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Aliases & Descriptions for WASF3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| Brush-1 2 | | KIAA0900 1, 2, 3 | | OTTHUMP00000018160 2 | | SCAR3 1, 2, 3, 5 | | WAVE3 1, 2, 3, 5 |
| | | Descriptions |
|---|
| Protein WAVE-3 3 | | Verprolin homology domain-containing protein 3 3 | | WAS protein family, member 3 2 | | WASP family Verprolin-homologous protein 3 2 | | WASP family protein member 3 3 |
|
| | Search outside databases for aliases for WASF3 genePrevious GC identifers: GC13P025111 GC13P021111 GC13P026061 GC13P024929 |
Summaries for WASF3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for WASF3: This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. [provided by RefSeq] UniProtKB/Swiss-Prot: WASF3_HUMAN, Q9UPY6Function: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeletonGene Wiki entry for WASF3 |
Genomic Location for WASF3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the WASF3 gene 
Entrez Gene cytogenetic band: 13q12 Ensembl cytogenetic band: 13q12.13 HGNC cytogenetic band: 13q12WASF3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P026029:
(about GC identifiers)
Start:
|
26,029,840 bp from pter |
End:
|
26,161,082 bp from pter |
Size:
|
131,243 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000013.9 NT_024524.13
| Proteins for WASF3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: WASF3_HUMAN, Q9UPY6 (See
protein sequence)Recommended Name: Wiskott-Aldrich syndrome protein family member 3 Size: 502 amino acids; 55293 Da
Subunit: Binds actin and the Arp2/3 complex
Subcellular location: Cytoplasm, cytoskeleton
Secondary accessions: O94974Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006637.2
ENSEMBL proteins: ENSP00000370877 ENSP00000335055 ENSP00000354325
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for WASF3: Assays for WASF3: | Protein
Domains/ Families for WASF3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UPY6
ProtoNet protein and cluster: Q9UPY6 1 Blocks protein family: IPB003124 Actin-binding WH2
UniProtKB/Swiss-Prot: WASF3_HUMAN, Q9UPY6Domain: Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domainSimilarity: Belongs to the SCAR/WAVE familySimilarity: Contains 1 WH2 domain | Gene Function for WASF3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006646
Applied Biosystems Silencer® siRNAs for WASF3
Sigma-Aldrich siRNA for WASF3  Sigma-Aldrich shRNA for WASF3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006646                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006646                                  untagged cDNA clone in CMV expression vector: NM_006646 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006646
UniProtKB/Swiss-Prot: WASF3_HUMAN, Q9UPY6Function: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeletonGenatlas biochemistry entry for WASF3:WAS protein family,member 3,widely expressed,strongly in brain,associating with the Arp2/3 complex a nucleating core for actin polymerization in vitro1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003779 | actin binding |
IEA | -- | About this table | Pathways & Interactions for WASF3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for WASF3 
5/12 Interacting proteins for WASF3 (ENSP000003350553) via UniProtKB, MINT, and/or STRING (see all 12
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for WASF3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for WASF3
|
Transcripts for WASF3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006646
Sigma-Aldrich siRNA for WASF3  Sigma-Aldrich shRNA for WASF3  Explore Sigma-Aldrich super-pooled esiRNAs 
REFSEQ mRNAs for WASF3 gene: NM_006646.5               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006646                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006646                                  untagged cDNA clone in CMV expression vector: NM_006646  Additional cDNA sequence: AB020707.2 AB026543.1 AF134305.1 AF454702.1 AK289845.1 AK294725.1 AL133590.1 BC050283.1 S69790.1 6 DOTS entries: DT.216021 DT.120780437 DT.120780442 DT.40224092 DT.91917303 DT.95077878 24/118 AceView cDNA sequences (see all 118
):NM_006646 Z39727 BM671339 BM661863 BM462444 H39517 BQ446736 BM703028 BM693418 AI424535 AI127514 F11179 BU736040 Z44600 AA629542 T08945 BU729251 BM668695 BU176547 AF134305 AB020707 N34667 AW771824 BG773052
highest scoring ESTs for WASF3:S69790 AA063205 AA080918 AA084352 AA164760 AA393357 AA398689 AA625453 AA629542 AA701002 Unigene Cluster for WASF3: WAS protein family, member 3 Hs.635221 [show with all ESTs]Unigene Representative Sequence: NM_006646
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations: ENST00000381468
ENST00000335327
ENST00000361042
|
Expression for WASF3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| WASF3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for WASF3
1 / 2 / 3 3 probe-sets matching WASF3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ATACATATTA
SOURCE GeneReport for Unigene cluster: Hs.635221
Expression variation in blood from EXPOLDB for WASF3 UniProtKB/Swiss-Prot: WASF3_HUMAN, Q9UPY6Tissue specificity: Expressed in ovary and brain |
Orthologs for WASF3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for WASF3 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for WASF3
ENSEMBL Gene Tree for WASF3 | Paralogs for WASF3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for WASF3 gene
- WASF42 WASF22 WASF12
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for WASF3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for WASF3 (up to first 250kb)
|
Disorders & Mutations for WASF3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605068
2 Novoseek disease relationships for WASF3 gene
About this table
|
Medical News for WASF3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for WASF3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/22 PubMed articles for WASF3 gene (see all 22
):- Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. (PubMed id 10381382)1, 2, 3, 4 Suetsugu S.... Takenawa T. (1999)
- Genomic organization and expression profile of the human and mouse WAVE gene family. (PubMed id 12856283)1, 3, 4 Sossey-Alaoui K.... Cowell J.K. (2003)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)3, 4 Dunham A.... Ross M.T. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)3, 4 Nakajima D.... Nagase T. (2002)
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)3, 4 Nagase T....Ohara O. (1998)
- WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression. (PubMed id 15907837)1, 3 Sossey-Alaoui K....Cowell J.K. (2005)
- WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma. (PubMed id 12185600)1, 3 Sossey-Alaoui K....Cowell J.K. (2002)
- c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration. (PubMed id 17623672)3 Sossey-Alaoui K....Cowell J.K. (2007)
- Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage. (PubMed id 15670045)3 Kashiwagi H....Tomiyama Y. (2005)
- Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2. (PubMed id 15752430)3 Stovold C.F....Machesky L.M. (2005)
|
Search for WASF3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing WASF3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing WASF3
(According to HUGE)
About This Section
| |
Specialized Databases showing WASF3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for WASF3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for WASF3:

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| Antibodies & Assays for WASF3  (WAVE3) |
| | | | Search Tocris compounds for WASF3 |
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