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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WARS2 Gene

protein-coding   GIFtS: 62
GCID: GC01M119573

Tryptophanyl TRNA Synthetase 2, Mitochondrial

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tryptophanyl TRNA Synthetase 2, Mitochondrial1 2     Tryptophan TRNA Ligase 2, Mitochondrial2
(Mt)TrpRS2 3     Tryptophan--TRNA Ligase, Mitochondrial2
TrpRS2 3     Tryptophan-TRNA Ligase2
EC 6.1.1.23 8     Tryptophanyl-TRNA Synthetase, Mitochondrial2
mitochondrial1     Tryptophanyl-TRNA Synthetase3
Tryptophan TRNA Ligase 21     EC 6.1.18

External Ids:    HGNC: 127301   Entrez Gene: 103522   Ensembl: ENSG000001168747   OMIM: 6047335   UniProtKB: Q9UGM63   

Export aliases for WARS2 gene to outside databases

Previous GC identifers: GC01M120022 GC01M118413 GC01M118720 GC01M118920 GC01M119286 GC01M117432


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WARS2 Gene:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their
central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are
thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase
exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial
tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described.
(provided by RefSeq, Jul 2008)

GeneCards Summary for WARS2 Gene: 
WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial) is a protein-coding gene. Diseases associated with WARS2 include pneumonia, and cervicitis, and among its related super-pathways are Cytosolic tRNA aminoacylation and Generic Transcription Pathway. GO annotations related to this gene include tryptophan-tRNA ligase activity and ATP binding.

Gene Wiki entry for WARS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WARS2 gene promoter:
         AML1a   MEF-2   POU3F2   LCR-F1   MEF-2A   POU2F1   POU2F1b   POU2F1a   POU2F1c   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWARS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for WARS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WARS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p12   Ensembl cytogenetic band:  1p12   HGNC cytogenetic band: 1p12

WARS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WARS2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M119573:  view genomic region     (about GC identifiers)

Start:
119,573,839 bp from pter      End:
119,683,295 bp from pter
Size:
109,457 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYWM_HUMAN, Q9UGM6 (See protein sequence)
Recommended Name: Tryptophan--tRNA ligase, mitochondrial precursor  
Size: 360 amino acids; 40147 Da
Subcellular location: Mitochondrion matrix
Secondary accessions: B1ALR1 B2R9D4 Q53FT4 Q5VUD2 Q86TQ0
Alternative splicing: 2 isoforms:  Q9UGM6-1   Q9UGM6-2   

Explore the universe of human proteins at neXtProt for WARS2: NX_Q9UGM6

Explore proteomics data for WARS2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UGM6

  • 4/5 DME Specific Peptides for WARS2 (Q9UGM6) (see all 5)
     LGNYLGA  KMSKSDP  AADILLY  VPVGEDQ 

    WARS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WARS2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_056651.1  NP_957715.1  

    ENSEMBL proteins: 
     ENSP00000358434   ENSP00000235521   ENSP00000438807  
    Reactome Protein details: Q9UGM6
    Human Recombinant Protein Products for WARS2: 
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    Novus Biologicals WARS2 Proteins
    Novus Biologicals WARS2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WARS2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix TAS--

    WARS2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for WARS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    aaRS1: Aminoacyl tRNA synthetases / Class I

    5 InterPro protein domains:
     IPR001412 aa-tRNA-synth_I_CS
     IPR024109 Trp-tRNA-ligase_bac-type
     IPR014729 Rossmann-like_a/b/a_fold
     IPR002306 Trp-tRNA-ligase
     IPR002305 aa-tRNA-synth_Ic

    Graphical View of Domain Structure for InterPro Entry Q9UGM6

    ProtoNet protein and cluster: Q9UGM6

    1 Blocks protein domain: IPB002305 Aminoacyl-tRNA synthetase

    UniProtKB/Swiss-Prot: SYWM_HUMAN, Q9UGM6
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family


    WARS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYWM_HUMAN, Q9UGM6
    Catalytic activity: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)

         Genatlas biochemistry entry for WARS2:
    tryptophanyl-tRNA synthetase 2,mitochondrial

         Enzyme Numbers (IUBMB): EC 6.1.1.21 2 EC 6.1.12

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004830tryptophan-tRNA ligase activity IEA--
    GO:0005524ATP binding IEA--
         
    WARS2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Wars2 (no phenotypes)

    WARS2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WARS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WARS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WARS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WARS2 

