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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WASL Gene

protein-coding   GIFtS: 61
GCID: GC07M123321

Wiskott-Aldrich Syndrome-Like

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Wiskott-Aldrich Syndrome-Like1 2
N-WASP2 3
NWASP2
Neural Wiskott-Aldrich Syndrome Protein2

External Ids:    HGNC: 127351   Entrez Gene: 89762   Ensembl: ENSG000001062997   OMIM: 6050565   UniProtKB: O004013   

Export aliases for WASL gene to outside databases

Previous GC identifers: GC07M121799 GC07M122862 GC07M122876 GC07M122915 GC07M123109 GC07M117685


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WASL Gene:
This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins
share similar domain structure, and associate with a variety of signaling molecules to alter the actin
cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins
involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related
protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and
in neurite extension. (provided by RefSeq, Jul 2013)

GeneCards Summary for WASL Gene: 
WASL (Wiskott-Aldrich syndrome-like) is a protein-coding gene. Diseases associated with WASL include wiskott-aldrich syndrome, and shigellosis, and among its related super-pathways are Development Slit-Robo signaling and Regulation of actin dynamics for phagocytic cup formation. GO annotations related to this gene include actin binding and small GTPase regulator activity. An important paralog of this gene is WAS.

UniProtKB/Swiss-Prot: WASL_HUMAN, O00401
Function: Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Binds
to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90
expression

summary for WASL Gene:
Neural Wiskott-Aldrich syndrome protein (N-WASP) is a member of the Wiskott-Aldrich syndrome-like (WASL)
protein family. It is ubiquitously expressed and regulates actin polymerization by activating the Arp2/3
complex.

Gene Wiki entry for WASL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WASL gene promoter:
         Nkx3-1   Elk-1   AML1a   Nkx3-1 v1   AP-4   C/EBPalpha   GATA-1   RORalpha1   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): WASL promoter sequence
   Search SABiosciences Chromatin IP Primers for WASL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WASL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.3   Ensembl cytogenetic band:  7q31.32   HGNC cytogenetic band: 7q31.3

WASL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WASL gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M123321:  view genomic region     (about GC identifiers)

Start:
123,321,989 bp from pter      End:
123,389,121 bp from pter
Size:
67,133 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 122,710,624-122,777,740     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WASL_HUMAN, O00401 (See protein sequence)
Recommended Name: Neural Wiskott-Aldrich syndrome protein  
Size: 505 amino acids; 54827 Da
Subunit: Binds actin and the Arp2/3 complex. Interacts with CDC42. Binds to SH3 domains of GRB2. Interacts with
the C-terminal SH3 domain of DNMBP. Interacts with SNX9. Interacts with the WW domains of PRPF40A/FBP11.
Interacts with PTK2/FAK1. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with NOSTRIN.
Interacts with Shigella flexneri protein IcsA. The interaction with IcsA enhances the affinity of WASL for
Arp2/3, thus assembling a tight complex which has maximal activity in actin assembly. Interacts with E.coli
effector protein EspF(U). Identified in a complex containing at least WASL, BAIAP2L1 and E.coli EspF(U). Binds to
TNK2
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Note=Preferentially
localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity)
3 PDB 3D structures from and Proteopedia for WASL:
2FF3 (3D)        2LNH (3D)        2VCP (3D)    
Secondary accessions: Q7Z746

Explore the universe of human proteins at neXtProt for WASL: NX_O00401

Explore proteomics data for WASL at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Ser-242, Tyr-256, Ser-484 and Ser-485 enhances actin polymerization activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00401

  • WASL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WASL Protein Expression
    REFSEQ proteins: NP_003932.3  
    ENSEMBL proteins: 
     ENSP00000223023  
    Reactome Protein details: O00401
    Human Recombinant Protein Products for WASL: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for WASL
    OriGene Protein Over-expression Lysate for WASL
    OriGene MassSpec for WASL 
    OriGene Custom Protein Services for WASL
    GenScript Custom Purified and Recombinant Proteins Services for WASL
    Novus Biologicals WASL Proteins
    Novus Biologicals WASL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0015629actin cytoskeleton TAS9422512
    GO:0016023cytoplasmic membrane-bounded vesicle ISS--

