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Aliases &
Descriptions
for WASF4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| | | Descriptions |
|---|
| WAS protein family, member 4 2 | | WASP family protein member 4 3 |
|
| |
Search outside databases for aliases for WASF4 gene |
Summaries
for WASF4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for WASF4:
This gene is a pseudogene belonging to the family of genes encoding Wiskott-Aldrich syndrome (WAS)
proteins, which are involved in the transmission of signals to the actin cytoskeleton.
Wiskott-Aldrich syndrome is a disease of the immune system. This pseudogene, which is apparently
not transcribed, most closely resembles the gene encoding the WAS protein family member 2, which
is located on chromosome 1. [provided by RefSeq]
UniProtKB/Swiss-Prot: WASF4_HUMAN, Q8IV90Function: Downstream effector molecules involved in the transmission of signals from tyrosine
kinase receptors and small GTPases to the actin cytoskeleton (By similarity) |
Genomic Location
for WASF4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23WASF4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP047544:
(about GC identifiers)
Start:
|
47,541,297 bp from pter |
End:
|
47,549,521 bp from pter |
Size:
|
8,225 bases |
Orientation:
|
plus strand |
| Proteins
for WASF4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: WASF4_HUMAN, Q8IV90 (See
protein sequence)Recommended Name: Wiskott-Aldrich syndrome protein family member 4 Size: 625 amino acids; 68189 Da
Subunit: Binds actin and the Arp2/3 complex (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (By similarity)REFSEQ proteins: NP_001096074.1
ENSEMBL proteins: ENSP00000341085
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
Antibodies for WASF4:
Assays for WASF4: | Protein
Domains/
Families
for WASF4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8IV90
ProtoNet protein and cluster: Q8IV90 1 Blocks protein family: IPB003124 Actin-binding WH2
UniProtKB/Swiss-Prot: WASF4_HUMAN, Q8IV90Domain: Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology
(VPH) domainSimilarity: Belongs to the SCAR/WAVE familySimilarity: Contains 1 WH2 domain | Gene Function
for WASF4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| Browse Origene for 29mer shRNA kit in GFP-retroviral vector
 Sigma-Aldrich siRNA for WASF4
Browse shRNA at Sigma-Aldrich
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_001102604
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001102604
untagged cDNA clone in CMV expression vector: NM_001102604
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_001102604
UniProtKB/Swiss-Prot: WASF4_HUMAN, Q8IV90Function: Downstream effector molecules involved in the transmission of signals from tyrosine
kinase receptors and small GTPases to the actin cytoskeleton (By similarity) | Pathways & Interactions
for WASF4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
-- |
Drugs & Compounds
for WASF4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for WASF4
|
Transcripts
for WASF4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene)
About This Section
| Browse Origene for 29mer shRNA kit in GFP-retroviral vector
Sigma-Aldrich siRNA for WASF4
Browse shRNA at Sigma-Aldrich
Explore Sigma-Aldrich super-pooled esiRNAs
REFSEQ mRNAs for WASF4 gene: NM_001102604.1
OriGene GFP tagged cDNA clone in CMV expression vector: NM_001102604
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001102604
untagged cDNA clone in CMV expression vector: NM_001102604
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000338709
|
Expression
for WASF4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| WASF4 expression in normal and diseased human tissues
1 / 2 3 probe-sets matching WASF4 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
|
Orthologs
for WASF4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
| ENSEMBL Gene Tree for WASF4 | Paralogs
for WASF4(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for WASF4 gene
- WASF21 2 WASF32 WASF12
|
SNPs/Variants
for WASF4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for WASF4 (up to first 250kb)
|
Disorders & Mutations
for WASF4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News
for WASF4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for WASF4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| -- |
Search for WASF4
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WASF4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing WASF4
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WASF4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for WASF4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for WASF4:
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