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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WAPAL Gene

protein-coding   GIFtS: 58
GCID: GC10M088185

Wings Apart-Like Homolog (Drosophila)

(Previous name: KIAA0261)
(Previous symbol: KIAA0261)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Wings Apart-Like Homolog (Drosophila)1 2     Friend Of EBNA2 Protein2 3
KIAA02611 2 3 5     Friend Of EBNA21
FOE2 3 5     Friend Of EBNA2 (Epstein-Barr Virus Nuclear Protein 2)2
WAPL2 3 5     Wings Apart-Like Protein Homolog2

External Ids:    HGNC: 232931   Entrez Gene: 230632   Ensembl: ENSG000000626507   OMIM: 6107545   UniProtKB: Q7Z5K23   

Export aliases for WAPAL gene to outside databases

Previous GC identifer: GC10M082045


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for WAPAL Gene: 
WAPAL (wings apart-like homolog (Drosophila)) is a protein-coding gene. Diseases associated with WAPAL include mu chain disease, and cervicitis, and among its related super-pathways are Mitotic Anaphase and Cohesin Loading onto Chromatin. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: WAPL_HUMAN, Q7Z5K2
Function: Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with
chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during
early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome
partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair

Gene Wiki entry for WAPAL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WAPAL gene promoter:
         Sox5   AML1a   Pax-5   POU3F1   p300   POU6F1 (c2)   c-Ets-1   AREB6   FOXC1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWAPAL promoter sequence
   Search SABiosciences Chromatin IP Primers for WAPAL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WAPAL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.2   Ensembl cytogenetic band:  10q23.2   HGNC cytogenetic band: 10q23.31

WAPAL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WAPAL gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M088185:  view genomic region     (about GC identifiers)

Start:
88,195,013 bp from pter      End:
88,281,572 bp from pter
Size:
86,560 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WAPL_HUMAN, Q7Z5K2 (See protein sequence)
Recommended Name: Wings apart-like protein homolog  
Size: 1190 amino acids; 132946 Da
Subunit: Interacts with the cohesin complex throughout the cell cycle; interacts with both chromatin-bound and
soluble pools of the complex. Interacts with RAD21; the interaction is direct. Interacts with PDS5A; the
interaction is direct, cohesin-dependent and competitive with SORORIN. Interacts (via FGF motifs) with PDS5B; the
interaction is direct. Interacts with SMC3. Isoform 2 interacts with Epstein-Barr virus EBNA2
Subcellular location: Isoform 2: Nucleus
Subcellular location: Nucleus. Chromosome. Cytoplasm. Note=Associates with chromatin through the cohesin complex
during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in
nucleus at telophase
Sequence caution: Sequence=BAA13391.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAH73376.1; Type=Erroneous gene model prediction; Sequence=CAI16708.1; Type=Erroneous gene model
prediction;
Secondary accessions: A7E2B5 Q5VSK5 Q8IX10 Q92549
Alternative splicing: 3 isoforms:  Q7Z5K2-1   Q7Z5K2-2   Q7Z5K2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WAPAL: NX_Q7Z5K2

Explore proteomics data for WAPAL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z5K2

  • WAPAL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WAPAL Protein Expression
    REFSEQ proteins: NP_055860.1  
    ENSEMBL proteins: 
     ENSP00000298767   ENSP00000361145   ENSP00000263070  
    Reactome Protein details: Q7Z5K2
    Human Recombinant Protein Products for WAPAL: 
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    Cloud-Clone Corp. Proteins for WAPAL 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region TAS--
    GO:0000785chromatin IDA17113138
    GO:0000795synaptonemal complex IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--

    WAPAL for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR012502 WAPL_metazoan_plants
     IPR022771 WAPL_prot
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q7Z5K2

    ProtoNet protein and cluster: Q7Z5K2

    1 Blocks protein domain: IPB012502 Wings apart-like

    UniProtKB/Swiss-Prot: WAPL_HUMAN, Q7Z5K2
    Similarity: Belongs to the WAPL family
    Similarity: Contains 1 WAPL domain


