WASH6P Gene
pseudogene GIFtS: 26
GCID: GC0XP155250
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WAS protein family homolog 6 pseudogene(Previous names: family with sequence similarity 39, member A, chromosomes...)
(Previous symbols: FAM39A, CXYorf1)
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Aliases
for WASH6P gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WAS Protein Family Homolog 6 Pseudogene1 2 | | Family With Sequence Similarity 39, Member A1 | | CXYorf11 2 3 | | WASH2 | | FAM39A1 2 3 | | Protein FAM39A3 | | Chromosomes X And Y Open Reading Frame 11 | | |
Export aliases for WASH6P gene to outside databasesPrevious GC identifers: GC0XP154905 GC00U922822 |
Summaries
for WASH6P gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: WASH6_HUMAN, Q9NQA3Function: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transportintermediates during endosome sorting (By similarity)
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Genomic Views
for WASH6P gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for WASH6P
Other transcription factors
Search SABiosciences Chromatin IP Primers for WASH6P
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WASH6P |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28;Yq12 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28 and Yq12WASH6P Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP155250: view genomic region
(about GC identifiers)
Start:
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155,249,967 bp from pter |
End:
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155,255,375 bp from pter |
Size:
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5,409 bases |
Orientation:
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plus strand |
1 alternative location:
| ChrY+ 59,354,670-59,358,343 |
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Proteins
for WASH6P gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: WASH6_HUMAN, Q9NQA3 (See
protein sequence)Recommended Name: WAS protein family homolog 6 Size: 447 amino acids; 47990 Da
Subunit: Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3),F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P or WASH6P), FAM21 (FAM21A, FAM21B orFAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via WHD1 region) with FAM21C; the interaction is direct (Bysimilarity)
Subcellular location: Early endosome membrane (By similarity). Recycling endosome membrane (By similarity).Note=Localization to the endodome membrane is mediated via its interaction with FAM21 (By similarity)
Miscellaneous: WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy numberreached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949). It istherefore difficult to determine which gene is functional or not. The gene encoding for this protein is located in thepseudoautosomal region 2 (PAR2) of X and Y chromosomes
Sequence caution: Sequence=CAB96818.1; Type=Erroneous gene model prediction;
Secondary accessions: A6NGF1 Q8N305Explore the universe of human proteins at neXtProt for WASH6P: NX_Q9NQA3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NQA3
WASH6P Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000352498 ENSP00000285718
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
WASH6P for ontologies About GeneDecksing
WASH6P Antibody Products:
Assay Products for WASH6P: |
Protein
Domains /
Families
for WASH6P gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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WASH6P for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NQA3ProtoNet protein and cluster: Q9NQA3 UniProtKB/Swiss-Prot: WASH6_HUMAN, Q9NQA3Similarity: Belongs to the WASH1 familySimilarity: Contains 1 WH2 domain |
Function
for WASH6P gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: WASH6_HUMAN, Q9NQA3Function: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transportintermediates during endosome sorting (By similarity)
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
WASH6P for ontologies About GeneDecksing
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Pathways & Interactions
for WASH6P gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WASH6P
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/13 Interacting proteins for WASH6P (ENSP000003524984) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0008150 | biological_process |
ND | -- | | GO:0016197 | endosomal transport |
ISS | -- | | GO:0034314 | Arp2/3 complex-mediated actin nucleation |
ISS | -- | | GO:0042147 | retrograde transport, endosome to Golgi |
ISS | -- |
WASH6P for ontologies About GeneDecksing
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Drugs & Compounds
for WASH6P gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WASH6P
Search CenterWatch for drugs/clinical trials and news about WASH6P 
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Transcripts
for WASH6P gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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17 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000359512(uc004fnw.1) ENST00000476066 ENST00000461007 ENST00000496011
ENST00000469624 ENST00000479401 ENST00000340131 ENST00000492963 ENST00000460206(uc022cip.1)
ENST00000475594 ENST00000482170 ENST00000484415 ENST00000483079 ENST00000496301
ENST00000483286 ENST00000464205 ENST00000285718
GeneLoc Exon Structure
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Expression
for WASH6P gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WASH6P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See WASH6P Protein Expression from SPIRE MOPED and PaxDB SABiosciences Custom PCR Arrays for WASH6P
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat WASH6P | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WASH6P | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WASH6P |
Orthologs
for WASH6P gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for WASH6P gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
WASH16 |
hypothetical protein LOC418145 |
69(a) |
1 → many |
1(62071951-62111156) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
65(a) |
1 → many |
5(11324639-11363796) |
zebrafish
(Danio rerio) |
Actinopterygii |
wash6 |
WAS protein family homolog |
59(a) |
1 → many |
18(5565808-5588950) |
fruit fly
(Drosophila melanogaster) |
Insecta |
wash6 |
washout |
26(a) |
1 → many |
2R(8068145-8069878) |
worm
(Caenorhabditis elegans) |
Secernentea |
ddl-26 |
Daf-16-Dependent Longevity (WT but not daf-16 life... |
21(a) |
1 → many |
II(13542765-13547559) |
Species with no ortholog for WASH6P
ENSEMBL Gene Tree for WASH6P (if available)
TreeFam Gene Tree for WASH6P (if available) |
Paralogs
for WASH6P gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WASH6P gene
- WASH4P2
8 SIMAP similar genes for WASH6P using alignment to 2 protein entries: WASH6_HUMAN (see all proteins):WASH1 WASH2P WASH3P WASH DKFZp686C24272 WASH4P
DKFZp434K1323 FLJ00075
WASH6P for paralogs About GeneDecksing
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Genomic Variants
for WASH6P gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WASH6P |
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Disorders
/ Diseases
for WASH6P gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WASH6P for disorders About GeneDecksing
1  disease for WASH6P: About MalaCardswiskott-aldrich syndrome
Export disorders for WASH6P gene to outside databases
|
Publications
for WASH6P gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WASH6P gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with WASH6P) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human subtelomeric WASH genes encode a new subclass of the WASP family. (PubMed id 18159949)1, 2, 3 Linardopoulou E.V.... Trask B.J. (2007)
- Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region. (PubMed id 10655549)1, 2, 3 Ciccodicola A.... D'Urso M. (2000)
- Complex events in the evolution of the human pseudoautosomal region 2 (PAR2). (PubMed id 12566406)1, 3 Charchar F.J....Graves J.A. (2003)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Functional characterization of Wiskott-Aldrich syndro me protein and scar homolog (WASH), a bi-modular nucleation-promoting factor ab le to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and gamma-tubulin. (PubMed id 20308062)1 Monfregola J....Ursini M.V. (2010)
- WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally relate d complexes. (PubMed id 20498093)1 Jia D....Billadeau D.D. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)2 Beausoleil S.A.... Gygi S.P. (2006)
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External Searches for WASH6P gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing WASH6P gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing WASH6P gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WASH6P gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WASH6P | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for WASH6P gene:
Search GeneIP for patents involving WASH6P
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WASH6P gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WASH6P | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WASH6P | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WASH6P | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WASH6P | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WASH6P | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WASH6P |
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| | | | Search Tocris compounds for WASH6P |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for WASH6P |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat WASH6P |
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