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WASF2 Gene

protein-coding   GIFtS: 61
GCID: GC01M027730

WAS Protein Family, Member 2

  See WASF2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WAS Protein Family, Member 21 2     WASF42
WAVE22 3 5     dJ393P12.22
Protein WAVE-22 3     Putative Wiskott-Aldrich Syndrome Protein Family Member 42
Verprolin Homology Domain-Containing Protein 22 3     Suppressor Of Cyclic-AMP Receptor (WASP-Family)2
WASP Family Protein Member 22 3     WASP Family Protein Member 42
SCAR22 5     WASP Family Verprolin-Homologous Protein 22
IMD22     Wiskott-Aldrich Syndrome Protein Family Member 22

External Ids:    HGNC: 127331   Entrez Gene: 101632   Ensembl: ENSG000001581957   OMIM: 6058755   UniProtKB: Q9Y6W53   

Export aliases for WASF2 gene to outside databases

Previous GC identifers: GC01P027836 GC01M026766 GC01M026965 GC01M027338 GC01M027336 GC01M027416 GC01M027603


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WASF2 Gene:
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that
forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal
verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve
changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on
recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a
pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for WASF2 Gene:
WASF2 (WAS protein family, member 2) is a protein-coding gene. Diseases associated with WASF2 include wiskott-aldrich syndrome. GO annotations related to this gene include actin binding. An important paralog of this gene is WASF3.

UniProtKB/Swiss-Prot: WASF2_HUMAN, Q9Y6W5
Function: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and
small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that
regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction
with the Arp2/3 complex

Gene Wiki entry for WASF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the WASF2 gene promoter:
         TBP   RFX1   GATA-3   Pax-5   Arnt   MEF-2A   Ik-2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWASF2 promoter sequence
   Search Chromatin IP Primers for WASF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WASF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

WASF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WASF2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M027730:  view genomic region     (about GC identifiers)

Start:
27,730,730 bp from pter      End:
27,816,678 bp from pter
Size:
85,949 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WASF2_HUMAN, Q9Y6W5 (See protein sequence)
Recommended Name: Wiskott-Aldrich syndrome protein family member 2  
Size: 498 amino acids; 54284 Da
Subunit: Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of
ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1
1 PDB 3D structure from and Proteopedia for WASF2:
2A40 (3D)    
Secondary accessions: B4DZN0 O60794 Q9UDY7
Alternative splicing: 2 isoforms:  Q9Y6W5-1   Q9Y6W5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WASF2: NX_Q9Y6W5

Explore proteomics data for WASF2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WASF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001188333.1  NP_008921.1  

    ENSEMBL proteins: 
     ENSP00000396211   ENSP00000439883  
    Reactome Protein details: Q9Y6W5

    WASF2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for WASF2

     
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    WASF2 Antibody Products:

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    Abcam antibodies for WASF2
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    LSBio Antibodies in human, mouse, rat for WASF2

    WASF2 Assay Products:

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    Cloud-Clone Corp. ELISAs for WASF2
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    Search eBioscience for ELISAs for WASF2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR028288 SCAR/WAVE_fam
     IPR003124 WH2_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y6W5

    ProtoNet protein and cluster: Q9Y6W5

    1 Blocks protein domain: IPB003124 Actin-binding WH2

    UniProtKB/Swiss-Prot: WASF2_HUMAN, Q9Y6W5
    Domain: Binds and activates the Arp2/3 complex via the C-terminal domain. Interacts with actin via the WH2 domain
    Similarity: Belongs to the SCAR/WAVE family
    Similarity: Contains 1 WH2 domain


    Find genes that share domains with WASF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WASF2_HUMAN, Q9Y6W5
    Function: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and
    small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that
    regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction
    with the Arp2/3 complex

         Genatlas biochemistry entry for WASF2:
    WAS protein family,member 2,widely expressed especially in peripheral blood leukocytes,associating with the Arp2/3
    complex a nucleating core for actin polymerization in vitro

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI11130076
    GO:0032403protein complex binding IMP--
         
    Find genes that share ontologies with WASF2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for WASF2:
     Increased cell death HMECs cel  Increased cell death in breast  Increased number of cells in m 

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Wasf2):
     cardiovascular system  embryogenesis  growth/size/body  homeostasis/metabolism  liver/biliary system 
     mortality/aging  muscle  nervous system 

    Find genes that share phenotypes with WASF2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Wasf2tm1Tta for WASF2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WASF2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WASF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WASF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WASF2

    miRNA
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    miRTarBase miRNAs that target WASF2:
    hsa-mir-877-3p (MIRT037001), hsa-mir-7-5p (MIRT025754), hsa-mir-940 (MIRT036610), hsa-mir-146a-5p (MIRT007243), hsa-mir-1 (MIRT023756), hsa-mir-34a-5p (MIRT025275), hsa-mir-26b-5p (MIRT029364), hsa-mir-124-3p (MIRT022583), hsa-mir-425-5p (MIRT039325), hsa-mir-1224-5p (MIRT036553)

