WBP5 Gene
protein-coding GIFtS: 44
GCID: GC0XP102611
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WW domain binding protein 5
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Aliases
for WBP5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WW Domain Binding Protein 51 2 | | WW Domain Binding Protein 12 | | TCEAL91 2 | | WW Domain-Binding Protein 52 | | WBP-52 3 | | N45 | | DKFZp313K19401 | | NDFIP15 | | Pp21 Homolog2 | | |
Export aliases for WBP5 gene to outside databasesPrevious GC identifers: GC0XP101384 GC0XP102417 GC0XP092274 |
Summaries
for WBP5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WBP5:
The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functionsincluding structural, regulatory, and signaling proteins. The domain is involved in mediating protein-proteininteractions through the binding of polyproline ligands. This gene encodes a WW domain binding protein. This gene alsoencodes a domain with similarity to the transcription elongation factor A, SII-related family. Alternative splicingresults in multiple transcript variants encoding a single isoform. (provided by RefSeq, Jul 2008)
|
Genomic Views
for WBP5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WBP5 gene promoter:
LHX3b/Lhx3b Lmo2 IRF-1 E47 RORalpha2 MZF-1 FOXO4 c-Myb LHX3a/Lhx3a Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for WBP5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WBP5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.2 Ensembl cytogenetic band: Xq22.2 HGNC cytogenetic band: Xq22.2WBP5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP102611: view genomic region
(about GC identifiers)
Start:
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102,611,373 bp from pter |
End:
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102,613,397 bp from pter |
Size:
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2,025 bases |
Orientation:
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plus strand |
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Proteins
for WBP5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WBP5_HUMAN, Q9UHQ7 (See
protein sequence)Recommended Name: WW domain-binding protein 5 Size: 104 amino acids; 12749 Da
Secondary accessions: B2R5H6Explore the universe of human proteins at neXtProt for WBP5: NX_Q9UHQ7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UHQ7
WBP5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001006613.1 NP_001006614.1 NP_001006615.1 NP_057387.1
ENSEMBL proteins: ENSP00000361745 ENSP00000361740
Human Recombinant Protein Products for WBP5:
WBP5 Antibody Products:
Assay Products for WBP5: |
Protein
Domains /
Families
for WBP5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WBP5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UHQ7ProtoNet protein and cluster: Q9UHQ7 UniProtKB/Swiss-Prot: WBP5_HUMAN, Q9UHQ7Similarity: Belongs to the TFS-II family. TFA subfamily |
Function
for WBP5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0050699 | WW domain binding |
IEA | -- |
WBP5 for ontologies About GeneDecksing
Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Wbp5):
WBP5 for phenotypes About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WBP5 (see all 4)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP5 |
|
Pathways & Interactions
for WBP5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WBP5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/11 Interacting proteins for WBP5 (Q9UHQ73 ENSP000003617404) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
|
Drugs & Compounds
for WBP5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WBP5
Search CenterWatch for drugs/clinical trials and news about WBP5
|
Transcripts
for WBP5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WBP5 gene (4 alternative transcripts): NM_001006612.1 NM_001006613.1 NM_001006614.1 NM_016303.2 Unigene Cluster for WBP5: WW domain binding protein 5 Hs.533287 [show with all ESTs]Unigene Representative Sequence: BF2132342 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372661(uc004eke.3 uc004ekd.3 uc004ekf.3 uc004ekg.3)
ENST00000372656
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WBP5 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WBP5 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Synthesis Service for WBP5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WBP5 |
Additional cDNA sequence: AF125535.1 AK312190.1 BC023544.2 15 DOTS entries: DT.87016950 DT.100820196 DT.121301196 DT.92452356 DT.100820191 DT.92452362 DT.100806190 DT.92452352 DT.100649732 DT.100820193 DT.121301182 DT.92452346 DT.92452347 DT.95186081 DT.95186085 24/373 AceView cDNA sequences (see all 373): H98539 CB143782 AA843597 BQ286526 CA414038 AA506182 AW237303 BE569135 AW519189 BX404769 AI031911 AI085974 BG403661 BG252053 CD676798 BF968855 AA876079 CB068017 AW295915 AI014661 AA337106 BX502145 AA044355 R68830
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for WBP5 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d |
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| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for WBP5
|
Expression
for WBP5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WBP5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGAAGAGCC
About this image
See WBP5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WBP5
SOURCE GeneReport for Unigene cluster: Hs.533287
SABiosciences Custom PCR Arrays for WBP5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WBP5
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP5 |
Orthologs
for WBP5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for WBP5 (if available)
TreeFam Gene Tree for WBP5 (if available) |
Paralogs
for WBP5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WBP5 gene
- TCEAL12 TCEAL82 TCEAL72
7 SIMAP similar genes for WBP5 using alignment to 1 protein entry: WBP5_HUMAN:TCEAL1 TCEAL7 TCEAL4 TCEAL3 TCEAL5 TCEAL6
TCEAL8
WBP5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for WBP5
PGOHUM00000247428
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Genomic Variants
for WBP5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WBP5 (102611373 - 102613397 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for WBP5
1 CNV: 96862 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WBP5 |
|
Disorders
/ Diseases
for WBP5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 WBP5 for disorders About MalaCards
WBP5 for disorders About GeneDecksing
OMIM gene information: 612050
OMIM disorders: --
Export disorders for WBP5 gene to outside databases
|
Publications
for WBP5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WBP5 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with WBP5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for WBP5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WBP5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WBP5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WBP5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WBP5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WBP5 gene:
Search GeneIP for patents involving WBP5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WBP5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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 | | | WBP5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP5 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WBP5 |
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