongs to the WD repeat AIP1 family
    Similarity: Contains 11 WD repeats

    Gene Function
    for WDR1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (WDR1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005112

                  Applied Biosystems Silencer® siRNAs for WDR1

                  Sigma-Aldrich siRNA and siRNA Panels for WDR1  
                         Sigma-Aldrich shRNA for WDR1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for WDR1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005112
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005112
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_005112 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_017491

    UniProtKB/Swiss-Prot: WDR1_HUMAN, O75083
    Function: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins
    (By similarity)

    Genatlas biochemistry entry for WDR1:
    WD repeat domain 1,homolog to a chick gene upregulated in the acoustically chick basilar papilla

    9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Wdr1):

    growth/sizehearing/vestibular/earhematopoietic systemhomeostasis/metabolismimmune system
    lethality-postnatallethality-prenatal/perinatalskeletonskin/coat/nails

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779 actin binding IEA--
    GO:0005515 protein binding IPI15231747
    About this table

    Pathways & Interactions
    for WDR1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    2 Interacting proteins for WDR1 (O750831 ENSP000003718903) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKIV2LQ154771EBI-351917, EBI-373226
    CORO2AENSP000003437463STRING (score=.724)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007605 sensory perception of sound TAS10036186
    About this table

    Drugs & Compounds
    for WDR1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for WDR1

    Transcripts
    for WDR1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (WDR1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005112

                  Sigma-Aldrich siRNA and siRNA Panels for WDR1  
                         Sigma-Aldrich shRNA for WDR1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005112  NM_017491  

    REFSEQ mRNAs for WDR1 gene (2 alternative transcripts): 

    NM_005112.4   NM_017491.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005112  NM_017491  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005112
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005112
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_005112 

    Additional cDNA sequence: 

    AB010427.2 AB209746.1 AF020056.1 AF020260.1 AF274954.1 AK127665.1 AK222764.1 AK222897.1 
    AK225276.1 AK291614.1 AK299602.1 AK302209.1 AK303132.1 AL050108.1 AL110208.1 AL832280.1 
    BC000201.1 BC002489.2 BC030541.2 BX648190.1 CR595687.1 CR600870.1 

    24/46 DOTS entries (see all 46 ):

    DT.101986430  DT.95282080  DT.85104817  DT.95152832  DT.95361722  DT.100846037  DT.100846013  DT.91768579 
    DT.121218406  DT.100846024  DT.100846028  DT.121218445  DT.100846029  DT.100846014  DT.121218328  DT.100846016 
    DT.121218425  DT.100846033  DT.40127487  DT.95152831  DT.100846021  DT.405263  DT.95282079  DT.95370557 

    24/806 AceView cDNA sequences (see all 806 ):

    AA617667 BM705853 CR608550 BE384026 AA962535 BI090891 BG681135 BQ652690 
    BX645584 AW276103 CN483800 BC000201 BU071167 CB152394 AA334793 BM561734 
    CK430066 BM827413 AU104493 BU631627 BE276864 CF125147 BE302242 BI222453 

    highest scoring ESTs for WDR1:

    AA116076 AI130701 AL050108 AU099189 BG724171 AA071212 AA306192 AA352129 AA375328 AB010427 

    Unigene Cluster for WDR1:

    WD repeat domain 1
    Hs.128548  [show with all ESTs]
    Unigene Representative Sequence: BX648190


    GeneLoc Exon Structure

    4 Ensembl transcripts including schematic representations:
    ENST00000264785  ENST00000400001  ENST00000382452  ENST00000382451  

    Expression
    for WDR1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    WDR1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for WDR1

    1 / 2 / 3

    10 probe-sets matching WDR1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		38736_at2, 3 U95-A 1 1.00 1.00 0.95 0.99 AL050108 0.80 1.00 0.91 1

    		61614_at2, 3 U95-C 1 0.50 1.00 0.88 1.01 AI130701 0.80 1.00 0.91 1

    		210935_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF274954 0.40 1.00 0.76 1

