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WBP1 Gene

protein-coding   GIFtS: 48
GCID: GC02P074685

WW Domain Binding Protein 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WW Domain Binding Protein 11 2
WBP-12 3
WW Domain-Binding Protein 12

External Ids:    HGNC: 127371   Entrez Gene: 235592   Ensembl: ENSG000002397797   OMIM: 6069615   UniProtKB: Q96G273   

Export aliases for WBP1 gene to outside databases

Previous GC identifers: GC02P074823 GC02P074643 GC02P074660 GC02P074597 GC02P074539 GC02P074421


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WBP1 Gene:
The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various
structural and regulatory proteins, is known to play a role in the mediation of protein-protein interactions.
This gene encodes a ligand of the WW domain of the Yes kinase-associated protein. Readthrough transcription of
the neighboring upstream gene, which encodes INO80 complex subunit B, into this gene generates a non-coding
transcript. (provided by RefSeq, Feb 2011)

GeneCards Summary for WBP1 Gene:
WBP1 (WW domain binding protein 1) is a protein-coding gene. GO annotations related to this gene include WW domain binding. An important paralog of this gene is WBP1L.

Gene Wiki entry for WBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the WBP1 gene promoter:
         HOXA9   ER-alpha   GR   p53   GCNF   E47   GCNF-1   Hand1   GR-alpha   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWBP1 promoter sequence
   Search Chromatin IP Primers for WBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p12

WBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WBP1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P074685:  view genomic region     (about GC identifiers)

Start:
74,685,456 bp from pter      End:
74,688,018 bp from pter
Size:
2,563 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WBP1_HUMAN, Q96G27 (See protein sequence)
Recommended Name: WW domain-binding protein 1  
Size: 269 amino acids; 29140 Da
Subunit: Interacts with NEDD4 (By similarity). Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with WWOX
Sequence caution: Sequence=AAD10950.1; Type=Erroneous initiation;
Secondary accessions: B2RE02 O95637

Explore the universe of human proteins at neXtProt for WBP1: NX_Q96G27

Explore proteomics data for WBP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036609.1  
    ENSEMBL proteins: 
     ENSP00000233615   ENSP00000377542   ENSP00000386812   ENSP00000408816  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR021684 Uncharacterised_WW-bd

    Graphical View of Domain Structure for InterPro Entry Q96G27

    ProtoNet protein and cluster: Q96G27

    UniProtKB/Swiss-Prot: WBP1_HUMAN, Q96G27
    Domain: The WW-binding 2 motif mediates interaction with WWOX. Both WW-binding motifs mediate interaction with
    NEDD4 (By similarity)


    Find genes that share domains with WBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for WBP1:
    WW domain binding protein 1,proline-rich ligand of YES-associated,putatively involved in protein-protein
    interaction

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15064722
    GO:0050699WW domain binding ISS--
         
    Find genes that share ontologies with WBP1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for WBP1:
     Increased G2M DNA content  S arrest 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for WBP1

    miRNA
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    miRTarBase miRNAs that target WBP1:
    hsa-mir-335-5p (MIRT018120)

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    Selected qRT-PCR Assays for microRNAs that regulate WBP1 (see all 13):
    hsa-miR-130a* hsa-miR-23c hsa-miR-621 hsa-miR-10b* hsa-miR-567 hsa-miR-23b hsa-miR-654-5p hsa-miR-130b*
    SwitchGear 3'UTR luciferase reporter plasmidWBP1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    plasma membrane3
    endoplasmic reticulum1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with WBP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WBP1 About    
    See pathways by source

    SuperPathContained pathways About
    1CFTR dependent regulation of ion channels in Airway Epithelium norm and CF
    CFTR dependent regulation of ion channels in Airway Epithelium norm and CF

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for WBP1
        CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WBP1
    Interactions:

        Search GeneGlobe Interaction Network for WBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for WBP1 (Q96G271, 3 ENSP000002336154) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WWP2O003083, ENSP000003482834I2D: score=2 STRING: ENSP00000348283
    YAP1P469373, ENSP000002824414I2D: score=3 STRING: ENSP00000282441
    NEDD4P469343, ENSP000003455304I2D: score=3 STRING: ENSP00000345530
    MAGI1Q96QZ73, ENSP000003854504I2D: score=1 STRING: ENSP00000385450
    WWP1Q9H0M03, ENSP000002654284I2D: score=2 STRING: ENSP00000265428
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with WBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for WBP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WBP1 gene: 
    NM_012477.3  

