WASH2P Gene
pseudogene GIFtS: 33
GCID: GC02P114341
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WAS protein family homolog 2 pseudogene(Previous names: family with sequence similarity 39, member B )
(Previous symbol: FAM39B)
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Aliases
for WASH2P gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| WAS Protein Family Homolog 2 Pseudogene1 2 | | FAM39B1 2 3 | | MGC520001 | | Family With Sequence Similarity 39, Member B1 | | CXYorf1-Like Protein On Chromosome 23 | | Protein FAM39B3 |
| External Ids: | HGNC: 331451 | Entrez Gene: 3752602 | Ensembl: ENSG000001465567 | UniProtKB: Q6VEQ53 | | ORGUL members: | |
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| NONCODE:n406569 n345916 n345972 | |
Export aliases for WASH2P gene to outside databasesPrevious GC identifer: GC02P114060
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Summaries
for WASH2P gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: WASH2_HUMAN, Q6VEQ5Function: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transportintermediates during endosome sorting (By similarity)
|
Genomic Views
for WASH2P gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WASH2P gene promoter:
Pbx1a MEF-2 POU3F1 STAT5A HNF-3beta E4BP4 MEF-2A S8 aMEF-2 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for WASH2P
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WASH2P |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q13 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q13WASH2P Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P114341: view genomic region
(about GC identifiers)
Start:
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114,341,230 bp from pter |
End:
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114,356,655 bp from pter |
Size:
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15,426 bases |
Orientation:
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plus strand |
ORGUL member locations:
Legend (see complete legend)
114341229 114348921 114356613 chr2
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Proteins
for WASH2P gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WASH2_HUMAN, Q6VEQ5 (See
protein sequence)Recommended Name: WAS protein family homolog 2 Size: 465 amino acids; 50312 Da
Subunit: Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3),F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P or WASH6P), FAM21 (FAM21A, FAM21B orFAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via WHD1 region) with FAM21C; the interaction is direct (Bysimilarity)
Subcellular location: Early endosome membrane (By similarity). Recycling endosome membrane (By similarity).Note=Localization to the endodome membrane is mediated via its interaction with FAM21 (By similarity)
Miscellaneous: WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy numberreached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949). It istherefore difficult to determine which gene is functional or not. The telomeric region of chromosome 9p is paralogousto the pericentromeric regions of chromosome 9 as well as to 2q. Paralogous regions contain 7 transcriptional units.Duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on chromosome 1 and 15. Thechromosome 16 copy seems to be a pseudogene
Sequence caution: Sequence=AL078621; Type=Erroneous termination; Positions=25; Note=Translated as Arg;Sequence=AL078621; Type=Erroneous termination; Positions=180; Note=Translated as Glu;Explore the universe of human proteins at neXtProt for WASH2P: NX_Q6VEQ5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6VEQ5
WASH2P Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
WASH2P Antibody Products:
Assay Products for WASH2P: |
Protein
Domains /
Families
for WASH2P gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WASH2P for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6VEQ5ProtoNet protein and cluster: Q6VEQ5 1 Blocks protein family: IPB003124 Actin-binding WH2
UniProtKB/Swiss-Prot: WASH2_HUMAN, Q6VEQ5Similarity: Belongs to the WASH1 familySimilarity: Contains 1 WH2 domain |
Function
for WASH2P gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: WASH2_HUMAN, Q6VEQ5Function: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transportintermediates during endosome sorting (By similarity)
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASH2P |
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Pathways & Interactions
for WASH2P gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WASH2P
2 Interacting proteins for WASH2P (Q6VEQ52, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for WASH2P gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WASH2P
Search CenterWatch for drugs/clinical trials and news about WASH2P 
|
Transcripts
for WASH2P gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WASH2P gene: NM_198943.1 Unigene Clusters for WASH2P: WAS protein family homolog 2 pseudogene Hs.446466 [show with all ESTs], Hs.709408 [show with all ESTs]Unigene Representative Sequences: AK292759, BC0638934 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000453662 ENST00000326632(uc010fkx.1 uc002tka.3 uc002tkd.3 uc002tkh.3)
ENST00000538033(uc010fkz.1 uc002tkf.2) ENST00000542901(uc002tke.1)
Additional cDNA sequence: AK289708.1 AK296182.1 AK302089.1 AY217347.1 AY341936.1 AY341937.1 BC014406.1 BC015400.1 BC041177.1 BC063459.1 BC063893.1 BC064371.1 BC073149.1 BC100279.1 BC106020.1 BX537637.1 NR_024077.2 24/67 DOTS entries (see all 67): DT.92460094 DT.95126574 DT.100864588 DT.100848231 DT.100641128 DT.454253 DT.95243425 DT.95172025 DT.107395 DT.120654009 DT.121302921 DT.100851542 DT.121020052 DT.100059382 DT.120654001 DT.100653448 DT.100829692 DT.100803430 DT.121020043 DT.95172022 DT.97768357 DT.100059380 DT.120653989 DT.121020035 24/287 AceView cDNA sequences (see all 287): BM977707 BI768939 CR610039 AY341936 CB266858 BC082240 BM546593 AI571605 F10620 AI207037 BV202282 AL539403 BU171764 BI753043 BI759058 BQ933504 BI763839 BV174799 BV201955 BV202491 BM928610 BV201949 CD107763 AA278412
GeneLoc Exon Structure
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Expression
for WASH2P gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WASH2P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for WASH2P
SOURCE GeneReport for Unigene clusters: Hs.446466 Hs.709408
SABiosciences Custom PCR Arrays for WASH2P
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WASH2P
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat WASH2P | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WASH2P | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WASH2P | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASH2P |
Orthologs
for WASH2P gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of human and mouse.
Orthologs for WASH2P gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Wash5 |
open reading frame 19 |
-- |
|
17 (35.26 cM) 66111546 |
ENSEMBL Gene Tree for WASH2P (if available)
TreeFam Gene Tree for WASH2P (if available) |
Paralogs
for WASH2P gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for WASH2P gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WASH2P (114341230 - 114356655 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for WASH2P
5 CNVs: 74220 89901 89903 31000 3386 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for WASH2P gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for WASH2P gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WASH2P gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with WASH2P) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human subtelomeric WASH genes encode a new subclass of the WASP family. (PubMed id 18159949)1, 2, 3 Linardopoulou E.V.... Trask B.J. (2007)
- Diverse fates of paralogs following segmental duplication of telomeric genes. (PubMed id 15233989)1, 2 Wong A....Ledbetter D.H. (2004)
- Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region. (PubMed id 10655549)1, 2 Ciccodicola A.... D'Urso M. (2000)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for WASH2P gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing WASH2P gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WASH2P gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WASH2P gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for WASH2P gene:
Search GeneIP for patents involving WASH2P
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WASH2P gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WASH2P | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WASH2P | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WASH2P | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | Browse 3'-UTR reporter clones for miRNA target validation | | | Browse OriGene untagged cDNA clones in CMV expression vector | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WASH2P | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for WASH2P | | OriGene Custom Protein Services for WASH2P | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WASH2P | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WASH2P | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WASH2P | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WASH2P | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WASH2P | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WASH2P |
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 |  |  |  | |
| | | | Search Tocris compounds for WASH2P |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASH2P |
|  |  |  | | | | Search ThermoFisher Antibodies for WASH2P |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat WASH2P |
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Last full update: 19 Mar 2013 -
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