Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDPCP Gene

protein-coding   GIFtS: 44
GCID: GC02M063349

WD repeat containing planar cell polarity effector

(Previous name: chromosome 2 open reading frame 86 )
(Previous symbol: C2orf86)
 Explore 5 diseases affiliated with
WDPCP via our new
 Human Malady Compendium 
Biological research products
for WDPCP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
WD Repeat Containing Planar Cell Polarity Effector1 2     HFrtz1
BBS151 2 3 5     FRTZ2
C2orf861 2 3 5     WD Repeat-Containing And Planar Cell Polarity Effector Protein Fritz Homolog2
FRITZ2 3     WD Repeat-Containing Protein C2orf862
Bardet-Biedl Syndrome 15 Protein2 3     HFRTZ1
Chromosome 2 Open Reading Frame 861     WD Repeat-Containing And Planar Cell Polarity Effector Protein3
Fritz1     

External Ids:    HGNC: 280271   Entrez Gene: 510572   Ensembl: ENSG000001439517   OMIM: 6135805   UniProtKB: O958763   

Export aliases for WDPCP gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WDPCP:
This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein
that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in
this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. (provided
by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: FRITZ_HUMAN, O95876
Function: Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in
both ciliogenesis and collective cell movements (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for WDPCP
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for WDPCP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDPCP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p15   Ensembl cytogenetic band:  2p15   HGNC cytogenetic band: 2p15

WDPCP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDPCP gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M063349:  view genomic region     (about GC identifiers)

Start:
63,348,518 bp from pter      End:
64,054,977 bp from pter
Size:
706,460 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FRITZ_HUMAN, O95876 (See protein sequence)
Recommended Name: WD repeat-containing and planar cell polarity effector protein fritz homolog  
Size: 746 amino acids; 85084 Da
Subcellular location: Cell membrane (By similarity). Cytoplasm, cytoskeleton, cilium axoneme (By similarity)
Caution: It is uncertain whether Met-1 or Met-34 is the initiator
Secondary accessions: Q53RW4 Q7Z2Z3
Alternative splicing: 3 isoforms:  O95876-1   O95876-2   O95876-3   

Explore the universe of human proteins at neXtProt for WDPCP: NX_O95876

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95876

  • WDPCP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056994.3  
    ENSEMBL proteins: 
     ENSP00000386795   ENSP00000272321   ENSP00000386592   ENSP00000386769   ENSP00000381552  
     ENSP00000387222   ENSP00000411429   ENSP00000430288   ENSP00000409982   ENSP00000396226  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: WDPCP
    OriGene Custom Protein Services for WDPCP 
    GenScript Custom Purified and Recombinant Proteins Services for WDPCP
    Novus Biologicals WDPCP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for WDPCP

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005856cytoskeleton IEA--
    GO:0005886colocalizes with plasma membrane ISS--
    GO:0005938colocalizes with cell cortex ISS--
    GO:0016324colocalizes with apical plasma membrane ISS--
    GO:0035085cilium axoneme ISS--


    WDPCP for ontologies           About GeneDecksing



    WDPCP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for WDPCP 
    GenScript Custom Superior Antibodies Services for WDPCP
    Novus Biologicals WDPCP Antibodies
    Search for Antibodies for WDPCP at Abcam  
    Uscn Antibodies for WDPCP
    ThermoFisher Antibodies for WDPCP

    Assay Products for WDPCP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WDPCP
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for WDPCP


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    WDPCP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR024511 DUF3312

    Graphical View of Domain Structure for InterPro Entry O95876

    ProtoNet protein and cluster: O95876

    UniProtKB/Swiss-Prot: FRITZ_HUMAN, O95876
    Similarity: Belongs to the WD repeat fritz family
    Similarity: Contains 2 WD repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: FRITZ_HUMAN, O95876
    Function: Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in
    both ciliogenesis and collective cell movements (By similarity)

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: WDPCP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WDPCP
    1 QIAGEN miScript miRNA Assays for microRNA that regulate WDPCP:
    hsa-miR-323-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDPCP (see all 7)
    OriGene shRNA RFP: WDPCP
    OriGene siRNA: WDPCP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDPCP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WDPCP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDPCP (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDPCP (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: WDPCP (NM_015910)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDPCP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDPCP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for WDPCP
    Search LifeMap BioReagents cell lines for WDPCP

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDPCP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDPCP

    1 Interacting protein for WDPCP (O958763) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RCHY1Q96PM53I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016476regulation of embryonic cell shape ISS--
    GO:0032185septin cytoskeleton organization ISS--
    GO:0032880regulation of protein localization ISS--
    GO:0060271cilium morphogenesis ISS--


    WDPCP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDPCP
    Search CenterWatch for drugs/clinical trials and news about WDPCP / FRITZ 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WDPCP gene (2 alternative transcripts): 
    NM_015910.5  NM_001042692.1  

    Unigene Cluster for WDPCP:

    WD repeat containing planar cell polarity effector
    Hs.414952  [show with all ESTs]
    Unigene Representative Sequence: BX647132
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409354 ENST00000272321(uc002sce.3 uc002scf.3 uc010ypu.2 uc002sch.3)
    ENST00000409199 ENST00000487280 ENST00000409120(uc002scg.3) ENST00000398544
    ENST00000409562 ENST00000409835 ENST00000417238(uc002sci.2) ENST00000462652
    ENST00000493315(uc010fcr.1) ENST00000473678 ENST00000418148 ENST00000490935
    ENST00000431065 ENST00000467687 ENST00000484073

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: WDPCP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WDPCP
    1 QIAGEN miScript miRNA Assays for microRNA that regulate WDPCP:
    hsa-miR-323-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDPCP (see all 7)
    OriGene shRNA RFP: WDPCP
    OriGene siRNA: WDPCP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDPCP
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDPCP (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDPCP (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: WDPCP (NM_015910)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDPCP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDPCP 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDPCP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDPCP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDPCP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDPCP

    Additional cDNA sequence: 

    AF131737.1 AK001849.1 AK022647.1 AK055030.1 AK309028.1 AK310290.1 AL833623.1 BC093752.1 
    BC093754.1 BC143426.1 BX538331.1 BX647132.1 

    13 DOTS entries:

    DT.308953  DT.91720641  DT.95248434  DT.95366272  DT.40222722  DT.97838476  DT.100754390  DT.101981220 
    DT.91941635  DT.95366275  DT.100731062  DT.121010411  DT.121010510 

    24/61 AceView cDNA sequences (see all 61):

    CB153284 AI279372 BG575480 BE888656 NM_015910 AL833623 AF131737 BG198790 
    AK022647 BF111261 BG184304 BX538331 BG479284 AU135376 AW078538 BX472012 
    AI698205 AI458350 BI086427 BE883073 BX478657 BG191632 AW195576 BG207113 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDPCP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTGTGAAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    WDPCP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainChoroid PlexusBrain
    BrainMedulla OblongataBrain
    BrainMidbrain tegmentumBrain
    Neural TubeDiencephalic Roof PlateNeural Tube
    Neural TubeMesencephalic Floor PlateNeural Tube
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See WDPCP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDPCP

    SOURCE GeneReport for Unigene cluster: Hs.414952
        SABiosciences Custom PCR Arrays for WDPCP
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDPCP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDPCP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDPCP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDPCP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDPCP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WDPCP gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdpcp1 , 5 WD repeat containing planar cell polarity effector1, 5 83.47(n)1
    79.78(a)1
      11 (13.90 cM)5
    2165601  NM_145425.31  NP_663400.21 
     215722355 
    chicken
    (Gallus gallus)
    Aves WDPCP1 WD repeat containing planar cell polarity effector 77.34(n)
    74.67(a)
      428553  XM_426108.3  XP_426108.3 
    lizard
    (Anolis carolinensis)
    Reptilia WDPCP6
    --
    67(a)
    1 ↔ 1
    1(120701995-120754276)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.142302 Transcribed sequence with weak similarity to protein refNP_056994.1 (H.sapiens) hypothetical protein LOC51057 [Homo sapiens] less 76.86(n)    137716954 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003331251 WD repeat-containing protein C2orf86-like 56.74(n)
    50.25(a)
      100333125  XM_002665191.1  XP_002665237.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta frtz1 fritz 41.41(n)
    30.31(a)
      33349  NM_134770.1  NP_608614.1 


