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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WASF3 Gene

protein-coding   GIFtS: 64
GCID: GC13P027132

WAS Protein Family, Member 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WAS Protein Family, Member 31 2     WASP Family Protein Member 32 3
SCAR32 3 5     Brush-12
WAVE32 3 5     WASP Family Verprolin-Homologous Protein 32
Protein WAVE-32 3     Wiskott-Aldrich Syndrome Protein Family Member 32
Verprolin Homology Domain-Containing Protein 32 3     KIAA09003

External Ids:    HGNC: 127341   Entrez Gene: 108102   Ensembl: ENSG000001329707   OMIM: 6050685   UniProtKB: Q9UPY63   

Export aliases for WASF3 gene to outside databases

Previous GC identifers: GC13P025111 GC13P021111 GC13P026061 GC13P024929 GC13P026029 GC13P008010


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WASF3 Gene:
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that
forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal
verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve
changes in cell shape, motility or function. (provided by RefSeq, Jul 2008)

GeneCards Summary for WASF3 Gene: 
WASF3 (WAS protein family, member 3) is a protein-coding gene. Diseases associated with WASF3 include ganglioneuroblastoma, and wiskott-aldrich syndrome, and among its related super-pathways are Regulation of actin dynamics for phagocytic cup formation and Immune System. GO annotations related to this gene include actin binding. An important paralog of this gene is WASF2.

UniProtKB/Swiss-Prot: WASF3_HUMAN, Q9UPY6
Function: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and
small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal
organization. Required in the control of cell shape

Gene Wiki entry for WASF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for WASF3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWASF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for WASF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WASF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12   Ensembl cytogenetic band:  13q12.13   HGNC cytogenetic band: 13q12

WASF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WASF3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P027132:  view genomic region     (about GC identifiers)

Start:
27,131,840 bp from pter      End:
27,263,085 bp from pter
Size:
131,246 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WASF3_HUMAN, Q9UPY6 (See protein sequence)
Recommended Name: Wiskott-Aldrich syndrome protein family member 3  
Size: 502 amino acids; 55293 Da
Subunit: Binds actin and the Arp2/3 complex
Subcellular location: Cytoplasm, cytoskeleton
Sequence caution: Sequence=BAA74923.2; Type=Erroneous initiation;
Secondary accessions: O94974

Explore the universe of human proteins at neXtProt for WASF3: NX_Q9UPY6

Explore proteomics data for WASF3 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation by ABL1 promotes lamellipodia formation and cell migration
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UPY6

  • WASF3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WASF3 Protein Expression
    REFSEQ proteins: NP_006637.2  
    ENSEMBL proteins: 
     ENSP00000335055   ENSP00000354325  
    Reactome Protein details: Q9UPY6
    Human Recombinant Protein Products for WASF3: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for WASF3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0030027lamellipodium IEA--

    WASF3 for ontologies           About GeneDecksing



    WASF3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003124 WH2_dom

    Graphical View of Domain Structure for InterPro Entry Q9UPY6

    ProtoNet protein and cluster: Q9UPY6

    1 Blocks protein domain: IPB003124 Actin-binding WH2

    UniProtKB/Swiss-Prot: WASF3_HUMAN, Q9UPY6
    Domain: Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain
    Similarity: Belongs to the SCAR/WAVE family
    Similarity: Contains 1 WH2 domain


    WASF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WASF3_HUMAN, Q9UPY6
    Function: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and
    small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal
    organization. Required in the control of cell shape

         Genatlas biochemistry entry for WASF3:
    WAS protein family,member 3,widely expressed,strongly in brain,associating with the Arp2/3 complex a nucleating
    core for actin polymerization in vitro

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
         
    WASF3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for WASF3:
     Decreased focal adhesion (FA)   Increased cell death in breast 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Wasf3):
     hematopoietic system 

    WASF3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Wasf3tm1Tta for WASF3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for WASF3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WASF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WASF3 
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    miRNA
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    miRTarBase miRNAs that target WASF3:
    hsa-mir-200b (MIRT004296), hsa-mir-429 (MIRT004437), hsa-mir-200a (MIRT004524)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WASF3
    8/67 QIAGEN miScript miRNA Assays for microRNAs that regulate WASF3 (see all 67):
    hsa-miR-576-3p hsa-miR-3678-3p hsa-miR-642a hsa-miR-300 hsa-miR-106a hsa-miR-146a hsa-miR-93 hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASF3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WASF3 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.80
    Fcgamma receptor (FCGR) dependent phagocytosis0.80
    2Immune System
    Immune System0.56
    Innate Immune System0.50
    3Rho Family GTPases
    Rho Family GTPases0.61
    4Fc gamma R-mediated phagocytosis
    Fc gamma R-mediated phagocytosis
    5Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for WASF3
        Rho Family GTPases

