Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



WDFY4 Gene

protein-coding   GIFtS: 47
GCID: GC10P049892

WDFY Family Member 4

(Previous name: chromosome 10 open reading frame 64)
(Previous symbol: C10orf64)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
WDFY Family Member 41 2     WD Repeat- And FYVE Domain-Containing Protein 42
C10orf641 2 3     EC 3.5.1.188
KIAA16073 5     EC 3.6.3.128
Chromosome 10 Open Reading Frame 641     

External Ids:    HGNC: 293231   Entrez Gene: 577052   Ensembl: ENSG000001288157   OMIM: 6133165   UniProtKB: Q6ZS813   

Export aliases for WDFY4 gene to outside databases

Previous GC identifers: GC10P049313 GC10U900444 GC10P049563 GC10P044158


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for WDFY4 Gene:
WDFY4 (WDFY family member 4) is a protein-coding gene. Diseases associated with WDFY4 include chediak-higashi syndrome, and systemic lupus erythematosus. An important paralog of this gene is NSMAF.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDFY4 gene promoter:
         AML1a   FOXD3   STAT3   Pax-4a   FOXL1   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for WDFY4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDFY4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.23   Ensembl cytogenetic band:  10q11.22   HGNC cytogenetic band: 10q11.23

WDFY4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDFY4 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P049892:  view genomic region     (about GC identifiers)

Start:
49,892,921 bp from pter      End:
50,191,001 bp from pter
Size:
298,081 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: WDFY4_HUMAN, Q6ZS81 (See protein sequence)
Recommended Name: WD repeat- and FYVE domain-containing protein 4  
Size: 3184 amino acids; 353610 Da
Secondary accessions: B9ZVP2 Q86WZ4 Q8N4A3 Q8TEN7 Q96BE1 Q9H7H8 Q9HCG5
Alternative splicing: 5 isoforms:  Q6ZS81-1   Q6ZS81-2   Q6ZS81-3   Q6ZS81-4   Q6ZS81-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDFY4: NX_Q6ZS81

Explore proteomics data for WDFY4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1317
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for WDFY4 (Q6ZS81)
     GQVIGSA  LTFFPAL  STVEGLQ 


    See WDFY4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065996.1  
    ENSEMBL proteins: 
     ENSP00000354141   ENSP00000363276   ENSP00000265453   ENSP00000320563   ENSP00000403789  

    WDFY4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for WDFY4
    GenScript Custom Purified and Recombinant Proteins Services for WDFY4
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WDFY4

    WDFY4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for WDFY4
    Novus Biologicals WDFY4 Antibody
    Abcam antibodies for WDFY4
    Cloud-Clone Corp. Antibodies for WDFY4
    Search ThermoFisher Antibodies for WDFY4
    Search LSBio for Antibodies for WDFY4

    WDFY4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for WDFY4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WDFY4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WDFY4
    Cloud-Clone Corp. CLIAs for WDFY4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 8):
     IPR000409 BEACH_dom
     IPR011989 ARM-like
     IPR019775 WD40_repeat_CS
     IPR023362 PH-BEACH_dom
     IPR001680 WD40_repeat

    Graphical View of Domain Structure for InterPro Entry Q6ZS81

    ProtoNet protein and cluster: Q6ZS81

    UniProtKB/Swiss-Prot: WDFY4_HUMAN, Q6ZS81
    Similarity: Contains 1 BEACH domain
    Similarity: Contains 5 WD repeats


    WDFY4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Enzyme Numbers (IUBMB): EC 3.6.3.122 EC 3.5.1.182

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    WDFY4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDFY4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WDFY4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WDFY4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WDFY4

    miRNA
    Products:
        
    miRTarBase miRNAs that target WDFY4:
    hsa-mir-335-5p (MIRT018767)

    Block miRNA regulation of human, mouse, rat WDFY4 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate WDFY4:
    hsa-miR-3163 hsa-miR-152 hsa-miR-148b hsa-miR-548u hsa-miR-148a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WDFY4
    Predesigned siRNA for gene silencing in human, mouse, rat WDFY4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WDFY4

    Clone
    Products:
         
    OriGene clones in human, mouse for WDFY4 (see all 6)
    OriGene ORF clones in mouse, rat for WDFY4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WDFY4 (NM_020945)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDFY4
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat WDFY4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for WDFY4
    Browse ESI BIO Cell Lines and PureStem Progenitors for WDFY4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDFY4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    WDFY4_HUMAN, Q6ZS81: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    WDFY4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDFY4
    Interactions:

