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Aliases for WDHD1 Gene

Aliases for WDHD1 Gene

  • WD Repeat And HMG-Box DNA Binding Protein 1 2 3 5
  • Acidic Nucleoplasmic DNA-Binding Protein 1 3 4
  • AND-1 3 4
  • CTF4 2 3
  • AND1 3 4
  • Chromosome Transmission Fidelity Factor 4 Homolog (S. Cerevisiae) 2
  • CTF4, Chromosome Transmission Fidelity Factor 4 Homolog 3
  • CHTF4 3

External Ids for WDHD1 Gene

Previous GeneCards Identifiers for WDHD1 Gene

  • GC14M053397
  • GC14M053372
  • GC14M054477
  • GC14M055405
  • GC14M035568

Summaries for WDHD1 Gene

Entrez Gene Summary for WDHD1 Gene

  • The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDHD1 Gene

WDHD1 (WD Repeat And HMG-Box DNA Binding Protein 1) is a Protein Coding gene. Diseases associated with WDHD1 include Trench Fever and Bronchus Cancer. GO annotations related to this gene include RNA binding and RNA polymerase binding.

UniProtKB/Swiss-Prot for WDHD1 Gene

  • Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDHD1 Gene

Genomics for WDHD1 Gene

Regulatory Elements for WDHD1 Gene

Enhancers for WDHD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDHD1 on UCSC Golden Path with GeneCards custom track

Promoters for WDHD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDHD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDHD1 Gene

54,938,938 bp from pter
55,027,105 bp from pter
88,168 bases
Minus strand

Genomic View for WDHD1 Gene

Genes around WDHD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDHD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDHD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDHD1 Gene

Proteins for WDHD1 Gene

  • Protein details for WDHD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat and HMG-box DNA-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • C9JW18
    • F6W0U7

    Protein attributes for WDHD1 Gene

    1129 amino acids
    Molecular mass:
    125967 Da
    Quaternary structure:
    • Interacts with the polymerase alpha catalytic subunit POLA1. Interacts with MCM10. Interacts with DNA2.

    Three dimensional structures from OCA and Proteopedia for WDHD1 Gene

    Alternative splice isoforms for WDHD1 Gene


neXtProt entry for WDHD1 Gene

Proteomics data for WDHD1 Gene at MOPED

Post-translational modifications for WDHD1 Gene

  • Ubiquitination at Lys 130 and Lys 811
  • Modification sites at PhosphoSitePlus

Other Protein References for WDHD1 Gene

No data available for DME Specific Peptides for WDHD1 Gene

Domains & Families for WDHD1 Gene

Gene Families for WDHD1 Gene

Suggested Antigen Peptide Sequences for WDHD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 HMG box DNA-binding domain.
  • Contains 7 WD repeats.
  • Contains 1 HMG box DNA-binding domain.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDHD1: view

Function for WDHD1 Gene

Molecular function for WDHD1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.

Gene Ontology (GO) - Molecular Function for WDHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with WDHD1: view
genes like me logo Genes that share phenotypes with WDHD1: view

Animal Model Products

miRNA for WDHD1 Gene

miRTarBase miRNAs that target WDHD1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDHD1 Gene

Localization for WDHD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDHD1 Gene

Nucleus, nucleoplasm.

Subcellular locations from

Jensen Localization Image for WDHD1 Gene COMPARTMENTS Subcellular localization image for WDHD1 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for WDHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9175701
genes like me logo Genes that share ontologies with WDHD1: view

Pathways & Interactions for WDHD1 Gene

SuperPathways for WDHD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDHD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDHD1 Gene

Drugs & Compounds for WDHD1 Gene

No Compound Related Data Available

Transcripts for WDHD1 Gene

Unigene Clusters for WDHD1 Gene

WD repeat and HMG-box DNA binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDHD1 Gene

No ASD Table

Relevant External Links for WDHD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDHD1 Gene

mRNA expression in normal human tissues for WDHD1 Gene

Protein differential expression in normal tissues from HIPED for WDHD1 Gene

This gene is overexpressed in Serum (52.3) and Pancreatic juice (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDHD1 Gene

