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Aliases for WBP4 Gene

Aliases for WBP4 Gene

  • WW Domain Binding Protein 4 2 3 5
  • Formin Binding Protein 21 2 3
  • FBP21 3 4
  • WBP-4 3 4
  • WW Domain-Containing Binding Protein 4 3
  • WW Domain-Containing-Binding Protein 4 4
  • Domain-Containing Binding Protein 4 3
  • WW Domain-Binding Protein 4 3
  • Formin-Binding Protein 21 4
  • FNBP21 4

External Ids for WBP4 Gene

Previous GeneCards Identifiers for WBP4 Gene

  • GC13P039621
  • GC13P035622
  • GC13P040572
  • GC13P039433
  • GC13P040533
  • GC13P041635
  • GC13P022436

Summaries for WBP4 Gene

Entrez Gene Summary for WBP4 Gene

  • This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. [provided by RefSeq, Jul 2008]

GeneCards Summary for WBP4 Gene

WBP4 (WW Domain Binding Protein 4) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and proline-rich region binding.

UniProtKB/Swiss-Prot for WBP4 Gene

  • Promotes pre-mRNA splicing. A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex.

Gene Wiki entry for WBP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WBP4 Gene

Genomics for WBP4 Gene

Regulatory Elements for WBP4 Gene

Enhancers for WBP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F041014 1.4 FANTOM5 ENCODE 25.3 -43.1 -43144 8.2 ATF1 PKNOX1 WRNIP1 SIN3A ZNF2 YY1 CBX5 FOS JUNB TBX21 WBP4 ELF1 SLC25A15 RGCC NAA16 GC13M041023 RGS17P1
GH13F041056 1.4 Ensembl ENCODE 22.8 +0.0 19 9.7 CREB3L1 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 LINC00548 WBP4 TPTE2P5 MTRF1 NAA16 RNU6-57P CYCSP34 ELF1
GH13F041001 1.3 Ensembl ENCODE 22.7 -55.3 -55274 10.0 PKNOX1 ATF1 MLX ARID4B DMAP1 YY1 SLC30A9 CBX5 FOS JUNB WBP4 ELF1 CYCSP34 SLC25A15 SUGT1P3 RGS17P1 GC13M041023
GH13F041048 1.2 FANTOM5 Ensembl ENCODE 15.4 -11.2 -11174 2.6 CTCF PKNOX1 JUN MNT PRDM1 WBP4 ELF1 CYCSP34 RGCC NAA16 TRE-TTC1-2 GC13M041020 GC13M041024
GH13F041034 0.8 Ensembl ENCODE 21.3 -26.2 -26174 1.0 JUN BHLHE40 ZNF600 ATF2 SPI1 WBP4 GC13M041024 GC13M041020 TRE-TTC1-2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WBP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for WBP4 Gene

Chromosome:
13
Start:
41,061,274 bp from pter
End:
41,084,006 bp from pter
Size:
22,733 bases
Orientation:
Plus strand

Genomic View for WBP4 Gene

Genes around WBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WBP4 Gene

Proteins for WBP4 Gene

  • Protein details for WBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75554-WBP4_HUMAN
    Recommended name:
    WW domain-binding protein 4
    Protein Accession:
    O75554
    Secondary Accessions:
    • B7Z4M2
    • Q32P29

    Protein attributes for WBP4 Gene

    Size:
    376 amino acids
    Molecular mass:
    42507 Da
    Quaternary structure:
    • Associated with U2 snRNPs. Binds splicing factors SNRPB, SNRPC and SF1. Interacts via the WW domains with the Pro-rich domains of KHDRBS1/SAM68 (By similarity). Interacts via the WW domains with the Pro-rich domains of WBP11.

    Three dimensional structures from OCA and Proteopedia for WBP4 Gene

    Alternative splice isoforms for WBP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WBP4 Gene

Post-translational modifications for WBP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WBP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WBP4 Gene

Domains & Families for WBP4 Gene

Protein Domains for WBP4 Gene

Suggested Antigen Peptide Sequences for WBP4 Gene

Graphical View of Domain Structure for InterPro Entry

O75554

UniProtKB/Swiss-Prot:

WBP4_HUMAN :
  • The WW domain recognizes the proline, glycine and methionine-rich (PGM) motif present in the splicing factors, as well as the Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins.
  • Contains 1 matrin-type zinc finger.
Domain:
  • The WW domain recognizes the proline, glycine and methionine-rich (PGM) motif present in the splicing factors, as well as the Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins.
  • Contains 2 WW domains.
Similarity:
  • Contains 1 matrin-type zinc finger.
genes like me logo Genes that share domains with WBP4: view

No data available for Gene Families for WBP4 Gene

Function for WBP4 Gene

Molecular function for WBP4 Gene

GENATLAS Biochemistry:
WW domain binding protein 4, formin binding 21,general spliceosomal protein binding a third class of proline-glycine methionine (PGM) rich motif
UniProtKB/Swiss-Prot Function:
Promotes pre-mRNA splicing. A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex.

