Aliases for WDFY2 Gene
External Ids for WDFY2 Gene
Previous GeneCards Identifiers for WDFY2 Gene
This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008]
GeneCards Summary for WDFY2 Gene
WDFY2 (WD Repeat And FYVE Domain Containing 2) is a Protein Coding gene. Diseases associated with WDFY2 include Balantidiasis and Pulmonary Embolism And Infarction. Among its related pathways are Mesodermal Commitment Pathway. An important paralog of this gene is WDFY1.
UniProtKB/Swiss-Prot for WDFY2 Gene
Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553).