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Aliases for WASL Gene

Aliases for WASL Gene

  • Wiskott-Aldrich Syndrome Like 2 3
  • Wiskott-Aldrich Syndrome-Like 2 3 5
  • N-WASP 3 4
  • NWASP 3
  • WASPB 3

External Ids for WASL Gene

Previous GeneCards Identifiers for WASL Gene

  • GC07M121799
  • GC07M122862
  • GC07M122876
  • GC07M122915
  • GC07M123109
  • GC07M123321
  • GC07M117685

Summaries for WASL Gene

Entrez Gene Summary for WASL Gene

  • This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]

GeneCards Summary for WASL Gene

WASL (Wiskott-Aldrich Syndrome Like) is a Protein Coding gene. Diseases associated with WASL include wiskott-aldrich syndrome and buruli ulcer. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include actin binding and GTPase regulator activity. An important paralog of this gene is WAS.

UniProtKB/Swiss-Prot for WASL Gene

  • Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.

Tocris Summary for WASL Gene

  • Actin is a ubiquitous globular protein that is one of the most highly-conserved proteins known. It is found in two main states: G-actin is the globular monomeric form, whereas F-actin forms helical polymers. Both G- and F-actin are intrinsically flexible structures.

Gene Wiki entry for WASL Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WASL Gene

Genomics for WASL Gene

Regulatory Elements for WASL Gene

Promoters for WASL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WASL on UCSC Golden Path with GeneCards custom track

Genomic Location for WASL Gene

Chromosome:
7
Start:
123,681,927 bp from pter
End:
123,749,071 bp from pter
Size:
67,145 bases
Orientation:
Minus strand

Genomic View for WASL Gene

Genes around WASL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WASL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WASL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WASL Gene

Proteins for WASL Gene

  • Protein details for WASL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00401-WASL_HUMAN
    Recommended name:
    Neural Wiskott-Aldrich syndrome protein
    Protein Accession:
    O00401
    Secondary Accessions:
    • A1JUI9
    • Q7Z746

    Protein attributes for WASL Gene

    Size:
    505 amino acids
    Molecular mass:
    54827 Da
    Quaternary structure:
    • Binds actin and the Arp2/3 complex. Interacts with CDC42. Binds to SH3 domains of GRB2. Interacts with the C-terminal SH3 domain of DNMBP. Interacts with SNX9. Interacts with the WW domains of PRPF40A/FBP11. Interacts with PTK2/FAK1. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with NOSTRIN. Interacts with Shigella flexneri protein IcsA. The interaction with IcsA enhances the affinity of WASL for Arp2/3, thus assembling a tight complex which has maximal activity in actin assembly. Interacts with E.coli effector protein EspF(U). Identified in a complex containing at least WASL, BAIAP2L1 and E.coli EspF(U). Binds to TNK2. Interacts with SNX33.

    Three dimensional structures from OCA and Proteopedia for WASL Gene

neXtProt entry for WASL Gene

Proteomics data for WASL Gene at MOPED

Post-translational modifications for WASL Gene

  • Phosphorylation at Ser-242, Tyr-256, Ser-484 and Ser-485 enhances actin polymerization activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WASL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for WASL (N-WASP)

No data available for DME Specific Peptides for WASL Gene

Domains & Families for WASL Gene

Gene Families for WASL Gene

Protein Domains for WASL Gene

Suggested Antigen Peptide Sequences for WASL Gene

Graphical View of Domain Structure for InterPro Entry

O00401

UniProtKB/Swiss-Prot:

WASL_HUMAN :
  • Contains 1 CRIB domain.
Domain:
  • Contains 1 CRIB domain.
  • Contains 1 WH1 domain.
  • Contains 2 WH2 domains.
genes like me logo Genes that share domains with WASL: view

Function for WASL Gene

Molecular function for WASL Gene

GENATLAS Biochemistry:
Wiskott-Aldrich syndrome protein-like,64kDa,neural,concentrated at the nerve terminal region,inducing long actin microspikes when coexpressed with active CDC42
UniProtKB/Swiss-Prot Function:
Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.
genes like me logo Genes that share phenotypes with WASL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for WASL

miRNA for WASL Gene

miRTarBase miRNAs that target WASL

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WASL Gene

Localization for WASL Gene

Subcellular locations from UniProtKB/Swiss-Prot for WASL Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated. Exported from the nucleus by an nuclear export signal (NES)-dependent mechanism to the cytoplasm. {ECO:0000250 UniProtKB:Q91YD9}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WASL Gene COMPARTMENTS Subcellular localization image for WASL gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
golgi apparatus 3
mitochondrion 2
endosome 1

Gene Ontology (GO) - Cellular Components for WASL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015629 actin cytoskeleton TAS 9422512
genes like me logo Genes that share ontologies with WASL: view

