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WASL Gene

protein-coding   GIFtS: 62
GCID: GC07M123321

Wiskott-Aldrich Syndrome-Like

  See WASL-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Wiskott-Aldrich Syndrome-Like1 2
N-WASP2 3
NWASP2
Neural Wiskott-Aldrich Syndrome Protein2

External Ids:    HGNC: 127351   Entrez Gene: 89762   Ensembl: ENSG000001062997   OMIM: 6050565   UniProtKB: O004013   

Export aliases for WASL gene to outside databases

Previous GC identifers: GC07M121799 GC07M122862 GC07M122876 GC07M122915 GC07M123109 GC07M117685


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WASL Gene:
This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins
share similar domain structure, and associate with a variety of signaling molecules to alter the actin
cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins
involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related
protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and
in neurite extension. (provided by RefSeq, Jul 2013)

GeneCards Summary for WASL Gene:
WASL (Wiskott-Aldrich syndrome-like) is a protein-coding gene. Diseases associated with WASL include wiskott-aldrich syndrome. GO annotations related to this gene include actin binding and small GTPase regulator activity. An important paralog of this gene is WAS.

UniProtKB/Swiss-Prot: WASL_HUMAN, O00401
Function: Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex.
Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1
and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression

summary for WASL Gene:
Neural Wiskott-Aldrich syndrome protein (N-WASP) is a member of the Wiskott-Aldrich syndrome-like (WASL)
protein family. It is ubiquitously expressed and regulates actin polymerization by activating the Arp2/3
complex.

Gene Wiki entry for WASL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the WASL gene promoter:
         Nkx3-1   Elk-1   AML1a   Nkx3-1 v1   AP-4   C/EBPalpha   GATA-1   RORalpha1   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): WASL promoter sequence
   Search Chromatin IP Primers for WASL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WASL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.3   Ensembl cytogenetic band:  7q31.32   HGNC cytogenetic band: 7q31.3

WASL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WASL gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M123321:  view genomic region     (about GC identifiers)

Start:
123,321,989 bp from pter      End:
123,389,121 bp from pter
Size:
67,133 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 122,710,624-122,777,740     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WASL_HUMAN, O00401 (See protein sequence)
Recommended Name: Neural Wiskott-Aldrich syndrome protein  
Size: 505 amino acids; 54827 Da
Subunit: Binds actin and the Arp2/3 complex. Interacts with CDC42. Binds to SH3 domains of GRB2. Interacts with
the C-terminal SH3 domain of DNMBP. Interacts with SNX9. Interacts with the WW domains of PRPF40A/FBP11.
Interacts with PTK2/FAK1. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with NOSTRIN.
Interacts with Shigella flexneri protein IcsA. The interaction with IcsA enhances the affinity of WASL for
Arp2/3, thus assembling a tight complex which has maximal activity in actin assembly. Interacts with E.coli
effector protein EspF(U). Identified in a complex containing at least WASL, BAIAP2L1 and E.coli EspF(U). Binds to
TNK2. Interacts with SNX33
5 PDB 3D structures from and Proteopedia for WASL:
2FF3 (3D)        2LNH (3D)        2VCP (3D)        4CC2 (3D)        4CC7 (3D)    
Secondary accessions: A1JUI9 Q7Z746

Explore the universe of human proteins at neXtProt for WASL: NX_O00401

Explore proteomics data for WASL at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-242, Tyr-256, Ser-484 and Ser-485 enhances actin polymerization activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WASL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003932.3  
    ENSEMBL proteins: 
     ENSP00000223023  
    Reactome Protein details: O00401

    WASL Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for WASL
    OriGene Protein Over-expression Lysate for WASL
    OriGene MassSpec for WASL
    OriGene Custom Protein Services for WASL
    GenScript Custom Purified and Recombinant Proteins Services for WASL
    Novus Biologicals WASL Proteins
    Novus Biologicals WASL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for WASL 

     
    antibodies-online proteins for WASL (12 products) 

     
    antibodies-online peptides for WASL

    WASL Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of WASL
    R&D Systems Antibodies for WASL (N-WASP)
    Cell Signaling Technology (CST) Antibodies for WASL  (N-WASP)
    OriGene Antibodies for WASL
    OriGene Custom Antibody Services for WASL
    Novus Biologicals WASL Antibodies
    Abcam antibodies for WASL
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for WASL
    LSBio Antibodies in human, mouse, rat for WASL
    antibodies-online antibodies for WASL (93 products) 

    WASL Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for WASL
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WASL
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for WASL 
    antibodies-online kits for WASL (14 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR027641 WASP
     IPR000095 CRIB_dom
     IPR011993 PH_like_dom
     IPR011026 WASP_C
     IPR003124 WH2_dom

