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Aliases for WDFY1 Gene

Aliases for WDFY1 Gene

  • WD Repeat And FYVE Domain Containing 1 2 3
  • Zinc Finger FYVE Domain-Containing Protein 17 3 4
  • WD40- And FYVE Domain-Containing Protein 1 3 4
  • ZFYVE17 3 4
  • FENS-1 3 4
  • WDF1 3 4
  • WD Repeat And FYVE Domain-Containing Protein 1 3
  • Phosphoinositide-Binding Protein SR1 3
  • Phosphoinositide-Binding Protein 1 4
  • WD40 And FYVE Domain Containing 1 2
  • KIAA1435 4

External Ids for WDFY1 Gene

Summaries for WDFY1 Gene

Entrez Gene Summary for WDFY1 Gene

  • The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is mediated by the FYVE domain. [provided by RefSeq, Jan 2015]

GeneCards Summary for WDFY1 Gene

WDFY1 (WD Repeat And FYVE Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include 1-phosphatidylinositol binding. An important paralog of this gene is HGS.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDFY1 Gene

Genomics for WDFY1 Gene

Genomic Location for WDFY1 Gene

Start:
223,855,716 bp from pter
End:
223,945,387 bp from pter
Size:
89,672 bases
Orientation:
Minus strand

Genomic View for WDFY1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDFY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDFY1 Gene

Regulatory Elements for WDFY1 Gene

Proteins for WDFY1 Gene

  • Protein details for WDFY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWB7-WDFY1_HUMAN
    Recommended name:
    WD repeat and FYVE domain-containing protein 1
    Protein Accession:
    Q8IWB7
    Secondary Accessions:
    • Q53S17
    • Q9H9D5
    • Q9P2B3

    Protein attributes for WDFY1 Gene

    Size:
    410 amino acids
    Molecular mass:
    46324 Da
    Quaternary structure:
    • Binds PtdIns3P in vitro with high specificity over other phosphoinositides
    SequenceCaution:
    • Sequence=BAA92673.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WDFY1 Gene

Proteomics data for WDFY1 Gene at MOPED

Post-translational modifications for WDFY1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDFY1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDFY1 Gene

Domains for WDFY1 Gene

Gene Families for WDFY1 Gene

HGNC:
  • ZFYVE :Zinc fingers, FYVE domain containing
  • WDR :WD repeat domain containing

UniProtKB/Swiss-Prot:

WDFY1_HUMAN
Domain:
  • The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions.:
    • Q8IWB7
Similarity:
  • Contains 1 FYVE-type zinc finger.:
    • Q8IWB7
  • Contains 7 WD repeats.:
    • Q8IWB7
genes like me logo Genes that share domains with WDFY1: view

Function for WDFY1 Gene

Gene Ontology (GO) - Molecular Function for WDFY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005545 1-phosphatidylinositol binding IDA 11739631
GO:0008270 zinc ion binding NAS 11739631
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with WDFY1: view

miRNA for WDFY1 Gene

miRTarBase miRNAs that target WDFY1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDFY1 Gene

Localization for WDFY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDFY1 Gene

Early endosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDFY1 Gene COMPARTMENTS Subcellular localization image for WDFY1 gene
Compartment Confidence
cytosol 5
endosome 5
nucleus 5
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for WDFY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11739631
GO:0005769 early endosome IDA 11739631
GO:0005829 cytosol IDA 11739631
genes like me logo Genes that share ontologies with WDFY1: view

Pathways for WDFY1 Gene

SuperPathways for WDFY1 Gene

No Data Available

Interacting Proteins for WDFY1 Gene

Gene Ontology (GO) - Biological Process for WDFY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with WDFY1: view

No data available for Pathways by source for WDFY1 Gene

Transcripts for WDFY1 Gene

Unigene Clusters for WDFY1 Gene

WD repeat and FYVE domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDFY1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - - - -
SP3:
SP4: -
SP5:

Relevant External Links for WDFY1 Gene

GeneLoc Exon Structure for
WDFY1
ECgene alternative splicing isoforms for
WDFY1

Expression for WDFY1 Gene

mRNA expression in normal human tissues for WDFY1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDFY1 Gene

SOURCE GeneReport for Unigene cluster for WDFY1 Gene Hs.368359

genes like me logo Genes that share expressions with WDFY1: view

Orthologs for WDFY1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDFY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDFY1 36
  • 99.27 (n)
  • 99.51 (a)
WDFY1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDFY1 36
  • 90.98 (n)
  • 97.8 (a)
WDFY1 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDFY1 36
  • 89.35 (n)
  • 97.8 (a)
WDFY1 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdfy1 36
  • 88.86 (n)
  • 97.8 (a)
Wdfy1 16
Wdfy1 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDFY1 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDFY1 37
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDFY1 36
  • 81.78 (n)
  • 91.91 (a)
WDFY1 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDFY1 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11442 36
wdfy1 36
  • 73.12 (n)
  • 81.62 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.3787 36
wdfy1 36
  • 75.16 (n)
  • 80.15 (a)
wdfy1 37
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5168 37
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea wdfy-2 37
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS27 37
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4999 37
  • 51 (a)
OneToMany
Species with no ortholog for WDFY1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDFY1 Gene

ENSEMBL:
Gene Tree for WDFY1 (if available)
TreeFam:
Gene Tree for WDFY1 (if available)

Paralogs for WDFY1 Gene

Paralogs for WDFY1 Gene

Selected SIMAP similar genes for WDFY1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WDFY1: view

Variants for WDFY1 Gene

Sequence variations from dbSNP and Humsavar for WDFY1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs9795 -- 223,877,328(+) ATATC(C/T)ATTAG utr-variant-3-prime
rs12815 -- 223,877,644(+) ACTAA(A/C)TTCTT utr-variant-3-prime
rs172187 -- 223,897,591(-) accag(A/C)ctggc intron-variant
rs187301 -- 223,897,517(-) ctgta(A/G)tccca intron-variant
rs190733 -- 223,897,435(-) tgcca(C/T)tgcac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDFY1 Gene

Variant ID Type Subtype PubMed ID
nsv834555 CNV Loss 17160897
nsv214769 CNV Loss 16902084
nsv875897 CNV Gain 21882294

Relevant External Links for WDFY1 Gene

HapMap Linkage Disequilibrium report
WDFY1

Disorders for WDFY1 Gene

Relevant External Links for WDFY1

Genetic Association Database (GAD)
WDFY1
genes like me logo Genes that share disorders with WDFY1: view

No data available for UniProtKB/Swiss-Prot for WDFY1 Gene

Publications for WDFY1 Gene

  1. FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. (PMID: 11739631) Ridley S.H. … Hawkins P.T. (J. Cell Sci. 2001) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for WDFY1 Gene

Sources for WDFY1 Gene

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