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WASF3 Gene

protein-coding   GIFtS: 64
GCID: GC13P027132

WAS Protein Family, Member 3

  See WASF3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WAS Protein Family, Member 31 2     WASP Family Protein Member 32 3
SCAR32 3 5     Brush-12
WAVE32 3 5     WASP Family Verprolin-Homologous Protein 32
Protein WAVE-32 3     Wiskott-Aldrich Syndrome Protein Family Member 32
Verprolin Homology Domain-Containing Protein 32 3     KIAA09003

External Ids:    HGNC: 127341   Entrez Gene: 108102   Ensembl: ENSG000001329707   OMIM: 6050685   UniProtKB: Q9UPY63   

Export aliases for WASF3 gene to outside databases

Previous GC identifers: GC13P025111 GC13P021111 GC13P026061 GC13P024929 GC13P026029 GC13P008010


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WASF3 Gene:
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that
forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal
verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve
changes in cell shape, motility or function. (provided by RefSeq, Jul 2008)

GeneCards Summary for WASF3 Gene:
WASF3 (WAS protein family, member 3) is a protein-coding gene. Diseases associated with WASF3 include wiskott-aldrich syndrome, and ganglioneuroblastoma. GO annotations related to this gene include actin binding. An important paralog of this gene is WASF2.

UniProtKB/Swiss-Prot: WASF3_HUMAN, Q9UPY6
Function: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and
small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal
organization. Required in the control of cell shape

Gene Wiki entry for WASF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for WASF3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWASF3 promoter sequence
   Search Chromatin IP Primers for WASF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WASF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12   Ensembl cytogenetic band:  13q12.13   HGNC cytogenetic band: 13q12

WASF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WASF3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P027132:  view genomic region     (about GC identifiers)

Start:
27,131,840 bp from pter      End:
27,263,085 bp from pter
Size:
131,246 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WASF3_HUMAN, Q9UPY6 (See protein sequence)
Recommended Name: Wiskott-Aldrich syndrome protein family member 3  
Size: 502 amino acids; 55293 Da
Subunit: Binds actin and the Arp2/3 complex
Sequence caution: Sequence=BAA74923.2; Type=Erroneous initiation;
Secondary accessions: O94974

Explore the universe of human proteins at neXtProt for WASF3: NX_Q9UPY6

Explore proteomics data for WASF3 at MOPED

Post-translational modifications: 

  • Phosphorylation by ABL1 promotes lamellipodia formation and cell migration1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WASF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006637.2  
    ENSEMBL proteins: 
     ENSP00000335055   ENSP00000354325  
    Reactome Protein details: Q9UPY6

    WASF3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for WASF3

     
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    WASF3 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR028288 SCAR/WAVE_fam
     IPR003124 WH2_dom

    Graphical View of Domain Structure for InterPro Entry Q9UPY6

    ProtoNet protein and cluster: Q9UPY6

    1 Blocks protein domain: IPB003124 Actin-binding WH2

    UniProtKB/Swiss-Prot: WASF3_HUMAN, Q9UPY6
    Domain: Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain
    Similarity: Belongs to the SCAR/WAVE family
    Similarity: Contains 1 WH2 domain


    Find genes that share domains with WASF3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WASF3_HUMAN, Q9UPY6
    Function: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and
    small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal
    organization. Required in the control of cell shape

         Genatlas biochemistry entry for WASF3:
    WAS protein family,member 3,widely expressed,strongly in brain,associating with the Arp2/3 complex a nucleating
    core for actin polymerization in vitro

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
         
    Find genes that share ontologies with WASF3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for WASF3:
     Decreased focal adhesion (FA)   Increased cell death in breast 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Wasf3):
     hematopoietic system 

    Find genes that share phenotypes with WASF3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Wasf3tm1Tta for WASF3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WASF3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WASF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WASF3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WASF3

    miRNA
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    miRTarBase miRNAs that target WASF3:
    hsa-mir-200b-3p (MIRT004296), hsa-mir-429 (MIRT004437), hsa-mir-200a-3p (MIRT004524)

    Block miRNA regulation of human, mouse, rat WASF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WASF3 (see all 67):
    hsa-miR-576-3p hsa-miR-3678-3p hsa-miR-642a hsa-miR-300 hsa-miR-106a hsa-miR-146a hsa-miR-93 hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WASF3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASF3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WASF3_HUMAN, Q9UPY6: Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus3
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0030027lamellipodium IEA--

    Find genes that share ontologies with WASF3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WASF3 About    
    See pathways by source

    SuperPathContained pathways About
    1Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    2ERK Signaling
    Rho Family GTPases0.61
    3Fc gamma R-mediated phagocytosis
    Fc gamma R-mediated phagocytosis
    4Cytoskeletal Signaling
    Cytoskeletal Signaling
    5Adherens junction
    Adherens junction


    Find genes that share SuperPaths with WASF3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for WASF3
        Rho Family GTPases

    1 Cell Signaling Technology (CST) Pathway for WASF3
        Cytoskeletal Signaling

    1 Reactome Pathway for WASF3
        Regulation of actin dynamics for phagocytic cup formation


    2 Kegg Pathways  (Kegg details for WASF3):
        Adherens junction
    Fc gamma R-mediated phagocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WASF3
    Interactions:

        GeneGlobe Interaction Network for WASF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WASF3 (Q9UPY63 ENSP000003350554) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279863, ENSP000002743354I2D: score=3 STRING: ENSP00000274335
    ACTBP607093, ENSP000003499604I2D: score=2 STRING: ENSP00000349960
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    PIK3R2O004593, ENSP000002222544I2D: score=2 STRING: ENSP00000222254
    ACTR3P611583, ENSP000002632384I2D: score=3 STRING: ENSP00000263238
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS10381382
    GO:0007010cytoskeleton organization IMP--
    GO:0008360regulation of cell shape IMP--
    GO:0014003oligodendrocyte development IEA--
    GO:0030032lamellipodium assembly IEA--

    Find genes that share ontologies with WASF3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WASF3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WASF3 gene: 
    NM_006646.5  

    Unigene Cluster for WASF3:

    WAS protein family, member 3
    Hs.618732  [show with all ESTs]
    Unigene Representative Sequence: NM_006646
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335327(uc001uqv.3) ENST00000496788 ENST00000361042(uc001uqw.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat WASF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WASF3 (see all 67):
    hsa-miR-576-3p hsa-miR-3678-3p hsa-miR-642a hsa-miR-300 hsa-miR-106a hsa-miR-146a hsa-miR-93 hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Primer
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    OriGene qPCR primer pairs and template standards for WASF3
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      QuantiTect SYBR Green Assays in human, mouse, rat WASF3
      QuantiFast Probe-based Assays in human, mouse, rat WASF3

    Additional mRNA sequence: 

    AB020707.2 AB026543.1 AF134305.1 AF454702.1 AK289845.1 AK294725.1 AL133590.1 BC050283.1 
    S69790.1 

    6 DOTS entries:

    DT.216021  DT.120780437  DT.120780442  DT.40224092  DT.91917303  DT.95077878 

    Selected AceView cDNA sequences (see all 118):

    AA629542 AF134305 NM_006646 BM671339 BU736040 BM668695 AI424535 BM462444 
    F11179 Z44600 N34667 Z39727 BU729251 AI127514 BU176547 BM661863 
    T08945 BM693418 BQ446736 AB020707 AW771824 BM703028 H39517 AA976220 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WASF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACATATTA
    WASF3 Expression
    About this image


    WASF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Brain (Nervous System)
             Cerebellum
    WASF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WASF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.618732

    UniProtKB/Swiss-Prot: WASF3_HUMAN, Q9UPY6
    Tissue specificity: Expressed in ovary and brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WASF3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wasf31 , 5 WAS protein family, member 31, 5 85.36(n)1
    92.81(a)1
      5 (85.23 cM)5
    2458801  NM_145155.31  NP_660137.11 
     1463849855 
    chicken
    (Gallus gallus)
    Aves WASF36
    WAS protein family, member 3
    78(a)
    1 ↔ 1
    1(175770579-175792411)
    lizard
    (Anolis carolinensis)
    Reptilia WASF36
    WAS protein family, member 3
    88(a)
    1 ↔ 1
    GL343306.1(803284-839200)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wasf31 WAS protein family, member 3 72.19(n)
    77.78(a)
      779716  NM_001078795.1  NP_001072263.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI883235.12   -- 79.38(n)    BI883235.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SCAR3 actin binding 47(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea wve-16
    Protein WVE-1, isoform a
    33(a)
    1 → many
    I(11924785-11929507) WBGene00006958


