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Aliases for WBP2 Gene

Aliases for WBP2 Gene

  • WW Domain Binding Protein 2 2 3 5
  • WBP-2 3 4
  • WW Domain-Binding Protein 2 3
  • GRAMD6 3

External Ids for WBP2 Gene

Previous GeneCards Identifiers for WBP2 Gene

  • GC17M073818
  • GC17M076868
  • GC17M074305
  • GC17M074438
  • GC17M071353
  • GC17M073841
  • GC17M069267

Summaries for WBP2 Gene

Entrez Gene Summary for WBP2 Gene

  • The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein that is a transcriptional coactivator of estrogen receptor alpha and progesterone receptor. Defects in this gene have been associated with hearing impairment. [provided by RefSeq, Jan 2017]

GeneCards Summary for WBP2 Gene

WBP2 (WW Domain Binding Protein 2) is a Protein Coding gene. Among its related pathways are Wnt / Hedgehog / Notch and Tyrosine Kinases / Adaptors. GO annotations related to this gene include RNA polymerase II core promoter sequence-specific DNA binding and RNA polymerase II transcription coactivator activity. An important paralog of this gene is WBP2NL.

Gene Wiki entry for WBP2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WBP2 Gene

Genomics for WBP2 Gene

Regulatory Elements for WBP2 Gene

Enhancers for WBP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G075782 1.4 ENCODE dbSUPER 11.4 +71.5 71487 5.3 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 UNC13D TRIM65 NUP85 UNK NT5C WBP2 ENSG00000266980 FBF1 ENSG00000267546 TMEM94
GH17G075821 0.9 ENCODE dbSUPER 12.3 +34.3 34335 1.8 NFIC PKNOX1 NFIB POLR2A AGO1 REST ZIC2 RBFOX2 UNC13D UNK WBP2 LOC100507191 GC17P075840
GH17G075857 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.8 -2.3 -2273 2.8 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 ELK1 GATA2 FOS REST TRIM65 FBF1 TRIM47 H3F3B GRB2 UNC13D WBP2 UBALD2 SAP30BP ACOX1
GH17G075288 2.1 FANTOM5 Ensembl ENCODE dbSUPER 4.6 +562.8 562849 11.0 CREB3L1 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 GRB2 NUP85 SUMO2 CDK3 H3F3B TMEM94 ENSG00000267342 LLGL2 UNK TEN1
GH17G076032 0.9 ENCODE 10.6 -176.2 -176167 1.2 ZFP64 ARID4B DMAP1 RAD21 ZNF48 RARA MIXL1 THAP11 KLF11 ZHX2 FBF1 EXOC7 WBP2 UNC13D TEN1 EVPL GC17P076053 PIR59290
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WBP2 on UCSC Golden Path with GeneCards custom track

Promoters for WBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098463 907 2001 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21

Genomic Location for WBP2 Gene

Chromosome:
17
Start:
75,845,699 bp from pter
End:
75,856,507 bp from pter
Size:
10,809 bases
Orientation:
Minus strand

Genomic View for WBP2 Gene

Genes around WBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WBP2 Gene

Proteins for WBP2 Gene

  • Protein details for WBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969T9-WBP2_HUMAN
    Recommended name:
    WW domain-binding protein 2
    Protein Accession:
    Q969T9
    Secondary Accessions:
    • O95638

    Protein attributes for WBP2 Gene

    Size:
    261 amino acids
    Molecular mass:
    28087 Da
    Quaternary structure:
    • Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with NEDD4 (By similarity).
    SequenceCaution:
    • Sequence=AAD10951.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WBP2 Gene

Post-translational modifications for WBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WBP2 Gene

Domains & Families for WBP2 Gene

Gene Families for WBP2 Gene

Protein Domains for WBP2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q969T9

UniProtKB/Swiss-Prot:

WBP2_HUMAN :
  • The WW-binding 1 motif mediates interaction with NEDD4.
Domain:
  • The WW-binding 1 motif mediates interaction with NEDD4.
genes like me logo Genes that share domains with WBP2: view

Function for WBP2 Gene

Gene Ontology (GO) - Molecular Function for WBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IMP 23233354
GO:0001105 RNA polymerase II transcription coactivator activity IMP,IEA 23233354
GO:0005515 protein binding IPI 20972459
GO:0031490 chromatin DNA binding IMP 23233354
genes like me logo Genes that share ontologies with WBP2: view
genes like me logo Genes that share phenotypes with WBP2: view

Animal Models for WBP2 Gene

MGI Knock Outs for WBP2:
  • Wbp2 tm2a(EUCOMM)Wtsi

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WBP2
  • Applied Biological Materials Clones for WBP2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WBP2 Gene

Localization for WBP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WBP2 gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for WBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 23233354
genes like me logo Genes that share ontologies with WBP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WBP2 Gene

