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WBP5 Gene

protein-coding GIFtS: 43

GC0XP102417

WW domain binding protein 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp313K1940 ^¹, ²
OTTHUMP00000023739 ^²
OTTHUMP00000023740 ^²
TCEAL9 ^¹, ²
WBP-5 ^³

Descriptions
WW domain binding protein 1 ^²
WW domain binding protein 5 ^²
pp21 homolog ^²

External Ids
HGNC: 30084¹
Entrez Gene: 51186²
UniProtKB: Q9UHQ7³
Ensembl: ENSG00000185222⁷

Search outside databases for aliases for WBP5 gene

Previous GC identifer: GC0XP101384

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for WBP5:

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of

diverse functions including structural, regulatory, and signaling proteins. The domain is involved

in mediating protein-protein interactions through the binding of polyproline ligands. This gene

encodes a WW domain binding protein. This gene also encodes a domain with similarity to the

transcription elongation factor A, SII-related family. Alternative splicing results in multiple

transcript variants encoding a single isoform. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the WBP5 gene

Entrez Gene cytogenetic band: Xq22.1-q22.2 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq22.2

WBP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP102417: (about GC identifiers)

Start:	102,498,036 bp from pter
End:	102,500,053 bp from pter
Size:	2,018 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011651.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WPB5_HUMAN, Q9UHQ7 (See protein sequence)

Recommended Name: WW domain-binding protein 5

Size: 104 amino acids; 12749 Da

REFSEQ proteins (4 alternative transcripts):

NP_001006613.1 NP_001006614.1 NP_001006615.1 NP_057387.1

ENSEMBL proteins:

ENSP00000361745 ENSP00000361740

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: WBP5

Antibodies for WBP5:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for WBP5
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for WBP5

Assays for WBP5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UHQ7

ProtoNet protein and cluster: Q9UHQ7

UniProtKB/Swiss-Prot: WPB5_HUMAN, Q9UHQ7

Similarity: Belongs to the TFS-II family. TFA subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WBP5)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001006612

Applied Biosystems Silencer® siRNAs for WBP5

Sigma-Aldrich siRNA for WBP5

Sigma-Aldrich shRNA for WBP5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for WBP5
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001006612
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001006612
untagged cDNA clones in CMV expression vector (see all 4): NM_001006612

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001006612

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17353931
GO:0050699	WW domain binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Interacting proteins for WBP5 (Q9UHQ7¹) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
KDELR1 P24390¹ EBI-1051372, EBI-1043076
PIP P12273¹ EBI-1051372, EBI-1049746
RPL31 P62899¹ EBI-1051372, EBI-1053664
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WBP5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WBP5)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001006612

Sigma-Aldrich siRNA for WBP5

Sigma-Aldrich shRNA for WBP5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001006612 NM_001006613 NM_001006614 NM_016303

REFSEQ mRNAs for WBP5 gene (4 alternative transcripts):

NM_001006612.1 NM_001006613.1 NM_001006614.1 NM_016303.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001006612 NM_001006613 NM_001006614 NM_016303

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001006612
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001006612
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001006612

Additional cDNA sequence:

AF125535.1 AK312190.1 BC023544.2 CR613173.1

15 DOTS entries:

DT.87016950 DT.100820196 DT.121301196 DT.92452356 DT.100820191 DT.100806190 DT.92452352 DT.100649732

DT.100820193 DT.92452346 DT.92452347 DT.92452362 DT.95186081 DT.121301182 DT.95186085

24/373 AceView cDNA sequences (see all 373 ):

BX404769 AA843597 AI085974 AA876079 BI325041 H88612 BX095420 BM767051

AA506194 BU155160 BM468347 AA582219 AI692995 AA506298 AI129845 BU752324

BQ286526 CN480683 AI014661 AA446165 BG034522 AA382269 BI090481 AW295915

highest scoring ESTs for WBP5:

AA018277 AA018530 AA031368 AA031369 AA055964 AA102449 AA296636 AA302828 AA322178 AA370945

Unigene Cluster for WBP5:

WW domain binding protein 5

Hs.533287 [show with all ESTs]

Unigene Representative Sequence: BF213234

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for WBP5

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	·	3d
SP1:
SP2:
SP3:									-
SP4:									-

About this scheme

ECgene alternative splicing isoforms for WBP5

2 Ensembl transcripts including schematic representations:

ENST00000372661 ENST00000372656

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WBP5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for WBP5

¹ / ² / ³

4 probe-sets matching WBP5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
57057_r_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.06	AI934584	0.80	1.00	0.91	1
57055_i_at²^{, 3}	U95-B	1	1.00	1.00	1.00	0.94	AI934584	0.80	1.00	0.91	1
217975_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_016303	0.60	1.00	0.82	1
217975_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks WBP5 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGGAAGAGCC

SOURCE GeneReport for Unigene cluster: Hs.533287

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WBP5 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	WBP5¹	--	WW domain binding protein 5	100(n) 100(a)	465779 XM_001136668.1 XP_001136668.1
cow (Bos taurus)	WBP5¹	--	WW domain binding protein 5	90.04(n) 87.36(a)	787302 XM_001254742.1 XP_001254743.1
rat (Rattus norvegicus)	Wbp5¹	--	WW domain binding protein 5	87.07(n) 80.61(a)	680354 XM_001056814.1 XP_001056814.1
mouse (Mus musculus)	Wbp5^{1, 5}	X⁵	WW domain binding protein 5^{1, 5}	83.33(n)¹ 74.04(a)¹	22381¹ NM_011712.2¹ NP_035842.1¹ AK002214⁵ AK017717⁵ (see all 15)

About this table Species with no ortholog for WBP5

ENSEMBL Gene Tree for WBP5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for WBP5 gene

TCEAL1² TCEAL8² TCEAL7²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/28 NCBI SNPs in WBP5 are shown (see all 28 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 20)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7057844^1,2	C,F,H	102498124(+)	`AGCTTC/TCTTCA`	4	--	ut5¹		7		EU EA WA NA	535
	rs2071833^1,2	C,F,H	102497959(-)	`CCCCCC/GACTTA`	4	--	ng5¹		4		EU EA WA	418
	rs17003874^1,2	F,H	102496144(+)	`AACAAC/ATTGAG`	4	--	ng5¹		7		NA EU EA WA	562
--	rs72375119^1,2	--	102496494(+)	`CTTTT-/TTTG TTTAA`	4	--	ng5¹		0	--	--	--	--
--	rs66808820^1,2	--	102497574(+)	`GAGAG-/AGAGAGA`	4	--	ng5¹		0	--	--	--	--
	rs1801005^1,2	--	102499830(-)	`TAGCCA/TTTTTC`	4	--	ut3¹		0	--	--	--	--
--	rs35495761^1,2	--	102498149(+)	`GTCCC-/CTGAGG`	4	--	ut5¹		0	--	--	--	--
--	rs12353561^1,2	--	102500369(+)	`GGGCGC/TGGTGG`	4	--	ng3¹		0	--	--	--	--
--	rs57230597^1,2	--	102496497(+)	`TTTTT-/GTTT AACAA`	4	--	ng5¹		0	--	--	--	--
--	rs3216839^1,2	--	102497662(-)	`AAGAG-/TGAGAT`	4	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for WBP5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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6 PubMed articles for WBP5 gene:

The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)^{3, 4} Hu R.-M.... Chen J.-L. (2000)
Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)³ Ewing R.M....Figeys D. (2007)
FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. (PubMed id 9171351)³ Bedford M.T....Leder P. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 51186	HGNC: 30084	AceView: WBP5	Ensembl:ENSG00000185222	euGenes: HUgn51186
ECgene: WBP5	H-InvDB: WBP5

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for WBP5
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for WBP5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for WBP5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for WBP5		Antibodies for WBP5
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
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WBP5 Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for WBP5

Summaries
for WBP5

Genomic Location
for WBP5

Proteins
for WBP5

Protein Domains/
Families
for WBP5

Gene Function
for WBP5

Pathways & Interactions
for WBP5

Drugs & Compounds
for WBP5

Transcripts
for WBP5

Expression
for WBP5

Orthologs
for WBP5

Paralogs
for WBP5

SNPs/Variants
for WBP5

Disorders & Mutations
for WBP5

Medical News
for WBP5

Publications
for WBP5

Search for WBP5

Genome Databases showing WBP5

Other Databases showing WBP5

Specialized Databases showing WBP5

Licensable Technologies
for WBP5

Services
for WBP5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WBP5 Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor WBP5

Summariesfor WBP5

Genomic Locationfor WBP5

Proteinsfor WBP5

Protein Domains/Familiesfor WBP5

Gene Functionfor WBP5

Pathways & Interactionsfor WBP5

Drugs & Compoundsfor WBP5

Transcriptsfor WBP5

Expression for WBP5

Orthologsfor WBP5

Paralogsfor WBP5

SNPs/Variantsfor WBP5

Disorders & Mutationsfor WBP5

Medical Newsfor WBP5

Publicationsfor WBP5

Search for WBP5

Genome Databases showing WBP5

Other Databases showing WBP5

Specialized Databases showing WBP5

Licensable Technologiesfor WBP5

Servicesfor WBP5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for WBP5

Summaries
for WBP5

Genomic Location
for WBP5

Proteins
for WBP5

Protein Domains/
Families
for WBP5

Gene Function
for WBP5

Pathways & Interactions
for WBP5

Drugs & Compounds
for WBP5

Transcripts
for WBP5

Expression
for WBP5

Orthologs
for WBP5

Paralogs
for WBP5

SNPs/Variants
for WBP5

Disorders & Mutations
for WBP5

Medical News
for WBP5

Publications
for WBP5

Licensable Technologies
for WBP5

Services
for WBP5