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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDHD1 Gene

protein-coding   GIFtS: 50
GCID: GC14M055405

WD Repeat And HMG-Box DNA Binding Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WD Repeat And HMG-Box DNA Binding Protein 11 2     CHTF42
CTF41 2     CTF4, Chromosome Transmission Fidelity Factor 4 Homolog2
Acidic Nucleoplasmic DNA-Binding Protein 12 3     WD Repeat And HMG-Box DNA-Binding Protein 12
Chromosome Transmission Fidelity Factor 4 Homolog (S. Cerevisiae)1     AND13
AND-12     And-13

External Ids:    HGNC: 231701   Entrez Gene: 111692   Ensembl: ENSG000001985547   OMIM: 6081265   UniProtKB: O757173   

Export aliases for WDHD1 gene to outside databases

Previous GC identifers: GC14M053397 GC14M053372 GC14M054477 GC14M035568


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WDHD1 Gene:
The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group
(HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory
modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many
eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results
in two transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for WDHD1 Gene: 
WDHD1 (WD repeat and HMG-box DNA binding protein 1) is a protein-coding gene. Diseases associated with WDHD1 include trench fever, and syringomyelia. GO annotations related to this gene include RNA polymerase binding and RNA binding.

UniProtKB/Swiss-Prot: WDHD1_HUMAN, O75717
Function: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase
alpha/primase complex in order to initiate DNA replication




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDHD1 gene promoter:
         HSF1 (long)   E47   AREB6   CREB   FOXJ2 (long isoform)   deltaCREB   SEF-1 (1)   HSF1short   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDHD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for WDHD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDHD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.2   Ensembl cytogenetic band:  14q22.2   HGNC cytogenetic band: 14q22.2

WDHD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDHD1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M055405:  view genomic region     (about GC identifiers)

Start:
55,405,656 bp from pter      End:
55,493,823 bp from pter
Size:
88,168 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WDHD1_HUMAN, O75717 (See protein sequence)
Recommended Name: WD repeat and HMG-box DNA-binding protein 1  
Size: 1129 amino acids; 125967 Da
Subunit: Interacts with the polymerase alpha catalytic subunit POLA1. Interacts with MCM10. Interacts with DNA2
Subcellular location: Nucleus, nucleoplasm (By similarity)
1 PDB 3D structure from and Proteopedia for WDHD1:
2D7L (3D)    

Explore the universe of human proteins at neXtProt for WDHD1: NX_O75717

Explore proteomics data for WDHD1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75717

  • WDHD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WDHD1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001008397.1  NP_009017.1  

    ENSEMBL proteins: 
     ENSP00000353793   ENSP00000399349   ENSP00000456806   ENSP00000413435   ENSP00000391049  
     ENSP00000352085  

    Human Recombinant Protein Products for WDHD1: 
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    Novus Biologicals WDHD1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WDHD1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm TAS9175701

    WDHD1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    5/7 InterPro protein domains (see all 7):
     IPR013979 TIF_beta_prop-like
     IPR019775 WD40_repeat_CS
     IPR009071 HMG_box_dom
     IPR001680 WD40_repeat
     IPR022100 DUF3639

    Graphical View of Domain Structure for InterPro Entry O75717

    ProtoNet protein and cluster: O75717

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: WDHD1_HUMAN, O75717
    Similarity: Contains 1 HMG box DNA-binding domain
    Similarity: Contains 7 WD repeats


    WDHD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDHD1_HUMAN, O75717
    Function: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase
    alpha/primase complex in order to initiate DNA replication

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0070063RNA polymerase binding IEA--
         
    WDHD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WDHD1:
     Increased G2M DNA content 

