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Aliases for WDFY1 Gene

Aliases for WDFY1 Gene

  • WD Repeat And FYVE Domain Containing 1 2 3 5
  • Zinc Finger FYVE Domain-Containing Protein 17 3 4
  • WD40- And FYVE Domain-Containing Protein 1 3 4
  • ZFYVE17 3 4
  • FENS-1 3 4
  • WDF1 3 4
  • WD Repeat And FYVE Domain-Containing Protein 1 3
  • Phosphoinositide-Binding Protein SR1 3
  • Phosphoinositide-Binding Protein 1 4
  • WD40 And FYVE Domain Containing 1 2
  • KIAA1435 4

External Ids for WDFY1 Gene

Previous GeneCards Identifiers for WDFY1 Gene

  • GC02M223461
  • GC02M224704
  • GC02M224942
  • GC02M224565
  • GC02M224448
  • GC02M216592

Summaries for WDFY1 Gene

Entrez Gene Summary for WDFY1 Gene

  • The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is mediated by the FYVE domain. [provided by RefSeq, Jan 2015]

GeneCards Summary for WDFY1 Gene

WDFY1 (WD Repeat And FYVE Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include 1-phosphatidylinositol binding. An important paralog of this gene is WDFY2.

UniProtKB/Swiss-Prot for WDFY1 Gene

  • Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDFY1 Gene

Genomics for WDFY1 Gene

Regulatory Elements for WDFY1 Gene

Enhancers for WDFY1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F223893 1.5 FANTOM5 Ensembl ENCODE 22 +49.4 49420 4.8 TBL1XR1 BMI1 EGR1 ZNF366 CBX5 SCRT2 ETV6 FOS CREM ZNF362 WDFY1 MRPL44 GC02P223865
GH02F223886 1.2 FANTOM5 Ensembl ENCODE 24.3 +58.2 58187 0.8 HDGF TFE3 MTA2 EED IKZF1 WDFY1 AP1S3 MRPL44 GC02P223865
GH02F223908 1.6 FANTOM5 Ensembl ENCODE 17.4 +36.6 36589 1.3 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 FOS SP5 WDFY1 GC02P223865
GH02F223796 1.5 FANTOM5 Ensembl ENCODE 10.4 +145.8 145756 6.9 PKNOX1 BMI1 RAD21 YY1 SLC30A9 CBX5 ZNF207 CREM MIXL1 ZNF654 AP1S3 WDFY1 MRPL44 PIR50030
GH02F223464 1.4 FANTOM5 Ensembl ENCODE 7.8 +479.7 479687 1.8 ESRRA JUN MAX ZIC2 RAD21 RFX5 YY1 RCOR1 FOS TCF7L2 WDFY1 LOC105373907 HIGD1AP4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDFY1 on UCSC Golden Path with GeneCards custom track

Promoters for WDFY1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000608367 587 2401 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5

Genomic Location for WDFY1 Gene

Chromosome:
2
Start:
223,855,716 bp from pter
End:
223,945,387 bp from pter
Size:
89,672 bases
Orientation:
Minus strand

Genomic View for WDFY1 Gene

Genes around WDFY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDFY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDFY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDFY1 Gene

Proteins for WDFY1 Gene

  • Protein details for WDFY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWB7-WDFY1_HUMAN
    Recommended name:
    WD repeat and FYVE domain-containing protein 1
    Protein Accession:
    Q8IWB7
    Secondary Accessions:
    • Q53S17
    • Q9H9D5
    • Q9P2B3

    Protein attributes for WDFY1 Gene

    Size:
    410 amino acids
    Molecular mass:
    46324 Da
    Quaternary structure:
    • Binds PtdIns3P in vitro with high specificity over other phosphoinositides. Interacts (via WD repeat 2) with tyrosine-phosphorylated TLR3 (via TIR domain) in response to poly(I:C) (PubMed:25736436). Interacts with TICAM1 in response to poly(I:C) (By similarity). Interacts with TLR4 in response to LPS (By similarity).
    SequenceCaution:
    • Sequence=BAA92673.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for WDFY1 Gene

Post-translational modifications for WDFY1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDFY1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDFY1 Gene

Domains & Families for WDFY1 Gene

Suggested Antigen Peptide Sequences for WDFY1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWB7

UniProtKB/Swiss-Prot:

WDFY1_HUMAN :
  • The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions. The FYVE domain is required for its function in regulating TLR3 signaling (PubMed:25736436).
  • Contains 1 FYVE-type zinc finger.
Domain:
  • The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions. The FYVE domain is required for its function in regulating TLR3 signaling (PubMed:25736436).
Similarity:
  • Contains 1 FYVE-type zinc finger.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDFY1: view

Function for WDFY1 Gene

Molecular function for WDFY1 Gene

UniProtKB/Swiss-Prot Function:
Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436).

