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Aliases for WASH6P Gene

Aliases for WASH6P Gene

  • WAS Protein Family Homolog 6 Pseudogene 2 3 5
  • Family With Sequence Similarity 39, Member A 2 3
  • CXYorf1 3 4
  • FAM39A 3 4
  • Chromosomes X And Y Open Reading Frame 1 2
  • Actin Nucleation Promoting Factor 3
  • Protein FAM39A 4
  • WASH 3

External Ids for WASH6P Gene

Previous HGNC Symbols for WASH6P Gene

  • FAM39A
  • CXYorf1

Previous GeneCards Identifiers for WASH6P Gene

  • GC0XP154905
  • GC00U922822
  • GC0XP155250

Summaries for WASH6P Gene

GeneCards Summary for WASH6P Gene

WASH6P (WAS Protein Family Homolog 6 Pseudogene) is a Pseudogene. Diseases associated with WASH6P include Wiskott-Aldrich Syndrome and Ritscher-Schinzel Syndrome. Gene Ontology (GO) annotations related to this gene include actin binding and alpha-tubulin binding.

UniProtKB/Swiss-Prot for WASH6P Gene

  • May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.

Additional gene information for WASH6P Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WASH6P Gene

Genomics for WASH6P Gene

GeneHancer (GH) Regulatory Elements for WASH6P Gene

Promoters and enhancers for WASH6P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI155025 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 17.3 -993.2 -993169 3.7 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 YY1 ZNF766 ZNF207 FOS SP3 F8 FUNDC2 WASH6P F8A1 SNORA56 SLC10A3 SNORA70 TMLHE-AS1 EMD GAB3
GH0XI155215 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 10.8 -804.0 -803958 3.1 PKNOX1 ATF1 ARNT DMAP1 YY1 POLR2B GLIS2 ZNF143 FOS ATF7 VBP1 F8A1 DKC1 WASH6P SNORA70 ENSG00000224978 RAB39B
GH0XI156026 Enhancer 0.2 Ensembl 0.4 +5.7 5675 0.6 DDX11L16 WASH6P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WASH6P on UCSC Golden Path with GeneCards custom track

Genomic Locations for WASH6P Gene

Genomic Locations for WASH6P Gene
chrX:156,020,826-156,025,710
(GRCh38/hg38)
Size:
4,885 bases
Orientation:
Plus strand
chrX:155,250,491-155,255,375
(GRCh37/hg19)

Genomic View for WASH6P Gene

Genes around WASH6P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WASH6P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WASH6P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WASH6P Gene

Proteins for WASH6P Gene

  • Protein details for WASH6P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQA3-WASH6_HUMAN
    Recommended name:
    WAS protein family homolog 6
    Protein Accession:
    Q9NQA3
    Secondary Accessions:
    • A6NGF1
    • Q8N305

    Protein attributes for WASH6P Gene

    Size:
    447 amino acids
    Molecular mass:
    47990 Da
    Quaternary structure:
    • Interacts (via WHD1 region) with WASHC2C; the interaction is direct (By similarity).
    Miscellaneous:
    • WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949). It is therefore difficult to determine which gene is functional or not. The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.
    SequenceCaution:
    • Sequence=CAB96818.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for WASH6P Gene

Post-translational modifications for WASH6P Gene

No Post-translational modifications

No data available for DME Specific Peptides for WASH6P Gene

Domains & Families for WASH6P Gene

Protein Domains for WASH6P Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WASH6P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQA3

UniProtKB/Swiss-Prot:

WASH6_HUMAN :
  • Belongs to the WASH1 family.
Family:
  • Belongs to the WASH1 family.
genes like me logo Genes that share domains with WASH6P: view

Function for WASH6P Gene

Molecular function for WASH6P Gene

UniProtKB/Swiss-Prot Function:
May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.

Gene Ontology (GO) - Molecular Function for WASH6P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003779 actin binding IEA --
GO:0043014 alpha-tubulin binding ISS --
genes like me logo Genes that share ontologies with WASH6P: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WASH6P Gene

Localization for WASH6P Gene

Subcellular locations from UniProtKB/Swiss-Prot for WASH6P Gene

Early endosome membrane. Recycling endosome membrane. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2. {ECO:0000250 UniProtKB:A8K0Z3}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WASH6P gene
Compartment Confidence
endosome 4
cytoskeleton 3
cytosol 3
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for WASH6P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome ISS --
GO:0005829 cytosol IEA --
GO:0031901 early endosome membrane IEA --
GO:0055037 recycling endosome ISS --
GO:0055038 recycling endosome membrane IEA --
genes like me logo Genes that share ontologies with WASH6P: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WASH6P Gene

Pathways & Interactions for WASH6P Gene

SuperPathways for WASH6P Gene

No Data Available

Interacting Proteins for WASH6P Gene

Gene Ontology (GO) - Biological Process for WASH6P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016197 endosomal transport ISS --
GO:0034314 Arp2/3 complex-mediated actin nucleation ISS --
GO:0042147 retrograde transport, endosome to Golgi ISS --
genes like me logo Genes that share ontologies with WASH6P: view

No data available for Pathways by source and SIGNOR curated interactions for WASH6P Gene

Drugs & Compounds for WASH6P Gene

No Compound Related Data Available

Transcripts for WASH6P Gene

mRNA/cDNA for WASH6P Gene

(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WASH6P Gene

No ASD Table

Relevant External Links for WASH6P Gene

GeneLoc Exon Structure for
WASH6P
ECgene alternative splicing isoforms for
WASH6P

Expression for WASH6P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WASH6P Gene

mRNA expression in normal human tissues for WASH6P Gene

Protein differential expression in normal tissues from HIPED for WASH6P Gene

This gene is overexpressed in Pancreas (12.0), Lung (10.0), Platelet (6.6), and Ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WASH6P Gene



NURSA nuclear receptor signaling pathways regulating expression of WASH6P Gene:

WASH6P

Evidence on tissue expression from TISSUES for WASH6P Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with WASH6P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WASH6P Gene

Orthologs for WASH6P Gene

Evolution for WASH6P Gene

ENSEMBL:
Gene Tree for WASH6P (if available)
TreeFam:
Gene Tree for WASH6P (if available)

No data available for Orthologs for WASH6P Gene

Paralogs for WASH6P Gene

(8) SIMAP similar genes for WASH6P Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WASH6P: view

No data available for Paralogs for WASH6P Gene

Variants for WASH6P Gene

Additional Variant Information for WASH6P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WASH6P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for WASH6P Gene

Disorders for WASH6P Gene

MalaCards: The human disease database

(2) MalaCards diseases for WASH6P Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
wiskott-aldrich syndrome
  • was
ritscher-schinzel syndrome
  • craniocerebellocardiac dysplasia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for WASH6P

genes like me logo Genes that share disorders with WASH6P: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WASH6P Gene

Publications for WASH6P Gene

  1. Human subtelomeric WASH genes encode a new subclass of the WASP family. (PMID: 18159949) Linardopoulou EV … Trask BJ (PLoS genetics 2007) 2 3 4 58
  2. Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region. (PMID: 10655549) Ciccodicola A … D'Urso M (Human molecular genetics 2000) 2 3 4 58
  3. Complex events in the evolution of the human pseudoautosomal region 2 (PAR2). (PMID: 12566406) Charchar FJ … Graves JA (Genome research 2003) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for WASH6P Gene

Sources for WASH6P Gene

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