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Aliases for WDHD1 Gene

Aliases for WDHD1 Gene

  • WD Repeat And HMG-Box DNA Binding Protein 1 2 3
  • Acidic Nucleoplasmic DNA-Binding Protein 1 3 4
  • AND-1 3 4
  • CTF4 2 3
  • AND1 3 4
  • Chromosome Transmission Fidelity Factor 4 Homolog (S. Cerevisiae) 2
  • CTF4, Chromosome Transmission Fidelity Factor 4 Homolog 3
  • WD Repeat And HMG-Box DNA-Binding Protein 1 3
  • CHTF4 3

External Ids for WDHD1 Gene

Summaries for WDHD1 Gene

Entrez Gene Summary for WDHD1 Gene

  • The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDHD1 Gene

WDHD1 (WD Repeat And HMG-Box DNA Binding Protein 1) is a Protein Coding gene. Diseases associated with WDHD1 include trench fever. GO annotations related to this gene include RNA binding and RNA polymerase binding.

UniProtKB/Swiss-Prot for WDHD1 Gene

  • Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDHD1 Gene

Genomics for WDHD1 Gene

Genomic Location for WDHD1 Gene

Start:
54,938,938 bp from pter
End:
55,027,105 bp from pter
Size:
88,168 bases
Orientation:
Minus strand

Genomic View for WDHD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDHD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDHD1 Gene

Regulatory Elements for WDHD1 Gene

Proteins for WDHD1 Gene

  • Protein details for WDHD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75717-WDHD1_HUMAN
    Recommended name:
    WD repeat and HMG-box DNA-binding protein 1
    Protein Accession:
    O75717
    Secondary Accessions:
    • C9JW18
    • F6W0U7

    Protein attributes for WDHD1 Gene

    Size:
    1129 amino acids
    Molecular mass:
    125967 Da
    Quaternary structure:
    • Interacts with the polymerase alpha catalytic subunit POLA1. Interacts with MCM10. Interacts with DNA2.

    Three dimensional structures from OCA and Proteopedia for WDHD1 Gene

    Alternative splice isoforms for WDHD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDHD1 Gene

Proteomics data for WDHD1 Gene at MOPED

Post-translational modifications for WDHD1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys130 and Lys811

Other Protein References for WDHD1 Gene

No data available for DME Specific Peptides for WDHD1 Gene

Domains for WDHD1 Gene

Gene Families for WDHD1 Gene

HGNC:
  • WDR :WD repeat domain containing

UniProtKB/Swiss-Prot:

WDHD1_HUMAN
Domain:
  • Contains 1 HMG box DNA-binding domain.:
    • O75717
Similarity:
  • Contains 7 WD repeats.:
    • O75717
genes like me logo Genes that share domains with WDHD1: view

Function for WDHD1 Gene

Molecular function for WDHD1 Gene

UniProtKB/Swiss-Prot Function: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.

Gene Ontology (GO) - Molecular Function for WDHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 21725360
GO:0070063 RNA polymerase binding IEA --
genes like me logo Genes that share ontologies with WDHD1: view

Phenotypes for WDHD1 Gene

GenomeRNAi human phenotypes for WDHD1:
genes like me logo Genes that share phenotypes with WDHD1: view

miRNA for WDHD1 Gene

miRTarBase miRNAs that target WDHD1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDHD1 Gene

Localization for WDHD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDHD1 Gene

Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDHD1 Gene COMPARTMENTS Subcellular localization image for WDHD1 gene
Compartment Confidence
nucleus 4
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for WDHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 9175701
genes like me logo Genes that share ontologies with WDHD1: view

Pathways for WDHD1 Gene

SuperPathways for WDHD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
GO:0033044 regulation of chromosome organization IEA --
GO:0070829 heterochromatin maintenance IEA --
genes like me logo Genes that share ontologies with WDHD1: view

No data available for Pathways by source for WDHD1 Gene

Transcripts for WDHD1 Gene

Unigene Clusters for WDHD1 Gene

WD repeat and HMG-box DNA binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDHD1 Gene

