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Aliases for WDHD1 Gene

Aliases for WDHD1 Gene

  • WD Repeat And HMG-Box DNA Binding Protein 1 2 3
  • Acidic Nucleoplasmic DNA-Binding Protein 1 3 4
  • AND-1 3 4
  • CTF4 2 3
  • AND1 3 4
  • Chromosome Transmission Fidelity Factor 4 Homolog (S. Cerevisiae) 2
  • CTF4, Chromosome Transmission Fidelity Factor 4 Homolog 3
  • WD Repeat And HMG-Box DNA-Binding Protein 1 3
  • CHTF4 3

External Ids for WDHD1 Gene

Previous GeneCards Identifiers for WDHD1 Gene

  • GC14M053397
  • GC14M053372
  • GC14M054477
  • GC14M055405
  • GC14M035568

Summaries for WDHD1 Gene

Entrez Gene Summary for WDHD1 Gene

  • The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDHD1 Gene

WDHD1 (WD Repeat And HMG-Box DNA Binding Protein 1) is a Protein Coding gene. Diseases associated with WDHD1 include trench fever. GO annotations related to this gene include RNA binding and RNA polymerase binding.

UniProtKB/Swiss-Prot for WDHD1 Gene

  • Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDHD1 Gene

Genomics for WDHD1 Gene

Regulatory Elements for WDHD1 Gene

Genomic Location for WDHD1 Gene

54,938,938 bp from pter
55,027,105 bp from pter
88,168 bases
Minus strand

Genomic View for WDHD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDHD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDHD1 Gene

Proteins for WDHD1 Gene

  • Protein details for WDHD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat and HMG-box DNA-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • C9JW18
    • F6W0U7

    Protein attributes for WDHD1 Gene

    1129 amino acids
    Molecular mass:
    125967 Da
    Quaternary structure:
    • Interacts with the polymerase alpha catalytic subunit POLA1. Interacts with MCM10. Interacts with DNA2.

    Three dimensional structures from OCA and Proteopedia for WDHD1 Gene

    Alternative splice isoforms for WDHD1 Gene


neXtProt entry for WDHD1 Gene

Proteomics data for WDHD1 Gene at MOPED

Post-translational modifications for WDHD1 Gene

  • Ubiquitination at Lys130 and Lys811
  • Modification sites at PhosphoSitePlus

Other Protein References for WDHD1 Gene

Antibody Products

No data available for DME Specific Peptides for WDHD1 Gene

Domains for WDHD1 Gene

Gene Families for WDHD1 Gene

  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for WDHD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • O75717
  • Contains 1 HMG box DNA-binding domain.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDHD1: view

Function for WDHD1 Gene

Molecular function for WDHD1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.

Gene Ontology (GO) - Molecular Function for WDHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 21725360
GO:0070063 RNA polymerase binding IEA --
genes like me logo Genes that share ontologies with WDHD1: view

Phenotypes for WDHD1 Gene

GenomeRNAi human phenotypes for WDHD1:
genes like me logo Genes that share phenotypes with WDHD1: view

Animal Model Products

miRNA for WDHD1 Gene

miRTarBase miRNAs that target WDHD1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDHD1 Gene

Localization for WDHD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDHD1 Gene

Nucleus, nucleoplasm.

Subcellular locations from

Jensen Localization Image for WDHD1 Gene COMPARTMENTS Subcellular localization image for WDHD1 gene
Compartment Confidence
nucleus 4
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for WDHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 9175701
genes like me logo Genes that share ontologies with WDHD1: view

Pathways for WDHD1 Gene

SuperPathways for WDHD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
GO:0033044 regulation of chromosome organization IEA --
GO:0070829 heterochromatin maintenance IEA --
genes like me logo Genes that share ontologies with WDHD1: view

No data available for Pathways by source for WDHD1 Gene

Transcripts for WDHD1 Gene

Unigene Clusters for WDHD1 Gene

WD repeat and HMG-box DNA binding protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDHD1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDHD1 Gene