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WDHD1 
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    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate WDHD1 (see all 9):
    hsa-miR-505 hsa-miR-3618 hsa-miR-3140-3p hsa-miR-561 hsa-miR-513a-3p hsa-miR-340 hsa-miR-1305 hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmidWDHD1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDHD1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WDHD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for WDHD1 (O757171, 3 ENSP000003537934) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KAT2AQ928301, 3, ENSP000002259164EBI-3951691,EBI-477622 I2D: score=1 STRING: ENSP00000225916
    NCOA2Q155963, ENSP000003999684I2D: score=1 STRING: ENSP00000399968
    SRCP129313, ENSP000003509414I2D: score=1 STRING: ENSP00000350941
    GBASO753233I2D: score=1 
    HIST2H3CENSP000003581544STRING: ENSP00000358154
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing IEA--
    GO:0033044regulation of chromosome organization IEA--
    GO:0070829heterochromatin maintenance IEA--

    WDHD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDHD1

    Search CenterWatch for drugs/clinical trials and news about WDHD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WDHD1 gene (2 alternative transcripts): 
    NM_001008396.2  NM_007086.3  

    Unigene Cluster for WDHD1:

    WD repeat and HMG-box DNA binding protein 1
    Hs.385998  [show with all ESTs]
    Unigene Representative Sequence: NM_007086
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360586(uc010aom.2 uc001xbm.2 uc001xbn.2) ENST00000420358
    ENST00000567693 ENST00000475379 ENST00000455555 ENST00000421192 ENST00000359167

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WDHD1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate WDHD1 (see all 9):
    hsa-miR-505 hsa-miR-3618 hsa-miR-3140-3p hsa-miR-561 hsa-miR-513a-3p hsa-miR-340 hsa-miR-1305 hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmidWDHD1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Sirion Biotech Customized lentivirus for stable overexpression of WDHD1 
                         Customized lentivirus expression plasmids for stable overexpression of WDHD1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for WDHD1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDHD1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDHD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDHD1

    Additional mRNA sequence: 

    AJ006266.1 AK001538.1 AK001585.1 AK001620.1 AK293005.1 AY517556.1 BC000622.2 BC005040.1 
    BC043349.1 BC063041.1 

    12 DOTS entries:

    DT.107598  DT.97817273  DT.120786586  DT.101980015  DT.86857255  DT.97793240  DT.100023279  DT.440168 
    DT.95365607  DT.95365608  DT.99931138  DT.118516 

    24/112 AceView cDNA sequences (see all 112):

    BC063041 CF529821 AI203233 AA315413 CB122476 BQ435406 BM978997 BQ012014 
    BU509101 BC043349 AW500820 BQ439066 AW613020 BE274400 AK001538 AI339309 
    BC000622 BC005040 AI126514 AA732499 AL709945 BE046969 AI275133 AA738256 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDHD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTGTGT
    WDHD1 Expression
    About this image


    See WDHD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDHD1

    SOURCE GeneReport for Unigene cluster: Hs.385998
        SABiosciences Custom PCR Arrays for WDHD1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDHD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDHD1 gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdhd11 , 5 WD repeat and HMG-box DNA binding protein 11, 5 85(n)1
    83.89(a)1
      14 (24.60 cM)5
    2189731  NM_172598.31  NP_766186.21 
     472409445 
    chicken
    (Gallus gallus)
    Aves WDHD11 WD repeat and HMG-box DNA binding protein 1 73.52(n)
    72.6(a)
      423558  XM_421449.3  XP_421449.3 
    lizard
    (Anolis carolinensis)
    Reptilia WDHD16
    WD repeat and HMG-box DNA binding protein 1
    67(a)
    1 ↔ 1
    GL343325.1(27075-60412)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978702 AND-1 protein 74.74(n)    X98884.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa11f102 wufa11f10 75.58(n)   335004  BQ263863.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ctf41 CG13350-PA 44.01(n)
    33.92(a)
      36551  NM_137077.3  NP_610921.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_F17C11.101 Protein F17C11.10 43.46(n)
    27.96(a)
      179521  NM_073398.2  NP_505799.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CTF4(YPR135W)4
    CTF41
    Chromatin-associated protein, required for sister chromatid more4
    Ctf4p1
    40.41(n)1
    25.23(a)1
      16(799234-802017)4
    8562541, 4  NP_015461.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G426601 chromosome transmission fidelity protein 4 43.21(n)
    28.36(a)
      823286  NM_114133.2  NP_189852.2 
    rice
    (Oryza sativa)
    Liliopsida Os09g02411001 hypothetical protein 44.9(n)
    32.73(a)
      4346476  NM_001069180.1  NP_001062645.1 


