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Aliases for WDFY2 Gene

Aliases for WDFY2 Gene

  • WD Repeat And FYVE Domain Containing 2 2 3
  • Zinc Finger FYVE Domain-Containing Protein 22 3 4
  • WD40- And FYVE Domain-Containing Protein 2 3 4
  • WD40 And FYVE Domain Containing 2 2 3
  • ZFYVE22 3 4
  • WDF2 3 4
  • WD Repeat And FYVE Domain-Containing Protein 2 3
  • Propeller-FYVE Protein 3
  • PROF 3

External Ids for WDFY2 Gene

Previous GeneCards Identifiers for WDFY2 Gene

  • GC13P046146
  • GC13P051095
  • GC13P049956
  • GC13P051056
  • GC13P052158
  • GC13P032948

Summaries for WDFY2 Gene

Entrez Gene Summary for WDFY2 Gene

  • This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDFY2 Gene

WDFY2 (WD Repeat And FYVE Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is WDFY1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDFY2 Gene

Genomics for WDFY2 Gene

Regulatory Elements for WDFY2 Gene

Genomic Location for WDFY2 Gene

51,584,348 bp from pter
51,767,707 bp from pter
183,360 bases
Plus strand

Genomic View for WDFY2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDFY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDFY2 Gene

Proteins for WDFY2 Gene

  • Protein details for WDFY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat and FYVE domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B1AL86
    • Q96CS1

    Protein attributes for WDFY2 Gene

    400 amino acids
    Molecular mass:
    45154 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WDFY2 Gene

Proteomics data for WDFY2 Gene at MOPED

Post-translational modifications for WDFY2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDFY2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for WDFY2 Gene

Domains for WDFY2 Gene

Suggested Antigen Peptide Sequences for WDFY2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 FYVE-type zinc finger.
  • Contains 1 FYVE-type zinc finger.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDFY2: view

Function for WDFY2 Gene

Gene Ontology (GO) - Molecular Function for WDFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with WDFY2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDFY2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDFY2 Gene

Localization for WDFY2 Gene

Subcellular locations from

Jensen Localization Image for WDFY2 Gene COMPARTMENTS Subcellular localization image for WDFY2 gene
Compartment Confidence
cytosol 2
nucleus 2
chloroplast 1
extracellular 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDFY2 Gene

Pathways for WDFY2 Gene

SuperPathways for WDFY2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDFY2 Gene


No data available for Pathways by source for WDFY2 Gene

Drugs for WDFY2 Gene

(1) Drugbank Compounds for WDFY2 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Methionine Sulfoxide
62697-73-8 9577091 Target experimental
genes like me logo Genes that share compounds with WDFY2: view

Transcripts for WDFY2 Gene

Unigene Clusters for WDFY2 Gene

WD repeat and FYVE domain containing 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDFY2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDFY2 Gene

No ASD Table

Relevant External Links for WDFY2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDFY2 Gene

mRNA expression in normal human tissues for WDFY2 Gene

Protein differential expression in normal tissues for WDFY2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.7), NK cells (8.8), Spleen (8.7), Pancreas (6.6), and Testis (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDFY2 Gene

SOURCE GeneReport for Unigene cluster for WDFY2 Gene Hs.208550

genes like me logo Genes that share expressions with WDFY2: view

Expression partners for WDFY2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDFY2 Gene

Orthologs for WDFY2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDFY2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia WDFY2 35
  • 90.33 (n)
  • 95.3 (a)
WDFY2 36
  • 96 (a)
(Mus musculus)
Mammalia Wdfy2 35
  • 92.5 (n)
  • 98.25 (a)
Wdfy2 16
Wdfy2 36
  • 98 (a)
(Pan troglodytes)
Mammalia WDFY2 35
  • 99.67 (n)
  • 99.5 (a)
WDFY2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Wdfy2 35
  • 91.74 (n)
  • 98.17 (a)
(Bos Taurus)
Mammalia WDFY2 36
  • 80 (a)
(Monodelphis domestica)
Mammalia WDFY2 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia WDFY2 36
  • 91 (a)
(Gallus gallus)
Aves WDFY2 35
  • 84 (n)
  • 92.5 (a)
WDFY2 36
  • 93 (a)
(Anolis carolinensis)
Reptilia WDFY2 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdfy2 35
  • 78.17 (n)
  • 85.5 (a)
(Danio rerio)
Actinopterygii Dr.18512 35
wdfy2 35
  • 75.58 (n)
  • 84.25 (a)
wdfy2 36
  • 84 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008932 35
  • 58.54 (n)
  • 54.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5168 35
  • 55.03 (n)
  • 51.01 (a)
CG5168 36
  • 47 (a)
(Caenorhabditis elegans)
Secernentea wdfy-2 35
  • 51.12 (n)
  • 42.23 (a)
wdfy-2 36
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS27 36
  • 9 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13448 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4999 36
  • 53 (a)
Species with no ortholog for WDFY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDFY2 Gene

Gene Tree for WDFY2 (if available)
Gene Tree for WDFY2 (if available)

Paralogs for WDFY2 Gene

Paralogs for WDFY2 Gene

(1) SIMAP similar genes for WDFY2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WDFY2: view

Variants for WDFY2 Gene

Sequence variations from dbSNP and Humsavar for WDFY2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs715821 -- 51,677,898(+) TTTTG(C/T)GATAT intron-variant
rs912097 -- 51,719,396(+) GTTGT(C/T)CTCTT intron-variant
rs992583 -- 51,704,423(+) ATAGT(A/G)TCTGT intron-variant
rs1060562 -- 51,745,542(+) TAGAT(C/T)AGTAA intron-variant
rs1060563 -- 51,745,672(+) CTCAG(A/T)TTATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDFY2 Gene

Variant ID Type Subtype PubMed ID
nsv832612 CNV Gain 17160897
nsv1042 CNV Insertion 18451855

Relevant External Links for WDFY2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDFY2 Gene

Disorders for WDFY2 Gene

(1) University of Copenhagen DISEASES for WDFY2 Gene

genes like me logo Genes that share disorders with WDFY2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for WDFY2 Gene

Publications for WDFY2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. (PMID: 16873553) Hayakawa A. … Corvera S. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 23
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for WDFY2 Gene

Sources for WDFY2 Gene

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