Pathways & Interactions for WBP2 Gene

genes like me logo Genes that share pathways with WBP2: view

Pathways by source for WBP2 Gene

2 Cell Signaling Technology pathways for WBP2 Gene

Gene Ontology (GO) - Biological Process for WBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0045184 establishment of protein localization IMP 23233354
GO:0045815 positive regulation of gene expression, epigenetic IEA,IMP 23233354
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP,IEA 23233354
GO:0071391 cellular response to estrogen stimulus IEA,IMP 23233354
genes like me logo Genes that share ontologies with WBP2: view

No data available for SIGNOR curated interactions for WBP2 Gene

Drugs & Compounds for WBP2 Gene

No Compound Related Data Available

Transcripts for WBP2 Gene

Unigene Clusters for WBP2 Gene

WW domain binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WBP2
  • Applied Biological Materials Clones for WBP2

Alternative Splicing Database (ASD) splice patterns (SP) for WBP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - -
SP6:
SP7: - -
SP8: - - - - - -
SP9:
SP10:
SP11: -

Relevant External Links for WBP2 Gene

GeneLoc Exon Structure for
WBP2
ECgene alternative splicing isoforms for
WBP2

Expression for WBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WBP2 Gene

Protein differential expression in normal tissues from HIPED for WBP2 Gene

This gene is overexpressed in Breast (8.9), Skin (7.9), and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WBP2 Gene



Protein tissue co-expression partners for WBP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WBP2 Gene:

WBP2

SOURCE GeneReport for Unigene cluster for WBP2 Gene:

Hs.514489

mRNA Expression by UniProt/SwissProt for WBP2 Gene:

Q969T9-WBP2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for WBP2 Gene

  • Nervous system(5)
  • Skin(4)
  • Eye(3.6)
  • Lung(3.6)
  • Blood(3.4)
  • Intestine(3.4)
  • Kidney(3.3)
  • Liver(2.5)
  • Muscle(2.4)
  • Heart(2.3)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with WBP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WBP2 Gene

Orthologs for WBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for WBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WBP2 34 35
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia WBP2 34 35
  • 92.46 (n)
cow
(Bos Taurus)
Mammalia WBP2 34 35
  • 91.06 (n)
mouse
(Mus musculus)
Mammalia Wbp2 34 16 35
  • 91.06 (n)
rat
(Rattus norvegicus)
Mammalia Wbp2 34
  • 88.63 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 86 (a)
OneToMany
-- 35
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves WBP2 34 35
  • 74.93 (n)
lizard
(Anolis carolinensis)
Reptilia WBP2 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wbp2 34
  • 67.44 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68743 34
zebrafish
(Danio rerio)
Actinopterygii wbp2 35
  • 64 (a)
OneToOne
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Wbp2 35
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C18B2.4 35
  • 32 (a)
ManyToMany
D2013.6 35
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2824 35
  • 40 (a)
OneToMany
Species where no ortholog for WBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WBP2 Gene

ENSEMBL:
Gene Tree for WBP2 (if available)
TreeFam:
Gene Tree for WBP2 (if available)

Paralogs for WBP2 Gene

Paralogs for WBP2 Gene

Pseudogenes.org Pseudogenes for WBP2 Gene

genes like me logo Genes that share paralogs with WBP2: view

Variants for WBP2 Gene

Sequence variations from dbSNP and Humsavar for WBP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000062560 -- 75,854,005(+) GTGCC(A/G)CTGCA intron-variant
rs1000356414 -- 75,849,348(+) GTTGC(A/G)CTAAG intron-variant
rs1000797249 -- 75,847,969(+) GCCTG(C/T)CTTGG intron-variant
rs1001200365 -- 75,855,101(+) ACCCC(C/G)CCCCC intron-variant
rs1001631501 -- 75,848,575(+) CTTGA(A/G)ATGCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for WBP2 Gene

Variant ID Type Subtype PubMed ID
nsv470606 CNV loss 18288195
nsv510728 CNV deletion 20534489
nsv833545 CNV gain 17160897

Variation tolerance for WBP2 Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WBP2 Gene

Human Gene Mutation Database (HGMD)
WBP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WBP2 Gene

Disorders for WBP2 Gene

Relevant External Links for WBP2

Human Genome Epidemiology (HuGE) Navigator
WBP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WBP2

No disorders were found for WBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WBP2 Gene

Publications for WBP2 Gene

  1. Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing. (PMID: 26881968) Buniello A. … Steel K.P. (EMBO Mol Med 2016) 2 3 64
  2. Molecular mechanism of WW-domain binding protein-2 coactivation function in estrogen receptor signaling. (PMID: 23233354) Buffa L. … Nawaz Z. (IUBMB Life 2013) 2 3 64
  3. WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. (PMID: 16772533) Dhananjayan S.C. … Nawaz Z. (Mol. Endocrinol. 2006) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PMID: 9169421) Pirozzi G. … Fowlkes D.M. (J. Biol. Chem. 1997) 3 4 64

Products for WBP2 Gene

  • Addgene plasmids for WBP2

Sources for WBP2 Gene

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