WBP1 Gene
protein-coding GIFtS: 48
GCID: GC02P074685
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|
WW domain binding protein 1
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Aliases
for WBP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WW Domain Binding Protein 11 2 | | WBP-11 2 3 | | WW Domain-Binding Protein 12 |
Export aliases for WBP1 gene to outside databasesPrevious GC identifers: GC02P074823 GC02P074643 GC02P074660 GC02P074597 GC02P074539 GC02P074421 |
Summaries
for WBP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WBP1:
The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various structuraland regulatory proteins, is known to play a role in the mediation of protein-protein interactions. This gene encodes aligand of the WW domain of the Yes kinase-associated protein. Readthrough transcription of the neighboring upstreamgene, which encodes INO80 complex subunit B, into this gene generates a non-coding transcript. (provided by RefSeq,Feb 2011)
Gene Wiki entry for WBP1
|
Genomic Views
for WBP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WBP1 gene promoter:
HOXA9 ER-alpha GR p53 GCNF E47 GCNF-1 Hand1 GR-alpha GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for WBP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WBP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p12 Ensembl cytogenetic band: 2p13.1 HGNC cytogenetic band: 2p12WBP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P074685: view genomic region
(about GC identifiers)
Start:
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74,685,456 bp from pter |
End:
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74,688,018 bp from pter |
Size:
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2,563 bases |
Orientation:
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plus strand |
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Proteins
for WBP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WBP1_HUMAN, Q96G27 (See
protein sequence)Recommended Name: WW domain-binding protein 1 Size: 269 amino acids; 29140 Da
Subunit: Interacts with NEDD4 (By similarity). Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with WWOX
Sequence caution: Sequence=AAD10950.1; Type=Erroneous initiation;
Secondary accessions: B2RE02 O95637Explore the universe of human proteins at neXtProt for WBP1: NX_Q96G27
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96G27
WBP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036609.1
ENSEMBL proteins: ENSP00000233615 ENSP00000377542 ENSP00000386812 ENSP00000408816
Human Recombinant Protein Products for WBP1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
WBP1 for ontologies About GeneDecksing
WBP1 Antibody Products:
Assay Products for WBP1: |
Protein
Domains /
Families
for WBP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WBP1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96G27ProtoNet protein and cluster: Q96G27 UniProtKB/Swiss-Prot: WBP1_HUMAN, Q96G27Domain: The WW-binding 2 motif mediates interaction with WWOX. Both WW-binding motifs mediate interaction with NEDD4(By similarity) |
Function
for WBP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
Genatlas biochemistry entry for WBP1:WW domain binding protein 1,proline-rich ligand of YES-associated,putatively involved in protein-protein interaction
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
WBP1 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for WBP1:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WBP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: WBP1 (NM_012477) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WBP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WBP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP1 |
|
Pathways & Interactions
for WBP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  GeneGo (Thomson Reuters) Pathway for WBP1
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WBP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/15 Interacting proteins for WBP1 (Q96G271, 3 ENSP000002336154) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
WBP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for WBP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WBP1
Search CenterWatch for drugs/clinical trials and news about WBP1
|
Transcripts
for WBP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WBP1 gene: NM_012477.3 Unigene Cluster for WBP1: WW domain binding protein 1 Hs.516114 [show with all ESTs]Unigene Representative Sequence: BM81121214 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000233615(uc002slj.2) ENST00000393972 ENST00000474185 ENST00000466835
ENST00000464774 ENST00000470536 ENST00000484744(uc002sll.2) ENST00000409737
ENST00000428943 ENST00000494741 ENST00000473467 ENST00000466303 ENST00000492047
ENST00000490120
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WBP1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WBP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WBP1 (NM_012477) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WBP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WBP1 |
Additional cDNA sequence: AF087888.1 AK315745.1 BC010012.2 BC064482.1 BC071626.1 BC071850.1 23 DOTS entries: DT.448998 DT.102838859 DT.97855593 DT.100823652 DT.100761862 DT.86844063 DT.92329533 DT.121000347 DT.97855586 DT.95246365 DT.91766125 DT.95375871 DT.100823659 DT.121025796 DT.97855592 DT.100823657 DT.100823658 DT.120976880 DT.91640932 DT.97803186 DT.100823651 DT.100823662 DT.95375873 24/476 AceView cDNA sequences (see all 476): BM672983 BM670206 BM560764 BC064482 BM805624 BF726607 BC064425 CA418903 BF223045 BM921627 AI953144 CD513481 AW207170 BC039617 AI291350 AK094297 BC050666 NM_031288 BU169524 CK430508 AA652370 AI656663 AI955663 H19689
GeneLoc Exon Structure
|
Expression
for WBP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WBP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCTGTCTT
About this image
See WBP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WBP1
SOURCE GeneReport for Unigene cluster: Hs.516114
UniProtKB/Swiss-Prot: WBP1_HUMAN, Q96G27Tissue specificity: Expressed in most tissues but at significantly lower levels in placenta, lung, liver, and kidney
SABiosciences Custom PCR Arrays for WBP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WBP1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP1 |
Orthologs
for WBP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for WBP1 gene from 3/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
WBP16 |
-- |
45(a) |
1 ↔ 1 |
GL344203.1(31705-34046) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.51332 |
Transcribed sequence with weak similarity to protein more |
77.12(n) |
|
BQ393819.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:773911 |
zgc:77391 |
61.49(n)
56.32(a) |
|
402930 NM_205634.1 NP_991197.1 |
ENSEMBL Gene Tree for WBP1 (if available)
TreeFam Gene Tree for WBP1 (if available) |
Paralogs
for WBP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WBP1 gene
- WBP1L2
1 SIMAP similar gene for WBP1 using alignment to 4 protein entries: WBP1_HUMAN (see all proteins):WBP1L
WBP1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for WBP1
PGOHUM00000240128 PGOHUM00000240723
|
Genomic Variants
for WBP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WBP1 (74685456 - 74688018 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for WBP1
3 CNVs: 50556 3366 50558 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for WBP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WBP1 for disorders About GeneDecksing
OMIM gene information: 606961
OMIM disorders: --
5  diseases for WBP1: About MalaCardsmacular degeneration ptosis t-cell leukemia ataxia
leukemia
Export disorders for WBP1 gene to outside databases
|
Publications
for WBP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WBP1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with WBP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. (PubMed id 15064722)1, 2 Ludes-Meyers J.H....Aldaz C.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands. (PubMed id 9202023)1, 2 Chen H.I.... Sudol M. (1997)
- Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PubMed id 9169421)1, 2 Pirozzi G.... Fowlkes D.M. (1997)
- The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. (PubMed id 7644498)1, 3 Chen H.I. and Sudol M. (1995)
- Activating transcription factor-6 (ATF6) mediates apo ptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via i nduction of WW domain binding protein 1. (PubMed id 21841196)1 Morishima N....Nakano A. (2011)
- Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors. (PubMed id 21981024)1 McDonald C.B....Farooq A. (2011)
- Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (2011)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
|
External Searches for WBP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WBP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WBP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WBP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WBP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WBP1 gene:
Search GeneIP for patents involving WBP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WBP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WBP1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WBP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WBP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WBP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WBP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WBP1 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WBP1 |
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