External Ids for WASL Gene
Previous GeneCards Identifiers for WASL Gene
This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]
GeneCards Summary for WASL Gene
WASL (Wiskott-Aldrich Syndrome-Like) is a Protein Coding gene. Diseases associated with WASL include wiskott-aldrich syndrome and buruli ulcer. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include actin binding and GTPase regulator activity. An important paralog of this gene is WAS.
UniProtKB/Swiss-Prot for WASL Gene
Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.
Actin is a ubiquitous globular protein that is one of the most highly-conserved proteins known. It is found in two main states: G-actin is the globular monomeric form, whereas F-actin forms helical polymers. Both G- and F-actin are intrinsically flexible structures.