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WBP11 Gene

protein-coding   GIFtS: 53

GC12M014830
WW domain binding protein 11
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZp779M1063 2
NPWBP 1, 2, 3
NpwBP 3
SIPP1 1, 2
SNP70 3
WBP-11 3
Descriptions
Npw38-binding protein 3
Npw38-binding protein NpwBP 2
SH3 domain-binding protein SNP70 2, 3
WW domain binding protein 11 2
splicing factor, PQBP1 and PP1 interacting 2
External Ids
HGNC: 164611
Entrez Gene: 517292
UniProtKB: Q9Y2W23
Ensembl: ENSG000000844637
Search outside databases for aliases for WBP11 gene

Previous GC identifers: GC12M014679 GC12M015084 GC12M014839

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for WBP11:
This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate
filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the
mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a
nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP
complex may function as a component of an mRNA factory in the nucleus. [provided by RefSeq]

UniProtKB/Swiss-Prot: WBP11_HUMAN, Q9Y2W2
Function: May play a role in the regulation of pre-mRNA processing

Gene Wiki entry for WBP11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WBP11 gene  

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12.3

WBP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M014830:     (about GC identifiers)

Start:
14,830,679 bp from pter
End:
14,847,668 bp from pter
Size:
16,990 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000012.10  NT_009714.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WBP11_HUMAN, Q9Y2W2 (See protein sequence)
Recommended Name: WW domain-binding protein 11  
Size: 641 amino acids; 69998 Da
Subunit: Interacts via the PGR motif with PQBP1 in the nucleus
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly located in the nucleus with granular
heterogeneous distribution. Excluded from nucleoli in interphase cells, distributed throughout
cytoplasm in dividing cells. Co-localized with SC35 and U2B in the nucleus. In the cytoplasm,
associates with the intermediate filament protein vimentin
Secondary accessions: Q96AY8

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_057396.1  

    ENSEMBL proteins: 
    ENSP00000261167 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (WBP11)
    Human Recombinant Proteins from Abnova (WBP11)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus TAS10593949
    GO:0005737 cytoplasm IEA--
    GO:0016607 nuclear speck IEA--
    About this table

    Antibodies for WBP11: 
    Browse Antibodies Central at Invitrogen
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    Antibodies from Abcam (WBP11), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (WBP11)
    Novus Biologicals Antibodies for WBP11

    Assays for WBP11: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR019007 WW_dom-bd_prot_11


       GeneDecks  WBP11 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9Y2W2

    ProtoNet protein and cluster: Q9Y2W2

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WBP11)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (WBP11)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016312

                  Applied Biosystems Silencer® siRNAs for WBP11

                  Sigma-Aldrich siRNA for WBP11  
                         Sigma-Aldrich shRNA for WBP11  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for WBP11
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_016312
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_016312
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_016312 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_016312

    UniProtKB/Swiss-Prot: WBP11_HUMAN, Q9Y2W2
    Function: May play a role in the regulation of pre-mRNA processing

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003697 single-stranded DNA binding TAS10593949
    GO:0005515 protein binding IPI16713569
    GO:0008599 protein phosphatase type 1 regulator activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  WBP11 


    5/15 Interacting proteins for WBP11 (ENSP000002611673 Q9Y2W21, 2) via UniProtKB, MINT, and/or STRING (see all 15 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PQBP1O608282STRING (score=.995) MINT-2855501 MINT-2873564 MINT-2873583
    CD2BP2O954002STRING (score=.861) MINT-62650 MINT-62662
    PCBP1Q153651EBI-714455, EBI-946095
    ARF1P840772MINT-64019
    C5orf22Q49AR22MINT-67807
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364 rRNA processing IEA--
    GO:0006397 mRNA processing IEA--
    GO:0008380 RNA splicing IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for WBP11

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WBP11)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (WBP11)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016312

                  Sigma-Aldrich siRNA for WBP11  
                         Sigma-Aldrich shRNA for WBP11  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_016312  

    REFSEQ mRNAs for WBP11 gene: 

    NM_016312.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_016312  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_016312
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_016312
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_016312 

    Additional cDNA sequence: 

    AB029309.1 AF118023.1 AK297410.1 AK302244.1 BC001621.1 BC016441.2 BC023532.2 BX647347.1 
    CR607984.1 

    13 DOTS entries:

    DT.115924  DT.95363239  DT.100818165  DT.86855315  DT.121192945  DT.100701005  DT.121192941  DT.121192942 
    DT.121192944  DT.121192955  DT.95086905  DT.95363237  DT.91871424 

    24/379 AceView cDNA sequences (see all 379 ):

    R95989 BQ424923 H80581 BQ644104 BI088960 BU196903 BX475972 BE281472 
    BM712889 BF432415 BE888199 BQ921292 Z39420 BQ440362 AA243007 AW207274 
    AI003525 BQ880814 BQ773657 AW575480 AA911444 BM741910 BQ423310 CA428476 

    highest scoring ESTs for WBP11:

