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Aliases & Descriptions for WDHD1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases AND-1 1 , 2 AND1 3 And-1 3
Descriptions Acidic nucleoplasmic DNA-binding protein 1 2 , 3 WD repeat and HMG-box DNA binding protein 1 2
Search outside databases for aliases for WDHD1 genePrevious GC identifers: GC14M053397 GC14M053372
Summaries for WDHD1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for WDHD1 : The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal highmobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and mayfunction as adaptor/regulatory modules in signal transduction, pre-mRNA processing andcytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatinassembly, transcription and replication. Alternative splicing results in two transcript variantsencoding different isoforms. [provided by RefSeq] UniProtKB/Swiss-Prot: WDHD1_HUMAN, O75717 Function : Binds DNA with high affinity. May also be involved in protein-protein interactions (Bysimilarity)
Genomic Location for WDHD1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the WDHD1 gene Entrez Gene cytogenetic band: 14q22.3 Ensembl cytogenetic band: 14q22.3 HGNC cytogenetic band: 14q22.2 WDHD1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14M054477:
(about GC identifiers )
Start:
54,476,692 bp from pter
End:
54,563,557 bp from pter
Size:
86,866 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000014.7 NT_026437.11 Proteins for WDHD1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: WDHD1_HUMAN, O75717 (See
protein sequence )Recommended Name: WD repeat and HMG-box DNA-binding protein 1 Size : 1129 amino acids; 125967 Da
Subcellular location : Nucleus, nucleoplasm (By similarity)
PDB structures from and Proteopedia : 2D7L (3D)
 
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001008397.1 NP_009017.1 ENSEMBL proteins: ENSP00000352085 ENSP00000353793 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for WDHD1: Assays for WDHD1:
Protein
Domains/ Families for WDHD1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O75717 ProtoNet protein and cluster: O75717
1 Blocks protein family : IPB001680 G-protein beta WD-40 repeat signature UniProtKB/Swiss-Prot: WDHD1_HUMAN, O75717 Similarity : Contains 1 HMG box DNA-binding domainSimilarity : Contains 7 WD repeats
Gene Function for WDHD1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
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RNAi Products ,
Clones , and
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Millipore ,
OriGene , and/or
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siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001008396 Applied Biosystems Silencer ® siRNAs for WDHD1 Sigma-Aldrich siRNA for WDHD1 Sigma-Aldrich shRNA for WDHD1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001008396                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001008396                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001008396  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_007086 UniProtKB/Swiss-Prot: WDHD1_HUMAN, O75717 Function : Binds DNA with high affinity. May also be involved in protein-protein interactions (Bysimilarity)
1 Gene Ontology (GO) molecular function term (links to tree view) :
About this table
Pathways & Interactions for WDHD1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for WDHD1 1 Interacting protein for WDHD1 (ENSP00000353793 3 ) via UniProtKB, MINT, and/or STRING About this table
Drugs & Compounds for WDHD1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for WDHD1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
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shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001008396 Sigma-Aldrich siRNA for WDHD1 Sigma-Aldrich shRNA for WDHD1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001008396 NM_007086
REFSEQ mRNAs for WDHD1 gene (2 alternative transcripts): NM_001008396.1 NM_007086.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001008396 NM_007086
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001008396                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001008396                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001008396  
Additional cDNA sequence: AJ006266.1 AK001538.1 AK001585.1 AK001620.1 AK293005.1 AY517556.1 BC000622.2 BC005040.1 BC043349.1 BC063041.1
11 DOTS entries : DT.107598 DT.97817273 DT.120786586 DT.101980015 DT.86857255 DT.97793240 DT.100023279 DT.440168 DT.95365607 DT.95365608 DT.99931138
24/112 AceView cDNA sequences (see all 112
):AI203233 BQ439066 AL709945 BM978997 AA315413 BE274400 AW613020 AK001538 BU509101 BC000622 BC063041 CB122476 AI126514 AI339309 CF529821 AA732499 AW500820 AI275133 BC043349 BC005040 BQ012014 BE046969 BQ435406 AI080213
highest scoring ESTs for WDHD1 :AA315413 AJ006266 AW961190 BC000622 BC005040 BC043349 BC063041 BE274400 BE275392 BE386196
Unigene Cluster for WDHD1: WD repeat and HMG-box DNA binding protein 1 Hs.385998 [show with all ESTs ] Unigene Representative Sequence: NM_007086 GeneLoc Exon Structure 2 Ensembl transcripts including schematic representations : ENST00000359167
ENST00000360586
Expression for WDHD1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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WDHD1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for WDHD1 1 / 2 / 3
7 probe-sets matching WDHD1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TATTTTGTGTSOURCE GeneReport for Unigene cluster: Hs.385998 Expression variation in blood from EXPOLDB for WDHD1
Orthologs for WDHD1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for WDHD1 gene from 5/15 species (see all 15
)
About this table Species with no ortholog for WDHD1 ENSEMBL Gene Tree for WDHD1 Paralogs for WDHD1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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SNPs/Variants for WDHD1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for WDHD1 (up to first 250kb)
Disorders & Mutations for WDHD1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 608126
Medical News for WDHD1 (Possibly Related Articles in
Doctor's Guide )
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Publications for WDHD1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/11 PubMed articles for WDHD1 gene (see all 11
): Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935) 3, 4 Beausoleil S.A....Gygi S.P. (2004) AND-1, a natural chimeric DNA-binding protein, combines an HMG-box with regulatory WD-repeats. (PubMed id 9175701) 2, 3 Kohler A....Franke W.W. (1997) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 3 Barbe L....Andersson-Svahn H. (2008) Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. (PubMed id 17761813) 3 Zhu W....Dutta A. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332) 4 Matsuoka S.... Elledge S.J. (2007) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3 Ota T....Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002)
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Genome Databases showing WDHD1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing WDHD1
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Specialized Databases showing WDHD1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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