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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WAPAL Gene

protein-coding   GIFtS: 55
GCID: GC10M088185

wings apart-like homolog (Drosophila)

(Previous name: KIAA0261 )
(Previous symbol: KIAA0261)
 Explore 2 diseases affiliated with
WAPAL via
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Biological research products
for WAPAL    

Aliases
for WAPAL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Wings Apart-Like Homolog (Drosophila)1 2     Friend Of EBNA2 Protein2 3
FOE1 2 3 5     Friend Of EBNA2 (Epstein-Barr Virus Nuclear Protein 2)2
KIAA02611 2 3 5     Wings Apart-Like Protein Homolog2
WAPL1 2 3 5     

External Ids:    HGNC: 232931   Entrez Gene: 230632   Ensembl: ENSG000000626507   OMIM: 6107545   UniProtKB: Q7Z5K23   

Export aliases for WAPAL gene to outside databases

Previous GC identifer: GC10M082045


Summaries
for WAPAL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: WAPL_HUMAN, Q7Z5K2
Function: Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with
chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early
stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning
is accurate in both meiotic and mitotic cells and plays an important role in DNA repair

Gene Wiki entry for WAPAL


Genomic Views
for WAPAL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WAPAL gene promoter:
         Sox5   AML1a   Pax-5   POU3F1   p300   POU6F1 (c2)   c-Ets-1   AREB6   FOXC1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WAPAL promoter sequence
   Search SABiosciences Chromatin IP Primers for WAPAL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WAPAL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.2   Ensembl cytogenetic band:  10q23.2   HGNC cytogenetic band: 10q23.31

WAPAL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WAPAL gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M088185:  view genomic region     (about GC identifiers)

Start:
 88,195,013 bp from pter      End:
 88,281,572 bp from pter
Size:
 86,560 bases      Orientation:
 minus strand

Proteins
for WAPAL gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WAPL_HUMAN, Q7Z5K2 (See protein sequence)
Recommended Name: Wings apart-like protein homolog  
Size: 1190 amino acids; 132946 Da
Subunit: Interacts with the cohesin complex throughout the cell cycle; interacts with both chromatin-bound and soluble
pools of the complex. Interacts with RAD21; the interaction is direct. Interacts with PDS5A; the interaction is
direct, cohesin-dependent and competitive with SORORIN. Interacts (via FGF motifs) with PDS5B; the interaction is
direct. Interacts with SMC3. Isoform 2 interacts with Epstein-Barr virus EBNA2
Subcellular location: Isoform 2: Nucleus
Subcellular location: Nucleus. Chromosome. Cytoplasm. Note=Associates with chromatin through the cohesin complex during
interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at
telophase
Sequence caution: Sequence=BAA13391.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAH73376.1; Type=Erroneous gene model prediction; Sequence=CAI16708.1; Type=Erroneous gene model prediction;
Secondary accessions: A7E2B5 Q5VSK5 Q8IX10 Q92549
Alternative splicing: 3 isoforms:  Q7Z5K2-1   Q7Z5K2-2   Q7Z5K2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WAPAL: NX_Q7Z5K2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7Z5K2

    • WAPAL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055860.1  
    ENSEMBL proteins: 
     ENSP00000345162   ENSP00000361145   ENSP00000298767   ENSP00000263070  
    Reactome Protein details: Q7Z5K2
    Human Recombinant Protein Products: 
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    Uscn Proteins for WAPAL

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IDA19696148
    GO:0000795synaptonemal complex IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA17113138


    WAPAL for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for WAPAL gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WAPAL for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR012502 WAPL_metazoan_plants
     IPR022771 WAPL_prot
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q7Z5K2

    ProtoNet protein and cluster: Q7Z5K2

    1 Blocks protein family: IPB012502 Wings apart-like

    UniProtKB/Swiss-Prot: WAPL_HUMAN, Q7Z5K2
    Similarity: Belongs to the WAPL family
    Similarity: Contains 1 WAPL domain


    Function
    for WAPAL gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: WAPL_HUMAN, Q7Z5K2
    Function: Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with
    chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early
    stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning
    is accurate in both meiotic and mitotic cells and plays an important role in DNA repair

    miRNA
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    8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate WAPAL (see all 83):
    hsa-miR-582-3p hsa-miR-300 hsa-miR-199a-3p hsa-miR-15a hsa-miR-200a hsa-miR-3921 hsa-miR-1244 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmid: WAPAL 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    WAPAL for ontologies           About GeneDecksing



