WBP2 Gene
protein-coding GIFtS: 54
GCID: GC17M073841
|
|
WW domain binding protein 2
| |
Aliases
for WBP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WW Domain Binding Protein 21 2 | | WBP-21 2 3 | | WW Domain-Binding Protein 22 |
Export aliases for WBP2 gene to outside databasesPrevious GC identifers: GC17M073818 GC17M076868 GC17M074305 GC17M074438 GC17M071353 GC17M069267 |
Summaries
for WBP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WBP2:
The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functionsincluding structural, regulatory, and signaling proteins. The domain is involved in mediating protein-proteininteractions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds tothe WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined.(provided by RefSeq, Jul 2008)
Gene Wiki entry for WBP2
|
Genomic Views
for WBP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WBP2 gene promoter:
E2F-3a E2F-4 GR E2F-5 p53 GR-beta E2F-2 E2F E2F-1 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for WBP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WBP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25WBP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M073841: view genomic region
(about GC identifiers)
Start:
|
73,841,780 bp from pter |
End:
|
73,852,588 bp from pter |
Size:
|
10,809 bases |
Orientation:
|
minus strand |
|
Proteins
for WBP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WBP2_HUMAN, Q969T9 (See
protein sequence)Recommended Name: WW domain-binding protein 2 Size: 261 amino acids; 28087 Da
Subunit: Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with NEDD4 (By similarity)
Sequence caution: Sequence=AAD10951.1; Type=Erroneous initiation;
Secondary accessions: O95638Explore the universe of human proteins at neXtProt for WBP2: NX_Q969T9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969T9
WBP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036610.2
ENSEMBL proteins: ENSP00000467583 ENSP00000467579 ENSP00000466999 ENSP00000466450 ENSP00000464782 ENSP00000465052 ENSP00000415251 ENSP00000468793 ENSP00000464820 ENSP00000464768 ENSP00000254806 ENSP00000341570
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
WBP2 for ontologies About GeneDecksing
WBP2 Antibody Products:
Assay Products for WBP2: |
Protein
Domains /
Families
for WBP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WBP2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q969T9ProtoNet protein and cluster: Q969T9 UniProtKB/Swiss-Prot: WBP2_HUMAN, Q969T9Domain: The WW-binding 1 motif mediates interaction with NEDD4 (By similarity)Similarity: Contains 1 GRAM domain |
Function
for WBP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WBP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WBP2 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
WBP2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for WBP2:
|
Pathways & Interactions
for WBP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Tyrosine Kinases / Adaptors | | | 2 | Wnt / Hedgehog / Notch | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Cell Signaling Technology (CST) Pathways for WBP2
WBP2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WBP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/18 Interacting proteins for WBP2 (Q969T91, 2, 3 ENSP000002548064) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
WBP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for WBP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WBP2
Search CenterWatch for drugs/clinical trials and news about WBP2
|
Transcripts
for WBP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WBP2 gene: NM_012478.3 Unigene Cluster for WBP2: WW domain binding protein 2 Hs.514489 [show with all ESTs]Unigene Representative Sequence: NM_01247818/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000585462 ENST00000591399 ENST00000587642 ENST00000591831 ENST00000590221
ENST00000586257 ENST00000588373 ENST00000433525 ENST00000589236 ENST00000416574(uc010wsn.1)
ENST00000589642 ENST00000587374 ENST00000593002 ENST00000589241 ENST00000590450
ENST00000589834 ENST00000592802 ENST00000254806(uc002jps.3 uc010wsl.2 uc010wsm.2)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WBP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: AF087866.1 AK057881.1 AK293214.1 AK294082.1 AK294155.1 AK300875.1 AL049981.1 BC007452.1 BC010616.1 24/57 DOTS entries (see all 57): DT.100059670 DT.95104877 DT.100684438 DT.95104864 DT.87017337 DT.91902613 DT.120904247 DT.91653807 DT.100684442 DT.120904262 DT.92458766 DT.101985363 DT.120904344 DT.92458767 DT.100059669 DT.40230571 DT.95104803 DT.120904210 DT.100684418 DT.100684424 DT.100684431 DT.40133598 DT.95104822 DT.120904201 24/958 AceView cDNA sequences (see all 958): CD676074 AI815598 BQ718987 BQ574907 AI358849 BM923812 AA976134 AI620455 CA392701 CB155796 BM474566 BM916854 AW262785 AL049981 BQ935474 BM873703 CD674015 CR617519 BU159203 BE764165 T30398 BQ277733 BE501665 BE764269
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for WBP2 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | - | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | - | | | | - | | - | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for WBP2
|
Expression
for WBP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WBP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGTGAGGAG
About this image
See WBP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WBP2
SOURCE GeneReport for Unigene cluster: Hs.514489
UniProtKB/Swiss-Prot: WBP2_HUMAN, Q969T9Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for WBP2
Primer
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP2 |
Orthologs
for WBP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for WBP2 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
WBP21 |
WW domain binding protein 2 |
77.52(n)
83.14(a) |
|
417368 XM_415626.3 XP_415626.2 |
lizard
(Anolis carolinensis) |
Reptilia |
WBP26 |
-- |
82(a) |
1 ↔ 1 |
2(113471926-113493453) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC687432 |
hypothetical protein MGC68743 |
75.04(n) |
|
BC060358.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC053232.12 |
-- |
76.08(n) |
|
325287 BC053232.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG110091 |
CG11009 |
49.18(n)
41.8(a) |
|
39460 NM_140350.3 NP_648607.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
C18B2.41 |
Protein C18B2.4 |
46.89(n)
36.51(a) |
|
180652 NM_076219.6 NP_508620.1 |
ENSEMBL Gene Tree for WBP2 (if available)
TreeFam Gene Tree for WBP2 (if available) |
Paralogs
for WBP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WBP2 gene
- WBP2NL2
2 SIMAP similar genes for WBP2 using alignment to 11 protein entries: WBP2_HUMAN (see all proteins):DKFZp564D012 WBP2NL
WBP2 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for WBP2
PGOHUM00000242181 PGOHUM00000239401 PGOHUM00000234902
|
Genomic Variants
for WBP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WBP2 (73841780 - 73852588 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WBP2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WBP2 |
|
Disorders
/ Diseases
for WBP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WBP2 for disorders About GeneDecksing
OMIM gene information: 606962
OMIM disorders: --
1  disease for WBP2: About MalaCardsthyroiditis
Human Genome Epidemiology (HuGE) Navigator: WBP2 (1 document)
Export disorders for WBP2 gene to outside databases
|
Publications
for WBP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WBP2 gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with WBP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands. (PubMed id 9202023)1, 2 Chen H.I.... Sudol M. (1997)
- Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PubMed id 9169421)1, 2 Pirozzi G.... Fowlkes D.M. (1997)
- The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. (PubMed id 7644498)1, 3 Chen H.I. and Sudol M. (1995)
- WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. (PubMed id 16772533)1, 9 Dhananjayan S.C....Nawaz Z. (2006)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors. (PubMed id 21981024)1 McDonald C.B....Farooq A. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ. (PubMed id 20972459)1 Chan S.W....Hong W. (2011)
|
External Searches for WBP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WBP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WBP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WBP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WBP2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WBP2 gene:
Search GeneIP for patents involving WBP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WBP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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|
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