WDHD1 Gene
protein-coding GIFtS: 48
GCID: GC14M055405
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|
WD repeat and HMG-box DNA binding protein 1
| |
Aliases
for WDHD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat And HMG-Box DNA Binding Protein 11 2 | | CTF4, Chromosome Transmission Fidelity Factor 4 Homolog2 | | AND-11 2 | | WD Repeat And HMG-Box DNA-Binding Protein 12 | | CHTF41 2 | | AND13 | | CTF41 2 | | And-13 | | Acidic Nucleoplasmic DNA-Binding Protein 12 3 | | |
Export aliases for WDHD1 gene to outside databasesPrevious GC identifers: GC14M053397 GC14M053372 GC14M054477 GC14M035568 |
Summaries
for WDHD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WDHD1:
The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG)box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules insignal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteinsinvolved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variantsencoding different isoforms. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: WDHD1_HUMAN, O75717Function: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerasealpha/primase complex in order to initiate DNA replication
|
Genomic Views
for WDHD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDHD1 gene promoter:
HSF1 (long) E47 AREB6 CREB FOXJ2 (long isoform) deltaCREB SEF-1 (1) HSF1short Hand1
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDHD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDHD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q22.2 Ensembl cytogenetic band: 14q22.2 HGNC cytogenetic band: 14q22.2WDHD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M055405: view genomic region
(about GC identifiers)
Start:
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55,405,656 bp from pter |
End:
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55,493,823 bp from pter |
Size:
|
88,168 bases |
Orientation:
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minus strand |
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Proteins
for WDHD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDHD1_HUMAN, O75717 (See
protein sequence)Recommended Name: WD repeat and HMG-box DNA-binding protein 1 Size: 1129 amino acids; 125967 Da
Subunit: Interacts with the polymerase alpha catalytic subunit POLA1. Interacts with MCM10. Interacts with DNA2
Subcellular location: Nucleus, nucleoplasm (By similarity)
1 PDB 3D structure from  and Proteopedia  for WDHD1:2D7L (3D)
Explore the universe of human proteins at neXtProt for WDHD1: NX_O75717
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75717
WDHD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001008397.1 NP_009017.1
ENSEMBL proteins: ENSP00000353793 ENSP00000399349 ENSP00000456806 ENSP00000413435 ENSP00000391049 ENSP00000352085
Human Recombinant Protein Products for WDHD1:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
WDHD1 for ontologies About GeneDecksing
WDHD1 Antibody Products:
Assay Products for WDHD1: |
Protein
Domains /
Families
for WDHD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDHD1 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry O75717ProtoNet protein and cluster: O75717 1 Blocks protein family: IPB001680 G-protein beta WD-40 repeat signature
UniProtKB/Swiss-Prot: WDHD1_HUMAN, O75717Similarity: Contains 1 HMG box DNA-binding domainSimilarity: Contains 7 WD repeats |
Function
for WDHD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: WDHD1_HUMAN, O75717Function: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerasealpha/primase complex in order to initiate DNA replication Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
WDHD1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for WDHD1:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDHD1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): WDHD1 (NM_007086) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDHD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDHD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDHD1 |
|
Pathways & Interactions
for WDHD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WDHD1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/8 Interacting proteins for WDHD1 (O757171, 3 ENSP000003537934) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006396 | RNA processing |
IEA | -- | | GO:0033044 | regulation of chromosome organization |
IEA | -- | | GO:0070829 | heterochromatin maintenance |
IEA | -- |
WDHD1 for ontologies About GeneDecksing
|
Drugs & Compounds
for WDHD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDHD1
Search CenterWatch for drugs/clinical trials and news about WDHD1
|
Transcripts
for WDHD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDHD1 gene (2 alternative transcripts): NM_001008396.2 NM_007086.3 Unigene Cluster for WDHD1: WD repeat and HMG-box DNA binding protein 1 Hs.385998 [show with all ESTs]Unigene Representative Sequence: NM_0070867 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000360586(uc010aom.2 uc001xbm.2 uc001xbn.2) ENST00000420358
ENST00000567693 ENST00000475379 ENST00000455555 ENST00000421192 ENST00000359167
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDHD1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDHD1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): WDHD1 (NM_007086) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDHD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDHD1 |
Additional cDNA sequence: AJ006266.1 AK001538.1 AK001585.1 AK001620.1 AK293005.1 AY517556.1 BC000622.2 BC005040.1 BC043349.1 BC063041.1 12 DOTS entries: DT.107598 DT.97817273 DT.120786586 DT.101980015 DT.86857255 DT.97793240 DT.100023279 DT.440168 DT.95365607 DT.95365608 DT.99931138 DT.118516 24/112 AceView cDNA sequences (see all 112): BM978997 AI126514 BQ435406 AK001538 AA315413 BQ439066 BC000622 BE274400 BU509101 AW613020 BE046969 CF529821 AL709945 AI339309 AI275133 CB122476 AI203233 BQ012014 AA732499 AW500820 BC063041 BC005040 BC043349 AA977711
GeneLoc Exon Structure
|
Expression
for WDHD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDHD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTTTGTGT
About this image
See WDHD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDHD1
SOURCE GeneReport for Unigene cluster: Hs.385998
SABiosciences Custom PCR Arrays for WDHD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDHD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDHD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDHD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDHD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDHD1 |
Orthologs
for WDHD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WDHD1 gene from 10/32 species (see all 32) About this table
ENSEMBL Gene Tree for WDHD1 (if available)
TreeFam Gene Tree for WDHD1 (if available) |
Paralogs
for WDHD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WDHD1 gene
WDHD1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for WDHD1
PGOHUM00000248176
|
Genomic Variants
for WDHD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDHD1 (55405656 - 55493823 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WDHD1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDHD1 |
|
Disorders
/ Diseases
for WDHD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDHD1 for disorders About GeneDecksing
OMIM gene information: 608126
OMIM disorders: --
7  diseases for WDHD1: About MalaCardstrench fever yellow fever syringomyelia agoraphobia
meningioma esophagitis leukemia
1 disease from the University of Copenhagen DISEASES database for WDHD1:Trench fever Human Genome Epidemiology (HuGE) Navigator: WDHD1 (5 documents)
Export disorders for WDHD1 gene to outside databases
|
Publications
for WDHD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDHD1 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with WDHD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Activation of WD repeat and high-mobility group box D NA binding protein 1 in pulmonary and esophageal carcinogenesis. (PubMed id 20028748)1, 3 Sato N....Daigo Y. (2010)
- Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. (PubMed id 19805216)1, 2 Im J.S.... Lee J.K. (2009)
- Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. (PubMed id 17761813)1, 2 Zhu W....Dutta A. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- AND-1, a natural chimeric DNA-binding protein, combines an HMG-box with regulatory WD-repeats. (PubMed id 9175701)1, 3 Kohler A....Franke W.W. (1997)
- And-1 is required for the stability of histone acetylt ransferase Gcn5. (PubMed id 21725360)1 Li Y....Zhu W. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- The involvement of acidic nucleoplasmic DNA-binding pr otein (And-1) in the regulation of prereplicative complex (pre-RC) assembly in h uman cells. (PubMed id 23093411)1 Li Y....Zhu W. (2012)
|
External Searches for WDHD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDHD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDHD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDHD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDHD1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDHD1 gene:
Search GeneIP for patents involving WDHD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDHD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WDHD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDHD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDHD1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WDHD1 | | OriGene 3'-UTR Clone for WDHD1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDHD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDHD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for WDHD1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDHD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDHD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDHD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDHD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDHD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDHD1 |
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 | | | WDHD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDHD1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for WDHD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDHD1 |
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