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WDR1 Gene

protein-coding   GIFtS: 59
GCID: GC04M010075

WD Repeat Domain 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 11 2     HEL-S-522
Actin-Interacting Protein 12 3     Epididymis Secretory Protein Li 522
AIP12 3     WD Repeat-Containing Protein 12
NORI-12 3     

External Ids:    HGNC: 127541   Entrez Gene: 99482   Ensembl: ENSG000000711277   OMIM: 6047345   UniProtKB: O750833   

Export aliases for WDR1 gene to outside databases

Previous GC identifers: GC04M009744 GC04M010026 GC04M009826 GC04M009752 GC04M009685 GC04M009409


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WDR1 Gene:
This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains
containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved
in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for WDR1 Gene:
WDR1 (WD repeat domain 1) is a protein-coding gene. Diseases associated with WDR1 include endocarditis, and conjunctivitis. GO annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot: WDR1_HUMAN, O75083
Function: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity)

Gene Wiki entry for WDR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_006316.17  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR1 gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   Olf-1   STAT5A   STAT1alpha   STAT2   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for WDR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

WDR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M010075:  view genomic region     (about GC identifiers)

Start:
10,075,963 bp from pter      End:
10,118,573 bp from pter
Size:
42,611 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: WDR1_HUMAN, O75083 (See protein sequence)
Recommended Name: WD repeat-containing protein 1  
Size: 606 amino acids; 66194 Da
Sequence caution: Sequence=AAD05045.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: A8K6E9 A8MPU4 O75313 Q8N6E5 Q9UG05 Q9UG78 Q9UQE0
Alternative splicing: 2 isoforms:  O75083-1   O75083-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR1: NX_O75083

Explore proteomics data for WDR1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys7, Lys28, Lys38, Lys81, Lys90, Lys95, Lys126, Lys155, Lys334, Lys362,
                                 Lys405, Lys437, Lys480, Lys484, Lys489
  • Modification sites at PhosphoSitePlus

  • See WDR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005103.2  NP_059830.1  

    ENSEMBL proteins: 
     ENSP00000427687   ENSP00000426725   ENSP00000425481   ENSP00000371890   ENSP00000371889  
    Reactome Protein details: O75083

    WDR1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for WDR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR011045 N2O_reductase_N
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry O75083

    ProtoNet protein and cluster: O75083

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: WDR1_HUMAN, O75083
    Similarity: Belongs to the WD repeat AIP1 family
    Similarity: Contains 11 WD repeats


    WDR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR1_HUMAN, O75083
    Function: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity)

         Genatlas biochemistry entry for WDR1:
    WD repeat domain 1,homolog to a chick gene upregulated in the acoustically chick basilar papilla

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
         
    WDR1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for WDR1:
     Decreased cilium length  Decreased cilium length after  

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Wdr1):
     cellular  growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  skeleton 

    WDR1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDR1
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    miRNA
    Products:
        
    miRTarBase miRNAs that target WDR1:
    hsa-mir-1226-3p (MIRT036411), hsa-mir-375 (MIRT019985), hsa-mir-877-3p (MIRT036948), hsa-mir-615-3p (MIRT039865), hsa-mir-92a-3p (MIRT049572), hsa-mir-93-5p (MIRT028095)

    Block miRNA regulation of human, mouse, rat WDR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WDR1 (see all 48):
    hsa-miR-301a hsa-miR-30d hsa-miR-519a hsa-miR-218 hsa-miR-30a hsa-miR-520g hsa-miR-518c hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidWDR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WDR1
    Predesigned siRNA for gene silencing in human, mouse, rat WDR1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): WDR1 (NM_017491)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WDR1_HUMAN, O75083: Cytoplasm, cytoskeleton (By similarity). Cell projection, podosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    extracellular4
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002102podosome IEA--
    GO:0005576extracellular region TAS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0030054cell junction IEA--

    WDR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WDR1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    2Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    3Hypertrophy Model
    Hypertrophy Model

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WDR1
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    PTEN Pathway
    Epithelial Adherens Junctions

    1 BioSystems Pathway for WDR1
        Hypertrophy Model

    1 Reactome Pathway for WDR1
        Platelet degranulation



    WDR1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR1
    Interactions:

