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WASH1 Gene

protein-coding   GIFtS: 40
GCID: GC09M000018

WAS Protein Family Homolog 1

(Previous names: family with sequence similarity 39, member E)
(Previous symbol: FAM39E)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WAS Protein Family Homolog 11 2     WASH2 5
FAM39E1 2 3     FLJ00075 Protein2
Family With Sequence Similarity 39, Member E1 2     Protein FAM39E3
CXYorf1-Like Protein On Chromosome 92 3     

External Ids:    HGNC: 243611   Entrez Gene: 1002871712   Ensembl: ENSG000001814047   OMIM: 6136325   UniProtKB: A8K0Z33   

Export aliases for WASH1 gene to outside databases

Previous GC identifers: GC0YP057765 GC09M000008


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for WASH1 Gene:
WASH1 (WAS protein family homolog 1) is a protein-coding gene. Diseases associated with WASH1 include wiskott-aldrich syndrome, and paraplegia. GO annotations related to this gene include actin binding and alpha-tubulin binding.

UniProtKB/Swiss-Prot: WASH1_HUMAN, A8K0Z3
Function: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the
Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as
transport intermediates during endosome sorting




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the WASH1 gene promoter:
         MEF-2   POU3F1   E4BP4   MEF-2A   POU2F1   POU2F1a   POU2F1b   POU2F1c   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWASH1 promoter sequence
   Search Chromatin IP Primers for WASH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WASH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.3   Ensembl cytogenetic band:  9p24.3   HGNC cytogenetic band: 9p24.3

WASH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WASH1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M000018:  view genomic region     (about GC identifiers)

Start:
14,511 bp from pter      End:
29,739 bp from pter
Size:
15,229 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WASH1_HUMAN, A8K0Z3 (See protein sequence)
Recommended Name: WAS protein family homolog 1  
Size: 465 amino acids; 50328 Da
Subunit: Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or
CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P or WASH6P), FAM21
(FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via WHD1 region) with FAM21C; the
interaction is direct. Interacts with alpha-tubulin
Miscellaneous: WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy
number reached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949).
It is therefore difficult to determine which gene is functional or not. The telomeric region of chromosome 9p is
paralogous to the pericentromeric regions of chromosome 9 as well as to 2q. Paralogous regions contain 7
transcriptional units. Duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on
chromosome 1 and 15. The chromosome 16 copy seems to be a pseudogene

Explore the universe of human proteins at neXtProt for WASH1: NX_A8K0Z3

Explore proteomics data for WASH1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WASH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_878908.4  

    WASH1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Antibodies for WASH1
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    WASH1 Assay Products:

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    Cloud-Clone Corp. CLIAs for WASH1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WASH: WAS protein homologs

    2 InterPro protein domains:
     IPR028290 WASH1
     IPR021854 WASH1_WAHD

    Graphical View of Domain Structure for InterPro Entry A8K0Z3

    ProtoNet protein and cluster: A8K0Z3

    UniProtKB/Swiss-Prot: WASH1_HUMAN, A8K0Z3
    Similarity: Belongs to the WASH1 family
    Similarity: Contains 1 WH2 domain


    WASH1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WASH1_HUMAN, A8K0Z3
    Function: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the
    Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as
    transport intermediates during endosome sorting

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI19922874
    GO:0043014alpha-tubulin binding IDA19922874
         
    WASH1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WASH1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WASH1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WASH1

    miRNA
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    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WASH1_HUMAN, A8K0Z3: Early endosome membrane. Recycling endosome membrane (By similarity). Note=Localization to
    the endodome membrane is mediated via its interaction with FAM21
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytoskeleton2
    cytosol2
    nucleus2
    golgi apparatus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome ISS--
    GO:0031901early endosome membrane IEA--
    GO:0055037recycling endosome ISS--
    GO:0055038recycling endosome membrane IEA--
    GO:0071203WASH complex IDA19922875

    WASH1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WASH1
    Interactions:

        Search GeneGlobe Interaction Network for WASH1

    4 Interacting proteins for WASH1 (A8K0Z31, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KIAA0196Q127683I2D: score=1 
    KIAA1033Q2M3893I2D: score=1 
    EXOC1Q9NV701EBI-6160405,EBI-1045313
    EXOC8Q8IYI61EBI-6160405,EBI-742102
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016197endosomal transport ISS--
    GO:0034314Arp2/3 complex-mediated actin nucleation ISS--
    GO:0042147retrograde transport, endosome to Golgi IMP19922874

    WASH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WASH1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WASH1 gene: 
    NM_182905.4  

    Unigene Clusters for WASH1:

    WAS protein family homolog 1
    Hs.461200  [show with all ESTs], Hs.585931  [show with all ESTs]
    Unigene Representative Sequences: AK024481, AK057951
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000442926 ENST00000442898(uc011llq.1 uc010mgp.1 uc022bcs.1 uc010mgm.1)
    ENST00000330546 ENST00000399972(uc003zfu.1)
    miRNA
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat WASH1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat WASH1
      QuantiFast Probe-based Assays in human, mouse, rat WASH1

    Additional mRNA sequence: 

    AK057951.1 AK310121.1 BC047449.1 BC063682.1 BC094860.1 DQ786314.1 NR_028269.1 

    Selected DOTS entries (see all 110):