No ASD Table

Relevant External Links for WDHD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDHD1 Gene

mRNA expression in normal human tissues for WDHD1 Gene

Protein differential expression in normal tissues for WDHD1 Gene

This gene is overexpressed in Serum (52.3) and Pancreatic juice (11.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDHD1 Gene

SOURCE GeneReport for Unigene cluster for WDHD1 Gene Hs.385998

genes like me logo Genes that share expressions with WDHD1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for WDHD1 Gene

Orthologs for WDHD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDHD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDHD1 35
  • 90.87 (n)
  • 88.98 (a)
WDHD1 36
  • 89 (a)
(Canis familiaris)
Mammalia WDHD1 35
  • 91.53 (n)
  • 89.94 (a)
WDHD1 36
  • 89 (a)
(Mus musculus)
Mammalia Wdhd1 35
  • 85 (n)
  • 83.89 (a)
Wdhd1 16
Wdhd1 36
  • 84 (a)
(Pan troglodytes)
Mammalia WDHD1 35
  • 99.73 (n)
  • 99.47 (a)
WDHD1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Wdhd1 35
  • 83.93 (n)
  • 82.44 (a)
(Monodelphis domestica)
Mammalia WDHD1 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
-- 36
  • 69 (a)
(Gallus gallus)
Aves WDHD1 35
  • 73.23 (n)
  • 72.15 (a)
WDHD1 36
  • 71 (a)
(Anolis carolinensis)
Reptilia WDHD1 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19641 35
wdhd1 35
  • 66.58 (n)
  • 65.26 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397870 35
(Danio rerio)
Actinopterygii wdhd1 35
  • 62.27 (n)
  • 62.45 (a)
wufa11f10 35
wdhd1 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007423 35
  • 43.81 (n)
  • 33.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ctf4 35
  • 43.85 (n)
  • 32.75 (a)
Ctf4 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea F17C11.10 36
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTF4 36
  • 19 (a)
CTF4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G42660 35
  • 44.88 (n)
  • 30.06 (a)
(Oryza sativa)
Liliopsida Os09g0241100 35
  • 44.85 (n)
  • 32.17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1213 36
  • 38 (a)
Species with no ortholog for WDHD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDHD1 Gene

Gene Tree for WDHD1 (if available)
Gene Tree for WDHD1 (if available)

Paralogs for WDHD1 Gene Pseudogenes for WDHD1 Gene

genes like me logo Genes that share paralogs with WDHD1: view

No data available for Paralogs for WDHD1 Gene

Variants for WDHD1 Gene

Sequence variations from dbSNP and Humsavar for WDHD1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1354 -- 54,940,274(+) TCTCC(A/G)AACCT utr-variant-3-prime
rs878944 -- 54,976,884(+) ATCAC(A/G)TAATA intron-variant
rs943914 -- 54,973,350(-) ACATT(G/T)TCACT intron-variant
rs1055245 -- 54,939,178(-) TTATC(A/C)GAATA utr-variant-3-prime
rs1064087 -- 54,940,035(-) TTTGT(C/T)ATTAG utr-variant-3-prime

Relevant External Links for WDHD1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for WDHD1 Gene

Disorders for WDHD1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for WDHD1 Gene in MalaCards »

(1) Diseases for WDHD1 Gene including...

(1) University of Copenhagen DISEASES for WDHD1 Gene

Relevant External Links for WDHD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with WDHD1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for WDHD1 Gene

Publications for WDHD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 48
  3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 48
  4. AND-1, a natural chimeric DNA-binding protein, combines an HMG-box with regulatory WD-repeats. (PMID: 9175701) KAPhler A. … Franke W.W. (J. Cell. Sci. 1997) 2 3
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for WDHD1 Gene

Sources for WDHD1 Gene

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