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Aliases for WBP2NL Gene

Aliases for WBP2NL Gene

  • WBP2 N-Terminal Like 2 3 5
  • Postacrosomal Sheath WW Domain-Binding Protein 2 3
  • WW Domain-Binding Protein 2-Like 3 4
  • PAWP 3 4
  • GRAMD7 3

External Ids for WBP2NL Gene

Previous GeneCards Identifiers for WBP2NL Gene

  • GC22P040724
  • GC22P042394
  • GC22P025360

Summaries for WBP2NL Gene

Entrez Gene Summary for WBP2NL Gene

  • WBP2NL is a sperm-specific WW domain-binding protein that promotes meiotic resumption and pronuclear development during oocyte fertilization (Wu et al., 2007 [PubMed 17289678]).[supplied by OMIM, Mar 2008]

GeneCards Summary for WBP2NL Gene

WBP2NL (WBP2 N-Terminal Like) is a Protein Coding gene. GO annotations related to this gene include WW domain binding. An important paralog of this gene is WBP2.

UniProtKB/Swiss-Prot for WBP2NL Gene

  • May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.

Additional gene information for WBP2NL Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WBP2NL Gene

Genomics for WBP2NL Gene

Regulatory Elements for WBP2NL Gene

Enhancers for WBP2NL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H042021 0.9 Ensembl ENCODE 33.2 +26.9 26946 2.4 ELF1 ZIC2 ZNF507 FOXK2 IKZF1 EED GLIS1 NFE2 IKZF2 SPI1 SMDT1 CYP2D6 WBP2NL SLC25A5P1 SEPT3 NAGA FAM109B PHF5A EP300 TOB2
GH22H041945 1.3 ENCODE dbSUPER 20.3 -48.4 -48417 2.7 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 FOS WBP2NL SMDT1 XRCC6 EP300 EP300-AS1 MEI1 SNU13 CENPM GC22P041949
GH22H041961 0.9 ENCODE 19.2 -34.3 -34255 0.2 ZNF493 ZFP64 ZEB1 ZNF302 ZNF138 SCRT2 ZNF654 SP3 ZNF680 ZC3H11A RN7SKP80 EP300 PHF5A POLDIP3 RPL5P34 NDUFA6 RRP7BP ENSG00000232754 XRCC6 ZC3H7B
GH22H041998 0.8 ENCODE 21.4 +3.5 3480 1.4 GTF2F1 HDGF PKNOX1 RB1 TAF1 MAX YY1 E2F1 ZNF121 POLR2A CYP2D6 WBP2NL NDUFA6-AS1 LOC102723706 SLC25A5P1
GH22H041957 1.1 Ensembl ENCODE 13.5 -37.4 -37380 1.1 HDGF ATF1 ARID4B RAD21 ZNF143 RUNX3 CREM THAP11 SMARCA5 HCFC1 WBP2NL SMDT1 LINC00634 GC22M042180
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WBP2NL on UCSC Golden Path with GeneCards custom track

Genomic Locations for WBP2NL Gene

Genomic Locations for WBP2NL Gene
64,229 bases
Plus strand

Genomic View for WBP2NL Gene

Genes around WBP2NL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WBP2NL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WBP2NL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WBP2NL Gene

Proteins for WBP2NL Gene

  • Protein details for WBP2NL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Postacrosomal sheath WW domain-binding protein
    Protein Accession:
    Secondary Accessions:
    • A3KFF7
    • A8MSG5
    • B3KXX4
    • Q8TBF0
    • Q8TBF3

    Protein attributes for WBP2NL Gene

    309 amino acids
    Molecular mass:
    31909 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH22549.1; Type=Frameshift; Positions=159; Evidence={ECO:0000305};

neXtProt entry for WBP2NL Gene

Post-translational modifications for WBP2NL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WBP2NL Gene

No data available for DME Specific Peptides for WBP2NL Gene

Domains & Families for WBP2NL Gene

Gene Families for WBP2NL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WBP2NL Gene


Suggested Antigen Peptide Sequences for WBP2NL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WBP2NL: view

No data available for UniProtKB/Swiss-Prot for WBP2NL Gene

Function for WBP2NL Gene

Molecular function for WBP2NL Gene

UniProtKB/Swiss-Prot Function:
May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.

