Aliases for WBP1 Gene
External Ids for WBP1 Gene
- HGNC: 12737
- Entrez Gene: 23559
- Ensembl: ENSG00000239779
- OMIM: 606961
- UniProtKB: Q96G27
Previous GeneCards Identifiers for WBP1 Gene
- GC02P074823
- GC02P074643
- GC02P074660
- GC02P074597
- GC02P074539
- GC02P074685
- GC02P074421
Summaries for WBP1 Gene
-
The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various structural and regulatory proteins, is known to play a role in the mediation of protein-protein interactions. This gene encodes a ligand of the WW domain of the Yes kinase-associated protein. Readthrough transcription of the neighboring upstream gene, which encodes INO80 complex subunit B, into this gene generates a non-coding transcript. [provided by RefSeq, Feb 2011]
GeneCards Summary for WBP1 Gene
WBP1 (WW Domain Binding Protein 1) is a Protein Coding gene. Among its related pathways are CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF). Gene Ontology (GO) annotations related to this gene include WW domain binding. An important paralog of this gene is WBP1L.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WBP1 Gene
Genomics for WBP1 Gene
GeneHancer (GH) Regulatory Elements for WBP1 Gene
Regulatory Element Products
Genomic Locations for WBP1 Gene
- chr2:74,458,329-74,460,891
- (GRCh38/hg38)
- Size:
- 2,563 bases
- Orientation:
- Plus strand
- chr2:74,685,456-74,688,018
- (GRCh37/hg19)
Genomic View for WBP1 Gene
- Cytogenetic band:
-
- 2p13.1 by Ensembl
- 2p13.1 by Entrez Gene
- 2p13.1 by HGNC


RefSeq DNA sequence for WBP1 Gene
Proteins for WBP1 Gene
-
Protein details for WBP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96G27-WBP1_HUMAN
- Recommended name:
- WW domain-binding protein 1
- Protein Accession:
- Q96G27
- B2RE02
- O95637
Protein attributes for WBP1 Gene
- Size:
- 269 amino acids
- Molecular mass:
- 29140 Da
- Quaternary structure:
-
- Interacts with NEDD4 (By similarity). Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with WWOX.
- SequenceCaution:
-
- Sequence=AAD10950.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for WBP1 Gene
Post-translational modifications for WBP1 Gene
Other Protein References for WBP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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Protein Products
-
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-
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-
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-
Abcam proteins for WBP1
Assay Products
- antibodies-online: Search results for available WBP1 related products ranked by validation data
No data available for DME Specific Peptides for WBP1 Gene
Domains & Families for WBP1 Gene
Gene Families for WBP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Suggested Antigen Peptide Sequences for WBP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96G27UniProtKB/Swiss-Prot:
WBP1_HUMAN :- The PPxY motif 2 mediates interaction with WWOX. Both PPxY motifs mediate interaction with NEDD4 (By similarity).
- Domain:
-
- The PPxY motif 2 mediates interaction with WWOX. Both PPxY motifs mediate interaction with NEDD4 (By similarity).
Function for WBP1 Gene
Molecular function for WBP1 Gene
- GENATLAS Biochemistry:
- WW domain binding protein 1,proline-rich ligand of YES-associated,putatively involved in protein-protein interaction
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 15064722 |
GO:0050699 | WW domain binding | IEA,ISS | -- |
Phenotypes for WBP1 Gene
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-
-
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CRISPR Products
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miRNA for WBP1 Gene
- miRTarBase miRNAs that target WBP1
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for WBP1
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
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-
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-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WBP1 Gene
Localization for WBP1 Gene
- Cytosol (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005575 | cellular_component | ND | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for WBP1 Gene
Pathways & Interactions for WBP1 Gene
Pathways by source for WBP1 Gene
1 GeneGo (Thomson Reuters) pathway for WBP1 Gene
Interacting Proteins for WBP1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008150 | biological_process | ND | -- |
No data available for SIGNOR curated interactions for WBP1 Gene
Transcripts for WBP1 Gene
mRNA/cDNA for WBP1 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (476) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for WBP1 Gene
CRISPR Products
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-
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for WBP1
- genomics-online: cdna clones - Search results for available WBP1 gene related products
- orf clones - Search results for available WBP1 gene related products
- Applied Biological Materials Clones for WBP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for WBP1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WBP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of WBP1 Gene:
WBP1SOURCE GeneReport for Unigene cluster for WBP1 Gene:
Hs.516114mRNA Expression by UniProt/SwissProt for WBP1 Gene:
Q96G27-WBP1_HUMANEvidence on tissue expression from TISSUES for WBP1 Gene
- Eye(4.6)
- Lung(4.6)
- Nervous system(4.5)
- Pancreas(4.4)
- Skin(3.5)
- Kidney(2.5)
- Muscle(2.3)
- Intestine(2)
- Liver(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for WBP1
-
OriGene qPCR primer pairs for WBP1
- genomics-online: primer clones - Search results for available WBP1 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for WBP1 Gene
Orthologs for WBP1 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | WBP1 33 |
|
||
dog (Canis familiaris) |
Mammalia | WBP1 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | WBP1 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Wbp1 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Wbp1 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | WBP1 34 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | WBP1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.5133 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | zgc:77391 33 |
|
||
WBP1 34 |
|
OneToOne | |||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2554 34 |
|
OneToMany |
- Species where no ortholog for WBP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for WBP1 Gene
(1) SIMAP similar genes for WBP1 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for WBP1 Gene
Variants for WBP1 Gene
SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs368859958 | uncertain-significance, not specified, Congenital disorder of glycosylation | 74,461,355(+) | G/A/C | downstream_transcript_variant | |
rs929416520 | uncertain-significance, Congenital disorder of glycosylation | 74,461,110(+) | C/T | downstream_transcript_variant | |
rs1000448439 | -- | 74,461,214(+) | G/C | downstream_transcript_variant | |
rs1001347317 | -- | 74,457,113(+) | C/T | upstream_transcript_variant | |
rs1001842485 | -- | 74,456,842(+) | T/C | upstream_transcript_variant |
Additional Variant Information for WBP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- WBP1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WBP1 Gene
Disorders for WBP1 Gene
Additional Disease Information for WBP1
No disorders were found for WBP1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WBP1 Gene
Publications for WBP1 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. (PMID: 15064722) Ludes-Meyers JH … Aldaz CM (Oncogene 2004) 3 4 58
- Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands. (PMID: 9202023) Chen HI … Sudol M (The Journal of biological chemistry 1997) 3 4 58
- Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PMID: 9169421) Pirozzi G … Fowlkes DM (The Journal of biological chemistry 1997) 3 4 58
Products for WBP1 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for WBP1
- antibodies-online: Search results for 17 available WBP1 Antibodies ranked by validation data
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Sources for WBP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
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- (114) diseasecard
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- (133) ENCODE
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- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew