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WASL Gene

protein-coding GIFtS: 62

GC07M123109

Wiskott-Aldrich syndrome-like
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CR16 ^⁵
DKFZp779G0847 ^²
MGC48327 ^²
N-WASP ^¹, ², ³
NWASP ^¹, ²
WIPF3 ^⁵

Descriptions
Wiskott-Aldrich syndrome gene-like ^²
Wiskott-Aldrich syndrome gene-like protein ^²
Wiskott-Aldrich syndrome-like ^²
neural Wiskott-Aldrich syndrome protein ^²

External Ids
HGNC: 12735¹
Entrez Gene: 8976²
UniProtKB: O00401³
Ensembl: ENSG00000106299⁷

Search outside databases for aliases for WASL gene

Previous GC identifers: GC07M121799 GC07M122862 GC07M122876 GC07M122915

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for WASL:

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are

involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton.

The presence of a number of different motifs suggests that they are regulated by a number of

different stimuli, and interact with multiple proteins. Recent studies have demonstrated that

these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate

formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene

product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and

shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce

formation of long actin microspikes. [provided by RefSeq]

UniProtKB/Swiss-Prot: WASL_HUMAN, O00401

Function: Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3

complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that

negatively regulates HSP90 expression

Gene Wiki entry for WASL

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the WASL gene

Entrez Gene cytogenetic band: 7q31.3 Ensembl cytogenetic band: 7q31.32 HGNC cytogenetic band: 7q31.3

WASL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M123109: (about GC identifiers)

Start:	123,109,233 bp from pter
End:	123,176,352 bp from pter
Size:	67,120 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 122,710,624-122,777,740

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: WASL_HUMAN, O00401 (See protein sequence)

Recommended Name: Neural Wiskott-Aldrich syndrome protein

Size: 505 amino acids; 54827 Da

Subunit: Binds actin and the Arp2/3 complex. Interacts with CDC42. Binds to SH3 domains of GRB2.

Interacts with the C-terminal SH3 domain of DNMBP. Interacts with the WW domains of PRPF40A/FBP11

(By similarity). Interacts with NOSTRIN. Interacts with Shigella flexneri protein icsA. The

interaction with icsA enhances the affinity of WASL for Arp2/3, thus assembling a tight complex

which has maximal activity in actin assembly

Subcellular location: Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity).

Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when

unphosphorylated (By similarity)

PDB structure from and Proteopedia :

2FF3 (3D)

2VCP (3D)

Secondary accessions: Q7Z746

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003932.3

ENSEMBL proteins:

ENSP00000223023

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (N WASP)
	Human Recombinant Proteins from Abnova (WASL)

OriGene Purified Recombinant Human Protein: WASL

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005730	nucleolus	IDA	18029348
GO:0005737	cytoplasm	IEA	--
GO:0015629	actin cytoskeleton	TAS	9422512
GO:0030027	lamellipodium	IEA	--

About this table

Antibodies for WASL:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of WASL
	Sigma-Aldrich Antibodies for WASL
	R&D Systems Antibodies for WASL (N-WASP)
	Cell Signaling Technology (CST) Antibodies for WASL (N-WASP)
	Antibodies from Abcam (N WASP), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (WASL)
	Novus Biologicals Antibodies for WASL

Assays for WASL:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O00401

ProtoNet protein and cluster: O00401

1 Blocks protein family: IPB003124 Actin-binding WH2

UniProtKB/Swiss-Prot: WASL_HUMAN, O00401

Similarity: Contains 1 CRIB domain

Similarity: Contains 1 WH1 domain

Similarity: Contains 2 WH2 domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WASL)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (WASL)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003941

Applied Biosystems Silencer® siRNAs for WASL

Sigma-Aldrich siRNA for WASL

Sigma-Aldrich shRNA Panels and shRNA for WASL

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for WASL
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003941
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003941
untagged cDNA clone in CMV expression vector: NM_003941

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003941

UniProtKB/Swiss-Prot: WASL_HUMAN, O00401

Function: Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3

complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that

negatively regulates HSP90 expression

Genatlas biochemistry entry for WASL:

Wiskott-Aldrich syndrome protein-like,64kDa,neural,concentrated at the nerve terminal

region,inducing long actin microspikes when coexpressed with active CDC42

11 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Wasl):

	cellular	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	hematopoietic system	immune system	lethality-prenatal/perinatal	nervous system
normal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005083	small GTPase regulator activity	TAS	9422512
GO:0005515	protein binding	IPI	14732713 16253999 16293614 17474147

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for WASL (Your Favorite Gene powered by Ingenuity) (see all 8 )

Axonal Guidance Signaling
Integrin Signaling
Germ Cell-Sertoli Cell Junction Signaling
Actin Cytoskeleton Signaling
Clathrin-mediated Endocytosis

GeneDecks WASL for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for WASL

5/78 Interacting proteins for WASL (O00401^{1, 2} ENSP00000223023³) via UniProtKB, MINT, and/or STRING (see all 78 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITSN1	Q15811², ENSP00000370719³	MINT-14607 MINT-14605 MINT-14606 MINT-14608 STRING (score=.982)
CRK	P46108², ENSP00000300574³	MINT-72620 MINT-72571 STRING (score=.851)
CDC42P2	P60953², ENSP00000314458³	MINT-72703 STRING (score=.999)
NCK1	P16333¹, ENSP00000288986³	EBI-957615, EBI-389883 STRING (score=.999)
WIPF1	O43516², ENSP00000272746³	MINT-2748661 STRING (score=.999)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006461	protein complex assembly	TAS	9422512
GO:0006928	cell motion	TAS	9422512
GO:0008154	actin polymerization or depolymerization	TAS	9422512

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WASL
10 Novoseek chemical compound relationships for WASL gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
wiskostatin	95.26	12	17405146 (2), 15235593 (2), 18667055 (2), 15800060 (1) (see all 7)
pip2	61.97	8	8895577 (2), 12147689 (2), 11792818 (1), 17302440 (1) (see all 6)
tyrosine	31.85	19	12431372 (4), 8895577 (2), 17474908 (2), 14676198 (2) (see all 10)
proline	25.22	3	17229736 (1), 12147689 (1), 10973991 (1)
phosphoinositide	24.80	4	16949824 (1), 10953003 (1), 11865026 (1)
phosphatidylinositol	12.78	5	11694514 (2), 11052943 (1), 18923421 (1), 10219243 (1)
glucose	4.05	2	11694514 (1), 12456725 (1)
lipid	0.00	5	17988218 (2), 12477732 (2), 17302440 (1)
latex	0.00	2	11401525 (1), 12551957 (1)
adp	0.00	3	11792818 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WASL)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (WASL)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003941

Sigma-Aldrich siRNA for WASL

Sigma-Aldrich shRNA Panels and shRNA for WASL

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003941

REFSEQ mRNAs for WASL gene:

NM_003941.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003941

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003941
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003941
                                 untagged cDNA clone in CMV expression vector: NM_003941

Additional cDNA sequence:

AK131016.1 BX640852.1 CR591885.1

10 DOTS entries:

DT.218480 DT.75117246 DT.95268724 DT.121053298 DT.65287633 DT.121053301 DT.121053311 DT.75118576

DT.92421825 DT.100701098

24/159 AceView cDNA sequences (see all 159 ):

CB127157 W73531 BE891172 BQ717939 CN484199 AI969375 BU952498 AI521769

BU951055 AI653277 BQ286524 CD107134 CB132489 CD359638 AI620950 BQ425087

BE504979 AW044456 BM751087 N34978 AI352141 BU902219 CB123879 BQ269867

highest scoring ESTs for WASL:

D88460 AA448782 AA625268 AA860954 AI261600 AI459169 AI478180 AI478447 AI742750 AI760111

Unigene Clusters for WASL:

Wiskott-Aldrich syndrome-like

Hs.143728 [show with all ESTs], Hs.708402 [show with all ESTs]

Unigene Representative Sequences: NM_003941, BX640852

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000223023

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WASL expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for WASL

