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Aliases for WASL Gene

Aliases for WASL Gene

  • Wiskott-Aldrich Syndrome Like 2 3 5
  • N-WASP 3 4
  • Neural Wiskott-Aldrich Syndrome Protein 3
  • Wiskott-Aldrich Syndrome-Like 2
  • NWASP 3
  • WASPB 3

External Ids for WASL Gene

Previous GeneCards Identifiers for WASL Gene

  • GC07M121799
  • GC07M122862
  • GC07M122876
  • GC07M122915
  • GC07M123109
  • GC07M123321
  • GC07M117685

Summaries for WASL Gene

Entrez Gene Summary for WASL Gene

  • This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]

GeneCards Summary for WASL Gene

WASL (Wiskott-Aldrich Syndrome Like) is a Protein Coding gene. Diseases associated with WASL include Wiskott-Aldrich Syndrome and Vaccinia. Among its related pathways are Development EGFR signaling via small GTPases and PAK Pathway. Gene Ontology (GO) annotations related to this gene include actin binding and GTPase regulator activity. An important paralog of this gene is WAS.

UniProtKB/Swiss-Prot for WASL Gene

  • Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis (By similarity).

Tocris Summary for WASL Gene

  • Actin is a ubiquitous globular protein that is one of the most highly-conserved proteins known. It is found in two main states: G-actin is the globular monomeric form, whereas F-actin forms helical polymers. Both G- and F-actin are intrinsically flexible structures.

Gene Wiki entry for WASL Gene

Additional gene information for WASL Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WASL Gene

Genomics for WASL Gene

GeneHancer (GH) Regulatory Elements for WASL Gene

Promoters and enhancers for WASL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I123745 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 562.8 +0.8 774 6.1 CLOCK ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 MEF2D WASL ENSG00000272686 HYAL4 PIR33062 GC07P123667
GH07I123726 Enhancer 1 Ensembl ENCODE 22.4 +21.8 21762 0.9 HDAC1 FOXA2 ARNT ZSCAN4 FEZF1 CHAMP1 ZNF335 ZNF366 CEBPB ZNF398 WASL RNU6-11P ENSG00000272686 GC07P123667
GH07I123769 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -21.4 -21369 2.1 PKNOX1 FOXA2 NFIB BATF RAD21 RFX5 RCOR1 ATF7 ETV6 FOS WASL LMOD2 PIR59988 RNU6-11P
GH07I123725 Enhancer 0.6 Ensembl 22.9 +23.4 23370 0.2 PKNOX1 TFE3 FOXA2 TEAD1 MAX HMG20A ZIC2 OSR2 PRDM6 HNF1A WASL RNU6-11P ENSG00000272686 GC07P123667
GH07I123655 Promoter/Enhancer 1.1 EPDnew ENCODE dbSUPER 10.7 +92.9 92922 2.3 MCM7 ZBTB40 LMOD2 WASL HYAL4 GC07P123667
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WASL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WASL gene promoter:

Genomic Locations for WASL Gene

Genomic Locations for WASL Gene
chr7:123,681,927-123,749,071
(GRCh38/hg38)
Size:
67,145 bases
Orientation:
Minus strand
chr7:123,321,989-123,389,121
(GRCh37/hg19)

Genomic View for WASL Gene

Genes around WASL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WASL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WASL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WASL Gene

Proteins for WASL Gene

  • Protein details for WASL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00401-WASL_HUMAN
    Recommended name:
    Neural Wiskott-Aldrich syndrome protein
    Protein Accession:
    O00401
    Secondary Accessions:
    • A1JUI9
    • Q7Z746

    Protein attributes for WASL Gene

    Size:
    505 amino acids
    Molecular mass:
    54827 Da
    Quaternary structure:
    • Binds actin and the Arp2/3 complex. Interacts with CDC42. Binds to SH3 domains of GRB2. Interacts with the C-terminal SH3 domain of DNMBP. Interacts with SNX9. Interacts with the WW domains of PRPF40A/FBP11. Interacts with PTK2/FAK1. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with NOSTRIN. Interacts with Shigella flexneri protein IcsA. The interaction with IcsA enhances the affinity of WASL for Arp2/3, thus assembling a tight complex which has maximal activity in actin assembly. Interacts with E.coli effector protein EspF(U). Identified in a complex containing at least WASL, BAIAP2L1 and E.coli EspF(U). Binds to TNK2. Interacts with SNX33.

    Three dimensional structures from OCA and Proteopedia for WASL Gene

neXtProt entry for WASL Gene

Post-translational modifications for WASL Gene

  • Phosphorylation at Ser-242, Tyr-256, Ser-484 and Ser-485 enhances actin polymerization activity.

Other Protein References for WASL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WASL Gene

Domains & Families for WASL Gene

Gene Families for WASL Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WASL Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WASL: view

No data available for UniProtKB/Swiss-Prot for WASL Gene

Function for WASL Gene

Molecular function for WASL Gene

GENATLAS Biochemistry:
Wiskott-Aldrich syndrome protein-like,64kDa,neural,concentrated at the nerve terminal region,inducing long actin microspikes when coexpressed with active CDC42
UniProtKB/Swiss-Prot Function:
Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis (By similarity).

