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WBP1 Gene

protein-coding GIFtS: 48
GCID: GC02P074685

WW Domain Binding Protein 1

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disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
WW Domain Binding Protein 1¹ ²
WBP-1² ³
WW Domain-Binding Protein 1²

External Ids:	HGNC: 12737¹	Entrez Gene: 23559²	Ensembl: ENSG00000239779⁷	OMIM: 606961⁵	UniProtKB: Q96G27³

Export aliases for WBP1 gene to outside databases

Previous GC identifers: GC02P074823 GC02P074643 GC02P074660 GC02P074597 GC02P074539 GC02P074421

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WBP1 Gene:

The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various

structural and regulatory proteins, is known to play a role in the mediation of protein-protein interactions.

This gene encodes a ligand of the WW domain of the Yes kinase-associated protein. Readthrough transcription of

the neighboring upstream gene, which encodes INO80 complex subunit B, into this gene generates a non-coding

transcript. (provided by RefSeq, Feb 2011)

GeneCards Summary for WBP1 Gene:

WBP1 (WW domain binding protein 1) is a protein-coding gene. GO annotations related to this gene include WW domain binding. An important paralog of this gene is WBP1L.

Gene Wiki entry for WBP1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000002.11 NC_018913.2 NT_022184.16

Regulatory elements:

Regulatory transcription factor binding sites in the WBP1 gene promoter:
HOXA9 ER-alpha GR p53 GCNF E47 GCNF-1 Hand1 GR-alpha GCNF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WBP1 promoter sequence

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Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WBP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12 Ensembl cytogenetic band: 2p13.1 HGNC cytogenetic band: 2p12

WBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WBP1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P074685: view genomic region (about GC identifiers)

Start:	74,685,456 bp from pter	End:	74,688,018 bp from pter
Size:	2,563 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
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About This Section

UniProtKB/Swiss-Prot: WBP1_HUMAN, Q96G27 (See protein sequence)

Recommended Name: WW domain-binding protein 1

Size: 269 amino acids; 29140 Da

Subunit: Interacts with NEDD4 (By similarity). Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with WWOX

Sequence caution: Sequence=AAD10950.1; Type=Erroneous initiation;

Secondary accessions: B2RE02 O95637

Explore the universe of human proteins at neXtProt for WBP1: NX_Q96G27

Explore proteomics data for WBP1 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See WBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_036609.1

ENSEMBL proteins:

ENSP00000233615 ENSP00000377542 ENSP00000386812 ENSP00000408816

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

1 InterPro protein domain:

IPR021684 Uncharacterised_WW-bd

Graphical View of Domain Structure for InterPro Entry Q96G27

ProtoNet protein and cluster: Q96G27

UniProtKB/Swiss-Prot: WBP1_HUMAN, Q96G27

Domain: The WW-binding 2 motif mediates interaction with WWOX. Both WW-binding motifs mediate interaction with

NEDD4 (By similarity)

Find genes that share domains with WBP1 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

Genatlas biochemistry entry for WBP1:

WW domain binding protein 1,proline-rich ligand of YES-associated,putatively involved in protein-protein

interaction

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15064722
GO:0050699	WW domain binding	ISS	--

Find genes that share ontologies with WBP1 About GenesLikeMe

Phenotypes:
2 GenomeRNAi human phenotypes for WBP1:

Increased G2M DNA content

S arrest

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	3
nucleus	3
plasma membrane	3
endoplasmic reticulum	1

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

Find genes that share ontologies with WBP1 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for WBP1 About

See pathways by source

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SuperPath

Contained pathways About

CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

Pathways by source See SuperPaths
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for WBP1

CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

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Interactions:

Search GeneGlobe Interaction Network for WBP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

Selected Interacting proteins for WBP1 (Q96G27^{1, 3} ENSP00000233615⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
WWP2	O00308³, ENSP00000348283⁴	I2D: score=2 STRING: ENSP00000348283
YAP1	P46937³, ENSP00000282441⁴	I2D: score=3 STRING: ENSP00000282441
NEDD4	P46934³, ENSP00000345530⁴	I2D: score=3 STRING: ENSP00000345530
MAGI1	Q96QZ7³, ENSP00000385450⁴	I2D: score=1 STRING: ENSP00000385450
WWP1	Q9H0M0³, ENSP00000265428⁴	I2D: score=2 STRING: ENSP00000265428

About this table

Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

Find genes that share ontologies with WBP1 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for WBP1 gene:

NM_012477.3

Unigene Cluster for WBP1:

WW domain binding protein 1

Hs.516114 [show with all ESTs]

