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Aliases for WDHD1 Gene

Aliases for WDHD1 Gene

  • WD Repeat And HMG-Box DNA Binding Protein 1 2 3 5
  • Acidic Nucleoplasmic DNA-Binding Protein 1 3 4
  • AND-1 3 4
  • AND1 3 4
  • CTF4, Chromosome Transmission Fidelity Factor 4 Homolog (S. Cerevisiae) 2
  • CTF4, Chromosome Transmission Fidelity Factor 4 Homolog 3
  • WD Repeat And HMG-Box DNA-Binding Protein 1 3
  • CHTF4 3
  • CTF4 3

External Ids for WDHD1 Gene

Previous GeneCards Identifiers for WDHD1 Gene

  • GC14M053397
  • GC14M053372
  • GC14M054477
  • GC14M055405
  • GC14M035568

Summaries for WDHD1 Gene

Entrez Gene Summary for WDHD1 Gene

  • The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDHD1 Gene

WDHD1 (WD Repeat And HMG-Box DNA Binding Protein 1) is a Protein Coding gene. Diseases associated with WDHD1 include Trench Fever. Among its related pathways are Mesodermal Commitment Pathway. GO annotations related to this gene include RNA binding and RNA polymerase binding.

UniProtKB/Swiss-Prot for WDHD1 Gene

  • Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDHD1 Gene

Genomics for WDHD1 Gene

Regulatory Elements for WDHD1 Gene

Enhancers for WDHD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G055113 2.1 FANTOM5 Ensembl ENCODE dbSUPER 15.2 -96.9 -96879 21.7 MLX ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 LOC105370509 LGALS3 ATG14 WDHD1 GCH1 FBXO34 DLGAP5 SOCS4 ENSG00000259318 MAPK1IP1L
GH14G055598 1.6 Ensembl ENCODE dbSUPER 15.1 -573.3 -573325 3.7 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS DEK SP5 ZHX2 KTN1-AS1 ATG14 WDHD1 KTN1 TBPL2 SOCS4 GC14P055652
GH14G055050 1.4 ENCODE dbSUPER 15.4 -25.2 -25202 3.2 HDGF HNRNPUL1 PKNOX1 MLX ARNT CREB3L1 AGO1 WRNIP1 ARID4B SIN3A LOC105370509 WDHD1 ATG14 MAPK1IP1L GC14M055059 GC14M055058
GH14G054395 1.1 ENCODE 13.8 +629.9 629855 2.7 HDGF PKNOX1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 ZNF143 SOCS4 WDHD1 CNIH1 CDKN3
GH14G054782 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4.2 +242.9 242866 3.7 CTCF MAX CEBPG RAD21 YY1 FOSL1 EED HNF4G ETV6 TRIM24 SAMD4A GCH1 WDHD1 GMFB FBXO34 LGALS3 MAPK1IP1L PIR45415 GC14P054860
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDHD1 on UCSC Golden Path with GeneCards custom track

Promoters for WDHD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000068787 -395 2601 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for WDHD1 Gene

Chromosome:
14
Start:
54,938,938 bp from pter
End:
55,027,105 bp from pter
Size:
88,168 bases
Orientation:
Minus strand

Genomic View for WDHD1 Gene

Genes around WDHD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDHD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDHD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDHD1 Gene

Proteins for WDHD1 Gene

  • Protein details for WDHD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75717-WDHD1_HUMAN
    Recommended name:
    WD repeat and HMG-box DNA-binding protein 1
    Protein Accession:
    O75717
    Secondary Accessions:
    • C9JW18
    • F6W0U7

    Protein attributes for WDHD1 Gene

    Size:
    1129 amino acids
    Molecular mass:
    125967 Da
    Quaternary structure:
    • Interacts with the polymerase alpha catalytic subunit POLA1. Interacts with MCM10. Interacts with DNA2.

    Three dimensional structures from OCA and Proteopedia for WDHD1 Gene

    Alternative splice isoforms for WDHD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDHD1 Gene

Post-translational modifications for WDHD1 Gene

  • Ubiquitination at Lys130 and Lys811
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WDHD1 Gene

Domains & Families for WDHD1 Gene

Gene Families for WDHD1 Gene

Suggested Antigen Peptide Sequences for WDHD1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDHD1: view

No data available for UniProtKB/Swiss-Prot for WDHD1 Gene

Function for WDHD1 Gene

Molecular function for WDHD1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.

