Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WBP2 Gene

protein-coding   GIFtS: 54
GCID: GC17M073841

WW Domain Binding Protein 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WW Domain Binding Protein 21 2
WBP-22 3
WW Domain-Binding Protein 22

External Ids:    HGNC: 127381   Entrez Gene: 235582   Ensembl: ENSG000001324717   OMIM: 6069625   UniProtKB: Q969T93   

Export aliases for WBP2 gene to outside databases

Previous GC identifers: GC17M073818 GC17M076868 GC17M074305 GC17M074438 GC17M071353 GC17M069267


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WBP2 Gene:
The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions
including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein
interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which
binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not
been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for WBP2 Gene: 
WBP2 (WW domain binding protein 2) is a protein-coding gene. Diseases associated with WBP2 include thyroiditis. GO annotations related to this gene include protein binding. An important paralog of this gene is WBP2NL.

Gene Wiki entry for WBP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WBP2 gene promoter:
         E2F-3a   E2F-4   GR   E2F-5   p53   GR-beta   E2F-2   E2F   E2F-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWBP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for WBP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25

WBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WBP2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M073841:  view genomic region     (about GC identifiers)

Start:
73,841,780 bp from pter      End:
73,852,588 bp from pter
Size:
10,809 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WBP2_HUMAN, Q969T9 (See protein sequence)
Recommended Name: WW domain-binding protein 2  
Size: 261 amino acids; 28087 Da
Subunit: Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with NEDD4 (By similarity)
Sequence caution: Sequence=AAD10951.1; Type=Erroneous initiation;
Secondary accessions: O95638

Explore the universe of human proteins at neXtProt for WBP2: NX_Q969T9

Explore proteomics data for WBP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q969T9

  • WBP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WBP2 Protein Expression
    REFSEQ proteins: NP_036610.2  
    ENSEMBL proteins: 
     ENSP00000467583   ENSP00000467579   ENSP00000466999   ENSP00000466450   ENSP00000464782  
     ENSP00000465052   ENSP00000415251   ENSP00000468793   ENSP00000464820   ENSP00000464768  
     ENSP00000254806   ENSP00000341570  

    Human Recombinant Protein Products for WBP2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for WBP2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for WBP2
    GenScript Custom Purified and Recombinant Proteins Services for WBP2
    Novus Biologicals WBP2 Proteins
    Novus Biologicals WBP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for WBP2
    Cloud-Clone Corp. Proteins for WBP2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    WBP2 for ontologies           About GeneDecksing



    WBP2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for WBP2 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for WBP2
    GenScript Custom Superior Antibodies Services for WBP2
    Novus Biologicals WBP2 Antibodies
    Abcam antibodies for WBP2
    Cloud-Clone Corp. Antibodies for WBP2 
    ThermoFisher Antibodies for WBP2
    LSBio Antibodies in human, mouse, rat for WBP2 

    Assay Products for WBP2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for WBP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WBP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WBP2 
    Cloud-Clone Corp. CLIAs for WBP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR018826 WW-domain-binding
     IPR004182 GRAM

    Graphical View of Domain Structure for InterPro Entry Q969T9

    ProtoNet protein and cluster: Q969T9

    UniProtKB/Swiss-Prot: WBP2_HUMAN, Q969T9
    Domain: The WW-binding 1 motif mediates interaction with NEDD4 (By similarity)
    Similarity: Contains 1 GRAM domain


    WBP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    WBP2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for WBP2:
     Decreased POU5F1-GFP protein e  Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WBP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WBP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WBP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WBP2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WBP2
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate WBP2 (see all 26):
    hsa-miR-582-3p hsa-miR-1288 hsa-miR-629 hsa-miR-320e hsa-miR-7-1* hsa-miR-889 hsa-miR-205* hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidWBP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for WBP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WBP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WBP2
    Sirion Biotech Customized adenovirus for overexpression of WBP2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for WBP2 (see all 8)
    OriGene ORF clones in mouse, rat for WBP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WBP2 (NM_012478)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WBP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WBP2
    Sirion Biotech Customized lentivirus for stable overexpression of WBP2 
                         Customized lentivirus expression plasmids for stable overexpression of WBP2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for WBP2
    Search LifeMap BioReagents cell lines for WBP2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WBP2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Tyrosine Kinases / Adaptors
    Tyrosine Kinases / Adaptors
    2Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for WBP2
        Wnt / Hedgehog / Notch
    Tyrosine Kinases / Adaptors



    WBP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WBP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/18 Interacting proteins for WBP2 (Q969T91, 2, 3 ENSP000002548064) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WWOXQ9NZC72, 3, ENSP000003861614MINT-72786 I2D: score=3 STRING: ENSP00000386161
    SEPT3Q9UH032, 3, ENSP000003797044MINT-65566 I2D: score=4 STRING: ENSP00000379704
    CLEC4GQ6UXB43, ENSP000003275994I2D: score=2 STRING: ENSP00000327599
    ITCHQ96J023, ENSP000003639984I2D: score=2 STRING: ENSP00000363998
    WWP2O003083, ENSP000003482834I2D: score=1 STRING: ENSP00000348283
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    WBP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WBP2