    WASL for ontologies           About GeneDecksing



    WASL Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of WASL
    R&D Systems Antibodies for WASL (N-WASP)
    Cell Signaling Technology (CST) Antibodies for WASL  (N-WASP)
    OriGene Antibodies for WASL
    OriGene Custom Antibody Services for WASL
    GenScript Custom Superior Antibodies Services for WASL
    Novus Biologicals WASL Antibodies
    Abcam antibodies for WASL
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for WASL
    LSBio Antibodies in human, mouse, rat for WASL 

    Assay Products for WASL: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for WASL
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WASL
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR003124 WH2_dom
     IPR000095 PAK_box_Rho-bd
     IPR011993 PH_like_dom
     IPR000697 EVH1
     IPR011026 WASP_C

    Graphical View of Domain Structure for InterPro Entry O00401

    ProtoNet protein and cluster: O00401

    1 Blocks protein domain: IPB003124 Actin-binding WH2

    UniProtKB/Swiss-Prot: WASL_HUMAN, O00401
    Similarity: Contains 1 CRIB domain
    Similarity: Contains 1 WH1 domain
    Similarity: Contains 2 WH2 domains


    WASL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WASL_HUMAN, O00401
    Function: Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Binds
    to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90
    expression

         Genatlas biochemistry entry for WASL:
    Wiskott-Aldrich syndrome protein-like,64kDa,neural,concentrated at the nerve terminal region,inducing long actin
    microspikes when coexpressed with active CDC42

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005083small GTPase regulator activity TAS9422512
    GO:0005515protein binding IPI11231575
         
    WASL for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Wasl):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  immune system  mortality/aging  nervous system 
     normal  renal/urinary system 

    WASL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for WASL: Wasltm1.1Sbs Wasltm1.1Cgn Wasltm1Sbs

       inGenious Targeting Laboratory - Custom generated mouse model solutions for WASL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WASL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WASL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WASL 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WASL
    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate WASL (see all 74):
    hsa-miR-520f hsa-miR-3146 hsa-miR-15a hsa-miR-374a hsa-miR-3613-3p hsa-miR-3116 hsa-miR-130b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidWASL 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for WASL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WASL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WASL
    Sirion Biotech Customized adenovirus for overexpression of WASL

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for WASL (see all 7)
    OriGene ORF clones in mouse, rat for WASL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WASL (NM_003941)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WASL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WASL
    Sirion Biotech Customized lentivirus for stable overexpression of WASL 
                         Customized lentivirus expression plasmids for stable overexpression of WASL 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for WASL
    Search LifeMap BioReagents cell lines for WASL
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WASL About   (see all 40)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Slit-Robo signaling
    Development Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.43
    Cytoskeleton remodeling Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    2Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.80
    Fcgamma receptor (FCGR) dependent phagocytosis0.80
    3Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    4Metabolism of nitric oxide
    Metabolism of nitric oxide0.59
    eNOS activation and regulation0.59
    5Immune System
    Immune System0.56
    Innate Immune System0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for WASL (see all 7)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling CDC42 in cellular processes
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Cytoskeleton remodeling Slit-Robo signaling

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WASL (see all 9)
        Actin-Based Motility by Rho Family GTPases
    Guidance Cues and Growth Cone Motility
    CDC42 Pathway
    PDGF Pathway
    Signaling by Slit

    1 Cell Signaling Technology (CST) Pathway for WASL
        Cytoskeletal Signaling

    5/7 GeneGo (Thomson Reuters) Pathways for WASL (see all 7)
        Cytoskeleton remodeling Role of PDGFs in cell migration
    Cell adhesion Integrin-mediated cell adhesion and migration
    Development Slit-Robo signaling
    Cytoskeleton remodeling CDC42 in cellular processes
    Cytoskeleton remodeling Reverse signaling by ephrin B

