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Aliases for WDFY4 Gene

Aliases for WDFY4 Gene

  • WDFY Family Member 4 2 3
  • C10orf64 3 4
  • Chromosome 10 Open Reading Frame 64 2
  • EC 3.6.3.12 63
  • EC 3.5.1.18 63
  • KIAA1607 4

External Ids for WDFY4 Gene

Previous HGNC Symbols for WDFY4 Gene

  • C10orf64

Previous GeneCards Identifiers for WDFY4 Gene

  • GC10P049313
  • GC10U900444
  • GC10P049563
  • GC10P049892
  • GC10P044158

Summaries for WDFY4 Gene

GeneCards Summary for WDFY4 Gene

WDFY4 (WDFY Family Member 4) is a Protein Coding gene. GO annotations related to this gene include binding and phospholipid binding. An important paralog of this gene is WDFY3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDFY4 Gene

Genomics for WDFY4 Gene

Regulatory Elements for WDFY4 Gene

Genomic Location for WDFY4 Gene

Chromosome:
10
Start:
48,684,830 bp from pter
End:
48,982,956 bp from pter
Size:
298,127 bases
Orientation:
Plus strand

Genomic View for WDFY4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDFY4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDFY4 Gene

Proteins for WDFY4 Gene

  • Protein details for WDFY4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZS81-WDFY4_HUMAN
    Recommended name:
    WD repeat- and FYVE domain-containing protein 4
    Protein Accession:
    Q6ZS81
    Secondary Accessions:
    • B9ZVP2
    • Q86WZ4
    • Q8N4A3
    • Q8TEN7
    • Q96BE1
    • Q9H7H8
    • Q9HCG5

    Protein attributes for WDFY4 Gene

    Size:
    3184 amino acids
    Molecular mass:
    353610 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDFY4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDFY4 Gene

Proteomics data for WDFY4 Gene at MOPED

Selected DME Specific Peptides for WDFY4 Gene

Post-translational modifications for WDFY4 Gene

  • Ubiquitination at Lys 1317
  • Modification sites at PhosphoSitePlus

Other Protein References for WDFY4 Gene

Domains & Families for WDFY4 Gene

Gene Families for WDFY4 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZS81

UniProtKB/Swiss-Prot:

WDFY4_HUMAN :
  • Contains 1 BEACH domain.
  • Contains 5 WD repeats.
Domain:
  • Contains 1 BEACH domain.
Similarity:
  • Contains 5 WD repeats.
genes like me logo Genes that share domains with WDFY4: view

Function for WDFY4 Gene

Enzyme Numbers (IUBMB) for WDFY4 Gene

Gene Ontology (GO) - Molecular Function for WDFY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
GO:0005543 phospholipid binding IBA --
genes like me logo Genes that share ontologies with WDFY4: view

Phenotypes for WDFY4 Gene

GenomeRNAi human phenotypes for WDFY4:
genes like me logo Genes that share phenotypes with WDFY4: view

Animal Model Products

miRNA for WDFY4 Gene

miRTarBase miRNAs that target WDFY4

No data available for Molecular function , Animal Models , Transcription Factor Targets and HOMER Transcription for WDFY4 Gene

Localization for WDFY4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDFY4 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for WDFY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0012505 endomembrane system IBA --
GO:0016021 integral component of membrane IEA --
GO:0019898 extrinsic component of membrane IBA --
genes like me logo Genes that share ontologies with WDFY4: view

No data available for Subcellular locations from COMPARTMENTS for WDFY4 Gene

Pathways & Interactions for WDFY4 Gene

SuperPathways for WDFY4 Gene

No Data Available

Interacting Proteins for WDFY4 Gene

Gene Ontology (GO) - Biological Process for WDFY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016197 endosomal transport IBA --
genes like me logo Genes that share ontologies with WDFY4: view

No data available for Pathways by source and SIGNOR curated interactions for WDFY4 Gene

Drugs & Compounds for WDFY4 Gene

No Compound Related Data Available

Transcripts for WDFY4 Gene

mRNA/cDNA for WDFY4 Gene

(9) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WDFY4 Gene

WDFY family member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDFY4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^
SP1:
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 46a · 46b ^ 47 ^ 48 ^ 49a · 49b ^ 50 ^ 51 ^ 52 ^ 53 ^ 54a · 54b ^ 55 ^ 56 ^ 57 ^ 58 ^ 59 ^ 60a · 60b ^ 61 ^ 62 ^ 63 ^ 64a · 64b ^ 65 ^ 66a ·
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -

Relevant External Links for WDFY4 Gene

GeneLoc Exon Structure for
WDFY4
ECgene alternative splicing isoforms for
WDFY4

Expression for WDFY4 Gene

mRNA expression in normal human tissues for WDFY4 Gene

mRNA differential expression in normal tissues according to GTEx for WDFY4 Gene

This gene is overexpressed in Whole Blood (x7.4) and Spleen (x6.3).