    ENSEMBL Gene Tree for WDPCP (if available)
    TreeFam Gene Tree for WDPCP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6491 NCBI SNPs in WDPCP are shown (see all 6491    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs573158281,2
    C,--63087375(+) TAATAA/CATACT 1 -- ds50013Minor allele frequency- C:0.05WA CSA 121
    rs558076171,2
    C,F,--63087876(+) ACGATC/TACTTT 1 -- ut313Minor allele frequency- T:0.02WA EU 705
    rs10447971,2
    H--63088040(-) TTCTTC/TATATC 1 -- ut31 ese36Minor allele frequency- T:0.00MN NS EA NA 606
    rs758304441,2
    --63090175(+) TTTTTC/TTGTTT 1 -- int11Minor allele frequency- T:0.50NA 2
    rs2006314631,2
    C--63090177(-) ACAAAA/CAGAAA 1 -- int10--------
    rs1159537751,2
    C,F,--63091095(+) TTTTCT/CGAGTA 1 -- int11Minor allele frequency- C:0.02NA 120
    rs134028301,2
    C,--63092013(+) tttttG/Tttttg 1 -- int1 trp30--------
    rs792298861,2
    F,--63092505(+) GATGAA/CGAAAC 1 -- int11Minor allele frequency- C:0.08NA 120
    rs728116021,2
    C,--63092684(+) TGTATA/GAAACA 1 -- int10--------
    rs101843641,2
    C,--63092741(+) tttttG/Tttttt 1 -- int1 trp30--------

    HapMap Linkage Disequilibrium report for WDPCP (63348518 - 63598518 bp, first 250kb of WDPCP)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for WDPCP: --
    Human Gene Mutation Database (HGMD): WDPCP

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDPCP
    DNA2.0 Custom Variant and Variant Library Synthesis for WDPCP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    WDPCP for disorders           About GeneDecksing

    OMIM gene information: 613580   
    OMIM disorders: 209900  
    UniProtKB/Swiss-Prot: FRITZ_HUMAN, O95876
  • Defects in WDPCP are the cause of Bardet-Biedl syndrome type 15 (BBS15) [MIM:209900]. Bardet-Biedl syndrome
  • (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary
    retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary
    features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is
    autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for
    clinical manifestation of some forms of the disease
  • Note=Mutations in WDPCP may act as modifiers of the phenotypic expression of Bardet-Biedl syndrome and Meckel
  • syndrome by interacting in trans with primary BBS and MKS loci

    5 diseases for WDPCP:    About MalaCards
    bardet-biedl syndrome 15    bardet-biedl syndrome    pigmentary retinopathy    meckel syndrome
    polydactyly


    Export disorders for WDPCP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDPCP gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with WDPCP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Planar cell polarity acts through septins to control collective cell movement and ciliogenesis. (PubMed id 20671153)1, 2 Kim S.K....Wallingford J.B. (2010)
    2. The WD40 repeat protein fritz links cytoskeletal planar polarity to frizzled subcellular localization in the Drosophila epidermis. (PubMed id 15654087)1, 3 Collier S....Adler P. (2005)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    4. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    5. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1 Melzer D....Ferrucci L. (2008)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51057 HGNC: 28027 AceView: LOC51057 Ensembl:ENSG00000143951 euGenes: HUgn51057
    ECgene: WDPCP H-InvDB: WDPCP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDPCP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WDPCP gene:
    Search GeneIP for patents involving WDPCP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for WDPCP  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDPCP   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDPCP  
     OriGene Protein Over-expression Lysate for WDPCP   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for WDPCP   OriGene 3'-UTR Clone for WDPCP  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDPCP   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDPCP  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for WDPCP   OriGene Custom Protein Services for WDPCP  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDPCP
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDPCP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDPCP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDPCP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDPCP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDPCP
     GenScript Custom Purified and Recombinant Proteins Services for WDPCP GenScript cDNA clones with any tag delivered in your preferred vector for WDPCP
     GenScript Custom Assay Services for WDPCP GenScript Custom Superior Antibodies Services for WDPCP
     GenScript Custom overexpressing Cell Line Services for WDPCP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for WDPCP
     Search Chromatin IP Primers for WDPCP
     RT2 qPCR Primer Assay in human, mouse, rat WDPCP
     Search GNC Networks for WDPCP
     SABiosciences Custom PCR Arrays for WDPCP
     Search Tocris compounds for WDPCP
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     WDPCP antibodies
     WDPCP lysates
     Search for Antibodies for WDPCP at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for WDPCP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     WDPCP Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for WDPCP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDPCP
     Browse SwitchGear 3'UTR luciferase reporter plasmids for WDPCP
     Browse SwitchGear Promoter luciferase reporter plasmids for WDPCP
     ThermoFisher Antibodies for WDPCP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDPCP
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      WDPCP gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4