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Aliases for WDFY2 Gene

Aliases for WDFY2 Gene

  • WD Repeat And FYVE Domain Containing 2 2 3 5
  • Zinc Finger FYVE Domain-Containing Protein 22 3 4
  • WD40- And FYVE Domain-Containing Protein 2 3 4
  • WD40 And FYVE Domain Containing 2 2 3
  • Propeller-FYVE Protein 3 4
  • ZFYVE22 3 4
  • PROF 3 4
  • WDF2 3 4

External Ids for WDFY2 Gene

Previous GeneCards Identifiers for WDFY2 Gene

  • GC13P046146
  • GC13P051095
  • GC13P049956
  • GC13P051056
  • GC13P052158
  • GC13P032948

Summaries for WDFY2 Gene

Entrez Gene Summary for WDFY2 Gene

  • This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDFY2 Gene

WDFY2 (WD Repeat And FYVE Domain Containing 2) is a Protein Coding gene. Diseases associated with WDFY2 include Perinephritis and Prolapse Of Female Genital Organ. An important paralog of this gene is HGS.

UniProtKB/Swiss-Prot for WDFY2 Gene

  • Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDFY2 Gene

Genomics for WDFY2 Gene

Regulatory Elements for WDFY2 Gene

Enhancers for WDFY2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDFY2 on UCSC Golden Path with GeneCards custom track

Promoters for WDFY2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDFY2 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDFY2 Gene

Chromosome:
13
Start:
51,584,194 bp from pter
End:
51,767,707 bp from pter
Size:
183,514 bases
Orientation:
Plus strand

Genomic View for WDFY2 Gene

Genes around WDFY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDFY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDFY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDFY2 Gene

Proteins for WDFY2 Gene

  • Protein details for WDFY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P53-WDFY2_HUMAN
    Recommended name:
    WD repeat and FYVE domain-containing protein 2
    Protein Accession:
    Q96P53
    Secondary Accessions:
    • B1AL86
    • Q96CS1

    Protein attributes for WDFY2 Gene

    Size:
    400 amino acids
    Molecular mass:
    45154 Da
    Quaternary structure:
    • Homodimer (PubMed:16792529). Interacts (via WD repeats 1-3) with AKT1, AKT2, PRKCZ and PRKCI (PubMed:16792529). Interacts with VAMP2 (PubMed:17313651). Forms a complex with VAMP2 and PRKCZ (PubMed:17313651). Interacts with FOXO1 (By similarity). Forms a complex with AKT1 and FOXO1 (By similarity).

neXtProt entry for WDFY2 Gene

Proteomics data for WDFY2 Gene at MOPED

Post-translational modifications for WDFY2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDFY2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDFY2 Gene

Domains & Families for WDFY2 Gene

Suggested Antigen Peptide Sequences for WDFY2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96P53

UniProtKB/Swiss-Prot:

WDFY2_HUMAN :
  • The FYVE-type zinc finger is essential for its vesicular localization.
  • Contains 1 FYVE-type zinc finger.
Domain:
  • The FYVE-type zinc finger is essential for its vesicular localization.
Similarity:
  • Contains 1 FYVE-type zinc finger.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDFY2: view

Function for WDFY2 Gene

Molecular function for WDFY2 Gene

UniProtKB/Swiss-Prot Function:
Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553).
genes like me logo Genes that share phenotypes with WDFY2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDFY2 Gene

Localization for WDFY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDFY2 Gene

Endosome. Early endosome. Cytoplasm. Note=Localizes to intracellular vesicles (PubMed:16792529). Colocalizes with VAMP2 and PRKCZ in intracellular vesicles (PubMed:17313651). Colocalizes with AKT2 in early endosomes (By similarity). {ECO:0000250 UniProtKB:Q8BUB4, ECO:0000269 PubMed:16792529, ECO:0000269 PubMed:17313651}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDFY2 Gene COMPARTMENTS Subcellular localization image for WDFY2 gene
Compartment Confidence
endosome 5
cytosol 2
nucleus 2
chloroplast 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for WDFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005769 early endosome IDA 16792529
genes like me logo Genes that share ontologies with WDFY2: view

Pathways & Interactions for WDFY2 Gene

SuperPathways for WDFY2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045600 positive regulation of fat cell differentiation IEA,IMP 18388859
genes like me logo Genes that share ontologies with WDFY2: view

