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WASF1 Gene

protein-coding GIFtS: 69

GC06M110527

WAS protein family, member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ31482 ^²
KIAA0269 ^¹, ², ³
OTTHUMP00000016990 ^²
SCAR1 ^¹, ², ³, ⁵
WAVE ^¹, ², ⁵
WAVE1 ^¹, ², ³, ⁵

Descriptions
Protein WAVE-1 ^³
Verprolin homology domain-containing protein 1 ^², ³
WAS protein family, member 1 ^²
WASP family protein member 1 ^³
Wiskott-Aldrich syndrome protein family member 1 ^²
homology of dictyostelium scar 1 ^²

External Ids
HGNC: 12732¹
Entrez Gene: 8936²
UniProtKB: Q92558³
Ensembl: ENSG00000112290⁷

Search outside databases for aliases for WASF1 gene

Previous GC identifers: GC06M110256 GC06M110443 GC06M110466

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for WASF1:

The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family,

plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin

cytoskeleton required for membrane ruffling. It has been shown to associate with an actin

nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich

syndrome is a disease of the immune system, likely due to defects in regulation of actin

cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have

been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: WASF1_HUMAN, Q92558

Function: Downstream effector molecules involved in the transmission of signals from tyrosine

kinase receptors and small GTPases to the actin cytoskeleton

Gene Wiki entry for WASF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the WASF1 gene

Entrez Gene cytogenetic band: 6q21-q22 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21-q22

WASF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M110527: (about GC identifiers)

Start:	110,527,715 bp from pter
End:	110,607,900 bp from pter
Size:	80,186 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_025741.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WASF1_HUMAN, Q92558 (See protein sequence)

Recommended Name: Wiskott-Aldrich syndrome protein family member 1

Size: 559 amino acids; 61652 Da

Subunit: Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and

WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing

activated WASF1. The complex can also be activated by NCK1 (By similarity). Binds actin and the

Arp2/3 complex. Interacts with BAIAP2

Subcellular location: Cytoplasm, cytoskeleton. Note=Dot-like pattern in the cytoplasm. Concentrated

in Rac-regulated membrane-ruffling areas

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001020105.1 NP_001020106.1 NP_001020107.1 NP_003922.1

ENSEMBL proteins:

ENSP00000376368 ENSP00000376367 ENSP00000352425 ENSP00000376366 ENSP00000376365 ENSP00000265601

ENSP00000357934

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (WAVE 1)
	Human Recombinant Proteins from Abnova (WASF1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005739	mitochondrion	IDA	18029348
GO:0015629	actin cytoskeleton	TAS	9843499

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Antibodies for WASF1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of WASF1
	Sigma-Aldrich Antibody Arrays and Antibodies for WASF1
	R&D Systems Antibodies for WASF1 (WASF1/WAVE1)
	Antibodies from Abcam (WAVE 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (WASF1)
	Novus Biologicals Antibodies for WASF1

Assays for WASF1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q92558

ProtoNet protein and cluster: Q92558

1 Blocks protein family: IPB003124 Actin-binding WH2

UniProtKB/Swiss-Prot: WASF1_HUMAN, Q92558

Domain: Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology

(VPH) domain

Similarity: Belongs to the SCAR/WAVE family

Similarity: Contains 1 WH2 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WASF1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001024934

Applied Biosystems Silencer® siRNAs for WASF1

Sigma-Aldrich siRNA for WASF1

Sigma-Aldrich shRNA for WASF1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001024934
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001024934
untagged cDNA clones in CMV expression vector (see all 4): NM_001024934

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003931

UniProtKB/Swiss-Prot: WASF1_HUMAN, Q92558

Function: Downstream effector molecules involved in the transmission of signals from tyrosine

kinase receptors and small GTPases to the actin cytoskeleton

Genatlas biochemistry entry for WASF1:

WAS protein family,member1,widely expressed,strongly in brain,associating with the Arp2/3 complex a

nucleating core for actin polymerization in vitro,potentially involved in the regulation of RAC

induced of actin cytoskeleton required for membrane ruffling

8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Wasf1):

behavior/neurological	digestive/alimentary	growth/size	lethality-postnatal	life span-post-weaning/aging
liver/biliary system	muscle	nervous system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for WASF1 (Your Favorite Gene powered by Ingenuity)

Actin Cytoskeleton Signaling
Regulation of Actin-based Motility by Rho

GeneDecks WASF1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for WASF1

5/42 Interacting proteins for WASF1 (Q92558² ENSP00000352425³) via UniProtKB, MINT, and/or STRING (see all 42 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCKAP1	Q9Y2A7², ENSP00000354251³	MINT-15828 STRING (score=.998)
ABL1	P00519²	MINT-16419 MINT-16418 MINT-16420
BAIAP2	ENSP00000316338³	STRING (score=.998)
ENSG00000134075	ENSP00000256463³	STRING (score=.998)
CYFIP2	ENSP00000366799³	STRING (score=.997)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006461	protein complex assembly	NAS	10381382
GO:0006928	cell motion	TAS	2775266
GO:0030041	actin filament polymerization	TAS	9843499

