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Aliases for WASF3 Gene

Aliases for WASF3 Gene

  • WAS Protein Family, Member 3 2 3
  • SCAR3 3 4 6
  • WAVE3 3 4 6
  • Verprolin Homology Domain-Containing Protein 3 3 4
  • Protein WAVE-3 3 4
  • Wiskott-Aldrich Syndrome Protein Family Member 3 3
  • WASP Family Verprolin-Homologous Protein 3 3
  • WASP Family Protein Member 3 4
  • KIAA0900 4
  • Brush-1 3

External Ids for WASF3 Gene

Summaries for WASF3 Gene

Entrez Gene Summary for WASF3 Gene

  • This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014]

GeneCards Summary for WASF3 Gene

WASF3 (WAS Protein Family, Member 3) is a Protein Coding gene. Diseases associated with WASF3 include wiskott-aldrich syndrome and ganglioneuroblastoma. Among its related pathways are ERK Signaling and Fcgamma receptor (FCGR) dependent phagocytosis. GO annotations related to this gene include actin binding. An important paralog of this gene is WASF1.

UniProtKB/Swiss-Prot for WASF3 Gene

  • Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Gene Wiki entry for WASF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WASF3 Gene

Genomics for WASF3 Gene

Genomic Location for WASF3 Gene

Start:
26,557,703 bp from pter
End:
26,688,948 bp from pter
Size:
131,246 bases
Orientation:
Plus strand

Genomic View for WASF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WASF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WASF3 Gene

No data available for Regulatory Elements for WASF3 Gene

Proteins for WASF3 Gene

  • Protein details for WASF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPY6-WASF3_HUMAN
    Recommended name:
    Wiskott-Aldrich syndrome protein family member 3
    Protein Accession:
    Q9UPY6
    Secondary Accessions:
    • O94974
    • Q86VQ2

    Protein attributes for WASF3 Gene

    Size:
    502 amino acids
    Molecular mass:
    55293 Da
    Quaternary structure:
    • Binds actin and the Arp2/3 complex
    SequenceCaution:
    • Sequence=BAA74923.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WASF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WASF3 Gene

Proteomics data for WASF3 Gene at MOPED

Post-translational modifications for WASF3 Gene

  • Phosphorylation by ABL1 promotes lamellipodia formation and cell migration.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WASF3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for WASF3 Gene

Domains for WASF3 Gene

Protein Domains for WASF3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

WASF3_HUMAN
Domain:
  • Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain:
    • Q9UPY6
  • Contains 1 WH2 domain.:
    • Q9UPY6
Family:
  • Belongs to the SCAR/WAVE family.:
    • Q9UPY6
genes like me logo Genes that share domains with WASF3: view

No data available for Gene Families for WASF3 Gene

Function for WASF3 Gene

Molecular function for WASF3 Gene

GENATLAS Biochemistry: WAS protein family,member 3,widely expressed,strongly in brain,associating with the Arp2/3 complex a nucleating core for actin polymerization in vitro
UniProtKB/Swiss-Prot Function: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Gene Ontology (GO) - Molecular Function for WASF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with WASF3: view

Phenotypes for WASF3 Gene

genes like me logo Genes that share phenotypes with WASF3: view

Animal Models for WASF3 Gene

MGI Knock Outs for WASF3:

miRNA for WASF3 Gene

miRTarBase miRNAs that target WASF3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WASF3 Gene

Localization for WASF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WASF3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WASF3 Gene COMPARTMENTS Subcellular localization image for WASF3 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for WASF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0030027 lamellipodium IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with WASF3: view

Pathways for WASF3 Gene

genes like me logo Genes that share pathways with WASF3: view

Pathways by source for WASF3 Gene

1 Qiagen pathway for WASF3 Gene
1 Cell Signaling Technology pathway for WASF3 Gene

Gene Ontology (GO) - Biological Process for WASF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly TAS 10381382
GO:0007010 cytoskeleton organization IMP 21834987
GO:0008360 regulation of cell shape IMP 21834987
GO:0014003 oligodendrocyte development IEA --
GO:0030032 lamellipodium assembly IEA --
genes like me logo Genes that share ontologies with WASF3: view