    WAPAL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WAPL_HUMAN, Q7Z5K2
    Function: Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with
    chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during
    early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome
    partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI17112726
         
    WAPAL for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WAPAL 
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    SwitchGear 3'UTR luciferase reporter plasmidWAPAL 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WAPAL About                                                                                                See pathways by source

    SuperPathContained pathways About
    1M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    2Cohesin Loading onto Chromatin
    Cohesin Loading onto Chromatin0.71
    Establishment of Sister Chromatid Cohesion0.62
    Mitotic Telophase/Cytokinesis0.71
    3Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion0.93
    Mitotic Prometaphase0.93
    4Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    5CDK-mediated phosphorylation and removal of Cdc6
    S Phase0.79

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/13        Reactome Pathways for WAPAL (see all 13)
        Mitotic Metaphase and Anaphase
    Establishment of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Mitotic Anaphase



    WAPAL for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WAPAL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/603 Interacting proteins for WAPAL (Q7Z5K21, 2, 3 ENSP000002987674) via UniProtKB, MINT, STRING, and/or I2D (see all 603)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMC3Q9UQE72, 3, ENSP000003547204MINT-7945693 I2D: score=3 STRING: ENSP00000354720
    STAG1Q8WVM72, 3, ENSP000003726894MINT-7945693 I2D: score=3 STRING: ENSP00000372689
    ARAP1Q96P482, 3, ENSP000003772334MINT-7945693 I2D: score=1 STRING: ENSP00000377233
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7945693 I2D: score=1 STRING: ENSP00000326261
    RAD21O602161, 2, 3, ENSP000002973384EBI-1022242,EBI-80739 MINT-7945693 I2D: score=4 STRING: ENSP00000297338
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0000910cytokinesis ----
    GO:0007067mitosis IEA--
    GO:0008156negative regulation of DNA replication IMP19907496
    GO:0009636response to toxic substance IEA--

    WAPAL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

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    Search CenterWatch for drugs/clinical trials and news about WAPAL / WAPL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WAPAL gene: 
    NM_015045.2  

    Unigene Clusters for WAPAL:

    Wings apart-like homolog (Drosophila)
    Hs.203099  [show with all ESTs], Hs.714876
    Unigene Representative Sequences: AB065003, R99673
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484070 ENST00000298767(uc001kdn.3 uc001kdo.3 uc009xsw.3 uc010qmj.1)
    ENST00000372075 ENST00000495124 ENST00000489996 ENST00000263070

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    SwitchGear 3'UTR luciferase reporter plasmidWAPAL 3' UTR sequence
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    Additional mRNA sequence: AB426836.1 

    12 DOTS entries:

    DT.100804691  DT.95178571  DT.317564  DT.100795230  DT.95069768  DT.100795231  DT.95069767  DT.100795229 
    DT.100795228  DT.92434415  DT.95069764  DT.100795227 

    24/272 AceView cDNA sequences (see all 272):

    AA748902 CB218952 AW130069 CB243232 AA553950 CA443915 BX355642 CB125602 
    D87450 AW237620 AI830404 BM504085 AF479418 AL044549 AI005540 BE464463 
    AA504734 AI628928 BM478100 BU902195 AI434763 AA583298 BF434942 BX344489 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for WAPAL    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b ·
    SP1:                                      -     -                                                     -                                                         
    SP2:                          -           -     -                                                     -                                                         
    SP3:                                                                                                  -                 -     -                                 
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for WAPAL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WAPAL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTATGTCT
    WAPAL Expression
    About this image


    See WAPAL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WAPAL

    SOURCE GeneReport for Unigene clusters: Hs.203099 Hs.714876

    UniProtKB/Swiss-Prot: WAPL_HUMAN, Q7Z5K2
    Tissue specificity: Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a
    high level in skeletal muscle and heart

