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Aliases & Descriptions for WASF2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| IMD2 2 | | OTTHUMP00000003471 2 | | SCAR2 1, 2, 5 | | WAVE2 1, 2, 3, 5 | | dJ393P12.2 2 |
| | | Descriptions |
|---|
| Protein WAVE-2 3 | | Verprolin homology domain-containing protein 2 3 | | WAS protein family, member 2 2 | | WASP family Verprolin-homologous protein 2 2 | | WASP family protein member 2 3 | | suppressor of cyclic-AMP receptor (WASP-family) 2 |
|
| | Search outside databases for aliases for WASF2 genePrevious GC identifers: GC01P027836 GC01M026766 GC01M026965 GC01M027338 GC01M027336 GC01M027416 |
Summaries for WASF2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for WASF2: This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. [provided by RefSeq] UniProtKB/Swiss-Prot: WASF2_HUMAN, Q9Y6W5Function: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeletonGene Wiki entry for WASF2 |
Genomic Location for WASF2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the WASF2 gene 
Entrez Gene cytogenetic band: 1p36.11-p34.3 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36.11WASF2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M027603:
(about GC identifiers)
Start:
|
27,604,713 bp from pter |
End:
|
27,689,256 bp from pter |
Size:
|
84,544 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004610.18
| Proteins for WASF2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: WASF2_HUMAN, Q9Y6W5 (See
protein sequence)Recommended Name: Wiskott-Aldrich syndrome protein family member 2 Size: 498 amino acids; 54284 Da
Subunit: Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with C3orf10/HSPC300
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Cell projection, lamellipodium (By similarity). Note=At the interface between the lamellipodial actin meshwork and the membrane (By similarity)
PDB structures from and Proteopedia :2A40 (3D)
 
Secondary accessions: O60794 Q9UDY7Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_008921.1
ENSEMBL proteins: ENSP00000363131
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for WASF2: Assays for WASF2: | Protein
Domains/ Families for WASF2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9Y6W5
ProtoNet protein and cluster: Q9Y6W5 1 Blocks protein family: IPB003124 Actin-binding WH2
UniProtKB/Swiss-Prot: WASF2_HUMAN, Q9Y6W5Domain: Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domainSimilarity: Belongs to the SCAR/WAVE familySimilarity: Contains 1 WH2 domain | Gene Function for WASF2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006990
Applied Biosystems Silencer® siRNAs for WASF2
Sigma-Aldrich siRNA for WASF2  Sigma-Aldrich shRNA for WASF2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006990                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006990                                  untagged cDNA clones in CMV expression vector (see all 2): NM_006990 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006990
UniProtKB/Swiss-Prot: WASF2_HUMAN, Q9Y6W5Function: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeletonGenatlas biochemistry entry for WASF2:WAS protein family,member 2,widely expressed especially in peripheral blood leukocytes,associating with the Arp2/3 complex a nucleating core for actin polymerization in vitro9 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Wasf2):
1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for WASF2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for WASF2 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for WASF2 
5/43 Interacting proteins for WASF2 (ENSP000003631313 Q9Y6W52) via UniProtKB, MINT, and/or STRING (see all 43
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007188 | G-protein signaling, coupled to cAMP nucleotide second messenger |
TAS | 9732292 | | GO:0030036 | actin cytoskeleton organization |
TAS | 9732292 | About this table
|
Drugs & Compounds for WASF2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for WASF2 1 Novoseek chemical compound relationship for WASF2 gene
About this table
|
Transcripts for WASF2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006990
