Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WASL Gene

protein-coding   GIFtS: 62
GCID: GC07M123321

Wiskott-Aldrich syndrome-like
 Explore 16 diseases affiliated with
WASL via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WASL    

Aliases
for WASL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Wiskott-Aldrich Syndrome-Like1 2
N-WASP1 2 3
NWASP1 2
Neural Wiskott-Aldrich Syndrome Protein2
Wiskott-Aldrich Syndrome Gene-Like2

External Ids:    HGNC: 127351   Entrez Gene: 89762   Ensembl: ENSG000001062997   OMIM: 6050565   UniProtKB: O004013   

Export aliases for WASL gene to outside databases

Previous GC identifers: GC07M121799 GC07M122862 GC07M122876 GC07M122915 GC07M123109 GC07M117685


Summaries
for WASL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WASL:
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction
of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs
suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies
have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to
regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a
homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in
neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WASL_HUMAN, O00401
Function: Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Binds to
HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression

summary for WASL:
Neural Wiskott-Aldrich syndrome protein (N-WASP) is a member of the Wiskott-Aldrich syndrome-like (WASL)
protein family. It is ubiquitously expressed and regulates actin polymerization by activating the Arp2/3
complex.

Gene Wiki entry for WASL


Genomic Views
for WASL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WASL gene promoter:
         Nkx3-1   Elk-1   AML1a   Nkx3-1 v1   AP-4   C/EBPalpha   GATA-1   RORalpha1   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): WASL promoter sequence
   Search SABiosciences Chromatin IP Primers for WASL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WASL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.3   Ensembl cytogenetic band:  7q31.32   HGNC cytogenetic band: 7q31.3

WASL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WASL gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M123321:  view genomic region     (about GC identifiers)

Start:
 123,321,989 bp from pter      End:
 123,389,121 bp from pter
Size:
 67,133 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 122,710,624-122,777,740     

Proteins
for WASL gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WASL_HUMAN, O00401 (See protein sequence)
Recommended Name: Neural Wiskott-Aldrich syndrome protein  
Size: 505 amino acids; 54827 Da
Subunit: Binds actin and the Arp2/3 complex. Interacts with CDC42. Binds to SH3 domains of GRB2. Interacts with the
C-terminal SH3 domain of DNMBP. Interacts with SNX9. Interacts with the WW domains of PRPF40A/FBP11. Interacts with
PTK2/FAK1 (By similarity). Interacts with NOSTRIN. Interacts with Shigella flexneri protein IcsA. The interaction with
IcsA enhances the affinity of WASL for Arp2/3, thus assembling a tight complex which has maximal activity in actin
assembly. Interacts with E.coli effector protein EspF(U). Identified in a complex containing at least WASL, BAIAP2L1
and E.coli EspF(U). Binds to TNK2
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Note=Preferentially localized
in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity)
3 PDB 3D structures from and Proteopedia for WASL:
2FF3 (3D)        2LNH (3D)        2VCP (3D)    
Secondary accessions: Q7Z746

Explore the universe of human proteins at neXtProt for WASL: NX_O00401

Post-translational modifications:

  • Phosphorylation at Ser-242, Tyr-256, Ser-484 and Ser-485 enhances actin polymerization activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00401

    • WASL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003932.3  
    ENSEMBL proteins: 
     ENSP00000223023   ENSP00000417672  
    Reactome Protein details: O00401
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: WASL
    OriGene Protein Over-expression Lysate: WASL
    OriGene Custom Protein Services for WASL 
    GenScript Custom Purified and Recombinant Proteins Services for WASL
    Novus Biologicals WASL Proteins
    Novus Biologicals WASL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for WASL

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane ----
    GO:0005634nucleus IEA--
    GO:0005730nucleolus ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--


    WASL for ontologies           About GeneDecksing



    WASL Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of WASL
    R&D Systems Antibodies for WASL (N-WASP)
    Cell Signaling Technology (CST) Antibodies for WASL  (N-WASP)
    OriGene Antibodies: WASL
    OriGene Custom Antibody Services for WASL 
    GenScript Custom Superior Antibodies Services for WASL
    Novus Biologicals WASL Antibodies
    Abcam antibodies for WASL 
    Uscn Antibodies for WASL
    ThermoFisher Antibodies for WASL

    Assay Products for WASL: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WASL
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for WASL