    Block miRNA regulation of human, mouse, rat WASF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WASF2 (see all 134):
    hsa-miR-361-5p hsa-miR-1321 hsa-miR-146a hsa-miR-1224-3p hsa-miR-4305 hsa-miR-3921 hsa-miR-4275 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidWASF2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WASF2

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WASF2

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WASF2_HUMAN, Q9Y6W5: Cytoplasm, cytoskeleton (By similarity). Cell projection, lamellipodium (By similarity).
    Note=At the interface between the lamellipodial actin meshwork and the membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    nucleus3
    endosome2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005622intracellular IDA17101133
    GO:0005769early endosome IEA--
    GO:0005829cytosol TAS--
    GO:0015629actin cytoskeleton TAS10970852

    Find genes that share ontologies with WASF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WASF2 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    3Salmonella infection (KEGG)
    Shigellosis0.30
    Salmonella infection0.30
    4G protein signaling RAC1 in cellular process
    G protein signaling RAC1 in cellular process0.37
    5CDC42 signaling events
    RAC1 signaling pathway0.34


    Find genes that share SuperPaths with WASF2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for WASF2
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for WASF2
        G-protein signaling RAC1 in cellular process

    4 BioSystems Pathways for WASF2
        Regulation of Actin Cytoskeleton
    E-cadherin signaling in the nascent adherens junction
    ErbB1 downstream signaling
    RAC1 signaling pathway

    1 Reactome Pathway for WASF2
        Regulation of actin dynamics for phagocytic cup formation


    Selected Kegg Pathways  (Kegg details for WASF2) (see all 6):
        Adherens junction
    Fc gamma R-mediated phagocytosis
    Regulation of actin cytoskeleton
    Bacterial invasion of epithelial cells
    Shigellosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WASF2: 
              Adherens Junctions in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WASF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WASF2 (Q9Y6W51, 2, 3 ENSP000003962114) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABI1Q8IZP02, 3, ENSP000003653124MINT-45987 MINT-45991 MINT-3390382 MINT-45984 I2D: score=3 STRING: ENSP00000365312
    GAS7O608612, 3, ENSP000003226084MINT-72918 I2D: score=3 STRING: ENSP00000322608
    ABI3Q9P2A42, 3, ENSP000002259414MINT-3390340 I2D: score=2 STRING: ENSP00000225941
    SORBS3O605042, ENSP000002401234MINT-7147173 MINT-7146815 MINT-7146792 STRING: ENSP00000240123
    CYFIP2Q96F072, 3, ENSP000003909484MINT-45985 I2D: score=2 STRING: ENSP00000390948
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    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001667ameboidal cell migration IEA--
    GO:0006897endocytosis ----
    GO:0006928cellular component movement ----
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS9732292

    Find genes that share ontologies with WASF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WASF2

    1 Novoseek inferred chemical compound relationship for WASF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 13.7 8 15657136 (3), 18701695 (1), 14752106 (1)



    Find genes that share compounds with WASF2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WASF2 gene (2 alternative transcripts): 
    NM_001201404.1  NM_006990.3  

    Unigene Cluster for WASF2:

    WAS protein family, member 2
    Hs.469244  [show with all ESTs]
    Unigene Representative Sequence: NM_006990
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430629(uc001bof.2 uc010ofl.2) ENST00000536657
    miRNA
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    hsa-miR-361-5p hsa-miR-1321 hsa-miR-146a hsa-miR-1224-3p hsa-miR-4305 hsa-miR-3921 hsa-miR-4275 hsa-miR-3916
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      QuantiFast Probe-based Assays in human, mouse, rat WASF2

    Additional mRNA sequence: 

    AB026542.1 AJ431612.1 AK024540.1 AK025566.1 AK075231.1 AK303011.1 AK304750.1 AY007122.1 
    BC001524.2 BC001855.2 BC012329.1 BC032380.1 BC032724.1 BC040943.1 

    Selected DOTS entries (see all 32):

    DT.95373617  DT.449392  DT.100853905  DT.75200157  DT.100865116  DT.100058193  DT.100657452  DT.121374876 
    DT.95373621  DT.100868718  DT.121374889  DT.40206553  DT.100657455  DT.100809336  DT.40124519  DT.92044140 
    DT.100657451  DT.102834411  DT.121281060  DT.121374820  DT.121374891  DT.121374900  DT.91893184  DT.95227674 

    Selected AceView cDNA sequences (see all 718):

    AA039272 BQ447165 BU737509 BM719102 AW069072 BQ049283 CA310103 BM456949 
    AI085014 AA846721 BU846319 BQ059102 BU859150 CB158815 AY007122 AI799639 
    BU190142 BQ181254 BM449774 BQ231675 BM458797 F12425 BQ710846 AI300155 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WASF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATACTTAAA
    WASF2 Expression
    About this image

    WASF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WASF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.469244

