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WARS2 Gene

protein-coding   GIFtS: 62
GCID: GC01M119573

Tryptophanyl TRNA Synthetase 2, Mitochondrial

  Search for WARS2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tryptophanyl TRNA Synthetase 2, Mitochondrial1 2     Tryptophan TRNA Ligase 2, Mitochondrial2
(Mt)TrpRS2 3     Tryptophan--TRNA Ligase, Mitochondrial2
TrpRS2 3     Tryptophan-TRNA Ligase2
EC 6.1.1.23 8     Tryptophanyl-TRNA Synthetase, Mitochondrial2
mitochondrial1     Tryptophanyl-TRNA Synthetase3
Tryptophan TRNA Ligase 21     EC 6.1.18

External Ids:    HGNC: 127301   Entrez Gene: 103522   Ensembl: ENSG000001168747   OMIM: 6047335   UniProtKB: Q9UGM63   

Export aliases for WARS2 gene to outside databases

Previous GC identifers: GC01M120022 GC01M118413 GC01M118720 GC01M118920 GC01M119286 GC01M117432


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WARS2 Gene:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their
central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are
thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase
exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial
tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described.
(provided by RefSeq, Jul 2008)

GeneCards Summary for WARS2 Gene:
WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial) is a protein-coding gene. GO annotations related to this gene include tryptophan-tRNA ligase activity.

Gene Wiki entry for WARS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WARS2 gene promoter:
         AML1a   MEF-2   POU3F2   LCR-F1   MEF-2A   POU2F1   POU2F1b   POU2F1a   POU2F1c   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWARS2 promoter sequence
   Search Chromatin IP Primers for WARS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WARS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p12   Ensembl cytogenetic band:  1p12   HGNC cytogenetic band: 1p12

WARS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WARS2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M119573:  view genomic region     (about GC identifiers)

Start:
119,573,839 bp from pter      End:
119,683,295 bp from pter
Size:
109,457 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYWM_HUMAN, Q9UGM6 (See protein sequence)
Recommended Name: Tryptophan--tRNA ligase, mitochondrial precursor  
Size: 360 amino acids; 40147 Da
Secondary accessions: B1ALR1 B2R9D4 Q53FT4 Q5VUD2 Q86TQ0
Alternative splicing: 2 isoforms:  Q9UGM6-1   Q9UGM6-2   

Explore the universe of human proteins at neXtProt for WARS2: NX_Q9UGM6

Explore proteomics data for WARS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for WARS2 (Q9UGM6) (see all 5)
     LGNYLGA  KMSKSDP  AADILLY  VPVGEDQ 


    See WARS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_056651.1  NP_957715.1  

    ENSEMBL proteins: 
     ENSP00000358434   ENSP00000235521   ENSP00000438807  
    Reactome Protein details: Q9UGM6

    WARS2 Human Recombinant Protein Products:

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    Novus Biologicals WARS2 Proteins
    Novus Biologicals WARS2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for WARS2

     
    Search eBioscience for Proteins for WARS2 

    WARS2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for WARS2

    WARS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for WARS2
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    Search eBioscience for ELISAs for WARS2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    aaRS1: Aminoacyl tRNA synthetases / Class I

    5 InterPro protein domains:
     IPR002305 aa-tRNA-synth_Ic
     IPR001412 aa-tRNA-synth_I_CS
     IPR024109 Trp-tRNA-ligase_bac-type
     IPR014729 Rossmann-like_a/b/a_fold
     IPR002306 Trp-tRNA-ligase

    Graphical View of Domain Structure for InterPro Entry Q9UGM6

    ProtoNet protein and cluster: Q9UGM6

    1 Blocks protein domain: IPB002305 Aminoacyl-tRNA synthetase

    UniProtKB/Swiss-Prot: SYWM_HUMAN, Q9UGM6
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family


    Find genes that share domains with WARS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYWM_HUMAN, Q9UGM6
    Catalytic activity: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)

         Genatlas biochemistry entry for WARS2:
    tryptophanyl-tRNA synthetase 2,mitochondrial

         Enzyme Numbers (IUBMB): EC 6.1.1.21 2 EC 6.1.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004830tryptophan-tRNA ligase activity IEA--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with WARS2           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Wars2 (no phenotypes)

    Find genes that share phenotypes with WARS2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WARS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WARS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WARS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WARS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target WARS2:
    hsa-let-7b-5p (MIRT032492), hsa-mir-98-5p (MIRT027840)

    Block miRNA regulation of human, mouse, rat WARS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WARS2 (see all 21):
    hsa-miR-320a hsa-let-7d hsa-let-7c hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-508-5p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidWARS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WARS2
    Predesigned siRNA for gene silencing in human, mouse, rat WARS2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for WARS2 (see all 12)
    OriGene ORF clones in mouse, rat for WARS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): WARS2 (NM_201263)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WARS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WARS2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for WARS2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WARS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYWM_HUMAN, Q9UGM6: Mitochondrion matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix TAS--

    Find genes that share ontologies with WARS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WARS2 About    
    See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Mitochondrial tRNA aminoacylation0.50
    Aminoacyl-tRNA biosynthesis0.52
    2Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with WARS2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for WARS2
        Mitochondrial tRNA aminoacylation


    1 Kegg Pathway  (Kegg details for WARS2):
        Aminoacyl-tRNA biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WARS2
    Interactions:

        GeneGlobe Interaction Network for WARS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for WARS2 (Q9UGM63 ENSP000002355214) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPD1P108093, ENSP000003400194I2D: score=2 STRING: ENSP00000340019
    CADP277083, ENSP000002647054I2D: score=1 STRING: ENSP00000264705
    ABCD2Q9UBJ23I2D: score=1 
    ANAPC2Q9UJX63I2D: score=1 
    HDAC1Q135473I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis IEA--
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006436tryptophanyl-tRNA aminoacylation IEA--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with WARS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WARS2 (SYWM)

    5 HMDB Compounds for WARS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Tryptophan(-)-tryptophan (see all 53)73-22-3--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for WARS2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Tryptophan(-)-Tryptophan (see all 14)73-22-3targetinhibitor16724112 16636268 16639024 17428498 17114825
    enzymesubstrate inhibitor16724112 16636268 16639024 17428498 17114825 16724112 16636268 16639024 17428498 17114825

    4 Novoseek inferred chemical compound relationships for WARS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trna(trp) 89.3 3 11600701 (2), 7743129 (1)
    aminoacyl-trna 75.4 3 7743129 (1), 8643392 (1), 12438642 (1)
    trna 55.9 4 7743129 (1), 8643392 (1), 17637340 (1)
    atp 15.8 2 7743129 (1), 19477411 (1)



    Find genes that share compounds with WARS2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WARS2 gene (2 alternative transcripts): 
    NM_015836.3  NM_201263.2  

    Unigene Cluster for WARS2:

    Tryptophanyl tRNA synthetase 2, mitochondrial
    Hs.523506  [show with all ESTs]
    Unigene Representative Sequence: BC039889
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369426(uc010oxf.2 uc001ehm.3) ENST00000235521(uc001ehn.3 uc010oxg.2 uc010oxh.2)
    ENST00000495746 ENST00000497402 ENST00000497761 ENST00000537870(uc010oxi.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat WARS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WARS2 (see all 21):
    hsa-miR-320a hsa-let-7d hsa-let-7c hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-508-5p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidWARS2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WARS2
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): WARS2 (NM_201263)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WARS2
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      QuantiTect SYBR Green Assays in human, mouse, rat WARS2
      QuantiFast Probe-based Assays in human, mouse, rat WARS2

    Additional mRNA sequence: 

    AJ242739.1 AK056365.1 AK223197.1 AK296088.1 AK296799.1 AK299547.1 AK300295.1 AK313740.1 
    BC021722.1 BC037821.2 BC039889.1 BC044575.1 

    10 DOTS entries:

    DT.97840154  DT.95270607  DT.313244  DT.444801  DT.91854676  DT.91744934  DT.97840153  DT.100813783 
    DT.121449946  DT.101956725 

    Selected AceView cDNA sequences (see all 137):

    BM985401 AA194238 Z40749 NM_201263 BQ014588 BP336381 BF438361 BF447233 
    BU181461 CR599172 AW068958 NM_015836 BU629288 CR590727 AL519147 CR621696 
    BC039889 BE394734 BQ432000 BM802067 BM834499 AW195495 BE275735 BX355579 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for WARS2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                    -                                             
    SP2:                    -           -           -                     
    SP3:                                                                  


    ECgene alternative splicing isoforms for WARS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WARS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTAAAGGAA
    WARS2 Expression
    About this image


