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WAPAL Gene

protein-coding   GIFtS: 59
GCID: GC10M088185

Wings Apart-Like Homolog (Drosophila)

(Previous name: KIAA0261)
(Previous symbol: KIAA0261)
  See WAPAL-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Wings Apart-Like Homolog (Drosophila)1 2     Friend Of EBNA2 Protein2 3
KIAA02611 2 3 5     Friend Of EBNA21
FOE2 3 5     Friend Of EBNA2 (Epstein-Barr Virus Nuclear Protein 2)2
WAPL2 3 5     Wings Apart-Like Protein Homolog2

External Ids:    HGNC: 232931   Entrez Gene: 230632   Ensembl: ENSG000000626507   OMIM: 6107545   UniProtKB: Q7Z5K23   

Export aliases for WAPAL gene to outside databases

Previous GC identifer: GC10M082045


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for WAPAL Gene:
WAPAL (wings apart-like homolog (Drosophila)) is a protein-coding gene. Diseases associated with WAPAL include mu chain disease.

UniProtKB/Swiss-Prot: WAPL_HUMAN, Q7Z5K2
Function: Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with
chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during
early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome
partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair

Gene Wiki entry for WAPAL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WAPAL gene promoter:
         Sox5   AML1a   Pax-5   POU3F1   p300   POU6F1 (c2)   c-Ets-1   AREB6   FOXC1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWAPAL promoter sequence
   Search Chromatin IP Primers for WAPAL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WAPAL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.2   Ensembl cytogenetic band:  10q23.2   HGNC cytogenetic band: 10q23.31

WAPAL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WAPAL gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M088185:  view genomic region     (about GC identifiers)

Start:
88,195,013 bp from pter      End:
88,281,572 bp from pter
Size:
86,560 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WAPL_HUMAN, Q7Z5K2 (See protein sequence)
Recommended Name: Wings apart-like protein homolog  
Size: 1190 amino acids; 132946 Da
Subunit: Interacts with the cohesin complex throughout the cell cycle; interacts with both chromatin-bound and
soluble pools of the complex. Interacts with RAD21; the interaction is direct. Interacts with PDS5A; the
interaction is direct, cohesin-dependent and competitive with CDCA5/SORORIN. Interacts (via FGF motifs) with
PDS5B; the interaction is direct. Interacts with a SMC1 protein (SMC1A or SMC1B) and SMC3. Isoform 2 interacts
with Epstein-Barr virus EBNA2
Sequence caution: Sequence=BAA13391.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAH73376.1; Type=Erroneous gene model prediction; Sequence=CAI16708.1; Type=Erroneous gene model
prediction;
1 PDB 3D structure from and Proteopedia for WAPAL:
4K6J (3D)    
Secondary accessions: A7E2B5 Q5VSK5 Q8IX10 Q92549
Alternative splicing: 3 isoforms:  Q7Z5K2-1   Q7Z5K2-2   Q7Z5K2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WAPAL: NX_Q7Z5K2

Explore proteomics data for WAPAL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WAPAL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055860.1  
    ENSEMBL proteins: 
     ENSP00000298767   ENSP00000361145   ENSP00000263070  
    Reactome Protein details: Q7Z5K2

    WAPAL Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for WAPAL 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR012502 WAPL_metazoan_plants
     IPR022771 WAPL_prot
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q7Z5K2

    ProtoNet protein and cluster: Q7Z5K2

    1 Blocks protein domain: IPB012502 Wings apart-like

    UniProtKB/Swiss-Prot: WAPL_HUMAN, Q7Z5K2
    Similarity: Belongs to the WAPL family
    Similarity: Contains 1 WAPL domain


    Find genes that share domains with WAPAL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WAPL_HUMAN, Q7Z5K2
    Function: Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with
    chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during
    early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome
    partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI17112726
         
    Find genes that share ontologies with WAPAL           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Wapal):
     cellular  mortality/aging 

    Find genes that share phenotypes with WAPAL           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WAPAL
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    miRNA
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    hsa-mir-148a-3p (MIRT025989), hsa-mir-193b-3p (MIRT041566)

    Block miRNA regulation of human, mouse, rat WAPAL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WAPAL (see all 83):
    hsa-miR-582-3p hsa-miR-300 hsa-miR-199a-3p hsa-miR-15a hsa-miR-200a hsa-miR-3921 hsa-miR-1244 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidWAPAL 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WAPAL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WAPL_HUMAN, Q7Z5K2: Isoform 2: Nucleus
    WAPL_HUMAN, Q7Z5K2: Nucleus. Chromosome. Cytoplasm. Note=Associates with chromatin through the cohesin complex
    during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in
    nucleus at telophase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region TAS--
    GO:0000785chromatin IDA17113138
    GO:0000795synaptonemal complex IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with WAPAL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WAPAL About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    4CDK-mediated phosphorylation and removal of Cdc6
    S Phase0.78
    Establishment of Sister Chromatid Cohesion0.00
    5Mitotic Telophase/Cytokinesis
    Mitotic Telophase/Cytokinesis
    Cohesin Loading onto Chromatin0.00