    Protein Domains /
    Families
    for WASL gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WASL for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR003124 WH2_dom
     IPR000095 PAK_box_Rho-bd
     IPR011993 PH_like_dom
     IPR000697 EVH1
     IPR011026 WASP_C

    Graphical View of Domain Structure for InterPro Entry O00401

    ProtoNet protein and cluster: O00401

    1 Blocks protein family: IPB003124 Actin-binding WH2

    UniProtKB/Swiss-Prot: WASL_HUMAN, O00401
    Similarity: Contains 1 CRIB domain
    Similarity: Contains 1 WH1 domain
    Similarity: Contains 2 WH2 domains


    Function
    for WASL gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: WASL_HUMAN, O00401
    Function: Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Binds to
    HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression

         Genatlas biochemistry entry for WASL:
    Wiskott-Aldrich syndrome protein-like,64kDa,neural,concentrated at the nerve terminal region,inducing long actin
    microspikes when coexpressed with active CDC42

    miRNA
    Products:            		 OriGene 3'-UTR Clone: WASL
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WASL
    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate WASL (see all 74):
    hsa-miR-520f hsa-miR-3146 hsa-miR-15a hsa-miR-374a hsa-miR-3613-3p hsa-miR-3116 hsa-miR-130b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: WASL 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WASL (see all 7)
    OriGene shRNA RFP: WASL
    OriGene siRNA: WASL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WASL

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for WASL

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WASL (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WASL
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: WASL (NM_003941)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WASL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WASL 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for WASL
    Search LifeMap BioReagents cell lines for WASL

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASL

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005083small GTPase regulator activity IEA--
    GO:0005515protein binding IPI--


    WASL for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for WASL: Wasltm1.1Sbs Wasltm1.1Cgn Wasltm1Sbs
         11 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Wasl):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  immune system  mortality/aging  nervous system 
     normal 

    WASL for phenotypes           About GeneDecksing


    Pathways & Interactions
    for WASL gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/36 super-pathways (see all 36) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of actin dynamics for phagocytic cup formation
    		Regulation of actin dynamics for phagocytic cup formation1.00
    		Fcgamma receptor (FCGR) dependent phagocytosis0.80
    		Role of myosins in phagosome formation0.80
    		Branching and elongation of mother and daughter filaments0.29
    2Metabolism of nitric oxide
    		Metabolism of nitric oxide1.00
    		NOSTRIN mediated translocation of eNOS from plasma membrane0.29
    		eNOS activation and regulation1.00
    		NOSTRIN mediated eNOS trafficking0.29
    3Cytoskeleton remodeling Slit-Robo signaling
    		Cytoskeleton remodeling Slit-Robo signaling1.00
    		Cell adhesion_Cadherin-mediated cell adhesion0.28
    		Development_Slit-Robo signaling0.92
    		Cell adhesion Cadherin-mediated cell adhesion0.28
    4Cell adhesion_Integrin-mediated cell adhesion and migration
    		Cell adhesion_Integrin-mediated cell adhesion and migration1.00
    		Cytoskeleton remodeling Fibronectin-binding integrins in cell motility0.32
    		Cell adhesion Integrin-mediated cell adhesion and migration1.00
    		Cytoskeleton remodeling_Fibronectin-binding integrins in cell motility0.32
    5G-protein signaling_RAC1 in cellular process
    		Cytoskeleton remodeling_CDC42 in cellular processes0.37
    		CDC42 signaling events0.17
    		Cytoskeleton remodeling CDC42 in cellular processes0.37

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/7 EMD Millipore Pathways for WASL (see all 7)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling CDC42 in cellular processes
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Cytoskeleton remodeling Slit-Robo signaling

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WASL (see all 9)
        Actin-Based Motility by Rho Family GTPases
    Guidance Cues and Growth Cone Motility
    CDC42 Pathway
    PDGF Pathway
    Signaling by Slit

    1 Cell Signaling Technology (CST) Pathway for WASL
        Cytoskeletal Signaling

    5/7 GeneGo (Thomson Reuters) Pathways for WASL (see all 7)
        Cytoskeleton remodeling Role of PDGFs in cell migration
    Cell adhesion Integrin-mediated cell adhesion and migration
    Development Slit-Robo signaling
    Cytoskeleton remodeling CDC42 in cellular processes
    Cytoskeleton remodeling Reverse signaling by ephrin B