Gene Ontology (GO) - Molecular Function for WBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 17500595
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0070064 proline-rich region binding IPI 19592703
genes like me logo Genes that share ontologies with WBP4: view
genes like me logo Genes that share phenotypes with WBP4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WBP4

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WBP4 Gene

Localization for WBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WBP4 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WBP4 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2

Gene Ontology (GO) - Cellular Components for WBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex IEA --
GO:0005886 plasma membrane IDA --
GO:0016607 nuclear speck IEA,IDA 19592703
genes like me logo Genes that share ontologies with WBP4: view

Pathways & Interactions for WBP4 Gene

genes like me logo Genes that share pathways with WBP4: view

Pathways by source for WBP4 Gene

Gene Ontology (GO) - Biological Process for WBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0045292 mRNA cis splicing, via spliceosome IDA 19592703
genes like me logo Genes that share ontologies with WBP4: view

No data available for SIGNOR curated interactions for WBP4 Gene

Transcripts for WBP4 Gene

mRNA/cDNA for WBP4 Gene

Unigene Clusters for WBP4 Gene

WW domain binding protein 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WBP4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WBP4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b
SP1: -
SP2:
SP3:
SP4:
SP5:

Relevant External Links for WBP4 Gene

GeneLoc Exon Structure for
WBP4
ECgene alternative splicing isoforms for
WBP4

Expression for WBP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WBP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WBP4 Gene

This gene is overexpressed in Bone (26.0), Blymphocyte (10.1), Peripheral blood mononuclear cells (9.9), and CD8 Tcells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WBP4 Gene



Protein tissue co-expression partners for WBP4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WBP4 Gene:

WBP4

SOURCE GeneReport for Unigene cluster for WBP4 Gene:

Hs.411300
genes like me logo Genes that share expression patterns with WBP4: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WBP4 Gene

Orthologs for WBP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for WBP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WBP4 34 35
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia WBP4 34 35
  • 90.84 (n)
cow
(Bos Taurus)
Mammalia WBP4 34 35
  • 89.81 (n)
rat
(Rattus norvegicus)
Mammalia Wbp4 34
  • 85.52 (n)
mouse
(Mus musculus)
Mammalia Wbp4 34 16 35
  • 84 (n)
oppossum
(Monodelphis domestica)
Mammalia WBP4 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WBP4 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves WBP4 34 35
  • 65.55 (n)
lizard
(Anolis carolinensis)
Reptilia WBP4 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wbp4 34
  • 59.71 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1414 34
zebrafish
(Danio rerio)
Actinopterygii wbp4 34 35
  • 53.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4291 34 35
  • 45.8 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010339 34
  • 42.9 (n)
Species where no ortholog for WBP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WBP4 Gene

ENSEMBL:
Gene Tree for WBP4 (if available)
TreeFam:
Gene Tree for WBP4 (if available)

Paralogs for WBP4 Gene

No data available for Paralogs for WBP4 Gene

Variants for WBP4 Gene

Sequence variations from dbSNP and Humsavar for WBP4 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_036352 A breast cancer sample
rs10507490 -- 41,064,711(+) TGAGT(C/T)CTCAT intron-variant
rs111232890 -- 41,083,782(+) TGTTT(A/G)CTTAA utr-variant-3-prime
rs111538493 -- 41,077,022(+) AACAA(A/C/G)AAAAT intron-variant
rs111665018 -- 41,062,809(+) TTTTA(C/T)GTACA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WBP4 Gene

Variant ID Type Subtype PubMed ID
nsv832587 CNV gain 17160897
nsv561538 CNV loss 21841781
esv3631865 CNV loss 21293372
esv3580615 CNV loss 25503493

Variation tolerance for WBP4 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WBP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WBP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WBP4 Gene

Disorders for WBP4 Gene

Relevant External Links for WBP4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WBP4

No disorders were found for WBP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WBP4 Gene

Publications for WBP4 Gene

  1. Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21). (PMID: 19592703) Huang X. … Shi Y. (J. Biol. Chem. 2009) 3 4 22 64
  2. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. (PMID: 9724750) Bedford M.T. … Leder P. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for WBP4 Gene

Sources for WBP4 Gene

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