WASH4P Gene
protein-coding GIFtS: 21
GCID: GC16M000064
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WAS protein family homolog 4 pseudogene(Previous names: family with sequence similarity 39, member C pseudogene...)
(Previous symbol: FAM39CP)
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Aliases
for WASH4P gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WAS Protein Family Homolog 4 Pseudogene1 2 | | FAM39CP1 2 3 | | FLJ316701 | | Family With Sequence Similarity 39, Member C Pseudogene1 | | CXYorf1P2 | | Protein FAM39CP3 |
Export aliases for WASH4P gene to outside databasesPrevious GC identifer: GC16M000008 |
Summaries
for WASH4P gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: WASH4_HUMAN, A8MWX3Function: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transportintermediates during endosome sorting (By similarity)
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Genomic Views
for WASH4P gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for WASH4P
Other transcription factors
Search SABiosciences Chromatin IP Primers for WASH4P
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WASH4P |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3WASH4P Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M000064: view genomic region
(about GC identifiers)
Start:
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64,043 bp from pter |
End:
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69,452 bp from pter |
Size:
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5,410 bases |
Orientation:
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minus strand |
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Proteins
for WASH4P gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: WASH4_HUMAN, A8MWX3 (See
protein sequence)Recommended Name: Putative WAS protein family homolog 4 Size: 477 amino acids; 51595 Da
Subunit: Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3),F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P or WASH6P), FAM21 (FAM21A, FAM21B orFAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via WHD1 region) with FAM21C; the interaction is direct (Bysimilarity)
Subcellular location: Early endosome membrane (By similarity). Recycling endosome membrane (By similarity).Note=Localization to the endodome membrane is mediated via its interaction with FAM21 (By similarity)
Miscellaneous: WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy numberreached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949). It istherefore difficult to determine which gene is functional or not. The telomeric region of chromosome 9p is paralogousto the pericentromeric regions of chromosome 9 as well as to 2q. Paralogous regions contain 7 transcriptional units.Duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on chromosome 1 and 15. Thechromosome 16 copy seems to be a pseudogene
Caution: Could be the product of a pseudogeneExplore the universe of human proteins at neXtProt for WASH4P: NX_A8MWX3
WASH4P Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000317542 ENSP00000454316 ENSP00000457756 ENSP00000457950 ENSP00000441402
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
WASH4P for ontologies About GeneDecksing
WASH4P Antibody Products:
Assay Products for WASH4P: |
Protein
Domains /
Families
for WASH4P gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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WASH4P for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A8MWX3ProtoNet protein and cluster: A8MWX3 UniProtKB/Swiss-Prot: WASH4_HUMAN, A8MWX3Similarity: Belongs to the WASH1 familySimilarity: Contains 1 WH2 domain |
Function
for WASH4P gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: WASH4_HUMAN, A8MWX3Function: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transportintermediates during endosome sorting (By similarity)
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0003779 | actin binding |
-- | -- | | GO:0043014 | alpha-tubulin binding |
-- | -- |
WASH4P for ontologies About GeneDecksing
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Pathways & Interactions
for WASH4P gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WASH4P
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/12 Interacting proteins for WASH4P (ENSP000003175424) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016197 | endosomal transport |
-- | -- | | GO:0034314 | Arp2/3 complex-mediated actin nucleation |
-- | -- | | GO:0042147 | retrograde transport, endosome to Golgi |
-- | -- |
WASH4P for ontologies About GeneDecksing
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Drugs & Compounds
for WASH4P gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WASH4P
Search CenterWatch for drugs/clinical trials and news about WASH4P / WASH4 
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Transcripts
for WASH4P gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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13 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000326592(uc002cfg.1) ENST00000474799 ENST00000470283 ENST00000468574
ENST00000564273 ENST00000477365 ENST00000495251 ENST00000462860 ENST00000470725
ENST00000487568 ENST00000483390 ENST00000538848 ENST00000494585
24/139 AceView cDNA sequences (see all 139): AA514350 AI683609 AI830275 BQ637147 AA579996 AA707896 BQ888995 CA406456 BV201965 BQ879313 BV201963 AA278412 BQ214648 CA392349 BV185364 AI784591 BG677534 BV201982 CD722548 BV202376 BI833485 AA382059 BV202473 BU738983
GeneLoc Exon Structure
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Expression
for WASH4P gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WASH4P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See WASH4P Protein Expression from SPIRE MOPED and PaxDB SABiosciences Custom PCR Arrays for WASH4P
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat WASH4P | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WASH4P | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WASH4P |
Orthologs
for WASH4P gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for WASH4P gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
WASH16 |
hypothetical protein LOC418145 |
68(a) |
1 → many |
1(62071951-62111156) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
65(a) |
1 → many |
5(11324639-11363796) |
zebrafish
(Danio rerio) |
Actinopterygii |
wash6 |
WAS protein family homolog |
59(a) |
1 → many |
18(5565808-5588950) |
fruit fly
(Drosophila melanogaster) |
Insecta |
wash6 |
washout |
26(a) |
1 → many |
2R(8068145-8069878) |
worm
(Caenorhabditis elegans) |
Secernentea |
ddl-26 |
Daf-16-Dependent Longevity (WT but not daf-16 life... |
21(a) |
1 → many |
II(13542765-13547559) |
ENSEMBL Gene Tree for WASH4P (if available)
TreeFam Gene Tree for WASH4P (if available) |
Paralogs
for WASH4P gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WASH4P gene
- WASH6P2
8 SIMAP similar genes for WASH4P using alignment to 4 protein entries: WASH4_HUMAN (see all proteins):WASH2P WASH WASH1 WASH3P DKFZp686C24272 WASH6P
DKFZp434K1323 FLJ00075
WASH4P for paralogs About GeneDecksing
5/9 Pseudogenes.org Pseudogenes for WASH4P (see all 9)
PGOHUM00000262196 PGOHUM00000262197 PGOHUM00000262200 PGOHUM00000262201 PGOHUM00000262264
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Genomic Variants
for WASH4P gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WASH4P (64043 - 69452 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WASH4P: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for WASH4P gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for WASH4P gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for WASH4P gene integrated from 9 sources:
(articles sorted by number of sources associating them with WASH4P) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human subtelomeric WASH genes encode a new subclass of the WASP family. (PubMed id 18159949)1, 2, 3 Linardopoulou E.V.... Trask B.J. (2007)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
- Characterization of the murine orthologue of a novel human subtelomeric multigene family. (PubMed id 11701968)1, 3 Gianfrancesco F....D'Urso M. (2001)
- The relationship between chromosome structure and function at a human telomeric region. (PubMed id 9054936)1, 3 Flint J.... Higgs D.R. (1997)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region. (PubMed id 10655549)2 Ciccodicola A.... D'Urso M. (2000)
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External Searches for WASH4P gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing WASH4P gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing WASH4P gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WASH4P gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for WASH4P gene:
Search GeneIP for patents involving WASH4P
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for WASH4P gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WASH4P | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WASH4P | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WASH4P | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WASH4P | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WASH4P | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WASH4P |
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| | | | Search Tocris compounds for WASH4P |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for WASH4P |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat WASH4P |
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