    5/10 BioSystems Pathways for WASL (see all 10)
        EGFR1 Signaling Pathway
    G13 Signaling Pathway
    Pathogenic Escherichia coli infection
    CDC42 signaling events
    ErbB1 downstream signaling

    5/14        Reactome Pathways for WASL (see all 14)
        Nephrin interactions
    Developmental Biology
    eNOS activation and regulation
    Metabolism
    Fcgamma receptor (FCGR) dependent phagocytosis


    5/8         Kegg Pathways  (Kegg details for WASL) (see all 8):
        Chemokine signaling pathway
    Adherens junction
    Fc gamma R-mediated phagocytosis
    Regulation of actin cytoskeleton
    Bacterial invasion of epithelial cells


    WASL for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WASL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/95 Interacting proteins for WASL (O004011, 2, 3 ENSP000002230234) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITSN1Q158112, 3, ENSP000003707194MINT-14607 MINT-14605 MINT-14606 MINT-7302543 MINT-14608 I2D: score=3 STRING: ENSP00000370719
    CRKP461082, 3, ENSP000003005744MINT-72620 MINT-72571 I2D: score=1 STRING: ENSP00000300574
    SNX9Q9Y5X12, 3, ENSP000003760244MINT-7302014 MINT-7302027 I2D: score=1 STRING: ENSP00000376024
    GRB2P629931, 3, ENSP000003390074EBI-957615,EBI-401755 I2D: score=5 STRING: ENSP00000339007
    CTTNQ142472, 3, ENSP000003018434MINT-6541916 I2D: score=3 STRING: ENSP00000301843
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006461protein complex assembly TAS9422512
    GO:0006900membrane budding ISS--
    GO:0006928cellular component movement TAS9422512

    WASL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    WASL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for WASL available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CK 666Arp2/3 inhibitor; inhibits actin polymerization[442633-00-3]
    Latrunculin AInhibitor of actin assembly and polymerization[76343-93-6]
    Cytochalasin DDisrupts actin filament function[22144-77-0]
    JasplakinolideStabilizes F-actin; promotes actin polymerization[102396-24-7]
    Thymosin beta4Potent actin polymerization regulator[77591-33-4]

    10/11 Novoseek inferred chemical compound relationships for WASL gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskostatin 95.1 13 17405146 (2), 15235593 (2), 18667055 (2), 15800060 (1) (see all 8)
    pip2 60.7 8 8895577 (2), 12147689 (2), 11792818 (1), 17302440 (1) (see all 6)
    tyrosine 36.2 19 12431372 (4), 8895577 (2), 17474908 (2), 14676198 (2) (see all 10)
    proline 22.9 3 17229736 (1), 12147689 (1), 10973991 (1)
    phosphoinositide 22.4 4 16949824 (1), 10953003 (1), 11865026 (1)
    phosphatidylinositol 10.5 5 11694514 (2), 11052943 (1), 18923421 (1), 10219243 (1)
    glucose 3.63 2 11694514 (1), 12456725 (1)
    lipid 0 6 17988218 (2), 12477732 (2), 19824478 (1), 17302440 (1)
    latex 0 2 11401525 (1), 12551957 (1)
    adp 0 3 11792818 (2)

    Search CenterWatch for drugs/clinical trials and news about WASL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WASL gene: 
    NM_003941.3  

    Unigene Clusters for WASL:

    Wiskott-Aldrich syndrome-like
    Hs.143728  [show with all ESTs], Hs.731519  [show with all ESTs]
    Unigene Representative Sequences: BX640852, NM_003941
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000223023(uc003vkz.3)

    miRNA
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    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate WASL (see all 74):
    hsa-miR-520f hsa-miR-3146 hsa-miR-15a hsa-miR-374a hsa-miR-3613-3p hsa-miR-3116 hsa-miR-130b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidWASL 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Clone
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    GenScript: all cDNA clones in your preferred vector: WASL (NM_003941)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WASL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WASL
    Sirion Biotech Customized lentivirus for stable overexpression of WASL 
                         Customized lentivirus expression plasmids for stable overexpression of WASL 
    Primer
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    OriGene qPCR primer pairs and template standards for WASL
    OriGene qSTAR qPCR primer pairs in human, mouse for WASL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WASL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WASL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WASL

    Additional mRNA sequence: 

    AK023554.1 AK289795.1 AM295156.1 BC013776.1 BC028602.1 BC052955.1 CR749438.1 D88460.1 

    12 DOTS entries:

    DT.218480  DT.75117246  DT.95268724  DT.100769559  DT.121053298  DT.121053301  DT.121053311  DT.65287633 
    DT.75118576  DT.92421825  DT.100701098  DT.95265999 

    24/159 AceView cDNA sequences (see all 159):

    BU952498 BQ425087 BU951055 CD107134 CB127157 AI653277 CD359638 W73531 
    CB123879 CN484199 AI521769 BQ286524 BU902219 BE504979 BQ269867 AI761685 
    AI620950 BQ717939 BM751087 N34978 CB132489 BE891172 AI969375 AW044456 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WASL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCATAATA
    WASL Expression
    About this image


    See WASL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WASL

    SOURCE GeneReport for Unigene clusters: Hs.143728 Hs.731519
        SABiosciences Expression via Pathway-Focused PCR Arrays including WASL: 
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Cell Motility in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for WASL
    OriGene qSTAR qPCR primer pairs in human, mouse for WASL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WASL
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WASL
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WASL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for WASL gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wasl1 , 5 Wiskott-Aldrich syndrome-like (human)1, 5 90.69(n)1
    96.21(a)1
      6 (11.28 cM)5
    731781  NM_028459.21  NP_082735.21 
     246138055 
    chicken
    (Gallus gallus)
    Aves WASL1 Wiskott-Aldrich syndrome-like 82.94(n)
    91.47(a)
      417750  NM_001199500.1  NP_001186429.1 
    lizard
    (Anolis carolinensis)
    Reptilia WASL6
    Uncharacterized protein
    89(a)
    1 ↔ 1
    5(67388938-67431696)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.23062 Transcribed sequence with weak similarity to protein more 82.06(n)    142012988 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc554782 similar to Wiskott-Aldrich syndrome-like (human) 76.23(n)   394034  BC044180.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta WASp1 CG1520-PA 47.49(n)
    41.63(a)
      43402  NM_143380.3  NP_651637.1 
    worm
    (Caenorhabditis elegans)
    Secernentea wsp-11 Protein WSP-1 48.7(n)
    37.3(a)
      177616  NM_171393.4  NP_741459.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LAS176
    Actin assembly factor, activates the Arp2/3 protei...
    18(a)
    1 → many
    XV(675939-677840)


    ENSEMBL Gene Tree for WASL (if available)
    TreeFam Gene Tree for WASL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WASL gene
    WAS2  
    3 SIMAP similar genes for WASL using alignment to 3 protein entries:     WASL_HUMAN (see all proteins):
    DKFZp779G0847    WASP    WAS

