Aliases for WDFY3 Gene
External Ids for WDFY3 Gene
Previous GeneCards Identifiers for WDFY3 Gene
This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]
GeneCards Summary for WDFY3 Gene
WDFY3 (WD Repeat And FYVE Domain Containing 3) is a Protein Coding gene. Diseases associated with WDFY3 include Microcephaly 18, Primary, Autosomal Dominant. GO annotations related to this gene include binding and beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity. An important paralog of this gene is WDFY4.
UniProtKB/Swiss-Prot for WDFY3 Gene
Required for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation.