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Aliases & Descriptions for WBP4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FBP21 1, 2, 3 | | FNBP21 3 | | MGC117310 1, 2 | | OTTHUMP00000018311 2 | | WBP-4 3 |
| | | Descriptions |
|---|
| Formin-binding protein 21 3 | | WW domain binding protein 4 (formin binding protein 21) 2 | | WW domain-containing binding protein 4 2 | | WW domain-containing-binding protein 4 3 | | domain-containing binding protein 4 2 | | formin binding protein 21 2 |
|
| | Search outside databases for aliases for WBP4 genePrevious GC identifers: GC13P039621 GC13P035622 GC13P040572 GC13P039433 |
Summaries for WBP4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for WBP4: This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. [provided by RefSeq] UniProtKB/Swiss-Prot: WBP4_HUMAN, O75554Function: A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complexGene Wiki entry for WBP4 |
Genomic Location for WBP4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the WBP4 gene 
Entrez Gene cytogenetic band: 13q14.11 Ensembl cytogenetic band: 13q14.11 HGNC cytogenetic band: 13q13.3WBP4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P040533:
(about GC identifiers)
Start:
|
40,533,662 bp from pter |
End:
|
40,556,139 bp from pter |
Size:
|
22,478 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000013.9 NT_024524.13
| Proteins for WBP4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: WBP4_HUMAN, O75554 (See
protein sequence)Recommended Name: WW domain-binding protein 4 Size: 376 amino acids; 42507 Da
Subunit: Associated with U2 snRNPs. Binds splicing factors SNRPB, SNRPC and SF1. Interacts via the WW domains with the Pro-rich domains of KHDRBS1/SAM68 (By similarity)
Subcellular location: Nucleus speckle
PDB structure from and Proteopedia :2DK1 (3D)
 2JXW (3D)
 
Secondary accessions: Q32P29Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_009118.1
ENSEMBL proteins: ENSP00000368801
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for WBP4: Assays for WBP4: | Protein
Domains/ Families for WBP4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O75554
ProtoNet protein and cluster: O75554 1 Blocks protein family: IPB003604 Zn-finger
UniProtKB/Swiss-Prot: WBP4_HUMAN, O75554Domain: The WW domain recognizes the proline, glycine and methionine-rich (PGM) motif present in the splicing factors, as well as the Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins (By similarity)Similarity: Contains 1 matrin-type zinc fingerSimilarity: Contains 2 WW domains | Gene Function for WBP4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007187
Applied Biosystems Silencer® siRNAs for WBP4
Sigma-Aldrich siRNA for WBP4  Sigma-Aldrich shRNA for WBP4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007187                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007187                                  untagged cDNA clones in CMV expression vector (see all 2): NM_007187 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_007187
UniProtKB/Swiss-Prot: WBP4_HUMAN, O75554Function: A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complexGenatlas biochemistry entry for WBP4:WW domain binding protein 4, formin binding 21,general spliceosomal protein binding a third class of proline-glycine methionine (PGM) rich motif4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for WBP4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/50 Interacting proteins for WBP4 (O755542 ENSP000003688013) via UniProtKB, MINT, and/or STRING (see all 50
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006397 | mRNA processing |
IEA | -- | | GO:0008380 | RNA splicing |
IEA | -- | About this table
|
Drugs & Compounds for WBP4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for WBP4
|
Transcripts for WBP4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007187
Sigma-Aldrich siRNA for WBP4  Sigma-Aldrich shRNA for WBP4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_007187 REFSEQ mRNAs for WBP4 gene: NM_007187.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_007187               OriGene GFP tagged cDNA clone in CMV expression vector: NM_007187                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007187                                  untagged cDNA clones in CMV expression vector (see all 2): NM_007187  Additional cDNA sequence: AF071185.1 AK000979.1 AK001557.1 AK297536.1 AK314525.1 BC104879.1 BC108310.1 CR603878.1 CR624814.1 12 DOTS entries: DT.92426388 DT.95200477 DT.451927 DT.40219223 DT.91637634 DT.75185738 DT.100009360 DT.100729675 DT.120779043 DT.40133310 DT.40234587 DT.95256657 24/160 AceView cDNA sequences (see all 160
):CB852317 AV685394 AW237795 AI281652 CD364365 AI668682 AI351269 AA433952 BQ228821 BQ015589 BQ441789 AW134743 BF513662 BU689600 AI354710 BM456326 AW328358 BP340945 AW328359 AA044009 AI700864 BM462928 BE644677 AL537203
highest scoring ESTs for WBP4:AF071185 AA043973 AA044009 AA207256 AA284444 AA287005 AA393233 AA416964 AA433952 AA702632 Unigene Cluster for WBP4: WW domain binding protein 4 (formin binding protein 21) Hs.411300 [show with all ESTs]Unigene Representative Sequence: AF071185
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for WBP4
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | |
| SP1: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for WBP4
1 Ensembl transcript including schematic representation: ENST00000379487
|
Expression for WBP4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| WBP4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for WBP4
1 / 2 / 3 7 probe-sets matching WBP4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TAAGAAAAAA
SOURCE GeneReport for Unigene cluster: Hs.411300
Expression variation in blood from EXPOLDB for WBP4 |
Orthologs for WBP4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for WBP4 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for WBP4
ENSEMBL Gene Tree for WBP4 | Paralogs for WBP4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for WBP4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for WBP4 (up to first 250kb)
|
Disorders & Mutations for WBP4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604981
|
Medical News for WBP4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for WBP4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for WBP4 gene (see all 12
):- WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. (PubMed id 9724750)2, 3, 4 Bedford M.T.... Leder P. (1998)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)3, 4 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)4 Sjoeblom T.... Velculescu V.E. (2006)
- Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site. (PubMed id 15837427)3 Takahara T....Yanagisawa S. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. (PubMed id 11604498)3 Goldstrohm A.C....Garcia-Blanco M.A. (2001)
- Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains. (PubMed id 10748127)3 Bedford M.T.... Richard S. (2000)
- Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. (PubMed id 8605874)3 Chan D.C....Leder P. (1996)
|
Search for WBP4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing WBP4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing WBP4
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WBP4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for WBP4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for WBP4:

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Incremental update: 13 Oct 2009
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