    5/10 BioSystems Pathways for WASL (see all 10) 
        EGFR1 Signaling Pathway
    G13 Signaling Pathway
    Pathogenic Escherichia coli infection
    Signaling events mediated by focal adhesion kinase
    ErbB1 downstream signaling

    5/17        Reactome Pathways for WASL (see all 17)
        Nephrin interactions
    Developmental Biology
    Role of myosins in phagosome formation
    Branching and elongation of mother and daughter filaments
    Metabolism


    5/7         Kegg Pathways  (Kegg details for WASL) (see all 7):
        Chemokine signaling pathway
    Adherens junction
    Fc gamma R-mediated phagocytosis
    Regulation of actin cytoskeleton
    Bacterial invasion of epithelial cells


    WASL for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WASL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/95 Interacting proteins for WASL (O004011, 2, 3 ENSP000002230234) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITSN1Q158112, 3, ENSP000003707194MINT-14607 MINT-14605 MINT-14606 MINT-7302543 MINT-14608 I2D: score=3 STRING: ENSP00000370719
    CRKP461082, 3, ENSP000003005744MINT-72620 MINT-72571 I2D: score=1 STRING: ENSP00000300574
    SNX9Q9Y5X12, 3, ENSP000003760244MINT-7302014 MINT-7302027 I2D: score=1 STRING: ENSP00000376024
    GRB2P629931, 3, ENSP000003390074EBI-957615,EBI-401755 I2D: score=5 STRING: ENSP00000339007
    CTTNQ142472, 3, ENSP000003018434MINT-6541916 I2D: score=3 STRING: ENSP00000301843
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006461protein complex assembly IEA--
    GO:0006900membrane budding ISS--
    GO:0006928cellular component movement TAS9422512


    WASL for ontologies           About GeneDecksing



    Drugs & Compounds
    for WASL gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    WASL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for WASL available from Tocris Bioscience    About this table
    CompoundAction CAS #
    WiskostatinN-WASP inhibitor; inhibits Arp2/3 activation[253449-04-6]
    10/11 Novoseek chemical compound relationships for WASL gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskostatin 95.1 13 17405146 (2), 15235593 (2), 18667055 (2), 15800060 (1) (see all 8)
    pip2 60.7 8 8895577 (2), 12147689 (2), 11792818 (1), 17302440 (1) (see all 6)
    tyrosine 36.2 19 12431372 (4), 8895577 (2), 17474908 (2), 14676198 (2) (see all 10)
    proline 22.9 3 17229736 (1), 12147689 (1), 10973991 (1)
    phosphoinositide 22.4 4 16949824 (1), 10953003 (1), 11865026 (1)
    phosphatidylinositol 10.5 5 11694514 (2), 11052943 (1), 18923421 (1), 10219243 (1)
    glucose 3.63 2 11694514 (1), 12456725 (1)
    lipid 0 6 17988218 (2), 12477732 (2), 19824478 (1), 17302440 (1)
    latex 0 2 11401525 (1), 12551957 (1)
    adp 0 3 11792818 (2)

    Search CenterWatch for drugs/clinical trials and news about WASL 

    Transcripts
    for WASL gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WASL gene: 
    NM_003941.2  

    Unigene Clusters for WASL:

    Wiskott-Aldrich syndrome-like
    Hs.143728  [show with all ESTs], Hs.731519  [show with all ESTs]
    Unigene Representative Sequences: BX640852, NM_003941
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000223023(uc003vkz.3) ENST00000470644

    miRNA
    Products:             		 OriGene 3'-UTR Clone: WASL
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WASL
    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate WASL (see all 74):
    hsa-miR-520f hsa-miR-3146 hsa-miR-15a hsa-miR-374a hsa-miR-3613-3p hsa-miR-3116 hsa-miR-130b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: WASL 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WASL (see all 7)
    OriGene shRNA RFP: WASL
    OriGene siRNA: WASL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WASL
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WASL (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WASL
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: WASL (NM_003941)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WASL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WASL 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WASL
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WASL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WASL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WASL

    Additional cDNA sequence: 

    AK023554.1 AK289795.1 AM295156.1 BC013776.1 BC028602.1 BC052955.1 CR749438.1 D88460.1 

    12 DOTS entries:

    DT.218480  DT.75117246  DT.95268724  DT.100769559  DT.121053298  DT.121053301  DT.121053311  DT.65287633 
    DT.75118576  DT.92421825  DT.100701098  DT.95265999 

