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WBP1L Gene

protein-coding   GIFtS: 39
GCID: GC10P104504

WW Domain Binding Protein 1-Like

(Previous name: chromosome 10 open reading frame 26)
(Previous symbol: C10orf26)
  See WBP1L-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WW Domain Binding Protein 1-Like1 2
C10orf261 2 3 5
Outcome Predictor In Acute Leukemia 11 2 3
OPA1L2 3
OPAL12 5
Chromosome 10 Open Reading Frame 261

External Ids:    HGNC: 235101   Entrez Gene: 548382   Ensembl: ENSG000001662727   OMIM: 6111295   UniProtKB: Q9NX943   

Export aliases for WBP1L gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for WBP1L Gene:
WBP1L (WW domain binding protein 1-like) is a protein-coding gene. Diseases associated with WBP1L include acute leukemia. An important paralog of this gene is WBP1.

Gene Wiki entry for WBP1L (C10orf26) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Search for regulatory transcription factor binding sites for WBP1L
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for WBP1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WBP1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.32   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24.33

WBP1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WBP1L gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P104504:  view genomic region     (about GC identifiers)

Start:
104,503,727 bp from pter      End:
104,576,021 bp from pter
Size:
72,295 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WBP1L_HUMAN, Q9NX94 (See protein sequence)
Recommended Name: WW domain binding protein 1-like  
Size: 342 amino acids; 37828 Da
Sequence caution: Sequence=BAA91122.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KPF4 B7Z6S7 D3DR90 Q1EG70 Q2HIY7 Q5F2G6
Alternative splicing: 2 isoforms:  Q9NX94-1   Q9NX94-2   

Explore the universe of human proteins at neXtProt for WBP1L: NX_Q9NX94

Explore proteomics data for WBP1L at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WBP1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001077382.1  NP_060257.4  

    ENSEMBL proteins: 
     ENSP00000358905   ENSP00000414721  

    WBP1L Human Recombinant Protein Products:

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    antibodies-online peptides for WBP1L

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR021684 Uncharacterised_WW-bd

    Graphical View of Domain Structure for InterPro Entry Q9NX94

    ProtoNet protein and cluster: Q9NX94


    Find genes that share domains with WBP1L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for WBP1L:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for WBP1L

    miRNA
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    miRTarBase miRNAs that target WBP1L:
    hsa-mir-615-3p (MIRT040377), hsa-mir-155-5p (MIRT020792), hsa-mir-335-5p (MIRT017867), hsa-mir-760 (MIRT036784), hsa-mir-19b-3p (MIRT031188), hsa-mir-320a (MIRT044576)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WBP1L_HUMAN, Q9NX94: Membrane; Single-pass membrane protein (Potential)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with WBP1L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WBP1L
    Interactions:

        Search GeneGlobe Interaction Network for WBP1L

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for WBP1L (ENSP000004147214) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WBP1L



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WBP1L gene (2 alternative transcripts): 
    NM_001083913.1  NM_017787.4  

    Unigene Cluster for WBP1L:

    WW domain binding protein 1-like
    Hs.500897  [show with all ESTs]
    Unigene Representative Sequence: NM_017787
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369889(uc001kwe.4) ENST00000448841(uc001kwf.4 uc009xxg.1)

    miRNA
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    OriGene qPCR primer pairs and template standards for WBP1L
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      QuantiTect SYBR Green Assays in human, mouse, rat WBP1L
      QuantiFast Probe-based Assays in human, mouse, rat WBP1L

    Additional mRNA sequence: 

    AF070644.1 AK000161.1 AK000374.1 AK056285.1 AK300871.1 AK308843.1 AK316452.1 AY656171.1 
    AY656175.1 BC010506.1 BC063659.1 BC073886.1 BC113857.1 BC114465.1 

    13 DOTS entries:

    DT.452085  DT.100719087  DT.100746187  DT.95174728  DT.97819468  DT.100028914  DT.121299713  DT.97844370 
    DT.100665971  DT.75129198  DT.97823601  DT.97825263  DT.91957907 

