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WBP1 Gene

protein-coding   GIFtS: 49

GC02P074539
WW domain binding protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
MGC15305 2
WBP-1 1, 2, 3
Descriptions
WW domain binding protein 1 2
External Ids
HGNC: 127371
Entrez Gene: 235592
UniProtKB: Q96G273
Ensembl: ENSG000001152747
Search outside databases for aliases for WBP1 gene

Previous GC identifers: GC02P074823 GC02P074643 GC02P074660 GC02P074597

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for WBP1:
The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of
diverse functions including structural, regulatory, and signaling proteins. The domain is involved
in mediating protein-protein interactions through the binding of polyproline ligands. This gene
encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein
by a conserved region: XPPXY motif. The function of this protein has not been determined.
[provided by RefSeq]

Gene Wiki entry for WBP1
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WBP1 gene  

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p12

WBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P074539:     (about GC identifiers)

Start:
74,539,035 bp from pter
End:
74,541,526 bp from pter
Size:
2,492 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000002.10  NT_022184.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: WBP1_HUMAN, Q96G27 (See protein sequence)
Recommended Name: WW domain-binding protein 1  
Size: 269 amino acids; 29140 Da
Subunit: Interacts with NEDD4 (By similarity). Binds to the WW domain of YAP1, WWP1 and WWP2.
Interacts with WWOX
Secondary accessions: O95637

REFSEQ proteins: NP_036609.1  

ENSEMBL proteins: 
ENSP00000377542 ENSP00000386812 ENSP00000233615 


Human Recombinant Proteins 
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Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (WBP1)
Human Recombinant Proteins from Abnova (WBP1)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016021 integral to membrane ISS--
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Antibodies for WBP1: 
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Antibodies from Abcam (WBP1), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (WBP1)
Novus Biologicals Antibodies for WBP1

Assays for WBP1: 
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Browse Kits and Assays available from Millipore
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Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q96G27

UniProtKB/Swiss-Prot: WBP1_HUMAN, Q96G27
Domain: The WW-binding 2 motif mediates interaction with WWOX. Both WW-binding motifs mediate
interaction with NEDD4 (By similarity)

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (WBP1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (WBP1)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012477

              Applied Biosystems Silencer® siRNAs for WBP1

              Sigma-Aldrich siRNA for WBP1  
                     Sigma-Aldrich shRNA for WBP1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for WBP1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012477
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_012477
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_012477 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_012477

Genatlas biochemistry entry for WBP1:
WW domain binding protein 1,proline-rich ligand of YES-associated,putatively involved in
protein-protein interaction

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005515 protein binding NAS7644498
GO:0050699 WW domain binding ISS--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



4 Interacting proteins for WBP1 (ENSP000002336153) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
WBP2ENSP000002548063STRING (score=.95)
ABCC11ENSP000003490173STRING (score=.879)
YAP1ENSP000002824413STRING (score=.873)
NEDD4ENSP000003455303STRING (score=.831)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008150 biological_process ND--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WBP1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (WBP1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (WBP1)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012477

              Sigma-Aldrich siRNA for WBP1  
                     Sigma-Aldrich shRNA for WBP1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_012477  

REFSEQ mRNAs for WBP1 gene: 

NM_012477.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_012477  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012477
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_012477
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_012477 

Additional cDNA sequence: 

AF087888.1 AK315745.1 BC010012.2 BC064482.1 BC071626.1 BC071850.1 CR607952.1 CR618691.1 
CR619748.1 CR626166.1 

23 DOTS entries:

DT.448998  DT.102838859  DT.97855593  DT.100823652  DT.100761862  DT.86844063  DT.92329533  DT.121000347 
DT.97855586  DT.95246365  DT.91766125  DT.95375871  DT.100823659  DT.121025796  DT.97855592  DT.100823657 
DT.100823658  DT.120976880  DT.91640932  DT.97803186  DT.100823651  DT.100823662  DT.95375873 

24/476 AceView cDNA sequences (see all 476 ):

W05329 CR618691 AW026209 BX397181 CK430963 CB854866 BC010012 BQ574774 
CR626166 BM672983 CR619748 CD675378 AW001353 BG757152 BC039617 BC064425 
AI918863 AI871034 AI291350 AI299347 AA308975 NM_031288 BU733172 AI382209 

highest scoring ESTs for WBP1:

AA887990 AA039492 AA041546 AA083263 AA224332 AA308974 AA308975 AA362297 AA375056 AA393844 

Unigene Cluster for WBP1:

WW domain binding protein 1
Hs.516114  [show with all ESTs]
Unigene Representative Sequence: BM811212


GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:
ENST00000393972  ENST00000409737  ENST00000233615  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WBP1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for WBP1

1 / 2 / 3

3 probe-sets matching WBP1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

57225_at2, 3 U95-B 3 0.88 0.58 1.00 1.00 AA887990 1.00 0.90 0.95 1

223072_s_at2, 3 U133-B 3 1.00 0.47 -- -- U79457 0.60 0.83 0.73 1

223072_s_at2 U133Plus2 3 1.00 0.47 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GGGCTGTCTT

SOURCE GeneReport for Unigene cluster: Hs.516114

UniProtKB/Swiss-Prot: WBP1_HUMAN, Q96G27
Tissue specificity: Expressed in most tissues but at significantly lower levels in placenta, lung,
liver, and kidney

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for WBP1 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
WBP11   -- WW domain binding protein 1 89.14(n)
87.27(a)
475787  XM_847547.1  XP_852640.1 
chimpanzee
(Pan troglodytes)
WBP11   -- WW domain binding protein 1 98.51(n)
97.77(a)
740417  XM_001158989.1  XP_001158989.1 
cow
(Bos taurus)
WBP11   -- WW domain binding protein 1 88.72(n)
85.87(a)
509188  NM_001034346.1  NP_001029518.1 
rat
(Rattus norvegicus)
Wbp11   -- WW domain binding protein 1 87.24(n)
84.39(a)
297381  XM_216198.4  XP_216198.3 
mouse
(Mus musculus)
Wbp11, 5 65
WW domain binding protein 11, 5 87.73(n)1
84.76(a)1
223771  NM_016757.21  NP_058037.21 
 AF0017975  AI2551525  (see all 27)
About this table        Species with no ortholog for WBP1

ENSEMBL Gene Tree for WBP1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for WBP1 gene
C10orf262  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


9 NCBI SNPs in WBP1 are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 2 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs84691,2
A,C,F74541058(+) CCCCCT/CCATCA 1 P/P syn11Minor allele frequency- C:0.15MN 184
rs22700161,2
A,C,F,H74539837(-) CCTGCA/GCGGTT 1 -- int15Minor allele frequency- G:0.18EA EU WA 1878
--
rs74200931,2
--74540554(+) TGTTGC/GGCCTT 1 C/W mis10--------
rs10512831,2
--74541912(-) ACTACT/AGAAGG 1 -- ng311Minor allele frequency- A:0.00MN 184
--
rs617357501,2
--74541059(+) CCCCTA/CATCAG 1 H/N mis10--------
--
rs561186751,2
--74540573(+) GACGAG/TCTAAA 1 A/S mis10--------
--
rs617357531,2
--74541089(+) GGGTGA/TCCCCT 1 T/S mis10--------
--
rs729072061,2
--74540857(+) GCAGGC/TTTCCT 1 R/R syn10--------
--
rs714068731,2
--74539979(+) GGGTT-/GGGGGA 1 -- int10--------
About this table
The following additional 22 SNP(s) have been found in Applied Biosystems data source:
(Click for Applied Biosystems TaqMan ® Genotyping Assay)


 rs9658 rs6746854 rs1063589 rs11735 rs1054223 rs7586128 rs3179878
 rs3213671 rs1063587 rs2268417 rs61733470 rs34174194 rs1054226 rs2284708
 rs7562663 rs34075781 rs3191651 rs1063588 rs35533773 rs1054209 rs34838944
 rs4686

HapMap Linkage Disequilibrium images for WBP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606961

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

9 PubMed articles for WBP1 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23559 HGNC: 12737 AceView: WBP1andHMGA1L4 Ensembl:ENSG00000115274 euGenes: HUgn23559
ECgene: WBP1 H-InvDB: WBP1
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for WBP1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Antibodies for WBP1

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