Aliases for WBP1 Gene
External Ids for WBP1 Gene
- HGNC: 12737
- Entrez Gene: 23559
- Ensembl: ENSG00000239779
- OMIM: 606961
- UniProtKB: Q96G27
Previous GeneCards Identifiers for WBP1 Gene
- GC02P074823
- GC02P074643
- GC02P074660
- GC02P074597
- GC02P074539
- GC02P074685
- GC02P074421
Summaries for WBP1 Gene
-
The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various structural and regulatory proteins, is known to play a role in the mediation of protein-protein interactions. This gene encodes a ligand of the WW domain of the Yes kinase-associated protein. Readthrough transcription of the neighboring upstream gene, which encodes INO80 complex subunit B, into this gene generates a non-coding transcript. [provided by RefSeq, Feb 2011]
GeneCards Summary for WBP1 Gene
WBP1 (WW Domain Binding Protein 1) is a Protein Coding gene. Among its related pathways are CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF). GO annotations related to this gene include WW domain binding. An important paralog of this gene is WBP1L.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WBP1 Gene
Genomics for WBP1 Gene
Regulatory Elements for WBP1 Gene
Enhancers for WBP1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around WBP1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for WBP1 Gene
- Chromosome:
- 2
- Start:
- 74,458,329 bp from pter
- End:
- 74,460,891 bp from pter
- Size:
- 2,563 bases
- Orientation:
- Plus strand
Genomic View for WBP1 Gene
Genes around WBP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p13.1 by Ensembl
- 2p13.1 by Entrez Gene
- 2p13.1 by HGNC
WBP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for WBP1 Gene
Proteins for WBP1 Gene
-
Protein details for WBP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96G27-WBP1_HUMAN
- Recommended name:
- WW domain-binding protein 1
- Protein Accession:
- Q96G27
- B2RE02
- O95637
Protein attributes for WBP1 Gene
- Size:
- 269 amino acids
- Molecular mass:
- 29140 Da
- Quaternary structure:
-
- Interacts with NEDD4 (By similarity). Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with WWOX.
- SequenceCaution:
-
- Sequence=AAD10950.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for WBP1 Gene
Post-translational modifications for WBP1 Gene
Other Protein References for WBP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for WBP1
- Novus Biologicals Antibodies for WBP1
- Invitrogen Antibodies for WBP1
- antibodies-online Antibodies for WBP1: See all 11
- Search GeneTex for Antibodies for WBP1
Protein Products
-
OriGene Purified Proteins for WBP1
- Search Origene for MassSpec and Protein Over-expression Lysates for WBP1
- Origene Custom Protein Services for WBP1
- antibodies-online Proteins for WBP1: See all 11
- Search antibodies-online for peptides
- Search GeneTex for Proteins for WBP1
-
ProSci Proteins for WBP1
No data available for DME Specific Peptides for WBP1 Gene
Domains & Families for WBP1 Gene
Suggested Antigen Peptide Sequences for WBP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96G27UniProtKB/Swiss-Prot:
WBP1_HUMAN :- The WW-binding 2 motif mediates interaction with WWOX. Both WW-binding motifs mediate interaction with NEDD4 (By similarity).
- Domain:
-
- The WW-binding 2 motif mediates interaction with WWOX. Both WW-binding motifs mediate interaction with NEDD4 (By similarity).