    Selected AceView cDNA sequences (see all 261):

    T96208 AW007308 CD721919 BM510572 AA954841 AA430020 BU726404 BX100578 
    CF121236 AA878773 NM_017787 AA573401 CA389094 AW419058 CA426767 BM708488 
    AA187617 AI638808 BU617651 AW519132 AA234055 AI554618 BC063659 BM714825 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WBP1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    WBP1L Expression
    About this image

    WBP1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WBP1L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500897
        Custom PCR Arrays for WBP1L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for WBP1L gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wbp1l1 , 5 DNA segment, Chr 19, Wayne State University 162, expressed5
    WW domain binding protein 1 like1
    87.88(n)1
    88.35(a)1
      19 (38.97 cM)5
    2261781  NM_001177812.11  NP_001171283.11 
     465990845 
    chicken
    (Gallus gallus)
    Aves C6H10ORF261 chromosome 6 open reading frame, human C10orf26 74.41(n)
    73.24(a)
      423867  XM_004942244.1  XP_004942301.1 
    lizard
    (Anolis carolinensis)
    Reptilia WBP1L6
    WW domain binding protein 1-like
    66(a)
    1 ↔ 1
    3(40205487-40224627)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wbp1l1 WW domain binding protein 1-like 65.81(n)
    66.45(a)
      100037888  NM_001097326.1  NP_001090795.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc23g112 wufc23g11 76.7(n)   324292  BI473458.1 


    ENSEMBL Gene Tree for WBP1L (if available)
    TreeFam Gene Tree for WBP1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WBP1L gene
    WBP12  
    1 SIMAP similar gene for WBP1L using alignment to 1 protein entry:     WBP1L_HUMAN:
    WBP1

    Find genes that share paralogs with WBP1L           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for WBP1L (see all 12)
    PGOHUM00000242547 PGOHUM00000246949 PGOHUM00000234461 PGOHUM00000243866 PGOHUM00000244569


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WBP1L (see all 1431)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs79018891,2
    C,H--104501931(+) tttttC/Tttttt 1 -- us2k10--------
    rs79185071,2
    C,H--104501932(+) ttttcT/Cttttt 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs112929661,2
    C--104501932(+) TTTTC-/TTTTTT 1 -- us2k12Minor allele frequency- T:0.25NA CSA 4
    rs1123510031,2
    C,F--104501965(+) GTCACG/CTAGGG 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1461915431,2
    --104501998(+) GGCTCA/GCTGCA 1 -- us2k10--------
    rs79187391,2
    C--104502114(+) gagatG/Tgggtt 1 -- us2k16Minor allele frequency- T:0.00WA NA 12
    rs1879119191,2
    --104502160(+) TGATCC/TGCCCA 1 -- us2k10--------
    rs1439423371,2
    --104502161(+) GATCCA/GCCCAC 1 -- us2k10--------
    rs113906291,2
    C--104502217(+) GCCTT-/T/TT  
            
    TTTTT
    1 -- us2k10--------
    rs1912191011,2
    --104502369(+) CACCAC/TGCTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WBP1L (104503727 - 104576021 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for WBP1L: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WBP1L
    DNA2.0 Custom Variant and Variant Library Synthesis for WBP1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611129    OMIM disorders: --

    1 disease for WBP1L:    
    About MalaCards
    acute leukemia


    Find genes that share disorders with WBP1L           About GenesLikeMe


    Export disorders for WBP1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WBP1L gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with WBP1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    4. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    5. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PubMed id 23974872)1 Ripke S....Sullivan P.F. (Nat. Genet. 2013)
    6. Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. (PubMed id 22120523)1 Pei J. and Grishin N.V. (Cell. Signal. 2012)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54838 HGNC: 23510 AceView: C10orf26 Ensembl:ENSG00000166272 euGenes: HUgn54838
    ECgene: WBP1L H-InvDB: WBP1L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WBP1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WBP1L gene:
    Search GeneIP for patents involving WBP1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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