    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate WARS2 (see all 21):
    hsa-miR-320a hsa-let-7d hsa-let-7c hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-508-5p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidWARS2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WARS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WARS2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Mitochondrial tRNA aminoacylation0.50
    Aminoacyl-tRNA biosynthesis0.54
    2Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for WARS2
        tRNA Aminoacylation
    Gene Expression
    Mitochondrial tRNA aminoacylation


    1         Kegg Pathway  (Kegg details for WARS2):
        Aminoacyl-tRNA biosynthesis


    WARS2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WARS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/23 Interacting proteins for WARS2 (Q9UGM63 ENSP000002355214) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPD1P108093, ENSP000003400194I2D: score=2 STRING: ENSP00000340019
    CADP277083, ENSP000002647054I2D: score=1 STRING: ENSP00000264705
    ABCD2Q9UBJ23I2D: score=1 
    ANAPC2Q9UJX63I2D: score=1 
    HDAC1Q135473I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis IEA--
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006436tryptophanyl-tRNA aminoacylation IEA--
    GO:0010467gene expression TAS--

    WARS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    WARS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WARS2 (SYWM)

    5 HMDB Compounds for WARS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Tryptophan(-)-tryptophan (see all 53)73-22-3--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for WARS2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Tryptophan(-)-Tryptophan (see all 14)73-22-3targetinhibitor16724112 16636268 16639024 17428498 17114825
    enzymesubstrate inhibitor16724112 16636268 16639024 17428498 17114825 16724112 16636268 16639024 17428498 17114825

    4 Novoseek inferred chemical compound relationships for WARS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trna(trp) 89.3 3 11600701 (2), 7743129 (1)
    aminoacyl-trna 75.4 3 7743129 (1), 8643392 (1), 12438642 (1)
    trna 55.9 4 7743129 (1), 8643392 (1), 17637340 (1)
    atp 15.8 2 7743129 (1), 19477411 (1)

    Search CenterWatch for drugs/clinical trials and news about WARS2 / SYWM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WARS2 gene (2 alternative transcripts): 
    NM_015836.3  NM_201263.2  

    Unigene Cluster for WARS2:

    Tryptophanyl tRNA synthetase 2, mitochondrial
    Hs.523506  [show with all ESTs]
    Unigene Representative Sequence: BC039889
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369426(uc010oxf.2 uc001ehm.3) ENST00000235521(uc001ehn.3 uc010oxg.2 uc010oxh.2)
    ENST00000495746 ENST00000497402 ENST00000497761 ENST00000537870(uc010oxi.2)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate WARS2 (see all 21):
    hsa-miR-320a hsa-let-7d hsa-let-7c hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-508-5p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidWARS2 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WARS2

    Additional mRNA sequence: 

    AJ242739.1 AK056365.1 AK223197.1 AK296088.1 AK296799.1 AK299547.1 AK300295.1 AK313740.1 
    BC021722.1 BC037821.2 BC039889.1 BC044575.1 

    10 DOTS entries:

    DT.97840154  DT.95270607  DT.313244  DT.444801  DT.91854676  DT.91744934  DT.97840153  DT.100813783 
    DT.121449946  DT.101956725 

    24/137 AceView cDNA sequences (see all 137):

    NM_015836 BF447233 BX355579 BM802067 BU629288 BC039889 AA251354 BF438361 
    NM_201263 BU181461 AW068958 BU839073 BP336381 BQ014588 BX355578 AW195495 
    CR621696 BQ432000 CR590727 BM834499 Z40749 AL519147 CR599172 AA194238 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for WARS2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                    -                                             
    SP2:                    -           -           -                     
    SP3:                                                                  


    ECgene alternative splicing isoforms for WARS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WARS2 expression in normal human tissues (normalized intensities)      WARS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTAAAGGAA
    WARS2 Expression
    About this image


    WARS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
             brain/midbrain   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             renal vesicle e12.5   
     
