Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WBP1L Gene

Aliases for WBP1L Gene

  • WW Domain Binding Protein 1-Like 2 3 5
  • Outcome Predictor In Acute Leukemia 1 2 3 4
  • C10orf26 3 4
  • OPA1L 3 4
  • Chromosome 10 Open Reading Frame 26 2
  • OPAL1 3

External Ids for WBP1L Gene

Previous HGNC Symbols for WBP1L Gene

  • C10orf26

Previous GeneCards Identifiers for WBP1L Gene

  • GC10P104504

Summaries for WBP1L Gene

GeneCards Summary for WBP1L Gene

WBP1L (WW Domain Binding Protein 1-Like) is a Protein Coding gene. Diseases associated with WBP1L include Acute Leukemia. An important paralog of this gene is WBP1.

Gene Wiki entry for WBP1L Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WBP1L Gene

Genomics for WBP1L Gene

Regulatory Elements for WBP1L Gene

Enhancers for WBP1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WBP1L on UCSC Golden Path with GeneCards custom track

Genomic Location for WBP1L Gene

Chromosome:
10
Start:
102,739,283 bp from pter
End:
102,816,267 bp from pter
Size:
76,985 bases
Orientation:
Plus strand

Genomic View for WBP1L Gene

Genes around WBP1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WBP1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WBP1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WBP1L Gene

Proteins for WBP1L Gene

  • Protein details for WBP1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX94-WBP1L_HUMAN
    Recommended name:
    WW domain binding protein 1-like
    Protein Accession:
    Q9NX94
    Secondary Accessions:
    • B3KPF4
    • B7Z6S7
    • D3DR90
    • Q1EG70
    • Q2HIY7
    • Q5F2G6

    Protein attributes for WBP1L Gene

    Size:
    342 amino acids
    Molecular mass:
    37828 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91122.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for WBP1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WBP1L Gene

Proteomics data for WBP1L Gene at MOPED

Post-translational modifications for WBP1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WBP1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WBP1L Gene

Domains & Families for WBP1L Gene

Protein Domains for WBP1L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WBP1L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for WBP1L Gene

Function for WBP1L Gene

Phenotypes for WBP1L Gene

genes like me logo Genes that share phenotypes with WBP1L: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WBP1L Gene

Localization for WBP1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for WBP1L Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WBP1L Gene COMPARTMENTS Subcellular localization image for WBP1L gene
Compartment Confidence
cytoskeleton 2
extracellular 2
nucleus 2
plasma membrane 2
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for WBP1L Gene

Pathways & Interactions for WBP1L Gene

SuperPathways for WBP1L Gene

No Data Available

Interacting Proteins for WBP1L Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000414721%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000221566%0d%0a
Selected Interacting proteins: ENSP00000414721 Q9NX94-WBP1L_HUMAN for WBP1L Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for WBP1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WBP1L Gene

Drugs & Compounds for WBP1L Gene

No Compound Related Data Available

Transcripts for WBP1L Gene

Alternative Splicing Database (ASD) splice patterns (SP) for WBP1L Gene

No ASD Table

Relevant External Links for WBP1L Gene

GeneLoc Exon Structure for
WBP1L
ECgene alternative splicing isoforms for
WBP1L

Expression for WBP1L Gene

mRNA expression in normal human tissues for WBP1L Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WBP1L Gene



SOURCE GeneReport for Unigene cluster for WBP1L Gene Hs.500897

genes like me logo Genes that share expression patterns with WBP1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for WBP1L Gene

Orthologs for WBP1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for WBP1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C26H10orf26 35
  • 91.1 (n)
  • 90.91 (a)
WBP1L 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WBP1L 35
  • 91.45 (n)
  • 92.59 (a)
WBP1L 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wbp1l 35
  • 87.88 (n)
  • 88.35 (a)
Wbp1l 16
Wbp1l 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wbp1l 35
  • 89.3 (n)
  • 90.62 (a)
oppossum
(Monodelphis domestica)
Mammalia WBP1L 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WBP1L 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves C6H10ORF26 35
  • 74.41 (n)
  • 73.24 (a)
WBP1L 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WBP1L 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wbp1l 35
  • 65.81 (n)
  • 66.45 (a)
zebrafish
(Danio rerio)
Actinopterygii wbp1la 35
  • 58.98 (n)
  • 57.47 (a)
wufc23g11 35
wbp1la 36
  • 46 (a)
OneToMany
wbp1lb 36
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2554 36
  • 33 (a)
OneToMany
Species with no ortholog for WBP1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WBP1L Gene

ENSEMBL:
Gene Tree for WBP1L (if available)
TreeFam:
Gene Tree for WBP1L (if available)

Paralogs for WBP1L Gene

Paralogs for WBP1L Gene

(1) SIMAP similar genes for WBP1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WBP1L: view

Variants for WBP1L Gene

Sequence variations from dbSNP and Humsavar for WBP1L Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs284860 - 102,813,206(-) AGAGG(A/G)CTGAC reference, missense
rs284859 - 102,813,260(-) GCATG(A/C/T)GGGCG reference, missense
rs1475642 -- 102,786,426(+) TATAC(A/G)TAAAC intron-variant
rs1475643 -- 102,786,710(+) CAGAC(C/T)AGATT intron-variant
rs1475646 -- 102,762,807(-) GGGAC(A/C)AACAG intron-variant

Variation tolerance for WBP1L Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.72; 73.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for WBP1L Gene

Disorders for WBP1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for WBP1L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acute leukemia
  • stem cell leukaemia
- elite association - COSMIC cancer census association via MalaCards
Search WBP1L in MalaCards View complete list of genes associated with diseases

Relevant External Links for WBP1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WBP1L
genes like me logo Genes that share disorders with WBP1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WBP1L Gene

Publications for WBP1L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3
  5. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 3

Products for WBP1L Gene

Sources for WBP1L Gene

Content