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Aliases & Descriptions for WBP1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MGC15305 2 | | WBP-1 1, 2, 3 |
| | | Descriptions |
|---|
| WW domain binding protein 1 2 |
|
| | Search outside databases for aliases for WBP1 genePrevious GC identifers: GC02P074823 GC02P074643 GC02P074660 GC02P074597 |
Summaries for WBP1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for WBP1: The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by a conserved region: XPPXY motif. The function of this protein has not been determined. [provided by RefSeq] Gene Wiki entry for WBP1 |
Genomic Location for WBP1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the WBP1 gene 
Entrez Gene cytogenetic band: 2p12 Ensembl cytogenetic band: 2p13.1 HGNC cytogenetic band: 2p12WBP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P074539:
(about GC identifiers)
Start:
|
74,539,035 bp from pter |
End:
|
74,541,526 bp from pter |
Size:
|
2,492 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022184.14
| Proteins for WBP1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: WBP1_HUMAN, Q96G27 (See
protein sequence)Recommended Name: WW domain-binding protein 1 Size: 269 amino acids; 29140 Da
Subunit: Interacts with NEDD4 (By similarity). Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with WWOX
Secondary accessions: O95637REFSEQ proteins: NP_036609.1
ENSEMBL proteins: ENSP00000377542 ENSP00000386812 ENSP00000233615
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
ISS | -- | About this table
Antibodies for WBP1: Assays for WBP1: | Protein
Domains/ Families for WBP1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96G27 UniProtKB/Swiss-Prot: WBP1_HUMAN, Q96G27Domain: The WW-binding 2 motif mediates interaction with WWOX. Both WW-binding motifs mediate interaction with NEDD4 (By similarity) | Gene Function for WBP1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012477
Applied Biosystems Silencer® siRNAs for WBP1
Sigma-Aldrich siRNA for WBP1  Sigma-Aldrich shRNA for WBP1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012477                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012477                                  untagged cDNA clones in CMV expression vector (see all 2): NM_012477 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_012477
Genatlas biochemistry entry for WBP1:WW domain binding protein 1,proline-rich ligand of YES-associated,putatively involved in protein-protein interaction2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for WBP1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for WBP1 (ENSP000002336153) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | About this table
|
Drugs & Compounds for WBP1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for WBP1
|
Transcripts for WBP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012477
Sigma-Aldrich siRNA for WBP1  Sigma-Aldrich shRNA for WBP1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_012477 REFSEQ mRNAs for WBP1 gene: NM_012477.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_012477               OriGene GFP tagged cDNA clone in CMV expression vector: NM_012477                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012477                                  untagged cDNA clones in CMV expression vector (see all 2): NM_012477  Additional cDNA sequence: AF087888.1 AK315745.1 BC010012.2 BC064482.1 BC071626.1 BC071850.1 CR607952.1 CR618691.1 CR619748.1 CR626166.1 23 DOTS entries: DT.448998 DT.102838859 DT.97855593 DT.100823652 DT.100761862 DT.86844063 DT.92329533 DT.121000347 DT.97855586 DT.95246365 DT.91766125 DT.95375871 DT.100823659 DT.121025796 DT.97855592 DT.100823657 DT.100823658 DT.120976880 DT.91640932 DT.97803186 DT.100823651 DT.100823662 DT.95375873 24/476 AceView cDNA sequences (see all 476
):W05329 CR618691 AW026209 BX397181 CK430963 CB854866 BC010012 BQ574774 CR626166 BM672983 CR619748 CD675378 AW001353 BG757152 BC039617 BC064425 AI918863 AI871034 AI291350 AI299347 AA308975 NM_031288 BU733172 AI382209
highest scoring ESTs for WBP1:AA887990 AA039492 AA041546 AA083263 AA224332 AA308974 AA308975 AA362297 AA375056 AA393844 Unigene Cluster for WBP1: WW domain binding protein 1 Hs.516114 [show with all ESTs]Unigene Representative Sequence: BM811212
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations: ENST00000393972
ENST00000409737
ENST00000233615
|
Expression for WBP1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| WBP1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for WBP1
1 / 2 / 3 3 probe-sets matching WBP1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGGCTGTCTT
SOURCE GeneReport for Unigene cluster: Hs.516114 UniProtKB/Swiss-Prot: WBP1_HUMAN, Q96G27Tissue specificity: Expressed in most tissues but at significantly lower levels in placenta, lung, liver, and kidney |
Orthologs for WBP1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for WBP1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for WBP1
ENSEMBL Gene Tree for WBP1 | Paralogs for WBP1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for WBP1 gene
- C10orf262
|
SNPs/Variants for WBP1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
The following additional 22 SNP(s) have been
found in Applied Biosystems data source: (Click
for
Applied Biosystems TaqMan ® Genotyping Assay)
HapMap Linkage Disequilibrium images for WBP1 (up to first 250kb)
|
Disorders & Mutations for WBP1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606961
|
Medical News for WBP1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for WBP1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 9 PubMed articles for WBP1 gene: |
Search for WBP1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing WBP1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing WBP1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WBP1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for WBP1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for WBP1:

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| | Recombinant Proteins (WBP1) | | Antibodies (WBP1) |
| | | Search Tocris compounds for WBP1 |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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