    24/159 AceView cDNA sequences (see all 159):

    CB132489 W73531 AW044456 AI969375 BE891172 BU952498 CB127157 BQ286524 
    CD107134 BQ269867 CN484199 AI521769 CB123879 AI352141 BQ717939 AI653277 
    BU951055 AI620950 BE504979 BU902219 BQ425087 N34978 CD359638 AI761685 

    GeneLoc Exon Structure


    Expression
    for WASL gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WASL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGCATAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See WASL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WASL

    SOURCE GeneReport for Unigene clusters: Hs.143728 Hs.731519
        SABiosciences Expression via Pathway-Focused PCR Arrays including WASL: 
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WASL
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WASL
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WASL
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WASL
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASL

    Orthologs
    for WASL gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WASL gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves WASL1 Wiskott-Aldrich syndrome-like 82.94(n)
    91.47(a)    		   417750  NM_001199500.1  NP_001186429.1 
    lizard
    (Anolis carolinensis)    		 Reptilia WASL6
    		 --
    		 90(a)
    		 1 ↔ 1
    		 5(67388938-67427695)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.23062 Transcribed sequence with weak similarity to protein more 82.06(n)    142012988 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc554782 similar to Wiskott-Aldrich syndrome-like (human) 76.23(n)   394034  BC044180.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta WASp1 CG1520-PA 47.49(n)
    41.63(a)    		   43402  NM_143380.3  NP_651637.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea wsp-11 Protein WSP-1 48.7(n)
    37.3(a)    		   177616  NM_171393.4  NP_741459.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G273906
    		 proline-rich family protein
    		 16(a)
    		 1 → many
    		 2(11720484-11720888)


    ENSEMBL Gene Tree for WASL (if available)
    TreeFam Gene Tree for WASL (if available) 

    Paralogs
    for WASL gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WASL gene
    WASF22  WAS2  WASF32  WASF12  
    3 SIMAP similar genes for WASL using alignment to 4 protein entries:     WASL_HUMAN (see all proteins):
    DKFZp779G0847    WASP    WAS

    WASL for paralogs           About GeneDecksing



    Genomic Variants
    for WASL gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1122 NCBI SNPs in WASL are shown (see all 1122)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1460323401,2
    		C,--123321559(+) AAAAC-/AGAGTTT 1 -- ds50010--------
    rs1916265551,2
    		--123321805(+) GTTTCC/TCAACA 1 -- ds50010--------
    rs1418502261,2
    		--123321928(+) CTTCAC/TTATAC 1 -- ds50010--------
    rs7676371,2
    		C,F,A,H,--123321978(-) TTCATT/GTGTTT 1 -- ds500125Minor allele frequency- G:0.23NA NS EA WA CSA 2421
    rs1455665551,2
    		--123321987(+) AAACAC/TATTAT 1 -- ds50010--------
    rs1830833971,2
    		--123321997(+) TTTTAC/TTCTAT 1 -- ut310--------
    rs1176752921,2
    		C,F,--123322036(+) ATGATG/TAATTG 1 -- ut311Minor allele frequency- T:0.03NA 120
    rs1879587861,2
    		--123322110(+) TTCAGG/TTGTCT 1 -- ut310--------
    rs118811,2
    		C,--123322188(+) ATCACG/ATAGCA 1 -- ut31 ese34Minor allele frequency- A:0.01MN NA WA 306
    rs743350871,2
    		C,F,--123322263(+) GGAGAA/CTATAC 1 -- ut311Minor allele frequency- C:0.09WA 118

    HapMap Linkage Disequilibrium report for WASL (123321989 - 123389121 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for WASL: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WASL
    DNA2.0 Custom Variant and Variant Library Synthesis for WASL

    Disorders / Diseases
    for WASL gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WASL for disorders           About GeneDecksing

    OMIM gene information: 605056    OMIM disorders: --

    16 diseases for WASL:    About MalaCards
    wiskott-aldrich syndrome    cystic fibrosis    shigellosis    eczema
    fibrosis    thrombocytopenia    vaccinia    alzheimer's disease
    breast carcinoma    breast cancer    carcinoma    esophagitis
    cholesterol    tuberculosis    neuronitis    mycobacterium tuberculosis

