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Aliases & Descriptions for WBP2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MGC18269 2 | | WBP-2 1, 2, 3 |
| | | Descriptions |
|---|
| WW domain binding protein 2 2 |
|
| | Search outside databases for aliases for WBP2 genePrevious GC identifers: GC17M073818 GC17M076868 GC17M074305 GC17M074438 |
Summaries for WBP2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for WBP2: The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined. [provided by RefSeq] Gene Wiki entry for WBP2 |
Genomic Location for WBP2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the WBP2 gene 
Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25WBP2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M071353:
(about GC identifiers)
Start:
|
71,353,375 bp from pter |
End:
|
71,363,096 bp from pter |
Size:
|
9,722 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010641.15
| Proteins for WBP2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: WBP2_HUMAN, Q969T9 (See
protein sequence)Recommended Name: WW domain-binding protein 2 Size: 261 amino acids; 28087 Da
Subunit: Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with NEDD4 (By similarity)
Secondary accessions: O95638Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_036610.2
ENSEMBL proteins: ENSP00000254806
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: WBP2 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | About this table
Antibodies for WBP2: Assays for WBP2: | Protein
Domains/ Families for WBP2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q969T9
ProtoNet protein and cluster: Q969T9 UniProtKB/Swiss-Prot: WBP2_HUMAN, Q969T9Domain: The WW-binding 1 motif mediates interaction with NEDD4 (By similarity)Similarity: Contains 1 GRAM domain | Gene Function for WBP2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012478
Applied Biosystems Silencer® siRNAs for WBP2
Sigma-Aldrich siRNA for WBP2  Sigma-Aldrich shRNA for WBP2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012478                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012478                                  untagged cDNA clones in CMV expression vector (see all 3): AL049981 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_012478
1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for WBP2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for WBP2 
5/6 Interacting proteins for WBP2 (ENSP000002548063 Q969T92) via UniProtKB, MINT, and/or STRING (see all 6
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | About this table
|
Drugs & Compounds for WBP2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for WBP2
|
Transcripts for WBP2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012478
Sigma-Aldrich siRNA for WBP2  Sigma-Aldrich shRNA for WBP2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_012478 REFSEQ mRNAs for WBP2 gene: NM_012478.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_012478               OriGene GFP tagged cDNA clone in CMV expression vector: NM_012478                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012478                                  untagged cDNA clones in CMV expression vector (see all 3): AL049981  Additional cDNA sequence: AF087866.1 AK057881.1 AK293214.1 AK294082.1 AK294155.1 AK300875.1 AL049981.1 BC007452.1 BC010616.1 CR590489.1 CR596623.1 CR597688.1 CR597715.1 CR597910.1 CR599529.1 CR602003.1 CR603005.1 CR604062.1 CR604992.1 CR605816.1 CR609382.1 CR609856.1 CR610819.1 CR613355.1 CR613461.1 CR613589.1 CR613793.1 CR614838.1 CR615069.1 CR615438.1 CR616083.1 CR616842.1 CR617519.1 CR623226.1 CR623351.1 CR623690.1 CR623721.1 CR625404.1 CR625985.1 CR626541.1 24/58 DOTS entries (see all 58
): DT.100059670 DT.95104877 DT.100684438 DT.95104864 DT.87017337 DT.91902613 DT.120904247 DT.91653807 DT.100684442 DT.120904262 DT.92458766 DT.101985363 DT.120904344 DT.100059669 DT.95104803 DT.120904210 DT.40230571 DT.92458767 DT.100684418 DT.100684424 DT.100684431 DT.40133598 DT.95104822 DT.120904201 24/958 AceView cDNA sequences (see all 958
):BU165608 AA370549 BU159203 T30050 BE764165 CR597715 BF732285 CD673641 D17113 CB152060 BQ647329 BM927022 BM711276 BF724545 BM992600 BQ932197 BE501665 CR609382 CR623721 F04131 T30042 BI816783 BU731737 CA442909
highest scoring ESTs for WBP2:AA054051 AA296323 AF087866 AI815598 AK057881 AL537268 AL539025 AL540582 AL541556 AL555717 Unigene Cluster for WBP2: WW domain binding protein 2 Hs.514489 [show with all ESTs]Unigene Representative Sequence: NM_012478
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for WBP2 (see all 11
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | - |   | - |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for WBP2
1 Ensembl transcript including schematic representation: ENST00000254806
|
Expression for WBP2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| WBP2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for WBP2
1 / 2 / 3 3 probe-sets matching WBP2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AAGTGAGGAG
SOURCE GeneReport for Unigene cluster: Hs.514489
Expression variation in blood from EXPOLDB for WBP2 UniProtKB/Swiss-Prot: WBP2_HUMAN, Q969T9Tissue specificity: Ubiquitous |
Orthologs for WBP2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for WBP2 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for WBP2
ENSEMBL Gene Tree for WBP2 | Paralogs for WBP2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for WBP2 gene
- WBP2NL2
|
SNPs/Variants for WBP2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for WBP2 (up to first 250kb)
|
Disorders & Mutations for WBP2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606962
|
Medical News for WBP2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for WBP2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for WBP2 gene (see all 13
):- Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)3, 4 Tao W.A.... Aebersold R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands. (PubMed id 9202023)3, 4 Chen H.I.... Sudol M. (1997)
- Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PubMed id 9169421)3, 4 Pirozzi G.... Fowlkes D.M. (1997)
- The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. (PubMed id 7644498)2, 3 Chen H.I. and Sudol M. (1995)
- WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. (PubMed id 16772533)1, 3 Dhananjayan S.C....Nawaz Z. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8. (PubMed id 14531730)3 Nitsch R....Zannini M. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for WBP2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing WBP2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing WBP2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WBP2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for WBP2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for WBP2:

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Incremental update: 13 Oct 2009
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