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WBP2 Gene

protein-coding   GIFtS: 54
GCID: GC17M073841

WW Domain Binding Protein 2

  Search for WBP2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WW Domain Binding Protein 21 2
WBP-22 3
WW Domain-Binding Protein 22

External Ids:    HGNC: 127381   Entrez Gene: 235582   Ensembl: ENSG000001324717   OMIM: 6069625   UniProtKB: Q969T93   

Export aliases for WBP2 gene to outside databases

Previous GC identifers: GC17M073818 GC17M076868 GC17M074305 GC17M074438 GC17M071353 GC17M069267


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WBP2 Gene:
The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions
including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein
interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which
binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not
been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for WBP2 Gene:
WBP2 (WW domain binding protein 2) is a protein-coding gene. An important paralog of this gene is WBP2NL.

Gene Wiki entry for WBP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the WBP2 gene promoter:
         E2F-3a   E2F-4   GR   E2F-5   p53   GR-beta   E2F-2   E2F   E2F-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWBP2 promoter sequence
   Search Chromatin IP Primers for WBP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25

WBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WBP2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M073841:  view genomic region     (about GC identifiers)

Start:
73,841,780 bp from pter      End:
73,852,588 bp from pter
Size:
10,809 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WBP2_HUMAN, Q969T9 (See protein sequence)
Recommended Name: WW domain-binding protein 2  
Size: 261 amino acids; 28087 Da
Subunit: Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with NEDD4 (By similarity)
Sequence caution: Sequence=AAD10951.1; Type=Erroneous initiation;
Secondary accessions: O95638

Explore the universe of human proteins at neXtProt for WBP2: NX_Q969T9

Explore proteomics data for WBP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WBP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036610.2  
    ENSEMBL proteins: 
     ENSP00000467583   ENSP00000467579   ENSP00000466999   ENSP00000466450   ENSP00000464782  
     ENSP00000465052   ENSP00000415251   ENSP00000468793   ENSP00000464820   ENSP00000464768  
     ENSP00000254806   ENSP00000341570  

    WBP2 Human Recombinant Protein Products:

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    Novus Biologicals WBP2 Proteins
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    Cloud-Clone Corp. Proteins for WBP2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR018826 WW-domain-binding
     IPR004182 GRAM

    Graphical View of Domain Structure for InterPro Entry Q969T9

    ProtoNet protein and cluster: Q969T9

    UniProtKB/Swiss-Prot: WBP2_HUMAN, Q969T9
    Domain: The WW-binding 1 motif mediates interaction with NEDD4 (By similarity)
    Similarity: Contains 1 GRAM domain


    Find genes that share domains with WBP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with WBP2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for WBP2:
     Decreased POU5F1-GFP protein e  Increased number of cells in m 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target WBP2:
    hsa-mir-423-5p (MIRT038101), hsa-mir-744-5p (MIRT037483), hsa-mir-324-5p (MIRT043192), hsa-mir-335-5p (MIRT018302), hsa-mir-19b-3p (MIRT031220), hsa-mir-361-5p (MIRT044096), hsa-mir-455-3p (MIRT037894)

    Block miRNA regulation of human, mouse, rat WBP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WBP2 (see all 26):
    hsa-miR-582-3p hsa-miR-1288 hsa-miR-629 hsa-miR-320e hsa-miR-7-1* hsa-miR-889 hsa-miR-205* hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidWBP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WBP2

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    GenScript: all cDNA clones in your preferred vector: WBP2 (NM_012478)
    Sino Biological Human cDNA Clone for WBP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WBP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WBP2
    Addgene plasmids for WBP2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    peroxisome2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with WBP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WBP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    2Tyrosine Kinases / Adaptors
    Tyrosine Kinases / Adaptors


    Find genes that share SuperPaths with WBP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for WBP2
        Wnt / Hedgehog / Notch
    Tyrosine Kinases / Adaptors



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WBP2
    Interactions:

