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Aliases for WBP11 Gene

Aliases for WBP11 Gene

  • WW Domain Binding Protein 11 2 3 5
  • Splicing Factor That Interacts With PQBP-1 And PP1 3 4
  • Protein Phosphatase 1, Regulatory Subunit 165 2 3
  • Splicing Factor, PQBP1 And PP1 Interacting 2 3
  • SH3 Domain-Binding Protein SNP70 3 4
  • WBP-11 3 4
  • NPWBP 3 4
  • SIPP1 3 4
  • WW Domain-Binding Protein 11 3
  • Npw38-Binding Protein NpwBP 3
  • Npw38-Binding Protein 4
  • PPP1R165 3
  • SNP70 4

External Ids for WBP11 Gene

Previous GeneCards Identifiers for WBP11 Gene

  • GC12M014679
  • GC12M015084
  • GC12M014839
  • GC12M014830
  • GC12M014939
  • GC12M014708

Summaries for WBP11 Gene

Entrez Gene Summary for WBP11 Gene

  • This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for WBP11 Gene

WBP11 (WW Domain Binding Protein 11) is a Protein Coding gene. Diseases associated with WBP11 include Renpenning Syndrome. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include poly(A) RNA binding and WW domain binding.

UniProtKB/Swiss-Prot for WBP11 Gene

  • Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity.

Gene Wiki entry for WBP11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WBP11 Gene

Genomics for WBP11 Gene

Regulatory Elements for WBP11 Gene

Enhancers for WBP11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around WBP11 on UCSC Golden Path with GeneCards custom track

Promoters for WBP11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WBP11 on UCSC Golden Path with GeneCards custom track

Genomic Location for WBP11 Gene

Chromosome:
12
Start:
14,784,579 bp from pter
End:
14,803,540 bp from pter
Size:
18,962 bases
Orientation:
Minus strand

Genomic View for WBP11 Gene

Genes around WBP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WBP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WBP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WBP11 Gene

Proteins for WBP11 Gene

  • Protein details for WBP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2W2-WBP11_HUMAN
    Recommended name:
    WW domain-binding protein 11
    Protein Accession:
    Q9Y2W2
    Secondary Accessions:
    • Q96AY8

    Protein attributes for WBP11 Gene

    Size:
    641 amino acids
    Molecular mass:
    69998 Da
    Quaternary structure:
    • Interacts with PPP1CA, PPP1CB and PPP1CC (By similarity). Interacts via the PGR motif with PQBP1 in the nucleus. Interacts with the WW domains of WBP4.

neXtProt entry for WBP11 Gene

Post-translational modifications for WBP11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WBP11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WBP11 Gene

Domains & Families for WBP11 Gene

Gene Families for WBP11 Gene

Protein Domains for WBP11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WBP11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WBP11: view

No data available for UniProtKB/Swiss-Prot for WBP11 Gene

Function for WBP11 Gene

Molecular function for WBP11 Gene

UniProtKB/Swiss-Prot Function:
Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity.

Gene Ontology (GO) - Molecular Function for WBP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding TAS 10593949
GO:0005515 protein binding IPI 16713569
GO:0008599 protein phosphatase type 1 regulator activity IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0050699 WW domain binding IPI 19592703
genes like me logo Genes that share ontologies with WBP11: view
genes like me logo Genes that share phenotypes with WBP11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WBP11 Gene

Localization for WBP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WBP11 Gene

Nucleus. Cytoplasm. Note=Predominantly located in the nucleus with granular heterogeneous distribution. Excluded from nucleoli in interphase cells, distributed throughout cytoplasm in dividing cells. Colocalized with SC35 and U2B in the nucleus. In the cytoplasm, associates with the intermediate filament protein vimentin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WBP11 Gene COMPARTMENTS Subcellular localization image for WBP11 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for WBP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS 10593949
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex IBA --
GO:0005737 cytoplasm IEA,IDA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with WBP11: view

Pathways & Interactions for WBP11 Gene

SuperPathways for WBP11 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with WBP11: view

Pathways by source for WBP11 Gene

1 KEGG pathway for WBP11 Gene

Gene Ontology (GO) - Biological Process for WBP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0045292 mRNA cis splicing, via spliceosome IBA --
GO:0050790 regulation of catalytic activity IEA --
GO:1903146 regulation of mitophagy IMP 24912190
genes like me logo Genes that share ontologies with WBP11: view