    Search CenterWatch for drugs/clinical trials and news about WBP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WBP2 gene: 
    NM_012478.3  

    Unigene Cluster for WBP2:

    WW domain binding protein 2
    Hs.514489  [show with all ESTs]
    Unigene Representative Sequence: NM_012478
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000585462 ENST00000591399 ENST00000587642 ENST00000591831 ENST00000590221
    ENST00000586257 ENST00000588373 ENST00000433525 ENST00000589236 ENST00000416574(uc010wsn.1)
    ENST00000589642 ENST00000587374 ENST00000593002 ENST00000589241 ENST00000590450
    ENST00000589834 ENST00000592802 ENST00000254806(uc002jps.3 uc010wsl.2 uc010wsm.2)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WBP2
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate WBP2 (see all 26):
    hsa-miR-582-3p hsa-miR-1288 hsa-miR-629 hsa-miR-320e hsa-miR-7-1* hsa-miR-889 hsa-miR-205* hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidWBP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for WBP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WBP2
    Clone
    Products:
         
    OriGene clones in human, mouse for WBP2 (see all 8)
    OriGene ORF clones in mouse, rat for WBP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WBP2 (NM_012478)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WBP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WBP2
    Sirion Biotech Customized lentivirus for stable overexpression of WBP2 
                         Customized lentivirus expression plasmids for stable overexpression of WBP2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for WBP2
    OriGene qSTAR qPCR primer pairs in human, mouse for WBP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WBP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WBP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WBP2

    Additional mRNA sequence: 

    AF087866.1 AK057881.1 AK293214.1 AK294082.1 AK294155.1 AK300875.1 AL049981.1 BC007452.1 
    BC010616.1 

    24/56 DOTS entries (see all 56):

    DT.100059670  DT.95104877  DT.100684438  DT.95104864  DT.87017337  DT.91902613  DT.120904247  DT.91653807 
    DT.100684442  DT.120904262  DT.92458766  DT.101985363  DT.120904344  DT.100059669  DT.95104803  DT.120904210 
    DT.40230571  DT.100684418  DT.100684424  DT.100684431  DT.40133598  DT.95104822  DT.120904201  DT.120904227 

    24/958 AceView cDNA sequences (see all 958):

    CB129363 CR609382 CR616842 BC010616 CB125504 AA284506 BF725279 CB138318 
    BM474566 BP333999 BU178664 BM564475 T30042 Z39805 NM_012478 AW262785 
    CB144432 CR602003 BQ647329 BM996217 CR613461 BI816783 AW131694 AI815598 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for WBP2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                          -                 -           -     -                 -     -     -                                                         
    SP2:                          -                 -           -     -           -     -     -     -     -     -     -     -                                 
    SP3:                          -           -     -           -     -                                                                                       
    SP4:                          -                 -           -                                                                                             
    SP5:                                            -           -     -                 -     -     -                                                         


    ECgene alternative splicing isoforms for WBP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTGAGGAG
    WBP2 Expression
    About this image


    See WBP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WBP2

    SOURCE GeneReport for Unigene cluster: Hs.514489

    UniProtKB/Swiss-Prot: WBP2_HUMAN, Q969T9
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for WBP2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for WBP2
    OriGene qSTAR qPCR primer pairs in human, mouse for WBP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WBP2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WBP2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WBP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WBP2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wbp21 , 5 WW domain binding protein 21, 5 91.06(n)1
    96.93(a)1
      11 (80.91 cM)5
    223781  NM_016852.21  NP_058548.11 
     1160785735 
    chicken
    (Gallus gallus)
    Aves WBP21 WW domain binding protein 2 77.52(n)
    83.14(a)
      417368  XM_415626.3  XP_415626.2 
    lizard
    (Anolis carolinensis)
    Reptilia WBP26
    Uncharacterized protein
    81(a)
    1 ↔ 1
    2(113471926-113493453)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687432 hypothetical protein MGC68743 75.04(n)    BC060358.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC053232.12   -- 76.08(n)   325287  BC053232.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG110091 CG11009 49.18(n)
    41.8(a)
      39460  NM_140350.3  NP_648607.2 
    worm
    (Caenorhabditis elegans)
    Secernentea C18B2.41 Protein C18B2.4 46.89(n)
    36.51(a)
      180652  NM_076219.6  NP_508620.1 


    ENSEMBL Gene Tree for WBP2 (if available)
    TreeFam Gene Tree for WBP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WBP2 gene
    WBP2NL2  
    2 SIMAP similar genes for WBP2 using alignment to 11 protein entries:     WBP2_HUMAN (see all proteins):
    DKFZp564D012    WBP2NL

    WBP2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for WBP2
    PGOHUM00000242181 PGOHUM00000239401 PGOHUM00000234902


