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WBP1 Gene(Protein Coding)

WW Domain Binding Protein 1

GCID:
GC02P074458
GIFtS:
47
Genes Participants
UDN Logo

Aliases for WBP1 Gene

Aliases for WBP1 Gene

  • WW Domain Binding Protein 1 2 3 5
  • WBP-1 3 4

External Ids for WBP1 Gene

Previous GeneCards Identifiers for WBP1 Gene

  • GC02P074823
  • GC02P074643
  • GC02P074660
  • GC02P074597
  • GC02P074539
  • GC02P074685
  • GC02P074421

Summaries for WBP1 Gene

Entrez Gene Summary for WBP1 Gene

  • The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various structural and regulatory proteins, is known to play a role in the mediation of protein-protein interactions. This gene encodes a ligand of the WW domain of the Yes kinase-associated protein. Readthrough transcription of the neighboring upstream gene, which encodes INO80 complex subunit B, into this gene generates a non-coding transcript. [provided by RefSeq, Feb 2011]

GeneCards Summary for WBP1 Gene

WBP1 (WW Domain Binding Protein 1) is a Protein Coding gene. Among its related pathways are CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF). GO annotations related to this gene include WW domain binding. An important paralog of this gene is WBP1L.

Gene Wiki entry for WBP1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WBP1 Gene

Genomics for WBP1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for WBP1 Gene

Enhancers for WBP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WBP1 on UCSC Golden Path with GeneCards custom track

Promoters for WBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WBP1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the WBP1 gene promoter:

Genomic Location for WBP1 Gene

Chromosome:
2
Start:
74,458,329 bp from pter
End:
74,460,891 bp from pter
Size:
2,563 bases
Orientation:
Plus strand

Genomic View for WBP1 Gene

Genes around WBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WBP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for WBP1 Gene

Proteins for WBP1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for WBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G27-WBP1_HUMAN
    Recommended name:
    WW domain-binding protein 1
    Protein Accession:
    Q96G27
    Secondary Accessions:
    • B2RE02
    • O95637

    Protein attributes for WBP1 Gene

    Size:
    269 amino acids
    Molecular mass:
    29140 Da
    Quaternary structure:
    • Interacts with NEDD4 (By similarity). Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with WWOX.
    SequenceCaution:
    • Sequence=AAD10950.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for WBP1 Gene

neXtProt entry for WBP1 Gene

Proteomics data for WBP1 Gene at MOPED

Protein Expression for WBP1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for WBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WBP1 Gene

Domains & Families for WBP1 Gene

Protein Domains for WBP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96G27

UniProtKB/Swiss-Prot:

WBP1_HUMAN :
  • The WW-binding 2 motif mediates interaction with WWOX. Both WW-binding motifs mediate interaction with NEDD4 (By similarity).
Domain:
  • The WW-binding 2 motif mediates interaction with WWOX. Both WW-binding motifs mediate interaction with NEDD4 (By similarity).
genes like me logo Genes that share domains with WBP1: view

No data available for Gene Families for WBP1 Gene

Function for WBP1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for WBP1 Gene

GENATLAS Biochemistry:
WW domain binding protein 1,proline-rich ligand of YES-associated,putatively involved in protein-protein interaction

Gene Ontology (GO) - Molecular Function for WBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15064722
genes like me logo Genes that share ontologies with WBP1: view

Phenotypes for WBP1 Gene

GenomeRNAi human phenotypes for WBP1:
genes like me logo Genes that share phenotypes with WBP1: view

Animal Model Products

miRNA for WBP1 Gene

miRTarBase miRNAs that target WBP1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WBP1 Gene

Localization for WBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WBP1 Gene COMPARTMENTS Subcellular localization image for WBP1 gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for WBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with WBP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WBP1 Gene

Pathways & Interactions for WBP1 Gene

genes like me logo Genes that share pathways with WBP1: view

Pathways by source for WBP1 Gene

1 GeneGo (Thomson Reuters) pathway for WBP1 Gene

Gene Ontology (GO) - Biological Process for WBP1 Gene

None

No data available for SIGNOR curated interactions for WBP1 Gene

Drugs & Compounds for WBP1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for WBP1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for WBP1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(476) Selected AceView cDNA sequences:
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WBP1 Gene

WW domain binding protein 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WBP1 Gene

No ASD Table

Relevant External Links for WBP1 Gene

GeneLoc Exon Structure for
WBP1
ECgene alternative splicing isoforms for
WBP1

Expression for WBP1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for WBP1 Gene

mRNA expression in normal human tissues for WBP1 Gene
mRNA expression by GTEx for WBP1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WBP1 Gene



SOURCE GeneReport for Unigene cluster for WBP1 Gene Hs.516114

mRNA Expression by UniProt/SwissProt for WBP1 Gene

Q96G27-WBP1_HUMAN
Tissue specificity: Expressed in most tissues but at significantly lower levels in placenta, lung, liver, and kidney.
genes like me logo Genes that share expression patterns with WBP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for WBP1 Gene

Orthologs for WBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia WBP1 35
  • 88.72 (n)
  • 85.87 (a)
WBP1 36
  • 85 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia WBP1 35
  • 89.14 (n)
  • 87.27 (a)
WBP1 36
  • 85 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Wbp1 35
  • 87.73 (n)
  • 84.76 (a)
Wbp1 16
Wbp1 36
  • 73 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia WBP1 35
  • 98.51 (n)
  • 97.77 (a)
rat
(Rattus norvegicus)
 Mammalia Wbp1 35
  • 87.24 (n)
  • 84.39 (a)
oppossum
(Monodelphis domestica)
 Mammalia WBP1 36
  • 56 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia WBP1 36
  • 35 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia Str.5133 35
zebrafish
(Danio rerio)
 Actinopterygii zgc:77391 35
  • 61.3 (n)
  • 55.17 (a)
WBP1 36
  • 26 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.2554 36
  • 34 (a)
 OneToMany
Species with no ortholog for WBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WBP1 Gene

ENSEMBL:
Gene Tree for WBP1 (if available)
TreeFam:
Gene Tree for WBP1 (if available)

Paralogs for WBP1 Gene

Paralogs for WBP1 Gene

(1) SIMAP similar genes for WBP1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for WBP1 Gene

genes like me logo Genes that share paralogs with WBP1: view

Variants for WBP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for WBP1 Gene

Variant ID Type Subtype PubMed ID
dgv1199e1 CNV Complex 17122850
nsv458185 CNV Loss 19166990
nsv515851 CNV Loss 19592680
dgv4166n71 CNV Loss 21882294

Variation tolerance for WBP1 Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.68% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for WBP1 Gene

Disorders for WBP1 Gene

Relevant External Links for WBP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WBP1

No disorders were found for WBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WBP1 Gene

Publications for WBP1 Gene

  1. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. (PMID: 15064722) Ludes-Meyers J.H. … Aldaz C.M. (Oncogene 2004) 3 4 67
  2. The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. (PMID: 7644498) Chen H.I. … Sudol M. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3
  3. COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. (PMID: 25894502) Watkin L.B. … Shum A.K. (Nat. Genet. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity. (PMID: 25283809) Schuchardt B.J. … Farooq A. (FEBS J. 2014) 3

Products for WBP1 Gene

  • Addgene plasmids for WBP1

Sources for WBP1 Gene

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