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Aliases for WDCP Gene

Aliases for WDCP Gene

  • WD Repeat And Coiled Coil Containing 2 3 5
  • C2orf44 3 4
  • WD Repeat And Coiled-Coil-Containing Protein C2orf44 3
  • WD Repeat And Coiled-Coil-Containing Protein 3
  • WD Repeat-Containing Protein C2orf44 3
  • Chromosome 2 Open Reading Frame 44 2
  • PP384 3

External Ids for WDCP Gene

Previous HGNC Symbols for WDCP Gene

  • C2orf44

Summaries for WDCP Gene

GeneCards Summary for WDCP Gene

WDCP (WD Repeat And Coiled Coil Containing) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDCP Gene

Genomics for WDCP Gene

Regulatory Elements for WDCP Gene

Enhancers for WDCP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around WDCP on UCSC Golden Path with GeneCards custom track

Promoters for WDCP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for WDCP Gene

24,029,336 bp from pter
24,049,575 bp from pter
20,240 bases
Minus strand

Genomic View for WDCP Gene

Genes around WDCP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDCP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDCP Gene

Proteins for WDCP Gene

  • Protein details for WDCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat and coiled-coil-containing protein
    Protein Accession:
    Secondary Accessions:
    • D6W532
    • Q8IYK0
    • Q9HBP5

    Protein attributes for WDCP Gene

    721 amino acids
    Molecular mass:
    79136 Da
    Quaternary structure:
    • Oligomer. Interacts with HCK (via SH3 domain).

    Alternative splice isoforms for WDCP Gene


neXtProt entry for WDCP Gene

Post-translational modifications for WDCP Gene

Other Protein References for WDCP Gene

No data available for DME Specific Peptides for WDCP Gene

Domains & Families for WDCP Gene

Protein Domains for WDCP Gene


Suggested Antigen Peptide Sequences for WDCP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 WD repeats.
  • Contains 2 WD repeats.
genes like me logo Genes that share domains with WDCP: view

No data available for Gene Families for WDCP Gene

Function for WDCP Gene

Gene Ontology (GO) - Molecular Function for WDCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019900 kinase binding IPI 25469238
genes like me logo Genes that share ontologies with WDCP: view

Phenotypes for WDCP Gene

genes like me logo Genes that share phenotypes with WDCP: view

Animal Model Products

miRNA for WDCP Gene

miRTarBase miRNAs that target WDCP

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDCP Gene

Localization for WDCP Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for WDCP Gene

Pathways & Interactions for WDCP Gene

SuperPathways for WDCP Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051259 protein oligomerization IDA 25469238
genes like me logo Genes that share ontologies with WDCP: view

No data available for Pathways by source and SIGNOR curated interactions for WDCP Gene

Drugs & Compounds for WDCP Gene

No Compound Related Data Available

Transcripts for WDCP Gene

mRNA/cDNA for WDCP Gene

Unigene Clusters for WDCP Gene

Chromosome 2 open reading frame 44:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDCP Gene

No ASD Table

Relevant External Links for WDCP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDCP Gene

NURSA nuclear receptor signaling pathways regulating expression of WDCP Gene:


SOURCE GeneReport for Unigene cluster for WDCP Gene:

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for WDCP Gene

Orthologs for WDCP Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDCP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C11H2orf44 34
  • 81.37 (n)
  • 75.71 (a)
C2orf44 35
  • 74 (a)
(Canis familiaris)
Mammalia C17H2orf44 34
  • 81.85 (n)
  • 74.16 (a)
C2orf44 35
  • 71 (a)
(Mus musculus)
Mammalia BC068281 34
  • 74.93 (n)
  • 66.98 (a)
BC068281 16
BC068281 35
  • 64 (a)
(Pan troglodytes)
Mammalia C2AH2orf44 34
  • 99.4 (n)
  • 98.89 (a)
C2orf44 35
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1563701 34
  • 74.3 (n)
  • 64.04 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 55 (a)
-- 35
  • 44 (a)
-- 35
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia C2orf44 35
  • 47 (a)
(Gallus gallus)
Aves LOC421975 34
  • 60.55 (n)
  • 52.87 (a)
C2orf44 35
  • 47 (a)
(Anolis carolinensis)
Reptilia C2orf44 35
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c2orf44 34
  • 57.55 (n)
  • 53.49 (a)
(Danio rerio)
Actinopterygii zgc:103511 34
  • 54.6 (n)
  • 50.54 (a)
C20H2orf44 35
  • 43 (a)
Species where no ortholog for WDCP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDCP Gene

Gene Tree for WDCP (if available)
Gene Tree for WDCP (if available)

Paralogs for WDCP Gene

No data available for Paralogs for WDCP Gene

Variants for WDCP Gene

Sequence variations from dbSNP and Humsavar for WDCP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3731620 - 24,039,190(-) GCTGA(C/T)GTCTC reference, missense
VAR_035876 A breast cancer sample
rs3203 -- 24,029,547(+) GTCAC(C/G/T)GCTCT utr-variant-3-prime
rs3204 -- 24,029,566(+) TGATT(A/G)CAGAC utr-variant-3-prime
rs2339939 -- 24,029,079(-) GGAGA(A/G)AAGAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for WDCP Gene

Variant ID Type Subtype PubMed ID
esv3553800 CNV deletion 23714750
nsv997445 CNV gain 25217958

Variation tolerance for WDCP Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDCP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDCP Gene

Disorders for WDCP Gene


  • Note=A chromosomal aberration involving WDCP is found in one subject with colorectal cancer. Translocation t(2;2)(p23.3;p23.1). A 5 million base pair tandem duplication generates an in-frame WDCP-ALK gene fusion. {ECO:0000269 PubMed:22327622}.

Relevant External Links for WDCP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WDCP Gene.

No data available for MalaCards and Genatlas for WDCP Gene

Publications for WDCP Gene

  1. Molecular characterization of WDCP, a novel fusion partner for the anaplastic lymphoma tyrosine kinase ALK. (PMID: 25469238) Yokoyama N. … Miller W.T. (Biomed. Rep. 2015) 2 3 4 65
  2. Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. (PMID: 22327622) Lipson D. … Stephens P.J. (Nat. Med. 2012) 2 3 4 65
  3. Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1. (PMID: 12029088) Scott M.P. … Miller W.T. (J. Biol. Chem. 2002) 3 4 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65

Products for WDCP Gene

Sources for WDCP Gene

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