        GeneGlobe Interaction Network for WBP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for WBP2 (Q969T91, 2, 3 ENSP000002548064) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WWOXQ9NZC72, 3, ENSP000003861614MINT-72786 I2D: score=3 STRING: ENSP00000386161
    SEPT3Q9UH032, 3, ENSP000003797044MINT-65566 I2D: score=4 STRING: ENSP00000379704
    CLEC4GQ6UXB43, ENSP000003275994I2D: score=2 STRING: ENSP00000327599
    ITCHQ96J023, ENSP000003639984I2D: score=2 STRING: ENSP00000363998
    WWP2O003083, ENSP000003482834I2D: score=1 STRING: ENSP00000348283
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with WBP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WBP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WBP2 gene: 
    NM_012478.3  

    Unigene Cluster for WBP2:

    WW domain binding protein 2
    Hs.514489  [show with all ESTs]
    Unigene Representative Sequence: NM_012478
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000585462 ENST00000591399 ENST00000587642 ENST00000591831 ENST00000590221
    ENST00000586257 ENST00000588373 ENST00000433525 ENST00000589236 ENST00000416574(uc010wsn.1)
    ENST00000589642 ENST00000587374 ENST00000593002 ENST00000589241 ENST00000590450
    ENST00000589834 ENST00000592802 ENST00000254806(uc002jps.3 uc010wsl.2 uc010wsm.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat WBP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WBP2 (see all 26):
    hsa-miR-582-3p hsa-miR-1288 hsa-miR-629 hsa-miR-320e hsa-miR-7-1* hsa-miR-889 hsa-miR-205* hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidWBP2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for WBP2
    Predesigned siRNA for gene silencing in human, mouse, rat WBP2
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WBP2 (NM_012478)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WBP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WBP2
    Addgene plasmids for WBP2 
    Primer
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    OriGene qPCR primer pairs and template standards for WBP2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WBP2
      QuantiTect SYBR Green Assays in human, mouse, rat WBP2
      QuantiFast Probe-based Assays in human, mouse, rat WBP2

    Additional mRNA sequence: 

    AF087866.1 AK057881.1 AK293214.1 AK294082.1 AK294155.1 AK300875.1 AL049981.1 BC007452.1 
    BC010616.1 

    Selected DOTS entries (see all 56):

    DT.100059670  DT.95104877  DT.100684438  DT.95104864  DT.87017337  DT.91902613  DT.120904247  DT.91653807 
    DT.100684442  DT.120904262  DT.92458766  DT.101985363  DT.120904344  DT.100059669  DT.95104803  DT.120904210 
    DT.40230571  DT.100684418  DT.100684424  DT.100684431  DT.40133598  DT.95104822  DT.120904201  DT.120904227 

    Selected AceView cDNA sequences (see all 958):

    BQ712484 BE764165 CR597715 CB129363 BQ069539 CB138318 BQ057395 CF242999 
    BU501637 BM473836 BQ683604 AL520082 CB144432 BM564475 CD518835 CR597910 
    T33273 CD676074 BQ888726 BM711276 CB126669 BU541892 CR609856 CB152060 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WBP2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                          -                 -           -     -                 -     -     -                                                         
    SP2:                          -                 -           -     -           -     -     -     -     -     -     -     -                                 
    SP3:                          -           -     -           -     -                                                                                       
    SP4:                          -                 -           -                                                                                             
    SP5:                                            -           -     -                 -     -     -                                                         


    ECgene alternative splicing isoforms for WBP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTGAGGAG
    WBP2 Expression
    About this image

    WBP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WBP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514489