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/330 SNPs in WBP2 are shown (see all 330)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1995184151,2
    --73842860(+) GGCGGC/TGGCTG 2 P syn10--------
    rs2016666161,2
    --73842869(+) TGGCTC/TTAAAG 1 -- spa10--------
    rs23059141,2
    C,F,A,H--73842892(-) TGCAAG/ATCTCT 1 -- int123Minor allele frequency- A:0.30EA NS NA WA CSA EU 4044
    rs1391643831,2
    --73842925(+) CGGTCA/TTCCCC 1 -- int10--------
    rs1115856351,2
    C--73842987(+) CTCTCA/C/TCCGTG 1 -- spd11CSA 1
    rs2005341751,2
    --73842996(+) TGGGCA/GTGTAG 2 T M mis10--------
    rs1390175981,2
    C,F--73842998(+) GGCATG/ATAGAC 2 /Y syn11Minor allele frequency- A:0.00NA 4550
    rs1998978771,2
    C--73843003(+) GTAGAC/TGTTGT 2 I V mis10--------
    rs351719471,2
    C,F--73843040(+) CTGGCG/AGCTGC 2 /A syn15Minor allele frequency- A:0.02NA WA EA EU 6179
    rs1124027111,2
    C,F--73843182(+) CACCAA/GTGAGA 1 -- int13Minor allele frequency- G:0.14CSA WA 122

    HapMap Linkage Disequilibrium report for WBP2 (73841780 - 73852588 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for WBP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv908804CNV Loss21882294
    nsv908820CNV Loss21882294
    dgv3268n71CNV Loss21882294
    dgv3267n71CNV Loss21882294
    nsv470606CNV Loss18288195
    nsv510728CNV Loss20534489
    dgv3264n71CNV Loss21882294
    nsv908821CNV Loss21882294
    nsv833545CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing WBP2
    DNA2.0 Custom Variant and Variant Library Synthesis for WBP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606962    OMIM disorders: --

    2 diseases for WBP2:    About MalaCards
    thyroiditis    


    WBP2 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: WBP2 (1 document)

    Export disorders for WBP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WBP2 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with WBP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands. (PubMed id 9202023)1, 2 Chen H.I.... Sudol M. (1997)
    3. Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PubMed id 9169421)1, 2 Pirozzi G.... Fowlkes D.M. (1997)
    4. The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. (PubMed id 7644498)1, 3 Chen H.I. and Sudol M. (1995)
    5. WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. (PubMed id 16772533)1, 9 Dhananjayan S.C....Nawaz Z. (2006)
    6. Molecular mechanism of WW-domain binding protein-2 coa ctivation function in estrogen receptor signaling. (PubMed id 23233354)1 Buffa L....Nawaz Z. (2013)
    7. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23558 HGNC: 12738 AceView: WBP2 Ensembl:ENSG00000132471 euGenes: HUgn23558
    ECgene: WBP2 H-InvDB: WBP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WBP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WBP2 gene:
    Search GeneIP for patents involving WBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for WBP2  
     OriGene qPCR primer pairs and template standards for WBP2   OriGene Protein Over-expression Lysate for WBP2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for WBP2  
     OriGene qSTAR qPCR primer pairs in human, mouse for WBP2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for WBP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for WBP2   OriGene Custom Protein Services for WBP2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WBP2
     QIAGEN SeqTarget long-range PCR primers for resequencing WBP2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WBP2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WBP2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WBP2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WBP2
     GenScript Custom Purified and Recombinant Proteins Services for WBP2 GenScript cDNA clones with any tag delivered in your preferred vector for WBP2
     GenScript Custom Assay Services for WBP2 GenScript Custom Superior Antibodies Services for WBP2
     GenScript Custom overexpressing Cell Line Services for WBP2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for WBP2 

     Regulatory tfbs in WBP2 promoter
     Search Chromatin IP Primers for WBP2
     RT2 qPCR Primer Assay in human, mouse, rat WBP2
     GNC Network for WBP2
     SABiosciences Custom PCR Arrays for WBP2
     Search Tocris compounds for WBP2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     WBP2 antibodies
     WBP2 proteins
     WBP2 lysates
     Antibodies for WBP2
     See all of Abcam's Antibodies, Kits and Proteins for WBP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for WBP2




     Proteins for WBP2
     Antibodies for WBP2
     ELISAs for WBP2
     CLIAs for WBP2
     Search LifeMap BioReagents cell lines for WBP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP2
     SwitchGear 3'UTR luciferase reporter plasmids for WBP2
     SwitchGear Promoter luciferase reporter plasmids for WBP2
     ThermoFisher Antibodies for WBP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WBP2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for WBP2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WBP2
    Customized:
     lentivirus for stable overexpression of WBP2
     lentivirus expression plasmids for stable overexpression of WBP2
     adenovirus for overexpression of WBP2
     LSBio Antibodies in human, mouse, rat for WBP2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      WBP2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4