    WASL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1313 SNPs in WASL are shown (see all 1313)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460323401,2
    C--123321559(+) AAAAC-/AGAGTTT 1 -- ds50010--------
    rs1916265551,2
    --123321805(+) GTTTCC/TCAACA 1 -- ds50010--------
    rs1418502261,2
    --123321928(+) CTTCAC/TTATAC 1 -- ds50010--------
    rs7676371,2
    C,F,A,H--123321978(-) TTCATT/GTGTTT 1 -- ds500125Minor allele frequency- G:0.23NA NS EA WA CSA 2421
    rs1455665551,2
    --123321987(+) AAACAC/TATTAT 1 -- ds50010--------
    rs1830833971,2
    --123321997(+) TTTTAC/TTCTAT 1 -- ut310--------
    rs1176752921,2
    C,F--123322036(+) ATGATG/TAATTG 1 -- ut311Minor allele frequency- T:0.03NA 120
    rs1879587861,2
    --123322110(+) TTCAGG/TTGTCT 1 -- ut310--------
    rs118811,2
    C,F--123322188(+) ATCACG/ATAGCA 1 -- ut31 ese34Minor allele frequency- A:0.01MN NA WA 306
    rs743350871,2
    C,F--123322263(+) GGAGAA/CTATAC 1 -- ut311Minor allele frequency- C:0.09WA 118

    HapMap Linkage Disequilibrium report for WASL (123321989 - 123389121 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for WASL: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing WASL
    DNA2.0 Custom Variant and Variant Library Synthesis for WASL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605056    OMIM disorders: --

    11 diseases for WASL:    About MalaCards
    wiskott-aldrich syndrome    shigellosis    eczema    thrombocytopenia
    vaccinia    cystic fibrosis    tuberculosis    esophagitis
    alzheimer's disease    neuronitis    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for WASL:
    Shigellosis     Wiskott-Aldrich syndrome

    WASL for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    9 Novoseek inferred disease relationships for WASL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 95.6 71 11952639 (2), 15085951 (2), 17092940 (2), 11432863 (2) (see all 59)
    scar1 86.1 8 11747816 (6), 14561714 (1), 11029465 (1)
    scar 40.2 7 12872157 (1), 19018480 (1), 10940259 (1), 11747836 (1) (see all 7)
    cancer 1.71 1 17985201 (1)
    shock 0 4 12871950 (2), 15791211 (1), 17535252 (1)
    metastasis 0 4 19373774 (1), 17985201 (1)
    tumors 0 11 17092940 (3), 19373774 (2), 15699051 (1)
    carcinoma 0 7 15084285 (2), 15362118 (1), 18362183 (1)
    cystic fibrosis 0 1 17306384 (1)

    Genetic Association Database (GAD): WASL

    Export disorders for WASL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WASL gene, integrated from 9 sources (see all 237):
    (articles sorted by number of sources associating them with WASL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of N-WASP homologs in human and rat brain. (PubMed id 9322739)1, 2, 3, 9 Fukuoka M....Takenawa T. (1997)
    2. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. (PubMed id 9422512)1, 3, 9 Miki H....Takenawa T. (1998)
    3. The structural basis of actin interaction with multiple WH2/beta- thymosin motif-containing proteins. (PubMed id 16531231)1, 2, 9 Aguda A.H.... Robinson R.C. (2006)
    4. New gene functions in megakaryopoiesis and platelet fo rmation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (2011)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    7. Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility. (PubMed id 10491394)1, 2 Egile C.... Carlier M.-F. (1999)
    8. Neural Wiskott-Aldrich syndrome protein is implicated in the actin- based motility of Shigella flexneri. (PubMed id 9582270)1, 2 Suzuki T.... Sasakawa C. (1998)
    9. Translocation of N-WASP by nuclear localization and export signals into the nucleus modulates expression of HSP90. (PubMed id 12871950)1, 9 Suetsugu S. and Takenawa T. (2003)
    10. Interaction of HSP90 to N-WASP leads to activation and protection from proteasome-dependent degradation. (PubMed id 15791211)1, 9 Park S.J....Takenawa T. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8976 HGNC: 12735 AceView: WASL Ensembl:ENSG00000106299 euGenes: HUgn8976
    ECgene: WASL Kegg: 8976 H-InvDB: WASL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WASL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WASL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WASL gene:
    Search GeneIP for patents involving WASL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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