Pathways & Interactions for WASL Gene

genes like me logo Genes that share pathways with WASL: view

SIGNOR curated interactions for WASL Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for WASL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006900 membrane budding ISS --
GO:0006928 movement of cell or subcellular component TAS 9422512
GO:0007411 axon guidance TAS --
GO:0008154 actin polymerization or depolymerization TAS 9422512
genes like me logo Genes that share ontologies with WASL: view

Drugs & Compounds for WASL Gene

(3) Drugs for WASL Gene - From: Tocris and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Latrunculin A Experimental Pharma Inhibitor of actin assembly and polymerization 0

(12) Additional Compounds for WASL Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Wiskostatin
253449-04-6
187-1, N-WASP inhibitor
380488-27-7
CK 666
442633-00-3
CK 869
388592-44-7

(5) Tocris Compounds for WASL Gene

Compound Action Cas Number
187-1, N-WASP inhibitor N-WASP inhibitor; inhibits actin assembly 380488-27-7
CK 666 Arp2/3 inhibitor; inhibits actin polymerization 442633-00-3
CK 869 Arp2/3 inhibitor; inhibits actin polymerization 388592-44-7
Latrunculin A Inhibitor of actin assembly and polymerization 76343-93-6
Wiskostatin N-WASP inhibitor; inhibits Arp2/3 activation 253449-04-6
genes like me logo Genes that share compounds with WASL: view

Transcripts for WASL Gene

mRNA/cDNA for WASL Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(159) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WASL Gene

Wiskott-Aldrich syndrome-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WASL Gene

No ASD Table

Relevant External Links for WASL Gene

GeneLoc Exon Structure for
WASL
ECgene alternative splicing isoforms for
WASL

Expression for WASL Gene

mRNA expression in normal human tissues for WASL Gene

Protein differential expression in normal tissues from HIPED for WASL Gene

This gene is overexpressed in Frontal cortex (10.4), Uterus (7.9), and Testis (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WASL Gene



SOURCE GeneReport for Unigene cluster for WASL Gene Hs.143728

genes like me logo Genes that share expression patterns with WASL: view

Protein tissue co-expression partners for WASL Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WASL Gene

Orthologs for WASL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WASL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WASL 35
  • 99.67 (n)
  • 100 (a)
WASL 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WASL 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WASL 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Wasl 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WASL 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves WASL 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WASL 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2306 35
zebrafish
(Danio rerio)
Actinopterygii zgc55478 35
wasla 36
  • 75 (a)
OneToMany
waslb 36
  • 66 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4194 35
fruit fly
(Drosophila melanogaster)
Insecta WASp 36
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LAS17 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5291 36
  • 45 (a)
OneToMany
Species with no ortholog for WASL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WASL Gene

ENSEMBL:
Gene Tree for WASL (if available)
TreeFam:
Gene Tree for WASL (if available)

Paralogs for WASL Gene

Paralogs for WASL Gene

(3) SIMAP similar genes for WASL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WASL: view

Variants for WASL Gene

Sequence variations from dbSNP and Humsavar for WASL Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs11881 -- 123,682,134(+) ATCAC(A/G)TAGCA utr-variant-3-prime
rs13044 -- 123,682,662(+) AAAAA(A/T)TTTTT utr-variant-3-prime
rs767637 -- 123,681,924(-) TTCAT(G/T)TGTTT downstream-variant-500B
rs768680 -- 123,724,073(+) CCCCC(C/T)TCCCA intron-variant
rs1000204 -- 123,695,024(+) AAAAC(G/T)GAACA intron-variant

Variation tolerance for WASL Gene

Residual Variation Intolerance Score: 25.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WASL Gene

HapMap Linkage Disequilibrium report
WASL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for WASL Gene

Disorders for WASL Gene

MalaCards: The human disease database

(3) MalaCards diseases for WASL Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
wiskott-aldrich syndrome
  • wiskott syndrome
buruli ulcer
  • buruli ulcer disease
x-linked disease
- elite association - COSMIC cancer census association via MalaCards
Search WASL in MalaCards View complete list of genes associated with diseases

Relevant External Links for WASL

Genetic Association Database (GAD)
WASL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WASL
genes like me logo Genes that share disorders with WASL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WASL Gene

Publications for WASL Gene

  1. Identification of N-WASP homologs in human and rat brain. (PMID: 9322739) Fukuoka M. … Takenawa T. (Gene 1997) 2 3 4 23 67
  2. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. (PMID: 9422512) Miki H. … Takenawa T. (Nature 1998) 2 3 23
  3. The Toca-1-N-WASP complex links filopodial formation to endocytosis. (PMID: 19213734) Bu W. … Ahmed S. (J. Biol. Chem. 2009) 3 23
  4. N-WASP is a putative tumour suppressor in breast cancer cells, in vitro and in vivo, and is associated with clinical outcome in patients with breast cancer. (PMID: 17985201) Martin T.A. … Jiang W.G. (Clin. Exp. Metastasis 2008) 3 23
  5. N-wasp and the arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses. (PMID: 18430734) Wegner A.M. … Webb D.J. (J. Biol. Chem. 2008) 3 23

Products for WASL Gene

Sources for WASL Gene

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