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WASF1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WASF1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001024934

Sigma-Aldrich siRNA for WASF1

Sigma-Aldrich shRNA for WASF1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001024934 NM_001024935 NM_001024936 NM_003931

REFSEQ mRNAs for WASF1 gene (4 alternative transcripts):

NM_001024934.1 NM_001024935.1 NM_001024936.1 NM_003931.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001024934 NM_001024935 NM_001024936 NM_003931

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001024934
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001024934
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001024934

Additional cDNA sequence:

AF134303.1 AK097838.1 BC044591.1 BC068546.1 CR601979.1 CR622893.1 D87459.1

21 DOTS entries:

DT.97786672 DT.95178572 DT.65284123 DT.100736715 DT.95359203 DT.451630 DT.40116047 DT.100730920

DT.100792169 DT.121322679 DT.100047436 DT.121322706 DT.121322771 DT.121322718 DT.97781907 DT.100658902

DT.121322689 DT.121322726 DT.121322836 DT.75173015 DT.97787869

24/122 AceView cDNA sequences (see all 122 ):

CB215686 BI461486 F10585 NM_003931 AW612159 CR622893 BX477915 AU142666

BC044591 BM458302 CD171651 AF134303 AI928895 CR601979 D87459 BX425187

AK097838 AI306688 AW590436 AI929146 BQ422314 AA846712 T87835 BU171316

highest scoring ESTs for WASF1:

BC044591 BI458943 BI462105 BX425187 D87459 AA081721 AA349198 AA379446 AA846712 AA885055

Unigene Cluster for WASF1:

WAS protein family, member 1

Hs.75850 [show with all ESTs]

Unigene Representative Sequence: NM_003931

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for WASF1

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	^	11	^	12	^	13a	·	13b
SP1:					-																-		-				-
SP2:					-		-																				-
SP3:							-																				-
SP4:

About this scheme

ECgene alternative splicing isoforms for WASF1

7 Ensembl transcripts including schematic representations:

ENST00000392589 ENST00000392588 ENST00000359451 ENST00000392587 ENST00000392586 ENST00000265601

ENST00000368938

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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WASF1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for WASF1

¹ / ² / ³

3 probe-sets matching WASF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37190_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D87459	0.80	1.00	0.91	1
204165_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003931	0.60	1.00	0.82	1
204165_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks WASF1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAACTTACAT

SOURCE GeneReport for Unigene cluster: Hs.75850
Expression variation in blood from EXPOLDB for WASF1
UniProtKB/Swiss-Prot: WASF1_HUMAN, Q92558
Tissue specificity: Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney,
pancreas, thymus, small intestine and peripheral blood

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WASF1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WASF1¹	--	WAS protein family, member 1	96.48(n) 99.46(a)	475024 XM_863373.1 XP_868466.1
chimpanzee (Pan troglodytes)	WASF1¹	--	WAS protein family, member 1	99.55(n) 100(a)	462935 XM_518686.2 XP_518686.2
cow (Bos taurus)	WASF1¹	--	WAS protein family, member 1	96.06(n) 99.46(a)	531488 NM_001034017.2 NP_001029189.2
rat (Rattus norvegicus)	Wasf1¹	--	WAS protein family, member 1	88.85(n) 97.5(a)	294568 NM_001025114.1 NP_001020285.1
mouse (Mus musculus)	Wasf1^{1, 5}	10 (25.00 cM)⁵	WASP family 1^{1, 5}	91(n)¹ 98.39(a)¹	83767¹ NM_031877.2¹ NP_114083.1¹ AA272058⁵ AF290877⁵ (see all 13)

About this table Species with no ortholog for WASF1

ENSEMBL Gene Tree for WASF1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for WASF1 gene

WASF4² WASF2² WASF3²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/279 NCBI SNPs in WASF1 are shown (see all 279 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 74)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6568632^1,2	A,C,F,H	110528054(+)	`GTAGAT/CACAGC`	4	--	ut3¹		8	EA NA EU WA	630
	rs1462492^1,2	A,C,F,H,O	110577151(+)	`TGCCCG/ACTTTA`	4	--	int¹		7	EU EA WA NA	560
	rs6940347^1,2	A,C,F,H	110532739(+)	`ACAGAT/CGCCAG`	4	--	int¹		8	EU EA WA	816
	rs4945850^1,2	A,C,F,H	110554336(+)	`CAAATG/TTAACT`	4	--	int¹		4	EU EA WA	420
--	rs12665858^1,2	A,C,F,H	110552699(+)	`ggcttT/Gggtgg`	4	--	int¹		2	EA	156
	rs11751590^1,2	A,C,F,H	110592636(+)	`aaaatG/Ctcaac`	4	--	int¹		8	EU EA WA	838
	rs3828927^1,2	A,C,F,H	110531034(+)	`ACAAAT/CAATGT`	4	--	int¹		6	EU EA WA	598
	rs4945851^1,2	A,C,F,H	110603926(+)	`TATACT/CGTTTC`	4	--	int¹		9	NA EU EA WA	730
--	rs719850^1,2	A,C,F,H	110553001(-)	`ATAAAA/AA /C/TCTCTGA`	4	--	int¹		4	EU EA WA	412
	rs4299857^1,2	A,C,F,H	110541866(+)	`aagatA/Gtatta`	4	--	int¹		7	EU EA WA NA	558