    Pathways & Interactions
    for WAPAL gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1M Phase
    		M Phase1.00
    		Mitotic Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Separation of Sister Chromatids0.80
    		Mitotic Metaphase and Anaphase0.85
    2Resolution of Sister Chromatid Cohesion
    		Resolution of Sister Chromatid Cohesion1.00
    		Mitotic Prometaphase0.93
    		Kinetochore assembly0.96
    3Cohesin Loading onto Chromatin
    		Cohesin Loading onto Chromatin1.00
    		Establishment of Sister Chromatid Cohesion0.62
    		Mitotic Telophase/Cytokinesis0.71
    4Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84
    5Ubiquitinated Orc1 is degraded by the proteasome
    		S Phase0.40

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/14        Reactome Pathways for WAPAL (see all 14)
        Mitotic Metaphase and Anaphase
    Establishment of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Mitotic Anaphase



    WAPAL for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WAPAL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/575 Interacting proteins for WAPAL (Q7Z5K21, 2, 3 ENSP000002987674) via UniProtKB, MINT, STRING, and/or I2D (see all 575)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMC3Q9UQE72, 3, ENSP000003547204MINT-7945693 I2D: score=3 STRING: ENSP00000354720
    STAG1Q8WVM72, 3, ENSP000003726894MINT-7945693 I2D: score=3 STRING: ENSP00000372689
    ARAP1Q96P482, 3, ENSP000003772334MINT-7945693 I2D: score=1 STRING: ENSP00000377233
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7945693 I2D: score=1 STRING: ENSP00000326261
    RAD21O602161, 2, 3, ENSP000002973384EBI-1022242,EBI-80739 MINT-7945693 I2D: score=4 STRING: ENSP00000297338
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--
    GO:0008156negative regulation of DNA replication IMP19907496
    GO:0009636response to toxin IEA--
    GO:0019048virus-host interaction IEA--
    GO:0035562negative regulation of chromatin binding IMP17113138


    WAPAL for ontologies           About GeneDecksing



    Drugs & Compounds
    for WAPAL gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WAPAL
    Search CenterWatch for drugs/clinical trials and news about WAPAL / WAPL 

    Transcripts
    for WAPAL gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WAPAL gene: 
    NM_015045.2  

    Unigene Clusters for WAPAL:

    Wings apart-like homolog (Drosophila)
    Hs.203099  [show with all ESTs], Hs.714876
    Unigene Representative Sequences: AB065003, R99673
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342368(uc009xsv.3 uc010qmh.1 uc010qmi.1) ENST00000484070
    ENST00000372075 ENST00000495124 ENST00000489996 ENST00000298767(uc001kdn.3 uc001kdo.3 uc009xsw.3 uc010qmj.1)
    ENST00000263070

    miRNA
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    8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate WAPAL (see all 83):
    hsa-miR-582-3p hsa-miR-300 hsa-miR-199a-3p hsa-miR-15a hsa-miR-200a hsa-miR-3921 hsa-miR-1244 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmid: WAPAL 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WAPAL (see all 4)
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    Clone
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    Primer
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    Additional cDNA sequence: AB426836.1 

    12 DOTS entries:

    DT.100804691  DT.95178571  DT.317564  DT.100795230  DT.95069768  DT.100795231  DT.95069767  DT.100795229 
    DT.100795228  DT.92434415  DT.95069764  DT.100795227 

    24/272 AceView cDNA sequences (see all 272):

    AW237620 AL044549 CB125602 AI830404 BM504085 AI628928 BU189042 AW512613 
    BI916843 AI620990 AI538366 AI434763 BE218309 AA490498 AA703644 AL541053 
    CA443915 AA504734 AA747677 AI656007 CD299919 CB243232 AA682854 AA583298 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for WAPAL    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b ·
    SP1:                                      -     -                                                     -                                                         
    SP2:                          -           -     -                                                     -                                                         
    SP3:                                                                                                  -                 -     -                                 
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for WAPAL

    Expression
    for WAPAL gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WAPAL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGTATGTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    WAPAL expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Yolk SacDefinitive Yolk SacDefinitive Hematopoietic Stem CellsBlood
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See WAPAL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WAPAL

    SOURCE GeneReport for Unigene clusters: Hs.203099 Hs.714876

    UniProtKB/Swiss-Prot: WAPL_HUMAN, Q7Z5K2
    Tissue specificity: Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high
    level in skeletal muscle and heart