    Graphical View of Domain Structure for InterPro Entry O00401

    ProtoNet protein and cluster: O00401

    1 Blocks protein domain: IPB003124 Actin-binding WH2

    UniProtKB/Swiss-Prot: WASL_HUMAN, O00401
    Similarity: Contains 1 CRIB domain
    Similarity: Contains 1 WH1 domain
    Similarity: Contains 2 WH2 domains


    Find genes that share domains with WASL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WASL_HUMAN, O00401
    Function: Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex.
    Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1
    and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression

         Genatlas biochemistry entry for WASL:
    Wiskott-Aldrich syndrome protein-like,64kDa,neural,concentrated at the nerve terminal region,inducing long actin
    microspikes when coexpressed with active CDC42

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005083small GTPase regulator activity TAS9422512
    GO:0005515protein binding IPI11231575
         
    Find genes that share ontologies with WASL           About GenesLikeMe


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Wasl):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  immune system  mortality/aging  nervous system 
     normal  renal/urinary system 

    Find genes that share phenotypes with WASL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for WASL: Wasltm1.1Sbs Wasltm1.1Cgn Wasltm1Sbs

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WASL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WASL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WASL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WASL

    miRNA
    Products:
        
    miRTarBase miRNAs that target WASL:
    hsa-mir-92a-3p (MIRT049810), hsa-let-7b-5p (MIRT051960), hsa-mir-17-5p (MIRT051048)

    Block miRNA regulation of human, mouse, rat WASL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WASL (see all 74):
    hsa-miR-520f hsa-miR-3146 hsa-miR-15a hsa-miR-374a hsa-miR-3613-3p hsa-miR-3116 hsa-miR-130b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidWASL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WASL
    Predesigned siRNA for gene silencing in human, mouse, rat WASL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WASL

    Clone
    Products:
         
    OriGene clones in human, mouse for WASL (see all 6)
    OriGene ORF clones in mouse, rat for WASL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WASL (NM_003941)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WASL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WASL
    Addgene plasmids for WASL 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for WASL
    Browse ESI BIO Cell Lines and PureStem Progenitors for WASL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASL

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12178) for WASL 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WASL_HUMAN, O00401: Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Note=Preferentially
    localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    plasma membrane4
    nucleus3
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0015629actin cytoskeleton TAS9422512
    GO:0016023cytoplasmic membrane-bounded vesicle ISS--

    Find genes that share ontologies with WASL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WASL About   (see all 37)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.43
    Cytoskeleton remodeling Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    2Metabolism of nitric oxide
    Metabolism of nitric oxide
    eNOS activation and regulation0.00
    NOSTRIN mediated eNOS trafficking0.00
    3Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    4L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    5Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    CDC42 Pathway0.41


    Find genes that share SuperPaths with WASL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WASL (see all 9)
        Actin-Based Motility by Rho Family GTPases
    Guidance Cues and Growth Cone Motility
    CDC42 Pathway
    PDGF Pathway
    Signaling by Slit

    1 Cell Signaling Technology (CST) Pathway for WASL
        Cytoskeletal Signaling

    Selected GeneGo (Thomson Reuters) Pathways for WASL (see all 7)
        Cytoskeleton remodeling Role of PDGFs in cell migration
    Cell adhesion Integrin-mediated cell adhesion and migration
    Development Slit-Robo signaling
    Cytoskeleton remodeling CDC42 in cellular processes
    Cytoskeleton remodeling Reverse signaling by ephrin B

    Selected BioSystems Pathways for WASL (see all 10)
        EGFR1 Signaling Pathway
    G13 Signaling Pathway
    Pathogenic Escherichia coli infection
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    EGF receptor (ErbB1) signaling pathway

    4 Reactome Pathways for WASL
        Nephrin interactions
    NOSTRIN mediated eNOS trafficking
    Regulation of actin dynamics for phagocytic cup formation
    DCC mediated attractive signaling


    Selected Kegg Pathways  (Kegg details for WASL) (see all 8):
        Chemokine signaling pathway
    Adherens junction
    Fc gamma R-mediated phagocytosis
    Regulation of actin cytoskeleton
    Bacterial invasion of epithelial cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WASL: 
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WASL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WASL (O004011, 2, 3 ENSP000002230234) via UniProtKB, MINT, STRING, and/or I2D (see all 241)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CIB1Q998281, 2, 3, ENSP000003338734EBI-957615,EBI-372594 MINT-1894563 MINT-1894734 MINT-1894761 MINT-2748633 MINT-1894885 MINT-1894939 MINT-2748609 I2D: score=1 STRING: ENSP00000333873
    GRB2P629931, 3, ENSP000003390074EBI-957615,EBI-401755 I2D: score=5 STRING: ENSP00000339007
    CTTNQ142472, 3, ENSP000003018434MINT-6541916 I2D: score=3 STRING: ENSP00000301843
    ITGA2P173012, 3, ENSP000002965854MINT-1895068 I2D: score=1 STRING: ENSP00000296585
    ITSN1Q158112, 3, ENSP000003707194MINT-14607 MINT-14605 MINT-14606 MINT-7302543 MINT-14608 I2D: score=3 STRING: ENSP00000370719
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006461protein complex assembly TAS9422512
    GO:0006900membrane budding ISS--
    GO:0006928cellular component movement TAS9422512