SOURCE GeneReport for Unigene cluster for WDHD1 Gene Hs.385998

genes like me logo Genes that share expression patterns with WDHD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for WDHD1 Gene

Orthologs for WDHD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDHD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDHD1 35
  • 90.87 (n)
  • 88.98 (a)
WDHD1 36
  • 89 (a)
(Canis familiaris)
Mammalia WDHD1 35
  • 91.53 (n)
  • 89.94 (a)
WDHD1 36
  • 89 (a)
(Mus musculus)
Mammalia Wdhd1 35
  • 85 (n)
  • 83.89 (a)
Wdhd1 16
Wdhd1 36
  • 84 (a)
(Pan troglodytes)
Mammalia WDHD1 35
  • 99.73 (n)
  • 99.47 (a)
WDHD1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Wdhd1 35
  • 83.93 (n)
  • 82.44 (a)
(Monodelphis domestica)
Mammalia WDHD1 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
-- 36
  • 69 (a)
(Gallus gallus)
Aves WDHD1 35
  • 73.23 (n)
  • 72.15 (a)
WDHD1 36
  • 71 (a)
(Anolis carolinensis)
Reptilia WDHD1 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19641 35
wdhd1 35
  • 66.58 (n)
  • 65.26 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397870 35
(Danio rerio)
Actinopterygii wdhd1 35
  • 62.27 (n)
  • 62.45 (a)
wufa11f10 35
wdhd1 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007423 35
  • 43.81 (n)
  • 33.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ctf4 35
  • 43.85 (n)
  • 32.75 (a)
Ctf4 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea F17C11.10 36
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTF4 36
  • 19 (a)
CTF4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G42660 35
  • 44.88 (n)
  • 30.06 (a)
(Oryza sativa)
Liliopsida Os09g0241100 35
  • 44.85 (n)
  • 32.17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1213 36
  • 38 (a)
Species with no ortholog for WDHD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDHD1 Gene

Gene Tree for WDHD1 (if available)
Gene Tree for WDHD1 (if available)

Paralogs for WDHD1 Gene Pseudogenes for WDHD1 Gene

genes like me logo Genes that share paralogs with WDHD1: view

No data available for Paralogs for WDHD1 Gene

Variants for WDHD1 Gene

Sequence variations from dbSNP and Humsavar for WDHD1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs8020032 - 54,995,744(+) TAGAA(A/G)ATCAC intron-variant, reference, missense
rs17128116 - 54,991,322(+) GTGGT(A/G)GATTG reference, missense
rs41309252 - 54,941,576(+) GTTCT(C/T)TTTTG reference, missense
rs7492958 -- 54,940,814(+) AAATT(A/G)TGGTA utr-variant-3-prime
rs8003017 -- 54,948,265(+) tcacc(C/T)gggaa intron-variant

Variation tolerance for WDHD1 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.12; 80.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for WDHD1 Gene

Disorders for WDHD1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for WDHD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
trench fever
  • his-werner disease
bronchus cancer
  • malignant neoplasm of bronchus and lung, unspecified
- elite association - COSMIC cancer census association via MalaCards
Search WDHD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WDHD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with WDHD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDHD1 Gene

Publications for WDHD1 Gene

  1. Activation of WD repeat and high-mobility group box DNA binding protein 1 in pulmonary and esophageal carcinogenesis. (PMID: 20028748) Sato N. … Daigo Y. (Clin. Cancer Res. 2010) 2 3 67
  2. AND-1, a natural chimeric DNA-binding protein, combines an HMG-box with regulatory WD-repeats. (PMID: 9175701) KAPhler A. … Franke W.W. (J. Cell. Sci. 1997) 2 3
  3. RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells. (PMID: 25602958) Im J.S. … Lee J.K. (Cell Cycle 2015) 3
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for WDHD1 Gene

Sources for WDHD1 Gene