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Aliases for WASF2 Gene

Aliases for WASF2 Gene

  • WAS Protein Family Member 2 2 3 5
  • Verprolin Homology Domain-Containing Protein 2 3 4
  • WAS Protein Family, Member 2 2 3
  • WASP Family Protein Member 2 3 4
  • Protein WAVE-2 3 4
  • WAVE2 3 4
  • Putative Wiskott-Aldrich Syndrome Protein Family Member 4 3
  • Suppressor Of Cyclic-AMP Receptor (WASP-Family) 3
  • WASP Family Verprolin-Homologous Protein 2 3
  • WASP Family Protein Member 4 3
  • DJ393P12.2 3
  • SCAR2 3
  • WASF4 3
  • IMD2 3

External Ids for WASF2 Gene

Previous GeneCards Identifiers for WASF2 Gene

  • GC01P027836
  • GC01M026766
  • GC01M026965
  • GC01M027338
  • GC01M027336
  • GC01M027416
  • GC01M027603
  • GC01M027730

Summaries for WASF2 Gene

Entrez Gene Summary for WASF2 Gene

  • This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for WASF2 Gene

WASF2 (WAS Protein Family Member 2) is a Protein Coding gene. Diseases associated with WASF2 include wiskott-aldrich syndrome and narcissistic personality disorder. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include actin binding and protein complex binding. An important paralog of this gene is WASF1.

UniProtKB/Swiss-Prot for WASF2 Gene

  • Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.

Gene Wiki entry for WASF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WASF2 Gene

Genomics for WASF2 Gene

Regulatory Elements for WASF2 Gene

Promoters for WASF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WASF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for WASF2 Gene

Chromosome:
1
Start:
27,404,226 bp from pter
End:
27,490,187 bp from pter
Size:
85,962 bases
Orientation:
Minus strand

Genomic View for WASF2 Gene

Genes around WASF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WASF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WASF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WASF2 Gene

Proteins for WASF2 Gene

  • Protein details for WASF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6W5-WASF2_HUMAN
    Recommended name:
    Wiskott-Aldrich syndrome protein family member 2
    Protein Accession:
    Q9Y6W5
    Secondary Accessions:
    • B4DZN0
    • O60794
    • Q9UDY7

    Protein attributes for WASF2 Gene

    Size:
    498 amino acids
    Molecular mass:
    54284 Da
    Quaternary structure:
    • Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1. Interacts with human cytomegalovirus protein UL135.

    Three dimensional structures from OCA and Proteopedia for WASF2 Gene

    Alternative splice isoforms for WASF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WASF2 Gene

Proteomics data for WASF2 Gene at MOPED

Post-translational modifications for WASF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WASF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for WASF2 (WAVE2)

No data available for DME Specific Peptides for WASF2 Gene

Domains & Families for WASF2 Gene

Gene Families for WASF2 Gene

Protein Domains for WASF2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y6W5

UniProtKB/Swiss-Prot:

WASF2_HUMAN :
  • Binds and activates the Arp2/3 complex via the C-terminal domain. Interacts with actin via the WH2 domain.
  • Belongs to the SCAR/WAVE family.
Domain:
  • Binds and activates the Arp2/3 complex via the C-terminal domain. Interacts with actin via the WH2 domain.
  • Contains 1 WH2 domain.
Family:
  • Belongs to the SCAR/WAVE family.
genes like me logo Genes that share domains with WASF2: view

Function for WASF2 Gene

Molecular function for WASF2 Gene

GENATLAS Biochemistry:
WAS protein family,member 2,widely expressed especially in peripheral blood leukocytes,associating with the Arp2/3 complex a nucleating core for actin polymerization in vitro
UniProtKB/Swiss-Prot Function:
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.

Gene Ontology (GO) - Molecular Function for WASF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with WASF2: view
genes like me logo Genes that share phenotypes with WASF2: view

Animal Models for WASF2 Gene

MGI Knock Outs for WASF2:

Animal Model Products

  • Taconic Biosciences Mouse Models for WASF2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WASF2 Gene

Localization for WASF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WASF2 Gene

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Note=At the interface between the lamellipodial actin meshwork and the membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WASF2 Gene COMPARTMENTS Subcellular localization image for WASF2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 3
plasma membrane 3
endosome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for WASF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 17101133
GO:0005769 early endosome IEA --
GO:0005829 cytosol TAS --
GO:0005911 cell-cell junction IEA --
GO:0031209 SCAR complex IMP 21107423
genes like me logo Genes that share ontologies with WASF2: view

Pathways & Interactions for WASF2 Gene

genes like me logo Genes that share pathways with WASF2: view

SIGNOR curated interactions for WASF2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for WASF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006897 endocytosis IEA --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS 9732292
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0010592 positive regulation of lamellipodium assembly IMP 18560548
genes like me logo Genes that share ontologies with WASF2: view