¹ / ² / ³

9 probe-sets matching WASL gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39875_at²^{, 3}	U95-A	1	1.00	1.00	0.56	0.16	D88460	1.00	1.00	1.00	1
321_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.38	D88460	1.00	1.00	1.00	1
44736_at²^{, 3}	U95-B	2	1.00	0.97	0.81	1.68	W92114	0.40	1.00	0.76	1
224813_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL523820	0.40	1.00	0.76	1
205810_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003941	0.60	1.00	0.82	1
205809_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE504979	0.80	1.00	0.91	1
224813_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205810_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205809_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks WASL for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.143728 Hs.708402
Expression variation in blood from EXPOLDB for WASL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WASL gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WASL¹	--	Wiskott-Aldrich syndrome-like	92.67(n) 97.03(a)	475213 XM_854177.1 XP_859270.1
chimpanzee (Pan troglodytes)	WASL¹	--	Wiskott-Aldrich syndrome-like	99.67(n) 100(a)	463688 XM_519342.2 XP_519342.2
cow (Bos taurus)	WASL¹	--	Wiskott-Aldrich syndrome-like	93.86(n) 96.04(a)	281577 NM_174219.2 NP_776644.1
mouse (Mus musculus)	Wasl^{1, 5}	6⁵	Wiskott-Aldrich syndrome-like (human)^{1, 5}	90.62(n)¹ 96.01(a)¹	73178¹ NM_028459.1¹ NP_082735.1¹ AI326829⁵ AJ318416⁵ (see all 17)
chicken (Gallus gallus)	WASL¹	--	Wiskott-Aldrich syndrome-like	82.94(n) 91.47(a)	417750 XM_415994.2 XP_415994.2

About this table Species with no ortholog for WASL

ENSEMBL Gene Tree for WASL

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for WASL gene

WAS²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/374 NCBI SNPs in WASL are shown (see all 374 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 147)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs767637^1,2	A,C,F,H	123109214(-)	`TTCATT/GTGTTT`	1	--	ng5¹		5		NA EU EA WA	460
	rs1506642^1,2	A,C,F,H	123177294(-)	`TGTTAT/CAGACG`	1	--	ng3¹		4		EU EA WA	410
	rs1058168^1,2	C,F,H	123110487(-)	`ATTTAA/CATACA`	1	--	ut3¹		8		MN EU EA WA NA	704
	rs17695264^1,2	C,F,H	123110015(+)	`CTCCTG/CATTTT`	1	--	ut3¹ ese³		11		NA EU EA WA	980
	rs3735435^1,2	C,F,H	123176995(-)	`GCAGGC/TGGTGG`	1	--	ng3¹		7		EA MN EU WA	3152
--	rs13044^1,2	A,C	123109952(+)	`AAAAAA/TTTTTT`	1	--	ut3¹		0	--	--	--	--
	rs4731119^1,2	A,F	123176329(+)	`CCGCAG/CCGGCG`	1	--	ut5¹ ese³		2		MN EA	1252
	rs1073682^1,2	H	123110320(+)	`AAATTC/GAAGCC`	1	--	ut3¹ ese³		5		MN EU EA WA	604
	rs3802009^1,2	C	123110664(-)	`TTTTTA/TAAGAT`	1	--	ut3¹ ese³		0	--	--	--	--
	rs1506641^1,2	A	123177379(-)	`GTTTAC/TCAGTC`	1	--	ng3¹ tfbs³		0	--	--	--	--

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HapMap Linkage Disequilibrium images for WASL (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 612432

9 Novoseek disease relationships for WASL gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
wiskott-aldrich syndrome	95.50	66	11952639 (2), 15085951 (2), 17092940 (2), 11432863 (2) (see all 54)
scar1	87.03	8	11747816 (6), 14561714 (1), 11029465 (1)
scar	40.05	6	12872157 (1), 10940259 (1), 11747836 (1), 15362118 (1) (see all 6)
cancer	1.98	1	17985201 (1)
shock	0.00	4	12871950 (2), 15791211 (1), 17535252 (1)
cystic fibrosis	0.00	1	17306384 (1)
carcinoma	0.00	7	15084285 (2), 15362118 (1), 18362183 (1)
tumors	0.00	5	17092940 (3), 15699051 (1)
metastasis	0.00	1	17985201 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/185 PubMed articles for WASL gene (see all 185 ):