No data available for Pathways by source and SIGNOR curated interactions for WDFY2 Gene

Drugs & Compounds for WDFY2 Gene

(1) Drugs for WDFY2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
methionine sulfoxide Experimental Pharma Target 0
genes like me logo Genes that share compounds with WDFY2: view

Transcripts for WDFY2 Gene

Unigene Clusters for WDFY2 Gene

WD repeat and FYVE domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDFY2 Gene

No ASD Table

Relevant External Links for WDFY2 Gene

GeneLoc Exon Structure for
WDFY2
ECgene alternative splicing isoforms for
WDFY2

Expression for WDFY2 Gene

mRNA expression in normal human tissues for WDFY2 Gene

Protein differential expression in normal tissues from HIPED for WDFY2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.7), NK cells (8.8), Spleen (8.7), Pancreas (6.6), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDFY2 Gene



SOURCE GeneReport for Unigene cluster for WDFY2 Gene Hs.208550

genes like me logo Genes that share expression patterns with WDFY2: view

Protein tissue co-expression partners for WDFY2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDFY2 Gene

Orthologs for WDFY2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDFY2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia WDFY2 35
  • 90.33 (n)
  • 95.3 (a)
WDFY2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdfy2 35
  • 92.5 (n)
  • 98.25 (a)
Wdfy2 16
Wdfy2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDFY2 35
  • 99.67 (n)
  • 99.5 (a)
WDFY2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdfy2 35
  • 91.74 (n)
  • 98.17 (a)
cow
(Bos Taurus)
Mammalia WDFY2 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDFY2 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDFY2 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDFY2 35
  • 84 (n)
  • 92.5 (a)
WDFY2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDFY2 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdfy2 35
  • 78.17 (n)
  • 85.5 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.18512 35
wdfy2 35
  • 75.58 (n)
  • 84.25 (a)
wdfy2 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008932 35
  • 58.54 (n)
  • 54.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5168 35
  • 55.03 (n)
  • 51.01 (a)
CG5168 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea wdfy-2 35
  • 51.12 (n)
  • 42.23 (a)
wdfy-2 36
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS27 36
  • 9 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13448 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4999 36
  • 53 (a)
OneToMany
Species with no ortholog for WDFY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDFY2 Gene

ENSEMBL:
Gene Tree for WDFY2 (if available)
TreeFam:
Gene Tree for WDFY2 (if available)

Paralogs for WDFY2 Gene

Paralogs for WDFY2 Gene

(1) SIMAP similar genes for WDFY2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WDFY2: view

Variants for WDFY2 Gene

Sequence variations from dbSNP and Humsavar for WDFY2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs912097 -- 51,719,396(+) GTTGT(C/T)CTCTT intron-variant
rs715821 -- 51,677,898(+) TTTTG(C/T)GATAT intron-variant
rs992583 -- 51,704,423(+) ATAGT(A/G)TCTGT intron-variant
rs1060562 -- 51,745,542(+) TAGAT(C/T)AGTAA intron-variant
rs1060563 -- 51,745,672(+) CTCAG(A/T)TTATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDFY2 Gene

Variant ID Type Subtype PubMed ID
nsv832612 CNV Gain 17160897
nsv1042 CNV Insertion 18451855

Variation tolerance for WDFY2 Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.70; 57.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WDFY2 Gene

Disorders for WDFY2 Gene

MalaCards: The human disease database

(16) MalaCards diseases for WDFY2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
perinephritis
prolapse of female genital organ
superior mesenteric artery syndrome
  • arteriomesenteric duodenal compression syndrome
enterocele
  • vaginal enterocele
accommodative esotropia
  • esotropia with accommodative compensation
- elite association - COSMIC cancer census association via MalaCards
Search WDFY2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WDFY2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDFY2
genes like me logo Genes that share disorders with WDFY2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDFY2 Gene

Publications for WDFY2 Gene

  1. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. (PMID: 16873553) Hayakawa A. … Corvera S. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. CDKN2D-WDFY2 is a cancer-specific fusion gene recurrent in high-grade serous ovarian carcinoma. (PMID: 24675677) Kannan K. … Yen L. (PLoS Genet. 2014) 3
  5. Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis. (PMID: 18388859) Fritzius T. … Moelling K. (EMBO J. 2008) 3

Products for WDFY2 Gene

Sources for WDFY2 Gene

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