Drugs & Compounds for WASF2 Gene

(1) Drugs for WASF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with WASF2: view

Transcripts for WASF2 Gene

mRNA/cDNA for WASF2 Gene

Unigene Clusters for WASF2 Gene

WAS protein family, member 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WASF2 Gene

No ASD Table

Relevant External Links for WASF2 Gene

GeneLoc Exon Structure for
WASF2
ECgene alternative splicing isoforms for
WASF2

Expression for WASF2 Gene

mRNA expression in normal human tissues for WASF2 Gene

Protein differential expression in normal tissues from HIPED for WASF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.7) and Cervix (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for WASF2 Gene



SOURCE GeneReport for Unigene cluster for WASF2 Gene Hs.469244

mRNA Expression by UniProt/SwissProt for WASF2 Gene

Q9Y6W5-WASF2_HUMAN
Tissue specificity: Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.
genes like me logo Genes that share expression patterns with WASF2: view

Protein tissue co-expression partners for WASF2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WASF2 Gene

Orthologs for WASF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for WASF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WASF2 35
  • 93.29 (n)
  • 95.05 (a)
WASF2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WASF2 35
  • 88.25 (n)
  • 88.52 (a)
WASF2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wasf2 35
  • 84.38 (n)
  • 87.07 (a)
Wasf2 16
Wasf2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WASF2 35
  • 99.4 (n)
  • 99.28 (a)
WASF2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WASF2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WASF2 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves WASF2 35
  • 78.27 (n)
  • 85.51 (a)
WASF2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WASF2 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4474 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6669 35
zebrafish
(Danio rerio)
Actinopterygii wasf2 35
  • 70.54 (n)
  • 80.81 (a)
zgc56010 35
wasf2 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta SCAR 37
  • 49 (a)
SCAR 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea wve-1 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2335 36
  • 41 (a)
OneToMany
Species with no ortholog for WASF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WASF2 Gene

ENSEMBL:
Gene Tree for WASF2 (if available)
TreeFam:
Gene Tree for WASF2 (if available)

Paralogs for WASF2 Gene

Paralogs for WASF2 Gene

(2) SIMAP similar genes for WASF2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for WASF2 Gene

genes like me logo Genes that share paralogs with WASF2: view

Variants for WASF2 Gene

Sequence variations from dbSNP and Humsavar for WASF2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs9634 -- 27,404,463(-) TTAGG(A/C/G/T)GTCTG utr-variant-3-prime
rs12856 -- 27,404,270(+) ATGTT(A/G)GCATT utr-variant-3-prime
rs13582 -- 27,405,660(-) GAGGC(C/G)CTCTG utr-variant-3-prime
rs715224 -- 27,446,896(+) GAGCA(A/C/T)TCTTC intron-variant
rs733899 -- 27,410,841(+) TGTGC(C/T)ACCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WASF2 Gene

Variant ID Type Subtype PubMed ID
nsv526051 CNV Gain 19592680
dgv203n71 CNV Loss 21882294
nsv516766 CNV Loss 19592680
esv2661510 CNV Deletion 23128226
dgv14n27 CNV Loss 19166990
dgv205n71 CNV Loss 21882294
esv2459986 CNV Deletion 19546169
esv2248480 CNV Deletion 18987734
esv2745730 CNV Deletion 23290073
esv4796 CNV Deletion 18987735
esv2671164 CNV Deletion 23128226
esv2049917 CNV Deletion 18987734
nsv159932 CNV Loss 16902084

Variation tolerance for WASF2 Gene

Residual Variation Intolerance Score: 34.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WASF2 Gene

HapMap Linkage Disequilibrium report
WASF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WASF2 Gene

Disorders for WASF2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for WASF2 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search WASF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WASF2

Genetic Association Database (GAD)
WASF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WASF2
genes like me logo Genes that share disorders with WASF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WASF2 Gene

Publications for WASF2 Gene

  1. Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. (PMID: 10381382) Suetsugu S. … Takenawa T. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23 67
  2. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. (PMID: 16417406) Weiner O.D. … Kirschner M.W. (PLoS Biol. 2006) 3 23
  3. Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin. (PMID: 16483316) Mitsushima M. … Kioka N. (Genes Cells 2006) 3 23
  4. Increased expression of Wiskott-Aldrich syndrome protein family verprolin-homologous protein 2 correlated with poor prognosis of hepatocellular carcinoma. (PMID: 17020969) Yang L.Y. … Wu F. (Clin. Cancer Res. 2006) 3 23
  5. WAVE/Scars in platelets. (PMID: 15280206) Oda A. … Takenawa T. (Blood 2005) 3 23

Products for WASF2 Gene

Sources for WASF2 Gene

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