    Find genes that share SuperPaths with WAPAL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 Reactome Pathways for WAPAL
        Cohesin Loading onto Chromatin
    Establishment of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion
    Separation of Sister Chromatids


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WAPAL
    Interactions:

        Search GeneGlobe Interaction Network for WAPAL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WAPAL (Q7Z5K21, 2, 3 ENSP000002987674) via UniProtKB, MINT, STRING, and/or I2D (see all 602)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMC3Q9UQE72, 3, ENSP000003547204MINT-7945693 I2D: score=3 STRING: ENSP00000354720
    STAG1Q8WVM72, 3, ENSP000003726894MINT-7945693 I2D: score=3 STRING: ENSP00000372689
    ARAP1Q96P482, 3, ENSP000003772334MINT-7945693 I2D: score=1 STRING: ENSP00000377233
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7945693 I2D: score=1 STRING: ENSP00000326261
    RAD21O602161, 2, 3, ENSP000002973384EBI-1022242,EBI-80739 MINT-7945693 I2D: score=4 STRING: ENSP00000297338
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0008156negative regulation of DNA replication IMP19907496
    GO:0009636response to toxic substance IEA--
    GO:0016032viral process IEA--

    Find genes that share ontologies with WAPAL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WAPAL (WAPL)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WAPAL gene: 
    NM_015045.2  

    Unigene Cluster for WAPAL:

    Wings apart-like homolog (Drosophila)
    Hs.203099  [show with all ESTs]
    Unigene Representative Sequence: AB065003
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484070 ENST00000298767(uc001kdn.3 uc001kdo.3 uc009xsw.3 uc010qmj.1)
    ENST00000372075 ENST00000495124 ENST00000489996 ENST00000263070
    miRNA
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    Block miRNA regulation of human, mouse, rat WAPAL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WAPAL (see all 83):
    hsa-miR-582-3p hsa-miR-300 hsa-miR-199a-3p hsa-miR-15a hsa-miR-200a hsa-miR-3921 hsa-miR-1244 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidWAPAL 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WAPAL (NM_015045)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WAPAL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WAPAL
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for WAPAL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WAPAL
      QuantiTect SYBR Green Assays in human, mouse, rat WAPAL
      QuantiFast Probe-based Assays in human, mouse, rat WAPAL

    Additional mRNA sequence: 

    AB065003.1 AB426821.1 AB426822.1 AB426823.1 AB426824.1 AB426825.1 AB426826.1 AB426827.1 
    AB426828.1 AB426829.1 AB426830.1 AB426831.1 AB426832.1 AB426833.1 AB426834.1 AB426835.1 
    AF479418.1 AK000849.1 AK027005.1 AK290138.1 BC017393.1 BC036507.1 BC105991.1 BC140858.1 
    BC150269.1 D87450.1 

    12 DOTS entries:

    DT.100804691  DT.95178571  DT.317564  DT.100795230  DT.95069768  DT.100795231  DT.95069767  DT.100795229 
    DT.100795228  DT.92434415  DT.95069764  DT.100795227 

    Selected AceView cDNA sequences (see all 272):

    D87450 AA747677 BM478100 AW130069 AF479418 CD299919 AI654429 AI656007 
    AI337178 BE464463 CB125602 AI620990 BM504085 AI311541 CB243594 AI005540 
    AA682854 BI438658 CB243232 AL541053 BM687913 AI628928 AI868524 AA748902 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for WAPAL    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b ·
    SP1:                                      -     -                                                     -                                                         
    SP2:                          -           -     -                                                     -                                                         
    SP3:                                                                                                  -                 -     -                                 
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for WAPAL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WAPAL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTATGTCT
    WAPAL Expression
    About this image


    WAPAL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    WAPAL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WAPAL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.203099

    UniProtKB/Swiss-Prot: WAPL_HUMAN, Q7Z5K2
    Tissue specificity: Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a
    high level in skeletal muscle and heart