    Find genes that share ontologies with WASL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for WASL available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CK 666Arp2/3 inhibitor; inhibits actin polymerization[442633-00-3]
    Latrunculin AInhibitor of actin assembly and polymerization[76343-93-6]
    Cytochalasin DDisrupts actin filament function[22144-77-0]
    JasplakinolideStabilizes F-actin; promotes actin polymerization[102396-24-7]
    Thymosin beta4Potent actin polymerization regulator[77591-33-4]

    Selected Novoseek inferred chemical compound relationships for WASL gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskostatin 95.1 13 17405146 (2), 15235593 (2), 18667055 (2), 15800060 (1) (see all 8)
    pip2 60.7 8 8895577 (2), 12147689 (2), 11792818 (1), 17302440 (1) (see all 6)
    tyrosine 36.2 19 12431372 (4), 8895577 (2), 17474908 (2), 14676198 (2) (see all 10)
    proline 22.9 3 17229736 (1), 12147689 (1), 10973991 (1)
    phosphoinositide 22.4 4 16949824 (1), 10953003 (1), 11865026 (1)
    phosphatidylinositol 10.5 5 11694514 (2), 11052943 (1), 18923421 (1), 10219243 (1)
    glucose 3.63 2 11694514 (1), 12456725 (1)
    lipid 0 6 17988218 (2), 12477732 (2), 19824478 (1), 17302440 (1)
    latex 0 2 11401525 (1), 12551957 (1)
    adp 0 3 11792818 (2)



    Find genes that share compounds with WASL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WASL gene: 
    NM_003941.3  

    Unigene Cluster for WASL:

    Wiskott-Aldrich syndrome-like
    Hs.143728  [show with all ESTs]
    Unigene Representative Sequence: BX640852
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000223023(uc003vkz.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate WASL (see all 74):
    hsa-miR-520f hsa-miR-3146 hsa-miR-15a hsa-miR-374a hsa-miR-3613-3p hsa-miR-3116 hsa-miR-130b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidWASL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WASL
    Predesigned siRNA for gene silencing in human, mouse, rat WASL
    Clone
    Products:
         
    OriGene clones in human, mouse for WASL (see all 6)
    OriGene ORF clones in mouse, rat for WASL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WASL (NM_003941)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WASL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WASL
    Addgene plasmids for WASL 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for WASL
    OriGene qSTAR qPCR primer pairs in human, mouse for WASL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WASL
      QuantiTect SYBR Green Assays in human, mouse, rat WASL
      QuantiFast Probe-based Assays in human, mouse, rat WASL
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12178) for WASL 

    Additional mRNA sequence: 

    AK131016.1 BX640852.1 

    6 DOTS entries:

    DT.218480  DT.75117246  DT.95268724  DT.100769559  DT.75118576  DT.95265999 

    Selected AceView cDNA sequences (see all 159):

    BU902219 CD107134 N34978 AW044456 W73531 BE891172 BQ269867 CD359638 
    AI620950 AI761685 AI352141 BU952498 BU951055 AI969375 CB127157 AI521769 
    CN484199 BQ717939 AI653277 CB132489 BM751087 CB123879 BQ425087 BE504979 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    WASL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCATAATA
    WASL Expression
    About this image


    WASL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    WASL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WASL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.143728
        Pathway & Disease-focused RT2 Profiler PCR Arrays including WASL: 
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Cell Motility in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for WASL gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wasl5 Wiskott-Aldrich syndrome-like (human)   --   6 (11.28 cM) 24613805 
    chicken
    (Gallus gallus)
    Aves WASL6
    Gallus gallus Wiskott-Aldrich syndrome-like (WASL)...
    91(a)
    1 ↔ 1
    1(21980330-22030621)
    lizard
    (Anolis carolinensis)
    Reptilia WASL6
    Wiskott-Aldrich syndrome-like
    88(a)
    1 ↔ 1
    5(67388938-67431696)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.23062 Transcribed sequence with weak similarity to protein more 82.06(n)    142012988 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc554782 similar to Wiskott-Aldrich syndrome-like (human) 76.23(n)   394034  BC044180.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta WASp6
    WASp
    36(a)
    1 → many
    3R(24650228-24657757)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LAS176
    Actin assembly factor, activates the Arp2/3 protei...
    21(a)
    1 → many
    XV(675939-677840) YOR181W


