Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WAPAL Gene

Aliases for WAPAL Gene

  • Wings Apart-Like Homolog (Drosophila) 2 3
  • KIAA0261 2 3 4 6
  • WAPL 3 4 6
  • FOE 3 4 6
  • Friend Of EBNA2 Protein 3 4
  • Friend Of EBNA2 (Epstein-Barr Virus Nuclear Protein 2) 3
  • Wings Apart-Like Protein Homolog 3
  • Friend Of EBNA2 2

External Ids for WAPAL Gene

Previous HGNC Symbols for WAPAL Gene

  • KIAA0261

Previous GeneCards Identifiers for WAPAL Gene

  • GC10M088185
  • GC10M082045

Summaries for WAPAL Gene

GeneCards Summary for WAPAL Gene

WAPAL (Wings Apart-Like Homolog (Drosophila)) is a Protein Coding gene. Diseases associated with WAPAL include mu chain disease. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for WAPAL Gene

  • Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.

Gene Wiki entry for WAPAL Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WAPAL Gene

Genomics for WAPAL Gene

Regulatory Elements for WAPAL Gene

Genomic Location for WAPAL Gene

Start:
86,435,256 bp from pter
End:
86,521,821 bp from pter
Size:
86,566 bases
Orientation:
Minus strand

Genomic View for WAPAL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WAPAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WAPAL Gene

Proteins for WAPAL Gene

  • Protein details for WAPAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5K2-WAPL_HUMAN
    Recommended name:
    Wings apart-like protein homolog
    Protein Accession:
    Q7Z5K2
    Secondary Accessions:
    • A7E2B5
    • Q5VSK5
    • Q8IX10
    • Q92549

    Protein attributes for WAPAL Gene

    Size:
    1190 amino acids
    Molecular mass:
    132946 Da
    Quaternary structure:
    • Interacts with the cohesin complex throughout the cell cycle; interacts with both chromatin-bound and soluble pools of the complex. Interacts with RAD21; the interaction is direct. Interacts with PDS5A; the interaction is direct, cohesin-dependent and competitive with CDCA5/SORORIN. Interacts (via FGF motifs) with PDS5B; the interaction is direct. Interacts with a SMC1 protein (SMC1A or SMC1B) and SMC3. Isoform 2 interacts with Epstein-Barr virus EBNA2.
    SequenceCaution:
    • Sequence=BAA13391.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH73376.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16708.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for WAPAL Gene

    Alternative splice isoforms for WAPAL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WAPAL Gene

Proteomics data for WAPAL Gene at MOPED

Post-translational modifications for WAPAL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WAPAL Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for WAPAL Gene

Domains for WAPAL Gene

Protein Domains for WAPAL Gene

Suggested Antigen Peptide Sequences for WAPAL Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z5K2

UniProtKB/Swiss-Prot:

WAPL_HUMAN :
  • Q7Z5K2
Domain:
  • Contains 1 WAPL domain.
Family:
  • Belongs to the WAPL family.
genes like me logo Genes that share domains with WAPAL: view

No data available for Gene Families for WAPAL Gene

Function for WAPAL Gene

Molecular function for WAPAL Gene

UniProtKB/Swiss-Prot Function: Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.

Gene Ontology (GO) - Molecular Function for WAPAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 17112726
genes like me logo Genes that share ontologies with WAPAL: view

Phenotypes for WAPAL Gene

genes like me logo Genes that share phenotypes with WAPAL: view

miRNA for WAPAL Gene

miRTarBase miRNAs that target WAPAL

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WAPAL Gene

Localization for WAPAL Gene

Subcellular locations from UniProtKB/Swiss-Prot for WAPAL Gene

Isoform 2: Nucleus.
Nucleus. Chromosome. Cytoplasm. Note=Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WAPAL Gene COMPARTMENTS Subcellular localization image for WAPAL gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4

Gene Ontology (GO) - Cellular Components for WAPAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region TAS --
GO:0000785 chromatin IDA 17113138
GO:0000795 synaptonemal complex IEA --
GO:0005634 nucleus IDA 17113138
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with WAPAL: view

Pathways for WAPAL Gene

genes like me logo Genes that share pathways with WAPAL: view

Pathways by source for WAPAL Gene

Gene Ontology (GO) - Biological Process for WAPAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0008156 negative regulation of DNA replication IMP 19907496
GO:0009636 response to toxic substance IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with WAPAL: view

Transcripts for WAPAL Gene

Unigene Clusters for WAPAL Gene

Wings apart-like homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WAPAL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b ·
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:
SP5:

