WASH3P Gene
pseudogene GIFtS: 33
GCID: GC15P102501
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WAS protein family homolog 3 pseudogene(Previous names: family with sequence similarity 39, member D pseudogene...)
(Previous symbol: FAM39DP)
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Aliases
for WASH3P gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
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| WAS Protein Family Homolog 3 Pseudogene1 2 | | FAM39DP1 2 3 | | FLJ252221 | | Family With Sequence Similarity 39, Member D Pseudogene1 | | Protein FAM39DP3 |
| External Ids: | HGNC: 243621 | Entrez Gene: 3746662 | Ensembl: ENSG000001855967 | UniProtKB: C4AMC73 | | ORGUL members: | |
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| NONCODE:n406198 n345910 | |
Export aliases for WASH3P gene to outside databasesPrevious GC identifers: GC15P100321 GC15U900980
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Summaries
for WASH3P gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: WASH3_HUMAN, C4AMC7Function: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transportintermediates during endosome sorting (By similarity)
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Genomic Views
for WASH3P gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010274.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WASH3P gene promoter:
FOXF2 MEF-2 POU3F1 E4BP4 MEF-2A POU2F1a POU2F1b aMEF-2 POU2F1c RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for WASH3P
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WASH3P |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q26.3 Ensembl cytogenetic band: 15q26.3 HGNC cytogenetic band: 15q26.3WASH3P Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P102501: view genomic region
(about GC identifiers)
Start:
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102,501,016 bp from pter |
End:
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102,516,808 bp from pter |
Size:
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15,793 bases |
Orientation:
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plus strand |
ORGUL member locations:
Legend (see complete legend)
102501015 102508912 102516808 chr15
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Proteins
for WASH3P gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: WASH3_HUMAN, C4AMC7 (See
protein sequence)Recommended Name: Putative WAS protein family homolog 3 Size: 463 amino acids; 49995 Da
Subunit: Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3),F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P or WASH6P), FAM21 (FAM21A, FAM21B orFAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via WHD1 region) with FAM21C; the interaction is direct (Bysimilarity)
Subcellular location: Early endosome membrane (By similarity). Recycling endosome membrane (By similarity).Note=Localization to the endodome membrane is mediated via its interaction with FAM21 (By similarity)
Miscellaneous: WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy numberreached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949). It istherefore difficult to determine which gene is functional or not. The telomeric region of chromosome 9p is paralogousto the pericentromeric regions of chromosome 9 as well as to 2q. Paralogous regions contain 7 transcriptional units.Duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on chromosome 1 and 15. Thechromosome 16 copy seems to be a pseudogeneExplore the universe of human proteins at neXtProt for WASH3P: NX_C4AMC7
WASH3P Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
WASH3P for ontologies About GeneDecksing
WASH3P Antibody Products:
Assay Products for WASH3P: |
Protein
Domains /
Families
for WASH3P gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WASH3P for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry C4AMC7ProtoNet protein and cluster: C4AMC7 UniProtKB/Swiss-Prot: WASH3_HUMAN, C4AMC7Similarity: Belongs to the WASH1 familySimilarity: Contains 1 WH2 domain |
Function
for WASH3P gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: WASH3_HUMAN, C4AMC7Function: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transportintermediates during endosome sorting (By similarity)
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASH3P |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0003779 | actin binding |
IEA | -- | | GO:0043014 | alpha-tubulin binding |
ISS | -- |
WASH3P for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for WASH3P:
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Pathways & Interactions
for WASH3P gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WASH3P
2 Interacting proteins for WASH3P (C4AMC73) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016197 | endosomal transport |
ISS | -- | | GO:0034314 | Arp2/3 complex-mediated actin nucleation |
IDA | 18159949 | | GO:0042147 | retrograde transport, endosome to Golgi |
ISS | -- |
WASH3P for ontologies About GeneDecksing
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Drugs & Compounds
for WASH3P gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WASH3P
Search CenterWatch for drugs/clinical trials and news about WASH3P 
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Transcripts
for WASH3P gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WASH3P gene: NM_199163.2 Unigene Cluster for WASH3P: WAS protein family homolog 3 pseudogene Hs.459573 [show with all ESTs]Unigene Representative Sequence: AK09258310 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000559884(uc002cdj.3) ENST00000558686 ENST00000559163 ENST00000354296
ENST00000557932 ENST00000558784 ENST00000560956 ENST00000338304(uc021szk.1 uc010utt.1 uc010bpl.1 uc010bpk.1 uc010utu.2)
ENST00000398121(uc002cdi.3 uc010bpo.3 uc002cdq.3 uc002cdr.3)
ENST00000378819
Additional cDNA sequence: AK056232.1 AK092583.1 AK095183.1 AK097269.1 AK290087.1 AK291582.1 AK295256.1 AK300161.1 AK308540.1 AK308566.1 AK308574.1 AK309926.1 AK310139.1 BC048328.1 BC053987.1 BC063470.1 BC063555.1 BC094698.1 BC110991.1 BC110996.1 NR_003659.2 NR_024540.1 24/84 DOTS entries (see all 84): DT.454253 DT.95172025 DT.100851542 DT.95364255 DT.86999703 DT.100848231 DT.121055053 DT.92045715 DT.95172022 DT.65284869 DT.95243425 DT.97860170 DT.100840652 DT.121055064 DT.100653448 DT.100803430 DT.121417481 DT.121475240 DT.100654144 DT.85101946 DT.121184997 DT.121185067 DT.121417477 DT.121456739 9 AceView cDNA sequences: BI830790 BI830792 BV188241 BU570288 BI550667 BE145464 BM691866 BG197266 AI310707
GeneLoc Exon Structure
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Expression
for WASH3P gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WASH3P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGGGACGGC
About this image
Genevestigator expression for WASH3P
SOURCE GeneReport for Unigene cluster: Hs.459573
SABiosciences Custom PCR Arrays for WASH3P
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat WASH3P | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WASH3P | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WASH3P | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASH3P |
Orthologs
for WASH3P gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for WASH3P (if available)
TreeFam Gene Tree for WASH3P (if available) |
Paralogs
for WASH3P gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for WASH3P gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for WASH3P (102501016 - 102516808 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for WASH3P
11 CNVs: 77146 77143 32067 30727 72386 87922 77144 77145 72385 35283 87921 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for WASH3P gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for WASH3P gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WASH3P gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with WASH3P) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human subtelomeric WASH genes encode a new subclass of the WASP family. (PubMed id 18159949)1, 2, 3 Linardopoulou E.V.... Trask B.J. (2007)
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)1, 2 Zody M.C....Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of the murine orthologue of a novel human subtelomeric multigene family. (PubMed id 11701968)1, 3 Gianfrancesco F....D'Urso M. (2001)
- Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region. (PubMed id 10655549)1, 2 Ciccodicola A.... D'Urso M. (2000)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
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External Searches for WASH3P gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing WASH3P gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WASH3P gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WASH3P gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
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About This Section
| Patent Information for WASH3P gene:
Search GeneIP for patents involving WASH3P
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WASH3P gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WASH3P | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WASH3P | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WASH3P | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WASH3P | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WASH3P | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WASH3P |
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 |  |  |  | |
| | | | Search Tocris compounds for WASH3P |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASH3P |
|  |  |  | | | | Search ThermoFisher Antibodies for WASH3P |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat WASH3P |
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GeneCards Homepage -
Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013
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