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Aliases for WDFY4 Gene

Aliases for WDFY4 Gene

  • WDFY Family Member 4 2 3 5
  • C10orf64 3 4
  • Truncated WD Repeat- And FYVE Domain-Containing Protein 4 3
  • WD Repeat- And FYVE Domain-Containing Protein 4 3
  • Chromosome 10 Open Reading Frame 64 2
  • EC 3.6.3.12 58
  • EC 3.5.1.18 58
  • KIAA1607 4

External Ids for WDFY4 Gene

Previous HGNC Symbols for WDFY4 Gene

  • C10orf64

Previous GeneCards Identifiers for WDFY4 Gene

  • GC10P049313
  • GC10U900444
  • GC10P049563
  • GC10P049892
  • GC10P044158

Summaries for WDFY4 Gene

GeneCards Summary for WDFY4 Gene

WDFY4 (WDFY Family Member 4) is a Protein Coding gene. GO annotations related to this gene include binding and phospholipid binding. An important paralog of this gene is WDFY3.

Additional gene information for WDFY4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDFY4 Gene

Genomics for WDFY4 Gene

Regulatory Elements for WDFY4 Gene

Enhancers for WDFY4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H048759 1.1 FANTOM5 Ensembl 15.9 +74.6 74613 0 YBX1 EBF1 BATF RELA EED ATF7 RUNX3 IKZF2 SMARCA5 ZNF687 WDFY4 ARHGAP22 C10orf128 RPL13AP19 LOC105378299
GH10H048748 0.6 ENCODE 16.1 +64.0 64001 0 NR2F1 JUNB EBF1 BCL11A IKZF1 EED IKZF2 RUNX3 SPI1 WDFY4 RPL13AP19 GC10M048627
GH10H048723 0.5 dbSUPER 17 +40.1 40056 3 CEBPB CEBPG REST WDFY4 VSTM4 GC10M048627 RPL13AP19
GH10H048735 0.5 dbSUPER 16 +53.5 53468 6 RFX1 RAD51 POLR2A BHLHE40 USF2 WDFY4 ARHGAP22 RPL13AP19 GC10M048627
GH10H048803 1.2 FANTOM5 ENCODE 5.3 +120.2 120246 3 HDGF PKNOX1 ATF1 TBL1XR1 ZNF766 ELK1 ZNF207 RCOR1 ATF7 RUNX3 WDFY4 LOC105378299 RPL13AP19
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDFY4 on UCSC Golden Path with GeneCards custom track

Promoters for WDFY4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000027810 470 601 HDGF BACH1 MAX BMI1 EBF1 RELA POLR2A EED ATF7 RUNX3

Genomic Location for WDFY4 Gene

Chromosome:
10
Start:
48,684,830 bp from pter
End:
48,982,956 bp from pter
Size:
298,127 bases
Orientation:
Plus strand

Genomic View for WDFY4 Gene

Genes around WDFY4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDFY4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDFY4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDFY4 Gene

Proteins for WDFY4 Gene

  • Protein details for WDFY4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZS81-WDFY4_HUMAN
    Recommended name:
    WD repeat- and FYVE domain-containing protein 4
    Protein Accession:
    Q6ZS81
    Secondary Accessions:
    • B9ZVP2
    • Q86WZ4
    • Q8N4A3
    • Q8TEN7
    • Q96BE1
    • Q9H7H8
    • Q9HCG5

    Protein attributes for WDFY4 Gene

    Size:
    3184 amino acids
    Molecular mass:
    353610 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDFY4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDFY4 Gene

Selected DME Specific Peptides for WDFY4 Gene

Q6ZS81:
  • GQVIGSA
  • STVEGLQ
  • LTFFPAL

Post-translational modifications for WDFY4 Gene

  • Ubiquitination at Lys1317
  • Modification sites at PhosphoSitePlus

Domains & Families for WDFY4 Gene

Gene Families for WDFY4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDFY4: view

No data available for UniProtKB/Swiss-Prot for WDFY4 Gene

Function for WDFY4 Gene

Enzyme Numbers (IUBMB) for WDFY4 Gene

Phenotypes From GWAS Catalog for WDFY4 Gene

Phenotypes for WDFY4 Gene

genes like me logo Genes that share phenotypes with WDFY4: view

Animal Model Products

CRISPR Products

miRNA for WDFY4 Gene

miRTarBase miRNAs that target WDFY4

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WDFY4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDFY4 Gene

Localization for WDFY4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDFY4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDFY4 gene
Compartment Confidence
plasma membrane 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDFY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with WDFY4: view

Pathways & Interactions for WDFY4 Gene

SuperPathways for WDFY4 Gene

No Data Available

Interacting Proteins for WDFY4 Gene

Gene Ontology (GO) - Biological Process for WDFY4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDFY4 Gene

Drugs & Compounds for WDFY4 Gene

No Compound Related Data Available

Transcripts for WDFY4 Gene

mRNA/cDNA for WDFY4 Gene

(11) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WDFY4 Gene

WDFY family member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WDFY4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for WDFY4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^
SP1:
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 46a · 46b ^ 47 ^ 48 ^ 49a · 49b ^ 50 ^ 51 ^ 52 ^ 53 ^ 54a · 54b ^ 55 ^ 56 ^ 57 ^ 58 ^ 59 ^ 60a · 60b ^ 61 ^ 62 ^ 63 ^ 64a · 64b ^ 65 ^ 66a ·
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -

Relevant External Links for WDFY4 Gene

GeneLoc Exon Structure for
WDFY4
ECgene alternative splicing isoforms for
WDFY4

Expression for WDFY4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDFY4 Gene

mRNA differential expression in normal tissues according to GTEx for WDFY4 Gene

This gene is overexpressed in Whole Blood (x7.4) and Spleen (x6.3).

