V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

WASH1 Gene

protein-coding   GIFtS: 28

GC09M000008
WAS protein family homolog 1
(Previous names: family with sequence similarity 39, member E )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: FAM39E)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
FAM39E 2, 3
FLJ00038 1, 2
FLJ75027 2
FLJ99609 2
Descriptions
CXYorf1-like protein on chromosome 2 3
Protein FAM39E 3
WAS protein family homolog 1 2
family with sequence similarity 39, member E 1, 2
External Ids
HGNC: 243611
Entrez Gene: 3756902
UniProtKB: A8K0Z33
Ensembl: ENSG000001855967
Search outside databases for aliases for WASH1 gene

Previous GC identifer: GC0YP057765

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 9p24.3

WASH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M000008:     (about GC identifiers)

Start:
4,517 bp from pter
End:
7,479 bp from pter
Size:
2,963 bases
Orientation:
minus strand

1 alternative location:
Chr15+ 100,319,118-100,334,282     
RefSeq DNA sequence:
NC_000009.10  NT_008413.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: WASH1_HUMAN, A8K0Z3 (See protein sequence)
Recommended Name: WAS protein family homolog 1  
Size: 468 amino acids; 50522 Da
Miscellaneous: The telomeric region of chromosome 9p is paralogous to the pericentromeric regions
of chromosome 9 as well as to 2q. Paralogous regions contain 7 transcriptional units, including
CXYorf1. Duplicated CXYorf1 genes are also present in the Xq/Yq pseudoautosomal region, as well as
on chromosome 1 and 15. The chromosome 16 copy seems to be a pseudogene

REFSEQ proteins: NP_878908.3  

ENSEMBL proteins: 
ENSP00000344022 ENSP00000346250 ENSP00000375533 ENSP00000368096 ENSP00000381189 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for WASH1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for WASH1
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for WASH1

Assays for WASH1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro domain/family:
 IPR003124 WH2_actin_bd


   GeneDecks  WASH1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry A8K0Z3

ProtoNet protein and cluster: A8K0Z3

UniProtKB/Swiss-Prot: WASH1_HUMAN, A8K0Z3
Similarity: Belongs to the FAM39 family
Similarity: Contains 1 WH2 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 94): XM_926088

              Applied Biosystems Silencer® siRNAs for WASH1

              Sigma-Aldrich siRNA for WASH1  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_182905
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_182905
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_182905 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_182905

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003779 actin binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WASH1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 94): XM_926088

              Sigma-Aldrich siRNA for WASH1  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_182905  

REFSEQ mRNAs for WASH1 gene: 

NM_182905.3   


              OriGene GFP tagged cDNA clone in CMV expression vector: NM_182905
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_182905
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_182905 

Additional cDNA sequence: 

AK024481.1 AK311358.1 DQ786201.1 DQ786314.1 

24/113 DOTS entries (see all 113 ):

DT.92460094  DT.95126574  DT.92045715  DT.121417451  DT.100059382  DT.100829692  DT.120654001  DT.40265813 
DT.85101945  DT.95172025  DT.121055053  DT.120654009  DT.121302921  DT.95333413  DT.70104820  DT.86999703 
DT.97857002  DT.100654144  DT.454253  DT.97771681  DT.121184985  DT.121417411  DT.92460090  DT.100059380 

Unigene Clusters for WASH1:

WAS protein family homolog 1
Hs.446466  [show with all ESTs], Hs.461200  [show with all ESTs]
Unigene Representative Sequences: XM_377073, AK024481


GeneLoc Exon Structure

5 Ensembl transcripts including schematic representations:
ENST00000338304  ENST00000354296  ENST00000391654  ENST00000378819  ENST00000398121  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WASH1 expression in normal and diseased human tissues

1 / 2

11 probe-sets matching WASH1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

65766_at2 U95-C 9 1.00 0.14 0.74 1.32 -- -- -- -- --
54175_at2 U95-C 2 0.88 0.50 0.88 0.68 -- -- -- -- --

225995_x_at2 U133-B 9 1.00 0.13 -- -- -- -- -- -- --

233929_x_at2 U133-B 9 1.00 0.13 -- -- -- -- -- -- --

225035_x_at2 U133-B 9 1.00 0.12 -- -- -- -- -- -- --

226340_x_at2 U133-B 9 0.82 0.10 -- -- -- -- -- -- --

225995_x_at2 U133Plus2 9 1.00 0.13 -- -- -- -- -- -- --

233929_x_at2 U133Plus2 9 1.00 0.13 -- -- -- -- -- -- --

225035_x_at2 U133Plus2 9 1.00 0.12 -- -- -- -- -- -- --

226340_x_at2 U133Plus2 9 0.82 0.10 -- -- -- -- -- -- --

1557034_s_at2 U133Plus2 2 0.46 0.50 -- -- -- -- -- -- --
GeneDecks  WASH1 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.446466 Hs.461200
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

ENSEMBL Gene Tree for WASH1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for WASH1 gene
WASH4P2  ENSG000001553522  ENSG000001824842  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

  --
(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

8 PubMed articles for WASH1 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 375690 HGNC: 24361 Ensembl:ENSG00000185596 euGenes: HUgn375690 ECgene: WASH1
H-InvDB: WASH1
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for WASH1:
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for WASH1-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for WASH1 Antibodies for WASH1
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
 Flow Cytometry Kits   Protease Activity Assays & Reagents  
 Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
 Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
 Recombinant & Natural Proteins  

 Search for Recombinant Proteins
 Search for Antibodies
 Search for Chimera RNAi
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Search for Recombinant Proteins
 Search for Antibodies
 Search OriGene for WASH1
 Search Tocris compounds for WASH1




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for WASH1

GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

Random Gene From GIFtS : about GIFtS

Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science



The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
WASH1 Gene at Home site.
Version 2.41.1
server4.xennexinc.com