Protein differential expression in normal tissues from HIPED for WDFY4 Gene

This gene is overexpressed in Blymphocyte (21.5), Pancreas (21.3), and Brain (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDFY4 Gene



SOURCE GeneReport for Unigene cluster for WDFY4 Gene Hs.287379

genes like me logo Genes that share expression patterns with WDFY4: view

Protein tissue co-expression partners for WDFY4 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for WDFY4 Gene

Orthologs for WDFY4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDFY4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDFY4 35
  • 85.74 (n)
  • 85.01 (a)
WDFY4 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDFY4 35
  • 85.52 (n)
  • 84.2 (a)
WDFY4 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdfy4 35
  • 82.71 (n)
  • 82.53 (a)
Wdfy4 16
Wdfy4 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDFY4 35
  • 98.27 (n)
  • 97.69 (a)
rat
(Rattus norvegicus)
Mammalia Wdfy4 35
  • 81.52 (n)
  • 80.63 (a)
oppossum
(Monodelphis domestica)
Mammalia WDFY4 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDFY4 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDFY4 35
  • 64.24 (n)
  • 59.63 (a)
WDFY4 36
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wdfy4 35
  • 54.03 (n)
  • 44.42 (a)
wdfy4 36
  • 42 (a)
OneToOne
Species with no ortholog for WDFY4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDFY4 Gene

ENSEMBL:
Gene Tree for WDFY4 (if available)
TreeFam:
Gene Tree for WDFY4 (if available)

Paralogs for WDFY4 Gene

Paralogs for WDFY4 Gene

(1) SIMAP similar genes for WDFY4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WDFY4: view

Variants for WDFY4 Gene

Sequence variations from dbSNP and Humsavar for WDFY4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs435750 -- 48,826,077(+) GATTT(A/G/T)TATGG intron-variant
rs726786 -- 48,790,524(+) AGAAA(G/T)GACTT intron-variant
rs730591 -- 48,765,108(-) TGTTC(C/T)ATTCA intron-variant
rs733394 -- 48,740,196(-) CAATC(A/C/T)GTCAC intron-variant
rs950275 -- 48,689,174(-) AACGG(G/T)TAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDFY4 Gene

Variant ID Type Subtype PubMed ID
nsv7203 OTHER Inversion 18451855
nsv895365 CNV Loss 21882294
nsv895369 CNV Gain 21882294
nsv895371 CNV Gain 21882294
nsv895372 CNV Gain 21882294
nsv895373 CNV Loss 21882294
nsv512162 CNV Loss 21212237
esv2472494 CNV Deletion 19546169
esv1991692 CNV Deletion 18987734
nsv523003 CNV Loss 19592680
esv5318 CNV Deletion 18987735
esv999945 CNV Deletion 20482838
esv2736474 CNV Deletion 23290073
esv1063968 CNV Deletion 17803354
esv9654 CNV Loss 19470904
esv2670385 CNV Deletion 23128226
nsv895374 CNV Gain 21882294
nsv831865 CNV Gain 17160897
nsv516774 CNV Loss 19592680
esv8160 CNV Gain 19470904
esv32989 CNV Loss 17666407
esv2665419 CNV Deletion 23128226
nsv517287 CNV Loss 19592680
nsv831866 CNV Gain+Loss 17160897

Variation tolerance for WDFY4 Gene

Gene Damage Index Score: 15.01; 96.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDFY4 Gene

HapMap Linkage Disequilibrium report
WDFY4
Human Gene Mutation Database (HGMD)
WDFY4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDFY4 Gene

Disorders for WDFY4 Gene

Relevant External Links for WDFY4

Genetic Association Database (GAD)
WDFY4
Human Genome Epidemiology (HuGE) Navigator
WDFY4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDFY4
genes like me logo Genes that share disorders with WDFY4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDFY4 Gene

Publications for WDFY4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  2. E26 transformation-specific-1 (ETS1) and WDFY family member 4 (WDFY4) polymorphisms in Chinese patients with rheumatoid arthritis. (PMID: 24549174) Zhang Y. … Liu R. (Int J Mol Sci 2014) 67
  3. Novel Cul3 binding proteins function to remodel E3 ligase complexes. (PMID: 25011449) Wimuttisuk W. … Singer J.D. (BMC Cell Biol. 2014) 67
  4. Genetics of rheumatoid arthritis contributes to biology and drug discovery. (PMID: 24390342) Okada Y. … Plenge R.M. (Nature 2013) 67
  5. Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. (PMID: 23273568) Yang W. … Lau Y.L. (Am. J. Hum. Genet. 2013) 67

Products for WDFY4 Gene

Sources for WDFY4 Gene

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