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Aliases for WBP2NL Gene

Aliases for WBP2NL Gene

  • WBP2 N-Terminal Like 2 3
  • PAWP 3 4 6
  • Postacrosomal Sheath WW Domain-Binding Protein 2 3
  • WW Domain-Binding Protein 2-Like 3 4

External Ids for WBP2NL Gene

Summaries for WBP2NL Gene

Entrez Gene Summary for WBP2NL Gene

  • WBP2NL is a sperm-specific WW domain-binding protein that promotes meiotic resumption and pronuclear development during oocyte fertilization (Wu et al., 2007 [PubMed 17289678]).[supplied by OMIM, Mar 2008]

GeneCards Summary for WBP2NL Gene

WBP2NL (WBP2 N-Terminal Like) is a Protein Coding gene. GO annotations related to this gene include WW domain binding. An important paralog of this gene is WBP2.

UniProtKB/Swiss-Prot for WBP2NL Gene

  • May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WBP2NL Gene

Genomics for WBP2NL Gene

Genomic Location for WBP2NL Gene

Start:
41,998,725 bp from pter
End:
42,058,456 bp from pter
Size:
59,732 bases
Orientation:
Plus strand

Genomic View for WBP2NL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WBP2NL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WBP2NL Gene

Regulatory Elements for WBP2NL Gene

Proteins for WBP2NL Gene

  • Protein details for WBP2NL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ICG8-WBP2L_HUMAN
    Recommended name:
    Postacrosomal sheath WW domain-binding protein
    Protein Accession:
    Q6ICG8
    Secondary Accessions:
    • A3KFF7
    • A8MSG5
    • B3KXX4
    • Q8TBF0
    • Q8TBF3

    Protein attributes for WBP2NL Gene

    Size:
    309 amino acids
    Molecular mass:
    31909 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH22549.1; Type=Frameshift; Positions=159; Evidence={ECO:0000305};

neXtProt entry for WBP2NL Gene

Proteomics data for WBP2NL Gene at MOPED

Post-translational modifications for WBP2NL Gene

No Post-translational modifications

Other Protein References for WBP2NL Gene

No data available for DME Specific Peptides for WBP2NL Gene

Domains for WBP2NL Gene

Protein Domains for WBP2NL Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

WBP2L_HUMAN
Domain:
  • Contains 1 GRAM domain.:
    • Q6ICG8
genes like me logo Genes that share domains with WBP2NL: view

No data available for Gene Families for WBP2NL Gene

Function for WBP2NL Gene

Molecular function for WBP2NL Gene

UniProtKB/Swiss-Prot Function: May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.

Gene Ontology (GO) - Molecular Function for WBP2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050699 WW domain binding ISS 17289678
genes like me logo Genes that share ontologies with WBP2NL: view

miRNA for WBP2NL Gene

miRTarBase miRNAs that target WBP2NL

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for WBP2NL Gene

Localization for WBP2NL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WBP2NL Gene COMPARTMENTS Subcellular localization image for WBP2NL gene
Compartment Confidence
cytoskeleton 3
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for WBP2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033011 perinuclear theca ISS 17289678
genes like me logo Genes that share ontologies with WBP2NL: view

Pathways for WBP2NL Gene

SuperPathways for WBP2NL Gene

No Data Available

Interacting Proteins for WBP2NL Gene

Gene Ontology (GO) - Biological Process for WBP2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007343 egg activation ISS 17289678
GO:0035039 male pronucleus assembly ISS 17289678
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with WBP2NL: view

No data available for Pathways by source for WBP2NL Gene

Transcripts for WBP2NL Gene

Unigene Clusters for WBP2NL Gene

WBP2 N-terminal like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WBP2NL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - -
SP3:

Relevant External Links for WBP2NL Gene

GeneLoc Exon Structure for
WBP2NL
ECgene alternative splicing isoforms for
WBP2NL

Expression for WBP2NL Gene

mRNA expression in normal human tissues for WBP2NL Gene

mRNA differential expression in normal tissues according to GTEx for WBP2NL Gene

This gene is overexpressed in Testis (21.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WBP2NL Gene

SOURCE GeneReport for Unigene cluster for WBP2NL Gene Hs.655541

mRNA Expression by UniProt/SwissProt for WBP2NL Gene

Q6ICG8-WBP2L_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expressions with WBP2NL: view

Orthologs for WBP2NL Gene

This gene was present in the common ancestor of animals.

Orthologs for WBP2NL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WBP2NL 36
  • 95.1 (n)
  • 91.26 (a)
WBP2NL 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WBP2NL 36
  • 78.3 (n)
  • 66.98 (a)
WBP2NL 37
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WBP2NL 36
  • 82.75 (n)
  • 73.53 (a)
WBP2NL 37
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wbp2nl 36
  • 75.87 (n)
  • 67.03 (a)
Wbp2nl 16
Wbp2nl 37
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WBP2NL 37
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WBP2NL 37
  • 34 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wbp2nl 36
  • 74.59 (n)
  • 65.03 (a)
chicken
(Gallus gallus)
Aves WBP2NL 37
  • 30 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WBP2NL 37
  • 36 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wbp2nl 37
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Wbp2 37
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C18B2.4 37
  • 25 (a)
ManyToMany
D2013.6 37
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2824 37
  • 26 (a)
OneToMany
Species with no ortholog for WBP2NL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for WBP2NL Gene

ENSEMBL:
Gene Tree for WBP2NL (if available)
TreeFam:
Gene Tree for WBP2NL (if available)

Paralogs for WBP2NL Gene

Paralogs for WBP2NL Gene

Selected SIMAP similar genes for WBP2NL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WBP2NL: view

Variants for WBP2NL Gene

Sequence variations from dbSNP and Humsavar for WBP2NL Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs129853 -- 42,002,371(+) tgaga(C/T)cagga intron-variant
rs129855 -- 42,003,321(+) AAGCA(A/G)TTGTG intron-variant
rs129856 -- 42,003,392(+) TTCCA(C/G)TTTTT intron-variant
rs129857 -- 42,003,682(+) aaata(C/T)gggtt intron-variant
rs133308 -- 42,001,465(+) ATCCC(A/G)TCAGA intron-variant

Relevant External Links for WBP2NL Gene

HapMap Linkage Disequilibrium report
WBP2NL

No data available for Structural Variations from Database of Genomic Variants (DGV) for WBP2NL Gene

Disorders for WBP2NL Gene

No disorders were found for WBP2NL Gene.

No data available for UniProtKB/Swiss-Prot for WBP2NL Gene

Publications for WBP2NL Gene

  1. PAWP, a sperm-specific WW domain-binding protein, promotes meiotic resumption and pronuclear development during fertilization. (PMID: 17289678) Wu A.T.H. … Oko R. (J. Biol. Chem. 2007) 2 3 4
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. (PMID: 24528284) Ji Y. … Weinshilboum R.M. (Br J Clin Pharmacol 2014) 3

Products for WBP2NL Gene

Sources for WBP2NL Gene

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