    1 Cell Signaling Technology (CST) Pathway for WASF3
        Cytoskeletal Signaling

    4        Reactome Pathways for WASF3
        Regulation of actin dynamics for phagocytic cup formation
    Fcgamma receptor (FCGR) dependent phagocytosis
    Immune System
    Innate Immune System


    2         Kegg Pathways  (Kegg details for WASF3):
        Adherens junction
    Fc gamma R-mediated phagocytosis


    WASF3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WASF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/20 Interacting proteins for WASF3 (Q9UPY63 ENSP000003350554) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279863, ENSP000002743354I2D: score=3 STRING: ENSP00000274335
    ACTBP607093, ENSP000003499604I2D: score=2 STRING: ENSP00000349960
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    PIK3R2O004593, ENSP000002222544I2D: score=2 STRING: ENSP00000222254
    ACTR3P611583, ENSP000002632384I2D: score=3 STRING: ENSP00000263238
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS10381382
    GO:0007010cytoskeleton organization IMP--
    GO:0008360regulation of cell shape IMP--
    GO:0014003oligodendrocyte development IEA--
    GO:0030032lamellipodium assembly IEA--

    WASF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WASF3

    Search CenterWatch for drugs/clinical trials and news about WASF3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WASF3 gene: 
    NM_006646.5  

    Unigene Cluster for WASF3:

    WAS protein family, member 3
    Hs.618732  [show with all ESTs]
    Unigene Representative Sequence: NM_006646
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335327(uc001uqv.3) ENST00000496788 ENST00000361042(uc001uqw.3)

    miRNA
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    hsa-miR-576-3p hsa-miR-3678-3p hsa-miR-642a hsa-miR-300 hsa-miR-106a hsa-miR-146a hsa-miR-93 hsa-miR-298
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WASF3

    Additional mRNA sequence: 

    AB020707.2 AB026543.1 AF134305.1 AF454702.1 AK289845.1 AK294725.1 AL133590.1 BC050283.1 
    S69790.1 

    6 DOTS entries:

    DT.216021  DT.120780437  DT.120780442  DT.40224092  DT.91917303  DT.95077878 

    24/118 AceView cDNA sequences (see all 118):

    BM661863 AW771824 AI424535 AF134305 AI127514 Z44600 N34667 BM703028 
    BM462444 T08945 BU729251 BQ446736 F11179 NM_006646 AB020707 H39517 
    BU736040 BM671339 BM693418 BM668695 Z39727 AA629542 BU176547 AA701002 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WASF3 expression in normal human tissues (normalized intensities)      WASF3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACATATTA
    WASF3 Expression
    About this image


    WASF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Brain (Nervous System)
             Cerebellum

    See WASF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WASF3

    SOURCE GeneReport for Unigene cluster: Hs.618732

    UniProtKB/Swiss-Prot: WASF3_HUMAN, Q9UPY6
    Tissue specificity: Expressed in ovary and brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for WASF3 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wasf31 , 5 WAS protein family, member 31, 5 86.03(n)1
    93.81(a)1
      5 (85.23 cM)5
    2458801  NM_145155.31  NP_660137.11 
     1463849855 
    chicken
    (Gallus gallus)
    Aves WASF31 WAS protein family, member 3 79.31(n)
    87.03(a)
      418934  XM_417128.3  XP_417128.2 
    lizard
    (Anolis carolinensis)
    Reptilia WASF36
    Uncharacterized protein
    88(a)
    1 ↔ 1
    GL343306.1(803284-839200)
    zebrafish
    (Danio rerio)
    Actinopterygii BI883235.12   -- 79.38(n)    BI883235.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SCAR1 , 3 actin binding3
    CG4636-PA1
    47(a)3
    48.89(n)1
    45.67(a)1
      345191  NM_135633.21  NP_609477.11 
    worm
    (Caenorhabditis elegans)
    Secernentea B0280.136
    C31C9.66
    (see all 6)
    Protein C31C9.6
    (see all 6)
    8(a)
    7(a)
    (see all 6)
    possible ortholog
    possible ortholog
    (see all 6)
    III(7128899-7132048)
    II(13655884-13662081)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LAS176
    Actin assembly factor, activates the Arp2/3 protei...
    11(a)
    1 → many
    XV(675939-677840)


