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Aliases for WBP2 Gene

Aliases for WBP2 Gene

  • WW Domain Binding Protein 2 2 3 5
  • WBP-2 3 4
  • GRAMD6 3

External Ids for WBP2 Gene

Previous GeneCards Identifiers for WBP2 Gene

  • GC17M073818
  • GC17M076868
  • GC17M074305
  • GC17M074438
  • GC17M071353
  • GC17M073841
  • GC17M069267

Summaries for WBP2 Gene

Entrez Gene Summary for WBP2 Gene

  • The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for WBP2 Gene

WBP2 (WW Domain Binding Protein 2) is a Protein Coding gene. Among its related pathways are Wnt / Hedgehog / Notch and Tyrosine Kinases / Adaptors. GO annotations related to this gene include RNA polymerase II core promoter sequence-specific DNA binding and RNA polymerase II transcription coactivator activity. An important paralog of this gene is WBP2NL.

Gene Wiki entry for WBP2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WBP2 Gene

Genomics for WBP2 Gene

Regulatory Elements for WBP2 Gene

Enhancers for WBP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WBP2 on UCSC Golden Path with GeneCards custom track

Promoters for WBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WBP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for WBP2 Gene

75,845,699 bp from pter
75,856,507 bp from pter
10,809 bases
Minus strand

Genomic View for WBP2 Gene

Genes around WBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WBP2 Gene

Proteins for WBP2 Gene

  • Protein details for WBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WW domain-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • O95638

    Protein attributes for WBP2 Gene

    261 amino acids
    Molecular mass:
    28087 Da
    Quaternary structure:
    • Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with NEDD4 (By similarity).
    • Sequence=AAD10951.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WBP2 Gene

Proteomics data for WBP2 Gene at MOPED

Post-translational modifications for WBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for WBP2 (WBP2)
  • Abcam antibodies for WBP2

No data available for DME Specific Peptides for WBP2 Gene

Domains & Families for WBP2 Gene

Gene Families for WBP2 Gene

Protein Domains for WBP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • The WW-binding 1 motif mediates interaction with NEDD4.
  • The WW-binding 1 motif mediates interaction with NEDD4.
  • Contains 1 GRAM domain.
genes like me logo Genes that share domains with WBP2: view

Function for WBP2 Gene

Gene Ontology (GO) - Molecular Function for WBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IMP 23233354
GO:0031490 chromatin DNA binding IMP 23233354
genes like me logo Genes that share ontologies with WBP2: view
genes like me logo Genes that share phenotypes with WBP2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WBP2 Gene

Localization for WBP2 Gene

Subcellular locations from

Jensen Localization Image for WBP2 Gene COMPARTMENTS Subcellular localization image for WBP2 gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WBP2 Gene

Pathways & Interactions for WBP2 Gene

genes like me logo Genes that share pathways with WBP2: view

Pathways by source for WBP2 Gene

2 Cell Signaling Technology pathways for WBP2 Gene

Gene Ontology (GO) - Biological Process for WBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071442 positive regulation of histone H3-K14 acetylation IMP 23233354
genes like me logo Genes that share ontologies with WBP2: view

No data available for SIGNOR curated interactions for WBP2 Gene

Drugs & Compounds for WBP2 Gene

No Compound Related Data Available

Transcripts for WBP2 Gene

Unigene Clusters for WBP2 Gene

WW domain binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WBP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - -
SP7: - -
SP8: - - - - - -
SP11: -

Relevant External Links for WBP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WBP2 Gene

mRNA expression in normal human tissues for WBP2 Gene

Protein differential expression in normal tissues from HIPED for WBP2 Gene

This gene is overexpressed in Breast (8.9), Skin (7.9), and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WBP2 Gene

SOURCE GeneReport for Unigene cluster for WBP2 Gene Hs.514489

mRNA Expression by UniProt/SwissProt for WBP2 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with WBP2: view

Protein tissue co-expression partners for WBP2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WBP2 Gene

Orthologs for WBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for WBP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WBP2 35
  • 91.06 (n)
  • 96.17 (a)
WBP2 36
  • 66 (a)
(Canis familiaris)
Mammalia WBP2 35
  • 92.46 (n)
  • 97.7 (a)
WBP2 36
  • 96 (a)
(Mus musculus)
Mammalia Wbp2 35
  • 91.06 (n)
  • 96.93 (a)
Wbp2 16
Wbp2 36
  • 97 (a)
(Pan troglodytes)
Mammalia WBP2 35
  • 99.8 (n)
  • 100 (a)
WBP2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Wbp2 35
  • 88.63 (n)
  • 94.25 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
-- 36
  • 81 (a)
(Gallus gallus)
Aves WBP2 35
  • 74.93 (n)
  • 80.31 (a)
WBP2 36
  • 77 (a)
(Anolis carolinensis)
Reptilia WBP2 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wbp2 35
  • 67.44 (n)
  • 66.02 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68743 35
(Danio rerio)
Actinopterygii -- 35
wbp2 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta Wbp2 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea C18B2.4 36
  • 32 (a)
D2013.6 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2824 36
  • 40 (a)
Species with no ortholog for WBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WBP2 Gene

Gene Tree for WBP2 (if available)
Gene Tree for WBP2 (if available)

Paralogs for WBP2 Gene

Paralogs for WBP2 Gene Pseudogenes for WBP2 Gene

genes like me logo Genes that share paralogs with WBP2: view

Variants for WBP2 Gene

Sequence variations from dbSNP and Humsavar for WBP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs936391 -- 75,851,718(-) CGTCT(C/T)CATAC intron-variant
rs936392 -- 75,851,717(-) GTCTC(C/T)ATACT intron-variant
rs936393 -- 75,851,532(-) AGGCT(C/T)GTTGC intron-variant
rs936394 -- 75,855,927(+) TCTCA(A/C)CACTC upstream-variant-2KB
rs936395 -- 75,856,035(+) CCCTC(C/G/T)CAGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WBP2 Gene

Variant ID Type Subtype PubMed ID
dgv3264n71 CNV Loss 21882294
nsv908804 CNV Loss 21882294
dgv3267n71 CNV Loss 21882294
dgv3268n71 CNV Loss 21882294
nsv833545 CNV Gain 17160897
nsv470606 CNV Loss 18288195
nsv908820 CNV Loss 21882294
nsv510728 CNV Loss 20534489
nsv908821 CNV Loss 21882294

Variation tolerance for WBP2 Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WBP2 Gene

Disorders for WBP2 Gene

Relevant External Links for WBP2

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WBP2 Gene

Publications for WBP2 Gene

  1. Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing. (PMID: 26881968) Buniello A. … Steel K.P. (EMBO Mol Med 2016) 2 3 67
  2. Molecular mechanism of WW-domain binding protein-2 coactivation function in estrogen receptor signaling. (PMID: 23233354) Buffa L. … Nawaz Z. (IUBMB Life 2013) 2 3
  3. WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. (PMID: 16772533) Dhananjayan S.C. … Nawaz Z. (Mol. Endocrinol. 2006) 3 23
  4. The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. (PMID: 7644498) Chen H.I. … Sudol M. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for WBP2 Gene

Sources for WBP2 Gene