WASL Gene
protein-coding GIFtS: 62
GCID: GC07M123321
|
|
Wiskott-Aldrich syndrome-like
| |
Aliases for WASL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Wiskott-Aldrich Syndrome-Like1 2 | | N-WASP1 2 3 | | NWASP1 2 | | Neural Wiskott-Aldrich Syndrome Protein2 | | Wiskott-Aldrich Syndrome Gene-Like2 |
Export aliases for WASL gene to outside databasesPrevious GC identifers: GC07M121799 GC07M122862 GC07M122876 GC07M122915 GC07M123109 GC07M117685 |
Summaries for WASL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for WASL: The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transductionof signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifssuggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studieshave demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known toregulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is ahomolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression inneural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes. (provided byRefSeq, Jul 2008) UniProtKB/Swiss-Prot: WASL_HUMAN, O00401Function: Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Binds toHSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression
summary
for WASL:Neural Wiskott-Aldrich syndrome protein (N-WASP) is a member of the Wiskott-Aldrich syndrome-like (WASL) protein family. It is ubiquitously expressed and regulates actin polymerization by activating the Arp2/3 complex. Gene Wiki entry for WASL
|
Genomic Views for WASL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the WASL gene promoter: Nkx3-1 Elk-1 AML1a Nkx3-1 v1 AP-4 C/EBPalpha GATA-1 RORalpha1 PPAR-gamma1 PPAR-gamma2 Other transcription factors
Search SABiosciences Chromatin IP Primers for WASL
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WASL |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31.3 Ensembl cytogenetic band: 7q31.32 HGNC cytogenetic band: 7q31.3WASL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M123321: view genomic region
(about GC identifiers)
Start:
|
123,321,989 bp from pter |
End:
|
123,389,121 bp from pter |
Size:
|
67,133 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 122,710,624-122,777,740 |
|
Proteins for WASL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: WASL_HUMAN, O00401 (See
protein sequence)Recommended Name: Neural Wiskott-Aldrich syndrome protein Size: 505 amino acids; 54827 Da
Subunit: Binds actin and the Arp2/3 complex. Interacts with CDC42. Binds to SH3 domains of GRB2. Interacts with theC-terminal SH3 domain of DNMBP. Interacts with SNX9. Interacts with the WW domains of PRPF40A/FBP11. Interacts withPTK2/FAK1 (By similarity). Interacts with NOSTRIN. Interacts with Shigella flexneri protein IcsA. The interaction withIcsA enhances the affinity of WASL for Arp2/3, thus assembling a tight complex which has maximal activity in actinassembly. Interacts with E.coli effector protein EspF(U). Identified in a complex containing at least WASL, BAIAP2L1and E.coli EspF(U). Binds to TNK2
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Note=Preferentially localizedin the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity)
3 PDB 3D structures from and Proteopedia for WASL:2FF3 (3D)
  2LNH (3D)
  2VCP (3D)
 
Secondary accessions: Q7Z746Explore the universe of human proteins at neXtProt for WASL: NX_O00401
Post-translational modifications:
Phosphorylation at Ser-242, Tyr-256, Ser-484 and Ser-485 enhances actin polymerization activity1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00401 WASL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003932.3 ENSEMBL proteins: ENSP00000223023 ENSP00000417672 Reactome Protein details: O00401 Human Recombinant Protein Products:
Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table
WASL for ontologies About GeneDecksing
WASL Antibody Products: Assay Products for WASL: |
Protein
Domains / Families for WASL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WASL for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00401ProtoNet protein and cluster: O00401 1 Blocks protein family: IPB003124 Actin-binding WH2
UniProtKB/Swiss-Prot: WASL_HUMAN, O00401Similarity: Contains 1 CRIB domainSimilarity: Contains 1 WH1 domainSimilarity: Contains 2 WH2 domains |
Function for WASL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: WASL_HUMAN, O00401Function: Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Binds toHSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression Genatlas biochemistry entry for WASL:Wiskott-Aldrich syndrome protein-like,64kDa,neural,concentrated at the nerve terminal region,inducing long actinmicrospikes when coexpressed with active CDC42
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WASL (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WASL OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WASL (NM_003941) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WASL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WASL  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASL |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
WASL for ontologies About GeneDecksing
Animal Models: Mouse knock-outs for WASL: Wasltm1.1Sbs Wasltm1.1Cgn Wasltm1Sbs 11 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Wasl):
WASL for phenotypes About GeneDecksing
|
Pathways & Interactions for WASL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/36 super-pathways (see all 36) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of actin dynamics for phagocytic cup formation | | | 2 | Metabolism of nitric oxide | | | 3 | Cytoskeleton remodeling Slit-Robo signaling | | | 4 | Cell adhesion_Integrin-mediated cell adhesion and migration | | | 5 | G-protein signaling_RAC1 in cellular process | |
