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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WBP1 Gene

protein-coding   GIFtS: 47
GCID: GC02P074685

WW Domain Binding Protein 1
  5 related diseases
at
MalaCards
 

Aliases
for WBP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
WW Domain Binding Protein 11 2
WBP-12 3
WW Domain-Binding Protein 12

External Ids:    HGNC: 127371   Entrez Gene: 235592   Ensembl: ENSG000002397797   OMIM: 6069615   UniProtKB: Q96G273   

Export aliases for WBP1 gene to outside databases

Previous GC identifers: GC02P074823 GC02P074643 GC02P074660 GC02P074597 GC02P074539 GC02P074421


Summaries
for WBP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WBP1 Gene:
The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various
structural and regulatory proteins, is known to play a role in the mediation of protein-protein interactions.
This gene encodes a ligand of the WW domain of the Yes kinase-associated protein. Readthrough transcription of
the neighboring upstream gene, which encodes INO80 complex subunit B, into this gene generates a non-coding
transcript. (provided by RefSeq, Feb 2011)

GeneCards Summary for WBP1 Gene: 
WBP1 (WW domain binding protein 1) is a protein-coding gene. Diseases associated with WBP1 include congenital disorder of glycosylation, and macular degeneration. GO annotations related to this gene include protein binding and WW domain binding. An important paralog of this gene is WBP1L.

Gene Wiki entry for WBP1 Gene


Genomic Views
for WBP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WBP1 gene promoter:
         HOXA9   ER-alpha   GR   p53   GCNF   E47   GCNF-1   Hand1   GR-alpha   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WBP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for WBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p12

WBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WBP1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P074685:  view genomic region     (about GC identifiers)

Start:
 74,685,456 bp from pter      End:
 74,688,018 bp from pter
Size:
 2,563 bases      Orientation:
 plus strand

Proteins
for WBP1 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: WBP1_HUMAN, Q96G27 (See protein sequence)
Recommended Name: WW domain-binding protein 1  
Size: 269 amino acids; 29140 Da
Subunit: Interacts with NEDD4 (By similarity). Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with WWOX
Sequence caution: Sequence=AAD10950.1; Type=Erroneous initiation;
Secondary accessions: B2RE02 O95637

Explore the universe of human proteins at neXtProt for WBP1: NX_Q96G27

Explore proteomics data for WBP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96G27

    • WBP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WBP1 Protein Expression
    REFSEQ proteins: NP_036609.1  
    ENSEMBL proteins: 
     ENSP00000233615   ENSP00000377542   ENSP00000386812   ENSP00000408816  

    Human Recombinant Protein Products for WBP1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WBP1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    WBP1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for WBP1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 1 InterPro protein domain:
     IPR021684 Uncharacterised_WW-bd

    Graphical View of Domain Structure for InterPro Entry Q96G27

    ProtoNet protein and cluster: Q96G27

    UniProtKB/Swiss-Prot: WBP1_HUMAN, Q96G27
    Domain: The WW-binding 2 motif mediates interaction with WWOX. Both WW-binding motifs mediate interaction with
    NEDD4 (By similarity)


    WBP1 for domains           About GeneDecksing


    Function
    for WBP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:
         Genatlas biochemistry entry for WBP1:
    WW domain binding protein 1,proline-rich ligand of YES-associated,putatively involved in protein-protein
    interaction

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15064722
    GO:0050699WW domain binding ISS--
         
    WBP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for WBP1:
     Increased G2M DNA content  S arrest 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WBP1 
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    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate WBP1 (see all 13):
    hsa-miR-130a* hsa-miR-23c hsa-miR-621 hsa-miR-10b* hsa-miR-567 hsa-miR-23b hsa-miR-654-5p hsa-miR-130b*
    SwitchGear 3'UTR luciferase reporter plasmid: WBP1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Pathways & Interactions
    for WBP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WBP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
    		CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for WBP1
        CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/15 Interacting proteins for WBP1 (Q96G271, 3 ENSP000002336154) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WWP2O003083, ENSP000003482834I2D: score=2 STRING: ENSP00000348283
    YAP1P469373, ENSP000002824414I2D: score=3 STRING: ENSP00000282441
    NEDD4P469343, ENSP000003455304I2D: score=3 STRING: ENSP00000345530
    MAGI1Q96QZ73, ENSP000003854504I2D: score=1 STRING: ENSP00000385450
    WWP1Q9H0M03, ENSP000002654284I2D: score=2 STRING: ENSP00000265428
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    WBP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for WBP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WBP1

    Search CenterWatch for drugs/clinical trials and news about WBP1

    Transcripts
    for WBP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WBP1 gene: 
    NM_012477.3  

    Unigene Cluster for WBP1:

    WW domain binding protein 1
    Hs.516114  [show with all ESTs]
    Unigene Representative Sequence: BM811212
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233615(uc002slj.2) ENST00000393972 ENST00000474185 ENST00000466835
    ENST00000464774 ENST00000470536 ENST00000484744(uc002sll.2) ENST00000409737
    ENST00000428943 ENST00000494741 ENST00000473467 ENST00000466303 ENST00000492047
    ENST00000490120
    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate WBP1 (see all 13):
    hsa-miR-130a* hsa-miR-23c hsa-miR-621 hsa-miR-10b* hsa-miR-567 hsa-miR-23b hsa-miR-654-5p hsa-miR-130b*
    SwitchGear 3'UTR luciferase reporter plasmid: WBP1 3' UTR sequence
    Inhib. RNA
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WBP1

    Additional mRNA sequence: 

    AF087888.1 AK315745.1 BC010012.2 BC064482.1 BC071626.1 BC071850.1 

    23 DOTS entries:

    DT.448998  DT.102838859  DT.97855593  DT.100823652  DT.100761862  DT.86844063  DT.92329533  DT.121000347 
    DT.97855586  DT.95246365  DT.91766125  DT.95375871  DT.100823659  DT.121025796  DT.97855592  DT.100823657 
    DT.100823658  DT.120976880  DT.91640932  DT.97803186  DT.100823651  DT.100823662  DT.95375873 

    24/476 AceView cDNA sequences (see all 476):

    CA311215 CD513481 AA308974 AI918863 CA395821 BM976374 BE548803 BM909171 
    AI953144 BG757152 CR625948 BQ069051 BU169524 CK430963 AI871034 BM699864 
    BM921627 AW001353 AA580350 BM973607 BM470922 BF223045 BQ720263 BM707932 

    GeneLoc Exon Structure


    Expression
    for WBP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCTGTCTT
    WBP1 Expression
    About this image


    See WBP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WBP1

    SOURCE GeneReport for Unigene cluster: Hs.516114

    UniProtKB/Swiss-Prot: WBP1_HUMAN, Q96G27
    Tissue specificity: Expressed in most tissues but at significantly lower levels in placenta, lung, liver, and
    kidney

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    In Situ
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    Orthologs
    for WBP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for WBP1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Wbp11 , 5 WW domain binding protein 11, 5 87.73(n)1
    84.76(a)1    		   6 (35.94 cM)5
    223771  NM_001083922.11  NP_001077391.11 
     831190445 
    lizard
    (Anolis carolinensis)    		 Reptilia WBP16
    		 Uncharacterized protein
    		 33(a)
    		 1 ↔ 1
    		 GL344203.1(30373-39648)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.51332 Transcribed sequence with weak similarity to protein more 77.12(n)    BQ393819.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:773911 zgc:77391 61.49(n)
    56.32(a)    		   402930  NM_205634.1  NP_991197.1 


    ENSEMBL Gene Tree for WBP1 (if available)
    TreeFam Gene Tree for WBP1 (if available)

    Paralogs
    for WBP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WBP1 gene
    WBP1L2  
    1 SIMAP similar gene for WBP1 using alignment to 4 protein entries:     WBP1_HUMAN (see all proteins):
    WBP1L

    WBP1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for WBP1
    PGOHUM00000240128 PGOHUM00000240723


    Genomic Variants
    for WBP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    		Structural Variations
         Database of Genomic Variants (DGV) 4 variations for WBP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv458185CNV Loss19166990
    nsv515851CNV Loss19592680
    dgv4166n71CNV Loss21882294
    dgv1199e1CNV Complex17122850

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    Disorders / Diseases
    for WBP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 606961    OMIM disorders: --

    5 diseases for WBP1:    About MalaCards
    congenital disorder of glycosylation    macular degeneration    t-cell leukemia    ataxia
    leukemia


    WBP1 for disorders           About GeneDecksing


    Export disorders for WBP1 gene to outside databases

    Publications
    for WBP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WBP1 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with WBP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. (PubMed id 15064722)1, 2 Ludes-Meyers J.H....Aldaz C.M. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands. (PubMed id 9202023)1, 2 Chen H.I.... Sudol M. (1997)
    5. Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PubMed id 9169421)1, 2 Pirozzi G.... Fowlkes D.M. (1997)
    6. The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. (PubMed id 7644498)1, 3 Chen H.I. and Sudol M. (1995)
    7. Activating transcription factor-6 (ATF6) mediates apo ptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via i nduction of WW domain binding protein 1. (PubMed id 21841196)1 Morishima N....Nakano A. (2011)
    8. Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors. (PubMed id 21981024)1 McDonald C.B....Farooq A. (2011)
    9. Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (2011)
    10. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)

    External Searches for WBP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing WBP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23559 HGNC: 12737 AceView: WBP1andHMGA1L4 Ensembl:ENSG00000239779 euGenes: HUgn23559
    ECgene: WBP1 H-InvDB: WBP1

    Other Databases showing WBP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WBP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WBP1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for WBP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WBP1 gene:
    Search GeneIP for patents involving WBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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