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WBP2 Gene

protein-coding   GIFtS: 56

GC17M071353
WW domain binding protein 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
MGC18269 2
WBP-2 1, 2, 3
Descriptions
WW domain binding protein 2 2
External Ids
HGNC: 127381
Entrez Gene: 235582
UniProtKB: Q969T93
Ensembl: ENSG000001324717
Search outside databases for aliases for WBP2 gene

Previous GC identifers: GC17M073818 GC17M076868 GC17M074305 GC17M074438

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for WBP2:
The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of
diverse functions including structural, regulatory, and signaling proteins. The domain is involved
in mediating protein-protein interactions through the binding of polyproline ligands. This gene
encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein
by its PY motifs. The function of this protein has not been determined. [provided by RefSeq]

Gene Wiki entry for WBP2
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WBP2 gene  

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25

WBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M071353:     (about GC identifiers)

Start:
71,353,375 bp from pter
End:
71,363,096 bp from pter
Size:
9,722 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000017.9  NT_010641.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WBP2_HUMAN, Q969T9 (See protein sequence)
Recommended Name: WW domain-binding protein 2  
Size: 261 amino acids; 28087 Da
Subunit: Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with NEDD4 (By similarity)
Secondary accessions: O95638

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_036610.2  

    ENSEMBL proteins: 
    ENSP00000254806 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (WBP2)
    Human Recombinant Proteins from Abnova (WBP2)
                  OriGene Purified Recombinant Human Protein: WBP2 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575 cellular_component ND--
    About this table

    Antibodies for WBP2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Antibodies from Abcam (WBP2), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (WBP2)
    Novus Biologicals Antibodies for WBP2

    Assays for WBP2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR018826 WW-domain-binding
     IPR004182 GRAM


       GeneDecks  WBP2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q969T9

    ProtoNet protein and cluster: Q969T9

    UniProtKB/Swiss-Prot: WBP2_HUMAN, Q969T9
    Domain: The WW-binding 1 motif mediates interaction with NEDD4 (By similarity)
    Similarity: Contains 1 GRAM domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WBP2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012478

                  Applied Biosystems Silencer® siRNAs for WBP2

                  Sigma-Aldrich siRNA for WBP2  
                         Sigma-Aldrich shRNA for WBP2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for WBP2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_012478
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_012478
                                     untagged cDNA clones in CMV expression vector (see all 3): AL049981 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_012478

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding NAS7644498
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  WBP2 


    5/6 Interacting proteins for WBP2 (ENSP000002548063 Q969T92) via UniProtKB, MINT, and/or STRING (see all 6 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WWOXQ9NZC72MINT-72786
    PAX8ENSP000002633343STRING (score=.965)
    WBP1ENSP000002336153STRING (score=.95)
    ABCC11ENSP000003490173STRING (score=.928)
    NEDD4ENSP000003455303STRING (score=.823)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150 biological_process ND--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for WBP2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WBP2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012478

                  Sigma-Aldrich siRNA for WBP2  
                         Sigma-Aldrich shRNA for WBP2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_012478  

    REFSEQ mRNAs for WBP2 gene: 

    NM_012478.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_012478  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_012478
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_012478
                                     untagged cDNA clones in CMV expression vector (see all 3): AL049981 

    Additional cDNA sequence: 

    AF087866.1 AK057881.1 AK293214.1 AK294082.1 AK294155.1 AK300875.1 AL049981.1 BC007452.1 
    BC010616.1 CR590489.1 CR596623.1 CR597688.1 CR597715.1 CR597910.1 CR599529.1 CR602003.1 
    CR603005.1 CR604062.1 CR604992.1 CR605816.1 CR609382.1 CR609856.1 CR610819.1 CR613355.1 
    CR613461.1 CR613589.1 CR613793.1 CR614838.1 CR615069.1 CR615438.1 CR616083.1 CR616842.1 
    CR617519.1 CR623226.1 CR623351.1 CR623690.1 CR623721.1 CR625404.1 CR625985.1 CR626541.1 

    24/58 DOTS entries (see all 58 ):

    DT.100059670  DT.95104877  DT.100684438  DT.95104864  DT.87017337  DT.91902613  DT.120904247  DT.91653807 
    DT.100684442  DT.120904262  DT.92458766  DT.101985363  DT.120904344  DT.100059669  DT.95104803  DT.120904210 
    DT.40230571  DT.92458767  DT.100684418  DT.100684424  DT.100684431  DT.40133598  DT.95104822  DT.120904201 

    24/958 AceView cDNA sequences (see all 958 ):

    BU165608 AA370549 BU159203 T30050 BE764165 CR597715 BF732285 CD673641 
    D17113 CB152060 BQ647329 BM927022 BM711276 BF724545 BM992600 BQ932197 
    BE501665 CR609382 CR623721 F04131 T30042 BI816783 BU731737 CA442909 

    highest scoring ESTs for WBP2:

    AA054051 AA296323 AF087866 AI815598 AK057881 AL537268 AL539025 AL540582 AL541556 AL555717 

    Unigene Cluster for WBP2:

    WW domain binding protein 2
    Hs.514489  [show with all ESTs]
    Unigene Representative Sequence: NM_012478


    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for WBP2 (see all 11 )

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                          -                 -           -     -                 -     -     -                                                         
    SP2:                          -                 -           -     -           -     -     -     -     -     -     -     -                                 
    SP3:                          -           -     -           -     -                                                                                       
    SP4:                          -                 -           -                                                                                             
    SP5:                                            -           -     -                 -     -     -                                                         

    About this scheme

    ECgene alternative splicing isoforms for WBP2

    1 Ensembl transcript including schematic representation:
    ENST00000254806  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    WBP2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for WBP2

    1 / 2 / 3

    3 probe-sets matching WBP2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    33438_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AL049981 0.80 0.88 0.84 1

    209117_at2, 3 U133-A 1 1.00 1.00 -- -- U79458 0.60 1.00 0.82 1

    209117_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AAGTGAGGAG

    SOURCE GeneReport for Unigene cluster: Hs.514489

    Expression variation in blood from EXPOLDB for WBP2

    UniProtKB/Swiss-Prot: WBP2_HUMAN, Q969T9
    Tissue specificity: Ubiquitous

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for WBP2 gene from 5/10 species (see all 10 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    WBP21   -- WW domain binding protein 2 92.46(n)
    97.7(a)
    608477  XM_844270.1  XP_849363.1 
    cow
    (Bos taurus)
    WBP21   -- WW domain binding protein 2 91.06(n)
    96.17(a)
    507060  XM_583611.3  XP_583611.2 
    rat
    (Rattus norvegicus)
    Wbp21   -- WW domain binding protein 2 90.29(n)
    96.17(a)
    192645  NM_138975.1  NP_620431.1 
    mouse
    (Mus musculus)
    Wbp21, 5 115
    WW domain binding protein 21, 5 91.06(n)1
    96.93(a)1
    223781  NM_016852.21  NP_058548.11 
     AK0048245  AK0430375  (see all 17)
    chicken
    (Gallus gallus)
    WBP21   -- WW domain binding protein 2 77.52(n)
    83.14(a)
    417368  XM_415626.2  XP_415626.2 
    About this table        Species with no ortholog for WBP2

    ENSEMBL Gene Tree for WBP2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for WBP2 gene
    WBP2NL2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/71 NCBI SNPs in WBP2 are shown (see all 71 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 37)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs14634851,2
    A,C,F,H71363386(+) GGGGAC/GTCCGG 1 -- ng317Minor allele frequency- G:0.26MN EU EA WA 958
    rs9363941,2
    A,F71363603(+) TCTCAC/ACACTC 1 -- ng312Minor allele frequency- A:0.30MN EA 356
    rs351719471,2
    F71354635(+) CTGGCG/AGCTGC 1 A/A syn11Minor allele frequency- A:0.03NA 78
    rs9363931,2
    A,C,F,H71359208(-) AGGCTT/CGTTGC 1 -- int113Minor allele frequency- C:0.21EU EA WA NA 2446
    --
    rs9363911,2
    A,C,F,H71359394(-) CGTCTC/TCATAC 1 -- int17Minor allele frequency- T:0.34EU EA NA 1836
    rs23059141,2
    A,C,F71354487(-) TGCAAG/ATCTCT 1 -- int11Minor allele frequency- A:0.34EA 1492
    rs22907711,2
    C,F,H71356343(-) CCCCTT/CTCAGG 1 -- int1 trp35Minor allele frequency- C:0.23EA EU WA 1898
    --
    rs39882111,2
    A,C71357700(-) AACACC/TGCCAC 1 -- int10--------
    --
    rs9363961,2
    A,C71358424(-) cactgC/Gattct 1 -- int10--------
    --
    rs20044521,2
    A71358111(-) accccA/Gtctct 1 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for WBP2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 606962

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/13 PubMed articles for WBP2 gene (see all 13 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 23558 HGNC: 12738 AceView: WBP2 Ensembl:ENSG00000132471 euGenes: HUgn23558
    ECgene: WBP2 H-InvDB: WBP2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for WBP2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for WBP2 Browse small molecules at Sigma-Aldrich
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     shRNA in GFP-retroviral vector
     Search Tocris compounds for WBP2




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for WBP2

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