ExUns: 21c
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for WAPAL Gene

GeneLoc Exon Structure for
WAPAL
ECgene alternative splicing isoforms for
WAPAL

Expression for WAPAL Gene

mRNA expression in normal human tissues for WAPAL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WAPAL Gene

SOURCE GeneReport for Unigene cluster for WAPAL Gene Hs.203099

mRNA Expression by UniProt/SwissProt for WAPAL Gene

Q7Z5K2-WAPL_HUMAN
Tissue specificity: Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart.
genes like me logo Genes that share expressions with WAPAL: view

No data available for mRNA differential expression in normal tissues for WAPAL Gene

Orthologs for WAPAL Gene

This gene was present in the common ancestor of animals.

Orthologs for WAPAL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WAPAL 35
  • 99.51 (n)
  • 99.3 (a)
WAPAL 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WAPAL 35
  • 93.26 (n)
  • 95.62 (a)
WAPAL 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WAPAL 35
  • 94.29 (n)
  • 95.97 (a)
WAPAL 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wapal 35
  • 91.29 (n)
  • 93.61 (a)
Wapal 16
Wapal 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WAPAL 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 97 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Wapal 35
  • 91.4 (n)
  • 93.53 (a)
chicken
(Gallus gallus)
Aves WAPAL 35
  • 79.96 (n)
  • 81.96 (a)
WAPAL 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WAPAL 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3158 35
wapal 35
  • 71.89 (n)
  • 73.18 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3357 35
zebrafish
(Danio rerio)
Actinopterygii wapala 35
  • 65.23 (n)
  • 69.85 (a)
wapala 36
  • 59 (a)
OneToMany
wapalb 36
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta wapl 36
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea wapl-1 35
  • 42.79 (n)
  • 31.44 (a)
wapl-1 36
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
CSA.5314 36
  • 28 (a)
OneToMany
Species with no ortholog for WAPAL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WAPAL Gene

ENSEMBL:
Gene Tree for WAPAL (if available)
TreeFam:
Gene Tree for WAPAL (if available)

Paralogs for WAPAL Gene

No data available for Paralogs for WAPAL Gene

Variants for WAPAL Gene

Sequence variations from dbSNP and Humsavar for WAPAL Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs15299 -- 86,435,344(-) GGCAG(A/G)AAAAA utr-variant-3-prime
rs1184942 -- 86,469,275(-) actcc(A/C/G)tctca intron-variant
rs1896512 -- 86,439,400(-) AGAGG(C/T)GTACT intron-variant
rs1896513 -- 86,435,893(-) TACCC(A/G)TAAAA utr-variant-3-prime
rs1917160 -- 86,523,065(-) CCCCG(A/G)TTATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WAPAL Gene

Variant ID Type Subtype PubMed ID
nsv895832 CNV Gain 21882294
nsv7478 CNV Insertion 18451855
nsv509361 CNV Insertion 20534489
nsv7480 CNV Insertion 18451855
esv1003241 CNV Insertion 20482838
esv1688003 CNV Insertion 17803354

Relevant External Links for WAPAL Gene

HapMap Linkage Disequilibrium report
WAPAL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WAPAL Gene

Disorders for WAPAL Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for WAPAL Gene including...

Search for WAPAL Gene in MalaCards »

(1) University of Copenhagen DISEASES for WAPAL Gene

Relevant External Links for WAPAL

Genetic Association Database (GAD)
WAPAL
Human Genome Epidemiology (HuGE) Navigator
WAPAL
genes like me logo Genes that share disorders with WAPAL: view

No data available for UniProtKB/Swiss-Prot for WAPAL Gene

Publications for WAPAL Gene

  1. Identification and cloning of a novel chromatin-associated protein partner of Epstein-Barr nuclear protein 2. (PMID: 15383329) Kwiatkowski B.A. … Schubach W.H. (Exp. Cell Res. 2004) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4
  3. Human Wapl is a cohesin-binding protein that promotes sister- chromatid resolution in mitotic prophase. (PMID: 17112726) Gandhi R. … Hirano T. (Curr. Biol. 2006) 2 3 4
  4. Wapl controls the dynamic association of cohesin with chromatin. (PMID: 17113138) Kueng S. … Peters J.M. (Cell 2006) 3 4
  5. Expression of various types of alternatively spliced WAPL transcripts in human cervical epithelia. (PMID: 18662753) Oikawa K. … Kuroda M. (Gene 2008) 3 23

Products for WAPAL Gene

Sources for WAPAL Gene

Back to Top

Content