Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDFY1 Gene

Aliases for WDFY1 Gene

  • WD Repeat And FYVE Domain Containing 1 2 3
  • Zinc Finger FYVE Domain-Containing Protein 17 3 4
  • WD40- And FYVE Domain-Containing Protein 1 3 4
  • ZFYVE17 3 4
  • FENS-1 3 4
  • WDF1 3 4
  • Phosphoinositide-Binding Protein SR1 3
  • Phosphoinositide-Binding Protein 1 4
  • WD40 And FYVE Domain Containing 1 2
  • KIAA1435 4

External Ids for WDFY1 Gene

Previous GeneCards Identifiers for WDFY1 Gene

  • GC02M223461
  • GC02M224704
  • GC02M224942
  • GC02M224565
  • GC02M224448
  • GC02M216592

Summaries for WDFY1 Gene

Entrez Gene Summary for WDFY1 Gene

  • The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is mediated by the FYVE domain. [provided by RefSeq, Jan 2015]

GeneCards Summary for WDFY1 Gene

WDFY1 (WD Repeat And FYVE Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include 1-phosphatidylinositol binding. An important paralog of this gene is HGS.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDFY1 Gene

Genomics for WDFY1 Gene

Regulatory Elements for WDFY1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WDFY1 Gene

Chromosome:
2
Start:
223,855,716 bp from pter
End:
223,945,387 bp from pter
Size:
89,672 bases
Orientation:
Minus strand

Genomic View for WDFY1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDFY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDFY1 Gene

Proteins for WDFY1 Gene

  • Protein details for WDFY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWB7-WDFY1_HUMAN
    Recommended name:
    WD repeat and FYVE domain-containing protein 1
    Protein Accession:
    Q8IWB7
    Secondary Accessions:
    • Q53S17
    • Q9H9D5
    • Q9P2B3

    Protein attributes for WDFY1 Gene

    Size:
    410 amino acids
    Molecular mass:
    46324 Da
    Quaternary structure:
    • Binds PtdIns3P in vitro with high specificity over other phosphoinositides
    SequenceCaution:
    • Sequence=BAA92673.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WDFY1 Gene

Proteomics data for WDFY1 Gene at MOPED

Post-translational modifications for WDFY1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDFY1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for WDFY1 Gene

Domains & Families for WDFY1 Gene

Suggested Antigen Peptide Sequences for WDFY1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWB7

UniProtKB/Swiss-Prot:

WDFY1_HUMAN :
  • The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions.
  • Contains 1 FYVE-type zinc finger.
Domain:
  • The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions.
Similarity:
  • Contains 1 FYVE-type zinc finger.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDFY1: view

Function for WDFY1 Gene

Gene Ontology (GO) - Molecular Function for WDFY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25736436
GO:0005545 1-phosphatidylinositol binding IDA 11739631
GO:0008270 zinc ion binding NAS 11739631
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with WDFY1: view

Phenotypes for WDFY1 Gene

GenomeRNAi human phenotypes for WDFY1:
genes like me logo Genes that share phenotypes with WDFY1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDFY1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for WDFY1 Gene

Localization for WDFY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDFY1 Gene

Early endosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDFY1 Gene COMPARTMENTS Subcellular localization image for WDFY1 gene
Compartment Confidence
cytosol 5
endosome 5
nucleus 5

Gene Ontology (GO) - Cellular Components for WDFY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11739631
GO:0005769 early endosome IDA 11739631
GO:0005829 cytosol IDA 11739631
genes like me logo Genes that share ontologies with WDFY1: view

Pathways & Interactions for WDFY1 Gene

SuperPathways for WDFY1 Gene

No Data Available

Interacting Proteins for WDFY1 Gene

Gene Ontology (GO) - Biological Process for WDFY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway IMP 25736436
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway IMP 25736436
genes like me logo Genes that share ontologies with WDFY1: view

No data available for Pathways by source and SIGNOR curated interactions for WDFY1 Gene

Drugs & Compounds for WDFY1 Gene

No Compound Related Data Available

Transcripts for WDFY1 Gene

Unigene Clusters for WDFY1 Gene

WD repeat and FYVE domain containing 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDFY1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDFY1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - - - -
SP3:
SP4: -
SP5:

Relevant External Links for WDFY1 Gene

GeneLoc Exon Structure for
WDFY1
ECgene alternative splicing isoforms for
WDFY1

Expression for WDFY1 Gene

mRNA expression in normal human tissues for WDFY1 Gene

Protein differential expression in normal tissues from HIPED for WDFY1 Gene

This gene is overexpressed in Urinary Bladder (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDFY1 Gene



SOURCE GeneReport for Unigene cluster for WDFY1 Gene Hs.368359

genes like me logo Genes that share expression patterns with WDFY1: view

Protein tissue co-expression partners for WDFY1 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDFY1 Gene

Orthologs for WDFY1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDFY1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDFY1 35
  • 90.98 (n)
  • 97.8 (a)
WDFY1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDFY1 35
  • 89.35 (n)
  • 97.8 (a)
WDFY1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdfy1 35
  • 88.86 (n)
  • 97.8 (a)
Wdfy1 16
Wdfy1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDFY1 35
  • 99.27 (n)
  • 99.51 (a)
WDFY1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDFY1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDFY1 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDFY1 35
  • 81.78 (n)
  • 91.91 (a)
WDFY1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDFY1 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11442 35
wdfy1 35
  • 73.12 (n)
  • 81.62 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.3787 35
wdfy1 35
  • 75.16 (n)
  • 80.15 (a)
wdfy1 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5168 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea wdfy-2 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS27 36
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4999 36
  • 51 (a)
OneToMany
Species with no ortholog for WDFY1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDFY1 Gene

ENSEMBL:
Gene Tree for WDFY1 (if available)
TreeFam:
Gene Tree for WDFY1 (if available)

Paralogs for WDFY1 Gene

Paralogs for WDFY1 Gene

(1) SIMAP similar genes for WDFY1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WDFY1: view

Variants for WDFY1 Gene

Sequence variations from dbSNP and Humsavar for WDFY1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs9795 -- 223,877,328(+) ATATC(C/T)ATTAG utr-variant-3-prime
rs12815 -- 223,877,644(+) ACTAA(A/C)TTCTT utr-variant-3-prime
rs172187 -- 223,897,591(-) accag(A/C)ctggc intron-variant
rs187301 -- 223,897,517(-) ctgta(A/G)tccca intron-variant
rs190733 -- 223,897,435(-) tgcca(C/T)tgcac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDFY1 Gene

Variant ID Type Subtype PubMed ID
nsv834555 CNV Loss 17160897
nsv214769 CNV Loss 16902084
nsv875897 CNV Gain 21882294

Variation tolerance for WDFY1 Gene

Residual Variation Intolerance Score: 32.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDFY1 Gene

HapMap Linkage Disequilibrium report
WDFY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDFY1 Gene

Disorders for WDFY1 Gene

Relevant External Links for WDFY1

Genetic Association Database (GAD)
WDFY1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDFY1
genes like me logo Genes that share disorders with WDFY1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDFY1 Gene

Publications for WDFY1 Gene

  1. FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. (PMID: 11739631) Ridley S.H. … Hawkins P.T. (J. Cell Sci. 2001) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  4. WDFY1 mediates TLR3/4 signaling by recruiting TRIF. (PMID: 25736436) Hu Y.H. … Liu Y. (EMBO Rep. 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for WDFY1 Gene

Sources for WDFY1 Gene

Back to Top

Content