    AA176178 AA206624 AA227847 AB029309 AF118023 AL517361 AL598881 AL601087 AW407205 AW961060 

    Unigene Cluster for WBP11:

    WW domain binding protein 11
    Hs.655138  [show with all ESTs]
    Unigene Representative Sequence: BC023532


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000261167  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    WBP11 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for WBP11

    1 / 2 / 3

    6 probe-sets matching WBP11 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    48983_at2, 3 U95-C 2 0.94 0.73 0.59 1.40 W23228 0.40 1.00 0.76 1

    75895_at2, 3 U95-E 3 0.62 0.72 0.98 0.62 AI040356 0.60 1.00 0.82 1

    217822_at2, 3 U133-A 2 1.00 0.68 -- -- NM_016312 0.60 1.00 0.82 1

    217821_s_at2, 3 U133-A 3 1.00 0.65 -- -- AF118023 0.80 1.00 0.91 1

    217822_at2 U133Plus2 2 1.00 0.68 -- -- -- -- -- -- --

    217821_s_at2 U133Plus2 3 1.00 0.65 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.655138

    UniProtKB/Swiss-Prot: WBP11_HUMAN, Q9Y2W2
    Tissue specificity: Ubiquitous. Highly expressed in the heart, pancreas, kidney skeletal muscle,
    placenta and brain (at protein level). Weakly expressed in liver and lung

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for WBP11 gene from 5/12 species (see all 12 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    WBP111   -- WW domain binding protein 11 94.38(n)
    98.75(a)
    609794  XM_847932.1  XP_853025.1 
    chimpanzee
    (Pan troglodytes)
    WBP111   -- WW domain binding protein 11 99.9(n)
    99.84(a)
    465307  XM_001157988.1  XP_001157988.1 
    cow
    (Bos taurus)
    WBP111   -- WW domain binding protein 11 90.49(n)
    94.2(a)
    512838  XM_590423.3  XP_590423.2 
    rat
    (Rattus norvegicus)
    Wbp111   -- WW domain binding protein 11 88.56(n)
    95.63(a)
    297695  NM_001009661.1  NP_001009661.1 
    mouse
    (Mus musculus)
    Wbp111, 5 6 (66.50 cM)5
    WW domain binding protein 111, 5 88.92(n)1
    95.16(a)1
    603211  NM_021714.31  NP_068360.31 
     AA4094665  AA4094675  (see all 23)
    About this table        Species with no ortholog for WBP11

    ENSEMBL Gene Tree for WBP11
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for WBP11 gene
    ZNF2072  

    Pseudogenes
    2 related pseudogenes


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/64 NCBI SNPs in WBP11 are shown (see all 64 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 47)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs79645991,2
    A,C,F,H14830276(+) CACACC/AAAACC 1 -- ng513Minor allele frequency- A:0.21EA WA 296
    rs64887121,2
    A,C,F14830599(+) TTAAAA/GACCCA 1 -- ng512Minor allele frequency- G:0.39NA 182
    --
    rs116113461,2
    C,H14838776(+) GCCTAC/TGAGGG 1 R/H mis1 ese34Minor allele frequency- T:0.00EU EA WA 404
    rs10519101,2
    H14830376(-) CTTGAA/GCTGAT 1 -- ng515Minor allele frequency- G:0.00MN EU EA WA 592
    --
    rs79713961,2
    A,C14834784(+) GACTGC/TGGCGG 1 P/P syn1 ese30--------
    rs73140751,2
    A,C,F,H14836684(+) AGTGAG/ATATCA 1 -- int12Minor allele frequency- A:0.09EA 166
    rs64887131,2
    A,C,F,H14834183(+) TTCAAA/GCTGAA 1 -- int112Minor allele frequency- G:0.43EA NA EU WA 1042
    rs116144451,2
    A,C,F,H14840029(+) CTATGT/CTGAAT 1 -- int18Minor allele frequency- C:0.06EU EA WA 834
    rs10126821,2
    C,F,H,O14842608(-) TTGTCT/CTGCTA 1 -- int19Minor allele frequency- C:0.16MN EU EA WA NA 964
    rs10126831,2
    A,C,F,H14842317(-) ATAAAC/TTTGTT 1 -- int14Minor allele frequency- T:0.48EU EA WA 408
    About this table

    HapMap Linkage Disequilibrium images for WBP11 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/14 PubMed articles for WBP11 gene (see all 14 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 51729 HGNC: 16461 AceView: WBP11 Ensembl:ENSG00000084463 euGenes: HUgn51729
    ECgene: WBP11 H-InvDB: WBP11
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for WBP11:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Lentivirus-delivered shRNAs for WBP11 Browse small molecules at Sigma-Aldrich
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     Antibodies for WBP11

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