    2 diseases from the University of Copenhagen DISEASES database for WASL:
    Shigellosis     Wiskott-Aldrich syndrome

    9 Novoseek disease relationships for WASL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 95.6 71 11952639 (2), 15085951 (2), 17092940 (2), 11432863 (2) (see all 59)
    scar1 86.1 8 11747816 (6), 14561714 (1), 11029465 (1)
    scar 40.2 7 12872157 (1), 19018480 (1), 10940259 (1), 11747836 (1) (see all 7)
    cancer 1.71 1 17985201 (1)
    shock 0 4 12871950 (2), 15791211 (1), 17535252 (1)
    metastasis 0 4 19373774 (1), 17985201 (1)
    tumors 0 11 17092940 (3), 19373774 (2), 15699051 (1)
    carcinoma 0 7 15084285 (2), 15362118 (1), 18362183 (1)
    cystic fibrosis 0 1 17306384 (1)


    Export disorders for WASL gene to outside databases

    Publications
    for WASL gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WASL gene, integrated from 9 sources (see all 225):
    (articles sorted by number of sources associating them with WASL)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of N-WASP homologs in human and rat brain. (PubMed id 9322739)1, 2, 3, 9 Fukuoka M....Takenawa T. (1997)
    2. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. (PubMed id 9422512)1, 3, 9 Miki H....Takenawa T. (1998)
    3. The structural basis of actin interaction with multiple WH2/beta- thymosin motif-containing proteins. (PubMed id 16531231)1, 2, 9 Aguda A.H.... Robinson R.C. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    6. Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility. (PubMed id 10491394)1, 2 Egile C.... Carlier M.-F. (1999)
    7. Neural Wiskott-Aldrich syndrome protein is implicated in the actin- based motility of Shigella flexneri. (PubMed id 9582270)1, 2 Suzuki T.... Sasakawa C. (1998)
    8. Translocation of N-WASP by nuclear localization and export signals into the nucleus modulates expression of HSP90. (PubMed id 12871950)1, 9 Suetsugu S. and Takenawa T. (2003)
    9. Interaction of HSP90 to N-WASP leads to activation and protection from proteasome-dependent degradation. (PubMed id 15791211)1, 9 Park S.J....Takenawa T. (2005)
    10. N-WASP is a putative tumour suppressor in breast cancer cells, in vitro and in vivo, and is associated with clinical outcome in patients with breast cancer. (PubMed id 17985201)1, 9 Martin T.A....Jiang W.G. (2008)

    External Searches for WASL gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing WASL gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8976 HGNC: 12735 AceView: WASL Ensembl:ENSG00000106299 euGenes: HUgn8976
    ECgene: WASL Kegg: 8976 H-InvDB: WASL

    Other Databases showing WASL gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WASL gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WASL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WASL Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for WASL gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WASL gene:
    Search GeneIP for patents involving WASL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for WASL gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of WASL
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for WASL (N-WASP)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for WASL   OriGene shRNA RFP for WASL  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WASL   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WASL  
     OriGene Protein Over-expression Lysate for WASL   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for WASL   OriGene 3'-UTR Clone for WASL  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WASL   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WASL  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for WASL   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for WASL   OriGene Custom Protein Services for WASL  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WASL
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WASL
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WASL
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WASL
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WASL
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WASL
     GenScript Custom Purified and Recombinant Proteins Services for WASL GenScript cDNA clones with any tag delivered in your preferred vector for WASL
     GenScript Custom Assay Services for WASL GenScript Custom Superior Antibodies Services for WASL
     GenScript Custom overexpressing Cell Line Services for WASL CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for WASL  (N-WASP)

     Regulatory tfbs in WASL promoter
     Search Chromatin IP Primers for WASL
     RT2 qPCR Primer Assay in human, mouse, rat WASL
     GNC Network for WASL
     SABiosciences PCR Arrays including human, mouse, rat WASL
     Tocris compounds for WASL
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     WASL antibodies
     WASL proteins
     WASL lysates
     Antibodies for WASL
     See all of Abcam's Antibodies, Kits and Proteins for WASL
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     WASL Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for WASL
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASL
     SwitchGear 3'UTR luciferase reporter plasmids for WASL
     SwitchGear Promoter luciferase reporter plasmids for WASL
     ThermoFisher Antibodies for WASL
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WASL
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      WASL gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4