    ENSEMBL Gene Tree for WASF3 (if available)
    TreeFam Gene Tree for WASF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WASF3 gene
    WASF22  WASF12  
    2 SIMAP similar genes for WASF3 using alignment to 3 protein entries:     WASF3_HUMAN (see all proteins):
    WASF1    WASF2

    WASF3 for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for WASF3 (see all 8)
    PGOHUM00000248563 PGOHUM00000243140 PGOHUM00000245350 PGOHUM00000236831 PGOHUM00000242968


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2950 SNPs in WASF3 are shown (see all 2950)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs669307171,2
    C--8003859(+) TTTTC-/GTGTGT/
    GTGTGTGTGT
    GTGTG
    2 -- int1 cds11NA 2
    rs717794721,2
    C--8073005(+) CACAT-/ACACAC
            
    ACACA
    1 -- int10--------
    rs1484155871,2
    --27130126(+) TACCAC/TGAACC 1 -- us2k10--------
    rs1423559411,2
    --27130177(+) ACTGTA/TCTAGG 1 -- us2k10--------
    rs95122621,2
    C,F,H--27130190(+) TTATAA/GAAGGA 1 -- us2k1 tfbs3 trp330Minor allele frequency- G:0.10NA NS EA WA 3330
    rs1814141061,2
    --27130196(+) AAGGAA/GGAAAG 1 -- us2k10--------
    rs128717341,2
    C,F,H--27130292(+) CACTTT/CGGGAT 1 -- us2k121Minor allele frequency- C:0.18NA NS EA WA 2480
    rs1459571961,2
    C--27130384(+) CCAGGA/GAAATA 1 -- us2k10--------
    rs5420661,2
    C,F,O,A,H--27130462(+) CTAAAC/TATAGA 1 -- us2k124Minor allele frequency- N:0.00EA NA NS WA CSA 1423
    rs47695041,2
    C,F,A,H--27130516(+) AAGTCA/GTTTTA 1 -- us2k126Minor allele frequency- G:0.34NA NS EA WA CSA 2479

    HapMap Linkage Disequilibrium report for WASF3 (27131840 - 27263085 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WASF3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv969CNV Insertion18451855
    nsv826597CNV Gain20364138
    dgv548e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): WASF3
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605068    OMIM disorders: --

    7 diseases for WASF3:    About MalaCards
    ganglioneuroblastoma    wiskott-aldrich syndrome    gonorrhea    tuberculosis
    breast cancer    prostatitis    neuronitis


    WASF3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for WASF3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ganglioneuroblastoma 80.5 2 12185600 (1), 12856283 (1)
    wiskott-aldrich syndrome 78.1 3 16417486 (1), 19395286 (1)

    Genetic Association Database (GAD): WASF3

    Export disorders for WASF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WASF3 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with WASF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. (PubMed id 10381382)1, 2, 3, 9 Suetsugu S.... Takenawa T. (1999)
    2. Genomic organization and expression profile of the human and mouse WAVE gene family. (PubMed id 12856283)1, 2, 9 Sossey-Alaoui K.... Cowell J.K. (2003)
    3. c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration. (PubMed id 17623672)1, 2 Sossey-Alaoui K....Cowell J.K. (2007)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    6. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
    7. WAVE3 is associated with invasiveness in prostate can cer cells. (PubMed id 19395286)1, 9 Fernando H.S....Jiang W.G. (2010)
    8. WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression. (PubMed id 15907837)1, 9 Sossey-Alaoui K....Cowell J.K. (2005)
    9. WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma. (PubMed id 12185600)1, 9 Sossey-Alaoui K....Cowell J.K. (2002)
    10. Increased expression levels of WAVE3 are associated wi th the progression and metastasis of triple negative breast cancer. (PubMed id 22952619)1 Kulkarni S....Sossey-Alaoui K. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10810 HGNC: 12734 AceView: WASF3 Ensembl:ENSG00000132970 euGenes: HUgn10810
    ECgene: WASF3 Kegg: 10810 H-InvDB: WASF3

    (According to HUGE)
    About This Section
    HUGE: KIAA0900

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WASF3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WASF3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WASF3 gene:
    Search GeneIP for patents involving WASF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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