Pathway sources See GeneCards unified pathways Show all pathways
5/7 EMD Millipore Pathways for WASL (see all 7) 5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WASL (see all 9) 1
Cell Signaling Technology (CST) Pathway for WASL 5/7 GeneGo (Thomson Reuters) Pathways for WASL (see all 7) 5/10 BioSystems Pathways for WASL (see all 10) 
5/17
Reactome Pathways for WASL (see all 17)
5/7
Kegg Pathways (Kegg details for WASL) (see all 7):
WASL for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WASL
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/95 Interacting proteins for WASL (O004011, 2, 3 ENSP000002230234) via UniProtKB, MINT, STRING, and/or I2D (see all 95)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ITSN1 | Q158112, 3, ENSP000003707194 | MINT-14607 MINT-14605 MINT-14606 MINT-7302543 MINT-14608 I2D:
score=3 STRING: ENSP00000370719 | | CRK | P461082, 3, ENSP000003005744 | MINT-72620 MINT-72571 I2D:
score=1 STRING: ENSP00000300574 | | SNX9 | Q9Y5X12, 3, ENSP000003760244 | MINT-7302014 MINT-7302027 I2D:
score=1 STRING: ENSP00000376024 | | GRB2 | P629931, 3, ENSP000003390074 | EBI-957615,EBI-401755 I2D:
score=5 STRING: ENSP00000339007 | | CTTN | Q142472, 3, ENSP000003018434 | MINT-6541916 I2D:
score=3 STRING: ENSP00000301843 | About this table
Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table
WASL for ontologies About GeneDecksing
|
Drugs & Compounds for WASL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
WASL for compounds About GeneDecksing
Compounds for WASL available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Wiskostatin | N-WASP inhibitor; inhibits Arp2/3 activation | [253449-04-6] | 10/11 Novoseek chemical compound relationships for WASL gene (see all 11) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| wiskostatin |
95.1 |
13 |
17405146 (2), 15235593 (2), 18667055 (2), 15800060 (1) (see all 8) |
| pip2 |
60.7 |
8 |
8895577 (2), 12147689 (2), 11792818 (1), 17302440 (1) (see all 6) |
| tyrosine |
36.2 |
19 |
12431372 (4), 8895577 (2), 17474908 (2), 14676198 (2) (see all 10) |
| proline |
22.9 |
3 |
17229736 (1), 12147689 (1), 10973991 (1) |
| phosphoinositide |
22.4 |
4 |
16949824 (1), 10953003 (1), 11865026 (1) |
| phosphatidylinositol |
10.5 |
5 |
11694514 (2), 11052943 (1), 18923421 (1), 10219243 (1) |
| glucose |
3.63 |
2 |
11694514 (1), 12456725 (1) |
| lipid |
0 |
6 |
17988218 (2), 12477732 (2), 19824478 (1), 17302440 (1) |
| latex |
0 |
2 |
11401525 (1), 12551957 (1) |
| adp |
0 |
3 |
11792818 (2) |
Search CenterWatch for drugs/clinical trials and news about WASL 
|
Transcripts for WASL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for WASL gene: NM_003941.2 Unigene Clusters for WASL: Wiskott-Aldrich syndrome-like Hs.143728 [show with all ESTs], Hs.731519 [show with all ESTs]Unigene Representative Sequences: BX640852, NM_0039412 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000223023(uc003vkz.3) ENST00000470644
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WASL (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WASL OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WASL (NM_003941) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WASL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WASL  |
Additional cDNA sequence: AK023554.1 AK289795.1 AM295156.1 BC013776.1 BC028602.1 BC052955.1 CR749438.1 D88460.1 12 DOTS entries: DT.218480 DT.75117246 DT.95268724 DT.100769559 DT.121053298 DT.121053301 DT.121053311 DT.65287633 DT.75118576 DT.92421825 DT.100701098 DT.95265999 24/159 AceView cDNA sequences (see all 159): CB132489 W73531 AW044456 AI969375 BE891172 BU952498 CB127157 BQ286524 CD107134 BQ269867 CN484199 AI521769 CB123879 AI352141 BQ717939 AI653277 BU951055 AI620950 BE504979 BU902219 BQ425087 N34978 CD359638 AI761685 GeneLoc Exon Structure
|
Expression for WASL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WASL expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GAGCATAATA
About this image See WASL Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for WASL
SOURCE GeneReport for Unigene clusters: Hs.143728 Hs.731519 SABiosciences Expression via Pathway-Focused PCR Arrays including WASL:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WASL Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WASL | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WASL | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WASL | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASL |
Orthologs for WASL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WASL gene from 7/25 species (see all 25) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
WASL1 |
Wiskott-Aldrich syndrome-like |
82.94(n) 91.47(a) |
  |
417750 NM_001199500.1 NP_001186429.1 |
lizard (Anolis carolinensis) |
Reptilia |
WASL6 |
-- |
90(a) |
1 ↔ 1 |
5(67388938-67427695) |
tropical clawed frog (Xenopus tropicalis) |
Amphibia |
Str.23062 |
Transcribed sequence with weak similarity to protein more |
82.06(n) |
  |
142012988 |
zebrafish (Danio rerio) |
Actinopterygii |
zgc554782 |
similar to Wiskott-Aldrich syndrome-like (human) |
76.23(n) |
  |
394034 BC044180.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
WASp1 |
CG1520-PA |
47.49(n) 41.63(a) |
  |
43402 NM_143380.3 NP_651637.1 |
worm (Caenorhabditis elegans) |
Secernentea |
wsp-11 |
Protein WSP-1 |
48.7(n) 37.3(a) |
  |
