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Aliases for WBP2 Gene

Aliases for WBP2 Gene

  • WW Domain Binding Protein 2 2 3
  • WBP-2 3 4
  • WW Domain-Binding Protein 2 3

External Ids for WBP2 Gene

Summaries for WBP2 Gene

Entrez Gene Summary for WBP2 Gene

  • The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for WBP2 Gene

WBP2 (WW Domain Binding Protein 2) is a Protein Coding gene. Among its related pathways are Tyrosine Kinases / Adaptors and Wnt / Hedgehog / Notch. An important paralog of this gene is WBP2NL.

Gene Wiki entry for WBP2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WBP2 Gene

Genomics for WBP2 Gene

Genomic Location for WBP2 Gene

Start:
75,845,699 bp from pter
End:
75,856,507 bp from pter
Size:
10,809 bases
Orientation:
Minus strand

Genomic View for WBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WBP2 Gene

Regulatory Elements for WBP2 Gene

Proteins for WBP2 Gene

  • Protein details for WBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969T9-WBP2_HUMAN
    Recommended name:
    WW domain-binding protein 2
    Protein Accession:
    Q969T9
    Secondary Accessions:
    • O95638

    Protein attributes for WBP2 Gene

    Size:
    261 amino acids
    Molecular mass:
    28087 Da
    Quaternary structure:
    • Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with NEDD4 (By similarity).
    SequenceCaution:
    • Sequence=AAD10951.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WBP2 Gene

Proteomics data for WBP2 Gene at MOPED

Post-translational modifications for WBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WBP2 Gene

Domains for WBP2 Gene

Protein Domains for WBP2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q969T9

UniProtKB/Swiss-Prot:

WBP2_HUMAN
Domain:
  • The WW-binding 1 motif mediates interaction with NEDD4.:
    • Q969T9
  • Contains 1 GRAM domain.:
    • Q969T9
genes like me logo Genes that share domains with WBP2: view

No data available for Gene Families for WBP2 Gene

Function for WBP2 Gene

Gene Ontology (GO) - Molecular Function for WBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IMP 23233354
GO:0001105 RNA polymerase II transcription coactivator activity IMP 23233354
GO:0005515 protein binding IPI 20972459
GO:0031490 chromatin DNA binding IMP 23233354
genes like me logo Genes that share ontologies with WBP2: view
genes like me logo Genes that share phenotypes with WBP2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WBP2 Gene

Localization for WBP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WBP2 Gene COMPARTMENTS Subcellular localization image for WBP2 gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for WBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 23233354
genes like me logo Genes that share ontologies with WBP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WBP2 Gene

Pathways for WBP2 Gene

genes like me logo Genes that share pathways with WBP2: view

Pathways by source for WBP2 Gene

2 Cell Signaling Technology pathways for WBP2 Gene

Gene Ontology (GO) - Biological Process for WBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045184 establishment of protein localization IMP 23233354
GO:0045815 positive regulation of gene expression, epigenetic IMP 23233354
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP 23233354
GO:0071391 cellular response to estrogen stimulus IMP 23233354
GO:0071442 positive regulation of histone H3-K14 acetylation IMP 23233354
genes like me logo Genes that share ontologies with WBP2: view

Transcripts for WBP2 Gene

Unigene Clusters for WBP2 Gene

WW domain binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WBP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - -
SP6:
SP7: - -
SP8: - - - - - -
SP9:
SP10:
SP11: -

Relevant External Links for WBP2 Gene

GeneLoc Exon Structure for
WBP2
ECgene alternative splicing isoforms for
WBP2

Expression for WBP2 Gene

mRNA expression in normal human tissues for WBP2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WBP2 Gene

SOURCE GeneReport for Unigene cluster for WBP2 Gene Hs.514489

mRNA Expression by UniProt/SwissProt for WBP2 Gene

Q969T9-WBP2_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with WBP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WBP2 Gene

Orthologs for WBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for WBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WBP2 35
  • 99.8 (n)
  • 100 (a)
WBP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WBP2 35
  • 91.06 (n)
  • 96.17 (a)
WBP2 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WBP2 35
  • 92.46 (n)
  • 97.7 (a)
WBP2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wbp2 35
  • 91.06 (n)
  • 96.93 (a)
Wbp2 16
Wbp2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Wbp2 35
  • 88.63 (n)
  • 94.25 (a)
chicken
(Gallus gallus)
Aves WBP2 35
  • 74.93 (n)
  • 80.31 (a)
WBP2 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WBP2 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68743 35
tropical clawed frog
(Silurana tropicalis)
Amphibia wbp2 35
  • 67.44 (n)
  • 66.02 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
wbp2 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Wbp2 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C18B2.4 36
  • 32 (a)
ManyToMany
D2013.6 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2824 36
  • 40 (a)
OneToMany
Species with no ortholog for WBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WBP2 Gene

ENSEMBL:
Gene Tree for WBP2 (if available)
TreeFam:
Gene Tree for WBP2 (if available)

Paralogs for WBP2 Gene

Paralogs for WBP2 Gene

Pseudogenes.org Pseudogenes for WBP2 Gene

genes like me logo Genes that share paralogs with WBP2: view

Variants for WBP2 Gene

Sequence variations from dbSNP and Humsavar for WBP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs936391 -- 75,851,718(-) CGTCT(C/T)CATAC intron-variant
rs936392 -- 75,851,717(-) GTCTC(C/T)ATACT intron-variant
rs936393 -- 75,851,532(-) AGGCT(C/T)GTTGC intron-variant
rs936394 -- 75,855,927(+) TCTCA(A/C)CACTC upstream-variant-2KB
rs936395 -- 75,856,035(+) CCCTC(C/G)CAGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WBP2 Gene

Variant ID Type Subtype PubMed ID
dgv3264n71 CNV Loss 21882294
nsv908804 CNV Loss 21882294
dgv3267n71 CNV Loss 21882294
dgv3268n71 CNV Loss 21882294
nsv833545 CNV Gain 17160897
nsv470606 CNV Loss 18288195
nsv908820 CNV Loss 21882294
nsv510728 CNV Loss 20534489
nsv908821 CNV Loss 21882294

Relevant External Links for WBP2 Gene

HapMap Linkage Disequilibrium report
WBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WBP2 Gene

Disorders for WBP2 Gene

Relevant External Links for WBP2

Human Genome Epidemiology (HuGE) Navigator
WBP2
genes like me logo Genes that share disorders with WBP2: view

No data available for UniProtKB/Swiss-Prot for WBP2 Gene

Publications for WBP2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. (PMID: 16772533) Dhananjayan S.C. … Nawaz Z. (Mol. Endocrinol. 2006) 3 23
  3. The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. (PMID: 7644498) Chen H.I. … Sudol M. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3
  4. Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PMID: 9169421) Pirozzi G. … Fowlkes D.M. (J. Biol. Chem. 1997) 3 4
  5. Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands. (PMID: 9202023) Chen H.I. … Sudol M. (J. Biol. Chem. 1997) 3 4

Products for WBP2 Gene

  • Addgene plasmids for WBP2

Sources for WBP2 Gene

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