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Aliases for WBP5 Gene

Aliases for WBP5 Gene

  • WW Domain Binding Protein 5 2 3
  • Pp21 Homolog 2 3
  • WBP-5 3 4
  • WW Domain Binding Protein 1 3
  • TCEAL9 3
  • WEX6 3

External Ids for WBP5 Gene

Previous GeneCards Identifiers for WBP5 Gene

  • GC0XP101384
  • GC0XP102417
  • GC0XP102611
  • GC0XP092274

Summaries for WBP5 Gene

Entrez Gene Summary for WBP5 Gene

  • The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein. This gene also encodes a domain with similarity to the transcription elongation factor A, SII-related family. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]

GeneCards Summary for WBP5 Gene

WBP5 (WW Domain Binding Protein 5) is a Protein Coding gene. GO annotations related to this gene include WW domain binding. An important paralog of this gene is TCEAL1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WBP5 Gene

Genomics for WBP5 Gene

Regulatory Elements for WBP5 Gene

Genomic Location for WBP5 Gene

Chromosome:
X
Start:
103,356,445 bp from pter
End:
103,358,469 bp from pter
Size:
2,025 bases
Orientation:
Plus strand

Genomic View for WBP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WBP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WBP5 Gene

Proteins for WBP5 Gene

  • Protein details for WBP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHQ7-WBP5_HUMAN
    Recommended name:
    WW domain-binding protein 5
    Protein Accession:
    Q9UHQ7
    Secondary Accessions:
    • B2R5H6

    Protein attributes for WBP5 Gene

    Size:
    104 amino acids
    Molecular mass:
    12749 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WBP5 Gene

Proteomics data for WBP5 Gene at MOPED

Post-translational modifications for WBP5 Gene

  • Ubiquitination at Lys 57 and Lys 86
  • Modification sites at PhosphoSitePlus

Other Protein References for WBP5 Gene

No data available for DME Specific Peptides for WBP5 Gene

Domains & Families for WBP5 Gene

Protein Domains for WBP5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WBP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHQ7

UniProtKB/Swiss-Prot:

WBP5_HUMAN :
  • Belongs to the TFS-II family. TFA subfamily.
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with WBP5: view

No data available for Gene Families for WBP5 Gene

Function for WBP5 Gene

Gene Ontology (GO) - Molecular Function for WBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050699 WW domain binding IBA --
genes like me logo Genes that share ontologies with WBP5: view

Phenotypes for WBP5 Gene

genes like me logo Genes that share phenotypes with WBP5: view

Animal Model Products

miRNA for WBP5 Gene

miRTarBase miRNAs that target WBP5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WBP5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for WBP5 Gene

Localization for WBP5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WBP5 Gene COMPARTMENTS Subcellular localization image for WBP5 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for WBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with WBP5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WBP5 Gene

Pathways & Interactions for WBP5 Gene

SuperPathways for WBP5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with WBP5: view

No data available for Pathways by source and SIGNOR curated interactions for WBP5 Gene

Drugs & Compounds for WBP5 Gene

No Compound Related Data Available

Transcripts for WBP5 Gene

Unigene Clusters for WBP5 Gene

WW domain binding protein 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WBP5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WBP5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d
SP1:
SP2:
SP3: -
SP4: -

Relevant External Links for WBP5 Gene

GeneLoc Exon Structure for
WBP5
ECgene alternative splicing isoforms for
WBP5

Expression for WBP5 Gene

mRNA expression in normal human tissues for WBP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WBP5 Gene

This gene is overexpressed in Tlymphocyte (51.0), Cervix (9.2), and Platelet (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WBP5 Gene



SOURCE GeneReport for Unigene cluster for WBP5 Gene Hs.533287

genes like me logo Genes that share expression patterns with WBP5: view

Protein tissue co-expression partners for WBP5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WBP5 Gene

Orthologs for WBP5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for WBP5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WBP5 35
  • 89.87 (n)
  • 86.08 (a)
WBP5 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WBP5 35
  • 89.74 (n)
  • 79.61 (a)
WBP5 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wbp5 35
  • 83.33 (n)
  • 74.04 (a)
Wbp5 16
Wbp5 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WBP5 35
  • 100 (n)
  • 100 (a)
WBP5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wbp5 35
  • 87.18 (n)
  • 80.77 (a)
Species with no ortholog for WBP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WBP5 Gene

ENSEMBL:
Gene Tree for WBP5 (if available)
TreeFam:
Gene Tree for WBP5 (if available)

Paralogs for WBP5 Gene

Paralogs for WBP5 Gene

(6) SIMAP similar genes for WBP5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for WBP5 Gene

genes like me logo Genes that share paralogs with WBP5: view

Variants for WBP5 Gene

Sequence variations from dbSNP and Humsavar for WBP5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1045049 -- 103,357,901(+) TTAGA(C/G)AAGTG missense, reference
rs1801005 -- 103,358,246(-) TAGCC(A/T)TTTTC utr-variant-3-prime
rs1801006 -- 103,358,261(-) TATTC(A/C)CATAT utr-variant-3-prime
rs1801007 -- 103,358,372(-) GAAAA(A/C)TCATT utr-variant-3-prime
rs1801009 -- 103,358,419(-) ATGTG(G/T)GTTAA utr-variant-3-prime

Variation tolerance for WBP5 Gene

Residual Variation Intolerance Score: 42.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WBP5 Gene

HapMap Linkage Disequilibrium report
WBP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for WBP5 Gene

Disorders for WBP5 Gene

Relevant External Links for WBP5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WBP5
genes like me logo Genes that share disorders with WBP5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WBP5 Gene

Publications for WBP5 Gene

  1. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 67
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for WBP5 Gene

Sources for WBP5 Gene

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