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WAPAL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WAPAL gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wapal1 , 5 wings apart-like homolog (Drosophila)1, 5 91.29(n)1
    93.61(a)1
      14 (20.84 cM)5
    2189141  NM_001004436.31  NP_001004436.21 
     346739285 
    chicken
    (Gallus gallus)
    Aves WAPAL1 wings apart-like homolog (Drosophila) 79.96(n)
    81.96(a)
      423608  NM_001199511.1  NP_001186440.1 
    lizard
    (Anolis carolinensis)
    Reptilia WAPAL6
    wings apart-like homolog (Drosophila)
    79(a)
    1 ↔ 1
    GL343368.1(846765-905175)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ032159.12   -- 82.56(n)    BJ032159.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM775252.12   -- 78.62(n)    BM775252.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wapl6
    wings apart-like
    17(a)
    1 ↔ 1
    X(2044135-2053016)
    worm
    (Caenorhabditis elegans)
    Secernentea wapl-11 wapl-1 42.79(n)
    31.44(a)
      177211  NM_068166.5  NP_500567.1 


    ENSEMBL Gene Tree for WAPAL (if available)
    TreeFam Gene Tree for WAPAL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WAPAL (see all 1798)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs792271391,2
    Cuntested188260361(+) AACTGG/AGAGTT 2 /S syn11Minor allele frequency- A:0.50NA 2
    rs719106041,2
    C--88194515(+) TGATT-/TGTC  
            
    TTTCT
    1 -- ds50010--------
    rs1443513751,2
    --88194524(+) TTTCTA/GTATCC 1 -- ds50010--------
    rs49342071,2
    C,F,A,H--88194529(+) ATATCT/CATAGC 1 -- ds500125Minor allele frequency- C:0.36NS EA NA WA CSA 2768
    rs1912850461,2
    --88194559(+) TTACTC/GATGTT 1 -- ds50010--------
    rs1148037281,2
    C,F--88194683(+) CTGACA/GATTAA 1 -- ds50011Minor allele frequency- G:0.05WA 118
    rs1132787881,2
    C,F--88194712(+) AAAAAG/ACAGTG 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1885952281,2
    --88194717(+) GCAGTA/GTAAAA 1 -- ds50010--------
    rs1811769151,2
    --88194842(+) TTGTTA/GAGTTC 1 -- ds50010--------
    rs1853932171,2
    --88194863(+) CAGATA/GAGTAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for WAPAL (88195013 - 88281572 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for WAPAL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7480CNV Insertion18451855
    nsv7478CNV Insertion18451855
    esv1003241CNV Insertion20482838
    esv1688003CNV Insertion17803354
    nsv509361CNV Insertion20534489
    nsv895832CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WAPAL
    DNA2.0 Custom Variant and Variant Library Synthesis for WAPAL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610754    OMIM disorders: --

    1 disease for WAPAL:    
    About MalaCards
    mu chain disease

    1 disease from the University of Copenhagen DISEASES database for WAPAL:
    Mu chain disease

    Find genes that share disorders with WAPAL           About GenesLikeMe

    Genetic Association Database (GAD): WAPAL
    Human Genome Epidemiology (HuGE) Navigator: WAPAL (2 documents)

    Export disorders for WAPAL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WAPAL gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with WAPAL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Wapl is a cohesin-binding protein that promotes sister- chromatid resolution in mitotic prophase. (PubMed id 17112726)1, 2, 3 Gandhi R.... Hirano T. (Curr. Biol. 2006)
    2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1996)
    3. Identification and cloning of a novel chromatin-associated protein partner of Epstein-Barr nuclear protein 2. (PubMed id 15383329)1, 2, 9 Kwiatkowski B.A.... Schubach W.H. (Exp. Cell Res. 2004)
    4. Structure of the human cohesin inhibitor Wapl. (PubMed id 23776203)1, 2 Ouyang Z.... Yu H. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Sororin mediates sister chromatid cohesion by antagonizing wapl. (PubMed id 21111234)1, 2 Nishiyama T....Peters J.M. (Cell 2010)
    7. Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1. (PubMed id 19696148)1, 2 Shintomi K. and Hirano T. (Genes Dev. 2009)
    8. Cohesin acetylation speeds the replication fork. (PubMed id 19907496)1, 2 Terret M.E.... Jallepalli P.V. (Nature 2009)
    9. Wapl controls the dynamic association of cohesin with chromatin. (PubMed id 17113138)1, 2 Kueng S.... Peters J.M. (Cell 2006)
    10. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23063 HGNC: 23293 AceView: KIAA0261 Ensembl:ENSG00000062650 euGenes: HUgn23063
    ECgene: WAPAL H-InvDB: WAPAL

    (According to HUGE)
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    HUGE: KIAA0261

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WAPAL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WAPAL gene:
    Search GeneIP for patents involving WAPAL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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