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Aliases & Descriptions for WDFY3
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ALFY 1 , 2 Alfy 3 KIAA0993 1 , 2 , 3 MGC16461 2 ZFYVE25 1 , 2
Descriptions Autophagy-linked FYVE protein 3 WD repeat and FYVE domain containing 3 2
Search outside databases for aliases for WDFY3 genePrevious GC identifers: GC04M085884 GC04M086049 GC04M085947
Summaries for WDFY3 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for WDFY3 : This gene encodes a protein which contains WD repeats and an FYVE domain. Multiple alternativelyspliced transcript variants have been found for this gene, but the full-length nature of somevariants has not been defined. [provided by RefSeq] Gene Wiki entry for WDFY3
Genomic Location for WDFY3
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the WDFY3 gene Entrez Gene cytogenetic band: 4q21.23 Ensembl cytogenetic band: 4q21.23 HGNC cytogenetic band: 4q21.3 WDFY3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M085809:
(about GC identifiers )
Start:
85,809,719 bp from pter
End:
86,106,568 bp from pter
Size:
296,850 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000004.10 NT_016354.18 Proteins for WDFY3
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: WDFY3_HUMAN, Q8IZQ1 (See
protein sequence )Recommended Name: WD repeat and FYVE domain-containing protein 3 Size : 3526 amino acids; 395258 Da
Subcellular location : Membrane; Peripheral membrane protein; Cytoplasmic side. Note=Co-localizeswith autophagic structures in starved cells
Secondary accessions : Q4W5K5 Q6P0Q5 Q8N1T2 Q8NAV6 Q96BS7 Q96D33 Q96N85 Q9Y2J7Alternative splicing : 4 isoforms : Q8IZQ1-1 Q8IZQ1-2 Q8IZQ1-3 Q8IZQ1-4
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_055806.2 NP_848698.1 NP_848700.1 ENSEMBL proteins: ENSP00000295888 ENSP00000318466 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0016020 membrane
IEA --
About this table Antibodies for WDFY3: Assays for WDFY3:
Protein
Domains/ Families for WDFY3(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q8IZQ1 ProtoNet protein and cluster: Q8IZQ1
2 Blocks protein families : IPB000306 Zn-finger IPB000409 Beige/BEACH domain UniProtKB/Swiss-Prot: WDFY3_HUMAN, Q8IZQ1 Similarity : Contains 1 BEACH domainSimilarity : Contains 1 FYVE-type zinc fingerSimilarity : Contains 2 LRR (leucine-rich) repeatsSimilarity : Contains 5 WD repeats
Gene Function for WDFY3
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_014991 Applied Biosystems Silencer ® siRNAs for WDFY3 Sigma-Aldrich siRNA and siRNA Panels for WDFY3 Sigma-Aldrich shRNA for WDFY3 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_014991                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_014991                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_014991  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014991 3 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for WDFY3
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for WDFY3 (Your Favorite Gene powered by Ingenuity) --
Drugs & Compounds for WDFY3 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for WDFY3
Transcripts for WDFY3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
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shRNA from
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OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_014991 Sigma-Aldrich siRNA and siRNA Panels for WDFY3 Sigma-Aldrich shRNA for WDFY3 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_014991 NM_178583 NM_178585
REFSEQ mRNAs for WDFY3 gene (3 alternative transcripts): NM_014991.4 NM_178583.2 NM_178585.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014991 NM_178583 NM_178585
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_014991                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_014991                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_014991  
Additional cDNA sequence: AB023210.2 AF131845.1 AK055806.1 AK092019.1 AK092394.1 AK094910.1 BC013377.2 BC015214.1 BC065502.1 BC119633.2 BC148294.1 BC148298.2 BC150246.1 BX648077.1 BX648153.1 EF491804.1 EF491819.1
13 DOTS entries : DT.455599 DT.100779276 DT.97808164 DT.95169174 DT.436289 DT.121227189 DT.100779275 DT.95256526 DT.100746625 DT.40265912 DT.40283706 DT.92005579 DT.95215555
24/206 AceView cDNA sequences (see all 206
):AI423502 NM_014991 BQ001670 BF195389 N54129 AA321218 AK094910 BQ960724 AI521819 AL536320 BM987247 BF002955 AA973044 CB215338 AI023914 BC065502 BQ434004 AF131845 BX648077 AW614563 AI554250 BQ024448 BX116506 AI698445
highest scoring ESTs for WDFY3 :BE503740 AI393222 AI962188 AA031778 AA031868 AA149197 AA149198 AA321218 AA635168 AA677526
Unigene Cluster for WDFY3: WD repeat and FYVE domain containing 3 Hs.480116 [show with all ESTs ] Unigene Representative Sequence: NM_014991 GeneLoc Exon Structure 2 Ensembl transcripts including schematic representations : ENST00000295888
ENST00000322366
Expression for WDFY3
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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WDFY3 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for WDFY3 1 / 2 / 3
9 probe-sets matching WDFY3 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: ATTAAATGCASOURCE GeneReport for Unigene cluster: Hs.480116 Expression variation in blood from EXPOLDB for WDFY3
UniProtKB/Swiss-Prot: WDFY3_HUMAN, Q8IZQ1 Tissue specificity : Ubiquitous
Orthologs for WDFY3
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for WDFY3 gene from 5/14 species (see all 14
)
About this table Species with no ortholog for WDFY3 ENSEMBL Gene Tree for WDFY3 Paralogs for WDFY3 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for WDFY3 gene NSMAF 2 LYST 2 WDFY4 2
SNPs/Variants for WDFY3 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for WDFY3 (up to first 250kb)
Disorders & Mutations for WDFY3
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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--
Medical News for WDFY3 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for WDFY3 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/14 PubMed articles for WDFY3 gene (see all 14
): Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032) 2, 3, 4 Nagase T....Ohara O. (1999) Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. (PubMed id 15292400) 3, 4 Simonsen A.... Stenmark H. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954) 3, 4 Nakajima D.... Nagase T. (2002) Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866) 4 Imami K.... Ishihama Y. (2008) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008) Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling. (PubMed id 17053785) 4 Wang Y.... Chen Z. (2006) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 4 Hillier L.W....Wilson R.K. (2005) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002)
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Genome Databases showing WDFY3
(According to
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing WDFY3
(According to HUGE )
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Specialized Databases showing WDFY3 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for WDFY3 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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