Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



WBP11 Gene

protein-coding   GIFtS: 51
GCID: GC12M014939

WW Domain Binding Protein 11

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
WW Domain Binding Protein 111 2     Splicing Factor1
Splicing Factor That Interacts With PQBP-1 And PP12 3     Npw38-Binding Protein NpwBP2
NPWBP2 3     Splicing Factor, PQBP1 And PP1 Interacting2
SIPP12 3     WW Domain-Binding Protein 112
WBP-112 3     NpwBP3
SH3 Domain-Binding Protein SNP702 3     SNP703
PQBP1 And PP1 Interacting1     Npw38-Binding Protein3

External Ids:    HGNC: 164611   Entrez Gene: 517292   Ensembl: ENSG000000844637   UniProtKB: Q9Y2W23   

Export aliases for WBP11 gene to outside databases

Previous GC identifers: GC12M014679 GC12M015084 GC12M014839 GC12M014830 GC12M014708


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for WBP11 Gene:
This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate
filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11
protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus
this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of
an mRNA factory in the nucleus. (provided by RefSeq, Jul 2008)

GeneCards Summary for WBP11 Gene:
WBP11 (WW domain binding protein 11) is a protein-coding gene. GO annotations related to this gene include protein phosphatase type 1 regulator activity and single-stranded DNA binding.

UniProtKB/Swiss-Prot: WBP11_HUMAN, Q9Y2W2
Function: Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity

Gene Wiki entry for WBP11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the WBP11 gene promoter:
         COUP-TF1   AML1a   COUP   Olf-1   HNF-4alpha2   NF-E2 p45   POU3F2   HNF-4alpha1   COUP-TF   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWBP11 promoter sequence
   Search Chromatin IP Primers for WBP11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WBP11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12.3

WBP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WBP11 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M014939:  view genomic region     (about GC identifiers)

Start:
14,939,410 bp from pter      End:
14,956,474 bp from pter
Size:
17,065 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: WBP11_HUMAN, Q9Y2W2 (See protein sequence)
Recommended Name: WW domain-binding protein 11  
Size: 641 amino acids; 69998 Da
Subunit: Interacts with PPP1CA, PPP1CB and PPP1CC (By similarity). Interacts via the PGR motif with PQBP1 in the
nucleus. Interacts with the WW domains of WBP4
Secondary accessions: Q96AY8

Explore the universe of human proteins at neXtProt for WBP11: NX_Q9Y2W2

Explore proteomics data for WBP11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WBP11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057396.1  
    ENSEMBL proteins: 
     ENSP00000261167   ENSP00000443420   ENSP00000440988  

    WBP11 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for WBP11
    GenScript Custom Purified and Recombinant Proteins Services for WBP11
    Novus Biologicals WBP11 Protein
    Novus Biologicals WBP11 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WBP11

     
    Search eBioscience for Proteins for WBP11 

    WBP11 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for WBP11
    OriGene Custom Antibody Services for WBP11
    Novus Biologicals WBP11 Antibodies
    Abcam antibodies for WBP11
    Cloud-Clone Corp. Antibodies for WBP11
    ThermoFisher Antibody for WBP11
    LSBio Antibodies in human, mouse, rat for WBP11

    WBP11 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for WBP11
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WBP11
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WBP11
    Cloud-Clone Corp. CLIAs for WBP11
    Search eBioscience for ELISAs for WBP11 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR019007 WW_dom-bd_prot_11

    Graphical View of Domain Structure for InterPro Entry Q9Y2W2

    ProtoNet protein and cluster: Q9Y2W2


    Find genes that share domains with WBP11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WBP11_HUMAN, Q9Y2W2
    Function: Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003697single-stranded DNA binding TAS10593949
    GO:0005515protein binding IPI16713569
    GO:0008599protein phosphatase type 1 regulator activity IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0050699WW domain binding IPI19592703
         
    Find genes that share ontologies with WBP11           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for WBP11:
     Decreased viability  Decreased viability of wild-ty  Increased circadian period len  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WBP11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WBP11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WBP11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WBP11

    miRNA
    Products:
        
    miRTarBase miRNAs that target WBP11:
    hsa-let-7c-5p (MIRT051869), hsa-mir-34a-5p (MIRT025244), hsa-let-7b-5p (MIRT052331), hsa-mir-98-5p (MIRT027410), hsa-mir-877-5p (MIRT037321), hsa-mir-16-5p (MIRT031437)

    Block miRNA regulation of human, mouse, rat WBP11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WBP11 (see all 22):
    hsa-miR-194* hsa-miR-640 hsa-miR-520d-5p hsa-miR-15a hsa-miR-216b hsa-miR-424 hsa-miR-508-5p hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidWBP11 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WBP11
    Predesigned siRNA for gene silencing in human, mouse, rat WBP11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WBP11

    Clone
    Products:
         
    OriGene clones in human, mouse for WBP11 (see all 8)
    OriGene ORF clones in mouse, rat for WBP11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WBP11 (NM_016312)
    Sino Biological Human cDNA Clone for WBP11
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WBP11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WBP11

