WBP11 Gene
protein-coding GIFtS: 49
GCID: GC12M014939
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WW domain binding protein 11
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Aliases
for WBP11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WW Domain Binding Protein 111 2 | | Npw38-Binding Protein NpwBP2 | | NPWBP1 2 3 | | Splicing Factor, PQBP1 And PP1 Interacting2 | | SIPP11 2 3 | | WW Domain-Binding Protein 112 | | Splicing Factor That Interacts With PQBP-1 And PP12 3 | | NpwBP3 | | WBP-112 3 | | SNP703 | | SH3 Domain-Binding Protein SNP702 3 | | Npw38-Binding Protein3 |
Export aliases for WBP11 gene to outside databasesPrevious GC identifers: GC12M014679 GC12M015084 GC12M014839 GC12M014830 GC12M014708 |
Summaries
for WBP11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WBP11:
This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containingperinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains twoproline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also calledNpw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: WBP11_HUMAN, Q9Y2W2Function: Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity
Gene Wiki entry for WBP11
|
Genomic Views
for WBP11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WBP11 gene promoter:
COUP-TF1 AML1a COUP Olf-1 HNF-4alpha2 NF-E2 p45 POU3F2 HNF-4alpha1 COUP-TF NF-E2
Other transcription factors
Search SABiosciences Chromatin IP Primers for WBP11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WBP11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p12.3 Ensembl cytogenetic band: 12p12.3 HGNC cytogenetic band: 12p12.3WBP11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M014939: view genomic region
(about GC identifiers)
Start:
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14,939,410 bp from pter |
End:
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14,956,474 bp from pter |
Size:
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17,065 bases |
Orientation:
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minus strand |
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Proteins
for WBP11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WBP11_HUMAN, Q9Y2W2 (See
protein sequence)Recommended Name: WW domain-binding protein 11 Size: 641 amino acids; 69998 Da
Subunit: Interacts with PPP1CA, PPP1CB and PPP1CC (By similarity). Interacts via the PGR motif with PQBP1 in thenucleus. Interacts with the WW domains of WBP4
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly located in the nucleus with granular heterogeneousdistribution. Excluded from nucleoli in interphase cells, distributed throughout cytoplasm in dividing cells.Co-localized with SC35 and U2B in the nucleus. In the cytoplasm, associates with the intermediate filament proteinvimentin
Secondary accessions: Q96AY8Explore the universe of human proteins at neXtProt for WBP11: NX_Q9Y2W2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y2W2
WBP11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057396.1
ENSEMBL proteins: ENSP00000261167 ENSP00000442868 ENSP00000443420 ENSP00000440988
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
WBP11 for ontologies About GeneDecksing
WBP11 Antibody Products:
Assay Products for WBP11: |
Protein
Domains /
Families
for WBP11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WBP11 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y2W2ProtoNet protein and cluster: Q9Y2W2 |
Function
for WBP11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: WBP11_HUMAN, Q9Y2W2Function: Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP11 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
WBP11 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for WBP11:
|
Pathways & Interactions
for WBP11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for WBP11):
WBP11 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WBP11
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/40 Interacting proteins for WBP11 (Q9Y2W21, 2, 3 ENSP000002611674) via UniProtKB, MINT, STRING, and/or I2D (see all 40)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
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| MCRS1 | Q96EZ82, 3, ENSP000003496404 | MINT-68385 I2D:
score=5 STRING: ENSP00000349640 | | ARF1 | P840772, 3, ENSP000002721024 | MINT-64019 I2D:
score=4 STRING: ENSP00000272102 | | PCBP1 | Q153651, 3, ENSP000003055564 | EBI-714455,EBI-946095 I2D:
score=1 STRING: ENSP00000305556 | | PPP1CA | P621362, 3, ENSP000003260314 | MINT-8336914 I2D:
score=1 STRING: ENSP00000326031 | | SF3A2 | Q154282, 3, ENSP000002214944 | MINT-5205989 I2D:
score=1 STRING: ENSP00000221494 |
About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
WBP11 for ontologies About GeneDecksing
|
Drugs & Compounds
for WBP11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WBP11
Search CenterWatch for drugs/clinical trials and news about WBP11
|
Transcripts
for WBP11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WBP11 gene: NM_016312.2 Unigene Cluster for WBP11: WW domain binding protein 11 Hs.655138 [show with all ESTs]Unigene Representative Sequence: BC0235326 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000261167(uc001rci.3) ENST00000537574 ENST00000535638 ENST00000544764
ENST00000535328 ENST00000543316
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WBP11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WBP11 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WBP11 (NM_016312) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WBP11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WBP11 |
Additional cDNA sequence: AB029309.1 AF118023.1 AK297410.1 AK302244.1 BC001621.1 BC016441.2 BC023532.2 BX647347.1 12 DOTS entries: DT.115924 DT.95363239 DT.100818165 DT.86855315 DT.100701005 DT.121192941 DT.121192944 DT.121192945 DT.121192955 DT.95086905 DT.91871424 DT.95363237 24/379 AceView cDNA sequences (see all 379): AW207274 F03849 BQ440362 AI377028 BQ652182 CK724906 BF432415 N49351 BQ423310 BM459312 BM555043 BE018235 Z40647 CR607984 BQ773657 AA911444 BE888199 AA243007 AW580897 AI356662 BQ431422 F07603 BQ921292 BU728347
GeneLoc Exon Structure
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Expression
for WBP11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WBP11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See WBP11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WBP11
SOURCE GeneReport for Unigene cluster: Hs.655138
UniProtKB/Swiss-Prot: WBP11_HUMAN, Q9Y2W2Tissue specificity: Ubiquitous. Highly expressed in the heart, pancreas, kidney skeletal muscle, placenta and brain (atprotein level). Weakly expressed in liver and lung
SABiosciences Custom PCR Arrays for WBP11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WBP11
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP11 |
Orthologs
for WBP11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WBP11 gene from 9/24 species (see all 24) About this table
ENSEMBL Gene Tree for WBP11 (if available)
TreeFam Gene Tree for WBP11 (if available) |
Paralogs
for WBP11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WBP11 gene
- SF3A22 ZNF2072 SNRPC2
WBP11 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for WBP11
PGOHUM00000259278 PGOHUM00000240898 PGOHUM00000260179 PGOHUM00000260973
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Genomic Variants
for WBP11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WBP11 (14939410 - 14956474 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for WBP11
1 CNV: 86230
1 Indel: 11601 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WBP11 |
|
Disorders
/ Diseases
for WBP11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WBP11 for disorders About GeneDecksing
5  diseases for WBP11: About MalaCardsataxia tuberculosis mycobacterium tuberculosis pancreatic cancer
pancreatitis
Export disorders for WBP11 gene to outside databases
|
Publications
for WBP11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WBP11 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with WBP11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Association of two nuclear proteins, Npw38 and NpwBP, via the interaction between the WW domain and a novel proline-rich motif containing glycine and arginine. (PubMed id 10593949)1, 2, 3, 9 Komuro A.... Kato S. (1999)
- SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1. (PubMed id 14640981)1, 2, 9 Llorian M.... Bollen M. (2004)
- A nuclear SH3 domain-binding protein that colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. (PubMed id 11375989)1, 2, 9 Craggs G.... Kellie S. (2001)
- Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21). (PubMed id 19592703)1, 2, 9 Huang X.... Shi Y. (2009)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for WBP11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WBP11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WBP11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WBP11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WBP11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WBP11 gene:
Search GeneIP for patents involving WBP11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WBP11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | WBP11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP11 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WBP11 |
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