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Aliases for WBP4 Gene

Aliases for WBP4 Gene

  • WW Domain Binding Protein 4 2 3
  • WW Domain-Containing-Binding Protein 4 3 4
  • Formin Binding Protein 21 2 3
  • Formin-Binding Protein 21 3 4
  • FBP21 3 4
  • WBP-4 3 4
  • WW Domain-Containing Binding Protein 4 3
  • Domain-Containing Binding Protein 4 3
  • WW Domain-Binding Protein 4 3
  • FNBP21 4

External Ids for WBP4 Gene

Previous GeneCards Identifiers for WBP4 Gene

  • GC13P039621
  • GC13P035622
  • GC13P040572
  • GC13P039433
  • GC13P040533
  • GC13P041635
  • GC13P022436

Summaries for WBP4 Gene

Entrez Gene Summary for WBP4 Gene

  • This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. [provided by RefSeq, Jul 2008]

GeneCards Summary for WBP4 Gene

WBP4 (WW Domain Binding Protein 4) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and proline-rich region binding.

UniProtKB/Swiss-Prot for WBP4 Gene

  • Promotes pre-mRNA splicing. A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex.

Gene Wiki entry for WBP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WBP4 Gene

Genomics for WBP4 Gene

Regulatory Elements for WBP4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WBP4 Gene

41,061,274 bp from pter
41,084,006 bp from pter
22,733 bases
Plus strand

Genomic View for WBP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WBP4 Gene

Proteins for WBP4 Gene

  • Protein details for WBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WW domain-binding protein 4
    Protein Accession:
    Secondary Accessions:
    • B7Z4M2
    • Q32P29

    Protein attributes for WBP4 Gene

    376 amino acids
    Molecular mass:
    42507 Da
    Quaternary structure:
    • Associated with U2 snRNPs. Binds splicing factors SNRPB, SNRPC and SF1. Interacts via the WW domains with the Pro-rich domains of KHDRBS1/SAM68 (By similarity). Interacts via the WW domains with the Pro-rich domains of WBP11.

    Three dimensional structures from OCA and Proteopedia for WBP4 Gene

    Alternative splice isoforms for WBP4 Gene


neXtProt entry for WBP4 Gene

Proteomics data for WBP4 Gene at MOPED

Post-translational modifications for WBP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WBP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WBP4 Gene

Domains for WBP4 Gene

Protein Domains for WBP4 Gene

Suggested Antigen Peptide Sequences for WBP4 Gene

Graphical View of Domain Structure for InterPro Entry



  • O75554
  • The WW domain recognizes the proline, glycine and methionine-rich (PGM) motif present in the splicing factors, as well as the Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins.
  • Contains 2 WW domains.
  • Contains 1 matrin-type zinc finger.
genes like me logo Genes that share domains with WBP4: view

No data available for Gene Families for WBP4 Gene

Function for WBP4 Gene

Molecular function for WBP4 Gene

GENATLAS Biochemistry: WW domain binding protein 4, formin binding 21,general spliceosomal protein binding a third class of proline-glycine methionine (PGM) rich motif
UniProtKB/Swiss-Prot Function: Promotes pre-mRNA splicing. A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex.

Gene Ontology (GO) - Molecular Function for WBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 17500595
GO:0008270 zinc ion binding IEA --
GO:0070064 proline-rich region binding IPI 19592703
genes like me logo Genes that share ontologies with WBP4: view

Animal Model Products

CRISPR Products

miRNA for WBP4 Gene

miRTarBase miRNAs that target WBP4

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for WBP4 Gene

Localization for WBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WBP4 Gene

Nucleus speckle.

Subcellular locations from

Jensen Localization Image for WBP4 Gene COMPARTMENTS Subcellular localization image for WBP4 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for WBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex IEA --
GO:0005886 plasma membrane IDA --
GO:0016607 nuclear speck IDA 19592703
genes like me logo Genes that share ontologies with WBP4: view

Pathways for WBP4 Gene

SuperPathways for WBP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045292 mRNA cis splicing, via spliceosome IDA 19592703
genes like me logo Genes that share ontologies with WBP4: view

No data available for Pathways by source for WBP4 Gene

Transcripts for WBP4 Gene

mRNA/cDNA for WBP4 Gene

Unigene Clusters for WBP4 Gene

WW domain binding protein 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WBP4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WBP4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b
SP1: -

Relevant External Links for WBP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WBP4 Gene

mRNA expression in normal human tissues for WBP4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WBP4 Gene

SOURCE GeneReport for Unigene cluster for WBP4 Gene Hs.411300

genes like me logo Genes that share expressions with WBP4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WBP4 Gene

Orthologs for WBP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for WBP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WBP4 35
  • 99.65 (n)
  • 98.94 (a)
WBP4 36
  • 99 (a)
(Bos Taurus)
Mammalia WBP4 35
  • 89.81 (n)
  • 85.79 (a)
WBP4 36
  • 81 (a)
(Canis familiaris)
Mammalia WBP4 35
  • 90.84 (n)
  • 88.95 (a)
WBP4 36
  • 89 (a)
(Mus musculus)
Mammalia Wbp4 35
  • 84 (n)
  • 79.36 (a)
Wbp4 16
Wbp4 36
  • 78 (a)
(Monodelphis domestica)
Mammalia WBP4 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia WBP4 36
  • 56 (a)
(Rattus norvegicus)
Mammalia Wbp4 35
  • 85.52 (n)
  • 78.02 (a)
(Gallus gallus)
Aves WBP4 35
  • 65.55 (n)
  • 58.82 (a)
WBP4 36
  • 50 (a)
(Anolis carolinensis)
Reptilia WBP4 36
  • 53 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1414 35
tropical clawed frog
(Silurana tropicalis)
Amphibia wbp4 35
  • 59.71 (n)
  • 51.37 (a)
(Danio rerio)
Actinopterygii wbp4 35
  • 53.78 (n)
  • 48.62 (a)
wbp4 36
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010339 35
  • 42.9 (n)
  • 33.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4291 35
  • 45.8 (n)
  • 35.26 (a)
CG4291 36
  • 30 (a)
Species with no ortholog for WBP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WBP4 Gene

Gene Tree for WBP4 (if available)
Gene Tree for WBP4 (if available)

Paralogs for WBP4 Gene

No data available for Paralogs for WBP4 Gene

Variants for WBP4 Gene

Sequence variations from dbSNP and Humsavar for WBP4 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1329520 -- 41,064,475(+) CCTCC(A/G)TAGAA intron-variant
rs2766726 -- 41,065,672(+) ATGGT(C/G)AAAAT intron-variant
rs2772183 -- 41,081,931(+) CTTTC(C/T)GGTCC intron-variant
rs3072012 -- 41,066,788(+) TGCAT(-/GTAT)CTTTT intron-variant
rs3794330 -- 41,083,204(+) AGAAA(C/T)AGGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WBP4 Gene

Variant ID Type Subtype PubMed ID
nsv832587 CNV Gain 17160897

Relevant External Links for WBP4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WBP4 Gene

Disorders for WBP4 Gene

No disorders were found for WBP4 Gene.

No data available for UniProtKB/Swiss-Prot for WBP4 Gene

Publications for WBP4 Gene

  1. Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21). (PMID: 19592703) Huang X. … Shi Y. (J. Biol. Chem. 2009) 3 4 23
  2. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. (PMID: 9724750) Bedford M.T. … Leder P. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for WBP4 Gene

Sources for WBP4 Gene

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