        Search GeneGlobe Interaction Network for WDFY4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for WDFY4 (ENSP000003205634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AICDAENSP000002293354STRING: ENSP00000229335
    RABGEF1ENSP000002849574STRING: ENSP00000284957
    GGPS1ENSP000002828414STRING: ENSP00000282841
    IFI30ENSP000003848864STRING: ENSP00000384886
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDFY4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for WDFY4 gene: 
    NM_020945.1  

    Unigene Cluster for WDFY4:

    WDFY family member 4
    Hs.287379  [show with all ESTs]
    Unigene Representative Sequence: NM_020945
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360890(uc001jgy.3) ENST00000374161(uc001jhb.1) ENST00000265453(uc009xob.3 uc010qgn.1)
    ENST00000465910 ENST00000497480 ENST00000490507 ENST00000325239(uc001jha.4)
    ENST00000413659

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat WDFY4 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate WDFY4:
    hsa-miR-3163 hsa-miR-152 hsa-miR-148b hsa-miR-548u hsa-miR-148a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WDFY4
    Predesigned siRNA for gene silencing in human, mouse, rat WDFY4
    Clone
    Products:
         
    OriGene clones in human, mouse for WDFY4 (see all 6)
    OriGene ORF clones in mouse, rat for WDFY4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WDFY4 (NM_020945)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDFY4
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat WDFY4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for WDFY4
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat WDFY4
      QuantiTect SYBR Green Assays in human, mouse, rat WDFY4
      QuantiFast Probe-based Assays in human, mouse, rat WDFY4

    Additional mRNA sequence: 

    AB046827.1 AK074085.1 AK074443.1 AK093607.1 AK127650.1 AK301736.1 AL833669.1 BC015694.2 
    BC032420.1 BC034937.1 BC047574.1 

    11 DOTS entries:

    DT.207837  DT.86853800  DT.100746825  DT.99928057  DT.91862719  DT.101958248  DT.97803385  DT.100865949 
    DT.121230791  DT.97814933  DT.40311322 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WDFY4 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                          -                                                                                 
    SP4:                                                                                                                                                            
    SP5:        -                                                                                                                                                   

    ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^
    SP1:                                -                                                                             -                             -               
    SP2:                                                                                                              -                             -               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 46a · 46b ^ 47 ^ 48 ^ 49a · 49b ^ 50 ^ 51 ^ 52 ^ 53 ^ 54a · 54b ^ 55 ^ 56 ^ 57 ^ 58 ^ 59 ^ 60a · 60b ^ 61 ^ 62 ^ 63 ^ 64a · 64b ^ 65 ^ 66a ·
    SP1:                          -                                                                             -                                                   
    SP2:                          -                                                                             -                                                   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for WDFY4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    WDFY4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    WDFY4 Expression
    About this image

    WDFY4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDFY4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.287379
        Custom PCR Arrays for WDFY4
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for WDFY4
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat WDFY4
    QuantiTect SYBR Green Assays in human, mouse, rat WDFY4
    QuantiFast Probe-based Assays in human, mouse, rat WDFY4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDFY4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for WDFY4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdfy41 , 5 WD repeat and FYVE domain containing 41, 5 82.71(n)1
    82.53(a)1
      14 (19.44 cM)5
    5450301  NM_001146022.21  NP_001139494.11 
     329595705 
    chicken
    (Gallus gallus)
    Aves WDFY41 WDFY family member 4 64.24(n)
    59.63(a)
      423781  XM_003641478.2  XP_003641526.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia CD326631.12   -- 73.82(n)    CD326631.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wdfy41 WDFY family member 4 54.03(n)
    44.42(a)
      572477  XM_005156948.1  XP_005157005.1 


    ENSEMBL Gene Tree for WDFY4 (if available)
    TreeFam Gene Tree for WDFY4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for WDFY4 gene
    NSMAF2  LYST2  NBEAL12  LRBA2  NBEA2  WDFY32  NBEAL22  
    1 SIMAP similar gene for WDFY4 using alignment to 5 protein entries:     WDFY4_HUMAN (see all proteins):
    WDFY3