    WARS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
    WARS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WARS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523506
        Custom PCR Arrays for WARS2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for WARS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WARS2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WARS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WARS2 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wars21 , 5 tryptophanyl tRNA synthetase 2 (mitochondrial)1, 5 85.37(n)1
    86.39(a)1
      3 (43.03 cM)5
    705601  NM_027462.41  NP_081738.21 
     991410685 
    chicken
    (Gallus gallus)
    Aves WARS21 tryptophanyl tRNA synthetase 2, mitochondrial 67.72(n)
    67.46(a)
      418312  XM_416536.4  XP_416536.4 
    lizard
    (Anolis carolinensis)
    Reptilia WARS26
    tryptophanyl tRNA synthetase 2, mitochondrial
    69(a)
    1 ↔ 1
    GL343218.1(550391-577260)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.65832 Xenopus laevis transcribed sequence with weak similarity more 75.63(n)    BJ067886.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb77g082 wufb77g08 76.49(n)   322959  AL914927.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74411 , 3 tryptophan-tRNA ligase3
    CG74411
    52(a)3
    55.14(n)1
    52.78(a)1
      399891  NM_140761.31  NP_649018.21 
    worm
    (Caenorhabditis elegans)
    Secernentea wrs-23
    prx-101
    prx-101 42(a)3
    48.65(n)1
    44.06(a)1
      III(5308215-5311711)3
    1757191  NM_001026030.31  NP_001021201.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSW1(YDR268W)4
    MSW11
    Mitochondrial tryptophanyl-tRNA synthetase4
    MSW11
    48.93(n)1
    43.73(a)1
      4(1004004-1005143)4
    8518611, 4  NP_010554.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons OVA41 OVA4 49.95(n)
    40.92(a)
      817126  NM_201804.3  NP_973533.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g07434001 Os01g0743400 48.31(n)
    41.16(a)
      4326551  NM_001050753.1  NP_001044218.1 


    ENSEMBL Gene Tree for WARS2 (if available)
    TreeFam Gene Tree for WARS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WARS2 gene

    Find genes that share paralogs with WARS2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for WARS2
    PGOHUM00000258497


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WARS2 (see all 1951)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1832113571,2
    --119573859(+) TACCTG/TTAGTT 2 -- ut310--------
    rs120861,2
    C,F,H--119573860(+) ACCTTT/CAGTTT 2 -- ut31 ese321Minor allele frequency- C:0.12NA NS EA WA 2474
    rs1879008451,2
    --119573963(+) ACTTAC/GAGACA 2 -- ut310--------
    rs89281,2
    C,F,A,H--119574074(-) ACGCCG/CCATCC 2 -- ut31 ese321Minor allele frequency- C:0.27MN NA NS EA WA CSA 1342
    rs1473085081,2
    --119574103(+) TTCTGA/GCACAA 2 -- ut310--------
    rs1907039701,2
    --119574106(+) TGACAC/TAAGGA 2 -- ut310--------
    rs1829492381,2
    --119574116(+) ACTACA/TCTACT 2 -- ut310--------
    rs1878454761,2
    C--119574157(+) CTCAAA/CAACCT 2 -- ut310--------
    rs1929324811,2
    --119574202(+) ACTGAC/TAAAAA 2 -- ut310--------
    rs26452931,2
    C,F,H--119574282(+) TTTTCA/TTTTTC 2 -- ut316Minor allele frequency- T:0.04NS EA WA 526

    HapMap Linkage Disequilibrium report for WARS2 (119573839 - 119683295 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for WARS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2475310CNV Deletion19546169
    nsv521813CNV Loss19592680
    dgv16n21CNV Loss19592680
    nsv524681CNV Gain19592680
    nsv831192CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WARS2
    DNA2.0 Custom Variant and Variant Library Synthesis for WARS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604733    OMIM disorders: --


    Find genes that share disorders with WARS2           About GenesLikeMe

    Genetic Association Database (GAD): WARS2
    Human Genome Epidemiology (HuGE) Navigator: WARS2 (2 documents)

    Export disorders for WARS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WARS2 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with WARS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase. (PubMed id 10828066)1, 2, 3, 9 Jorgensen R....Justesen J. (J. Biol. Chem. 2000)
    2. Assignment of the human mitochondrial tryptophanyl-tRNA synthetase (WARS2) to 1p13.3--&gt;p13.1 by radiation hybrid mapping. (PubMed id 10072595)1, 3, 9 Martinez-Dominguez M.T....Hansen L.L. (Cytogenet. Cell Genet. 1998)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. (PubMed id 20935629)1 Heid I.M....Lindgren C.M. (Nat. Genet. 2010)
    10. Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311. (PubMed id 17726052)1 Guo L.T....Jin Y.X. (Nucleic Acids Res. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10352 HGNC: 12730 AceView: WARS2 Ensembl:ENSG00000116874 euGenes: HUgn10352
    ECgene: WARS2 Kegg: 10352 H-InvDB: WARS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WARS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WARS2 gene:
    Search GeneIP for patents involving WARS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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