Aliases for WDFY2 Gene
External Ids for WDFY2 Gene
Previous GeneCards Identifiers for WDFY2 Gene
This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008]
GeneCards Summary for WDFY2 Gene
WDFY2 (WD Repeat And FYVE Domain Containing 2) is a Protein Coding gene. Diseases associated with WDFY2 include perinephritis and prolapse of female genital organ. An important paralog of this gene is HGS.
UniProtKB/Swiss-Prot for WDFY2 Gene
Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553).