    DT.95172025  DT.92045715  DT.100829692  DT.40265813  DT.121055053  DT.85101945  DT.454253  DT.100059382 
    DT.120654001  DT.121417451  DT.100654144  DT.70104820  DT.86999703  DT.92460094  DT.95126574  DT.95333413 
    DT.100059380  DT.40238106  DT.97857002  DT.100639711  DT.100798951  DT.100848229  DT.100803430  DT.85101946 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WASH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    WASH1 Expression
    About this image


    WASH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hindlimb Dorsal Muscle
    WASH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WASH1 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.461200 Hs.585931
        Custom PCR Arrays for WASH1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WASH1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wash1 WAS protein family homolog 80.75(n)
    82.11(a)
      68767  NM_001037757.1  NP_001032846.1 
    chicken
    (Gallus gallus)
    Aves WASH11 WAS protein family homolog 1 72.9(n)
    76.56(a)
      418145  NM_001006245.1  NP_001006245.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wash11 WAS protein family homolog 1 67.26(n)
    71.08(a)
      549608  NM_001016854.2  NP_001016854.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wash1 WAS protein family homolog 67.17(n)
    66.59(a)
      555174  NM_001110450.1  NP_001103920.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wash1 washout 42.69(n)
    33.58(a)
      36311  NM_136895.3  NP_610739.1 


    ENSEMBL Gene Tree for WASH1 (if available)
    TreeFam Gene Tree for WASH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WASH1 gene
    8 SIMAP similar genes for WASH1 using alignment to 1 protein entry:     WASH1_HUMAN:
    WASH6P    WASH2P    WASH3P    WASH    WASH4P    DKFZp686C24272
    DKFZp434K1323    FLJ00075

    WASH1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WASH1 (see all 81)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2003676261,2
    C--4173(+) GACCCC/TGTGTC 5 -- ds50010--------
    rs2006330701,2
    C--4277(+) AAACAA/GGTCAG 5 -- ds50010--------
    rs1493055631,2
    C--4546(+) CTTCCA/GCTCCT 5 -- ut310--------
    rs625301461,2
    C--4571(+) ACACAG/CTGCTG 5 -- ut311Minor allele frequency- C:0.50NA 2
    rs1996684631,2
    F--4645(+) AGCAAC/TGGCCC 5 -- ut311Minor allele frequency- T:0.37EU 107
    rs2005819221,2
    F--4669(+) GGGGGG/AAAGGT 5 -- ut311Minor allele frequency- A:0.01EU 423
    rs715099221,2
    C,F--4691(+) CCCTAC/GGATTC 10 S syn14Minor allele frequency- G:0.25NA WA EU 111
    rs2003778211,2
    C,F--4697(+) GATTCC/GCAGTC 10 C W mis11Minor allele frequency- G:0.04EU 529
    rs715099231,2
    C,F--4744(+) CGGCAA/C/GAGGAG 15 L V syn1 mis12NA EU 220
    rs1411566621,2
    C,F--5764(+) CCTCCA/GACCGC 5 -- int11Minor allele frequency- G:0.31EU 181

    HapMap Linkage Disequilibrium report for WASH1 (14511 - 29739 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for WASH1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1391017CNV Deletion17803354
    esv1199599CNV Deletion17803354
    nsv471464CNV Duplication19718026
    esv989554CNV Insertion20482838
    nsv891939CNV Loss21882294
    nsv482128CNV Gain20164927
    esv23366CNV Gain+Loss19812545
    nsv8400CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing WASH1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613632    OMIM disorders: --

    5 diseases for WASH1:    
    About MalaCards
    wiskott-aldrich syndrome    paraplegia    spasticity    malaria
    cervicitis

    1 disease from the University of Copenhagen DISEASES database for WASH1:
    Wiskott-Aldrich syndrome

    WASH1 for disorders           About GeneDecksing


    Export disorders for WASH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WASH1 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with WASH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human subtelomeric WASH genes encode a new subclass of the WASP family. (PubMed id 18159949)1, 2, 3 Linardopoulou E.V.... Trask B.J. (PLoS Genet. 2007)
    2. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. (PubMed id 19922875)1, 2 Derivery E.... Gautreau A. (Dev. Cell 2009)
    3. A FAM21-containing WASH complex regulates retromer-dependent sorting. (PubMed id 19922874)1, 2 Gomez T.S. and Billadeau D.D. (Dev. Cell 2009)
    4. Diverse fates of paralogs following segmental duplication of telomeric genes. (PubMed id 15233989)1, 3 Wong A.... Ledbetter D.H. (Genomics 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region. (PubMed id 10655549)1, 2 Ciccodicola A.... D'Urso M. (Hum. Mol. Genet. 2000)
    7. Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. (PubMed id 23452853)1 Hao Y.H....Potts P.R. (Cell 2013)
    8. WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. (PubMed id 23974797)1 Xia P....Fan Z. (EMBO J. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer. (PubMed id 22513087)1 Jia D....Rosen M.K. (Mol. Biol. Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100287171 HGNC: 24361 Ensembl:ENSG00000181404 euGenes: HUgn100287171 ECgene: WASH1
    H-InvDB: WASH1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WASH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WASH1 gene:
    Search GeneIP for patents involving WASH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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