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Aliases & Descriptions for WAPAL
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| Friend of EBNA2 protein 3 | | friend of EBNA2 (Epstein-Barr virus nuclear protein 2) 2 | | wings apart-like homolog 2 | | wings apart-like homolog (Drosophila) 2 | | wings apart-like protein 2 |
|
| | Search outside databases for aliases for WAPAL gene |
Summaries for WAPAL(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: WAPL_HUMAN, Q7Z5K2Function: May play a role in cell growthGene Wiki entry for WAPAL |
Genomic Location for WAPAL
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the WAPAL gene 
Entrez Gene cytogenetic band: 10q23.2 Ensembl cytogenetic band: 10q23.2 HGNC cytogenetic band: 10q23.31WAPAL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M088185:
(about GC identifiers)
Start:
|
88,184,993 bp from pter |
End:
|
88,271,552 bp from pter |
Size:
|
86,560 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000010.9 NT_030059.12
| Proteins for WAPAL
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: WAPL_HUMAN, Q7Z5K2 (See
protein sequence)Recommended Name: Wings apart-like protein homolog Size: 1190 amino acids; 132946 Da
Subunit: Isoform 2 interacts with Epstein-Barr virus EBNA2
Subcellular location: Isoform 2: Nucleus
Sequence caution: Sequence=CAH73376.1; Type=Erroneous gene model prediction; Sequence=CAI16708.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5VSK5 Q8IX10 Q92549Alternative splicing: 3 isoforms: Q7Z5K2-1 Q7Z5K2-2 Q7Z5K2-3 (Named isoforms)Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_055860.1
ENSEMBL proteins: ENSP00000345162 ENSP00000361146 ENSP00000361145 ENSP00000298767 ENSP00000263070
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for WAPAL: Assays for WAPAL: | Protein
Domains/ Families for WAPAL(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q7Z5K2
ProtoNet protein and cluster: Q7Z5K2 1 Blocks protein family: IPB012502 Wings apart-like
UniProtKB/Swiss-Prot: WAPL_HUMAN, Q7Z5K2Similarity: Contains 1 WAPL domain | Gene Function for WAPAL
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_290471
Applied Biosystems Silencer® siRNAs for WAPAL
Sigma-Aldrich siRNA for WAPAL  Sigma-Aldrich shRNA for WAPAL  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015045                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015045                                  untagged cDNA clone in CMV expression vector: NM_015045 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015045
UniProtKB/Swiss-Prot: WAPL_HUMAN, Q7Z5K2Function: May play a role in cell growth1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for WAPAL
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for WAPAL (Q7Z5K21 ENSP000003451623) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0044419 | interspecies interaction between organisms |
IEA | -- | About this table
|
Drugs & Compounds for WAPAL(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for WAPAL
|
Transcripts for WAPAL(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_290471
Sigma-Aldrich siRNA for WAPAL  Sigma-Aldrich shRNA for WAPAL  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_015045 REFSEQ mRNAs for WAPAL gene: NM_015045.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015045               OriGene GFP tagged cDNA clone in CMV expression vector: NM_015045                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015045                                  untagged cDNA clone in CMV expression vector: NM_015045  Additional cDNA sequence: AB426836.1 12 DOTS entries: DT.100804691 DT.95178571 DT.317564 DT.100795230 DT.95069768 DT.100795231 DT.95069767 DT.100795229 DT.100795228 DT.92434415 DT.95069764 DT.100795227 24/272 AceView cDNA sequences (see all 272
):AW512613 AW237620 BM504085 AI127633 AI469993 AI337178 AF479418 AA630197 AA583298 AA703644 AI654429 AI311541 AA325842 AI628928 AI005540 AA748902 CB243594 BM478100 AI434763 AW130069 CB218952 BX344489 AI830404 AA682854
highest scoring ESTs for WAPAL:AA772785 AB065003 AF479418 D87450 AA195661 AA195774 AA233730 AA249352 AA281581 AA281866 Unigene Clusters for WAPAL: Wings apart-like homolog (Drosophila) Hs.203099 [show with all ESTs], Hs.714876 Unigene Representative Sequences: AB065003, R99673
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for WAPAL
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | · | |
| SP1: | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for WAPAL
5 Ensembl transcripts including schematic representations: ENST00000342368
ENST00000372076
ENST00000372075
ENST00000298767
ENST00000263070
|
Expression for WAPAL
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| WAPAL expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for WAPAL
1 / 2 / 3 6 probe-sets matching WAPAL gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene clusters: Hs.203099 Hs.714876 UniProtKB/Swiss-Prot: WAPL_HUMAN, Q7Z5K2Tissue specificity: Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely espressed with a high level in skeletal muscle and heart |
Orthologs for WAPAL
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for WAPAL gene from 5/8 species (see all 8
)
About this table Species with no ortholog for WAPAL
ENSEMBL Gene Tree for WAPAL | Paralogs for WAPAL(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for WAPAL(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for WAPAL (up to first 250kb)
|
Disorders & Mutations for WAPAL
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 610754
|
Medical News for WAPAL(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for WAPAL (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/17 PubMed articles for WAPAL gene (see all 17
):- Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)2, 3, 4 Nagase T....Nomura N. (1996)
- Identification and cloning of a novel chromatin-associated protein partner of Epstein-Barr nuclear protein 2. (PubMed id 15383329)1, 3, 4 Kwiatkowski B.A.... Schubach W.H. (2004)
- Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. (PubMed id 17112726)2, 3 Gandhi R....Hirano T. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression. (PubMed id 15150110)3, 4 Oikawa K.... Mukai K. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)3, 4 Deloukas P.... Rogers J. (2004)
- Expression of various types of alternatively spliced WAPL transcripts in human cervical epithelia. (PubMed id 18662753)1, 3 Oikawa K.... Kuroda M. (2008)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)4 Daub H.... Mann M. (2008)
- Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866)4 Imami K.... Ishihama Y. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
|
Search for WAPAL
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing WAPAL
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing WAPAL
(According to HUGE)
About This Section
| |
Specialized Databases showing WAPAL(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for WAPAL(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for WAPAL:

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| | Recombinant Proteins (WAPL) | | Antibodies (WAPL) |
| | | Search Tocris compounds for WAPAL |
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Incremental update: 13 Oct 2009
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