No ASD Table

Relevant External Links for WDHD1 Gene

GeneLoc Exon Structure for
WDHD1
ECgene alternative splicing isoforms for
WDHD1

Expression for WDHD1 Gene

mRNA expression in normal human tissues for WDHD1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDHD1 Gene

SOURCE GeneReport for Unigene cluster for WDHD1 Gene Hs.385998

genes like me logo Genes that share expressions with WDHD1: view

Orthologs for WDHD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDHD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDHD1 36
  • 99.73 (n)
  • 99.47 (a)
WDHD1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDHD1 36
  • 90.87 (n)
  • 88.98 (a)
WDHD1 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDHD1 36
  • 91.53 (n)
  • 89.94 (a)
WDHD1 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdhd1 36
  • 85 (n)
  • 83.89 (a)
Wdhd1 16
Wdhd1 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDHD1 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 84 (a)
OneToMany
-- 37
  • 69 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Wdhd1 36
  • 83.93 (n)
  • 82.44 (a)
chicken
(Gallus gallus)
Aves WDHD1 36
  • 73.23 (n)
  • 72.15 (a)
WDHD1 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDHD1 37
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397870 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19641 36
wdhd1 36
  • 66.58 (n)
  • 65.26 (a)
zebrafish
(Danio rerio)
Actinopterygii wdhd1 36
  • 62.27 (n)
  • 62.45 (a)
wdhd1 37
  • 61 (a)
OneToOne
wufa11f10 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007423 36
  • 43.81 (n)
  • 33.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ctf4 36
  • 43.85 (n)
  • 32.75 (a)
Ctf4 37
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F17C11.10 37
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTF4 37
  • 19 (a)
OneToOne
CTF4 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G42660 36
  • 44.88 (n)
  • 30.06 (a)
rice
(Oryza sativa)
Liliopsida Os09g0241100 36
  • 44.85 (n)
  • 32.17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1213 37
  • 38 (a)
OneToOne
Species with no ortholog for WDHD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDHD1 Gene

ENSEMBL:
Gene Tree for WDHD1 (if available)
TreeFam:
Gene Tree for WDHD1 (if available)

Paralogs for WDHD1 Gene

Pseudogenes.org Pseudogenes for WDHD1 Gene

genes like me logo Genes that share paralogs with WDHD1: view

No data available for Paralogs for WDHD1 Gene

Variants for WDHD1 Gene

Sequence variations from dbSNP and Humsavar for WDHD1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1354 -- 54,940,274(+) TCTCC(A/G)AACCT utr-variant-3-prime
rs878944 -- 54,976,884(+) ATCAC(A/G)TAATA intron-variant
rs943914 -- 54,973,350(-) ACATT(G/T)TCACT intron-variant
rs1055245 -- 54,939,178(-) TTATC(A/C)GAATA utr-variant-3-prime
rs1064087 -- 54,940,035(-) TTTGT(C/T)ATTAG utr-variant-3-prime

Relevant External Links for WDHD1 Gene

HapMap Linkage Disequilibrium report
WDHD1

No data available for Structural Variations from Database of Genomic Variants (DGV) for WDHD1 Gene

Disorders for WDHD1 Gene

(1) MalaCards Diseases for WDHD1 Gene

Search for WDHD1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for WDHD1 Gene

Relevant External Links for WDHD1

Genetic Association Database (GAD)
WDHD1
Human Genome Epidemiology (HuGE) Navigator
WDHD1
genes like me logo Genes that share disorders with WDHD1: view

No data available for UniProtKB/Swiss-Prot for WDHD1 Gene

Publications for WDHD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  2. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 49
  3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 49
  4. AND-1, a natural chimeric DNA-binding protein, combines an HMG-box with regulatory WD-repeats. (PMID: 9175701) KAPhler A. … Franke W.W. (J. Cell. Sci. 1997) 2 3
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for WDHD1 Gene

Sources for WDHD1 Gene

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