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for WBP11
    Browse ESI BIO Cell Lines and PureStem Progenitors for WBP11 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    WBP11_HUMAN, Q9Y2W2: Nucleus. Cytoplasm. Note=Predominantly located in the nucleus with granular heterogeneous
    distribution. Excluded from nucleoli in interphase cells, distributed throughout cytoplasm in dividing cells.
    Colocalized with SC35 and U2B in the nucleus. In the cytoplasm, associates with the intermediate filament protein
    vimentin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016607nuclear speck IEA--

    Find genes that share ontologies with WBP11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for WBP11 About    
    See pathways by source

    SuperPathContained pathways About
    1Spliceosome
    Spliceosome


    Find genes that share SuperPaths with WBP11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for WBP11):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WBP11
    Interactions:

        GeneGlobe Interaction Network for WBP11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WBP11 (Q9Y2W21, 2, 3 ENSP000002611674) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCRS1Q96EZ82, 3, ENSP000003496404MINT-68385 I2D: score=5 STRING: ENSP00000349640
    ARF1P840772, 3, ENSP000002721024MINT-64019 I2D: score=4 STRING: ENSP00000272102
    PCBP1Q153651, 3, ENSP000003055564EBI-714455,EBI-946095 I2D: score=1 STRING: ENSP00000305556
    PPP1CAP621362, 3, ENSP000003260314MINT-8336914 I2D: score=1 STRING: ENSP00000326031
    SF3A2Q154282, 3, ENSP000002214944MINT-5205989 I2D: score=1 STRING: ENSP00000221494
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--
    GO:0006396RNA processing ----
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--

    Find genes that share ontologies with WBP11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WBP11



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for WBP11 gene: 
    NM_016312.2  

    Unigene Cluster for WBP11:

    WW domain binding protein 11
    Hs.655138  [show with all ESTs]
    Unigene Representative Sequence: BC023532
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261167(uc001rci.3) ENST00000535638 ENST00000544764 ENST00000535328
    ENST00000543316
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat WBP11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WBP11 (see all 22):
    hsa-miR-194* hsa-miR-640 hsa-miR-520d-5p hsa-miR-15a hsa-miR-216b hsa-miR-424 hsa-miR-508-5p hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidWBP11 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WBP11
    Predesigned siRNA for gene silencing in human, mouse, rat WBP11
    Clone
    Products:
         
    OriGene clones in human, mouse for WBP11 (see all 8)
    OriGene ORF clones in mouse, rat for WBP11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WBP11 (NM_016312)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WBP11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WBP11
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for WBP11
    OriGene qSTAR qPCR primer pairs in human, mouse for WBP11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WBP11
      QuantiTect SYBR Green Assays in human, mouse, rat WBP11
      QuantiFast Probe-based Assays in human, mouse, rat WBP11

    Additional mRNA sequence: 

    AB029309.1 AF118023.1 AK297410.1 AK302244.1 BC001621.1 BC016441.2 BC023532.2 BX647347.1 

    12 DOTS entries:

    DT.115924  DT.95363239  DT.100818165  DT.86855315  DT.100701005  DT.121192941  DT.121192944  DT.121192945 
    DT.121192955  DT.95086905  DT.91871424  DT.95363237 

    Selected AceView cDNA sequences (see all 379):

    N49351 CK724906 BC023532 BM703942 BM479741 H80581 AI377028 AI564297 
    BQ423310 BU196903 BQ644104 BE281472 AA709234 BE018235 BQ424923 F07603 
    BQ652182 BM741910 Z39420 AA911444 C20781 CA488966 F03849 BQ440362 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    WBP11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    WBP11 Expression
    About this image


    WBP11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Testis (Reproductive System)
    WBP11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WBP11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655138

    UniProtKB/Swiss-Prot: WBP11_HUMAN, Q9Y2W2
    Tissue specificity: Ubiquitous. Highly expressed in the heart, pancreas, kidney skeletal muscle, placenta and
    brain (at protein level). Weakly expressed in liver and lung

        Custom PCR Arrays for WBP11
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for WBP11
    OriGene qSTAR qPCR primer pairs in human, mouse for WBP11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WBP11
    QuantiTect SYBR Green Assays in human, mouse, rat WBP11
    QuantiFast Probe-based Assays in human, mouse, rat WBP11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for WBP11 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wbp111 , 5 WW domain binding protein 111, 5 88.14(n)1
    95.08(a)1
      6 (66.72 cM)5
    603211  NM_021714.41  NP_068360.41 
     1368136545 
    chicken
    (Gallus gallus)
    Aves WBP116
    WW domain binding protein 11
    86(a)
    1 ↔ 1
    1(47916130-47924400)
    lizard
    (Anolis carolinensis)
    Reptilia WBP116
    WW domain binding protein 11
    85(a)
    1 ↔ 1
    5(27656127-27673259)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689612 hypothetical protein MGC68961 76.1(n)    BC057737.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.283832 Danio rerio cDNA clone IMAGE6790461, partial cds 73.97(n)    BC056284.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta EG:100G10.13   -- 65(a)   3B3   --


