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Aliases & Descriptions for WARS2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases (Mt)TrpRS 3 EC 6.1.1.2 3 OTTHUMP00000014272 2 OTTHUMP00000014273 2 TrpRS 1 , 2 , 3
Descriptions Tryptophan--tRNA ligase 3 mitochondrial tryptophanyl tRNA synthetase 2 2 tryptophan tRNA ligase 2, mitochondrial 2 tryptophan-tRNA ligase 2 tryptophanyl tRNA synthetase 2, mitochondrial 2
Search outside databases for aliases for WARS2 genePrevious GC identifers: GC01M120022 GC01M118413 GC01M118720 GC01M118920
Summaries for WARS2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for WARS2 : Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Becauseof their central role in linking amino acids with nucleotide triplets contained in tRNAs,aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution.Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and amitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase.Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq] Gene Wiki entry for WARS2
Genomic Location for WARS2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the WARS2 gene Entrez Gene cytogenetic band: 1p13.3-p13.1 Ensembl cytogenetic band: 1p12 HGNC cytogenetic band: 1p12 WARS2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M119286:
(about GC identifiers )
Start:
119,375,362 bp from pter
End:
119,484,818 bp from pter
Size:
109,457 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.9 NT_019273.18 Proteins for WARS2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: SYWM_HUMAN, Q9UGM6 (See
protein sequence )Recommended Name: Tryptophanyl-tRNA synthetase, mitochondrial precursor Size : 360 amino acids; 40147 Da
Subcellular location : Mitochondrion matrix
Secondary accessions : Q53FT4 Q5VUD2 Q86TQ0
REFSEQ proteins (2 alternative transcripts):
NP_056651.1 NP_957715.1 ENSEMBL proteins: ENSP00000235521 ENSP00000358434 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for WARS2: Assays for WARS2:
Protein
Domains/ Families for WARS2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9UGM6 ProtoNet protein and cluster: Q9UGM6
1 Blocks protein family : IPB002305 Aminoacyl-tRNA synthetase UniProtKB/Swiss-Prot: SYWM_HUMAN, Q9UGM6 Similarity : Belongs to the class-I aminoacyl-tRNA synthetase family
Gene Function for WARS2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
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Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
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siRNAs from
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_201263 Applied Biosystems Silencer ® siRNAs for WARS2 Sigma-Aldrich siRNA and siRNA Panels for WARS2 Sigma-Aldrich shRNA for WARS2 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_015836                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_015836                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_015836  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015836 UniProtKB/Swiss-Prot: SYWM_HUMAN, Q9UGM6 Catalytic activity : ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)Enzyme Number (IUBMB): EC 6.1.1.2
Genatlas biochemistry entry for WARS2 :tryptophanyl-tRNA synthetase 2,mitochondrial 4 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for WARS2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for WARS2 (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for WARS2 5/11 Interacting proteins for WARS2 (ENSP00000235521 3 ) via UniProtKB, MINT, and/or STRING (see all 11
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006436 tryptophanyl-tRNA aminoacylation
IEA --
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Drugs & Compounds for WARS2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for WARS2 4 Novoseek chemical compound relationships for WARS2 gene
About this table
Transcripts for WARS2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_201263 Sigma-Aldrich siRNA and siRNA Panels for WARS2 Sigma-Aldrich shRNA for WARS2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_015836 NM_201263
REFSEQ mRNAs for WARS2 gene (2 alternative transcripts): NM_015836.3 NM_201263.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015836 NM_201263
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_015836                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_015836                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_015836  
Additional cDNA sequence: AJ242739.1 AK056365.1 AK223197.1 AK296088.1 AK296799.1 AK299547.1 AK300295.1 AK313740.1 BC021722.1 BC037821.2 BC039889.1 BC044575.1 CR590727.1 CR599172.1 CR621696.1
10 DOTS entries : DT.97840154 DT.95270607 DT.313244 DT.444801 DT.91854676 DT.91744934 DT.97840153 DT.100813783 DT.121449946 DT.101956725
24/137 AceView cDNA sequences (see all 137
):BM985401 BE275735 BQ014588 NM_015836 BQ432000 BM834499 BC039889 BX355578 BU839073 AA194238 Z40749 BM802067 AW195495 BU181461 AL519147 CR590727 BP336381 CR621696 CR599172 BE394734 AW068958 NM_201263 BX355579 BF447233
highest scoring ESTs for WARS2 :AA227572 AA251468 AA332220 AJ242739 AL709389 BC021722 BC039889 BC044575 BE274756 BE275735
Unigene Cluster for WARS2: Tryptophanyl tRNA synthetase 2, mitochondrial Hs.523506 [show with all ESTs ] Unigene Representative Sequence: BC039889 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for WARS2 ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b SP1 :       -                 SP2 :       -     -     -         SP3 :                      
About this scheme ECgene alternative splicing isoforms for WARS2 2 Ensembl transcripts including schematic representations : ENST00000235521
ENST00000369426
Expression for WARS2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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WARS2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for WARS2 1 / 2 / 3
8 probe-sets matching WARS2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GGTAAAGGAASOURCE GeneReport for Unigene cluster: Hs.523506
Orthologs for WARS2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for WARS2 gene from 5/19 species (see all 19
)
About this table Species with no ortholog for WARS2 ENSEMBL Gene Tree for WARS2 Paralogs for WARS2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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--
SNPs/Variants for WARS2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for WARS2 (up to first 250kb)
Disorders & Mutations for WARS2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 604733
Medical News for WARS2 (Possibly Related Articles in
Doctor's Guide )
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Publications for WARS2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/24 PubMed articles for WARS2 gene (see all 24
): Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase. (PubMed id 10828066) 1, 2, 3, 4 Jorgensen R....Justesen J. (2000) Assignment of the human mitochondrial tryptophanyl-tRNA synthetase (WARS2) to 1p13.3-->p13.1 by radiation hybrid mapping. (PubMed id 10072595) 1, 2, 3 Martinez-Dominguez M.T....Hansen L.L. (1998) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311. (PubMed id 17726052) 3 Guo L.T....Jin Y.X. (2007) Transcriptome analysis of human gastric cancer. (PubMed id 16341674) 3 Oh J.H....Kim N.S. (2005) A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase. (PubMed id 14757836) 3 Liu J....Schimmel P. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149) 3 Suzuki Y.... Sugano S. (1997) Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298) 3 Maruyama K. and Sugano S. (1994)
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Genome Databases showing WARS2
(According to
Entrez Gene ,
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing WARS2
(According to HUGE )
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Specialized Databases showing WARS2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for WARS2 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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