WDFY2 Gene
protein-coding GIFtS : 48
GCID: GC13 P052158
WD repeat and FYVE domain containing 2 (Previous name: WD40 and FYVE domain containing 2 )
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Aliasesfor WDFY2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases WD Repeat And FYVE Domain Containing 2 1 2 WD40- And FYVE Domain-Containing Protein 22 3 ZFYVE221 2 3 PROF2 WD40 And FYVE Domain Containing 21 2 RP11-147H23.12 Zinc Finger FYVE Domain-Containing Protein 222 3 Propeller-FYVE Protein2 WDF22 3 WD Repeat And FYVE Domain-Containing Protein 22
Export aliases for WDFY2 gene to outside databases Previous GC identifers: GC13P046146 GC13P051095 GC13P049956 GC13P051056 GC13P032948
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Summariesfor WDFY2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for WDFY2 : This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. (provided by RefSeq, Jul 2008)
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Genomic Viewsfor WDFY2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000013.10 NC_018924.1 NT_024524.14 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the WDFY2 gene promoter: c-Fos AP-1 NRSF form 1 FosB NRSF form 2 Meis-1b GATA-1 Meis-1a c-Jun Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for WDFY2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDFY2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 13q14.3 Ensembl cytogenetic band: 13q14.3 HGNC cytogenetic band: 13q14.12 WDFY2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 13 GeneLoc Exon Structure
GeneLoc location for GC13P052158: view genomic region
(about GC identifiers )
Start:
52,158,484 bp from pter
End:
52,336,171 bp from pter
Size:
177,688 bases
Orientation:
plus strand
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Proteinsfor WDFY2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: WDFY2_HUMAN, Q96P53 (See
protein sequence )Recommended Name: WD repeat and FYVE domain-containing protein 2 Size : 400 amino acids; 45154 Da
Secondary accessions : B1AL86 Q96CS1Explore the universe of human proteins at neXtProt for WDFY2: NX_Q96P53 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96P53 WDFY2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_443182.1 ENSEMBL proteins: ENSP00000298125 Human Recombinant Protein Products: WDFY2 Antibody Products: Assay Products for WDFY2:
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Protein
Domains / Familiesfor WDFY2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
WDFY2 for domains About GeneDecksing 5/9 InterPro domains/families (see all 9 ):
Graphical View of Domain Structure for InterPro Entry Q96P53 ProtoNet protein and cluster: Q96P53
1 Blocks protein family : IPB000306 Zn-finger UniProtKB/Swiss-Prot: WDFY2_HUMAN, Q96P53 Similarity : Contains 1 FYVE-type zinc fingerSimilarity : Contains 7 WD repeats
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Functionfor WDFY2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for WDFY2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for WDFY2 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: WDFY2 (NM_052950 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDFY2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat WDFY2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDFY2
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0046872 metal ion binding
IEA --
WDFY2 for ontologies About GeneDecksing
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Pathways & Interactionsfor WDFY2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WDFY2 STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)4 Interacting proteins for WDFY2 (Q96P53 3 ENSP00000298125 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor WDFY2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for WDFY2 Search CenterWatch for drugs/clinical trials and news about WDFY2
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Transcriptsfor WDFY2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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Primers from
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QIAGEN
)About This Section REFSEQ mRNAs for WDFY2 gene: NM_052950.3 Unigene Cluster for WDFY2:
WD repeat and FYVE domain containing 2 Hs.208550 [show with all ESTs ] Unigene Representative Sequence: NM_052950 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000298125 (uc010ads.1 uc010adt.1 uc001vfp.3 ) ENST00000460145 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for WDFY2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for WDFY2 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: WDFY2 (NM_052950 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDFY2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat WDFY2
Additional cDNA sequence: AF411978.1 AK054833.1 AK058149.1 AK093224.1 AK309815.1 AK311177.1 BC014004.2
17 DOTS entries : DT.312154 DT.95343339
DT.100022742 DT.100660634 DT.100751290 DT.312155 DT.120769969 DT.97816844 DT.40238189 DT.86838664 DT.120769966 DT.120769981 DT.40132095 DT.95370092 DT.99932067 DT.75148371 DT.91927360 24/137 AceView cDNA sequences (see all 137 ):
AI417133 BX363773 BU102054 BM672061 BC014004 BQ574560 BQ888546 BU689194 AI057330 T87542 BU520776 CD358198 BU616176 AA004280 BX099703 BM804744 AI567388 BM987220 AI040673 AA701982 AW614396 AA864300 CB217004 BQ431026 GeneLoc Exon Structure
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Expression for WDFY2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section WDFY2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGCACAGTGG
About this image WDFY2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Heart Left Ventricle Heart Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See WDFY2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for WDFY2 SOURCE GeneReport for Unigene cluster: Hs.208550 SABiosciences Custom PCR Arrays for WDFY2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for WDFY2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat WDFY2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat WDFY2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat WDFY2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDFY2
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Orthologsfor WDFY2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for WDFY2 gene from 6/19 species (see all 19 ) About this table
ENSEMBL Gene Tree for WDFY2 (if available)TreeFam Gene Tree for WDFY2 (if available)
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Paralogsfor WDFY2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for WDFY2 gene WDFY1 2 HGS 2 1 SIMAP similar gene for WDFY2 using alignment to 1 protein entry: WDFY2_HUMAN :WDFY1
WDFY2 for paralogs About GeneDecksing
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Genomic Variantsfor WDFY2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 13 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for WDFY2 (52158484 - 52336171 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for WDFY2 2 CNVs : 35172 4804
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing WDFY2
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Disorders
/ Diseasesfor WDFY2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
WDFY2 for disorders About GeneDecksing
OMIM gene information: 610418
OMIM disorders : --4 diseases for WDFY2 : About MalaCards superior mesenteric artery syndrome enterobiasis typhus tuberculosis 1 disease from the University of Copenhagen DISEASES database for WDFY2 :Typhus Export disorders for WDFY2 gene to outside databases
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Publicationsfor WDFY2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for WDFY2 gene integrated from 9 sources : (articles sorted by number of sources associating them with WDFY2) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. (PubMed id 16873553) 1 , 9 Hayakawa A....Corvera S. (2006) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta. (PubMed id 17313651) 1 Fritzius T....Moelling K. (2007) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. (PubMed id 16792529) 1 Fritzius T....Moelling K. (2006) The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823) 2 Dunham A.... Ross M.T. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000)
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External Searches for WDFY2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing WDFY2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing WDFY2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing WDFY2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for WDFY2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for WDFY2 gene: Search GeneIP for patents involving WDFY2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor WDFY2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for WDFY2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for WDFY2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for WDFY2 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for WDFY2 OriGene 3'-UTR Clone for WDFY2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for WDFY2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for WDFY2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for WDFY2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for WDFY2 OriGene Custom Protein Services for WDFY2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDFY2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing WDFY2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDFY2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat WDFY2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat WDFY2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat WDFY2
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDFY2
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat WDFY2
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