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Aliases & Descriptions for WDFY1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FENS-1 1, 2, 3 | | KIAA1435 1, 3 | | WDF1 1, 2, 3 | | ZFYVE17 1, 2, 3 |
| | | Descriptions |
|---|
| Phosphoinositide-binding protein 1 3 | | WD repeat and FYVE domain containing 1 2 | | WD40 and FYVE domain containing 1 1, 2 | | WD40- and FYVE domain-containing protein 1 3 | | Zinc finger FYVE domain-containing protein 17 3 | | phosphoinositide-binding protein SR1 2 |
|
| | Search outside databases for aliases for WDFY1 genePrevious GC identifers: GC02M223461 GC02M224704 GC02M224942 GC02M224565 |
Summaries for WDFY1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for WDFY1: The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. This gene encodes a protein which contains a single FYVE domain and multiple WD40 repeats. This protein is localized to endosomes. [provided by RefSeq]
|
Genomic Location for WDFY1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the WDFY1 gene 
Entrez Gene cytogenetic band: 2q36.1 Ensembl cytogenetic band: 2q36.1 HGNC cytogenetic band: 2q36.2WDFY1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M224448:
(about GC identifiers)
Start:
|
224,448,309 bp from pter |
End:
|
224,518,296 bp from pter |
Size:
|
69,988 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000002.10 NT_005403.16
| Proteins for WDFY1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: WDFY1_HUMAN, Q8IWB7 (See
protein sequence)Recommended Name: WD repeat and FYVE domain-containing protein 1 Size: 410 amino acids; 46324 Da
Subunit: Binds PtdIns3P in vitro with high specificity over other phosphoinositides
Subcellular location: Early endosome
Secondary accessions: Q9H9D5 Q9P2B3Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_065881.1
ENSEMBL proteins: ENSP00000233055 ENSP00000272881
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: WDFY1 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for WDFY1: Assays for WDFY1: | Protein
Domains/ Families for WDFY1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8IWB7
ProtoNet protein and cluster: Q8IWB7 1 Blocks protein family: IPB000306 Zn-finger
UniProtKB/Swiss-Prot: WDFY1_HUMAN, Q8IWB7Similarity: Contains 1 FYVE-type zinc fingerSimilarity: Contains 7 WD repeats | Gene Function for WDFY1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_020830
Applied Biosystems Silencer® siRNAs for WDFY1
Sigma-Aldrich siRNA for WDFY1  Sigma-Aldrich shRNA for WDFY1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020830                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020830                                  untagged cDNA clones in CMV expression vector (see all 2): NM_020830 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_020830
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for WDFY1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | About this table
|
Drugs & Compounds for WDFY1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for WDFY1
|
Transcripts for WDFY1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_020830
Sigma-Aldrich siRNA for WDFY1  Sigma-Aldrich shRNA for WDFY1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_020830 REFSEQ mRNAs for WDFY1 gene: NM_020830.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_020830               OriGene GFP tagged cDNA clone in CMV expression vector: NM_020830                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020830                                  untagged cDNA clones in CMV expression vector (see all 2): NM_020830  Additional cDNA sequence: AB037856.1 AF411977.1 AJ310568.1 AK022888.1 AK023415.1 BC040525.1 BC065934.1 7 DOTS entries: DT.415418 DT.91770521 DT.95150414 DT.100027471 DT.120940389 DT.91770519 DT.100034723 24/276 AceView cDNA sequences (see all 276
):AF411977 AA450337 BG177582 BF447259 AA721432 BG759326 AW070738 AA411290 AW243572 BG109779 CA398252 CD171698 BU167040 BM470844 BG119034 BM541399 AK023415 BM786152 NM_020830 BP364649 AA406307 BM692877 BF223120 BX115673
highest scoring ESTs for WDFY1:AB037856 AF411977 AI695418 AJ310568 AK022888 AL036048 AW963897 BC040525 BC065934 BE262784 Unigene Cluster for WDFY1: WD repeat and FYVE domain containing 1 Hs.708107 [show with all ESTs]Unigene Representative Sequence: BC040525
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for WDFY1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | - |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for WDFY1
2 Ensembl transcripts including schematic representations: ENST00000233055
ENST00000352510
|
Expression for WDFY1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| WDFY1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for WDFY1
1 / 2 / 3 6 probe-sets matching WDFY1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTATATTTAT
SOURCE GeneReport for Unigene cluster: Hs.708107
|
Orthologs for WDFY1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for WDFY1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for WDFY1
ENSEMBL Gene Tree for WDFY1 | Paralogs for WDFY1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for WDFY1 gene
- WDFY22
|
SNPs/Variants for WDFY1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for WDFY1 (up to first 250kb)
|
Disorders & Mutations for WDFY1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for WDFY1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for WDFY1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 5 PubMed articles for WDFY1 gene: |
Search for WDFY1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing WDFY1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing WDFY1
(According to HUGE)
About This Section
| |
Specialized Databases showing WDFY1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for WDFY1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for WDFY1:

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| | | | Search Tocris compounds for WDFY1 |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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