    ENSEMBL Gene Tree for WDHD1 (if available)
    TreeFam Gene Tree for WDHD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WDHD1 gene

    WDHD1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for WDHD1
    PGOHUM00000248176


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2017 SNPs in WDHD1 are shown (see all 2017)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1137777551,2
    C--55405222(+) ACTCCA/GGCCTG 2 -- ds50012Minor allele frequency- G:0.05CSA NA 122
    rs1864561281,2
    --55405268(+) GGAGTA/TTGAGA 2 -- ds50010--------
    rs1113944141,2
    C--55405291(+) ACATGA/GTGAAA 2 -- ds50013Minor allele frequency- G:0.12CSA WA NA 240
    rs1174015581,2
    C,F--55405292(+) CATGAT/CGAAAC 2 -- ds50011Minor allele frequency- C:0.01EA 120
    rs727155571,2
    C--55405392(+) CTCAGC/TCCAGG 2 -- ds50010--------
    rs1163831811,2
    C,F--55405427(+) GACTGT/AGCCAC 2 -- ds50011Minor allele frequency- A:0.22WA 118
    rs1485281201,2
    --55405428(+) ACTGTA/GCCACT 2 -- ds50010--------
    rs1396695471,2
    C--55405472(+) CTTTA-/AAAT  
            
    AAATA
    2 -- ds50010--------
    rs1999608281,2
    --55405497(+) TAAAT-/AAATA 
            
    AAAGT
    2 -- ds50010--------
    rs1428954851,2
    --55405533(+) ACAATA/GCATGA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for WDHD1 (55405656 - 55493823 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for WDHD1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing WDHD1
    DNA2.0 Custom Variant and Variant Library Synthesis for WDHD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608126    OMIM disorders: --

    7 diseases for WDHD1:    About MalaCards
    trench fever    syringomyelia    agoraphobia    yellow fever
    meningioma    esophagitis    leukemia

    1 disease from the University of Copenhagen DISEASES database for WDHD1:
    Trench fever

    WDHD1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WDHD1
    Human Genome Epidemiology (HuGE) Navigator: WDHD1 (5 documents)

    Export disorders for WDHD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDHD1 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with WDHD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of WD repeat and high-mobility group box D NA binding protein 1 in pulmonary and esophageal carcinogenesis. (PubMed id 20028748)1, 3 Sato N....Daigo Y. (2010)
    2. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    5. Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. (PubMed id 19805216)1, 2 Im J.S.... Lee J.K. (2009)
    6. Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. (PubMed id 17761813)1, 2 Zhu W....Dutta A. (2007)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. AND-1, a natural chimeric DNA-binding protein, combines an HMG-box with regulatory WD-repeats. (PubMed id 9175701)1, 3 Kohler A....Franke W.W. (1997)
    10. Acidic nucleoplasmic DNA-binding protein (And-1) contr ols chromosome congression by regulating the assembly of centromere protein A (C ENP-A) at centromeres. (PubMed id 23184928)1 Jaramillo-Lambert A....Zhu W. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11169 HGNC: 23170 AceView: WDHD1 Ensembl:ENSG00000198554 euGenes: HUgn11169
    ECgene: WDHD1 H-InvDB: WDHD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDHD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WDHD1 gene:
    Search GeneIP for patents involving WDHD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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