Gene Ontology (GO) - Molecular Function for WDFY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25736436
GO:0005545 1-phosphatidylinositol binding IDA 11739631
GO:0008270 zinc ion binding NAS 11739631
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with WDFY1: view
genes like me logo Genes that share phenotypes with WDFY1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDFY1 Gene

Localization for WDFY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDFY1 Gene

Early endosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDFY1 gene
Compartment Confidence
nucleus 5
cytosol 5
endosome 5
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for WDFY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11739631
GO:0005768 endosome IEA --
GO:0005769 early endosome IDA 11739631
GO:0005829 cytosol IDA 11739631
genes like me logo Genes that share ontologies with WDFY1: view

Pathways & Interactions for WDFY1 Gene

SuperPathways for WDFY1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDFY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway IMP 25736436
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway IMP 25736436
genes like me logo Genes that share ontologies with WDFY1: view

No data available for Pathways by source and SIGNOR curated interactions for WDFY1 Gene

Transcripts for WDFY1 Gene

Unigene Clusters for WDFY1 Gene

WD repeat and FYVE domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDFY1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - - - -
SP3:
SP4: -
SP5:

Relevant External Links for WDFY1 Gene

GeneLoc Exon Structure for
WDFY1
ECgene alternative splicing isoforms for
WDFY1

Expression for WDFY1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDFY1 Gene

Protein differential expression in normal tissues from HIPED for WDFY1 Gene

This gene is overexpressed in Urinary Bladder (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDFY1 Gene



Protein tissue co-expression partners for WDFY1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDFY1 Gene:

WDFY1

SOURCE GeneReport for Unigene cluster for WDFY1 Gene:

Hs.368359
genes like me logo Genes that share expression patterns with WDFY1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDFY1 Gene

Orthologs for WDFY1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDFY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDFY1 34 35
  • 99.27 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDFY1 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDFY1 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDFY1 34 35
  • 90.98 (n)
dog
(Canis familiaris)
Mammalia WDFY1 34 35
  • 89.35 (n)
mouse
(Mus musculus)
Mammalia Wdfy1 34 16 35
  • 88.86 (n)
chicken
(Gallus gallus)
Aves WDFY1 34 35
  • 81.78 (n)
lizard
(Anolis carolinensis)
Reptilia WDFY1 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdfy1 34
  • 73.12 (n)
Str.11442 34
zebrafish
(Danio rerio)
Actinopterygii wdfy1 34 35
  • 75.16 (n)
Dr.3787 34
fruit fly
(Drosophila melanogaster)
Insecta CG5168 35
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea wdfy-2 35
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS27 35
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4999 35
  • 51 (a)
OneToMany
Species where no ortholog for WDFY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDFY1 Gene

ENSEMBL:
Gene Tree for WDFY1 (if available)
TreeFam:
Gene Tree for WDFY1 (if available)

Paralogs for WDFY1 Gene

Paralogs for WDFY1 Gene

(1) SIMAP similar genes for WDFY1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WDFY1: view

Variants for WDFY1 Gene

Sequence variations from dbSNP and Humsavar for WDFY1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10171599 -- 223,901,855(+) CTTTT(A/T)ATCAG intron-variant
rs10174705 -- 223,934,213(+) cctac(A/C)gagta intron-variant
rs10177718 -- 223,931,690(+) TCTTT(C/T)TTTTT intron-variant
rs10186716 -- 223,881,079(+) GAAAA(A/T)AGTGG intron-variant
rs10187115 -- 223,934,088(+) ttttt(C/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDFY1 Gene

Variant ID Type Subtype PubMed ID
nsv214769 CNV deletion 16902084
nsv834555 CNV loss 17160897

Variation tolerance for WDFY1 Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDFY1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDFY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDFY1 Gene

Disorders for WDFY1 Gene

Relevant External Links for WDFY1

Genetic Association Database (GAD)
WDFY1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDFY1

No disorders were found for WDFY1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDFY1 Gene

Publications for WDFY1 Gene

  1. FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. (PMID: 11739631) Ridley S.H. … Hawkins P.T. (J. Cell Sci. 2001) 2 3 4 64
  2. WDFY1 mediates TLR3/4 signaling by recruiting TRIF. (PMID: 25736436) Hu Y.H. … Liu Y. (EMBO Rep. 2015) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64

Products for WDFY1 Gene

Sources for WDFY1 Gene

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