    Unigene Cluster for WBP1:

    WW domain binding protein 1
    Hs.516114  [show with all ESTs]
    Unigene Representative Sequence: BM811212
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233615(uc002slj.2) ENST00000393972 ENST00000474185 ENST00000466835
    ENST00000464774 ENST00000470536 ENST00000484744(uc002sll.2) ENST00000409737
    ENST00000428943 ENST00000494741 ENST00000473467 ENST00000466303 ENST00000492047
    ENST00000490120
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    hsa-miR-130a* hsa-miR-23c hsa-miR-621 hsa-miR-10b* hsa-miR-567 hsa-miR-23b hsa-miR-654-5p hsa-miR-130b*
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    Additional mRNA sequence: 

    AF087888.1 AK315745.1 BC010012.2 BC064482.1 BC071626.1 BC071850.1 

    23 DOTS entries:

    DT.448998  DT.102838859  DT.97855593  DT.100823652  DT.100761862  DT.86844063  DT.92329533  DT.121000347 
    DT.97855586  DT.95246365  DT.91766125  DT.95375871  DT.100823659  DT.121025796  DT.97855592  DT.100823657 
    DT.100823658  DT.120976880  DT.91640932  DT.97803186  DT.100823651  DT.100823662  DT.95375873 

    Selected AceView cDNA sequences (see all 476):

    CA433506 AA308975 BC064482 BM670206 AA588205 AA580350 AI500177 BM681745 
    CN480311 CR626166 CR619748 CK430963 CB854866 AA308974 BU733172 CA503148 
    AW001353 BM727532 AI656663 AB054538 AW026209 BQ639897 BQ420303 BM700467 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCTGTCTT
    WBP1 Expression
    About this image

    WBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516114

    UniProtKB/Swiss-Prot: WBP1_HUMAN, Q96G27
    Tissue specificity: Expressed in most tissues but at significantly lower levels in placenta, lung, liver, and
    kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for WBP1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wbp11 , 5 WW domain binding protein 11, 5 87.73(n)1
    84.76(a)1
      6 (35.94 cM)5
    223771  NM_001083922.11  NP_001077391.11 
     831190445 
    lizard
    (Anolis carolinensis)
    Reptilia WBP16
    WW domain binding protein 1
    35(a)
    1 ↔ 1
    GL344203.1(30373-39648)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.51332 Transcribed sequence with weak similarity to protein more 77.12(n)    BQ393819.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:773911 zgc:77391 61.3(n)
    55.17(a)
      402930  NM_205634.1  NP_991197.1 


    ENSEMBL Gene Tree for WBP1 (if available)
    TreeFam Gene Tree for WBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WBP1 gene
    WBP1L2  
    1 SIMAP similar gene for WBP1 using alignment to 4 protein entries:     WBP1_HUMAN (see all proteins):
    WBP1L

    Find genes that share paralogs with WBP1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for WBP1
    PGOHUM00000240128 PGOHUM00000240723


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for WBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv458185CNV Loss19166990
    nsv515851CNV Loss19592680
    dgv4166n71CNV Loss21882294
    dgv1199e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606961    OMIM disorders: --


    Find genes that share disorders with WBP1           About GenesLikeMe


    Export disorders for WBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WBP1 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with WBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. (PubMed id 15064722)1, 2 Ludes-Meyers J.H....Aldaz C.M. (Oncogene 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands. (PubMed id 9202023)1, 2 Chen H.I.... Sudol M. (J. Biol. Chem. 1997)
    5. Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PubMed id 9169421)1, 2 Pirozzi G.... Fowlkes D.M. (J. Biol. Chem. 1997)
    6. The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. (PubMed id 7644498)1, 3 Chen H.I. and Sudol M. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    7. Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1. (PubMed id 21841196)1 Morishima N....Nakano A. (J. Biol. Chem. 2011)
    8. Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors. (PubMed id 21981024)1 McDonald C.B....Farooq A. (Biochemistry 2011)
    9. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (Hum. Mol. Genet. 2011)
    10. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23559 HGNC: 12737 AceView: WBP1andHMGA1L4 Ensembl:ENSG00000239779 euGenes: HUgn23559
    ECgene: WBP1 H-InvDB: WBP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WBP1 gene:
    Search GeneIP for patents involving WBP1

    GeneCards and IP:
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