No data available for SIGNOR curated interactions for WBP11 Gene

Drugs & Compounds for WBP11 Gene

No Compound Related Data Available

Transcripts for WBP11 Gene

Unigene Clusters for WBP11 Gene

WW domain binding protein 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WBP11 Gene

No ASD Table

Relevant External Links for WBP11 Gene

GeneLoc Exon Structure for
WBP11
ECgene alternative splicing isoforms for
WBP11

Expression for WBP11 Gene

mRNA expression in normal human tissues for WBP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WBP11 Gene

This gene is overexpressed in Heart (9.4), Nasal epithelium (9.0), Lung (7.1), CD8 Tcells (6.5), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WBP11 Gene



Protein tissue co-expression partners for WBP11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WBP11 Gene:

WBP11

SOURCE GeneReport for Unigene cluster for WBP11 Gene:

Hs.655138

mRNA Expression by UniProt/SwissProt for WBP11 Gene:

Q9Y2W2-WBP11_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in the heart, pancreas, kidney skeletal muscle, placenta and brain (at protein level). Weakly expressed in liver and lung.
genes like me logo Genes that share expression patterns with WBP11: view

Primer Products

No data available for mRNA differential expression in normal tissues for WBP11 Gene

Orthologs for WBP11 Gene

This gene was present in the common ancestor of animals.

Orthologs for WBP11 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia WBP11 34
  • 94.38 (n)
  • 98.75 (a)
WBP11 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wbp11 34
  • 88.14 (n)
  • 95.08 (a)
Wbp11 16
Wbp11 35
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WBP11 34
  • 99.9 (n)
  • 99.84 (a)
WBP11 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wbp11 34
  • 88.37 (n)
  • 95.75 (a)
cow
(Bos Taurus)
Mammalia -- 35
  • 94 (a)
OneToMany
-- 35
  • 96 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 91 (a)
OneToMany
-- 35
  • 77 (a)
OneToMany
-- 35
  • 90 (a)
OneToMany
-- 35
  • 92 (a)
OneToMany
chicken
(Gallus gallus)
Aves WBP11 35
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WBP11 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1463 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68961 34
zebrafish
(Danio rerio)
Actinopterygii Dr.28383 34
wbp11 35
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EG:100G10.1 36
  • 65 (a)
CG2685 35
  • 39 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11662 34
Species where no ortholog for WBP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WBP11 Gene

ENSEMBL:
Gene Tree for WBP11 (if available)
TreeFam:
Gene Tree for WBP11 (if available)

Paralogs for WBP11 Gene

Pseudogenes.org Pseudogenes for WBP11 Gene

genes like me logo Genes that share paralogs with WBP11: view

No data available for Paralogs for WBP11 Gene

Variants for WBP11 Gene

Structural Variations from Database of Genomic Variants (DGV) for WBP11 Gene

Variant ID Type Subtype PubMed ID
esv2678294 CNV deletion 23128226
esv3548803 CNV deletion 23714750
nsv477236 CNV novel sequence insertion 20440878
nsv53585 CNV deletion 16902084
nsv957913 CNV deletion 24416366
nsv976581 CNV duplication 23825009

Variation tolerance for WBP11 Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WBP11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WBP11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for WBP11 Gene

Disorders for WBP11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WBP11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
renpenning syndrome
  • renpenning syndrome 1
- elite association - COSMIC cancer census association via MalaCards
Search WBP11 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WBP11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WBP11
genes like me logo Genes that share disorders with WBP11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WBP11 Gene

Publications for WBP11 Gene

  1. Association of two nuclear proteins, Npw38 and NpwBP, via the interaction between the WW domain and a novel proline-rich motif containing glycine and arginine. (PMID: 10593949) Komuro A. … Kato S. (J. Biol. Chem. 1999) 2 3 4 22 65
  2. Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21). (PMID: 19592703) Huang X. … Shi Y. (J. Biol. Chem. 2009) 3 4 22 65
  3. SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1. (PMID: 14640981) Llorian M. … Bollen M. (Biochem. J. 2004) 3 4 22 65
  4. A nuclear SH3 domain-binding protein that colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. (PMID: 11375989) Craggs G. … Kellie S. (J. Biol. Chem. 2001) 3 4 22 65
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 65

Products for WBP11 Gene

Sources for WBP11 Gene

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