Unigene Representative Sequence: BM811212

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000233615(uc002slj.2) ENST00000393972 ENST00000474185 ENST00000466835

ENST00000464774 ENST00000470536 ENST00000484744(uc002sll.2) ENST00000409737

ENST00000428943 ENST00000494741 ENST00000473467 ENST00000466303 ENST00000492047

ENST00000490120

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Additional mRNA sequence:

AF087888.1 AK315745.1 BC010012.2 BC064482.1 BC071626.1 BC071850.1

23 DOTS entries:

DT.448998 DT.102838859 DT.97855593 DT.100823652 DT.100761862 DT.86844063 DT.92329533 DT.121000347

DT.97855586 DT.95246365 DT.91766125 DT.95375871 DT.100823659 DT.121025796 DT.97855592 DT.100823657

DT.100823658 DT.120976880 DT.91640932 DT.97803186 DT.100823651 DT.100823662 DT.95375873

Selected AceView cDNA sequences (see all 476):

CA433506 AA308975 BC064482 BM670206 AA588205 AA580350 AI500177 BM681745

CN480311 CR626166 CR619748 CK430963 CB854866 AA308974 BU733172 CA503148

AW001353 BM727532 AI656663 AB054538 AW026209 BQ639897 BQ420303 BM700467

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WBP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGGCTGTCTT

About this image

WBP1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

WBP1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.516114

UniProtKB/Swiss-Prot: WBP1_HUMAN, Q96G27

Tissue specificity: Expressed in most tissues but at significantly lower levels in placenta, lung, liver, and

kidney

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for WBP1 gene from Selected species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Wbp1^{1 , 5}	WW domain binding protein 1^{1, 5}	87.73(n)¹ 84.76(a)¹		6 (35.94 cM)⁵ 22377¹ NM_001083922.1¹ NP_001077391.1¹ 83119044⁵
lizard (Anolis carolinensis)	Reptilia	WBP1⁶	WW domain binding protein 1	35(a)	1 ↔ 1	GL344203.1(30373-39648)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.5133²	Transcribed sequence with weak similarity to protein more	77.12(n)		BQ393819.1
zebrafish (Danio rerio)	Actinopterygii	zgc:77391¹	zgc:77391	61.3(n) 55.17(a)		402930 NM_205634.1 NP_991197.1

ENSEMBL Gene Tree for WBP1 (if available)
TreeFam Gene Tree for WBP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for WBP1 gene

WBP1L²

1 SIMAP similar gene for WBP1 using alignment to 4 protein entries: WBP1_HUMAN (see all proteins):

WBP1L

Find genes that share paralogs with WBP1 About GenesLikeMe

2 Pseudogenes.org Pseudogenes for WBP1
PGOHUM00000240128 PGOHUM00000240723

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Structural Variations
Database of Genomic Variants (DGV) 4 variations for WBP1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv458185	CNV	Loss	19166990
nsv515851	CNV	Loss	19592680
dgv4166n71	CNV	Loss	21882294
dgv1199e1	CNV	Complex	17122850

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About This Section

OMIM gene information: 606961 OMIM disorders: --

Find genes that share disorders with WBP1 About GenesLikeMe

Export disorders for WBP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for WBP1 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with WBP1)

WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. (PubMed id 15064722)^{1, 2} Ludes-Meyers J.H....Aldaz C.M. (Oncogene 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands. (PubMed id 9202023)^{1, 2} Chen H.I.... Sudol M. (J. Biol. Chem. 1997)
Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PubMed id 9169421)^{1, 2} Pirozzi G.... Fowlkes D.M. (J. Biol. Chem. 1997)
The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. (PubMed id 7644498)^{1, 3} Chen H.I. and Sudol M. (Proc. Natl. Acad. Sci. U.S.A. 1995)
Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1. (PubMed id 21841196)¹ Morishima N....Nakano A. (J. Biol. Chem. 2011)
Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors. (PubMed id 21981024)¹ McDonald C.B....Farooq A. (Biochemistry 2011)
Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PubMed id 21078624)¹ Kahle J.J....Zoghbi H.Y. (Hum. Mol. Genet. 2011)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)¹ Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23559	HGNC: 12737	AceView: WBP1andHMGA1L4	Ensembl:ENSG00000239779	euGenes: HUgn23559
ECgene: WBP1	H-InvDB: WBP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for WBP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for WBP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for WBP1 gene:
Search GeneIP for patents involving WBP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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WBP1 Gene

WW Domain Binding Protein 1

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WBP1 Gene

WW Domain Binding Protein 1

Aliasesfor WBP1 gene

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WBP1 Human Recombinant Protein Products:

WBP1 Antibody Products:

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