    UniProtKB/Swiss-Prot: WASF2_HUMAN, Q9Y6W5
    Tissue specificity: Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood
    leukocytes, but not in skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WASF2: 
              Adherens Junctions in human mouse rat
              Cell Motility in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat WASF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WASF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WASF2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wasf21 , 5 WAS protein family, member 21, 5 84.38(n)1
    87.07(a)1
      4 (66.22 cM)5
    2426871  NM_153423.61  NP_700472.11 
     1331305055 
    chicken
    (Gallus gallus)
    Aves WASF21 WAS protein family, member 2 78.27(n)
    85.51(a)
      426359  XM_424015.4  XP_424015.3 
    lizard
    (Anolis carolinensis)
    Reptilia WASF26
    WAS protein family, member 2
    82(a)
    1 ↔ 1
    GL343464.1(378447-393469)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.66692 Xenopus laevis, Similar to WAS protein family, member more 76.67(n)    BC049008.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc560102 similar to WAS protein family, member 2 76.65(n)   394056  BC045859.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SCAR3 actin binding 49(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea wve-16
    Protein WVE-1, isoform a
    32(a)
    1 → many
    I(11924785-11929507) WBGene00006958


    ENSEMBL Gene Tree for WASF2 (if available)
    TreeFam Gene Tree for WASF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WASF2 gene
    WASF32  WASF12  
    2 SIMAP similar genes for WASF2 using alignment to 2 protein entries:     WASF2_HUMAN (see all proteins):
    WASF1    WASF3

    Find genes that share paralogs with WASF2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for WASF2
    PGOHUM00000241739


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WASF2 (see all 1547)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs579168991,2
    C--26008423(+) AAAAA-/A/AAAA
            
    TTAGC
    2 -- int11NA 2
    rs25047631,2
    C,F,A,H--27730258(+) CAGCCG/CCCTCG 2 -- ds500112Minor allele frequency- C:0.36NS EA NA WA CSA 782
    rs2020495801,2
    C--27730276(+) TCAGG-/AGGGGAGA 2 -- ds50010--------
    rs1852308281,2
    --27730288(+) GGGGCA/GTGCAG 2 -- ds50010--------
    rs1905047531,2
    --27730376(+) GATGCC/TGGCCA 2 -- ds50010--------
    rs1819968521,2
    --27730433(+) TGATGC/GAAACA 2 -- ds50010--------
    rs773195491,2
    C--27730477(+) CACCCC/ACTTTC 2 -- ds50012Minor allele frequency- A:0.04NA 122
    rs570909821,2
    C,F--27730584(+) ACACAA/GTGCAC 2 -- ds50013Minor allele frequency- G:0.40WA CSA 122
    rs1466390111,2
    --27730703(+) TCCCAC/TTAAAA 2 -- ds50010--------
    rs1863320171,2
    --27730707(+) ATTAAA/CACAAT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for WASF2 (27730730 - 27816678 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for WASF2 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2459986CNV Deletion19546169
    esv2661510CNV Deletion23128226
    esv2745730CNV Deletion23290073
    esv2049917CNV Deletion18987734
    esv4796CNV Deletion18987735
    esv2248480CNV Deletion18987734
    esv2671164CNV Deletion23128226
    nsv159932CNV Loss16902084
    dgv203n71CNV Loss21882294
    dgv205n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WASF2
    DNA2.0 Custom Variant and Variant Library Synthesis for WASF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605875    OMIM disorders: --

    1 disease for WASF2:    
    About MalaCards
    wiskott-aldrich syndrome

    1 disease from the University of Copenhagen DISEASES database for WASF2:
    Wiskott-Aldrich syndrome

    Find genes that share disorders with WASF2           About GenesLikeMe

    1 Novoseek inferred disease relationship for WASF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 90.6 7 18701695 (1), 15657136 (1), 16417406 (1), 16417486 (1) (see all 7)

    Genetic Association Database (GAD): WASF2

    Export disorders for WASF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WASF2 gene, integrated from 10 sources (see all 88):
    (articles sorted by number of sources associating them with WASF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. (PubMed id 10381382)1, 2, 3, 9 Suetsugu S.... Takenawa T. (Biochem. Biophys. Res. Commun. 1999)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. Purification and architecture of the ubiquitous Wave complex. (PubMed id 15070726)1, 2 Gautreau A.... Kirschner M.W. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. (PubMed id 11130076)1, 2 Miki H.... Takenawa T. (Nature 2000)
    6. Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation. (PubMed id 15657136)1, 9 Leng Y....Siminovitch K. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    7. Increased expression of Wiskott-Aldrich syndrome protein family verprolin-homologous protein 2 correlated with poor prognosis of hepatocellular carcinoma. (PubMed id 17020969)1, 9 Yang L.Y....Wu F. (Clin. Cancer Res. 2006)
    8. PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia. (PubMed id 15107862)1, 9 Oikawa T....Takenawa T. (Nat. Cell Biol. 2004)
    9. Abi1 is essential for the formation and activation of a WAVE2 signalling complex. (PubMed id 15048123)1, 9 Innocenti M....Scita G. (Nat. Cell Biol. 2004)
    10. WAVE/Scars in platelets. (PubMed id 15280206)1, 9 Oda A....Takenawa T. (Blood 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10163 HGNC: 12733 AceView: WASF2 Ensembl:ENSG00000158195 euGenes: HUgn10163
    ECgene: WASF2 Kegg: 10163 H-InvDB: WASF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WASF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WASF2 gene:
    Search GeneIP for patents involving WASF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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