    UniProtKB/Swiss-Prot: WBP2_HUMAN, Q969T9
    Tissue specificity: Ubiquitous

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    QuantiFast Probe-based Assays in human, mouse, rat WBP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WBP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wbp21 , 5 WW domain binding protein 21, 5 91.06(n)1
    96.93(a)1
      11 (80.91 cM)5
    223781  NM_016852.21  NP_058548.11 
     1160785735 
    chicken
    (Gallus gallus)
    Aves WBP21 WW domain binding protein 2 74.93(n)
    80.31(a)
      417368  NM_001278018.1  NP_001264947.1 
    lizard
    (Anolis carolinensis)
    Reptilia WBP26
    WW domain binding protein 2
    81(a)
    1 ↔ 1
    2(113471926-113493453)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687432 hypothetical protein MGC68743 75.04(n)    BC060358.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC053232.12   -- 76.08(n)   325287  BC053232.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Wbp26
    Wbp2 ortholog
    29(a)
    1 → many
    3L(12843260-12846269)
    worm
    (Caenorhabditis elegans)
    Secernentea C18B2.46
    D2013.66
    Protein D2013.6 (D2013.6) mRNA, complete cds
    32(a)
    31(a)
    many ↔ many
    many ↔ many
    X(3604348-3605741) WBGene00015955
    II(9329757-9331543) WBGene00008404


    ENSEMBL Gene Tree for WBP2 (if available)
    TreeFam Gene Tree for WBP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WBP2 gene
    WBP2NL2  
    2 SIMAP similar genes for WBP2 using alignment to 11 protein entries:     WBP2_HUMAN (see all proteins):
    DKFZp564D012    WBP2NL

    Find genes that share paralogs with WBP2           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for WBP2
    PGOHUM00000242181 PGOHUM00000239401 PGOHUM00000234902


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WBP2 (see all 330)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1995184151,2
    --73842860(+) GGCGGC/TGGCTG 2 P syn10--------
    rs2016666161,2
    --73842869(+) TGGCTC/TTAAAG 1 -- spa10--------
    rs23059141,2
    C,F,A,H--73842892(-) TGCAAG/ATCTCT 1 -- int123Minor allele frequency- A:0.30EA NS NA WA CSA EU 4044
    rs1391643831,2
    --73842925(+) CGGTCA/TTCCCC 1 -- int10--------
    rs1115856351,2
    C--73842987(+) CTCTCA/C/TCCGTG 1 -- spd11CSA 1
    rs2005341751,2
    --73842996(+) TGGGCA/GTGTAG 2 T M mis10--------
    rs1390175981,2
    C,F--73842998(+) GGCATG/ATAGAC 2 /Y syn11Minor allele frequency- A:0.00NA 4550
    rs1998978771,2
    C--73843003(+) GTAGAC/TGTTGT 2 I V mis10--------
    rs351719471,2
    C,F--73843040(+) CTGGCG/AGCTGC 2 /A syn15Minor allele frequency- A:0.02NA WA EA EU 6179
    rs1124027111,2
    C,F--73843182(+) CACCAA/GTGAGA 1 -- int13Minor allele frequency- G:0.14CSA WA 122

    HapMap Linkage Disequilibrium report for WBP2 (73841780 - 73852588 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for WBP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908804CNV Loss21882294
    nsv908820CNV Loss21882294
    dgv3268n71CNV Loss21882294
    dgv3267n71CNV Loss21882294
    nsv470606CNV Loss18288195
    nsv510728CNV Loss20534489
    dgv3264n71CNV Loss21882294
    nsv908821CNV Loss21882294
    nsv833545CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606962    OMIM disorders: --


    Find genes that share disorders with WBP2           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: WBP2 (1 document)

    Export disorders for WBP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WBP2 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with WBP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PubMed id 9169421)1, 2 Pirozzi G.... Fowlkes D.M. (J. Biol. Chem. 1997)
    3. Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands. (PubMed id 9202023)1, 2 Chen H.I.... Sudol M. (J. Biol. Chem. 1997)
    4. The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. (PubMed id 7644498)1, 3 Chen H.I. and Sudol M. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    5. WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. (PubMed id 16772533)1, 9 Dhananjayan S.C....Nawaz Z. (Mol. Endocrinol. 2006)
    6. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    7. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    8. Molecular mechanism of WW-domain binding protein-2 coactivation function in estrogen receptor signaling. (PubMed id 23233354)1 Buffa L....Nawaz Z. (IUBMB Life 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23558 HGNC: 12738 AceView: WBP2 Ensembl:ENSG00000132471 euGenes: HUgn23558
    ECgene: WBP2 H-InvDB: WBP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for WBP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WBP2 gene:
    Search GeneIP for patents involving WBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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