Gene Ontology (GO) - Molecular Function for WDHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21725360
genes like me logo Genes that share ontologies with WDHD1: view
genes like me logo Genes that share phenotypes with WDHD1: view

Animal Model Products

CRISPR Products

miRNA for WDHD1 Gene

miRTarBase miRNAs that target WDHD1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDHD1 Gene

Localization for WDHD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDHD1 Gene

Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDHD1 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for WDHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IEA,TAS --
GO:0005737 cytoplasm TAS 9175701
genes like me logo Genes that share ontologies with WDHD1: view

Pathways & Interactions for WDHD1 Gene

genes like me logo Genes that share pathways with WDHD1: view

Pathways by source for WDHD1 Gene

2 BioSystems pathways for WDHD1 Gene

Gene Ontology (GO) - Biological Process for WDHD1 Gene

None

No data available for SIGNOR curated interactions for WDHD1 Gene

Drugs & Compounds for WDHD1 Gene

No Compound Related Data Available

Transcripts for WDHD1 Gene

Unigene Clusters for WDHD1 Gene

WD repeat and HMG-box DNA binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDHD1 Gene

No ASD Table

Relevant External Links for WDHD1 Gene

GeneLoc Exon Structure for
WDHD1
ECgene alternative splicing isoforms for
WDHD1

Expression for WDHD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDHD1 Gene

Protein differential expression in normal tissues from HIPED for WDHD1 Gene

This gene is overexpressed in Serum (52.3) and Pancreatic juice (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDHD1 Gene



NURSA nuclear receptor signaling pathways regulating expression of WDHD1 Gene:

WDHD1

SOURCE GeneReport for Unigene cluster for WDHD1 Gene:

Hs.385998

Evidence on tissue expression from TISSUES for WDHD1 Gene

  • Liver(4.2)
  • Skin(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with WDHD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDHD1 Gene

Orthologs for WDHD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDHD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDHD1 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia WDHD1 34 35
  • 91.53 (n)
cow
(Bos Taurus)
Mammalia WDHD1 34 35
  • 90.87 (n)
mouse
(Mus musculus)
Mammalia Wdhd1 34 16 35
  • 85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 84 (a)
OneToMany
-- 35
  • 69 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Wdhd1 34
  • 83.93 (n)
oppossum
(Monodelphis domestica)
Mammalia WDHD1 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDHD1 34 35
  • 73.23 (n)
lizard
(Anolis carolinensis)
Reptilia WDHD1 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdhd1 34
  • 66.58 (n)
Str.19641 34
African clawed frog
(Xenopus laevis)
Amphibia LOC397870 34
zebrafish
(Danio rerio)
Actinopterygii wdhd1 34 35
  • 62.27 (n)
wufa11f10 34
fruit fly
(Drosophila melanogaster)
Insecta Ctf4 34 35
  • 43.85 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007423 34
  • 43.81 (n)
worm
(Caenorhabditis elegans)
Secernentea F17C11.10 35
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTF4 35 37
  • 19 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G42660 34
  • 44.88 (n)
rice
(Oryza sativa)
Liliopsida Os09g0241100 34
  • 44.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1213 35
  • 38 (a)
OneToOne
Species where no ortholog for WDHD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDHD1 Gene

ENSEMBL:
Gene Tree for WDHD1 (if available)
TreeFam:
Gene Tree for WDHD1 (if available)

Paralogs for WDHD1 Gene

Pseudogenes.org Pseudogenes for WDHD1 Gene

genes like me logo Genes that share paralogs with WDHD1: view

No data available for Paralogs for WDHD1 Gene

Variants for WDHD1 Gene

Sequence variations from dbSNP and Humsavar for WDHD1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000021160 -- 55,011,674(+) ATTTA(-/TTTATT)TTAAC intron-variant, upstream-variant-2KB
rs1000034619 -- 54,974,475(+) GACCA(C/T)AAAAC intron-variant
rs1000052505 -- 55,022,240(+) GTCTA(A/G)GTCTT intron-variant
rs1000069239 -- 55,016,078(+) CAATG(A/G)AAAAT intron-variant
rs1000072326 -- 55,026,825(+) AAAGC(C/T)AGTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WDHD1 Gene

Variant ID Type Subtype PubMed ID
nsv1038242 CNV loss 25217958
nsv1134378 CNV deletion 24896259
nsv976342 CNV duplication 23825009

Variation tolerance for WDHD1 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.12; 80.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDHD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDHD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDHD1 Gene

Disorders for WDHD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WDHD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
trench fever
  • his-werner disease
- elite association - COSMIC cancer census association via MalaCards
Search WDHD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WDHD1

Genetic Association Database (GAD)
WDHD1
Human Genome Epidemiology (HuGE) Navigator
WDHD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDHD1
genes like me logo Genes that share disorders with WDHD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDHD1 Gene

Publications for WDHD1 Gene

  1. Activation of WD repeat and high-mobility group box DNA binding protein 1 in pulmonary and esophageal carcinogenesis. (PMID: 20028748) Sato N. … Daigo Y. (Clin. Cancer Res. 2010) 2 3 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
  4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 46 64
  5. Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. (PMID: 19805216) Im J.S. … Lee J.K. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4 64

Products for WDHD1 Gene

Sources for WDHD1 Gene

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