WBP4 Gene
protein-coding GIFtS: 49
GCID: GC13P041635
|
|
WW domain binding protein 4
| |
Aliases
for WBP4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WW Domain Binding Protein 41 2 | | Domain-Containing Binding Protein 42 | | FBP211 2 3 | | Formin Binding Protein 212 | | Formin-Binding Protein 212 3 | | WW Domain-Binding Protein 42 | | WBP-42 3 | | WW Domain-Containing Binding Protein 42 | | WW Domain-Containing-Binding Protein 42 3 | | FNBP213 | | MGC1173101 | | |
Export aliases for WBP4 gene to outside databasesPrevious GC identifers: GC13P039621 GC13P035622 GC13P040572 GC13P039433 GC13P040533 GC13P022436 |
Summaries
for WBP4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WBP4:
This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globularstructure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that mayplay a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: WBP4_HUMAN, O75554Function: Promotes pre-mRNA splicing. A spliceosome-associated protein; may play a role in cross-intron bridging of U1and U2 snRNPs in the mammalian A complex
Gene Wiki entry for WBP4
|
Genomic Views
for WBP4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WBP4 gene promoter:
STAT1 STAT1beta Nkx2-5 STAT1alpha MEF-2A STAT2 STAT3 Msx-1 aMEF-2 MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for WBP4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WBP4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14.11 Ensembl cytogenetic band: 13q14.11 HGNC cytogenetic band: 13q13.3WBP4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P041635: view genomic region
(about GC identifiers)
Start:
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41,635,410 bp from pter |
End:
|
41,658,139 bp from pter |
Size:
|
22,730 bases |
Orientation:
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plus strand |
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Proteins
for WBP4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WBP4_HUMAN, O75554 (See
protein sequence)Recommended Name: WW domain-binding protein 4 Size: 376 amino acids; 42507 Da
Subunit: Associated with U2 snRNPs. Binds splicing factors SNRPB, SNRPC and SF1. Interacts via the WW domains with thePro-rich domains of KHDRBS1/SAM68 (By similarity). Interacts via the WW domains with the Pro-rich domains of WBP11
Subcellular location: Nucleus speckle
2 PDB 3D structures from  and Proteopedia  for WBP4:2DK1 (3D)
2JXW (3D)
Secondary accessions: Q32P29Explore the universe of human proteins at neXtProt for WBP4: NX_O75554
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75554
WBP4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009118.1
ENSEMBL proteins: ENSP00000368801 ENSP00000439301
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
WBP4 for ontologies About GeneDecksing
WBP4 Antibody Products:
Assay Products for WBP4: |
Protein
Domains /
Families
for WBP4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WBP4 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75554ProtoNet protein and cluster: O75554 1 Blocks protein family: IPB003604 Zn-finger
UniProtKB/Swiss-Prot: WBP4_HUMAN, O75554Domain: The WW domain recognizes the proline, glycine and methionine-rich (PGM) motif present in the splicing factors,as well as the Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins (By similarity)Similarity: Contains 1 matrin-type zinc fingerSimilarity: Contains 2 WW domains |
Function
for WBP4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: WBP4_HUMAN, O75554Function: Promotes pre-mRNA splicing. A spliceosome-associated protein; may play a role in cross-intron bridging of U1and U2 snRNPs in the mammalian A complex Genatlas biochemistry entry for WBP4:WW domain binding protein 4, formin binding 21,general spliceosomal protein binding a third class of proline-glycinemethionine (PGM) rich motif
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WBP4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP4 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
WBP4 for ontologies About GeneDecksing
|
Pathways & Interactions
for WBP4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WBP4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/72 Interacting proteins for WBP4 (O755542, 3 ENSP000003688014) via UniProtKB, MINT, STRING, and/or I2D (see all 72)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| KHDRBS1 | Q076662, 3, ENSP000003138294 | MINT-73037 MINT-56718 MINT-56719 MINT-56723 MINT-56722 I2D:
score=4 STRING: ENSP00000313829 | | DDX23 | Q9BUQ82, 3, ENSP000003107234 | MINT-73032 I2D:
score=3 STRING: ENSP00000310723 | | HLTF | Q145272, 3, ENSP000003089444 | MINT-73028 I2D:
score=3 STRING: ENSP00000308944 | | PABPC1 | P119402, 3, ENSP000003130074 | MINT-73040 I2D:
score=3 STRING: ENSP00000313007 | | PRPF3 | O433952, 3, ENSP000003153794 | MINT-73041 I2D:
score=3 STRING: ENSP00000315379 |
About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045292 | mRNA cis splicing, via spliceosome |
IDA | 19592703 |
WBP4 for ontologies About GeneDecksing
|
Drugs & Compounds
for WBP4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WBP4
Search CenterWatch for drugs/clinical trials and news about WBP4
|
Transcripts
for WBP4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WBP4 gene: NM_007187.3 Unigene Cluster for WBP4: WW domain binding protein 4 Hs.411300 [show with all ESTs]Unigene Representative Sequence: AF0711852 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000379487(uc001uxt.3 uc010tfd.2) ENST00000542082
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WBP4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WBP4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WBP4 (NM_007187) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WBP4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WBP4 |
Additional cDNA sequence: AF071185.1 AK000979.1 AK001557.1 AK297536.1 AK314525.1 BC104879.1 BC108310.1 12 DOTS entries: DT.92426388 DT.95200477 DT.451927 DT.91637634 DT.75185738 DT.100009360 DT.100729675 DT.120779043 DT.40133310 DT.40219223 DT.40234587 DT.95256657 24/160 AceView cDNA sequences (see all 160): AI734228 AI281652 BQ771684 AA043973 AV685394 AU118067 BU686887 BQ441789 BU623161 CR624814 BU689600 AI076299 BQ027684 CB852317 AA433952 BU781855 AI351269 AA416964 BM462928 AI478200 AA044009 BQ014713 AI627900 AW134743
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for WBP4 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for WBP4
|
Expression
for WBP4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WBP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAGAAAAAA
About this image
See WBP4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WBP4
SOURCE GeneReport for Unigene cluster: Hs.411300
SABiosciences Custom PCR Arrays for WBP4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WBP4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WBP4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WBP4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WBP4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP4 |
Orthologs
for WBP4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WBP4 gene from 9/23 species (see all 23) About this table
ENSEMBL Gene Tree for WBP4 (if available)
TreeFam Gene Tree for WBP4 (if available) |
Paralogs
for WBP4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for WBP4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WBP4 (41635410 - 41658139 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for WBP4
1 CNV: 4799 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WBP4 |
|
Disorders
/ Diseases
for WBP4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 WBP4 for disorders About MalaCards
WBP4 for disorders About GeneDecksing
OMIM gene information: 604981
OMIM disorders: --
Export disorders for WBP4 gene to outside databases
|
Publications
for WBP4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WBP4 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with WBP4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. (PubMed id 9724750)1, 2, 3 Bedford M.T.... Leder P. (1998)
- Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21). (PubMed id 19592703)1, 2, 9 Huang X.... Shi Y. (2009)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Multivalent binding of formin-binding protein 21 (FBP 21)-tandem-WW domains fosters protein recognition in the pre-spliceosome. (PubMed id 21917930)1 Klippel S....Freund C. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site. (PubMed id 15837427)1 Takahara T....Yanagisawa S. (2005)
|
External Searches for WBP4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WBP4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WBP4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WBP4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WBP4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WBP4 gene:
Search GeneIP for patents involving WBP4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WBP4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WBP4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WBP4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WBP4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WBP4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WBP4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WBP4 |
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| |  |  |  |  | | | | |
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 | | | WBP4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP4 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WBP4 |
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