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HapMap Linkage Disequilibrium images for WASF1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 605035

4 Novoseek disease relationships for WASF1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
scar1	95.29	34	9889097 (8), 12601690 (6), 11747816 (6), 12429845 (4) (see all 5)
wiskott-aldrich syndrome	92.50	16	12601690 (1), 12853106 (1), 18287015 (1), 9889097 (1) (see all 16)
scar	57.60	5	11282031 (1), 17314411 (1), 14765121 (1), 12482910 (1) (see all 5)
mental retardation	19.11	2	12578964 (1), 17215396 (1)

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1 PharmGKB disease relationship for WASF1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/69 PubMed articles for WASF1 gene (see all 69 ):

Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. (PubMed id 9889097)^{1, 2, 3, 4} Machesky L.M. and Insall R.H. (1998)
WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac. (PubMed id 9843499)^{1, 2, 3} Miki H....Takenawa T. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. (PubMed id 11130076)^{3, 4} Miki H.... Takenawa T. (2000)
SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development. (PubMed id 9732292)^{3, 4} Bear J.E.... Saxe C.L. III (1998)
Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)^{3, 4} Nagase T....Nomura N. (1996)
[Expression of WAVE1 in childhood acute lymphocytic leukemia and in the apoptosis of Jurkat cells induced by adriamycin.] (PubMed id 18947485)^{1, 3} Wang Z....Xu W.Q. (2008)
Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. (PubMed id 10381382)^{1, 3} Suetsugu S.... Takenawa T. (1999)
WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines. (PubMed id 18287015)^{1, 3} Sung J.Y....Kim Y. (2008)
Vascular endothelial growth factor causes translocation of p47phox to membrane ruffles through WAVE1. (PubMed id 12855698)^{1, 3} Wu R.F....Terada L.S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 8936	HGNC: 12732	AceView: WASF1	Ensembl:ENSG00000112290	euGenes: HUgn8936
ECgene: WASF1	H-InvDB: WASF1

(According to HUGE)
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HUGE: KIAA0269

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for WASF1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for WASF1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for WASF1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for WASF1		Antibodies for WASF1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for WASF1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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WASF1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for WASF1

Summaries
for WASF1

Genomic Location
for WASF1

Proteins
for WASF1

Protein Domains/
Families
for WASF1

Gene Function
for WASF1

Pathways & Interactions
for WASF1

Drugs & Compounds
for WASF1

Transcripts
for WASF1

Expression
for WASF1

Orthologs
for WASF1

Paralogs
for WASF1

SNPs/Variants
for WASF1

Disorders & Mutations
for WASF1

Medical News
for WASF1

Publications
for WASF1

Search for WASF1

Genome Databases showing WASF1

Other Databases showing WASF1

Specialized Databases showing WASF1

Licensable Technologies
for WASF1

Services
for WASF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WASF1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor WASF1

Summariesfor WASF1

Genomic Locationfor WASF1

Proteinsfor WASF1

Protein Domains/Familiesfor WASF1

Gene Functionfor WASF1

Pathways & Interactionsfor WASF1

Drugs & Compoundsfor WASF1

Transcriptsfor WASF1

Expression for WASF1

Orthologsfor WASF1

Paralogsfor WASF1

SNPs/Variantsfor WASF1

Disorders & Mutationsfor WASF1

Medical Newsfor WASF1

Publicationsfor WASF1

Search for WASF1

Genome Databases showing WASF1

Other Databases showing WASF1

Specialized Databases showing WASF1

Licensable Technologiesfor WASF1

Servicesfor WASF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for WASF1

Summaries
for WASF1

Genomic Location
for WASF1

Proteins
for WASF1

Protein Domains/
Families
for WASF1

Gene Function
for WASF1

Pathways & Interactions
for WASF1

Drugs & Compounds
for WASF1

Transcripts
for WASF1

Expression
for WASF1

Orthologs
for WASF1

Paralogs
for WASF1

SNPs/Variants
for WASF1

Disorders & Mutations
for WASF1

Medical News
for WASF1

Publications
for WASF1

Licensable Technologies
for WASF1

Services
for WASF1