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    In Situ
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    Orthologs
    for WAPAL gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WAPAL gene from 9/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Wapal1 , 5 wings apart-like homolog (Drosophila)1, 5 91.29(n)1
    93.61(a)1    		   14 (20.84 cM)5
    2189141  NM_001004436.31  NP_001004436.21 
     346739285 
    chicken
    (Gallus gallus)    		 Aves WAPAL1 wings apart-like homolog (Drosophila) 80.1(n)
    82.29(a)    		   423608  NM_001199511.1  NP_001186440.1 
    lizard
    (Anolis carolinensis)    		 Reptilia WAPAL6
    		 --
    		 78(a)
    		 1 ↔ 1
    		 GL343368.1(846765-898821)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BJ032159.12   -- 82.56(n)    BJ032159.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BM775252.12   -- 78.62(n)    BM775252.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta wapl6
    		 wings apart-like
    		 15(a)
    		 1 ↔ 1
    		 X(2044135-2053016)
    worm
    (Caenorhabditis elegans)    		 Secernentea wapl-11 Protein WAPL-1 42.8(n)
    31.94(a)    		   177211  NM_068166.4  NP_500567.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G610306
    AT1G110606
    		 WAPL (Wings apart-like protein regulation of heter...
    WAPL (Wings apart-like protein regulation of heter...
    		 17(a)
    16(a)
    		 many → 1
    many → 1
    		 1(22477896-22482380)
    1(3684568-3689847)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 expressed protein
    		 16(a)
    		 1 ↔ 1
    		 10(18835080-18843887)


    ENSEMBL Gene Tree for WAPAL (if available)
    TreeFam Gene Tree for WAPAL (if available) 

    Paralogs
    for WAPAL gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for WAPAL gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1520 NCBI SNPs in WAPAL are shown (see all 1520)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs792271391,2
    		Cother88260361(+) AACTGG/AGAGTT 2 /S syn11Minor allele frequency- A:0.50NA 2
    rs719106041,2
    		C,--88194515(+) TGATT-/TGTC  
                TTTCT     		1 -- ds50010--------
    rs1443513751,2
    		--88194524(+) TTTCTA/GTATCC 1 -- ds50010--------
    rs49342071,2
    		C,F,A,H,--88194529(+) ATATCT/CATAGC 1 -- ds500125Minor allele frequency- C:0.36NS EA NA WA CSA 2768
    rs1912850461,2
    		--88194559(+) TTACTC/GATGTT 1 -- ds50010--------
    rs1148037281,2
    		F,--88194683(+) CTGACA/GATTAA 1 -- ds50011Minor allele frequency- G:0.05WA 118
    rs1132787881,2
    		--88194712(+) AAAAAG/ACAGTG 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1885952281,2
    		--88194717(+) GCAGTA/GTAAAA 1 -- ds50010--------
    rs1811769151,2
    		--88194842(+) TTGTTA/GAGTTC 1 -- ds50010--------
    rs1853932171,2
    		--88194863(+) CAGATA/GAGTAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for WAPAL (88195013 - 88281572 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for WAPAL
         3 CNVs: 34897 33930 34896

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    Disorders / Diseases
    for WAPAL gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WAPAL for disorders           About GeneDecksing

    OMIM gene information: 610754    OMIM disorders: --

    2 diseases for WAPAL:    About MalaCards
    alzheimer's disease    cervicitis

    1 disease from the University of Copenhagen DISEASES database for WAPAL:
    Mu chain disease
    Human Genome Epidemiology (HuGE) Navigator: WAPAL (2 documents)

    Export disorders for WAPAL gene to outside databases

    Publications
    for WAPAL gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WAPAL gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with WAPAL)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. (PubMed id 17112726)1, 2, 3 Gandhi R....Hirano T. (2006)
    2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2, 3 Nagase T....Nomura N. (1996)
    3. Identification and cloning of a novel chromatin-associated protein partner of Epstein-Barr nuclear protein 2. (PubMed id 15383329)1, 2, 9 Kwiatkowski B.A.... Schubach W.H. (2004)
    4. Releasing cohesin from chromosome arms in early mitos is: opposing actions of Wapl-Pds5 and Sgo1. (PubMed id 19696148)1, 2 Shintomi K. and Hirano T. (2009)
    5. Cohesin acetylation speeds the replication fork. (PubMed id 19907496)1, 2 Terret M.E....Jallepalli P.V. (2009)
    6. Wapl controls the dynamic association of cohesin with chromatin. (PubMed id 17113138)1, 2 Kueng S....Peters J.M. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression. (PubMed id 15150110)1, 2 Oikawa K.... Mukai K. (2004)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    10. Expression of various types of alternatively spliced WAPL transcripts in human cervical epithelia. (PubMed id 18662753)1, 9 Oikawa K.... Kuroda M. (2008)

    External Searches for WAPAL gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing WAPAL gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23063 HGNC: 23293 AceView: KIAA0261 Ensembl:ENSG00000062650 euGenes: HUgn23063
    ECgene: WAPAL H-InvDB: WAPAL

    Other Databases showing WAPAL gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0261

    Specialized Databases showing WAPAL gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WAPAL Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for WAPAL gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WAPAL gene:
    Search GeneIP for patents involving WAPAL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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