        Search GeneGlobe Interaction Network for WDR1

    Selected Interacting proteins for WDR1 (O750832, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253792 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253792 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253792 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253792 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253792 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0007596blood coagulation TAS--
    GO:0007605sensory perception of sound TAS10036186
    GO:0030168platelet activation TAS--

    WDR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WDR1 gene (2 alternative transcripts): 
    NM_005112.4  NM_017491.3  

    Unigene Cluster for WDR1:

    WD repeat domain 1
    Hs.128548  [show with all ESTs]
    Unigene Representative Sequence: BX648190
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000499869 ENST00000515743(uc010idm.3 uc003gmh.2) ENST00000502702
    ENST00000502962(uc021xly.1) ENST00000506246 ENST00000504739 ENST00000508949
    ENST00000505543 ENST00000510848 ENST00000509695 ENST00000508079 ENST00000264785
    ENST00000505851 ENST00000514319 ENST00000515018 ENST00000509600 ENST00000382452(uc021xlv.1)
    ENST00000382451(uc021xlw.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate WDR1 (see all 48):
    hsa-miR-301a hsa-miR-30d hsa-miR-519a hsa-miR-218 hsa-miR-30a hsa-miR-520g hsa-miR-518c hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidWDR1 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR1
    Primer
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    OriGene qPCR primer pairs and template standards for WDR1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR1
      QuantiTect SYBR Green Assays in human, mouse, rat WDR1
      QuantiFast Probe-based Assays in human, mouse, rat WDR1

    Additional mRNA sequence: 

    AB010427.2 AB209746.1 AF020056.1 AF020260.1 AF274954.1 AK127665.1 AK222764.1 AK222897.1 
    AK225276.1 AK291614.1 AK299602.1 AK302209.1 AK303132.1 AL050108.1 AL110208.1 AL832280.1 
    BC000201.1 BC002489.2 BC030541.2 BX648190.1 HQ013239.1 

    Selected DOTS entries (see all 44):

    DT.101986430  DT.95282080  DT.85104817  DT.95152832  DT.95361722  DT.100846037  DT.100846013  DT.121218406 
    DT.91768579  DT.100846024  DT.100846028  DT.121218445  DT.100846029  DT.100846014  DT.121218328  DT.100846016 
    DT.121218425  DT.100846033  DT.40127487  DT.95152831  DT.100846021  DT.405263  DT.95282079  DT.100846036 

    Selected AceView cDNA sequences (see all 806):

    BM561734 BM827413 BQ652529 BQ934474 AI796213 AL050108 AA314850 BI090891 
    CB121996 T34803 BI334275 BM705853 BG681135 Z40083 CF125147 AA044998 
    BQ231580 CK430066 BQ772816 AA364935 BU071167 CA426181 T93118 CB153441 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR1 expression in normal human tissues (normalized intensities)      WDR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    WDR1 Expression
    About this image


    WDR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    WDR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.128548
        Custom PCR Arrays for WDR1
    Primer
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    OriGene qPCR primer pairs and template standards for WDR1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR1
    QuantiTect SYBR Green Assays in human, mouse, rat WDR1
    QuantiFast Probe-based Assays in human, mouse, rat WDR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDR1 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr11 , 5 WD repeat domain 11, 5 87.68(n)1
    95.21(a)1
      5 (20.63 cM)5
    223881  NM_011715.21  NP_035845.11 
     385268135 
    chicken
    (Gallus gallus)
    Aves WDR11 WD repeat domain 1 77.17(n)
    88.61(a)
      422842  NM_001004402.1  NP_001004402.1 
    lizard
    (Anolis carolinensis)
    Reptilia WDR16
    WD repeat domain 1
    81(a)
    1 ↔ 1
    GL343236.1(282176-319698)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041232.12   -- 74.95(n)    BC041232.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045455.12   -- 76.67(n)   394014  BC045455.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG107243
    flr1
    actin polymerization and/or
    depolymerization actin more3
    flare1
    50(a)3
    56.51(n)1
    48.99(a)1
      395051  NM_140385.41  NP_648642.11 
    worm
    (Caenorhabditis elegans)
    Secernentea K08F9.23
    aipl-11
    beta-transducin like protein3
    aipl-11
    42(a)
    (best of 2)3
    48.71(n)1
    42.71(a)1
      V(15136910-15139395)3
    1800221  NM_074332.41  NP_506733.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AIP1(YMR092C)4
    AIP11
    Actin cortical patch component, interacts with the more4
    AIP11
    43.97(n)1
    32.63(a)1
      13(453479-451632)4
    8551171, 4  NP_013810.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G180601 AT3G18060 48.96(n)
    38.79(a)
      821331  NM_112688.5  NP_188434.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g01258001 Os01g0125800 47.34(n)
    37.48(a)
      4326007  NM_001048428.1  NP_001041893.1 


