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Aliases for WASH4P Gene

Aliases for WASH4P Gene

  • WAS Protein Family Homolog 4 Pseudogene 2 3
  • Family With Sequence Similarity 39, Member C Pseudogene 2 3
  • FAM39CP 3 4
  • Putative WAS Protein Family Homolog 4 3
  • Pseudogene Of CXYorf1 3
  • Protein FAM39CP 4
  • CXYorf1P 3

External Ids for WASH4P Gene

Previous Symbols for WASH4P Gene

  • FAM39CP

Summaries for WASH4P Gene

GeneCards Summary for WASH4P Gene

WASH4P (WAS Protein Family Homolog 4 Pseudogene) is a Pseudogene.

UniProtKB/Swiss-Prot for WASH4P Gene

  • May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WASH4P Gene

Genomics for WASH4P Gene

Genomic Location for WASH4P Gene

Start:
14,043 bp from pter
End:
19,452 bp from pter
Size:
5,410 bases
Orientation:
Minus strand

Genomic View for WASH4P Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WASH4P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WASH4P Gene

No data available for Regulatory Elements for WASH4P Gene

Proteins for WASH4P Gene

  • Protein details for WASH4P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MWX3-WASH4_HUMAN
    Recommended name:
    Putative WAS protein family homolog 4
    Protein Accession:
    A8MWX3
    Secondary Accessions:

    Protein attributes for WASH4P Gene

    Size:
    477 amino acids
    Molecular mass:
    51595 Da
    Quaternary structure:
    • Interacts (via WHD1 region) with FAM21C; the interaction is direct (By similarity).
    Miscellaneous:
    • WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949). It is therefore difficult to determine which gene is functional or not. The telomeric region of chromosome 9p is paralogous to the pericentromeric regions of chromosome 9 as well as to 2q. Paralogous regions contain 7 transcriptional units. Duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on chromosome 1 and 15. The chromosome 16 copy seems to be a pseudogene.

neXtProt entry for WASH4P Gene

Proteomics data for WASH4P Gene at MOPED

Post-translational modifications for WASH4P Gene

No Post-translational modifications

Other Protein References for WASH4P Gene

No data available for DME Specific Peptides for WASH4P Gene

Domains for WASH4P Gene

Gene Families for WASH4P Gene

HGNC:
  • WASH :WAS protein homologs

Protein Domains for WASH4P Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

WASH4_HUMAN
Domain:
  • Contains 1 WH2 domain.:
    • A8MWX3
Family:
  • Belongs to the WASH1 family.:
    • A8MWX3
genes like me logo Genes that share domains with WASH4P: view

Function for WASH4P Gene

Molecular function for WASH4P Gene

UniProtKB/Swiss-Prot Function: May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.

Gene Ontology (GO) - Molecular Function for WASH4P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding --
GO:0043014 alpha-tubulin binding --
genes like me logo Genes that share ontologies with WASH4P: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for WASH4P Gene

Localization for WASH4P Gene

Subcellular locations from UniProtKB/Swiss-Prot for WASH4P Gene

Early endosome membrane. Recycling endosome membrane. Note=Localization to the endosome membrane is mediated via its interaction with FAM21. {ECO:0000250 UniProtKB:A8K0Z3}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WASH4P Gene COMPARTMENTS Subcellular localization image for WASH4P gene
Compartment Confidence
endosome 4
mitochondrion 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for WASH4P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome --
GO:0016020 membrane --
GO:0055037 recycling endosome --
GO:0071203 WASH complex --
genes like me logo Genes that share ontologies with WASH4P: view

Pathways for WASH4P Gene

SuperPathways for WASH4P Gene

No Data Available

Interacting Proteins for WASH4P Gene

Gene Ontology (GO) - Biological Process for WASH4P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016197 endosomal transport --
GO:0034314 Arp2/3 complex-mediated actin nucleation --
GO:0042147 retrograde transport, endosome to Golgi --
genes like me logo Genes that share ontologies with WASH4P: view

No data available for Pathways by source for WASH4P Gene

Transcripts for WASH4P Gene

Alternative Splicing Database (ASD) splice patterns (SP) for WASH4P Gene

No ASD Table

Relevant External Links for WASH4P Gene

GeneLoc Exon Structure for
WASH4P
ECgene alternative splicing isoforms for
WASH4P

Expression for WASH4P Gene

mRNA expression in normal human tissues for WASH4P Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WASH4P Gene

genes like me logo Genes that share expressions with WASH4P: view

Orthologs for WASH4P Gene

This gene was present in the common ancestor of animals.

Orthologs for WASH4P Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WASH4P 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WASH1 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WASH4P 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wash 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WASH4P 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WASH4P 37
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves WASH1 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WASH4P 37
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wash 37
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta wash 37
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2847 37
  • 43 (a)
OneToOne
Species with no ortholog for WASH4P:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WASH4P Gene

ENSEMBL:
Gene Tree for WASH4P (if available)
TreeFam:
Gene Tree for WASH4P (if available)

Paralogs for WASH4P Gene

Selected SIMAP similar genes for WASH4P Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with WASH4P: view

No data available for Paralogs for WASH4P Gene

Variants for WASH4P Gene

Relevant External Links for WASH4P Gene

HapMap Linkage Disequilibrium report
WASH4P

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for WASH4P Gene

Disorders for WASH4P Gene

No disorders were found for WASH4P Gene.

No data available for UniProtKB/Swiss-Prot for WASH4P Gene

Publications for WASH4P Gene

  1. Human subtelomeric WASH genes encode a new subclass of the WASP family. (PMID: 18159949) Linardopoulou E.V. … Trask B.J. (PLoS Genet. 2007) 2 3 4
  2. The relationship between chromosome structure and function at a human telomeric region. (PMID: 9054936) Flint J. … Higgs D.R. (Nat. Genet. 1997) 2 3
  3. Characterization of the murine orthologue of a novel human subtelomeric multigene family. (PMID: 11701968) Gianfrancesco F. … D'Urso M. (Cytogenet. Cell Genet. 2001) 2 3
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for WASH4P Gene

Sources for WASH4P Gene

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