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Aliases for WDFY2 Gene

Aliases for WDFY2 Gene

  • WD Repeat And FYVE Domain Containing 2 2 3
  • Zinc Finger FYVE Domain-Containing Protein 22 3 4
  • WD40- And FYVE Domain-Containing Protein 2 3 4
  • WD40 And FYVE Domain Containing 2 2 3
  • ZFYVE22 3 4
  • WDF2 3 4
  • WD Repeat And FYVE Domain-Containing Protein 2 3
  • Propeller-FYVE Protein 3
  • PROF 3

External Ids for WDFY2 Gene

Summaries for WDFY2 Gene

Entrez Gene Summary for WDFY2 Gene

  • This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDFY2 Gene

WDFY2 (WD Repeat And FYVE Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is WDFY1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDFY2 Gene

Genomics for WDFY2 Gene

Genomic Location for WDFY2 Gene

Start:
51,584,348 bp from pter
End:
51,767,707 bp from pter
Size:
183,360 bases
Orientation:
Plus strand

Genomic View for WDFY2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDFY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDFY2 Gene

Regulatory Elements for WDFY2 Gene

Proteins for WDFY2 Gene

  • Protein details for WDFY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P53-WDFY2_HUMAN
    Recommended name:
    WD repeat and FYVE domain-containing protein 2
    Protein Accession:
    Q96P53
    Secondary Accessions:
    • B1AL86
    • Q96CS1

    Protein attributes for WDFY2 Gene

    Size:
    400 amino acids
    Molecular mass:
    45154 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WDFY2 Gene

Proteomics data for WDFY2 Gene at MOPED

Post-translational modifications for WDFY2 Gene

No Post-translational modifications

Other Protein References for WDFY2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDFY2 Gene

Domains for WDFY2 Gene

Gene Families for WDFY2 Gene

HGNC:
  • ZFYVE :Zinc fingers, FYVE domain containing
  • WDR :WD repeat domain containing

UniProtKB/Swiss-Prot:

WDFY2_HUMAN
Similarity:
  • Contains 1 FYVE-type zinc finger.:
    • Q96P53
  • Contains 7 WD repeats.:
    • Q96P53
genes like me logo Genes that share domains with WDFY2: view

Function for WDFY2 Gene

Gene Ontology (GO) - Molecular Function for WDFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with WDFY2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for WDFY2 Gene

Localization for WDFY2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDFY2 Gene COMPARTMENTS Subcellular localization image for WDFY2 gene
Compartment Confidence
cytosol 2
nucleus 2
chloroplast 1
extracellular 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for WDFY2 Gene

Pathways for WDFY2 Gene

SuperPathways for WDFY2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDFY2 Gene

None

No data available for Pathways by source for WDFY2 Gene

Transcripts for WDFY2 Gene

Unigene Clusters for WDFY2 Gene

WD repeat and FYVE domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDFY2 Gene

No ASD Table

Relevant External Links for WDFY2 Gene

GeneLoc Exon Structure for
WDFY2
ECgene alternative splicing isoforms for
WDFY2

Expression for WDFY2 Gene

mRNA expression in normal human tissues for WDFY2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDFY2 Gene

SOURCE GeneReport for Unigene cluster for WDFY2 Gene Hs.208550

genes like me logo Genes that share expressions with WDFY2: view

Orthologs for WDFY2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDFY2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDFY2 36
  • 99.67 (n)
  • 99.5 (a)
WDFY2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDFY2 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDFY2 36
  • 90.33 (n)
  • 95.3 (a)
WDFY2 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdfy2 36
  • 92.5 (n)
  • 98.25 (a)
Wdfy2 16
Wdfy2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDFY2 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDFY2 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdfy2 36
  • 91.74 (n)
  • 98.17 (a)
chicken
(Gallus gallus)
Aves WDFY2 36
  • 84 (n)
  • 92.5 (a)
WDFY2 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDFY2 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdfy2 36
  • 78.17 (n)
  • 85.5 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.18512 36
wdfy2 36
  • 75.58 (n)
  • 84.25 (a)
wdfy2 37
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008932 36
  • 58.54 (n)
  • 54.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5168 36
  • 55.03 (n)
  • 51.01 (a)
CG5168 37
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea wdfy-2 36
  • 51.12 (n)
  • 42.23 (a)
wdfy-2 37
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS27 37
  • 9 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13448 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4999 37
  • 53 (a)
OneToMany
Species with no ortholog for WDFY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDFY2 Gene

ENSEMBL:
Gene Tree for WDFY2 (if available)
TreeFam:
Gene Tree for WDFY2 (if available)

Paralogs for WDFY2 Gene

Paralogs for WDFY2 Gene

Selected SIMAP similar genes for WDFY2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WDFY2: view

Variants for WDFY2 Gene

Sequence variations from dbSNP and Humsavar for WDFY2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs715821 -- 51,677,898(+) TTTTG(C/T)GATAT intron-variant
rs912097 -- 51,719,396(+) GTTGT(C/T)CTCTT intron-variant
rs992583 -- 51,704,423(+) ATAGT(A/G)TCTGT intron-variant
rs1060562 -- 51,745,542(+) TAGAT(C/T)AGTAA intron-variant
rs1060563 -- 51,745,672(+) CTCAG(A/T)TTATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDFY2 Gene

Variant ID Type Subtype PubMed ID
nsv832612 CNV Gain 17160897
nsv1042 CNV Insertion 18451855

Relevant External Links for WDFY2 Gene

HapMap Linkage Disequilibrium report
WDFY2

Disorders for WDFY2 Gene

(1) University of Copenhagen DISEASES for WDFY2 Gene

genes like me logo Genes that share disorders with WDFY2: view

No data available for UniProtKB/Swiss-Prot for WDFY2 Gene

Publications for WDFY2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. (PMID: 16873553) Hayakawa A. … Corvera S. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 23
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for WDFY2 Gene

Sources for WDFY2 Gene

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