    		210936_at2, 3 U133-A 1 1.00 1.00 -- -- AF274954 0.40 1.00 0.76 1

    		200611_s_at2, 3 U133-A 1 1.00 1.00 -- -- AB010427 0.80 0.88 0.84 1

    		200609_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_017491 0.60 1.00 0.82 1

    		210935_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		210936_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		200611_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		200609_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.128548

    Expression variation in blood from EXPOLDB for WDR1

    Orthologs
    for WDR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for WDR1 gene from 5/21 species (see all 21 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 WDR11   -- WD repeat domain 1 89.38(n)
    96.37(a)    		 611070  XM_848702.1  XP_853795.1 
    chimpanzee
    (Pan troglodytes)    		 WDR11   -- WD repeat domain 1 99.34(n)
    99.67(a)    		 744395  XM_001158647.1  XP_001158647.1 
    cow
    (Bos taurus)    		 WDR11   -- WD repeat domain 1 89.38(n)
    95.71(a)    		 533223  NM_001046346.1  NP_001039811.1 
    rat
    (Rattus norvegicus)    		 Wdr11   -- WD repeat domain 1 88.17(n)
    95.87(a)    		 360950  NM_001014135.1  NP_001014157.1 
    mouse
    (Mus musculus)    		 Wdr11, 5 5 (24.00 cM)5
    		 WD repeat domain 11, 5 87.68(n)1
    95.21(a)1    		 223881  NM_011715.21  NP_035845.11 
     AA4089695  AF0200555  (see all 57)
    About this table        Species with no ortholog for WDR1

    ENSEMBL Gene Tree for WDR1

    Paralogs
    for WDR1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    		  --

    SNPs/Variants
    for WDR1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/325 NCBI SNPs in WDR1 are shown (see all 325 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 217)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 4 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs117315971,2
    		A,C,F,H9684583(+) TTGCAC/TATTTA 2 -- ng5111Minor allele frequency- T:0.36NA EU EA WA 974
    rs99261,2
    		A,C,F,H9685958(-) ACCCTC/TGTCTC 2 -- ut31 ese36Minor allele frequency- T:0.31MN EU EA WA 784
    rs46977061,2
    		A,C,F9728699(+) CACTTT/GTAAAA 2 -- ng314Minor allele frequency- G:0.28NA EA 362
    rs38222361,2
    		C,F,H9729059(-) CCTTAA/CCGTCC 2 -- ng314Minor allele frequency- C:0.22EU EA WA 408
    rs38222591,2
    		A,C9727843(-) AAAGGA/CACCCA 2 -- ng310--------
    rs38068161,2
    		C,F9728268(-) TTTTGC/TTTAGG 2 -- ng312Minor allele frequency- T:0.35MN EA 376
    --
    rs46979231,2
    		A,C9728542(+) TAGTTA/GCTGGC 2 -- ng310--------
    rs97321,2
    		A,F9685756(-) TCACTG/ATCTGT 2 -- ut31 ese32Minor allele frequency- A:0.50MN 372
    rs134411,2
    		C,F9708438(-) TCACAA/GTTGGC 2 I/V mis1 int1 ese311Minor allele frequency- N:0.00EA NA EU WA 2272
    --
    rs37562221,2
    		C,F9729189(-) GGAAAG/ACTTGT 2 -- ng311Minor allele frequency- A:0.40EA 1494
    About this table

    HapMap Linkage Disequilibrium images for WDR1 (up to first 250kb)

    Disorders & Mutations
    for WDR1

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 604734

    Medical News
    for WDR1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for WDR1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/30 PubMed articles for WDR1 gene (see all 30 ):

    Search for WDR1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing WDR1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 9948 HGNC: 12754 AceView: WDR1 Ensembl:ENSG00000071127 euGenes: HUgn9948
    ECgene: WDR1 H-InvDB: WDR1

    Other Databases showing WDR1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing WDR1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for WDR1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for WDR1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for WDR1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



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     Predesigned and custom siRNAs for WDR1 Antibodies for WDR1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for WDR1 Browse small molecules at Sigma-Aldrich
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