    ENSEMBL Gene Tree for WDR1 (if available)
    TreeFam Gene Tree for WDR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR1 (see all 1404)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs117315971,2
    C,F,A,H--10025427(+) TTGCAC/TATTTA 2 -- ds500131Minor allele frequency- T:0.33NA NS EA WA CSA 2916
    rs1505894331,2
    --10025434(+) TTTAGA/GCAACT 2 -- ds50010--------
    rs1394413631,2
    --10025533(+) TTAACA/GTCTAA 2 -- ds50010--------
    rs743424741,2
    C,F--10025590(+) TGAGAA/GGTAGA 2 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1852088601,2
    --10025770(+) TCTGAC/TAATCC 2 -- ds50010--------
    rs1431547071,2
    --10025864(+) CCAGCC/TGCCCC 2 -- ds50010--------
    rs576915231,2
    C,F--10025875(+) ACACAC/ACCCCA 2 -- ds50013Minor allele frequency- A:0.06WA CSA 122
    rs1466738651,2
    --10026059(+) ACTTAC/GTTTTA 2 -- ut310--------
    rs31727241,2
    C--10026120(-) AAGTCA/CCTGTA 2 -- ut31 ese32Minor allele frequency- C:0.01MN NA 186
    rs1881286781,2
    --10026230(+) GTCTGA/GCTAAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for WDR1 (10075963 - 10118573 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for WDR1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv989430CNV Deletion20482838
    nsv525589CNV Loss19592680
    nsv469621CNV Loss16826518
    nsv829857CNV Gain17160897
    nsv878692CNV Gain21882294
    dgv5476n71CNV Gain21882294
    nsv524687CNV Gain19592680
    esv2752052CNV Gain17911159
    nsv428438CNV Gain18775914
    esv24360CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 604734    OMIM disorders: --

    7 diseases for WDR1:    About MalaCards
    endocarditis    conjunctivitis    down syndrome    multiple sclerosis
    schizophrenia    malaria    endotheliitis


    WDR1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WDR1

    Export disorders for WDR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR1 gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with WDR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein. (PubMed id 10036186)1, 2, 3 Adler H.J.... Lomax M.I. (Genomics 1999)
    2. A genome-wide association study of serum uric acid in African Americans. (PubMed id 21294900)1, 4 Charles B.A....Rotimi C.N. (BMC Med Genomics 2011)
    3. Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. (PubMed id 18179892)1, 4 Wallace C....Munroe P.B. (Am. J. Hum. Genet. 2008)
    4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    7. Critical roles of actin-interacting protein 1 in cytokinesis and chemotactic migration of mammalian cells. (PubMed id 18494608)1, 9 Kato A....Mizuno K. (Biochem. J. 2008)
    8. Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. (PubMed id 17293856)1, 9 Li J....Yuan J. (Nat. Cell Biol. 2007)
    9. AIP1/WDR1 supports mitotic cell rounding. (PubMed id 15629458)1, 9 Fujibuchi T....Kito K. (Biochem. Biophys. Res. Commun. 2005)
    10. OTUB1 modulates c-IAP1 stability to regulate signalling pathways. (PubMed id 23524849)1 Goncharov T....Vucic D. (EMBO J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9948 HGNC: 12754 AceView: WDR1 Ensembl:ENSG00000071127 euGenes: HUgn9948
    ECgene: WDR1 H-InvDB: WDR1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for WDR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for WDR1 gene:
    Search GeneIP for patents involving WDR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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