Sigma-Aldrich siRNA for WASF2  Sigma-Aldrich shRNA for WASF2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006990 REFSEQ mRNAs for WASF2 gene: NM_006990.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006990               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006990                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006990                                  untagged cDNA clones in CMV expression vector (see all 2): NM_006990  Additional cDNA sequence: AB026542.1 AK025566.1 AK075231.1 AK303011.1 AK304750.1 BC012329.1 BC032380.1 BC032724.1 BC040943.1 24 DOTS entries: DT.95373617 DT.449392 DT.75200157 DT.100865116 DT.121374876 DT.95373621 DT.100657452 DT.100868718 DT.40206553 DT.100657455 DT.100809336 DT.40124519 DT.102834411 DT.121374891 DT.121374900 DT.91893184 DT.92044140 DT.121316629 DT.121374820 DT.121374869 DT.70100286 DT.92453818 DT.95227674 DT.95373623 24/718 AceView cDNA sequences (see all 718
):AI089349 AW673029 AA291375 AI832877 BM449774 BU628363 F06958 BQ065362 BU740769 BE747068 BM561257 BM561708 AA641634 BM719102 AA643219 AI435386 AA160179 CA310103 BM817532 BM823284 AI076143 AY007122 BQ181254 CD245378
highest scoring ESTs for WASF2:BC012329 BC032724 BC040943 BG106821 BG339092 BQ890098 AA045129 AA069046 AA070549 AA076208 Unigene Cluster for WASF2: WAS protein family, member 2 Hs.590909 [show with all ESTs]Unigene Representative Sequence: NM_006990
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000374019
|
Expression for WASF2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| WASF2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for WASF2
1 / 2 / 3 8 probe-sets matching WASF2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTGAGACACC
SOURCE GeneReport for Unigene cluster: Hs.590909
Expression variation in blood from EXPOLDB for WASF2 UniProtKB/Swiss-Prot: WASF2_HUMAN, Q9Y6W5Tissue specificity: Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle |
Orthologs for WASF2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for WASF2 gene from 5 species
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
mouse (Mus musculus) |
Wasf25 |
4 (65.70 cM) |
WAS protein family, member 2 |
-- |
C76386 |
zebrafish (Danio rerio) |
zgc560102 |
-- |
similar to WAS protein family, member 2 |
76.65(n) |
394056 BC045859.1 |
fruit fly (Drosophila melanogaster) |
SCAR3 |
32C1--4 |
actin binding |
49(a) |
-- |
African clawed frog (Xenopus laevis) |
Xl.66692 |
-- |
Xenopus laevis, Similar to WAS protein family, member more |
76.67(n) |
BC049008.1 |
tropical clawed frog (Silurana tropicalis) |
Str.44742 |
-- |
Transcribed sequence with moderate similarity to protein more |
74.55(n) |
142014087 |
About this table Species with no ortholog for WASF2
ENSEMBL Gene Tree for WASF2 | Paralogs for WASF2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for WASF2 gene
- WASF41 2 WASF32 WASF12
|
SNPs/Variants for WASF2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for WASF2 (up to first 250kb)
|
Disorders & Mutations for WASF2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605875
1 Novoseek disease relationship for WASF2 gene
About this table
|
Medical News for WASF2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for WASF2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/56 PubMed articles for WASF2 gene (see all 56
):- Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. (PubMed id 10381382)1, 2, 3, 4 Suetsugu S.... Takenawa T. (1999)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Purification and architecture of the ubiquitous Wave complex. (PubMed id 15070726)3, 4 Gautreau A.... Kirschner M.W. (2004)
- IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. (PubMed id 11130076)3, 4 Miki H.... Takenawa T. (2000)
- Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation. (PubMed id 15657136)1, 3 Leng Y....Siminovitch K. (2005)
- Increased expression of Wiskott-Aldrich syndrome protein family verprolin-homologous protein 2 correlated with poor prognosis of hepatocellular carcinoma. (PubMed id 17020969)1, 3 Yang L.Y....Wu F. (2006)
- PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia. (PubMed id 15107862)1, 3 Oikawa T....Takenawa T. (2004)
- Abi1 is essential for the formation and activation of a WAVE2 signalling complex. (PubMed id 15048123)1, 3 Innocenti M....Scita G. (2004)
|
Search for WASF2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing WASF2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing WASF2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WASF2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for WASF2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for WASF2:

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