    ENSEMBL Gene Tree for WBP11 (if available)
    TreeFam Gene Tree for WBP11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for WBP11 gene

    Find genes that share paralogs with WBP11           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for WBP11
    PGOHUM00000259278 PGOHUM00000240898 PGOHUM00000260179 PGOHUM00000260973


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for WBP11 (see all 286)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1870782741,2
    --14938980(+) TCTTAC/TTCATT 1 -- ds50010--------
    rs79645991,2
    C,F,A,H--14939009(+) CACACC/AAAACC 1 -- ds500111Minor allele frequency- A:0.21EA NS NA CSA WA 665
    rs1922484721,2
    --14939101(+) CAACTC/TGTATC 1 -- ds50010--------
    rs10519101,2
    H--14939109(-) CTTGAA/GCTGAT 1 -- ds50017Minor allele frequency- G:0.00MN NS EA NA 596
    rs64887121,2
    C,F,A,H--14939332(+) TTAAAA/GACCCA 1 -- ds500114Minor allele frequency- G:0.47NA WA CSA EA 560
    rs1844006241,2
    --14939374(+) AAATAA/GGTATT 1 -- ds50010--------
    rs1167875941,2
    C,F--14939382(+) ATTATG/ATTTAC 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1180963831,2
    F--14939398(+) ATCAGT/CAACAC 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs31798071,2
    C,H--14939411(-) ACCAAG/AATACT 1 -- ds50013Minor allele frequency- A:0.00NS NA 228
    rs1890703461,2
    --14939468(+) CAGTGG/TGAAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for WBP11 (14939410 - 14956474 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WBP11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678294CNV Deletion23128226
    nsv53585CNV Loss16902084
    nsv898817CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WBP11
    DNA2.0 Custom Variant and Variant Library Synthesis for WBP11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for WBP11 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with WBP11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of two nuclear proteins, Npw38 and NpwBP, via the interaction between the WW domain and a novel proline-rich motif containing glycine and arginine. (PubMed id 10593949)1, 2, 3, 9 Komuro A.... Kato S. (J. Biol. Chem. 1999)
    2. SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1. (PubMed id 14640981)1, 2, 9 Llorian M.... Bollen M. (Biochem. J. 2004)
    3. A nuclear SH3 domain-binding protein that colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. (PubMed id 11375989)1, 2, 9 Craggs G.... Kellie S. (J. Biol. Chem. 2001)
    4. Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21). (PubMed id 19592703)1, 2, 9 Huang X.... Shi Y. (J. Biol. Chem. 2009)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PubMed id 23080069)1 Esteves S.L....da Cruz e Silva E.F. (J. Mol. Neurosci. 2013)
    8. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Protein phosphatase 1I+ interacting proteins in the human brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (OMICS 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51729 HGNC: 16461 AceView: WBP11 Ensembl:ENSG00000084463 euGenes: HUgn51729
    ECgene: WBP11 Kegg: 51729 H-InvDB: WBP11

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for WBP11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for WBP11 gene:
    Search GeneIP for patents involving WBP11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for WBP11   OriGene RNAi products in human, mouse, rat for WBP11  
     OriGene qPCR primer pairs and template standards for WBP11   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for WBP11  
     OriGene qSTAR qPCR primer pairs in human, mouse for WBP11   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for WBP11   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for WBP11   OriGene Custom Protein Services for WBP11  

     
     
     Block miRNA regulation of human, mouse, rat WBP11 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing WBP11
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WBP11 Predesigned siRNA for gene silencing in human, mouse, rat WBP11
     QuantiFast Probe-based Assays in human, mouse, rat WBP11 QuantiTect SYBR Green Assays in human, mouse, rat WBP11
     Custom PCR Arrays for WBP11 Search Chromatin IP Primers for WBP11
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WBP11  GeneGlobe Interaction Network for WBP11
     Regulatory tfbs in WBP11 promoter
     GenScript Custom Purified and Recombinant Proteins Services for WBP11 GenScript cDNA clones with any tag delivered in your preferred vector for WBP11
     GenScript Custom Assay Services for WBP11 GenScript Custom overexpressing Cell Line Services for WBP11
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for WBP11
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for WBP11
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     WBP11 antibodies
     WBP11 proteins
     WBP11 lysates
     Antibodies for WBP11
     See all of Abcam's Antibodies, Kits and Proteins for WBP11
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for WBP11
     Antibodies for WBP11
     ELISAs for WBP11
     CLIAs for WBP11



     Browse ESI BIO Cell Lines and PureStem Progenitors for WBP11
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP11
     SwitchGear 3'UTR luciferase reporter plasmids for WBP11
     SwitchGear Promoter luciferase reporter plasmids for WBP11
     ThermoFisher Antibody for WBP11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WBP11
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WBP11
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WBP11
     LSBio Antibodies in human, mouse, rat for WBP11
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for WBP11
      Search eBioscience for proteins for WBP11
      Search eBioscience for elisas for WBP11
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      WBP11 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4