    WDFY4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for WDFY4 (see all 6947)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906054911,2
    --49891593(+) GGTGGA/GCCCTC 1 -- us2k10--------
    rs775758161,2
    C,F--49891728(+) TAATCC/AGCTCT 1 -- us2k14Minor allele frequency- A:0.08NA WA 242
    rs1432645871,2
    --49891731(+) TCCGCC/TCTTAC 1 -- us2k10--------
    rs1505853751,2
    C--49892120(+) GCCTC-/TCA   
       GTCAG
    TCATG
    1 -- us2k10--------
    rs1823261031,2
    --49892138(+) CATGGG/TCCACT 1 -- us2k10--------
    rs727872781,2
    C,F--49892166(+) ACAAGC/AGATGA 1 -- us2k12Minor allele frequency- A:0.12NA EA 240
    rs1856837181,2
    --49892442(+) GGAGGA/TCTCCC 1 -- us2k10--------
    rs2003654931,2
    C--49892445(+) GGACT-/CCCCTCAT 1 -- us2k10--------
    rs1466660371,2
    --49892522(+) GTGGGA/GTGAGG 1 -- us2k10--------
    rs1402118941,2
    --49892545(+) ATGCCA/GTGTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WDFY4 (49892921 - 50142921 bp, first 250kb of WDFY4)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for WDFY4 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736474CNV Deletion23290073
    esv1991692CNV Deletion18987734
    esv2670385CNV Deletion23128226
    esv5318CNV Deletion18987735
    esv999945CNV Deletion20482838
    esv2665419CNV Deletion23128226
    esv1063968CNV Deletion17803354
    esv2472494CNV Deletion19546169
    nsv895365CNV Loss21882294
    esv9654CNV Loss19470904

    Human Gene Mutation Database (HGMD): WDFY4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDFY4
    DNA2.0 Custom Variant and Variant Library Synthesis for WDFY4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 613316    OMIM disorders: --

    5 diseases for WDFY4:    About MalaCards
    chediak-higashi syndrome    systemic lupus erythematosus    lupus erythematosus    atherosclerosis
    alzheimer's disease


    WDFY4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): WDFY4
    Human Genome Epidemiology (HuGE) Navigator: WDFY4 (5 documents)

    Export disorders for WDFY4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for WDFY4 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with WDFY4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. (PubMed id 22041458)1, 4 Clark S.L....van den Oord E.J. (Psychol Med 2012)
    3. Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus. (PubMed id 20169177)1, 4 Yang W....Lau Y.L. (PLoS Genet. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. (PubMed id 19838193)1, 4 Han J.W....Zhang X.J. (Nat. Genet. 2009)
    6. Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. (PubMed id 19165918)1, 4 Graham R.R....Gaffney P.M. (Nat. Genet. 2008)
    7. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PubMed id 17903303)1, 4 O'Donnell C.J....Demissie S. (BMC Med. Genet. 2007)
    8. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57705 HGNC: 29323 Ensembl:ENSG00000128815 euGenes: HUgn57705 ECgene: WDFY4
    H-InvDB: WDFY4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1607

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for WDFY4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for WDFY4 gene:
    Search GeneIP for patents involving WDFY4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for WDFY4  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for WDFY4  
     OriGene qSTAR qPCR primer pairs in human, mouse for WDFY4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for WDFY4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for WDFY4   OriGene Custom Protein Services for WDFY4  

     
     
     Block miRNA regulation of human, mouse, rat WDFY4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing WDFY4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDFY4 Predesigned siRNA for gene silencing in human, mouse, rat WDFY4
     QuantiFast Probe-based Assays in human, mouse, rat WDFY4 QuantiTect SYBR Green Assays in human, mouse, rat WDFY4
     Custom PCR Arrays for WDFY4 Search Chromatin IP Primers for WDFY4
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat WDFY4  Search GeneGlobe Interaction Network for WDFY4
     Regulatory tfbs in WDFY4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for WDFY4 GenScript cDNA clones with any tag delivered in your preferred vector for WDFY4
     GenScript Custom Assay Services for WDFY4 GenScript Custom overexpressing Cell Line Services for WDFY4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for WDFY4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     WDFY4 antibodies
     Antibodies for WDFY4
     See all of Abcam's Antibodies, Kits and Proteins for WDFY4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for WDFY4
     Antibodies for WDFY4
     ELISAs for WDFY4
     CLIAs for WDFY4



     Browse ESI BIO Cell Lines and PureStem Progenitors for WDFY4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDFY4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for WDFY4
     Browse SwitchGear Promoter luciferase reporter plasmids for WDFY4
     Search ThermoFisher Antibodies for WDFY4
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat WDFY4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDFY4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WDFY4
     Search LSBio for Antibodies for WDFY4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      WDFY4 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4