Identification of N-WASP homologs in human and rat brain. (PubMed id 9322739)^{1, 2, 3, 4} Fukuoka M....Takenawa T. (1997)
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. (PubMed id 9422512)^{1, 2, 3} Miki H....Takenawa T. (1998)
The structural basis of actin interaction with multiple WH2/beta- thymosin motif-containing proteins. (PubMed id 16531231)^{1, 3, 4} Aguda A.H.... Robinson R.C. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{3, 4} Hillier L.W.... Wilson R.K. (2003)
Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility. (PubMed id 10491394)^{3, 4} Egile C.... Carlier M.-F. (1999)
Neural Wiskott-Aldrich syndrome protein is implicated in the actin- based motility of Shigella flexneri. (PubMed id 9582270)^{3, 4} Suzuki T.... Sasakawa C. (1998)
Translocation of N-WASP by nuclear localization and export signals into the nucleus modulates expression of HSP90. (PubMed id 12871950)^{1, 3} Suetsugu S. and Takenawa T. (2003)
Interaction of HSP90 to N-WASP leads to activation and protection from proteasome-dependent degradation. (PubMed id 15791211)^{1, 3} Park S.J....Takenawa T. (2005)
N-WASP is a putative tumour suppressor in breast cancer cells, in vitro and in vivo, and is associated with clinical outcome in patients with breast cancer. (PubMed id 17985201)^{1, 3} Martin T.A....Jiang W.G. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 8976	HGNC: 12735	AceView: WASL	Ensembl:ENSG00000106299	euGenes: HUgn8976
ECgene: WASL	H-InvDB: WASL

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for WASL	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for WASL
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for WASL:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for WASL-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for WASL		Antibodies for WASL
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for WASL		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (WASL)
	Antibodies (WASL)
	Chimera RNAi (WASL)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for WASL (N-WASP)

	Recombinant Proteins (N WASP)
	Antibodies (N WASP)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Antibodies for WASL

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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WASL Gene at Home site.
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WASL Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for WASL

Summaries
for WASL

Genomic Location
for WASL

Proteins
for WASL

Protein Domains/
Families
for WASL

Gene Function
for WASL

Pathways & Interactions
for WASL

Drugs & Compounds
for WASL

Transcripts
for WASL

Expression
for WASL

Orthologs
for WASL

Paralogs
for WASL

SNPs/Variants
for WASL

Disorders & Mutations
for WASL

Medical News
for WASL

Publications
for WASL

Search for WASL

Genome Databases showing WASL

Other Databases showing WASL

Specialized Databases showing WASL

Licensable Technologies
for WASL

Services
for WASL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WASL Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor WASL

Summariesfor WASL

Genomic Locationfor WASL

Proteinsfor WASL

Protein Domains/Familiesfor WASL

Gene Functionfor WASL

Pathways & Interactionsfor WASL

Drugs & Compoundsfor WASL

Transcriptsfor WASL

Expression for WASL

Orthologsfor WASL

Paralogsfor WASL

SNPs/Variantsfor WASL

Disorders & Mutationsfor WASL

Medical Newsfor WASL

Publicationsfor WASL

Search for WASL

Genome Databases showing WASL

Other Databases showing WASL

Specialized Databases showing WASL

Licensable Technologiesfor WASL

Servicesfor WASL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for WASL

Summaries
for WASL

Genomic Location
for WASL

Proteins
for WASL

Protein Domains/
Families
for WASL

Gene Function
for WASL

Pathways & Interactions
for WASL

Drugs & Compounds
for WASL

Transcripts
for WASL

Expression
for WASL

Orthologs
for WASL

Paralogs
for WASL

SNPs/Variants
for WASL

Disorders & Mutations
for WASL

Medical News
for WASL

Publications
for WASL

Licensable Technologies
for WASL

Services
for WASL