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WAPAL gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wapal1 , 5 wings apart-like homolog (Drosophila)1, 5 91.29(n)1
    93.61(a)1
      14 (20.84 cM)5
    2189141  NM_001004436.31  NP_001004436.21 
     346739285 
    chicken
    (Gallus gallus)
    Aves WAPAL1 wings apart-like homolog (Drosophila) 80.1(n)
    82.29(a)
      423608  NM_001199511.1  NP_001186440.1 
    lizard
    (Anolis carolinensis)
    Reptilia WAPAL6
    wings apart-like homolog (Drosophila)
    78(a)
    1 ↔ 1
    GL343368.1(846765-905175)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ032159.12   -- 82.56(n)    BJ032159.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM775252.12   -- 78.62(n)    BM775252.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wapl6
    wings apart-like
    16(a)
    1 ↔ 1
    X(2044135-2053016)
    worm
    (Caenorhabditis elegans)
    Secernentea wapl-11 Protein WAPL-1 42.8(n)
    31.94(a)
      177211  NM_068166.4  NP_500567.1 


    ENSEMBL Gene Tree for WAPAL (if available)
    TreeFam Gene Tree for WAPAL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1798 SNPs in WAPAL are shown (see all 1798)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs792271391,2
    Cuntested188260361(+) AACTGG/AGAGTT 2 /S syn11Minor allele frequency- A:0.50NA 2
    rs719106041,2
    C--88194515(+) TGATT-/TGTC  
            
    TTTCT
    1 -- ds50010--------
    rs1443513751,2
    --88194524(+) TTTCTA/GTATCC 1 -- ds50010--------
    rs49342071,2
    C,F,A,H--88194529(+) ATATCT/CATAGC 1 -- ds500125Minor allele frequency- C:0.36NS EA NA WA CSA 2768
    rs1912850461,2
    --88194559(+) TTACTC/GATGTT 1 -- ds50010--------
    rs1148037281,2
    C,F--88194683(+) CTGACA/GATTAA 1 -- ds50011Minor allele frequency- G:0.05WA 118
    rs1132787881,2
    C,F--88194712(+) AAAAAG/ACAGTG 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1885952281,2
    --88194717(+) GCAGTA/GTAAAA 1 -- ds50010--------
    rs1811769151,2
    --88194842(+) TTGTTA/GAGTTC 1 -- ds50010--------
    rs1853932171,2
    --88194863(+) CAGATA/GAGTAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for WAPAL (88195013 - 88281572 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for WAPAL:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv7480CNV Insertion18451855
    nsv7478CNV Insertion18451855
    esv1003241CNV Insertion20482838
    esv1688003CNV Insertion17803354
    nsv509361CNV Insertion20534489
    nsv895832CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610754    OMIM disorders: --

    3 diseases for WAPAL:    About MalaCards
    mu chain disease    cervicitis    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for WAPAL:
    Mu chain disease

    WAPAL for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): WAPAL
    Human Genome Epidemiology (HuGE) Navigator: WAPAL (2 documents)

    Export disorders for WAPAL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WAPAL gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with WAPAL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. (PubMed id 17112726)1, 2, 3 Gandhi R....Hirano T. (2006)
    2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2, 3 Nagase T....Nomura N. (1996)
    3. Identification and cloning of a novel chromatin-associated protein partner of Epstein-Barr nuclear protein 2. (PubMed id 15383329)1, 2, 9 Kwiatkowski B.A.... Schubach W.H. (2004)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Sororin mediates sister chromatid cohesion by antagonizing wapl. (PubMed id 21111234)1, 2 Nishiyama T....Peters J.M. (2010)
    6. Releasing cohesin from chromosome arms in early mitos is: opposing actions of Wapl-Pds5 and Sgo1. (PubMed id 19696148)1, 2 Shintomi K. and Hirano T. (2009)
    7. Cohesin acetylation speeds the replication fork. (PubMed id 19907496)1, 2 Terret M.E....Jallepalli P.V. (2009)
    8. Wapl controls the dynamic association of cohesin with chromatin. (PubMed id 17113138)1, 2 Kueng S....Peters J.M. (2006)
    9. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23063 HGNC: 23293 AceView: KIAA0261 Ensembl:ENSG00000062650 euGenes: HUgn23063
    ECgene: WAPAL H-InvDB: WAPAL

    (According to HUGE)
    About This Section
    HUGE: KIAA0261

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WAPAL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WAPAL gene:
    Search GeneIP for patents involving WAPAL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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