    ENSEMBL Gene Tree for WASF3 (if available)
    TreeFam Gene Tree for WASF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WASF3 gene
    WASF22  WASF12  
    2 SIMAP similar genes for WASF3 using alignment to 3 protein entries:     WASF3_HUMAN (see all proteins):
    WASF1    WASF2

    Find genes that share paralogs with WASF3           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for WASF3 (see all 8)
    PGOHUM00000248563 PGOHUM00000243140 PGOHUM00000245350 PGOHUM00000236831 PGOHUM00000242968


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WASF3 (see all 2950)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs669307171,2
    C--8003859(+) TTTTC-/GTGTGT/
    GTGTGTGTGT
    GTGTG
    2 -- int1 cds11NA 2
    rs717794721,2
    C--8073005(+) CACAT-/ACACAC
            
    ACACA
    1 -- int10--------
    rs1484155871,2
    --27130126(+) TACCAC/TGAACC 1 -- us2k10--------
    rs1423559411,2
    --27130177(+) ACTGTA/TCTAGG 1 -- us2k10--------
    rs95122621,2
    C,F,H--27130190(+) TTATAA/GAAGGA 1 -- us2k1 tfbs3 trp330Minor allele frequency- G:0.10NA NS EA WA 3330
    rs1814141061,2
    --27130196(+) AAGGAA/GGAAAG 1 -- us2k10--------
    rs128717341,2
    C,F,H--27130292(+) CACTTT/CGGGAT 1 -- us2k121Minor allele frequency- C:0.18NA NS EA WA 2480
    rs1459571961,2
    C--27130384(+) CCAGGA/GAAATA 1 -- us2k10--------
    rs5420661,2
    C,F,O,A,H--27130462(+) CTAAAC/TATAGA 1 -- us2k124Minor allele frequency- N:0.00EA NA NS WA CSA 1423
    rs47695041,2
    C,F,A,H--27130516(+) AAGTCA/GTTTTA 1 -- us2k126Minor allele frequency- G:0.34NA NS EA WA CSA 2479

    HapMap Linkage Disequilibrium report for WASF3 (27131840 - 27263085 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WASF3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv969CNV Insertion18451855
    nsv826597CNV Gain20364138
    dgv548e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): WASF3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WASF3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605068    OMIM disorders: --

    2 diseases for WASF3:    
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    wiskott-aldrich syndrome    ganglioneuroblastoma


    Find genes that share disorders with WASF3           About GenesLikeMe

    2 Novoseek inferred disease relationships for WASF3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ganglioneuroblastoma 80.5 2 12185600 (1), 12856283 (1)
    wiskott-aldrich syndrome 78.1 3 16417486 (1), 19395286 (1)

    Genetic Association Database (GAD): WASF3

    Export disorders for WASF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WASF3 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with WASF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. (PubMed id 10381382)1, 2, 3, 9 Suetsugu S.... Takenawa T. (Biochem. Biophys. Res. Commun. 1999)
    2. Genomic organization and expression profile of the human and mouse WAVE gene family. (PubMed id 12856283)1, 2, 9 Sossey-Alaoui K.... Cowell J.K. (Mamm. Genome 2003)
    3. c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration. (PubMed id 17623672)1, 2 Sossey-Alaoui K.... Cowell J.K. (J. Biol. Chem. 2007)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    6. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    7. WAVE3 is associated with invasiveness in prostate cancer cells. (PubMed id 19395286)1, 9 Fernando H.S....Jiang W.G. (Urol. Oncol. 2010)
    8. WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression. (PubMed id 15907837)1, 9 Sossey-Alaoui K....Cowell J.K. (Exp. Cell Res. 2005)
    9. WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma. (PubMed id 12185600)1, 9 Sossey-Alaoui K....Cowell J.K. (Oncogene 2002)
    10. WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cells. (PubMed id 23318438)1 Teng Y....Cowell J.K. (Oncogene 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10810 HGNC: 12734 AceView: WASF3 Ensembl:ENSG00000132970 euGenes: HUgn10810
    ECgene: WASF3 Kegg: 10810 H-InvDB: WASF3

    (According to HUGE)
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    HUGE: KIAA0900

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WASF3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WASF3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WASF3 gene:
    Search GeneIP for patents involving WASF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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