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Aliases for WASH6P Gene

Aliases for WASH6P Gene

  • WAS Protein Family Homolog 6 Pseudogene 2 3
  • Family With Sequence Similarity 39, Member A 2 3
  • CXYorf1 3 4
  • FAM39A 3 4
  • Chromosomes X And Y Open Reading Frame 1 2
  • Actin Nucleation Promoting Factor 3
  • Protein FAM39A 4
  • WASH 3

External Ids for WASH6P Gene

Previous HGNC Symbols for WASH6P Gene

  • FAM39A
  • CXYorf1

Previous GeneCards Identifiers for WASH6P Gene

  • GC0XP154905
  • GC00U922822
  • GC0XP155250

Summaries for WASH6P Gene

GeneCards Summary for WASH6P Gene

WASH6P (WAS Protein Family Homolog 6 Pseudogene) is a Pseudogene. Diseases associated with WASH6P include wiskott-aldrich syndrome. GO annotations related to this gene include actin binding and alpha-tubulin binding.

UniProtKB/Swiss-Prot for WASH6P Gene

  • May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WASH6P Gene

Genomics for WASH6P Gene

Genomic Location for WASH6P Gene

Chromosome:
X
Start:
156,020,826 bp from pter
End:
156,025,710 bp from pter
Size:
4,885 bases
Orientation:
Plus strand

Genomic View for WASH6P Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for WASH6P Gene

No data available for Regulatory Elements for WASH6P Gene

Proteins for WASH6P Gene

  • Protein details for WASH6P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQA3-WASH6_HUMAN
    Recommended name:
    WAS protein family homolog 6
    Protein Accession:
    Q9NQA3
    Secondary Accessions:
    • A6NGF1
    • Q8N305

    Protein attributes for WASH6P Gene

    Size:
    447 amino acids
    Molecular mass:
    47990 Da
    Quaternary structure:
    • Interacts (via WHD1 region) with FAM21C; the interaction is direct (By similarity).
    Miscellaneous:
    • WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949). It is therefore difficult to determine which gene is functional or not. The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.
    SequenceCaution:
    • Sequence=CAB96818.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for WASH6P Gene

Proteomics data for WASH6P Gene at MOPED

Post-translational modifications for WASH6P Gene

No Post-translational modifications

No data available for DME Specific Peptides for WASH6P Gene

Domains & Families for WASH6P Gene

Protein Domains for WASH6P Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WASH6P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQA3

UniProtKB/Swiss-Prot:

WASH6_HUMAN :
  • Contains 1 WH2 domain.
  • Belongs to the WASH1 family.
Domain:
  • Contains 1 WH2 domain.
Family:
  • Belongs to the WASH1 family.
genes like me logo Genes that share domains with WASH6P: view

Function for WASH6P Gene

Molecular function for WASH6P Gene

UniProtKB/Swiss-Prot Function:
May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.

Gene Ontology (GO) - Molecular Function for WASH6P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003779 actin binding IEA --
GO:0043014 alpha-tubulin binding ISS --
genes like me logo Genes that share ontologies with WASH6P: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WASH6P Gene

Localization for WASH6P Gene

Subcellular locations from UniProtKB/Swiss-Prot for WASH6P Gene

Early endosome membrane. Recycling endosome membrane. Note=Localization to the endosome membrane is mediated via its interaction with FAM21. {ECO:0000250 UniProtKB:A8K0Z3}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WASH6P Gene COMPARTMENTS Subcellular localization image for WASH6P gene
Compartment Confidence
endosome 5
cytoskeleton 3
vacuole 3

Gene Ontology (GO) - Cellular Components for WASH6P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome ISS --
GO:0031901 early endosome membrane IEA --
GO:0055037 recycling endosome ISS --
GO:0055038 recycling endosome membrane IEA --
GO:0071203 WASH complex ISS --
genes like me logo Genes that share ontologies with WASH6P: view

Pathways & Interactions for WASH6P Gene

SuperPathways for WASH6P Gene

No Data Available

Interacting Proteins for WASH6P Gene

Gene Ontology (GO) - Biological Process for WASH6P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016197 endosomal transport ISS --
GO:0034314 Arp2/3 complex-mediated actin nucleation ISS --
GO:0042147 retrograde transport, endosome to Golgi ISS --
genes like me logo Genes that share ontologies with WASH6P: view

No data available for Pathways by source and SIGNOR curated interactions for WASH6P Gene

Drugs & Compounds for WASH6P Gene

No Compound Related Data Available

Transcripts for WASH6P Gene

mRNA/cDNA for WASH6P Gene

(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for WASH6P Gene

No ASD Table

Relevant External Links for WASH6P Gene

GeneLoc Exon Structure for
WASH6P
ECgene alternative splicing isoforms for
WASH6P

Expression for WASH6P Gene

mRNA expression in normal human tissues for WASH6P Gene

mRNA expression in normal human tissues for WASH6P Gene

Protein differential expression in normal tissues from HIPED for WASH6P Gene

This gene is overexpressed in Pancreas (12.0), Lung (10.0), Platelet (6.6), and Ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for WASH6P Gene



genes like me logo Genes that share expression patterns with WASH6P: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for WASH6P Gene

Orthologs for WASH6P Gene

Evolution for WASH6P Gene

ENSEMBL:
Gene Tree for WASH6P (if available)
TreeFam:
Gene Tree for WASH6P (if available)

No data available for Orthologs for WASH6P Gene

Paralogs for WASH6P Gene

(8) SIMAP similar genes for WASH6P Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WASH6P: view

No data available for Paralogs for WASH6P Gene

Variants for WASH6P Gene

Relevant External Links for WASH6P Gene

HapMap Linkage Disequilibrium report
WASH6P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for WASH6P Gene

Disorders for WASH6P Gene

MalaCards: The human disease database

(1) MalaCards diseases for WASH6P Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
wiskott-aldrich syndrome
  • wiskott syndrome
- elite association

Relevant External Links for WASH6P

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WASH6P
genes like me logo Genes that share disorders with WASH6P: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WASH6P Gene

Publications for WASH6P Gene

  1. Human subtelomeric WASH genes encode a new subclass of the WASP family. (PMID: 18159949) Linardopoulou E.V. … Trask B.J. (PLoS Genet. 2007) 2 67
  2. Complex events in the evolution of the human pseudoautosomal region 2 (PAR2). (PMID: 12566406) Charchar F.J. … Graves J.A. (Genome Res. 2003) 2 67
  3. Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region. (PMID: 10655549) Ciccodicola A. … D'Urso M. (Hum. Mol. Genet. 2000) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for WASH6P Gene

Sources for WASH6P Gene

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