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Aliases for WBP2NL Gene

Aliases for WBP2NL Gene

  • WBP2 N-Terminal Like 2 3 5
  • WW Domain-Binding Protein 2-Like 3 4
  • PAWP 3 4
  • Postacrosomal Sheath WW Domain-Binding Protein 2
  • GRAMD7 3

External Ids for WBP2NL Gene

Previous GeneCards Identifiers for WBP2NL Gene

  • GC22P040724
  • GC22P042394
  • GC22P025360

Summaries for WBP2NL Gene

Entrez Gene Summary for WBP2NL Gene

  • WBP2NL is a sperm-specific WW domain-binding protein that promotes meiotic resumption and pronuclear development during oocyte fertilization (Wu et al., 2007 [PubMed 17289678]).[supplied by OMIM, Mar 2008]

GeneCards Summary for WBP2NL Gene

WBP2NL (WBP2 N-Terminal Like) is a Protein Coding gene. GO annotations related to this gene include WW domain binding. An important paralog of this gene is WBP2.

UniProtKB/Swiss-Prot for WBP2NL Gene

  • May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WBP2NL Gene

Genomics for WBP2NL Gene

Regulatory Elements for WBP2NL Gene

Enhancers for WBP2NL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WBP2NL on UCSC Golden Path with GeneCards custom track

Genomic Location for WBP2NL Gene

41,995,346 bp from pter
42,059,574 bp from pter
64,229 bases
Plus strand

Genomic View for WBP2NL Gene

Genes around WBP2NL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WBP2NL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WBP2NL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WBP2NL Gene

Proteins for WBP2NL Gene

  • Protein details for WBP2NL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Postacrosomal sheath WW domain-binding protein
    Protein Accession:
    Secondary Accessions:
    • A3KFF7
    • A8MSG5
    • B3KXX4
    • Q8TBF0
    • Q8TBF3

    Protein attributes for WBP2NL Gene

    309 amino acids
    Molecular mass:
    31909 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH22549.1; Type=Frameshift; Positions=159; Evidence={ECO:0000305};

neXtProt entry for WBP2NL Gene

Proteomics data for WBP2NL Gene at MOPED

Post-translational modifications for WBP2NL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WBP2NL Gene

No data available for DME Specific Peptides for WBP2NL Gene

Domains & Families for WBP2NL Gene

Gene Families for WBP2NL Gene

Protein Domains for WBP2NL Gene

Suggested Antigen Peptide Sequences for WBP2NL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GRAM domain.
  • Contains 1 GRAM domain.
genes like me logo Genes that share domains with WBP2NL: view

Function for WBP2NL Gene

Molecular function for WBP2NL Gene

UniProtKB/Swiss-Prot Function:
May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.

Phenotypes for WBP2NL Gene

genes like me logo Genes that share phenotypes with WBP2NL: view

Animal Model Products

CRISPR Products

miRNA for WBP2NL Gene

miRTarBase miRNAs that target WBP2NL

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WBP2NL Gene

Localization for WBP2NL Gene

Subcellular locations from

Jensen Localization Image for WBP2NL Gene COMPARTMENTS Subcellular localization image for WBP2NL gene
Compartment Confidence
cytoskeleton 3
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WBP2NL Gene

Pathways & Interactions for WBP2NL Gene

SuperPathways for WBP2NL Gene

No Data Available

Interacting Proteins for WBP2NL Gene

Gene Ontology (GO) - Biological Process for WBP2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with WBP2NL: view

No data available for Pathways by source and SIGNOR curated interactions for WBP2NL Gene

Drugs & Compounds for WBP2NL Gene

No Compound Related Data Available

Transcripts for WBP2NL Gene

Unigene Clusters for WBP2NL Gene

WBP2 N-terminal like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WBP2NL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - -

Relevant External Links for WBP2NL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WBP2NL Gene

mRNA expression in normal human tissues for WBP2NL Gene

mRNA differential expression in normal tissues according to GTEx for WBP2NL Gene

This gene is overexpressed in Testis (x21.7).

Protein differential expression in normal tissues from HIPED for WBP2NL Gene

This gene is overexpressed in Pancreas (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WBP2NL Gene

SOURCE GeneReport for Unigene cluster for WBP2NL Gene Hs.655541

mRNA Expression by UniProt/SwissProt for WBP2NL Gene

Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with WBP2NL: view

Protein tissue co-expression partners for WBP2NL Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for WBP2NL Gene

Orthologs for WBP2NL Gene

This gene was present in the common ancestor of animals.

Orthologs for WBP2NL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WBP2NL 35
  • 78.3 (n)
  • 66.98 (a)
  • 61 (a)
(Canis familiaris)
Mammalia WBP2NL 35
  • 82.75 (n)
  • 73.53 (a)
  • 60 (a)
(Mus musculus)
Mammalia Wbp2nl 35
  • 75.87 (n)
  • 67.03 (a)
Wbp2nl 16
Wbp2nl 36
  • 50 (a)
(Pan troglodytes)
Mammalia WBP2NL 35
  • 95.1 (n)
  • 91.26 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Wbp2nl 35
  • 74.59 (n)
  • 65.03 (a)
(Monodelphis domestica)
Mammalia WBP2NL 36
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia WBP2NL 36
  • 34 (a)
(Gallus gallus)
Aves WBP2NL 36
  • 30 (a)
(Anolis carolinensis)
Reptilia WBP2NL 36
  • 36 (a)
(Danio rerio)
Actinopterygii wbp2nl 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta Wbp2 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea C18B2.4 36
  • 25 (a)
D2013.6 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2824 36
  • 26 (a)
Species with no ortholog for WBP2NL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for WBP2NL Gene

Gene Tree for WBP2NL (if available)
Gene Tree for WBP2NL (if available)

Paralogs for WBP2NL Gene

Paralogs for WBP2NL Gene

(1) SIMAP similar genes for WBP2NL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WBP2NL: view

Variants for WBP2NL Gene

Sequence variations from dbSNP and Humsavar for WBP2NL Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_032578 -
rs133335 - 42,020,052(+) TGGAG(A/G)TGCCA nc-transcript-variant, reference, missense
rs17002802 - 42,022,351(+) GCCTT(G/T)TTCAG nc-transcript-variant, reference, missense
rs2301521 - 42,027,106(+) CCTCA(C/G)GAATC nc-transcript-variant, reference, missense
rs129853 -- 42,002,371(+) tgaga(C/T)cagga intron-variant

Variation tolerance for WBP2NL Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.35; 70.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for WBP2NL Gene

Disorders for WBP2NL Gene

Relevant External Links for WBP2NL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WBP2NL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WBP2NL Gene

Publications for WBP2NL Gene

  1. PAWP, a sperm-specific WW domain-binding protein, promotes meiotic resumption and pronuclear development during fertilization. (PMID: 17289678) Wu A.T.H. … Oko R. (J. Biol. Chem. 2007) 2 3 4 67
  2. The Evaluation of WBP2NL-Related Genes Expression in Breast Cancer. (PMID: 25417742) Nourashrafeddin S. … Nouri M. (Pathol. Oncol. Res. 2015) 3
  3. PLCIP or PAWP: revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis. (PMID: 25722320) Kashir J. … Lai F.A. (Mol. Hum. Reprod. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. (PMID: 24528284) Ji Y. … Weinshilboum R.M. (Br J Clin Pharmacol 2014) 3

Products for WBP2NL Gene

Sources for WBP2NL Gene