177616 NM_171393.4 NP_741459.2 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
AT2G273906 |
proline-rich family protein |
16(a) |
1 → many |
2(11720484-11720888) |
ENSEMBL Gene Tree for WASL (if available) TreeFam Gene Tree for WASL (if available)  |
Paralogs for WASL gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for WASL gene
- WASF22 WAS2 WASF32 WASF12
3 SIMAP similar genes for WASL using alignment to 4 protein entries: WASL_HUMAN (see all proteins):DKFZp779G0847 WASP WAS
WASL for paralogs About GeneDecksing
|
Genomic Variants for WASL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 7 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for WASL (123321989 - 123389121 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for WASL: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WASL |
|
Disorders
/ Diseases for WASL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WASL for disorders About GeneDecksing
OMIM gene information: 605056
OMIM disorders: --
16 diseases for WASL: About MalaCardswiskott-aldrich syndrome cystic fibrosis shigellosis eczema fibrosis thrombocytopenia vaccinia alzheimer's disease breast carcinoma breast cancer carcinoma esophagitis cholesterol tuberculosis neuronitis mycobacterium tuberculosis 2 diseases from the University of Copenhagen DISEASES database for WASL:Shigellosis Wiskott-Aldrich syndrome 9 Novoseek disease relationships for WASL gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| wiskott-aldrich syndrome |
95.6 |
71 |
11952639 (2), 15085951 (2), 17092940 (2), 11432863 (2) (see all 59) |
| scar1 |
86.1 |
8 |
11747816 (6), 14561714 (1), 11029465 (1) |
| scar |
40.2 |
7 |
12872157 (1), 19018480 (1), 10940259 (1), 11747836 (1) (see all 7) |
| cancer |
1.71 |
1 |
17985201 (1) |
| shock |
0 |
4 |
12871950 (2), 15791211 (1), 17535252 (1) |
| metastasis |
0 |
4 |
19373774 (1), 17985201 (1) |
| tumors |
0 |
11 |
17092940 (3), 19373774 (2), 15699051 (1) |
| carcinoma |
0 |
7 |
15084285 (2), 15362118 (1), 18362183 (1) |
| cystic fibrosis |
0 |
1 |
17306384 (1) |
Export disorders for WASL gene to outside databases
|
Publications for WASL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WASL gene, integrated from 9 sources (see all 225): (articles sorted by number of sources associating them with WASL) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Identification of N-WASP homologs in human and rat brain. (PubMed id 9322739)1, 2, 3, 9 Fukuoka M....Takenawa T. (1997)
- Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. (PubMed id 9422512)1, 3, 9 Miki H....Takenawa T. (1998)
- The structural basis of actin interaction with multiple WH2/beta- thymosin motif-containing proteins. (PubMed id 16531231)1, 2, 9 Aguda A.H.... Robinson R.C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility. (PubMed id 10491394)1, 2 Egile C.... Carlier M.-F. (1999)
- Neural Wiskott-Aldrich syndrome protein is implicated in the actin- based motility of Shigella flexneri. (PubMed id 9582270)1, 2 Suzuki T.... Sasakawa C. (1998)
- Translocation of N-WASP by nuclear localization and export signals into the nucleus modulates expression of HSP90. (PubMed id 12871950)1, 9 Suetsugu S. and Takenawa T. (2003)
- Interaction of HSP90 to N-WASP leads to activation and protection from proteasome-dependent degradation. (PubMed id 15791211)1, 9 Park S.J....Takenawa T. (2005)
- N-WASP is a putative tumour suppressor in breast cancer cells, in vitro and in vivo, and is associated with clinical outcome in patients with breast cancer. (PubMed id 17985201)1, 9 Martin T.A....Jiang W.G. (2008)
|
External Searches for WASL gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing WASL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing WASL gene
(According to HUGE)
About This Section
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Specialized Databases showing WASL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
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About This Section
| Patent Information for WASL gene: Search GeneIP for patents involving WASL
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products for WASL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | OriGene Antibodies for WASL | | OriGene shRNA RFP for WASL | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WASL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WASL | | OriGene Protein Over-expression Lysate for WASL | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for WASL | | OriGene 3'-UTR Clone for WASL | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WASL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WASL | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | OriGene Purified Protein for WASL | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for WASL | | OriGene Custom Protein Services for WASL | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WASL | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WASL | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WASL | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WASL | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WASL | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WASL |
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| Antibodies & Assays for WASL  (N-WASP) |
| | | Tocris compounds for WASL |
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 | | WASL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASL |
|  |  |  | | | ThermoFisher Antibodies for WASL |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WASL |
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