Protein differential expression in normal tissues from HIPED for WDFY4 Gene

This gene is overexpressed in Blymphocyte (21.5), Pancreas (21.3), and Brain (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDFY4 Gene



Protein tissue co-expression partners for WDFY4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDFY4 Gene:

WDFY4

SOURCE GeneReport for Unigene cluster for WDFY4 Gene:

Hs.287379

Evidence on tissue expression from TISSUES for WDFY4 Gene

  • Spleen(4.3)
  • Nervous system(4)
  • Blood(3.8)
genes like me logo Genes that share expression patterns with WDFY4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDFY4 Gene

Orthologs for WDFY4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDFY4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDFY4 33
  • 98.27 (n)
cow
(Bos Taurus)
Mammalia WDFY4 33 34
  • 85.74 (n)
dog
(Canis familiaris)
Mammalia WDFY4 33 34
  • 85.52 (n)
mouse
(Mus musculus)
Mammalia Wdfy4 33 16 34
  • 82.71 (n)
rat
(Rattus norvegicus)
Mammalia Wdfy4 33
  • 81.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDFY4 34
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDFY4 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDFY4 34 33
  • 64.24 (n)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wdfy4 34 33
  • 54.03 (n)
OneToOne
Species where no ortholog for WDFY4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDFY4 Gene

ENSEMBL:
Gene Tree for WDFY4 (if available)
TreeFam:
Gene Tree for WDFY4 (if available)

Paralogs for WDFY4 Gene

Paralogs for WDFY4 Gene

(1) SIMAP similar genes for WDFY4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WDFY4: view

Variants for WDFY4 Gene

Sequence variations from dbSNP and Humsavar for WDFY4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000023381 -- 48,931,463(+) AGGGC(C/T)GTGCT intron-variant
rs1000028419 -- 48,973,845(+) CAAGC(C/T)AAACC intron-variant
rs1000028490 -- 48,770,882(+) CATCA(C/T)GTGCT intron-variant
rs1000035752 -- 48,806,523(+) CCCCT(C/T)CCCCA intron-variant
rs1000042724 -- 48,821,573(+) TGAAC(C/T)TGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDFY4 Gene

Variant ID Type Subtype PubMed ID
dgv232e212 CNV loss 25503493
dgv453n106 CNV deletion 24896259
esv1063968 CNV deletion 17803354
esv1991692 CNV deletion 18987734
esv2472494 CNV deletion 19546169
esv2665419 CNV deletion 23128226
esv2670385 CNV deletion 23128226
esv3262829 CNV deletion 24192839
esv32989 CNV loss 17666407
esv3546252 CNV deletion 23714750
esv3623158 CNV loss 21293372
esv3623159 CNV loss 21293372
esv5318 CNV loss 18987735
esv8160 CNV gain 19470904
esv9654 CNV loss 19470904
esv999945 CNV deletion 20482838
nsv1042677 CNV loss 25217958
nsv1069480 CNV deletion 25765185
nsv1146695 CNV deletion 26484159
nsv512162 CNV loss 21212237
nsv516774 CNV loss 19592680
nsv517287 CNV loss 19592680
nsv523003 CNV loss 19592680
nsv831865 CNV gain 17160897
nsv831866 CNV gain+loss 17160897
nsv947977 CNV duplication 23825009
nsv958222 CNV deletion 24416366
nsv975799 CNV duplication 23825009

Variation tolerance for WDFY4 Gene

Gene Damage Index Score: 15.01; 96.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDFY4 Gene

Human Gene Mutation Database (HGMD)
WDFY4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDFY4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDFY4 Gene

Disorders for WDFY4 Gene

Relevant External Links for WDFY4

Genetic Association Database (GAD)
WDFY4
Human Genome Epidemiology (HuGE) Navigator
WDFY4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDFY4

No disorders were found for WDFY4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDFY4 Gene

Publications for WDFY4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  2. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. (PMID: 22041458) Clark SL … van den Oord EJ (Psychological medicine 2012) 3 45 60
  3. Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus. (PMID: 20169177) Yang W … Asian Lupus Genetics Consortium (PLoS genetics 2010) 3 45 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. (PMID: 19838193) Han JW … Zhang XJ (Nature genetics 2009) 3 45 60

Products for WDFY4 Gene

Sources for WDFY4 Gene

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