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WBP2NL Gene

protein-coding   GIFtS: 46

GC22P040724
WBP2 N-terminal like
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for WBP2NL

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
FLJ26145 1, 2
MGC26816 1, 2
OTTHUMP00000028745 2
PAWP 1, 2, 3, 5
Descriptions
WBP2 N-terminal like 2
WW domain-binding protein 2-like 3
postacrosomal sheath WW domain-binding protein 2
External Ids
HGNC: 283891
Entrez Gene: 1646842
UniProtKB: Q6ICG83
Ensembl: ENSG000001830667
Search outside databases for aliases for WBP2NL gene

Summaries
for WBP2NL

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for WBP2NL:
WBP2NL is a sperm-specific WW domain-binding protein that promotes meiotic resumption and
pronuclear development during oocyte fertilization (Wu et al., 2007 [PubMed 17289678]).[supplied
by OMIM]

UniProtKB/Swiss-Prot: WBP2L_HUMAN, Q6ICG8
Function: May play a role in meotic resumption and pronuclear formation, mediated by a WW
domain-signaling pathway during fertilization (By similarity)

Genomic Location
for WBP2NL

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WBP2NL gene  

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

WBP2NL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P040724:     (about GC identifiers)

Start:
 40,724,675 bp from pter
End:
 40,758,879 bp from pter
Size:
 34,205 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000022.9  NT_011520.11  

Proteins
for WBP2NL

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: WBP2L_HUMAN, Q6ICG8 (See protein sequence)
Recommended Name: Postacrosomal sheath WW domain-binding protein  
Size: 309 amino acids; 31909 Da
Sequence caution: Sequence=AAH22549.1; Type=Frameshift; Positions=159;
Secondary accessions: A3KFF7 Q8TBF0 Q8TBF3

REFSEQ proteins: NP_689826.2  

ENSEMBL proteins: 
ENSP00000332983 ENSP00000328800 


Human Recombinant Proteins 
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Browse Purified and Recombinant Proteins at Millipore
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Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (WBP2NL)
Human Recombinant Proteins from Abnova (WBP2NL)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0033011 perinuclear theca ISS17289678
About this table

Antibodies for WBP2NL: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
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Antibodies from Abcam (WBP2NL), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (WBP2NL)
Novus Biologicals Antibodies for WBP2NL

Assays for WBP2NL: 
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Protein Domains/
Families
for WBP2NL

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro domain/family:
 IPR018826 WW-domain-binding


   GeneDecks  WBP2NL for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q6ICG8

ProtoNet protein and cluster: Q6ICG8

UniProtKB/Swiss-Prot: WBP2L_HUMAN, Q6ICG8
Similarity: Contains 1 GRAM domain

Gene Function
for WBP2NL

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (WBP2NL)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152613

              Applied Biosystems Silencer® siRNAs for WBP2NL

              Sigma-Aldrich siRNA for WBP2NL  
                     Sigma-Aldrich shRNA for WBP2NL  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for WBP2NL
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_152613
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_152613
                                 untagged cDNA clone in CMV expression vector: NM_152613 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_152613

UniProtKB/Swiss-Prot: WBP2L_HUMAN, Q6ICG8
Function: May play a role in meotic resumption and pronuclear formation, mediated by a WW
domain-signaling pathway during fertilization (By similarity)

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0050699 WW domain binding ISS17289678
About this table

Pathways & Interactions
for WBP2NL

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007126 meiosis IEA--
GO:0007343 egg activation ISS17289678
GO:0035039 male pronucleus formation ISS17289678
About this table

Drugs & Compounds
for WBP2NL

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WBP2NL

Transcripts
for WBP2NL

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (WBP2NL)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152613

              Sigma-Aldrich siRNA for WBP2NL  
                     Sigma-Aldrich shRNA for WBP2NL  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_152613  

REFSEQ mRNAs for WBP2NL gene: 

NM_152613.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_152613  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_152613
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_152613
                                 untagged cDNA clone in CMV expression vector: NM_152613 

Additional cDNA sequence: 

AF393575.1 AK128138.1 AK129656.1 AK296138.1 AK310980.1 BC022546.1 BC022549.1 BC038789.1 
CR456400.1 

9 DOTS entries:

DT.92051558  DT.435469  DT.86843042  DT.100777208  DT.86858132  DT.120666535  DT.100737998  DT.100823590 
DT.403754 

24/214 AceView cDNA sequences (see all 214 ):

CR611488 AF285108 BX345218 AI369698 BQ937737 AW169980 CR616689 D54252 
BP348363 Z38211 NM_145734 CR456572 CR618252 N50539 BF528667 NM_019106 
BQ924462 BM666855 BE891766 AK128138 CR456400 CA388736 BM770133 BQ071318 

highest scoring ESTs for WBP2NL:

AI220013 AK129656 BC022546 BC022549 BM564167 CR456400 AA812559 AK128138 AW169980 BC038789 

Unigene Cluster for WBP2NL:

WBP2 N-terminal like
Hs.655541  [show with all ESTs]
Unigene Representative Sequence: AK128138


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for WBP2NL

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1:              -     -     -                                   -         
SP2:              -     -     -                                             
SP3:                                                                        

About this scheme

ECgene alternative splicing isoforms for WBP2NL

2 Ensembl transcripts including schematic representations:
ENST00000328823  ENST00000329620  

Expression
for WBP2NL

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WBP2NL expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for WBP2NL

1 / 2 / 3

4 probe-sets matching WBP2NL gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

76537_at2, 3 U95-D 1 1.00 1.00 1.00 1.00 AI220013 0.80 1.00 0.91 1

224738_x_at*2 U133-B 2 0.46 0.71 -- -- -- -- -- -- --

1552514_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

224738_x_at*2 U133Plus2 2 0.46 0.71 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.655541

UniProtKB/Swiss-Prot: WBP2L_HUMAN, Q6ICG8
Tissue specificity: Expressed in testis

Orthologs
for WBP2NL

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for WBP2NL gene from 3 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
cow
(Bos taurus)		 WBP2NL1   -- WBP2 N-terminal like 77.7(n)
66.23(a)		 523070  XM_601364.3  XP_601364.3 
rat
(Rattus norvegicus)		 Wbp2nl1   -- WBP2 N-terminal like 73.35(n)
65.05(a)		 688642  XM_001067725.1  XP_001067725.1 
mouse
(Mus musculus)		 Wbp2nl1, 5 155
 WBP2 N-terminal like1, 5 75.35(n)1
66.78(a)1		 747161  NM_029066.11  NP_083342.11 
 AK0158635  BC1195205 
About this table        Species with no ortholog for WBP2NL

ENSEMBL Gene Tree for WBP2NL

Paralogs
for WBP2NL

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for WBP2NL gene
WBP22  

SNPs/Variants
for WBP2NL

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/208 NCBI SNPs in WBP2NL are shown (see all 208 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 72)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 22 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs1333351,2
A,C,F,H,O40746002(+) TGGAGG/ATGCCA 1 D/G mis114Minor allele frequency- A:0.35EU EA WA NA 1432
rs1333471,2
A,C,F,O40753591(+) ACAAAT/ATGGAG 1 -- ut315Minor allele frequency- A:0.20EA NA 1700
rs170028081,2
C,F,H40753340(+) TGGCTA/GAAGGA 1 -- ut31 trp37Minor allele frequency- G:0.06NA EU EA WA 560
rs170028021,2
C,F,H40748301(+) GCCTTG/TTTCAG 1 C/F mis115Minor allele frequency- T:0.03NA EU EA WA 1396
rs23015211,2
C,F,H40753056(+) CCTCAC/GGAATC 1 H/Q mis1 ese313Minor allele frequency- G:0.18EA EU WA NA 2526
rs170028061,2
F,H40753217(+) GGTATG/ATGATC 1 -- ut317Minor allele frequency- A:0.03NA EU EA WA 558
rs170028091,2
F,H40753660(+) CAAAAC/ACAACA 1 -- ut317Minor allele frequency- A:0.06NA EU EA WA 562
rs170027901,2
F,H40724781(+) TGAATC/GAGAGC 1 Q/E mis1 ese37Minor allele frequency- G:0.04NA EU EA WA 562
rs97544851,2
H40753194(+) GTCAGG/AATAAG 1 -- ut31 ese34Minor allele frequency- A:0.00EU EA WA 418
rs1333031,2
A,C,F,H,O40725188(+) GGGGCG/CTTCGG 1 -- int18Minor allele frequency- C:0.42MN NA EU EA WA 742
About this table

HapMap Linkage Disequilibrium images for WBP2NL (up to first 250kb)

Disorders & Mutations
for WBP2NL

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 610981

Medical News
for WBP2NL

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for WBP2NL

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

7 PubMed articles for WBP2NL gene:

Search for WBP2NL

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing WBP2NL

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 164684 HGNC: 28389 AceView: SEPT3andMGC26816 Ensembl:ENSG00000183066 euGenes: HUgn164684
ECgene: WBP2NL H-InvDB: WBP2NL

Other Databases showing WBP2NL

(According to HUGE)
About This Section

   --

Specialized Databases showing WBP2NL

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for WBP2NL

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for WBP2NL

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for WBP2NL:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Lentivirus-delivered shRNAs for WBP2NL Browse small molecules at Sigma-Aldrich
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 Antibodies for WBP2NL

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