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Aliases for WBP2 Gene

Aliases for WBP2 Gene

  • WW Domain Binding Protein 2 2 3 5
  • WBP-2 3 4
  • WW Domain-Binding Protein 2 3
  • DFNB107 3
  • GRAMD6 3

External Ids for WBP2 Gene

Previous GeneCards Identifiers for WBP2 Gene

  • GC17M073818
  • GC17M076868
  • GC17M074305
  • GC17M074438
  • GC17M071353
  • GC17M073841
  • GC17M069267

Summaries for WBP2 Gene

Entrez Gene Summary for WBP2 Gene

  • The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein that is a transcriptional coactivator of estrogen receptor alpha and progesterone receptor. Defects in this gene have been associated with hearing impairment. [provided by RefSeq, Jan 2017]

GeneCards Summary for WBP2 Gene

WBP2 (WW Domain Binding Protein 2) is a Protein Coding gene. Diseases associated with WBP2 include Deafness, Autosomal Recessive 107. Among its related pathways are Tyrosine Kinases / Adaptors and Wnt / Hedgehog / Notch. GO annotations related to this gene include RNA polymerase II core promoter sequence-specific DNA binding and RNA polymerase II transcription coactivator activity. An important paralog of this gene is WBP2NL.

Gene Wiki entry for WBP2 Gene

Additional gene information for WBP2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WBP2 Gene

Genomics for WBP2 Gene

Regulatory Elements for WBP2 Gene

Enhancers for WBP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H075782 1.4 ENCODE dbSUPER 11.4 +71.5 71487 5.3 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC SRSF2 UNK TRIM65 NUP85 NT5C ENSG00000267342 UNC13D GGA3 ENSG00000264829 HMGN2P43
GH17H075821 0.8 ENCODE dbSUPER 12.3 +34.3 34335 1.8 NFIC PKNOX1 POLR2A NFIB ZIC2 UNC13D UNK WBP2 ENSG00000266980 GC17P075840
GH17H075288 2.1 FANTOM5 Ensembl ENCODE dbSUPER 4.6 +562.8 562849 11 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 ZNF610 GRB2 NUP85 ENSG00000266980 UNK RECQL5 CDK3 SLC25A19 GGA3 H3F3B TMEM94
GH17H076032 0.9 ENCODE 10.6 -176.2 -176167 1.2 ZFP64 ARID4B DMAP1 RARA MIXL1 THAP11 KLF11 ZHX2 MIER2 PPARG FBF1 EXOC7 WBP2 UNC13D TEN1 EVPL GC17P076053 PIR59290
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WBP2 on UCSC Golden Path with GeneCards custom track

Promoters for WBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for WBP2 Gene

Genomic Locations for WBP2 Gene
10,809 bases
Minus strand

Genomic View for WBP2 Gene

Genes around WBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WBP2 Gene

Proteins for WBP2 Gene

  • Protein details for WBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WW domain-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • O95638

    Protein attributes for WBP2 Gene

    261 amino acids
    Molecular mass:
    28087 Da
    Quaternary structure:
    • Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with NEDD4 (By similarity).
    • Sequence=AAD10951.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WBP2 Gene

Post-translational modifications for WBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WBP2 Gene

Domains & Families for WBP2 Gene

Gene Families for WBP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WBP2 Gene


Graphical View of Domain Structure for InterPro Entry



  • The WW-binding 1 motif mediates interaction with NEDD4.
  • The WW-binding 1 motif mediates interaction with NEDD4.
genes like me logo Genes that share domains with WBP2: view

Function for WBP2 Gene

Phenotypes From GWAS Catalog for WBP2 Gene

Gene Ontology (GO) - Molecular Function for WBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IMP 23233354
GO:0001105 RNA polymerase II transcription coactivator activity IMP,IEA 23233354
GO:0005515 protein binding IPI 20972459
GO:0031490 chromatin DNA binding IMP 23233354
genes like me logo Genes that share ontologies with WBP2: view
genes like me logo Genes that share phenotypes with WBP2: view

Animal Models for WBP2 Gene

MGI Knock Outs for WBP2:
  • Wbp2 tm2a(EUCOMM)Wtsi

Animal Model Products

Clone Products

  • Addgene plasmids for WBP2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WBP2 Gene

Localization for WBP2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WBP2 gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 23233354
genes like me logo Genes that share ontologies with WBP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WBP2 Gene

Pathways & Interactions for WBP2 Gene

genes like me logo Genes that share pathways with WBP2: view

Pathways by source for WBP2 Gene

2 Cell Signaling Technology pathways for WBP2 Gene

Gene Ontology (GO) - Biological Process for WBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045184 establishment of protein localization IMP 23233354
GO:0045815 positive regulation of gene expression, epigenetic IEA,IMP 23233354
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA,IMP 23233354
GO:0071391 cellular response to estrogen stimulus IMP,IEA 23233354
GO:0071442 positive regulation of histone H3-K14 acetylation IMP 23233354
genes like me logo Genes that share ontologies with WBP2: view

No data available for SIGNOR curated interactions for WBP2 Gene

Drugs & Compounds for WBP2 Gene

No Compound Related Data Available

Transcripts for WBP2 Gene

Unigene Clusters for WBP2 Gene

WW domain binding protein 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for WBP2

Alternative Splicing Database (ASD) splice patterns (SP) for WBP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - -
SP7: - -
SP8: - - - - - -
SP11: -

Relevant External Links for WBP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WBP2 Gene

Protein differential expression in normal tissues from HIPED for WBP2 Gene

This gene is overexpressed in Breast (8.9), Skin (7.9), and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WBP2 Gene

Protein tissue co-expression partners for WBP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WBP2 Gene:


SOURCE GeneReport for Unigene cluster for WBP2 Gene:


mRNA Expression by UniProt/SwissProt for WBP2 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for WBP2 Gene

  • Nervous system(5)
  • Skin(4)
  • Eye(3.6)
  • Lung(3.6)
  • Blood(3.4)
  • Intestine(3.4)
  • Kidney(3.3)
  • Liver(2.5)
  • Muscle(2.4)
  • Heart(2.3)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with WBP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WBP2 Gene

Orthologs for WBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for WBP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WBP2 33 34
  • 99.8 (n)
(Canis familiaris)
Mammalia WBP2 33 34
  • 92.46 (n)
(Bos Taurus)
Mammalia WBP2 33 34
  • 91.06 (n)
(Mus musculus)
Mammalia Wbp2 16 34 33
  • 91.06 (n)
(Rattus norvegicus)
Mammalia Wbp2 33
  • 88.63 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 86 (a)
-- 34
  • 81 (a)
(Gallus gallus)
Aves WBP2 33 34
  • 74.93 (n)
(Anolis carolinensis)
Reptilia WBP2 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wbp2 33
  • 67.44 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68743 33
(Danio rerio)
Actinopterygii wbp2 34
  • 64 (a)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta Wbp2 34
  • 29 (a)
(Caenorhabditis elegans)
Secernentea C18B2.4 34
  • 32 (a)
D2013.6 34
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2824 34
  • 40 (a)
Species where no ortholog for WBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WBP2 Gene

Gene Tree for WBP2 (if available)
Gene Tree for WBP2 (if available)

Paralogs for WBP2 Gene

Paralogs for WBP2 Gene Pseudogenes for WBP2 Gene

genes like me logo Genes that share paralogs with WBP2: view

Variants for WBP2 Gene

Sequence variations from dbSNP and Humsavar for WBP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000062560 -- 75,854,005(+) GTGCC(A/G)CTGCA intron-variant
rs1000356414 -- 75,849,348(+) GTTGC(A/G)CTAAG intron-variant
rs1000797249 -- 75,847,969(+) GCCTG(C/T)CTTGG intron-variant
rs1001200365 -- 75,855,101(+) ACCCC(C/G)CCCCC intron-variant
rs1001631501 -- 75,848,575(+) CTTGA(A/G)ATGCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for WBP2 Gene

Variant ID Type Subtype PubMed ID
nsv833545 CNV gain 17160897
nsv510728 CNV deletion 20534489
nsv470606 CNV loss 18288195

Variation tolerance for WBP2 Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WBP2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WBP2 Gene

Disorders for WBP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WBP2 Gene - From: OMIM and ClinVar

Disorder Aliases PubMed IDs
deafness, autosomal recessive 107
- elite association - COSMIC cancer census association via MalaCards
Search WBP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WBP2

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with WBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WBP2 Gene

Publications for WBP2 Gene

  1. Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing. (PMID: 26881968) Buniello A … Steel KP (EMBO molecular medicine 2016) 2 3 60
  2. Molecular mechanism of WW-domain binding protein-2 coactivation function in estrogen receptor signaling. (PMID: 23233354) Buffa L … Nawaz Z (IUBMB life 2013) 2 3 60
  3. WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. (PMID: 16772533) Dhananjayan SC … Nawaz Z (Molecular endocrinology (Baltimore, Md.) 2006) 3 22 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PMID: 9169421) Pirozzi G … Fowlkes DM (The Journal of biological chemistry 1997) 3 4 60

Products for WBP2 Gene

  • Addgene plasmids for WBP2

Sources for WBP2 Gene

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