Phenotypes From GWAS Catalog for WASL Gene

Gene Ontology (GO) - Molecular Function for WASL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 11231575
GO:0030695 GTPase regulator activity TAS 9422512
genes like me logo Genes that share ontologies with WASL: view
genes like me logo Genes that share phenotypes with WASL: view

Animal Model Products

CRISPR Products

miRNA for WASL Gene

miRTarBase miRNAs that target WASL

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WASL

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WASL Gene

Localization for WASL Gene

Subcellular locations from UniProtKB/Swiss-Prot for WASL Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated. Exported from the nucleus by an nuclear export signal (NES)-dependent mechanism to the cytoplasm. {ECO:0000250 UniProtKB:Q91YD9}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WASL gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 2
golgi apparatus 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WASL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with WASL: view

Pathways & Interactions for WASL Gene

genes like me logo Genes that share pathways with WASL: view

SIGNOR curated interactions for WASL Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for WASL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006461 protein complex assembly TAS 9422512
GO:0006900 vesicle budding from membrane ISS --
GO:0006928 movement of cell or subcellular component TAS 9422512
genes like me logo Genes that share ontologies with WASL: view

Drugs & Compounds for WASL Gene

(8) Drugs for WASL Gene - From: ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Latrunculin A Experimental Pharma Inhibitor of actin assembly and polymerization 0
187-1, N-WASP inhibitor Pharma 0

(9) Additional Compounds for WASL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for WASL Gene

Compound Action Cas Number
187-1, N-WASP inhibitor N-WASP inhibitor; inhibits actin assembly 380488-27-7
CK 666 Arp2/3 inhibitor; inhibits actin polymerization 442633-00-3
CK 869 Arp2/3 inhibitor; inhibits actin polymerization 388592-44-7
Latrunculin A Inhibitor of actin assembly and polymerization 76343-93-6
Wiskostatin N-WASP inhibitor; inhibits Arp2/3 activation 253449-04-6

(1) ApexBio Compounds for WASL Gene

Compound Action Cas Number
187-1, N-WASP inhibitor 380488-27-7
genes like me logo Genes that share compounds with WASL: view

Drug Products

Transcripts for WASL Gene

mRNA/cDNA for WASL Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(159) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WASL Gene

Wiskott-Aldrich syndrome-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WASL

Alternative Splicing Database (ASD) splice patterns (SP) for WASL Gene

No ASD Table

Relevant External Links for WASL Gene

GeneLoc Exon Structure for
WASL
ECgene alternative splicing isoforms for
WASL

Expression for WASL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WASL Gene

Protein differential expression in normal tissues from HIPED for WASL Gene

This gene is overexpressed in Frontal cortex (10.4), Uterus (7.9), and Testis (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WASL Gene



Protein tissue co-expression partners for WASL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WASL Gene:

WASL

SOURCE GeneReport for Unigene cluster for WASL Gene:

Hs.143728

Evidence on tissue expression from TISSUES for WASL Gene

  • Nervous system(4.9)
  • Skin(3)
  • Kidney(2.8)
  • Heart(2.2)
  • Muscle(2.2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with WASL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WASL Gene

Orthologs for WASL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WASL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WASL 33 34
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia WASL 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WASL 34
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wasl 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WASL 34
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 89 (a)
OneToMany
-- 34
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves WASL 34
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WASL 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2306 33
zebrafish
(Danio rerio)
Actinopterygii wasla 34
  • 75 (a)
OneToMany
waslb 34
  • 66 (a)
OneToMany
zgc55478 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4194 33
fruit fly
(Drosophila melanogaster)
Insecta WASp 34
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LAS17 34
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5291 34
  • 45 (a)
OneToMany
Species where no ortholog for WASL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WASL Gene

ENSEMBL:
Gene Tree for WASL (if available)
TreeFam:
Gene Tree for WASL (if available)

Paralogs for WASL Gene

Paralogs for WASL Gene

(3) SIMAP similar genes for WASL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WASL: view

Variants for WASL Gene

Sequence variations from dbSNP and Humsavar for WASL Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000001061 -- 123,730,913(-) T/G intron_variant
rs1000044221 -- 123,728,002(-) T/C intron_variant
rs1000116087 -- 123,718,996(-) G/A intron_variant
rs1000176292 -- 123,748,862(-) G/A 5_prime_UTR_variant
rs1000198167 -- 123,722,159(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WASL Gene

Variant ID Type Subtype PubMed ID
esv3572122 CNV loss 25503493
esv3891198 CNV gain 25118596

Variation tolerance for WASL Gene

Residual Variation Intolerance Score: 25.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WASL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WASL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WASL Gene

Disorders for WASL Gene

MalaCards: The human disease database

(5) MalaCards diseases for WASL Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search WASL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WASL

genes like me logo Genes that share disorders with WASL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WASL Gene

Publications for WASL Gene

  1. Identification of N-WASP homologs in human and rat brain. (PMID: 9322739) Fukuoka M … Takenawa T (Gene 1997) 2 3 4 22 58
  2. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. (PMID: 9422512) Miki H … Takenawa T (Nature 1998) 2 3 22 58
  3. Interactions of isolated C-terminal fragments of neural Wiskott-Aldrich syndrome protein (N-WASP) with actin and Arp2/3 complex. (PMID: 22847007) Gaucher JF … Carlier MF (The Journal of biological chemistry 2012) 3 4 58
  4. Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly. (PMID: 22921828) Aitio O … Permi P (Structure (London, England : 1993) 2012) 3 4 58
  5. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C … Soranzo N (Nature 2011) 3 44 58

Products for WASL Gene

  • Addgene plasmids for WASL

Sources for WASL Gene

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