WBP1L Gene
protein-coding GIFtS: 40
GCID: GC10P104504
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|
WW domain binding protein 1-like(Previous name: chromosome 10 open reading frame 26 )
(Previous symbol: C10orf26)
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Aliases
for WBP1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WW Domain Binding Protein 1-Like1 2 | | OPA1L2 3 | | C10orf261 2 3 5 | | FLJ201541 | | OPAL11 2 5 | | Chromosome 10 Open Reading Frame 261 | | Outcome Predictor In Acute Leukemia 12 3 | | |
Export aliases for WBP1L gene to outside databases |
Summaries
for WBP1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for WBP1L (C10orf26)
|
Genomic Views
for WBP1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for WBP1L
Other transcription factors
Search SABiosciences Chromatin IP Primers for WBP1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WBP1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24.32 Ensembl cytogenetic band: 10q24.32 HGNC cytogenetic band: 10q24.33WBP1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P104504: view genomic region
(about GC identifiers)
Start:
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104,503,727 bp from pter |
End:
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104,576,021 bp from pter |
Size:
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72,295 bases |
Orientation:
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plus strand |
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Proteins
for WBP1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WBP1L_HUMAN, Q9NX94 (See
protein sequence)Recommended Name: WW domain binding protein 1-like Size: 342 amino acids; 37828 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=BAA91122.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KPF4 B7Z6S7 D3DR90 Q1EG70 Q2HIY7 Q5F2G6Alternative splicing: 2 isoforms: Q9NX94-1 Q9NX94-2 Explore the universe of human proteins at neXtProt for WBP1L: NX_Q9NX94
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NX94
WBP1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001077382.1 NP_060257.4
ENSEMBL proteins: ENSP00000358905 ENSP00000414721
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
WBP1L for ontologies About GeneDecksing
WBP1L Antibody Products:
Assay Products for WBP1L: |
Protein
Domains /
Families
for WBP1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WBP1L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NX94ProtoNet protein and cluster: Q9NX94 |
Function
for WBP1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WBP1L (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WBP1L (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP1L |
1 GenomeRNAi human phenotype for WBP1L:
|
Pathways & Interactions
for WBP1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WBP1L
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for WBP1L (ENSP000004147214) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for WBP1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WBP1L
Search CenterWatch for drugs/clinical trials and news about WBP1L
|
Transcripts
for WBP1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WBP1L gene (2 alternative transcripts): NM_001083913.1 NM_017787.4 Unigene Clusters for WBP1L: WW domain binding protein 1-like Hs.500897 [show with all ESTs], Hs.693257 Unigene Representative Sequences: NM_017787, AY6561742 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369889(uc001kwe.4) ENST00000448841(uc001kwf.4 uc009xxg.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WBP1L (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WBP1L (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for WBP1L | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WBP1L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WBP1L |
Additional cDNA sequence: AY656174.1 13 DOTS entries: DT.452085 DT.100719087 DT.100746187 DT.95174728 DT.97819468 DT.100028914 DT.121299713 DT.97844370 DT.100665971 DT.75129198 DT.97823601 DT.97825263 DT.91957907 24/261 AceView cDNA sequences (see all 261): AA983333 AW519142 BM838772 AA187617 F24405 NM_017787 BM714825 AI200433 H25348 AI369298 AA573401 BX100578 CD721919 CR591598 AA954841 BM510572 AA758121 AI215566 CA426767 AW264562 BC063659 AA430020 BM708561 BF195955
GeneLoc Exon Structure
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Expression
for WBP1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See WBP1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WBP1L
SOURCE GeneReport for Unigene clusters: Hs.500897 Hs.693257
SABiosciences Custom PCR Arrays for WBP1L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WBP1L
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat WBP1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WBP1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WBP1L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP1L |
Orthologs
for WBP1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for WBP1L gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Wbp1l5
D19Wsu162e1 |
DNA segment, Chr 19, Wayne State University 162, expressed1, 5 |
87.79(n)1
88.43(a)1 |
|
19 (38.97 cM)5
2261781 NM_146099.31 NP_666211.31
465990845 |
chicken
(Gallus gallus) |
Aves |
C6H10orf261 |
chromosome 6 open reading frame, human C10orf26 |
75.59(n)
75.08(a) |
|
423867 XM_421732.3 XP_421732.1 |
lizard
(Anolis carolinensis) |
Reptilia |
C10orf266 |
-- |
64(a) |
1 ↔ 1 |
3(40205487-40222885) |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc23g112 |
wufc23g11 |
76.7(n) |
|
324292 BI473458.1 |
ENSEMBL Gene Tree for WBP1L (if available)
TreeFam Gene Tree for WBP1L (if available) |
Paralogs
for WBP1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WBP1L gene
- WBP12
1 SIMAP similar gene for WBP1L using alignment to 1 protein entry: WBP1L_HUMAN:WBP1
WBP1L for paralogs About GeneDecksing
5/12 Pseudogenes.org Pseudogenes for WBP1L (see all 12)
PGOHUM00000242547 PGOHUM00000246949 PGOHUM00000234461 PGOHUM00000243866 PGOHUM00000244569
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Genomic Variants
for WBP1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WBP1L (104503727 - 104576021 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WBP1L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WBP1L |
|
Disorders
/ Diseases
for WBP1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WBP1L for disorders About GeneDecksing
OMIM gene information: 611129
OMIM disorders: --
6  diseases for WBP1L: About MalaCardsacute leukemia leukemia intrahepatic cholangiocarcinoma alzheimer's disease
cholangiocarcinoma neuroblastoma
Export disorders for WBP1L gene to outside databases
|
Publications
for WBP1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WBP1L gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with WBP1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Unexpected diversity in Shisa-like proteins suggests t he importance of their roles as transmembrane adaptors. (PubMed id 22120523)1 Pei J. and Grishin N.V. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for WBP1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WBP1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WBP1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WBP1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WBP1L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WBP1L gene:
Search GeneIP for patents involving WBP1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WBP1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | |
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 | | | WBP1L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP1L |
|  |  |  | | | | Search ThermoFisher Antibodies for WBP1L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WBP1L |
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