Transcripts for WASF3 Gene

Unigene Clusters for WASF3 Gene

WAS protein family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WASF3 Gene

No ASD Table

Relevant External Links for WASF3 Gene

GeneLoc Exon Structure for
WASF3
ECgene alternative splicing isoforms for
WASF3

Expression for WASF3 Gene

mRNA expression in normal human tissues for WASF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WASF3 Gene

SOURCE GeneReport for Unigene cluster for WASF3 Gene Hs.618732

mRNA Expression by UniProt/SwissProt for WASF3 Gene

Q9UPY6-WASF3_HUMAN
Tissue specificity: Expressed in ovary and brain
genes like me logo Genes that share expressions with WASF3: view

Orthologs for WASF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for WASF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WASF3 36
  • 99.47 (n)
  • 99.8 (a)
WASF3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WASF3 36
  • 86.09 (n)
  • 94.01 (a)
WASF3 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WASF3 36
  • 89.97 (n)
  • 96.22 (a)
WASF3 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wasf3 36
  • 85.36 (n)
  • 92.81 (a)
Wasf3 16
Wasf3 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WASF3 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WASF3 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wasf3 36
  • 79.84 (n)
  • 85.03 (a)
chicken
(Gallus gallus)
Aves WASF3 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WASF3 37
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wasf3 36
  • 72.19 (n)
  • 77.78 (a)
zebrafish
(Danio rerio)
Actinopterygii wasf3 36
  • 65.52 (n)
  • 71.03 (a)
wasf3 37
  • 67 (a)
OneToMany
WASF3 (1 of 2) 37
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta SCAR 37
  • 31 (a)
OneToMany
SCAR 38
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea wve-1 37
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2335 37
  • 42 (a)
OneToMany
Species with no ortholog for WASF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WASF3 Gene

ENSEMBL:
Gene Tree for WASF3 (if available)
TreeFam:
Gene Tree for WASF3 (if available)

Paralogs for WASF3 Gene

Paralogs for WASF3 Gene

Selected SIMAP similar genes for WASF3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WASF3: view

Variants for WASF3 Gene

Sequence variations from dbSNP and Humsavar for WASF3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs10159 -- 26,688,812(+) TGTTG(A/T)AAATT utr-variant-3-prime
rs474045 -- 26,560,535(+) tacta(A/G)gtacc intron-variant
rs474485 -- 26,634,561(-) tggat(A/C)aatta intron-variant
rs474535 -- 26,588,630(-) CAAAA(C/G)GTTCG intron-variant
rs479278 -- 26,668,401(-) GAGGG(C/T)ACAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WASF3 Gene

Variant ID Type Subtype PubMed ID
dgv548e1 CNV Complex 17122850
nsv826597 CNV Gain 20364138
nsv969 CNV Insertion 18451855

Relevant External Links for WASF3 Gene

HapMap Linkage Disequilibrium report
WASF3
Human Gene Mutation Database (HGMD)
WASF3

Disorders for WASF3 Gene

(2) Novoseek inferred disease relationships for WASF3 Gene

Disease -log(P) Hits PubMed IDs
ganglioneuroblastoma 80.5 2
wiskott-aldrich syndrome 78.1 2

Relevant External Links for WASF3

Genetic Association Database (GAD)
WASF3
genes like me logo Genes that share disorders with WASF3: view

No data available for UniProtKB/Swiss-Prot for WASF3 Gene

Publications for WASF3 Gene

  1. Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. (PMID: 10381382) Suetsugu S. … Takenawa T. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. Genomic organization and expression profile of the human and mouse WAVE gene family. (PMID: 12856283) Sossey-Alaoui K. … Cowell J.K. (Mamm. Genome 2003) 3 4 23
  3. WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression. (PMID: 15907837) Sossey-Alaoui K. … Cowell J.K. (Exp. Cell Res. 2005) 3 23
  4. WAVE3 is associated with invasiveness in prostate cancer cells. (PMID: 19395286) Fernando H.S. … Jiang W.G. (Urol. Oncol. 2010) 3 23
  5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4

Products for WASF3 Gene

Sources for WASF3 Gene

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