Phenotypes From GWAS Catalog for WBP2NL Gene

Gene Ontology (GO) - Molecular Function for WBP2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050699 WW domain binding IEA,ISS 17289678
genes like me logo Genes that share ontologies with WBP2NL: view

Phenotypes for WBP2NL Gene

genes like me logo Genes that share phenotypes with WBP2NL: view

Animal Models for WBP2NL Gene

MGI Knock Outs for WBP2NL:

Animal Model Products

miRNA for WBP2NL Gene

miRTarBase miRNAs that target WBP2NL

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WBP2NL Gene

Localization for WBP2NL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WBP2NL gene
Compartment Confidence
cytoskeleton 4
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for WBP2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033011 perinuclear theca ISS,IEA 17289678
genes like me logo Genes that share ontologies with WBP2NL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for WBP2NL Gene

Pathways & Interactions for WBP2NL Gene

SuperPathways for WBP2NL Gene

No Data Available

Gene Ontology (GO) - Biological Process for WBP2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007343 egg activation ISS 17289678
GO:0035038 female pronucleus assembly IEA --
GO:0035039 male pronucleus assembly ISS,IEA 17289678
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with WBP2NL: view

No data available for Pathways by source and SIGNOR curated interactions for WBP2NL Gene

Drugs & Compounds for WBP2NL Gene

No Compound Related Data Available

Transcripts for WBP2NL Gene

Unigene Clusters for WBP2NL Gene

WBP2 N-terminal like:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for WBP2NL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - -

Relevant External Links for WBP2NL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WBP2NL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WBP2NL Gene

mRNA differential expression in normal tissues according to GTEx for WBP2NL Gene

This gene is overexpressed in Testis (x21.7).

Protein differential expression in normal tissues from HIPED for WBP2NL Gene

This gene is overexpressed in Pancreas (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WBP2NL Gene

Protein tissue co-expression partners for WBP2NL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WBP2NL Gene:


SOURCE GeneReport for Unigene cluster for WBP2NL Gene:


mRNA Expression by UniProt/SwissProt for WBP2NL Gene:

Tissue specificity: Expressed in testis.

Evidence on tissue expression from TISSUES for WBP2NL Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with WBP2NL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for WBP2NL Gene

Orthologs for WBP2NL Gene

This gene was present in the common ancestor of animals.

Orthologs for WBP2NL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WBP2NL 33 34
  • 95.1 (n)
(Canis familiaris)
Mammalia WBP2NL 33 34
  • 82.75 (n)
(Bos Taurus)
Mammalia WBP2NL 33 34
  • 78.3 (n)
(Mus musculus)
Mammalia Wbp2nl 33 16 34
  • 75.87 (n)
(Rattus norvegicus)
Mammalia Wbp2nl 33
  • 74.59 (n)
(Monodelphis domestica)
Mammalia WBP2NL 34
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia WBP2NL 34
  • 34 (a)
(Gallus gallus)
Aves WBP2NL 34
  • 30 (a)
(Anolis carolinensis)
Reptilia WBP2NL 34
  • 36 (a)
(Danio rerio)
Actinopterygii wbp2nl 34
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta Wbp2 34
  • 21 (a)
(Caenorhabditis elegans)
Secernentea C18B2.4 34
  • 25 (a)
D2013.6 34
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2824 34
  • 26 (a)
Species where no ortholog for WBP2NL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for WBP2NL Gene

Gene Tree for WBP2NL (if available)
Gene Tree for WBP2NL (if available)

Paralogs for WBP2NL Gene

Paralogs for WBP2NL Gene

(1) SIMAP similar genes for WBP2NL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WBP2NL: view

Variants for WBP2NL Gene

Sequence variations from dbSNP and Humsavar for WBP2NL Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs80313011 Likely benign 42,058,465(+) CTTGC(A/G)TCCAA downstream-variant-500B, utr-variant-3-prime
rs10713176 Uncertain significance 42,058,490(+) AACTG(-/A)AAAAA downstream-variant-500B, utr-variant-3-prime
rs11703233 Uncertain significance 42,058,583(+) GAAGG(A/G)TGAAG downstream-variant-500B, utr-variant-3-prime
rs750373836 Uncertain significance 42,058,778(+) AGAAG(C/G)TGTTC downstream-variant-500B, utr-variant-3-prime
rs1063392 Benign 42,058,946(-) AAGTA(C/T)AGGGT downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WBP2NL Gene

Variant ID Type Subtype PubMed ID
nsv964636 CNV duplication 23825009

Variation tolerance for WBP2NL Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.35; 70.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WBP2NL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WBP2NL Gene

Disorders for WBP2NL Gene

Relevant External Links for WBP2NL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WBP2NL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WBP2NL Gene

Publications for WBP2NL Gene

  1. PAWP, a sperm-specific WW domain-binding protein, promotes meiotic resumption and pronuclear development during fertilization. (PMID: 17289678) Wu AT … Oko R (The Journal of biological chemistry 2007) 2 3 4 60
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP. (PMID: 26721930) Escoffier J … Arnoult C (Human molecular genetics 2016) 3 60
  5. The Evaluation of WBP2NL-Related Genes Expression in Breast Cancer. (PMID: 25417742) Nourashrafeddin S … Nouri M (Pathology oncology research : POR 2015) 3 60

Products for WBP2NL Gene

Sources for WBP2NL Gene

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