     Uterus (Reproductive System)
             endometrial endothelial cell   

    See WARS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WARS2

    SOURCE GeneReport for Unigene cluster: Hs.523506
        SABiosciences Custom PCR Arrays for WARS2
    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WARS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WARS2 gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wars21 , 5 tryptophanyl tRNA synthetase 2 (mitochondrial)1, 5 85.37(n)1
    86.39(a)1
      3 (43.03 cM)5
    705601  NM_027462.41  NP_081738.21 
     991410685 
    chicken
    (Gallus gallus)
    Aves WARS21 tryptophanyl tRNA synthetase 2, mitochondrial 65.2(n)
    63.6(a)
      418312  XM_416536.3  XP_416536.3 
    lizard
    (Anolis carolinensis)
    Reptilia WARS26
    tryptophanyl tRNA synthetase 2, mitochondrial
    69(a)
    1 ↔ 1
    GL343218.1(550391-577260)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.65832 Xenopus laevis transcribed sequence with weak similarity more 75.63(n)    BJ067886.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb77g082 wufb77g08 76.49(n)   322959  AL914927.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74411 , 3 tryptophan-tRNA ligase3
    CG74411
    52(a)3
    55.21(n)1
    52.94(a)1
      399891  NM_140761.21  NP_649018.21 
    worm
    (Caenorhabditis elegans)
    Secernentea wrs-23
    prx-101
    Protein PRX-101 42(a)3
    48.75(n)1
    44.06(a)1
      III(5308215-5311711)3
    1757191  NM_001026029.21  NP_001021200.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSW1(YDR268W)4
    MSW11
    Mitochondrial tryptophanyl-tRNA synthetase4
    Msw1p1
    48.93(n)1
    43.73(a)1
      4(1004004-1005143)4
    8518611, 4  NP_010554.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons OVA41 tryptophanyl-tRNA synthetase 49.11(n)
    40.18(a)
      817126  NM_179739.3  NP_850070.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g07434001 hypothetical protein 48.02(n)
    41.45(a)
      4326551  NM_001050753.1  NP_001044218.1 


    ENSEMBL Gene Tree for WARS2 (if available)
    TreeFam Gene Tree for WARS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WARS2 gene

    WARS2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for WARS2
    PGOHUM00000258497


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1951 SNPs in WARS2 are shown (see all 1951)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1832113571,2
    --119573859(+) TACCTG/TTAGTT 2 -- ut310--------
    rs120861,2
    C,F,H--119573860(+) ACCTTT/CAGTTT 2 -- ut31 ese321Minor allele frequency- C:0.12NA NS EA WA 2474
    rs1879008451,2
    --119573963(+) ACTTAC/GAGACA 2 -- ut310--------
    rs89281,2
    C,F,A,H--119574074(-) ACGCCG/CCATCC 2 -- ut31 ese321Minor allele frequency- C:0.27MN NA NS EA WA CSA 1342
    rs1473085081,2
    --119574103(+) TTCTGA/GCACAA 2 -- ut310--------
    rs1907039701,2
    --119574106(+) TGACAC/TAAGGA 2 -- ut310--------
    rs1829492381,2
    --119574116(+) ACTACA/TCTACT 2 -- ut310--------
    rs1878454761,2
    C--119574157(+) CTCAAA/CAACCT 2 -- ut310--------
    rs1929324811,2
    --119574202(+) ACTGAC/TAAAAA 2 -- ut310--------
    rs26452931,2
    C,F,H--119574282(+) TTTTCA/TTTTTC 2 -- ut316Minor allele frequency- T:0.04NS EA WA 526

    HapMap Linkage Disequilibrium report for WARS2 (119573839 - 119683295 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for WARS2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2475310CNV Deletion19546169
    nsv521813CNV Loss19592680
    dgv16n21CNV Loss19592680
    nsv524681CNV Gain19592680
    nsv831192CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604733    OMIM disorders: --

    4 diseases for WARS2:    About MalaCards
    pneumonia    cervicitis    tuberculosis    gastric cancer


    WARS2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WARS2
    Human Genome Epidemiology (HuGE) Navigator: WARS2 (2 documents)

    Export disorders for WARS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WARS2 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with WARS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase. (PubMed id 10828066)1, 2, 3, 9 Jorgensen R....Justesen J. (2000)
    2. Assignment of the human mitochondrial tryptophanyl-tRNA synthetase (WARS2) to 1p13.3-->p13.1 by radiation hybrid mapping. (PubMed id 10072595)1, 3, 9 Martinez-Dominguez M.T....Hansen L.L. (1998)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distr ibution. (PubMed id 20935629)1 Heid I.M....Lindgren C.M. (2010)
    9. Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311. (PubMed id 17726052)1 Guo L.T....Jin Y.X. (2007)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10352 HGNC: 12730 AceView: WARS2 Ensembl:ENSG00000116874 euGenes: HUgn10352
    ECgene: WARS2 Kegg: 10352 H-InvDB: WARS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WARS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WARS2 gene:
    Search GeneIP for patents involving WARS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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