Aliases for WASF3 Gene
External Ids for WASF3 Gene
Previous GeneCards Identifiers for WASF3 Gene
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014]
GeneCards Summary for WASF3 Gene
WASF3 (WAS Protein Family Member 3) is a Protein Coding gene. Diseases associated with WASF3 include Ganglioneuroblastoma and Wiskott-Aldrich Syndrome. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include actin binding. An important paralog of this gene is WASF1.
UniProtKB/Swiss-Prot for WASF3 Gene
Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.