No data available for Gene Families for WBP1 Gene
Function for WBP1 Gene
Molecular function for WBP1 Gene
- GENATLAS Biochemistry:
- WW domain binding protein 1,proline-rich ligand of YES-associated,putatively involved in protein-protein interaction
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15064722 |
| GO:0050699 | WW domain binding | IEA,ISS | -- |
Phenotypes for WBP1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for WBP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for WBP1 gene
- Search ViGene Biosciences for WBP1
CRISPR Products
-
OriGene CRISPR knockouts for WBP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for WBP1
- GenScript: Design CRISPR guide RNA sequences for WBP1
miRNA for WBP1 Gene
- miRTarBase miRNAs that target WBP1
miRNA Products
- Search ViGene Biosciences for WBP1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for WBP1
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-
ViGene Biosciences ready-to-package AAV shRNAs for WBP1 gene
Clone Products
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- VectorBuilder custom plasmid, inducible vectors for WBP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for WBP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for WBP1
-
ViGene Biosciences adenoviral particle packaged cDNA for WBP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for WBP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for WBP1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WBP1 Gene
Localization for WBP1 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for WBP1 Gene
Pathways & Interactions for WBP1 Gene
Pathways by source for WBP1 Gene
1 GeneGo (Thomson Reuters) pathway for WBP1 Gene
Interacting Proteins for WBP1 Gene
Selected Interacting proteins:
Q96G27-WBP1_HUMAN
ENSP00000233615
for WBP1 Gene via
IID
UniProtKB
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
No data available for SIGNOR curated interactions for WBP1 Gene
Transcripts for WBP1 Gene
mRNA/cDNA for WBP1 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (476) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for WBP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for WBP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for WBP1
- GenScript: Design CRISPR guide RNA sequences for WBP1
miRNA Products
- Search ViGene Biosciences for WBP1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for WBP1
- Browse OriGene Inhibitory RNA Products For WBP1
-
ViGene Biosciences ready-to-package AAV shRNAs for WBP1 gene
Clone Products
- Sino Biological Human cDNA Clone for WBP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for WBP1
- VectorBuilder custom plasmid, inducible vectors for WBP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for WBP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for WBP1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WBP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of WBP1 Gene:
WBP1SOURCE GeneReport for Unigene cluster for WBP1 Gene:
Hs.516114mRNA Expression by UniProt/SwissProt for WBP1 Gene:
Q96G27-WBP1_HUMAN
Tissue specificity:
Expressed in most tissues but at significantly lower levels in placenta, lung, liver, and kidney.
Evidence on tissue expression from TISSUES for WBP1 Gene
- Eye(4.6)
- Lung(4.6)
- Nervous system(4.5)
- Pancreas(4.4)
- Skin(3.5)
- Kidney(2.5)
- Muscle(2.3)
- Intestine(2)
- Liver(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for WBP1
-
OriGene qPCR primer pairs for WBP1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for WBP1 Gene
Orthologs for WBP1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | WBP1 34 |
|
||
| dog (Canis familiaris) |
Mammalia | WBP1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | WBP1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Wbp1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Wbp1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | WBP1 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | WBP1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.5133 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:77391 34 |
|
||
| WBP1 35 |
|
OneToOne | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2554 35 |
|
OneToMany |
- Species where no ortholog for WBP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for WBP1 Gene
(1) SIMAP similar genes for WBP1 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for WBP1 Gene
Variants for WBP1 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs368859958 | Uncertain significance | 74,461,355(+) | ATCGC(A/C/G)GTCAC | downstream-variant-500B, reference, missense | |
| rs886056337 | Uncertain significance | 74,461,110(-) | TGAAT(A/G)TGAAT | downstream-variant-500B, utr-variant-3-prime | |
| rs1000448439 | -- | 74,461,214(+) | CAGAA(C/G)CCTTT | downstream-variant-500B, utr-variant-3-prime | |
| rs1001347317 | -- | 74,457,113(+) | TAAAG(C/T)TAAAT | intron-variant, upstream-variant-2KB | |
| rs1001842485 | -- | 74,456,842(+) | GTTGC(C/T)TTAAC | intron-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.98;
36.68% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for WBP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- WBP1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WBP1 Gene
Disorders for WBP1 Gene
Relevant External Links for WBP1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- WBP1
No disorders were found for WBP1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WBP1 Gene
Publications for WBP1 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. (PMID: 15064722) Ludes-Meyers J.H. … Aldaz C.M. (Oncogene 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PMID: 9169421) Pirozzi G. … Fowlkes D.M. (J. Biol. Chem. 1997) 3 4 64
- Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands. (PMID: 9202023) Chen H.I. … Sudol M. (J. Biol. Chem. 1997) 3 4 64
Products for WBP1 Gene
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- Custom Antibody ServicesOriGene Antibodies for WBP1
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- Novus Biologicals Antibodies for WBP1
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- Invitrogen Antibodies for WBP1
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- antibodies-online Antibodies for WBP1: See all 11
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- Custom Antibody Services
- ProSci Proteins for WBP1
- Horizon Cell Lines for WBP1
- Cyagen custom Knockout/knockin (KOKI) mouse models for WBP1
- VectorBuilder custom plasmid, inducible vectors for WBP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for WBP1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for WBP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
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- (136) ViGene Biosciences
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- (141) ENCODE
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