    ENSEMBL Gene Tree for WASL (if available)
    TreeFam Gene Tree for WASL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WASL gene
    WAS2  
    3 SIMAP similar genes for WASL using alignment to 2 protein entries:     WASL_HUMAN (see all proteins):
    DKFZp779G0847    WASP    WAS

    Find genes that share paralogs with WASL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WASL (see all 1313)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460323401,2
    C--123321559(+) AAAAC-/AGAGTTT 1 -- ds50010--------
    rs1916265551,2
    --123321805(+) GTTTCC/TCAACA 1 -- ds50010--------
    rs1418502261,2
    --123321928(+) CTTCAC/TTATAC 1 -- ds50010--------
    rs7676371,2
    C,F,A,H--123321978(-) TTCATT/GTGTTT 1 -- ds500125Minor allele frequency- G:0.23NA NS EA WA CSA 2421
    rs1455665551,2
    --123321987(+) AAACAC/TATTAT 1 -- ds50010--------
    rs1830833971,2
    --123321997(+) TTTTAC/TTCTAT 1 -- ut310--------
    rs1176752921,2
    C,F--123322036(+) ATGATG/TAATTG 1 -- ut311Minor allele frequency- T:0.03NA 120
    rs1879587861,2
    --123322110(+) TTCAGG/TTGTCT 1 -- ut310--------
    rs118811,2
    C,F--123322188(+) ATCACG/ATAGCA 1 -- ut31 ese34Minor allele frequency- A:0.01MN NA WA 306
    rs743350871,2
    C,F--123322263(+) GGAGAA/CTATAC 1 -- ut311Minor allele frequency- C:0.09WA 118

    HapMap Linkage Disequilibrium report for WASL (123321989 - 123389121 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for WASL: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WASL
    DNA2.0 Custom Variant and Variant Library Synthesis for WASL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605056    OMIM disorders: --

    1 disease for WASL:    
    About MalaCards
    wiskott-aldrich syndrome

    2 diseases from the University of Copenhagen DISEASES database for WASL:
    Shigellosis     Wiskott-Aldrich syndrome

    Find genes that share disorders with WASL           About GenesLikeMe

    9 Novoseek inferred disease relationships for WASL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 95.6 71 11952639 (2), 15085951 (2), 17092940 (2), 11432863 (2) (see all 59)
    scar1 86.1 8 11747816 (6), 14561714 (1), 11029465 (1)
    scar 40.2 7 12872157 (1), 19018480 (1), 10940259 (1), 11747836 (1) (see all 7)
    cancer 1.71 1 17985201 (1)
    shock 0 4 12871950 (2), 15791211 (1), 17535252 (1)
    metastasis 0 4 19373774 (1), 17985201 (1)
    tumors 0 11 17092940 (3), 19373774 (2), 15699051 (1)
    carcinoma 0 7 15084285 (2), 15362118 (1), 18362183 (1)
    cystic fibrosis 0 1 17306384 (1)

    Genetic Association Database (GAD): WASL

    Export disorders for WASL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WASL gene, integrated from 10 sources (see all 245):
    (articles sorted by number of sources associating them with WASL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of N-WASP homologs in human and rat brain. (PubMed id 9322739)1, 2, 3, 9 Fukuoka M.... Takenawa T. (Gene 1997)
    2. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. (PubMed id 9422512)1, 3, 9 Miki H....Takenawa T. (Nature 1998)
    3. The structural basis of actin interaction with multiple WH2/beta- thymosin motif-containing proteins. (PubMed id 16531231)1, 2, 9 Aguda A.H.... Robinson R.C. (Structure 2006)
    4. Interactions of isolated C-terminal fragments of neural Wiskott-Aldrich syndrome protein (N-WASP) with actin and Arp2/3 complex. (PubMed id 22847007)1, 2 Gaucher J.F....Carlier M.F. (J. Biol. Chem. 2012)
    5. New gene functions in megakaryopoiesis and platelet formation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (Nature 2011)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    8. Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility. (PubMed id 10491394)1, 2 Egile C.... Carlier M.-F. (J. Cell Biol. 1999)
    9. Neural Wiskott-Aldrich syndrome protein is implicated in the actin- based motility of Shigella flexneri. (PubMed id 9582270)1, 2 Suzuki T.... Sasakawa C. (EMBO J. 1998)
    10. Translocation of N-WASP by nuclear localization and export signals into the nucleus modulates expression of HSP90. (PubMed id 12871950)1, 9 Suetsugu S. and Takenawa T. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8976 HGNC: 12735 AceView: WASL Ensembl:ENSG00000106299 euGenes: HUgn8976
    ECgene: WASL Kegg: 8976 H-InvDB: WASL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WASL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WASL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WASL gene:
    Search GeneIP for patents involving WASL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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